Claims
- 1. A quaternary ammonium compound of formula I
- 2. The compound of claim 1, wherein X is selected from the group consisting of the anions of the following acids: tartaric, hydrochloric, hydrobromic, hydroiodic, sulfuric, phosphoric, nitric, citric, methanesulfonic, CH3—(CH2)n—COOH where n is 0-4, HOOC—(CH2)n—COOH where n is 1-4, HOOC—CH═CH—COOH, and benzoic.
- 3. The compound of claim 1, wherein X is selected from the group consisting of iodide, bromide, and chloride.
- 4. The compound of claim 1, wherein X is iodide.
- 5. The compound of claim 1, wherein X is bromide.
- 6. The compound of claim 1, wherein X is chloride.
- 7. The compound of claim 1, wherein R1 is methyl.
- 8. A compound (3S)-3-(2-amino-2-oxo-1,1-diphenylethyl)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]-1-methylpyrrolidinium iodide.
- 9. A pharmaceutical composition comprising a therapeutically effective amount of a quaternary ammonium compound of formula I
- 10. The pharmaceutical composition of claim 9, wherein the pharmaceutical composition further comprises a suitable pharmaceutical carrier.
- 11. A method of treating asthma in a mammal, comprising administering a therapeutically effective amount of a quaternary ammonium compound of formula I to a mammal in need of such a treatment, wherein the compound of formula I has the structure
- 12. A method of treating chronic obstructive pulmonary disease in a mammal, comprising administering a therapeutically effective amount of a quaternary ammonium compound of formula I to a mammal in need of such a treatment, wherein the compound of formula I has the structure
- 13. A method of treating allergic rhinitis in a mammal, comprising administering a therapeutically effective amount of a quaternary ammonium compound of formula I to a mammal in need of such a treatment, wherein the compound of formula I has the structure
- 14. A method of treating infectious rhinitis in a mammal, comprising administering a therapeutically effective amount of a quaternary ammonium compound of formula I to a mammal in need of such a treatment, wherein the compound of formula I has the structure
CROSS-REFERENCE
[0001] This application claims the benefit of U.S. Provisional Application Serial No. 60/421,417 filed on Oct. 25, 2002, under 35 USC 119(e)(i).
Provisional Applications (1)
|
Number |
Date |
Country |
|
60421417 |
Oct 2002 |
US |