Claims
- 1. A compound of formula I:
- 2. A compound according to claim 1, wherein:
ring M is selected from phenyl, pyrrole, furan, thiophene, pyrazole, imidazole, isoxazole, oxazole, isothiazole, thiazole, 1,2,3-triazole, 1,2,3-oxadiazole, 1,2,3-thiadiazole, pyridine, pyrimidine, pyridazine, pyrazine, 1,2,3-triazine, 1,2,4-triazine, and 1,2,3,4-tetrazine; ring M is substituted with 0-3 R1a—; one of P4 and M4 is -Z-A-B and the other -G1-G; G is a group of formula IIa or IIb: 35ring D, including the two atoms of Ring E to which it is attached, is a 5-6 membered ring consisting of: carbon atoms and 0-2 heteroatoms selected from the group consisting of N, O, and S(O)p; ring D is substituted with 0-2 R and has 0-3 ring double bonds; E is selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, and pyridazinyl, and is substituted with 1-2 R; alternatively, ring D is absent, and ring E is selected from phenyl, pyridyl, pyrimidyl, and thienyl, and ring E is substituted with 1-2 R; alternatively, ring D is absent, ring E is selected from phenyl, pyridyl, and thienyl, and ring E is substituted with a 5 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, wherein the heterocycle is substituted with 0-1 carbonyls, 1-2 R, and 0-3 ring double bonds; R is selected from H, C1-4 alkyl, F, Cl, OH, OCH3, —OCH2CH3, —OCH(CH3)2, CN, —C(═NH)NH2, NH2, —NH(C1-3 alkyl)2, —N(C1-3 alkyl)2, —C(═NH)NH2, —CH2NH2, —CH2NH(C1-3 alkyl), —CH2N(C1-3 alkyl)2, —(CR8R9)tNR7R8, —C(O)NR7R8, —CH2C(O)NR7R8, —S(O)pNR7R8, —CH2S(O)pNR7R8, and —OCF3; alternatively, when 2 R groups are attached to adjacent atoms, they combine to form methylenedioxy or ethylenedioxy; A is selected from one of the following rings and is substituted with 0-2 R4; phenyl, piperidinyl, piperazinyl, pyridyl, pyrimidyl, furanyl, morpholinyl, thiophenyl, pyrrolyl, pyrrolidinyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, triazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,5-thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,5-triazolyl, 1,3,4-triazolyl, benzofuranyl, benzothiofuranyl, indolyl, benzimidazolyl, benzoxazolyl, benzthiazolyl, indazolyl, benzisoxazolyl, benzisothiazolyl, and isoindazolyl; B is selected from Y, X—Y, —CH2NR2R2a, and —CH2CH2NR2R2a; X is selected from —(CR2R2a)1-4—, —C(O)—, —C(═NR1b)—, —CR2(NR1bR2)—, —C(O)CR2R2a—, —CR2R2aC(O), —C(O)NR2—, —NR2C(O)—, —C(O)NR2CR2R2a—, —NR2C(O)CR2R2a—, —CR2R2aC(O)NR2—, —CR2R2aNR2C(O)—, —NR2C(O)NR2—, —NR2—, —NR2CR2R2a, CR2R2aNR2, —O—, —CR2R2aO—, and —OCR2R2a—; Y is selected from one of the following rings and is substituted with 0-2 R4a; cyclopropyl, cyclopentyl, cyclohexyl, phenyl, piperidinyl, piperazinyl, pyridyl, pyrimidyl, furanyl, morpholinyl, thiophenyl, pyrrolyl, pyrrolidinyl, oxazolyl, isoxazolyl, isoxazolinyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,5-thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,5-triazolyl, 1,3,4-triazolyl, benzofuranyl, benzothiofuranyl, indolyl, benzimidazolyl, benzoxazolyl, benzthiazolyl, indazolyl, benzisoxazolyl, benzisothiazolyl, and isoindazolyl; alternatively, Y is selected from the following bicyclic heteroaryl ring systems: 36K is selected from O, S, NH, and N; G1 is absent or is selected from —(CR3R3a)1-3—, —(CR3R3a)uC(O)(CR3R3a)w—, —(CR3R3a)uO(CR3R3a)w—, —(CR3R3a)uNR3b(CR3R3a)w, —(CR3R3a)uC(O)NR3b(CR3R3a)w—, —(CR3R3a)uNR3bC(O)(CR3R3a)w—, —(CR3R3a)uNR3bC(O)(CR3R3a)uC(O)NR3b(CR3R3a)w—, —(CR3R3a)uS(CR3R3a)w—, —(CR3R3a)uS(O)(CR3R3a)w—, —(CR3R3a)uS(O)2(CR3R3a)w—, —(CR3R3a)uS(O)NR3b(CR3R3a)w—, —(CR3R3a)uNR3bS(O)2(CR3R3a)w—, and —(CR3R3a)uS(O)2NR3b(CR3R3a)w—, wherein u+w total 0, 1, or 2, provided that G1 does not form a