Claims
- 1. A compound of Formula (I):
- 2. The compound according to claim 1 wherein L is a direct bond.
- 3. The compound according to claim 1 wherein L is C1-4alkyldiyl.
- 4. The compound according to claim 1 wherein R3 is phenyl.
- 5. The compound according to claim 1 wherein R3 is pyridyl.
- 6. The compound according to claim 1 wherein R3 is thienyl.
- 7. The compound according to claim 1 wherein n is 1.
- 8. The compound according to claim 1 wherein n is 2 or 3 and R4 is C1-12alkanyl.
- 9. The compound according to claim 1 wherein R4 is —N(R5)(R6).
- 10. The compound according to claim 9 wherein R5 and R6 are different.
- 11. The compound according to claim 1 wherein L is Cl-4alkyldiyl, R3 is phenyl, n is 1 and R4 is C1-12alkanyl.
- 12. The compound according to claim 1 wherein R3 is phenyl, n is 1 and R4 is —N(R5)(R6).
- 13. The compound according to claim 1 wherein R3 is phenyl, n is 2 or 3, and two R4 substituents taken together form a C3-14 cyclic heteroalkyl or C3-14 cyclic alkyl.
- 14. The compound according to claim 1 wherein Z is O.
- 15. The compound according to claim 1 wherein m is 0.
- 16. The compound according to claim 1 wherein R2 is hydrogen.
- 17. A compound of Formula (I):
- 18. The compound according to claim 17 wherein R3 is phenyl.
- 19. The compound according to claim 17 wherein R3 is pyridyl.
- 20. The compound according to claim 17 wherein R3 is thienyl.
- 21. The compound according to claim 17 wherein n is 1.
- 22. The compound according to claim 17 wherein n is 2 or 3 and R4 is C1-12alkanyl.
- 23. The compound according to claim 17 wherein R4 is —N(R5)(R6).
- 24. The compound according to claim 23 wherein R5 and R6 are different.
- 25. The compound according to claim 17 wherein L is C1-4alkyldiyl, R3 is phenyl, n is 1 and R4 is C-1-12alkanyl.
- 26. The compound according to claim 17 wherein R3 is phenyl, n is 1 and R4 is —N(R5)(R6).
- 27. The compound according to claim 17 wherein R3 is phenyl, n is 2 or 3, and two R4 substituents taken together form a C3-14 cyclic heteroalkyl or C3-14 cyclic alkyl.
- 28. The compound according to claim 17 wherein Z is O.
- 29. The compound according to claim 17 wherein m is 0.
- 30. The compound according to claim 17 wherein R2 is hydrogen.
- 31. A compound of Formula (I):
- 32. The compound according to claim 31 wherein L is a direct bond.
- 33. The compound according to claim 31 wherein L is C1-4alkyldiyl.
- 34. The compound according to claim 31 wherein R3 is phenyl.
- 35. The compound according to claim 31 wherein R3 is pyridyl.
- 36. The compound according to claim 31 wherein R3 is thienyl.
- 37. The compound according to claim 31 wherein R4 is C1-12alkanyl.
- 38. The compound according to claim 31 wherein R4 is —N(R5)(R6).
- 39. The compound according to claim 38 wherein R5 and R6 are different.
- 40. The compound according to claim 31 wherein L is C1-4alkyldiyl, R3 is phenyl, and one R4 is C1-12alkanyl.
- 41. The compound according to claim 31 wherein R3 is phenyl, and one R4 is —N(R5)(R6).
- 42. The compound according to claim 31 wherein R3 is phenyl and two R4 substituents taken together form a C3-14 cyclic heteroalkyl or C3-14 cyclic alkyl.
- 43. The compound according to claim 31 wherein Z is O.
- 44. The compound according to claim 31 wherein m is 0.
- 45. The compound according to claim 31 wherein R2 is hydrogen.
- 46. A compound of Formula (I):
- 47. The compound according to claim 46 wherein L is a direct bond.
- 48. The compound according to claim 46 wherein L is C1-4alkyldiyl.
- 49. The compound according to claim 46 wherein R3 is phenyl.
- 50. The compound according to claim 46 wherein R3 is pyridyl.
- 51. The compound according to claim 46 wherein R3 is thienyl.
- 52. The compound according to claim 46 wherein R4 is C1-12alkanyl.
- 53. The compound according to claim 46 wherein R4 is —N(R5)(R6).
- 54. The compound according to claim 46 wherein R5 and R6 are different.
- 55. The compound according to claim 46 wherein L is C1-4alkyldiyl, R3 is phenyl, and one R4 is C1-12alkanyl.
- 56. The compound according to claim 46 wherein R3 is phenyl, and one R4 is —N(R5)(R6).
- 57. The compound according to claim 46 wherein R3 is phenyl and two R4 substituents taken together form a C3-14 cyclic heteroalkyl or C3-14 cyclic alkyl.
- 58. The compound according to claim 46 wherein Z is O.
- 59. The compound according to claim 46 wherein m is 0.
- 60. The compound according to claim 46 wherein R2 is hydrogen.
- 61. A compound of Formula (I):
- 62. The compound according to claim 61 wherein R3 is phenyl.
- 63. The compound according to claim 61 wherein R3 is pyridyl.
- 64. The compound according to claim 61 wherein R3 is thienyl.
- 65. The compound according to claim 61 wherein n is 1.
- 66. The compound according to claim 61 wherein n is 2 or 3 and R4 is C1-12alkanyl.
- 67. The compound according to claim 61 wherein n is 2, one R4 is halogen, and the other R4 is C1-6 fluorinated alkanyl.
- 68. The compound according to claim 61 wherein R4 is C1-6 fluorinated alkanyl.
- 69. The compound according to claim 61 R4 is halogen.
- 70. The compound according to claim 61 wherein R4 is —N(R5)(R6).
- 71. The compound according to claim 67 wherein R5 and R6 are different.
- 72. The compound according to claim 61 wherein L is C1-4alkyldiyl, R3 is phenyl, n is 1 and R4 is C1-12alkanyl.
- 73. The compound according to claim 61 wherein R3 is phenyl, n is 1 and R4 is —N(R5)(R6).
- 74. The compound according to claim 61 wherein R3 is phenyl, n is 2 or 3, and two R4substituents taken together form a C3-14 cyclic heteroalkyl or C3-14 cyclic alkyl.
- 75. The compound according to claim 61 wherein Z is O.
- 76. The compound according to claim 61 wherein m is 0.
- 77. The compound according to claim 61 wherein R2 is hydrogen.
- 78. A compound of Formula (I):
- 79. The compound according to claim 78 wherein L is a direct bond.
- 80. The compound according to claim 78 wherein R3 is pyridyl.
- 81. The compound according to claim 78 wherein R3 is thienyl.
- 82. The compound according to claim 78 wherein R3 is furyl.
- 83. The compound according to claim 78 wherein R3 is cyclohexyl.
- 84. The compound according to claim 78 wherein n is 1.
- 85. The compound according to claim 78 wherein n is 2 or 3 and R4 is C1-12alkanyl.
- 86. The compound according to claim 78 wherein R4 is —N(R5)(R6).
- 87. The compound according to claim 86 wherein R5 and R6 are different.
- 88. The compound according to claim 78 wherein Z is O.
- 89. The compound according to claim 78 wherein m is 0.
- 90. The compound according to claim 78 wherein R2 is hydrogen.
