Claims
- 1. A method for preventing or relieving nausea and emesis associated with the use or narcotic analgesics in warm-blooded animals, which comprises administering to an animal prone towards nausea or emesis on receiving narcotic analgesics, an amount of at least about 0.05 mg/kg and less than 0.25 mg/kg of at least one nausea and emesis relieving compound of the formula: ##STR3## wherein R is allyl or a related radical such as chloroallyl, cyclopropyl-methyl or propargyl, and
- X is the anion of an acid, especially a chloride, bromide, iodide or methylsulfate anion, prior to or simultaneously with administration of the narcotic analgesic.
- 2. A method as claimed in claim 1, wherein the compound is administered to the animal enterally.
- 3. A method as claimed in claim 1, where the compound is administered to the animal parenterally.
- 4. A method as claimed in claim 3, where the compound is administered to the animal by injection.
- 5. A method as claimed in claim 1, where the compound is administered to the animal prior to the administration of the narcotic analgesic.
- 6. A method as claimed in claim 5, where the compound is administered to the animal up to about two hours prior to the administration of the narcotic analgesic.
- 7. A method as claimed in claim 1, where the compound si administered to the animal concurrently with the administration of the narcotic analgesic.
- 8. A method as claimed in claim 1, where the compound comprises methylnaltrexone.
- 9. A method for preventing or relieving nausea and emesis associated with the use of narcotic analgesics in warm-blooded animals, which comprises administering to an animal prone to exhibit nausea or emesis on administration of narcotic analgesics, methylnaltrexone in the amount of at least about 0.05 mg/kg and less than about 0.25 mg/kg simultaneous with or up to about two hours prior to the time of administration of the narcotic analgesic.
- 10. A method as claimed in claim 9, where the methylnaltrexone is administered to the animal parenterally.
Parent Case Info
This is a continuation-in-part of application Ser. No. 837,399 filed Mar. 7, 1986 now U.S. Pat. No 4,719,215.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4719215 |
Goldberg |
Jan 1988 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
837399 |
Mar 1986 |
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