Claims
- 1. A compound of the formula ##STR15## where: A is O or S;
- D is O, S, NR.sub.1, ##STR16## or a chemical bond E is a chemical bond or ##STR17## a is 0-2; b is 0-1;
- d is 1-5;
- e is 0-4;
- f is 0-5;
- n is 0-2;
- R is independently hydrogen, alkyl, hydroxy, alkoxy, carboxy, carbalkoxy, halo, nitro, haloalkyl, cyano or acyl;
- R' is independently hydrogen, alkyl, hydroxy, alkoxy, halo or haloalkyl;
- R.sub.1 is independently hydrogen, alkyl or aralkyl;
- R.sub.2 is --(CH.sub.2).sub.x --X;
- x is 0-3;
- X is hydrogen, alkyl, alkenyl, cycloalkyl, aryl, aralkyl, hydroxy, alkoxy, aralkoxy, amino, mono-and di-alkylamino, aralkylamino, acylamino, carbamyl, carboxy, carbalkoxy, tetrazolyl or acylsulfonamido;
- vicinal R.sub.2 groups together may be --(CH.sub.2).sub.y --, where y is 1-4, thus forming a 3-6 membered ring;
- geminal R.sub.1 and R.sub.2 groups may together form a spiro substituent, --(CH.sub.2).sub.z --, where z is 2 to 5;
- geminal R.sub.1 or R.sub.1 and R.sub.2 groups may together form an alkylidenyl substituent, .dbd.CHR.sub.1 ;
- Z is --COOR.sub.1, CN, ##STR18## --OR.sub.1 tetrazolyl or substituted tetrazolyl where the substituent may be alkyl, carboxyalkyl or carbalkoxyalkyl;
- R.sub.3 is hydrogen, alkyl, haloalkyl, phenyl or benzyl; and pharmaceutically acceptable salts thereof.
- 2. A compound according to claim 1 where:
- A is O or S;
- n is 0-1;
- a+b is 1;
- e+f is 0-5;
- R and R' are hydrogen, alkyl or alkoxy;
- R.sub.1 is hydrogen or alkyl;
- R.sub.2 is --(CH.sub.2).sub.x --X;
- x is 0-3;
- X is hydrogen or alkyl; and
- Z is --COOR.sub.1, --CN, ##STR19## or tetrazolyl.
- 3. A compound according to claim 2 where:
- A is 0;
- n is 0;
- d is 1-3; and
- Z is --COOR.sub.1, --CN or tetrazolyl.
- 4. A compound according to claim 3 where:
- a is 1;
- b is 0; and
- d is 1.
- 5. A compound according to claim 3 where:
- a is 1;
- b is 0; and
- d is 2.
- 6. A compound according to claim 3 where:
- a is 1;
- b is 0; and
- d is 3.
- 7. A compound according to claim 3 where:
- D is O; and
- E is a chemical bond.
- 8. A compound according to claim 3 where:
- D is S; and
- E is a chemical bond.
- 9. A compound according to claim 3 where:
- e+f is 0;
- D is a chemical bond; and
- E is a chemical bond.
- 10. A compound according to claim 3 where:
- e+f is 1-5;
- D is a chemical bond; and
- E is a chemical bond.
- 11. A compound according to claim 4 which is 5-(3-(3-(2-quinolinylmethyloxy)benzyl)phenyl)tetrazole.
- 12. A compound according to claim 5 which is 5-(4-(4-(2-quinolinylmethyloxy)phenethyl)phenyl)tetrazole.
- 13. A compound according to claim 5 which is 5-(4-(3-(2-quinolinylmethyloxy)phenethyl)phenyltetrazole.
- 14. A compound according to claim 4 which is 5-(3-methoxy-4-(3-(2-quinolinylmethyloxy)benzyl)phenyl)tetrazole.
- 15. A compound according to claim 4 which is 5-(4-methoxy-3-(3-(2-quinolinylmethyloxy)benzyl)phenyl)tetrazole.
- 16. A compound according to claim 4 which is 5-(4-(4-(2-quinolinylmethyloxy)benzyl)phenyl)tetrazole.
- 17. A compound according to claim 10 which is 5-(4-(4-(2-quinolinylmethyloxy)benzyl)benzyl)tetrazole.
- 18. A compound according to claim 10 which is 5-(4-(3-(4-(2-quinolinylmethyloxy)b.enzyl)phenyl)3-methylbutyl)tetrazole.
- 19. A compound according to claim 5 which is 5-(3-(3-(2-quinolinylmethyloxy)phenethyl)phenyl)tetrazole.
- 20. A compound according to claim 5 which is 5-(2-(3-(2-quinolinylmethyloxy)phenethyl)phenyl)tetrazole.
- 21. A method for the treatment of hypersensitive ailments in humans and mammals comprising administering thereto an effective amount of a compound of the formula according to claim 1.
- 22. A pharmaceutical composition wherein the active ingredient is a compound according to claim 1 in admixture with a pharmaceutical carrier
CROSS REFERENCE TO RELATED APPLICATION
This is a continuation-in-part application of U.S. application Ser. No. 07/116,428, filed Nov. 3, 1987, now U.S. Pat. No. 4,920,133, issued Apr. 24, 1990.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/US88/03895 |
11/1/1988 |
|
|
4/20/1990 |
4/20/1990 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO89/04303 |
5/18/1989 |
|
|
US Referenced Citations (4)
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
116428 |
Nov 1987 |
|