N—S, NCH2N, NCH2O, or NCH2S bond with either group to which it is attached; Z is selected from a bond, CH2, CH2CH2, CH2O, OCH2, C(O), NH, CH2NH, NHCH2, CH2C(O), C(O)CH2, C(O)NH, NHC(O), NHC(O)CH2C(O)NH, S(O)2, CH2S(O)2, S(O)2(CH2), SO2NH, and NHSO2, provided that Z does not form a N—S, NCH2N, NCH2O, or NCH2S bond with either group to which it is attached; R1a, at each occurrence, is selected from H, —(CH2)r—R1b, —(CH(CH3))r—R1b, —(C(CH3)2)r—R1b, —O—(CR3R3a)r—R1b, —NR2—(CR3R3a)r—R1b, and —S—(CR3R3a)r—R1b, provided that R1a forms other than an N-halo, N—S, O—O, or N—CN bond; alternatively, when two R1a groups are attached to adjacent atoms, together with the atoms to which they are attached they form a 5-7 membered ring consisting of: carbon atoms and 0-2 heteroatoms selected from the group consisting of N, O, and S(O)p, this ring being substituted with 0-2 R4b and 0-3 ring double bonds; R1b is selected from H, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, F, Cl, Br, I, CN, CHO, CF3, OR2, —NR2R2a, —C(O)R2b, —CO2R2b, —OC(O)R2, —CO2R2a, —S(O)pR2b, —NR2(CH2)rOR2, —NR2C(O)R2b, —NR2C(O)NHR2, —NR2C(O)2R2a, —OC(O)NR2R2a, —C(O)NR2R2a, —C(O)NR2(CH2)rOR2, —SO2NR2R2a, —NR2SO2R2, C5-6 carbocycle substituted with 0-2 R4b, and 5-6 membered heterocycle substituted with 0-2 R4b and consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, provided that R1b forms other than an O—O, N-halo, N—S, or N—CN bond and provided that S(O)pR2 forms other than S(O)2H or S(O)H; R2, at each occurrence, is selected from H, CF3, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, CH2CH2CH2CH3, CH2CH(CH3)2, CH(CH3)CH2CH3, C(CH3)3, benzyl, C3-6 carbocycle substituted with 0-2 R4b, C3-6 carbocycle-CH2—substituted with 0-2 R4b, and 5-6 membered heterocycle substituted with 0-2 R4b and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; R2a, at each occurrence, is selected from H, CF3, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, CH2CH2CH2CH3, CH2CH(CH3)2, CH(CH3)CH2CH3, C(CH3)3, benzyl, C5-6 carbocycle substituted with 0-2 R4b, and 5-6 membered heterocycle substituted with 0-2 R4b and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; alternatively, R2 and R2a, together with the nitrogen atom to which they are attached, combine to form a 5 or 6 membered saturated, partially saturated, or unsaturated ring substituted with 0-2 R4b and consisting of: 0-1 additional heteroatoms selected from the group consisting of N, O, and S(O)p; R2b, at each occurrence, is selected from CF3, C1-4 alkoxy, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, CH2CH2CH2CH3, CH2CH(CH3)2, CH(CH3)CH2CH3, C(CH3)3, benzyl, C5-6 carbocycle substituted with 0-2 R4b, and 5-6 membered heterocycle substituted with 0-2 R4b and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; R2c, at each occurrence, is selected from CF3, OH, C1-4 alkoxy, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, CH2CH2CH2CH3, CH2CH(CH3)2, CH(CH3)CH2CH3, C(CH3)3, benzyl, C5-6 carbocycle substituted with 0-2 R4b, and 5-6 membered heterocycle substituted with 0-2 R4b and consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; R3, at each occurrence, is selected from H, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, benzyl, and phenyl; R3a, at each occurrence, is selected from H, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, benzyl, and phenyl; R3c, at each occurrence, is selected from CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, benzyl, and phenyl; R3d, at each occurrence, is selected from H, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, CH2-phenyl, CH2CH2-phenyl, and C(═O)R3c; R4, at each occurrence, is selected from