- 91. A compound selected from the group consisting of
1-Acetyl-2,3-dihydro-1H-indole-5-carboxylic acid quinolin-3-ylamide; 1-Benzoyl-2,3-dihydro-1H-indole-5-carboxylic acid quinolin-3-ylamide; 1-Butyryl-2,3-dihydro-1H-indole-5-carboxylic acid quinolin-3-ylamide; 1-Cyclohexanecarbonyl-2,3-dihydro-1H-indole-5-carboxylic acid quinolin-3-ylamide; 1-Cyclohexyl-2,3-dihydro-1H-indole-5-carboxylic acid quinolin-3-ylamide; 1-Isopropyl-2-trifluoromethyl-1H-benzoimidazole-5-carboxylic acid quinolin-3-ylamide; 1-Methyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid quinolin-3-ylamide; 1-Methyl-2,3-dihydro-1H-indole-5-carboxylic acid quinolin-3-ylamide; 1-Pentyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid quinolin-3-ylamide; 1-Pentyl-1H-indole-5-carboxylic acid quinolin-3-ylamide; 1-Pentyl-2,3-dihydro-1H-indole-5-carboxylic acid quinolin-3-ylamide; 1-Propyl-2,3-dihydro-1H-indole-5-carboxylic acid quinolin-3-ylamide; 2-(4-Dipentylamino-phenyl)-N-quinolin-3-yl-acetamide; 2-(4-Pentyl-phenyl)-N-quinolin-3-yl-acetamide; 2-(4-tert-Butyl-phenyl)-N-quinolin-3-yl-acetamide; 2-(Heptyl-methyl-amino)-N-quinolin-3-yl-benzamide; 2-(Methyl-pentyl-amino)-N-quinolin-3-yl-benzamide; 2,3-Dihydro-1H-indole-5-carboxylic acid quinolin-3-ylamide; 2-{4-(Methyl-pentyl-amino)-phenyl}-N-quinolin-3-yl-acetamide; 2-Chloro-4-(cyclohexylmethyl-amino)-N-quinolin-3-yl-benzamide; 2-Chloro-4-pentylamino-N-quinolin-3-yl-benzamide; 2-Heptylamino-N-quinolin-3-yl-benzamide; 2-Pentylamino-N-quinolin-3-yl-benzamide; 3-(1-Cyclohexyl-2,3-dihydro-1H-indol-5-yl)-N-quinolin-3-yl-propionamide; 3-(1-Cyclohexylmethyl-2,3-dihydro-1H-indol-5-yl)-N-quinolin-3-yl-propionamide; 3-(1-Propyl-1H-indol-5-yl)-N-quinolin-3-yl-propionamide, 3-(1-Propyl-2,3-dihydro-1H-indol-5-yl)-N-quinolin-3-yl-propionamide; 3-(2,2-Dimethyl-chroman-6-yl)-N-quinolin-3-yl-acrylamide; 3-(2,2-Dimethyl-chroman-6-yl)-N-quinolin-3-yl-propionamide; 3-(4-Azepan-1-yl-phenyl)-N-quinolin-3-yl-acrylamide; 3-(4-Azepan-1-yl-phenyl)-N-quinolin-3-yl-propionamide; 3-(4-Cyclohexylmethyl-phenyl)-N-quinolin-3-yl-propionamide; 3-(4-Dipentylamino-phenyl)-N-quinolin-3-yl-propionamide; 3-(4-Pentyl-phenyl)-N-quinolin-3-yl-acrylamide; 3-(4-Pentyl-phenyl)-N-quinolin-3-yl-propionamide; 3-(4-sec-Butyl-phenyl)-N-quinolin-3-yl-propionamide; 3-(4-tert-Butyl-phenyl)-N-quinolin-3-yl-acrylamide; 3-(4-tert-Butyl-phenyl)-N-quinolin-3-yl-propionamide; 3-(Cyclohexyl-methyl-amino)-N-quinolin-3-yl-benzamide; 3-(Heptyl-methyl-amino)-N-quinolin-3-yl-benzamide; 3-(Methyl-pentyl-amino)-N-quinolin-3-yl-benzamide; 3,4,5,6-Tetrahydro-2H-[1,2′]bipyridinyl-5′-carboxylic acid quinolin-3-ylamide; 3,4,5,6-Tetrahydro-2H-{1,2′}bipyridinyl-5′-carboxylic acid quinolin-3-ylamide; 3-[4-(Methyl-phenethyl-amino)-phenyl]-N-quinolin-3-yl-propionamide; 3-{4-(1,1-Dimethyl-3-phenyl-propyl)-phenyl}-N-quinolin-3-yl-propionamide; 3-{4-(1,1-Dimethyl-pentyl)-2,6-dimethoxy-phenyl}-N-quinolin-3-yl-propionamide; 3-{4-(1,1-Dimethyl-pentyl)-phenyl}-N-quinolin-3-yl; 3-{4-(1,1-Dimethyl-propyl)-2,6-dimethoxy-phenyl}-N-quinolin-3-yl-propionamide; 3-{4-(1,1-Dimethyl-propyl)-phenyl}-N-quinolin-3-yl-propionamide; 3-{4-(1-Cyclohexyl-1-methyl-ethyl)-phenyl}-N-quinolin-3-yl-propionamide; 3-{4-(1-Methyl-pentyl)-phenyl}-N-quinolin-3-yl-propionamide; 3-{4-(1-Methyl-pentyl)-phenyl}-N-quinolin-3-yl-propionamide; 3-{4-(Benzyl-methyl-amino)-phenyl}-N-quinolin-3-yl-propionamide; 3-{4-(Cyclohexyl-methyl-amino)-phenyl}-N-quinolin-3-yl-acrylamide; 3-{4-(Cyclohexyl-methyl-amino)-phenyl}-N-quinolin-3-yl-propionamide; 3-{4-(Cyclohexyl methyl-methyl-amino)-phenyl}-N-quinolin-3-yl-propionamide; 3-{4-(Methyl-pentyl-amino)-phenyl}-N-quinolin-3-yl-acrylamide; 3-{4-(Methyl-pentyl-amino)-phenyl}-N-quinolin-3-yl-propionamide; 3-{4-(Methyl-propyl-amino)-phenyl}-N-quinolin-3-yl-propionamide; 3-{5-(1,1-Dimethyl-propyl)-thiophen-2-yl}-N-quinolin-3-yl-propionamide; 3-Cyclohexylamino-N-quinolin-3-yl-benzamide; 3-Dipentylamino-N-quinolin-3-yl-benzamide; 3-Heptylamino-N-quinolin-3-yl-benzamide; 3-Indan-5-yl-N-quinolin-3-yl-propionamide; 3-Methyl-4-(methyl-pentyl-amino)-N-quinolin-3-yl-benzamide; 3-Methyl-4-pentylamino-N-quinolin-3-yl-benzamide; 3-Pentylamino-N-quinolin-3-yl-benzamide; 4-(1,3-Dihydro-isoindol-2-yl)-N-quinolin-3-yl-benzamide; 4-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-N-quinolin-3-yl-benzamide; 4-(2,6-Dimethyl-morpholin-4-yl)-N-quinolin-3-yl-benzamide; 4-(3,5-Dimethyl-piperidin-1-yl)-N-quinolin-3-yl-benzamide; 4-(3-Aza-bicyclo{3.3.1}non-3-yl)-N-quinolin-3-yl-benzamide; 4-(3-Methyl-piperidin-1-yl)-N-quinolin-3-yl-benzamide; 4-(4-Benzoyl-piperidin-1-yl)-N-quinolin-3-yl-benzamide; 4-(4-Benzyl-piperidin-1-yl)-N-quinolin-3-yl-benzamide; 4-(4-Phenylacetyl-piperazin-1-yl)-N-quinolin-3-yl-benzamide; 4-(4-Phenyl-piperidin-1-yl)-N-quinolin-3-yl-benzamide; 4-(4-Propyl-piperidin-1-yl)-N-quinolin-3-yl-benzamide; 4-(Acetyl-cyclohexyl-amino)-N-quinolin-3-yl-benzamide; 4-(Benzyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Benzyl-pentyl-amino)-N-quinolin-3-yl-benzamide; 4-(Cycloheptyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Cyclohexanecarbonyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Cyclohexyl-ethyl-amino)-N-quinolin-3-yl-benzamide; 4-(Cyclohexyl methyl-amino)-3-methyl-N-quinolin-3-yl-benzamide; 4-(Cyclohexyl-methyl-amino)-3-methyl-N-quinolin-3-yl-benzamide; 