Claims
- 1. A compound having the formula: ##STR7## wherein p is 0-3;
- R.sup.1 is hydrogen or lower alkyl;
- R.sup.2 is H or ##STR8## R.sup.3 is H, lower alkyl or perfluoro lower alkyl; R.sup.4 is phenyl, pyridyl or thienyl;
- R.sup.5 is hydrogen, lower alkyl, phenyl or pyridyl;
- R.sup.6 is ##STR9## --SO.sub.2 R.sup.3, --SO.sub.2 N(R.sup.3).sub.2, lower alkynyl or lower alkyl carbonyl prolinate;
- B is OR.sup.1 or N(R.sup.5).sub.2 ;
- m is 0-2;
- and the pharmaceutically acceptable salts thereof.
- 2. The compound of claim 1, which is (1R)-1-[3-[(2-quinolinyl)methoxy]phenyl]-2-(N-methyl-N-diethylcarbamoyl)amino ethanol.
- 3. The compound of claim 1, which is (1R)-1-[3-[(2-quinolinyl)methoxy]phenyl]-2-[N-methyl-N-(4-pyridonyl)]amino ethanol.
- 4. The compound of claim 1, which is (1R)-1-[3-[(2-quinolinyl)methoxy]phenyl]-2-(N-methyl-N-diphenylcarbamoyl)amino ethanol.
- 5. The compound of claim 1, which is (1R)-1-[3-[(2-quinolinyl)methoxy]phenyl]-2-(N-methyl-N-dimethylcarbamoyl)amino ethanol.
- 6. The compound of claim 1, which is (1R)-1-[3-[(2-quinolinyl)methoxy]phenyl]-2-(N-ethyl-N-diethylcarbamoyl)amino ethanol.
- 7. The compound of claim 1, which is (1R)-1-[3-[(2-quinolinyl)methoxy]phenyl]-2-(N-methyl-N-dimethylsulfamoyl)amino ethanol.
- 8. The compound of claim 1, which is (S)-1-[[[(R)-2-hydroxy-2-[3-(2-quinolinylmethoxy)phenyl]ethyl]methylamino]carbonyl]-2-pyrrolidine carboxylic acid, methyl ester.
- 9. The compound of claim 1, which is (1S)-1-[3-[(2-quinolinyl)methoxy]phenyl]-2-(N-methyl-N-diethylcarbamoyl)amino ethanol.
- 10. The compound of claim 1, which is (1R)-1-[3-[(2-quinolinyl)methoxy]phenyl]-2-(N-methyl-N-ethylcarboxylate)amino ethanol.
- 11. The compound of claim 1, which is 1-[3-[(2-quinolinyl)methoxy]phenyl]-2-(N-ethylcarboxylate)amino ethanol.
- 12. The compound of claim 1, which is (1R)-1-[3-[(2-quinolinyl)methoxy]phenyl]-2-(N-ethylcarbamoyl)amino ethanol.
- 13. The compound of claim 1, which is (1R)-1-[3-[(2-quinolinyl)methoxy]phenyl]-2-(N-methylcarbamoyl)amino ethanol.
- 14. The compound of claim 1, which is ethylcarbamic acid (1R)-2-[[(ethylamino)carbonyl]methylamino]-1-[3-(2-quinolinylmethoxy)phenyl]ethyl ester.
- 15. The compound of claim 1, which is N-[2-hydroxy-2-[3-(2-quinolinylmethoxy)phenyl]ethyl]-2-pyridine carboxamide.
- 16. The compound of claim 1, which is N-[2-hydroxy-2-[3-(2-quinolinyl)phenyl]ethyl]benzamide.
- 17. The compound of claim 1, which is N-[2-hydroxy-2-[3-(2-quinolinylmethoxy)phenyl]ethyl]-2-thiophene carboxamide.
- 18. The compound of claim 1, which is 3-[[2-hydroxy-2-[3-(2-quinolinylmethoxy)phenyl]ethyl]amino]-3-oxapropanoic acid, ethyl ester.
- 19. The compound of claim 1, which is .alpha.-[[methyl-(2-propynyl)amino]methyl]-3-(2-quinolinylmethoxy)benzene methanol.
- 20. The compound of claim 1, which is 1,1,1-trifluoro-N-[2-hydroxy-2-[3-(2-quinolinylmethoxy)phenyl]ethyl]methane sulfonamide.
Parent Case Info
This application is a continuation-in-part of U.S. Ser. No. 729,509, filed May 2, 1985, abandoned.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
4532349 |
Lang et al. |
Jul 1985 |
|
4661499 |
Young et al. |
Apr 1987 |
|
4761419 |
Picard et al. |
Aug 1988 |
|
4788204 |
Benevides et al. |
Nov 1988 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
729509 |
May 1985 |
|