H, ═O, OR2, —CH2OR2, —(CH2)2OR2, F, Cl, Br, I, C1-4 alkyl, CN, NO2, —NR2R2a, —CH2NR2R2a, —(CH2)2NR2R2a, —C(O)R2c, —NR2C(O)R2b, —C(O)NR2R2a, —SO2NR2R2a, —S(O)pR5a, CF3, CF2CF3, 5-6 membered carbocycle substituted with 0-1 R5, and a 5-6 membered heterocycle substituted with 0-1 R5 and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; R4a, at each occurrence, is selected from H, ═O, —(CR3R3a)rOR2, —(CR3R3a)r—F, —(CR3R3a)r—Br, —(CR3R3a)r—Cl, C1-4 alkyl, —(CR3R3a)r—CN, —(CR3R3a)rNO2, —(CR3R3a)rNR2R2a, (CR3R3a)rC(O)R2c, (CR3R3a)rNR2C(O)R2b, —(CR3R3a)rC(O)NR2R2a, (CR3R3a)rSO2NR2R2a, (CR3R3a)rNR2SO2NR2R2a, —(CR3R3a)rNR2SO2—C1-4 alkyl, (CR3R3a)rC(O)NHSO2—C1-4 alkyl, —CR3R3a)rNR2SO2R5, —(CR3R3a)rS(O)pR5, —(CR3R3a)r(CF2)rCF3, phenyl substituted with 0-1 R5, and a 5 membered aromatic heterocycle consisting of: carbon atoms and 1-3 heteroatoms selected from the group consisting of N, O, and S(O)p substituted with 0-1 R5; R4b, at each occurrence, is selected from H, ═O, OR3, CH2OR3, F, Cl, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, CH2CH2CH2CH3, CH2CH(CH3)2, CH(CH3)CH2CH3, C(CH3)3, CN, NO2, —NR3R3a, —CH2NR3R3a, —C(O)R3, —CH2—C(O)R3, —C(O)OR3c, —CH2C(O)OR3c, —NR3C(O)R3a, —CH2NR3C(O)R3a, —C(O)NR3R3a, —CH2C(O)NR3R3a, —NR3C(O)NR3R3a, —CH2NR3C(O)NR3R3a, —C(═NR3)NR3R3a, —CH2C(═NR3)NR3R3a, —NR3C(═NR3)NR3R3a, —CH2NR3C(═NR3)NR3R3a, —SO2NR3R3a, —CH2SO2NR3R3a, —NR3SO2NR3R3a, —CH2NR3SO2NR3R3a, —NR3SO2—C1-4 alkyl, —CH2NR3SO2—C1-4 alkyl, —NR3SO2CF3, —CH2NR3SO2CF3, —NR3SO2-phenyl, —CH2NR3SO2-phenyl, —S(O)pCF3, —CH2S(O)pCF3, —S(O)p—C1-4 alkyl, —CH2S(O)p—C1-4 alkyl, —S(O)p-phenyl, —CH2S(O)p-phenyl, CF3, and CH2—CF3; R5, at each occurrence, is selected from H, ═O, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, CH2CH2CH2CH3, CH2CH(CH3)2, CH(CH3)CH2CH3, C(CH3)3, OR3, —CH2OR3, F, Cl, CN, NO2, —NR3R3a, —CH2NR3R3a, —C(O)R3, —CH2C(O)R3, —C(O)OR3c, —CH2C(O)OR3c, —NR3C(O)R3a, —C(O)NR3R3a, —NR3C(O)NR3R3a, —CH(═NOR3d), —C(═NR3)NR3R3a, —NR3C(═NR3)NR3R3a, —SO2NR3R3a, —NR3SO2NR3R3a, —NR3SO2—C1-4 alkyl, —NR3SO2CF3, —NR3SO2-phenyl, —S(O)pCF3, —S(O)p—C1-4 alkyl, —S(O)p-phenyl, CF3, phenyl substituted with 0-2 R6, naphthyl substituted with 0-2 R6, and benzyl substituted with 0-2 R6; R6, at each occurrence, is selected from H, OH, OR2, F, Cl, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, CH2CH2CH2CH3, CH2CH(CH3)2, CH(CH3)CH2CH3, C(CH3)3, CN, NO2, —NR2R2a, —CH2NR2R2a, —C(O)R2b, —CH2C(O)R2b, —NR2C(O)R2b, —NR2C(O)NR2R2a, —C(═NH)NH2, —NHC(═NH)NH2, —SO2NR2R2a, —NR2SO2NR2R2a, and —NR2SO2C1-4 alkyl; and r, at each occurrence, is selected from 0, 1, 2, and 3.
- 3. A compound according to claim 2, wherein:
ring M is selected from phenyl, pyrrole, furan, thiophene, pyrazole, imidazole, isoxazole, oxazole, isothiazole, thiazole, pyridine, and pyrimidine; ring M is substituted with 0-2 R1a; G is selected from the group: 3738394041424344R1a, at each occurrence, is selected from H, R1b, —CH(CH3)R1b, —C(CH3)2R1b, —2R1b, and —CH2CH2R1b, provided that R1a forms other than an N-halo, N—S, or N—CN bond; alternatively, when two R1a groups are attached to adjacent atoms, together with the atoms to which they are attached, they form a 5-6 membered ring consisting of: carbon atoms and 0-2 heteroatoms selected from the group consisting of N, O, and S(O)p, this ring being substituted with 0-2 R4b and 0-3 ring double bonds; R1b is selected from H, CH3, CH2CH3, F, Cl, Br, CN, CHO, CF3, OR2, —NR2R2a, —C(O)R2b, —CO2R2b, —OC(O)R2, —CO2R2a, —S(O)pR2, —NR2(CH2)rOR2, —NR2C(O)R2b, —C(O)NR2R2a, —SO2NR2R2a, —NR2SO2R2, phenyl substituted with 0-2 R4b, and 5-6 membered aromatic heterocycle consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p and