4-(Cyclohexyl-methyl-amino)-N-methyl-N-quinolin-3-yl-benzamide; 4-(Cyclohexyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Cyclohexyl methyl-methyl-amino)-3-methyl-N-quinolin-3-yl-benzamide; 4-(Cyclohexyl methyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Cyclohexylmethyl-phenethyl-amino)-N-quinolin-3-yl-benzamide; 4-(Cyclohexyl-propyl-amino)-N-quinolin-3-yl-benzamide; 4-(Cyclopentyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Dec-4-enyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Hept-4-enyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Heptyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Methyl-butyl-amino)-N-quinolin-3-yl-benzamide; 4-(Methyl-hexyl-amino)-N-quinolin-3-yl-benzamide; 4-(Methyl-non-6-enyl-amino)-N-quinolin-3-yl-benzamide; 4-(Methyl-nonyl-amino)-N-quinolin-3-yl-benzamide; 4-(Methyl-pentyl-amino)-N-quinolin-3-yl-benzamide; 4-(Methyl-phenethyl-amino)-N-quinolin-3-yl-benzamide; 4-(Methyl-propyl-amino)-N-quinolin-3-yl-benzamide; 4-(Methyl-tetradecyl-amino)-N-quinolin-3-yl-benzamide; 4-(Octyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Phenethyl-propyl-amino)-N-quinolin-3-yl-benzamide; 4-[1,4′]Bipiperidinyl-1′-yl-N-quinolin-3-yl-benzamide; 4-{(3,3-Dimethyl-butyl)-methyl-amino}-N-quinolin-3-yl-benzamide; 4-{4-(1,1-Dimethyl-pentyl)-phenyl}-but-3-enoic acid quinolin-3-ylamide; 4-{4-(1,1-Dimethyl-pentyl)-phenyl}-N-quinolin-3-yl-butyramide; 4-{4-(1,1-Dimethyl-propyl)-phenyl}-but-3-enoic acid quinolin-3-ylamide; 4-{4-(1,1-Dimethyl-propyl)-phenyl}-N-quinolin-3-yl-butyramide; 4-{Methyl-(3-methyl-butyl)-amino}-N-quinolin-3-yl-benzamide; 4-{Methyl-(3-phenyl-allyl)-amino}-N-quinolin-3-yl-benzamide; 4-{Methyl-(3-phenyl-propyl)-amino}-N-quinolin-3-yl-benzamide; 4-{Methyl-(tetrahydro-pyran4-yl)-amino}-N-quinolin-3-yl-benzamide; 4-{Methyl-{3-(5-methyl-furan-2-yl)-butyl}-amino}-N-quinolin-3-yl-benzamide; 4-Azepan-1-yl-N-quinolin-3-yl-benzamide; 4-Azepan-1-yl-N-quinolin-3-yl-benzamide; 4-Azocan-1-yl-N-quinolin-3-yl-benzamide; 4-Azonan-1-yl-N-quinolin-3-yl-benzamide; 4-Benzyl-3,4,5,6-tetrahydro-2H-{1,2′}bipyridinyl-5′-carboxylic acid quinolin-3-ylamide; 4-Butoxy-N-quinolin-3-yl-benzamide; 4-Butyl-cyclohexanecarboxylic acid quinolin-3-ylamide; 4-Butyl-cyclohexanecarboxylic acid quinolin-3-ylamide; 4-Cycloheptylamino-N-quinolin-3-yl-benzamide; 4-Cyclohexylamino-N-methyl-N-quinolin-3-yl-benzamide; 4-Cyclohexylamino-N-quinolin-3-yl-benzamide; 4-Cyclopentylamino-N-quinolin-3-yl-benzamide; 4-Dibenzylamino-N-quinolin-3-yl-benzamide; 4-Dibutylamino-N-quinolin-3-yl-benzamide; 4-Dihexylamino-N-quinolin-3-yl-benzamide; 4-Dipentylamino-N-quinolin-3-yl-benzamide; 4-Dipropylamino-N-quinolin-3-yl-benzamide; 4-Morpholin-4-yl-N-quinolin-3-yl-benzamide; 4-Pentylamino-N-quinolin-3-yl-benzamide; 4-Phenethylamino-N-quinolin-3-yl-benzamide; 4-Piperazin-1-yl-N-quinolin-3-yl-benzamide; 4-Piperidin-1-yl-N-quinolin-3-yl-benzamide; 4-Propyl-3,4,5,6-tetrahydro-2H-{1,2′}bipyridinyl-5′-carboxylic acid quinolin-3-ylamide; 4-Pyrrolidin-1-yl-N-quinolin-3-yl-benzamide; 4-tert-Butyl-cyclohexanecarboxylic acid quinolin-3-ylamide; 4-tert-Butyl-cyclohexanecarboxylic acid quinolin-3-ylamide; 5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid quinolin-3-ylamide; 5,6,7,8-Tetrahydro-naphthalene-2-carboxylic acid quinolin-3-ylamide; 5-Chloro-1H-indole-2-carboxylic acid quinolin-3-ylamide; 5-Pentyl-thiophene-2-carboxylic acid quinolin-3-ylamide; 6-(3-Aza-bicyclo{3.3.1}non-3-yl)-N-quinolin-3-yl-nicotinamide; 6-(Benzyl-methyl-amino)-N-quinolin-3-yl-nicotinamide; 6-(Cyclohexyl-methyl-amino)-N-quinolin-3-yl-nicotinamide; 6-(Cyclohexyl-methyl-amino)-N-quinolin-3-yl-nicotinamide; 6-(Heptyl-methyl-amino)-N-quinolin-3-yl-nicotinamide; 6-(Methyl-pentyl-amino)-N-quinolin-3-yl-nicotinamide; 6-(Methyl-phenethyl-amino)-N-quinolin-3-yl-nicotinamide; 6-Azepan-1-yl-N-quinolin-3-yl-nicotinamide; 6-Azocan-1-yl-N-quinolin-3-yl-nicotinamide; 6-Cyclohexylamino-N-quinolin-3-yl-nicotinamide; 6-Pentylamino-N-quinolin-3-yl-nicotinamide; cis-4-(Octahydro-isoquinolin-2-yl)-N-quinolin-3-yl-benzamide; cis-6-(Octahydro-isoquinolin-2-yl)-N-quinolin-3-yl-nicotinamide; N-Quinolin-3-yl-3-(3-trifluoromethyl-phenyl)-acrylamide; N-Quinolin-3-yl-3-(4-tricyclo{5.3.1.13,9}dodec-1-yl-phenyl)-propionamide; N-Quinolin-3-yl-3-(4-trifluoromethyl-phenyl)-acrylamide; N-Quinolin-3-yl-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propionamide; N-Quinolin-3-yl-3-(5,6,7,8-tetrahydro-naphthalen-2-yl)-propionamide; N-Quinolin-3-yl-4-(tetrahydro-pyran4-ylamino)-benzamide; N-Quinolin-3-yl-4-thiomorpholin-4-yl-benzamide; R-4-{(3,7-Dimethyl-oct-6-enyl)-methyl-amino}-N-quinolin-3-yl-benzamide; S4-{(3,7-Dimethyl-oct-6-enyl)-methyl-amino}-N-quinolin-3-yl-benzamide; trans-4-(Octahydro-isoquinolin-2-yl)-N-quinolin-3-yl-benzamide; trans-6-(Octahydro-isoquinolin-2-yl)-N-quinolin-3-yl-nicotinamide; 4-tert-Butyl-N-(4-hydroxy-quinolin-3-yl)-benzamide; 3-(4-tert-Butyl-phenyl)-N-(4-hydroxy-quinolin-3-yl)-acrylamide; N-Quinolin-3-yl-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-acrylamide; N-(4-Chloro-quinolin-3-yl)-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-acrylamide; N-(4-Chloro-quinolin-3-yl)-4-(cyclohexyl-methyl-amino)-benzamide; N-(2-Chloro-quinolin-3-yl)-4-(cyclohexyl-methyl-amino)-benzamide; 4-tert-Butyl-N-(2-methoxy-quinolin-3-yl)-benzamide; 4-Azepan-1-yl-N-(4-chloro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(2-chloro-quinolin-3-yl)-benzamide; 4-Azepan-1-yl-N-(2-chloro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(4-chloro-quinolin-3-yl)-benzamide; 3-(1-Cyclohexyl-2,3-dihydro-1H-indol-5-yl)-N-quinolin-3-yl-acrylamide; 1-Cyclohexyl-2,3-dihydro-1H-indole-5-carboxylic acid (2-chloro-quinolin-3-yl)-amide; N-(2-Chloro-quinolin-3-yl)-3-(1-cyclohexyl-2,3-dihydro-1H-indol-5-yl)-acrylamide; 3-(1-Cyclohexyl-1H-indol-5-yl)-N-quinolin-3-yl-acrylamide; N-(4-Chloro-quinolin-3-yl)-3-(1-cyclohexyl-1H-indol-5-yl)-acrylamide; 1-Cyclohexyl-1H-indole-5-carboxylic acid (4-chloro-quinolin-3-yl)-amide; 1-Cyclohexyl-1H-indole-5-carboxylic acid quinolin-3-ylamide; 1-Cyclohexyl-1H-indole-5-carboxylic acid (2-chloro-quinolin-3-yl)-amide; N-(2-Chloro-quinolin-3-yl)-3-(1-cyclohexyl-1H-indol-5-yl)-acrylamide; 4-(Cyclohexyl-methyl-amino)-N-(8-fluoro-quinolin-3-yl)-benzamide; 4-Azocan-1-yl-N-(8-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(8-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(8-trifluoromethyl-quinolin-3-yl)-benzamide; 4-(Cyclohexyl-methyl-amino)-N-(8-trifluoromethyl-quinolin-3-yl)-benzamide; 4-(Cyclohexyl-methyl-amino)-N-(6-fluoro-quinolin-3-yl)-benzamide; 4-Azocan-1-yl-N-(6-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(6-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(7-trifluoromethyl-quinolin-3-yl)-benzamide; 4-Azocan-1-yl-N-(7-trifluoromethyl-quinolin-3-yl)-benzamide; 4-(Cyclohexyl-methyl-amino)-N-(7-trifluoromethyl-quinolin-3-yl)-benzamide; 4-Azocan-1-yl-N-(5-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(5-fluoro-quinolin-3-yl)-benzamide; 3-Phenyl-propynoic acid quinolin-3-ylamide; trans-2-Phenyl-cyclopropanecarboxylic acid quinolin-3-ylamide; 3-(4-tert-Butyl-phenyl)-propynoic acid quinolin-3-ylamide; and 2-(4-tert-Butyl-phenyl)-cyclopropanecarboxylic acid quinolin-3-ylamide.
- 92. A compound selected from the group consisting of
1-Cyclohexyl-2,3-dihydro-1H-indole-5-carboxylic acid quinolin-3-ylamide; 1-Pentyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid quinolin-3-ylamide; 1-Pentyl-2,3-dihydro-1H-indole-5-carboxylic acid quinolin-3-ylamide; 1-Propyl-2,3-dihydro-1H-indole-5-carboxylic acid quinolin-3-ylamide; 3-(4-sec-Butyl-phenyl)-N-quinolin-3-yl-propionamide; 3-(4-tert-Butyl-phenyl)-N-quinolin-3-yl-acrylamide; 3-(4-tert-Butyl-phenyl)-N-quinolin-3-yl-propionamide; 3,4,5,6-Tetrahydro-2H-{1,2′}bipyridinyl-5′-carboxylic acid quinolin-3-ylamide; 3-{4-(1,1-Dimethyl-3-phenyl-propyl)-phenyl}-N-quinolin-3-yl-propionamide; 3-{4-(1,1-Dimethyl-pentyl)-2,6-dimethoxy-phenyl}-N-quinolin-3-yl-propionamide; 3-{4-(1,1-Dimethyl-pentyl)-phenyl}-N-quinolin-3-yl; 3-{4-(1,1-Dimethyl-propyl)-2,6-dimethoxy-phenyl}-N-quinolin-3-yl-propionamide; 3-{4-(1,1-Dimethyl-propyl)-phenyl}-N-quinolin-3-yl-propionamide; 3-{4-(1-Cyclohexyl-1-methyl-ethyl)-phenyl}-N-quinolin-3-yl-propionamide; 3-{4-(1-Methyl-pentyl)-phenyl}-N-quinolin-3-yl-propionamide; 3-{5-(1,1-Dimethyl-propyl)-thiophen-2-yl}-N-quinolin-3-yl-propionamide; 4-(3-Aza-bicyclo{3.3.1}non-3-yl)-N-quinolin-3-yl-benzamide; 4-(4-Benzyl-piperidin-1-yl)-N-quinolin-3-yl-benzamide; 4-(Cycloheptyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Cyclohexyl-ethyl-amino)-N-quinolin-3-yl-benzamide; 4-(Cyclohexyl-methyl-amino)-3-methyl-N-quinolin-3-yl-benzamide; 4-(Cyclohexyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Cyclohexylmethyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Cyclopentyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Dec-4-enyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Hept-4-enyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Heptyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Methyl-non-6-enyl-amino)-N-quinolin-3-yl-benzamide; 4-(Methyl-nonyl-amino)-N-quinolin-3-yl-benzamide; 4-(Methyl-phenethyl-amino)-N-quinolin-3-yl-benzamide; 4-(Octyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-{(3,3-Dimethyl-butyl)-methyl-amino}-N-quinolin-3-yl-benzamide; 4-{Methyl-{3-(5-methyl-furan-2-yl)-butyl}-amino}-N-quinolin-3-yl-benzamide; 4-Azepan-1-yl-N-quinolin-3-yl-benzamide; 4-Azepan-1-yl-N-quinolin-3-yl-benzamide; 4-Azocan-1-yl-N-quinolin-3-yl-benzamide; 4-Azonan-1-yl-N-quinolin-3-yl-benzamide; 4-Benzyl-3,4,5,6-tetrahydro-2H-{1,2′}bipyridinyl-5′-carboxylic acid quinolin-3-ylamide; 5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid quinolin-3-ylamide; 6-(3-Aza-bicyclo{3.3.1}non-3-yl)-N-quinolin-3-yl-nicotinamide; 6-Azocan-1-yl-N-quinolin-3-yl-nicotinamide; cis-4-(Octahydro-isoquinolin-2-yl)-N-quinolin-3-yl-benzamide; cis-6-(Octahydro-isoquinolin-2-yl)-N-quinolin-3-yl-nicotinamide; N-Quinolin-3-yl-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propionamide; R-4-{(3,7-Dimethyl-oct-6-enyl)-methyl-amino}-N-quinolin-3-yl-benzamide; S4-{(3,7-Dimethyl-oct-6-enyl)-methyl-amino}-N-quinolin-3-yl-benzamide; trans-4-(Octahydro-isoquinolin-2-yl)-N-quinolin-3-yl-benzamide; trans-6-(Octahydro-isoquinolin-2-yl)-N-quinolin-3-yl-nicotinamide; 4-tert-Butyl-N-(4-hydroxy-quinolin-3-yl)-benzamide; 3-(4-tert-Butyl-phenyl)-N-(4-hydroxy-quinolin-3-yl)-acrylamide; N-Quinolin-3-yl-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-acrylamide; N-(4-Chloro-quinolin-3-yl)-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-acrylamide; N-(4-Chloro-quinolin-3-yl)-4-(cyclohexyl-methyl-amino)-benzamide; N-(2-Chloro-quinolin-3-yl)-4-(cyclohexyl-methyl-amino)-benzamide; 