substituted with 0-2 R4b, provided that R1b forms other than an O—O, N-halo, N—S, or N—CN bond; R2, at each occurrence, is selected from H, CF3, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, phenyl substituted with 0-2 R4b, a benzyl substituted with 0-2 R4b, C3-6 cycloalkyl substituted with 0-2 R4b, C3-6 cycloalkyl-CH2— substituted with 0-2 R4b, and 5-6 membered aromatic heterocycle substituted with 0-2 R4b and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; R2a, at each occurrence, is selected from H, CF3, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, benzyl, phenyl substituted with 0-2 R4b, and 5-6 membered aromatic heterocycle substituted with 0-2 R4b and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; R2b, at each occurrence, is selected from CF3, C1-4 alkoxy, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, benzyl, phenyl substituted with 0-2 R4b, and 5-6 membered aromatic heterocycle substituted with 0-2 R4b and consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; R2c, at each occurrence, is selected from CF3, OH, OCH3, OCH2CH3, OCH2CH2CH3, OCH(CH3)2, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, benzyl, phenyl substituted with 0-2 R4b, and 5-6 membered aromatic heterocycle substituted with 0-2 R4b and consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p; alternatively, R2 and R2a, together with the nitrogen atom to which they are attached, combine to form a 5 or 6 membered saturated, partially saturated, or unsaturated ring substituted with 0-2 R4b and consisting of: 0-1 additional heteroatoms selected from the group consisting of N, O, and S(O)p; R4, at each occurrence, is selected from H, —(CH2)2OR2, —CH2OR2, OR2, F, Cl, Br, I, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, CH2CH2CH2CH3, CH2CH(CH3)2, CH(CH3)CH2CH3, C(CH3)3, CN, NO2, —NR2R2a, —CH2NR2R2a, —(CH2)2NR2R2a, —C(O)R2c, —NR2C(O)R2b, —C(O)NR2R2a, —SO2NR2R2a, CF3, and CF2CF3; R4a, at each occurrence, is selected from H, ═O, —(CH2)rOR2, —(CH2)r—F, —(CH2)r—Br, —(CH2)r—Cl, C1-4 alkyl, —(CH2)r—CN, —(CH2)rNO2, —(CH2)rNR2R2a, —(CH2)rC(O)R2c, —(CH2)rNR2C(O)R2b, —(CH2)rC(O)NR2R2a, —(CH2)rSO2NR2R2a, —(CH2)rNR2SO2NR2R2a, (CH2)rNR2SO2—C1-4 alkyl, —(CH2)rC(O)NHSO2—C1-4 alkyl, —(CH2)rNR2SO2R5, (CH2)rS(O)pR5, —(CH2)r(CF2)rCF3, phenyl substituted with 0-1 R5, and a 5 membered aromatic heterocycle consisting of: carbon atoms and 1-3 heteroatoms selected from the group consisting of N, O, and S(O)p substituted with 0-1 R5; R4b, at each occurrence, is selected from H, ═O, OR3, —CH2OR3, F, Cl, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, CN, NO2, —NR3R3a, —CH2NR3R3a, —C(O)R3, —CH2—C(O)R3, —C(O)OR3c, —CH2—C(O)OR3c, —NR3C(O)R3a, —CH2NR3C(O)R3a, —C(O)NR3R3a, —CH2—C(O)NR3R3a, —SO2NR3R3a, —CH2SO2NR3R3a, —NR3SO2—C1-4 alkyl, —CH2NR3SO2—C1-4 alkyl, —NR3SO2-phenyl, —CH2NR3SO2-phenyl, —S(O)pCF3, —CH2S(O)pCF3, —S(O)p—C1-4 alkyl, —CH2S(O)p—C1-4 alkyl, —S(O)p-phenyl, —CH2S(O)p-phenyl, and CF3; R5, at each occurrence, is selected from H, ═O, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, OR3, CH2OR3, F, Cl, CN, NO2, —NR3R3a, —CH2NR3R3a, —C(O)R3, —CH2C(O)R3, —C(O)OR3c, —CH2C(O)OR3c, —NR3C(O)R3a, —C(O)NR3R3a, —SO2NR3R3a, —NR3SO2—C1-4 alkyl, —NR3SO2CF3, —NR3SO2-phenyl, —S(O)pCF3, —S(O)p—C1-4 alkyl, —S(O)p-phenyl, CF3, phenyl substituted with 0-2 R6, naphthyl substituted with 0-2 R6, and benzyl substituted with 0-2 R6; R6, at each occurrence, is selected from H, OH, OR2, F, Cl, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, CN, NO2, —NR2R2a, —CH2NR2R2a, —C(O)R2b, —CH2C(O)R2b, —NR2C(O)R2b, —SO2NR2R2a, and NR2SO2C1-4 alkyl; and r, at each occurrence, is selected from 0, 1, and 2.