4-tert-Butyl-N-(2-methoxy-quinolin-3-yl)-benzamide; 4-Azepan-1-yl-N-(4-chloro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(2-chloro-quinolin-3-yl)-benzamide; 4-Azepan-1-yl-N-(2-chloro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(4-chloro-quinolin-3-yl)-benzamide; 3-(1-Cyclohexyl-2,3-dihydro-1H-indol-5-yl)-N-quinolin-3-yl-acrylamide; 1-Cyclohexyl-2,3-dihydro-1H-indole-5-carboxylic acid (2-chloro-quinolin-3-yl)-amide; N-(2-Chloro-quinolin-3-yl)-3-(1-cyclohexyl-2,3-dihydro-1H-indol-5-yl)-acrylamide; 3-(1-Cyclohexyl-1H-indol-5-yl)-N-quinolin-3-yl-acrylamide; N-(4-Chloro-quinolin-3-yl)-3-(1-cyclohexyl-1H-indol-5-yl)-acrylamide; 1-Cyclohexyl-1H-indole-5-carboxylic acid (4-chloro-quinolin-3-yl)-amide; 1-Cyclohexyl-1H-indole-5-carboxylic acid quinolin-3-ylamide; 1-Cyclohexyl-1H-indole-5-carboxylic acid (2-chloro-quinolin-3-yl)-amide; N-(2-Chloro-quinolin-3-yl)-3-(1-cyclohexyl-1H-indol-5-yl)-acrylamide; 4-(Cyclohexyl-methyl-amino)-N-(8-fluoro-quinolin-3-yl)-benzamide; 4-Azocan-1-yl-N-(8-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(8-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(8-trifluoromethyl-quinolin-3-yl)-benzamide; 4-(Cyclohexyl-methyl-amino)-N-(8-trifluoromethyl-quinolin-3-yl)-benzamide; 4-(Cyclohexyl-methyl-amino)-N-(6-fluoro-quinolin-3-yl)-benzamide; 4-Azocan-1-yl-N-(6-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(6-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(7-trifluoromethyl-quinolin-3-yl)-benzamide; 4-Azocan-1-yl-N-(7-trifluoromethyl-quinolin-3-yl)-benzamide; 4-(Cyclohexyl-methyl-amino)-N-(7-trifluoromethyl-quinolin-3-yl)-benzamide; 4-Azocan-1-yl-N-(5-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(5-fluoro-quinolin-3-yl)-benzamide; 3-Phenyl-propynoic acid quinolin-3-ylamide; trans-2-Phenyl-cyclopropanecarboxylic acid quinolin-3-ylamide; 3-(4-tert-Butyl-phenyl)-propynoic acid quinolin-3-ylamide; and 2-(4-tert-Butyl-phenyl)-cyclopropanecarboxylic acid quinolin-3-ylamide.
- 93. A compound selected from the group consisting of
1-Cyclohexyl-2,3-dihydro-1H-indole-5-carboxylic acid quinolin-3-ylamide; 1-Pentyl-2,3-dihydro-1H-indole-5-carboxylic acid quinolin-3-ylamide; 1-Propyl-2,3-dihydro-1H-indole-5-carboxylic acid quinolin-3-ylamide; 3-(4-sec-Butyl-phenyl)-N-quinolin-3-yl-propionamide; 3-(4-tert-Butyl-phenyl)-N-quinolin-3-yl-acrylamide; 3-(4-tert-Butyl-phenyl)-N-quinolin-3-yl-propionamide; 3,4,5,6-Tetrahydro-2H-{1,2′}bipyridinyl-5′-carboxylic acid quinolin-3-ylamide; 3-{4-(1,1-Dimethyl-3-phenyl-propyl)-phenyl}-N-quinolin-3-yl-propionamide; 3-{4-(1,1-Dimethyl-pentyl)-2,6-dimethoxy-phenyl}-N-quinolin-3-yl-propionamide; 3-{4-(1,1-Dimethyl-propyl)-phenyl}-N-quinolin-3-yl-propionamide; 3-{4-(1-Methyl-pentyl)-phenyl}-N-quinolin-3-yl-propionamide; 3-{5-(1,1-Dimethyl-propyl)-thiophen-2-yl}-N-quinolin-3-yl-propionamide; 4-(3-Aza-bicyclo{3.3.1}non-3-yl)-N-quinolin-3-yl-benzamide; 4-(4-Benzyl-piperidin-1-yl)-N-quinolin-3-yl-benzamide; 4-(Cycloheptyl-methyl-amino)-N-quinolin-3-yl-benzamide;; 4-(Cyclohexyl-ethyl-amino)-N-quinolin-3-yl-benzamide; 4-(Cyclohexyl-methyl-amino)-3-methyl-N-quinolin-3-yl-benzamide; 4-(Cyclohexyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Cyclohexylmethyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Cyclopentyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Dec4-enyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Heptyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Methyl-nonyl-amino)-N-quinolin-3-yl-benzamide; 4-(Methyl-phenethyl-amino)-N-quinolin-3-yl-benzamide; 4-(Octyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-{(3,3-Dimethyl-butyl)-methyl-amino}-N-quinolin-3-yl-benzamide; 4-Azepan-1-yl-N-quinolin-3-yl-benzamide; 4-Azepan-1-yl-N-quinolin-3-yl-benzamide; 4-Azocan-1-yl-N-quinolin-3-yl-benzamide; 4-Azonan-1-yl-N-quinolin-3-yl-benzamide; 4-Benzyl-3,4,5,6-tetrahydro-2H-{1,2′}bipyridinyl-5′-carboxylic acid quinolin-3-ylamide; 6-(3-Aza-bicyclo{3.3.1}non-3-yl)-N-quinolin-3-yl-nicotinamide; N-Quinolin-3-yl-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propionamide; R4-{(3,7-Dimethyl-oct-6-enyl)-methyl-amino}-N-quinolin-3-yl-benzamide; S-4-{(3,7-Dimethyl-oct-6-enyl)-methyl-amino}-N-quinolin-3-yl-benzamide; 4-tert-Butyl-N-(4-hydroxy-quinolin-3-yl)-benzamide; 3-(4-tert-Butyl-phenyl)-N-(4-hydroxy-quinolin-3-yl)-acrylamide; N-Quinolin-3-yl-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-acrylamide; N-(4-Chloro-quinolin-3-yl)-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-acrylamide; N-(4-Chloro-quinolin-3-yl)-4-(cyclohexyl-methyl-amino)-benzamide; N-(2-Chloro-quinolin-3-yl)-4-(cyclohexyl-methyl-amino)-benzamide; 4-tert-Butyl-N-(2-methoxy-quinolin-3-yl)-benzamide; 4-Azepan-1-yl-N-(4-chloro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(2-chloro-quinolin-3-yl)-benzamide; 4-Azepan-1-yl-N-(2-chloro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(4-chloro-quinolin-3-yl)-benzamide; 3-(1-Cyclohexyl-2,3-dihydro-1H-indol-5-yl)-N-quinolin-3-yl-acrylamide; 1-Cyclohexyl-2,3-dihydro-1H-indole-5-carboxylic acid (2-chloro-quinolin-3-yl)-amide; N-(2-Chloro-quinolin-3-yl)-3-(1-cyclohexyl-2,3-dihydro-1H-indol-5-yl)-acrylamide; 3-(1-Cyclohexyl-1H-indol-5-yl)-N-quinolin-3-yl-acrylamide; N-(4-Chloro-quinolin-3-yl)-3-(1-cyclohexyl-1H-indol-5-yl)-acrylamide; 1-Cyclohexyl-1H-indole-5-carboxylic acid (4-chloro-quinolin-3-yl)-amide; 1-Cyclohexyl-1H-indole-5-carboxylic acid quinolin-3-ylamide; 1-Cyclohexyl-1H-indole-5-carboxylic acid (2-chloro-quinolin-3-yl)-amide; N-(2-Chloro-quinolin-3-yl)-3-(1-cyclohexyl-1H-indol-5-yl)-acrylamide; 4-(Cyclohexyl-methyl-amino)-N-(8-fluoro-quinolin-3-yl)-benzamide; 4-Azocan-1-yl-N-(8-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(8-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(8-trifluoromethyl-quinolin-3-yl)-benzamide; 4-(Cyclohexyl-methyl-amino)-N-(8-trifluoromethyl-quinolin-3-yl)-benzamide; 4-(Cyclohexyl-methyl-amino)-N-(6-fluoro-quinolin-3-yl)-benzamide; 4-Azocan-1-yl-N-(6-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(6-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(7-trifluoromethyl-quinolin-3-yl)-benzamide; 4-Azocan-1-yl-N-(7-trifluoromethyl-quinolin-3-yl)-benzamide; 4-(Cyclohexyl-methyl-amino)-N-(7-trifluoromethyl-quinolin-3-yl)-benzamide; 4-Azocan-1-yl-N-(5-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(5-fluoro-quinolin-3-yl)-benzamide; 3-Phenyl-propynoic acid quinolin-3-ylamide; trans-2-Phenyl-cyclopropanecarboxylic acid quinolin-3-ylamide; 3-(4-tert-Butyl-phenyl)-propynoic acid quinolin-3-ylamide; and 2-(4-tert-Butyl-phenyl)-cyclopropanecarboxylic acid quinolin-3-ylamide.
- 94. A compound selected from the group consisting of
1-Cyclohexyl-2,3-dihydro-1H-indole-5-carboxylic acid quinolin-3-ylamide; 1-Propyl-2,3-dihydro-1H-indole-5-carboxylic acid quinolin-3-ylamide; 3-(4-sec-Butyl-phenyl)-N-quinolin-3-yl-propionamide; 3-(4-tert-Butyl-phenyl)-N-quinolin-3-yl-acrylamide; 3-(4-tert-Butyl-phenyl)-N-quinolin-3-yl-propionamide; 3-{4-(1,1-Dimethyl-3-phenyl-propyl)-phenyl}-N-quinolin-3-yl-propionamide; 3-{4-(1,1-Dimethyl-pentyl)-2,6-dimethoxy-phenyl}-N-quinolin-3-yl-propionamide; 3-{4-(1,1-Dimethyl-propyl)-phenyl}-N-quinolin-3-yl-propionamide; 3-{4-(1-Methyl-pentyl)-phenyl}-N-quinolin-3-yl-propionamide; 3-{5-(1,1-Dimethyl-propyl)-thiophen-2-yl}-N-quinolin-3-yl-propionamide; 4-(3-Aza-bicyclo{3.3.1}non-3-yl)-N-quinolin-3-yl-benzamide; 4-(4-Benzyl-piperidin-1-yl)-N-quinolin-3-yl-benzamide; 4-(Cycloheptyl-methyl-amino)-N-quinolin-3-yl-benzamide;; 4-(Cyclohexyl-ethyl-amino)-N-quinolin-3-yl-benzamide; 4-(Cyclohexyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Cyclohexylmethyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-(Octyl-methyl-amino)-N-quinolin-3-yl-benzamide; 4-Azepan-1-yl-N-quinolin-3-yl-benzamide; 4-Azepan-1-yl-N-quinolin-3-yl-benzamide; 4-Azocan-1-yl-N-quinolin-3-yl-benzamide; 4-Azonan-1-yl-N-quinolin-3-yl-benzamide; 6-(3-Aza-bicyclo{3.3.1}non-3-yl)-N-quinolin-3-yl-nicotinamide; N-Quinolin-3-yl-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propionamide; R-4-{(3,7-Dimethyl-oct-6-enyl)-methyl-amino}-N-quinolin-3-yl-benzamide; S4-{(3,7-Dimethyl-oct-6-enyl)-methyl-amino}-N-quinolin-3-yl-benzamide; 5 4-tert-Butyl-N-(4-hydroxy-quinolin-3-yl)-benzamide; 3-(4-tert-Butyl-phenyl)-N-(4-hydroxy-quinolin-3-yl)-acrylamide; N-Quinolin-3-yl-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-acrylamide; N-(4-Chloro-quinolin-3-yl)-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-acrylamide; N-(4-Chloro-quinolin-3-yl)-4-(cyclohexyl-methyl-amino)-benzamide; N-(2-Chloro-quinolin-3-yl)-4-(cyclohexyl-methyl-amino)-benzamide; 4-tert-Butyl-N-(2-methoxy-quinolin-3-yl)-benzamide; 4-Azepan-1-yl-N-(4-chloro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(2-chloro-quinolin-3-yl)-benzamide; 4-Azepan-1-yl-N-(2-chloro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(4-chloro-quinolin-3-yl)-benzamide; 3-(1-Cyclohexyl-2,3-dihydro-1H-indol-5-yl)-N-quinolin-3-yl-acrylamide; 1-Cyclohexyl-2,3-dihydro-1H-indole-5-carboxylic acid (2-chloro-quinolin-3-yl)-amide; N-(2-Chloro-quinolin-3-yl)-3-(1-cyclohexyl-2,3-dihydro-1H-indol-5-yl)-acrylamide; 3-(1-Cyclohexyl-1H-indol-5-yl)-N-quinolin-3-yl-acrylamide; N-(4-Chloro-quinolin-3-yl)-3-(1-cyclohexyl-1H-indol-5-yl)-acrylamide; 1-Cyclohexyl-1H-indole-5-carboxylic acid (4-chloro-quinolin-3-yl)-amide; 1-Cyclohexyl-1H-indole-5-carboxylic acid quinolin-3-ylamide; 1-Cyclohexyl-1H-indole-5-carboxylic acid (2-chloro-quinolin-3-yl)-amide; N-(2-Chloro-quinolin-3-yl)-3-(1-cyclohexyl-1H-indol-5-yl)-acrylamide; 4-(Cyclohexyl-methyl-amino)-N-(8-fluoro-quinolin-3-yl)-benzamide; 4-Azocan-1-yl-N-(8-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(8-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(8-trifluoromethyl-quinolin-3-yl)-benzamide; 4-(Cyclohexyl-methyl-amino)-N-(8-trifluoromethyl-quinolin-3-yl)-benzamide; 4-(Cyclohexyl-methyl-amino)-N-(6-fluoro-quinolin-3-yl)-benzamide; 4-Azocan-1-yl-N-(6-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(6-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(7-trifluoromethyl-quinolin-3-yl)-benzamide; 4-Azocan-1-yl-N-(7-trifluoromethyl-quinolin-3-yl)-benzamide; 4-(Cyclohexyl-methyl-amino)-N-(7-trifluoromethyl-quinolin-3-yl)-benzamide; 4-Azocan-1-yl-N-(5-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(5-fluoro-quinolin-3-yl)-benzamide; 3-Phenyl-propynoic acid quinolin-3-ylamide; trans-2-Phenyl-cyclopropanecarboxylic acid quinolin-3-ylamide; 3-(4-tert-Butyl-phenyl)-propynoic acid quinolin-3-ylamide; and 2-(4-tert-Butyl-phenyl)-cyclopropanecarboxylic acid quinolin-3-ylamide.