- 4. A compound according to claim 3, wherein the compound is selected from:
- 5. A compound according to claim 4, wherein the compound is selected from:
- 6. A compound according to claim 5, wherein the compound is selected from:
- 7. A compound according to claim 6, wherein the compound is selected from the group:
2-biphenyl-4-yl-6-chloro-3-(4-chloro-phenyl)-3H-quinazolin-4-one; 6-chloro-3-(4-chloro-phenyl)-2-phenyl-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1H-pyrrol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-methyl-1H-pyrrol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-ethyl-1H-pyrrol-2-yl)-phenyl]-3H-quinazolin-4-one; 2-{4-[1-(2-amino-ethyl)-1H-pyrrol-2-yl]-phenyl}-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-{4-[1-(2-methylamino-ethyl)-1H-pyrrol-2-yl]-phenyl}-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-{4-[1-(2-ethylamino-ethyl)-1H-pyrrol-2-yl]-phenyl}-3H-quinazolin-4-one; 2-{4-[1-(2-benzylamino-ethyl)-1H-pyrrol-2-yl]-phenyl}-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; 3-pyridin-2-yl-2-[4-(1-{2-[(pyridin-2-ylmethyl)-amino]-ethyl}-1H-pyrrol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-pyridin-2-yl-2-[4-(1-{2-[(pyridin-3-ylmethyl)-amino]-ethyl}-1H-pyrrol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-pyridin-2-yl-2-[4-(1-{2-[(pyridin-4-ylmethyl)-amino]-ethyl}-1H-pyrrol-2-yl)-phenyl]-3H-quinazolin-4-one; 2-[4-(1-benzyl-1H-pyrrol-2-yl)-phenyl]-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-pyridin-2-ylmethyl-1H-pyrrol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-pyridin-3-ylmethyl-1H-pyrrol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-pyridin-4-ylmethyl-1H-pyrrol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-cyclohexyl-1H-pyrrol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-{4-[1-(tetrahydro-pyran-4-yl)-1H-pyrrol-2-yl]-phenyl}-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-piperidin-4-yl-1H-pyrrol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-{4-[1-(1-methyl-piperidin-4-yl)-1H-pyrrol-2-yl]-phenyl}-3H-quinazolin-4-one; 2-{4-[1-(1-acetyl-piperidin-4-yl)-1H-pyrrol-2-yl]-phenyl}-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-isopropyl-1H-pyrrol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-cyclopropyl-1H-pyrrol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-cyclobutyl-1H-pyrrol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-cyclopentyl-1H-pyrrol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-{4-[1-(tetrahydro-furan-3-yl)-1H-pyrrol-2-yl]-phenyl}-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(2′,3′,4′,5′-tetrahydro-1′H-[1,3′]bipyrrolyl-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1′-methyl-2′,3′,4′,5′-tetrahydro-1′H-[1,3′]bipyrrolyl-2-yl)-phenyl]-3H-quinazolin-4-one; 2-[4-(1′-acetyl-2′,3′,4′,5′-tetrahydro-1′H-[1,3′]bipyrrolyl-2-yl)-phenyl]-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1 ′-methanesulfonyl-2′,3′,4′,5′-tetrahydro-1′H-[1,3′]bipyrrolyl-2-yl)-phenyl]-3H-quinazolin-4-one; N-[2-(2-{4-[3-(5-chloro-pyridin-2-yl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-phenyl}-pyrrol-1-yl)-ethyl]-acetamide; 3-(5-chloro-pyridin-2-yl)-2-{4-[1-(2-hydroxy-ethyl)-1H-pyrrol-2-yl]-phenyl}-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-{4-[1-(2-methoxy-ethyl)-1H-pyrrol-2-yl]-phenyl}-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-{4-[1-(2-methoxy-1-methyl-ethyl)-1H-pyrrol-2-yl]-phenyl}-3H-quinazolin-4-one; 2-(2-{4-[3-(5-chloro-pyridin-2-yl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-phenyl}-pyrrol-1-yl)-acetamide; 2-(2-{4-[3-(5-chloro-pyridin-2-yl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-phenyl}-pyrrol-1-yl)-N-methyl-acetamide; 3-(5-chloro-pyridin-2-yl)-2-[4-(1H-imidazol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-methyl-1H-imidazol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-ethyl-1H-imidazol-2-yl)-phenyl]-3H-quinazolin-4-one; 2-{4-[1-(2-amino-ethyl)-1H-imidazol-2-yl]-phenyl}-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; 3-{5-chloro-pyridin-2-yl)-2-(4-[1-(2-methylamino-ethyl)-1H-imidazol-2-yl]-phenyl}-3H-quinazolin-4-one; 2-{4-[1-(2-ethylamino-ethyl)-1H-imidazol-2-yl]-phenyl}-3-pyridin-2-yl-3H-quinazolin-4-one; 2-{4-[1-(2-benzylamino-ethyl)-1H-imidazol-2-yl]-phenyl}-3-pyridin-2-yl-3H-quinazolin-4-one; 3-pyridin-2-yl-2-[4-(1-{2-[(pyridin-2-ylmethyl)-amino]-ethyl}-1H-imidazol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-pyridin-2-yl-2-[4-(1-{2-[(pyridin-3-ylmethyl)-amino]-ethyl}-1H-imidazol-2-yl)-phenyl]-3H-quinazolin-4-one; 2-{4-[1-(2-benzylamino-ethyl)-1H-imidazol-2-yl]-phenyl}-3-pyridin-2-yl-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-pyridin-2-ylmethyl-1H-imidazol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-pyridin-3-ylmethyl-1H-imidazol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-pyridin-4-ylmethyl-1H-imidazol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-cyclohexyl-1H-imidazol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-{4-[1-(tetrahydro-pyran-4-yl)-1H-imidazol-2-yl]-phenyl}-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-piperidin-4-yl-1H-imidazol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-{4-[1-(1-methyl-piperidin-4-yl)-1H-imidazol-2-yl]-phenyl}-3H-quinazolin-4-one; 