- 95. A compound selected from the group consisting of
1-Cyclohexyl-2,3-dihydro-1H-indole-5-carboxylic acid quinolin-3-ylamide; 3-(4-tert-Butyl-phenyl)-N-quinolin-3-yl-acrylamide; 3-(4-tert-Butyl-phenyl)-N-quinolin-3-yl-propionamide; 3-{4-(1,1-Dimethyl-propyl)-phenyl}-N-quinolin-3-yl-propionamide; 4-(3-Aza-bicyclo{3.3.1}non-3-yl)-N-quinolin-3-yl-benzamide; 4-Azepan-1-yl-N-quinolin-3-yl-benzamide; 6-(3-Aza-bicyclo{3.3.1}non-3-yl)-N-quinolin-3-yl-nicotinamide; 4-tert-Butyl-N-(4-hydroxy-quinolin-3-yl)-benzamide; 3-(4-tert-Butyl-phenyl)-N-(4-hydroxy-quinolin-3-yl)-acrylamide; N-Quinolin-3-yl-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-acrylamide; N-(4-Chloro-quinolin-3-yl)-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-acrylamide; N-(4-Chloro-quinolin-3-yl)-4-(cyclohexyl-methyl-amino)-benzamide; N-(2-Chloro-quinolin-3-yl)-4-(cyclohexyl-methyl-amino)-benzamide; 4-tert-Butyl-N-(2-methoxy-quinolin-3-yl)-benzamide; 4-Azepan-1-yl-N-(4-chloro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(2-chloro-quinolin-3-yl)-benzamide; 4-Azepan-1-yl-N-(2-chloro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(4-chloro-quinolin-3-yl)-benzamide; 3-(1-Cyclohexyl-2,3-dihydro-1H-indol-5-yl)-N-quinolin-3-yl-acrylamide; 1-Cyclohexyl-2,3-dihydro-1H-indole-5-carboxylic acid (2-chloro-quinolin-3-yl)-amide; N-(2-Chloro-quinolin-3-yl)-3-(1-cyclohexyl-2,3-dihydro-1H-indol-5-yl)-acrylamide; 3-(1-Cyclohexyl-1H-indol-5-yl)-N-quinolin-3-yl-acrylamide; N-(4-Chloro-quinolin-3-yl)-3-(1-cyclohexyl-1H-indol-5-yl)-acrylamide; 1-Cyclohexyl-1H-indole-5-carboxylic acid (4-chloro-quinolin-3-yl)-amide; 1-Cyclohexyl-1H-indole-5-carboxylic acid quinolin-3-ylamide; 1-Cyclohexyl-1H-indole-5-carboxylic acid (2-chloro-quinolin-3-yl)-amide; N-(2-Chloro-quinolin-3-yl)-3-(1-cyclohexyl-1H-indol-5-yl)-acrylamide; 4-(Cyclohexyl-methyl-amino)-N-(8-fluoro-quinolin-3-yl)-benzamide; 4-Azocan-1-yl-N-(8-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(8-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(8-trifluoromethyl-quinolin-3-yl)-benzamide; 4-(Cyclohexyl-methyl-amino)-N-(8-trifluoromethyl-quinolin-3-yl)-benzamide; 4-(Cyclohexyl-methyl-amino)-N-(6-fluoro-quinolin-3-yl)-benzamide; 4-Azocan-1-yl-N-(6-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(6-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(7-trifluoromethyl-quinolin-3-yl)-benzamide; 4-Azocan-1-yl-N-(7-trifluoromethyl-quinolin-3-yl)-benzamide; 4-(Cyclohexyl-methyl-amino)-N-(7-trifluoromethyl-quinolin-3-yl)-benzamide; 4-Azocan-1-yl-N-(5-fluoro-quinolin-3-yl)-benzamide; 4-(3-Aza-bicyclo[3.2.2]non-3-yl)-N-(5-fluoro-quinolin-3-yl)-benzamide; 3-Phenyl-propynoic acid quinolin-3-ylamide; trans-2-Phenyl-cyclopropanecarboxylic acid quinolin-3-ylamide; 3-(4-tert-Butyl-phenyl)-propynoic acid quinolin-3-ylamide; and 2-(4-tert-Butyl-phenyl)-cyclopropanecarboxylic acid quinolin-3-ylamide.
- 96. A pharmaceutical composition comprising a compound, salt or solvate according to claim 1 admixed with a pharmaceutically acceptable carrier, excipient or diluent.
- 97. A veterinary composition comprising a compound, salt or solvate according to claim 1 admixed with a veterinarily acceptable carrier, excipient or dilluent.
- 98. A method of treating or preventing a disease or condition in a mammal which disease or condition is affected by the modulation of one or more vanilloid receptors, which method comprises administering to a mammal in need of such treatment or prevention a therapeutically effective amount of a compound, salt or solvate of claim 1.
- 99. A method for preventing or treating a chronic-pain causing disease or condition, an acute-pain causing disease or condition, or a pulmonary dysfunction comprising the step of administering to a mammal in need of such treatment a therapeutically effective amount of a compound, salt or solvate of claim 1.
- 100. A method for preventing or treating a disease or condition, wherein said disease or condition causes inflammatory pain, burning pain, itch urinary incontinence, or chronic obstructive pulmonary disease, said method comprising the step of administering to a mammal in need of such treatment a therapeutically effective amount of a compound, salt or solvate of claim 1.