2-{4-[1-(1-acetyl-piperidin-4-yl)-1H-imidazol-2-yl]-phenyl}-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-isopropyl-1H-imidazol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-cyclopropyl-1H-imidazol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-cyclobutyl-1H-imidazol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-cyclopentyl-1H-imidazol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-{4-[1-(tetrahydro-furan-3-yl)-1H-imidazol-2-yl]-phenyl}-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-pyrrolidin-3-yl-1H-imidazol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-{4-[1-(1-methyl-pyrrolidin-3-yl)-1H-imidazol-2-yl]-phenyl}-3H-quinazolin-4-one; 2-{4-[1-(1-acetyl-pyrrolidin-3-yl)-1H-imidazol-2-yl]-phenyl}-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-{4-[1-(1-methanesulfonyl-pyrrolidin-3-yl)-1H-imidazol-2-yl]-phenyl}-3H-quinazolin-4-one; N-[2-(2-{4-[3-(5-chloro-pyridin-2-yl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-phenyl}-imidazol-1-yl)-ethyl]-acetamide; 3-(5-chloro-pyridin-2-yl)-2-{4-[1-(2-hydroxy-ethyl)-1H-imidazol-2-yl]-phenyl}-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-{4-[1-(2-methoxy-ethyl)-1H-imidazol-2-yl]-phenyl}-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-{4-[1-(2-methoxy-1-methyl-ethyl)-1H-imidazol-2-yl]-phenyl}-3H-quinazolin-4-one; 2-(2-{4-[3-(5-chloro-pyridin-2-yl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-phenyl}-imidazol-1-yl)-acetamide; 2-(2-{4-[3-(5-chloro-pyridin-2-yl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-phenyl}-imidazol-1-yl)-N-methyl-acetamide; 2-[4-(5-amino-furan-2-yl)-phenyl]-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; 2-[4-(5-aminomethyl-furan-2-yl)-phenyl]-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; 5-{4-[3-(5-chloro-pyridin-2-yl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-phenyl}-furan-2-carboxylic acid amide; 2-{4-[5-(1-amino-1-methyl-ethyl)-furan-2-yl]-phenyl}-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; 2-[4-(3-amino-furan-2-yl)-phenyl]-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(3-dimethylaminomethyl-furan-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-{4-[3-(1-dimethylamino-1-methyl-ethyl)-furan-2-yl]-phenyl}-3H-quinazolin-4-one; 2-{4-[3-(5-chloro-pyridin-2-yl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-phenyl}-furan-3-carboxylic acid amide; 3-(5-chloro-pyridin-2-yl)-2-(4-oxazol-2-yl-phenyl)-3H-quinazolin-4-one; 2-[4-(5-aminomethyl-oxazol-2-yl)-phenyl]-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; 2-{4-[3-(5-chloro-pyridin-2-yl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-phenyl}-oxazole-5-carboxylic acid amide; 2-[4-(4-aminomethyl-oxazol-2-yl)-phenyl]-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; 2-{4-[3-(5-chloro-pyridin-2-yl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-phenyl}-oxazole-4-carboxylic acid amide; 3-(5-chloro-pyridin-2-yl)-2-(4-thiazol-2-yl-phenyl)-3H-quinazolin-4-one; 2-[4-(5-aminomethyl-thiazol-2-yl)-phenyl]-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; 2-{4-[3-(5-chloro-pyridin-2-yl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-phenyl}-thiazole-5-carboxylic acid amide; 2-[4-(4-amino-thiazol-2-yl)-phenyl]-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; N-(2-{4-[3-(5-chloro-pyridin-2-yl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-phenyl}-thiazol-4-yl)-acetamide; 2-[4-(5-amino-thiazol-2-yl)-phenyl]-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; N-(2-{4-[3-(5-chloro-pyridin-2-yl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-phenyl}-thiazol-5-yl)-acetamide; 3-(5-chloro-pyridin-2-yl)-2-[4-(2-oxo-tetrahydro-pyrimidin-1-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(2-oxo-imidazolidin-1-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(2-oxo-[1,3]diazepan-1-yl)-phenyl]-3H-quinazolin-4-one; 2-[4-(3-amino-2-oxo-piperidin-1-yl)-phenyl]-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(3-dimethylamino-2-oxo-piperidin-1-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(2-oxo-3-pyrrolidin-1-yl-piperidin-1-yl)-phenyl]-3H-quinazolin-4-one; N-(1-{4-[3-(5-chloro-pyridin-2-yl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-phenyl}-2-oxo-piperidin-3-yl)-acetamide; 2-[4-(3-amino-2-oxo-pyrrolidin-1-yl)-phenyl]-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(2-dimethylaminomethyl-imidazol-1-yl)-phenyl]-3H-quinazolin-4-one; 1-{4-[3-(5-chloro-pyridin-2-yl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-phenyl}-1H-imidazole-2-carboxylic acid dimethylamide; 3-(5-chloro-pyridin-2-yl)-2-(4-isoxazol-5-yl-phenyl)-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-(4-oxazol-5-yl-phenyl)-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-(4-thiazol-5-yl-phenyl)-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(3H-[1,2,3]triazol-4-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(5-methyl-4H-[1,2,4]triazol-3-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(5-methyl-[1,3,4]thiadiazol-2-yl)-phenyl]-3H-quinazolin-4-one; 2-biphenyl-4-yl-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; 2-(2′-amino-biphenyl-4-yl)-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-(2′-dimethylamino-biphenyl-4-yl)-3H-quinazolin-4-one; 2-(2′-aminomethyl-biphenyl-4-yl)-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-(2′-dimethylaminomethyl-biphenyl-4-yl)-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-(4-pyridin-2-yl-phenyl)-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-(4-pyridin-3-yl-phenyl)-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-(4-pyridin-4-yl-phenyl)-3H-quinazolin-4-one; 2-[4-(2-amino-pyridin-3-yl)-phenyl]-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; 2-[4-(2-aminomethyl-pyridin-3-yl)-phenyl]-3-(5-chloro-pyridin-2-yl)-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(2-dimethylaminomethyl-pyridin-3-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[2-fluoro-4-(2-oxo-piperidin-1-yl)-phenyl]-3H-quinazolin-4-one; 6-chloro-3-(5-chloro-pyridin-2-yl)-2-[2-fluoro-4-(2-oxo-piperidin-1-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-6-fluoro-2-[2-fluoro-4-(2-oxo-piperidin-1-yl)-phenyl]-3H-quinazolin-4-one; 6-bromo-3-(5-chloro-pyridin-2-yl)-2-[2-fluoro-4-(2-oxo-piperidin-1-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[2-fluoro-4-(2-oxo-piperidin-1-yl)-phenyl]-4-oxo-3,4-dihydro-quinazoline-6-carbonitrile; 3-(5-chloro-pyridin-2-yl)-2-[2-fluoro-4-(2-oxo-piperidin-1-yl)-phenyl]-6-methoxy-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[2-fluoro-4-(2-oxo-piperidin-1-yl)-phenyl]-4-oxo-3,4-dihydro-quinazoline-6-carboxylic acid amide; 6-chloro-3-(5-chloro-pyridin-2-yl)-2-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-6-methoxy-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-6-fluoro-2-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-4-oxo-3,4-dihydro-quinazoline-6-carbonitrile; 3-(4-chloro-phenyl)-2-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-3H-quinazolin-4-one; 2-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-3-(4-methoxy-phenyl)-3H-quinazolin-4-one; 3-(3-chloro-phenyl)-2-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-3H-quinazolin-4-one; 2-fluoro-5-{2-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-4-oxo-4H-quinazolin-3-yl}-benzonitrile; 3-(5-chloro-pyridin-2-yl)-2-[4-(2-oxo-pyrrolidin-1-yl)-phenyl]-3H-quinazolin-4-one; 3-(4-chloro-phenyl)-2-[4-(1H-pyrrol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(4-methoxy-phenyl)-2-[4-(1H-pyrrol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(3-chloro-phenyl)-2-[4-(1H-pyrrol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(3-chloro-phenyl)-2-[4-(1-methyl-1H-pyrrol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(4-chloro-phenyl)-2-[4-(1-methyl-1H-pyrrol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-6-methoxy-2-[4-(1-methyl-1H-pyrrol-2-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-{4-[1-(2-dimethylamino-ethyl)-1H-pyrrol-2-yl]-phenyl}-6-methoxy-3H-quinazolin-4-one; 6-chloro-3-(5-chloro-pyridin-2-yl)-2-{4-[1-(2-dimethylamino-ethyl)-1H-pyrrol-2-yl]-phenyl}-3H-quinazolin-4-one; 6-chloro-3-(4-chloro-phenyl)-2-{4-[1-(2-dimethylamino-ethyl)-1H-pyrrol-2-yl]-phenyl}-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-6-methoxy-2-[4-(2-oxo-imidazolidin-1-yl)-phenyl]-3H-quinazolin-4-one; 6-chloro-3-(5-chloro-pyridin-2-yl)-2-[4-(2-oxo-imidazolidin-1-yl)-phenyl]-3H-quinazolin-4-one; 6-chloro-3-(4-chloro-phenyl)-2-[4-(2-oxo-imidazolidin-1-yl)-phenyl]-3H-quinazolin-4-one; 6-chloro-3-(4-methoxy-phenyl)-2-[4-(2-oxo-imidazolidin-1-yl)-phenyl]-3H-quinazolin-4-one; 6-chloro-3-(5-chloro-pyridin-2-yl)-2-[4-(2-oxo-tetrahydro-pyrimidin-1-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-6-methoxy-2-[4-(2-oxo-tetrahydro-pyrimidin-1-yl)-phenyl]-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(2-dimethylaminomethyl-4,5-dihydro-imidazol-1-yl)-phenyl]-6-methoxy-3H-quinazolin-4-one; 3-(4-chloro-phenyl)-2-[4-(2-dimethylaminomethyl-4,5-dihydro-imidazol-1-yl)-phenyl]-6-methoxy-3H-quinazolin-4-one; 6-chloro-3-(4-chloro-phenyl)-2-[4-(2-dimethylaminomethyl-4,5-dihydro-imidazol-1-yl)-phenyl]-3H-quinazolin-4-one; 6-bromo-3-(4-chloro-phenyl)-2-[4-(2-dimethylaminomethyl-4,5-dihydro-imidazol-1-yl)-phenyl]-3H-quinazolin-4-one; 2-[4-(2-dimethylaminomethyl-4,5-dihydro-imidazol-1-yl)-phenyl]-3-(4-methoxy-phenyl)-6-methyl-3H-quinazolin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1H-pyrrol-2-yl)-phenyl]-3H-pyrido[3,2-d]pyrimidin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-methyl-1H-pyrrol-2-yl)-phenyl]-3H-pyrido[3,2-d]pyrimidin-4-one; 3-(5-chloro-pyridin-2-yl)-2-{4-[1-(2-methylamino-ethyl)-1H-pyrrol-2-yl]-phenyl}-3H-pyrido[3,2-d]pyrimidin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1H-pyrrol-2-yl)-phenyl]-3H-pyrido[4,3-d]pyrimidin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-methyl-1H-pyrrol-2-yl)-phenyl]-3H-pyrido[4,3-d]pyrimidin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1H-pyrrol-2-yl)-phenyl]-3H-pyrido[3,4-d]pyrimidin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1H-pyrrol-2-yl)-phenyl]-3H-thieno[3,4-d]pyrimidin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1H-imidazol-2-yl)-phenyl]-3H-pyrido[3,2-d]pyrimidin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1H-imidazol-2-yl)-phenyl]-3H-thieno[3,4-d]pyrimidin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(1-methyl-1H-imidazol-2-yl)-phenyl]-3H-thieno[3,4-d]pyrimidin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(2-oxo-tetrahydro-pyrimidin-1-yl)-phenyl]-3H-pyrido[3,2-d]pyrimidin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(2-oxo-tetrahydro-pyrimidin-1-yl)-phenyl]-3H-pyrido[4,3-d]pyrimidin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(2-oxo-tetrahydro-pyrimidin-1-yl)-phenyl]-3H-pyrido[3,4-d]pyrimidin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(2-oxo-tetrahydro-pyrimidin-1-yl)-phenyl]-3H-thieno[3 ,4-d]pyrimidin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(2-oxo-imidazolidin-1-yl)-phenyl]-3H-pyrido[3,2-d]pyrimidin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(2-oxo-imidazolidin-1-yl)-phenyl]-3H-pyrido[4,3-d]pyrimidin-4-one; 6-(5-chloro-pyridin-2-yl)-5-[4-(2-oxo-tetrahydro-pyrimidin-1-yl)-phenyl]-6H-[1,2,5]oxadiazolo[3,4-d]pyrimidin-7-one; 6-(5-chloro-pyridin-2-yl)-5-[4-(2-oxo-tetrahydro-pyrimidin-1-yl)-phenyl]-6H-isoxazolo[4,3-d]pyrimidin-7-one; 6-(5-chloro-pyridin-2-yl)-5-[4-(2-oxo-tetrahydro-pyrimidin-1-yl)-phenyl]-6H-thiazolo[5,4-d]pyrimidin-7-one; 1-(5-chloro-pyridin-2-yl)-7-methyl-2-[4-(2-oxo-tetrahydro-pyrimidin-1-yl)-phenyl]-1,7-dihydro-purin-6-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(2-oxo-imidazolidin-1-yl)-phenyl]-3H-thieno[3,2-d]pyrimidin-4-one; 3-(5-chloro-pyridin-2-yl)-5-methyl-2-[4-(2-oxo-imidazolidin-1-yl)-phenyl]-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one; 6-(5-chloro-pyridin-2-yl)-1-methyl-5-[4-(2-oxo-imidazolidin-1-yl)-phenyl]-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(3-dimethylamino-2-oxo-piperidin-1-yl)-phenyl]-3H-furo[3,2-d]pyrimidin-4-one; 3-(5-chloro-pyridin-2-yl)-2-[4-(3-dimethylamino-2-oxo-piperidin-1-yl)-phenyl]-5-methyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one; and, 6-(5-chloro-pyridin-2-yl)-5-[4-(3-dimethylamino-2-oxo-piperidin-1-yl)-phenyl]-1-methyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one; or a pharmaceutically acceptable salt form thereof.
- 9. A method for treating a thromboembolic disorder, comprising: administering to a patient in need thereof a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof.
- 10. A method according to claim 9, wherein the thromboembolic disorder is selected from the group consisting of arterial cardiovascular thromboembolic disorders, venous cardiovascular thromboembolic disorders, and thromboembolic disorders in the chambers of the heart.
- 11. A method according to claim 9, wherein the thromboembolic disorder is selected from unstable angina, an acute coronary syndrome, first myocardial infarction, recurrent myocardial infarction, ischemic sudden death, transient ischemic attack, stroke, atherosclerosis, peripheral occlusive arterial disease, venous thrombosis, deep vein thrombosis, thrombophlebitis, arterial embolism, coronary arterial thrombosis, cerebral arterial thrombosis, cerebral embolism, kidney embolism, pulmonary embolism, and thrombosis resulting from (a) prosthetic valves or other implants, (b) indwelling catheters, (c) stents, (d) cardiopulmonary bypass, (e) hemodialysis, and (f) other procedures in which blood is exposed to an artificial surface that promotes thrombosis.
- 12. A method of treating a patient in need of thromboembolic disorder treatment, comprising: administering a compound of claim 1 or a pharmaceutically acceptable salt thereof in an amount effective to treat a thromboembolic disorder.
- 13. A method, comprising: administering a compound of claim 1 or a pharmaceutically acceptable salt thereof in an amount effective to treat a thromboembolic disorder.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] The present application claims the priority benefit of U.S. Provisional Application No. 60/420,098, filed Oct. 21, 2002, which is expressly incorporated fully herein by reference.
Provisional Applications (1)
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Number |
Date |
Country |
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60420098 |
Oct 2002 |
US |
Patent Application
20040132732