- 101. A method for preventing or treating a disease or condition selected from the group consisting of osteoarthritis, rheumatoid arthritis, fibromyalgia, migraine, headache, toothache, burn, sunburn, snake bite (in particular, venomous snake bite), spider bite, insect sting, neurogenic bladder, benign prostatic hypertrophy, interstitial cystitis, urinary tract infection, cough asthma, pharyngitis, mucositis, pancreatitis, enteritis, cellulites, peripheral neuropathy, bilateral peripheral neuropathy, diabetic neuropathy, postherpetic neuralgia, trigeminal neuralgia, causalgia, sciatic neuritis, mandibular joint neuralgia, peripheral neuritis, polyneuritis, stump pain, phantom limb pain, bony fractures, post-operative ileus, Irritable Bowel Syndrome, Crohn's Disease, ulcerative colitis, cholecystitis, pancreatitis, postmastectomy pain syndrome, oral neuropathic pain, Charcot's pain, reflex sympathetic dystrophy, Guillain-Barre syndrome, meralgia paresthetica, burning-mouth syndrome, optic neuritis, postfebrile neuritis, migrating neuritis, segmental neuritis, Gombault's neuritis, neuronitis, cervicobrachial neuralgia, cranial neuralgia, geniculate neuralgia, glossopharyngial neuralgia, migrainous neuralgia, idiopathic neuralgia, intercostals neuralgia, mammary neuralgia, Morton's neuralgia, nasociliary neuralgia, occipital neuralgia, red neuralgia, Sluder's neuralgia, splenopalatine neuralgia, supraorbital neuralgia, vidian neuralgia, sinus headache, tension headache, labor, childbirth, intestinal gas, menstrual cramps, cancer, and trauma, said method comprising the step of administering to a mammal in need of such treatment a therapeutically effective amount of a compound, salt or solvate of claim 1.
- 102. The method of claim 101 wherein the disease or condition is ulcerative colitis.
- 103. The method of claim 101 wherein said therapeutically effective amount comprises a dose range of from about 0.001 mg to about 1,000 mg.
- 104. The method of claim 101 wherein said therapeutically effective amount comprises a dose range of from about 0.1 mg to about 500 mg.
- 105. The method of claim 101 wherein said therapeutically effective amount comprises a dose range of from about 1 mg to about 250 mg.
- 106. A kit comprising in one or more containers an amount of the composition of claim 1 effective to treat or prevent a disease or condition selected from the group consisting of osteoarthritis, rheumatoid arthritis, fibromyalgia, migraine, headache, toothache, burn, sunburn, snake bite (in particular, venomous snake bite), spider bite, insect sting, neurogenic bladder, benign prostatic hypertrophy, interstitial cystitis, urinary tract infection, cough asthma, pharyngitis, mucositis, pancreatitis, enteritis, cellulites, peripheral neuropathy, bilateral peripheral neuropathy, diabetic neuropathy, postherpetic neuralgia, trigeminal neuralgia, causalgia, sciatic neuritis, mandibular joint neuralgia, peripheral neuritis, polyneuritis, stump pain, phantom limb pain, bony fractures, post-operative ileus, Irritable Bowel Syndrome, Crohn's Disease, ulcerative colitis, cholecystitis, pancreatitis, postmastectomy pain syndrome, oral neuropathic pain, Charcot's pain, reflex sympathetic dystrophy, Guillain-Barre syndrome, meralgia paresthetica, burning-mouth syndrome, optic neuritis, postfebrile neuritis, migrating neuritis, segmental neuritis, Gombault's neuritis, neuronitis, cervicobrachial neuralgia, cranial neuralgia, geniculate neuralgia, glossopharyngial neuralgia, migrainous neuralgia, idiopathic neuralgia, intercostals neuralgia, mammary neuralgia, Morton's neuralgia, nasociliary neuralgia, occipital neuralgia, red neuralgia, Sluder's neuralgia, splenopalatine neuralgia, supraorbital neuralgia, vidian neuralgia, sinus headache, tension headache, labor, childbirth, intestinal gas, menstrual cramps, cancer, and trauma.
- 107. A pharmaceutical composition comprising a compound, salt or solvate according to claim 17 admixed with a pharmaceutically acceptable carrier, excipient or diluent.
- 108. A veterinary composition comprising a compound, salt or solvate according to claim 17 admixed with a veterinarily acceptable carrier, excipient or dilluent.
- 109. A method for preventing or treating a disease or condition selected from the group consisting of osteoarthritis, rheumatoid arthritis, fibromyalgia, migraine, headache, toothache, burn, sunburn, snake bite (in particular, venomous snake bite), spider bite, insect sting, neurogenic bladder, benign prostatic hypertrophy, interstitial cystitis, urinary tract infection, cough asthma, pharyngitis, mucositis, pancreatitis, enteritis, cellulites, peripheral neuropathy, bilateral peripheral neuropathy, diabetic neuropathy, postherpetic neuralgia, trigeminal neuralgia, causalgia, sciatic neuritis, mandibular joint neuralgia, peripheral neuritis, polyneuritis, stump pain, phantom limb pain, bony fractures, post-operative ileus, Irritable Bowel Syndrome, Crohn's Disease, ulcerative colitis, cholecystitis, pancreatitis, postmastectomy pain syndrome, oral neuropathic pain, Charcot's pain, reflex sympathetic dystrophy, Guillain-Barre syndrome, meralgia paresthetica, burning-mouth syndrome, optic neuritis, postfebrile neuritis, migrating neuritis, segmental neuritis, Gombault's neuritis, neuronitis, cervicobrachial neuralgia, cranial neuralgia, geniculate neuralgia, glossopharyngial neuralgia, migrainous neuralgia, idiopathic neuralgia, intercostals neuralgia, mammary neuralgia, Morton's neuralgia, nasociliary neuralgia, occipital neuralgia, red neuralgia, Sluder's neuralgia, splenopalatine neuralgia, supraorbital neuralgia, vidian neuralgia, sinus headache, tension headache, labor, childbirth, intestinal gas, menstrual cramps, cancer, and trauma, said method comprising the step of administering to a mammal in need of such treatment a therapeutically effective amount of a compound, salt or solvate of claim 17.
- 110. The method of claim 109 wherein the disease or condition is ulcerative colitis.
- 111. The method of claim 109 wherein said therapeutically effective amount comprises a dose range of from about 0.001 mg to about 1,000 mg.
- 112. The method of claim 109 wherein said therapeutically effective amount comprises a dose range of from about 0.1 mg to about 500 mg.
- 113. The method of claim 109 wherein said therapeutically effective amount comprises a dose range of from about 1 mg to about 250 mg.
- 114. A kit comprising in one or more containers an amount of the composition of claim 17 effective to treat or prevent a disease or condition selected from the group consisting of osteoarthritis, rheumatoid arthritis, fibromyalgia, migraine, headache, toothache, burn, sunburn, snake bite (in particular, venomous snake bite), spider bite, insect sting, neurogenic bladder, benign prostatic hypertrophy, interstitial cystitis, urinary tract infection, cough asthma, pharyngitis, mucositis, pancreatitis, enteritis, cellulites, peripheral neuropathy, bilateral peripheral neuropathy, diabetic neuropathy, postherpetic neuralgia, trigeminal neuralgia, causalgia, sciatic neuritis, mandibular joint neuralgia, peripheral neuritis, polyneuritis, stump pain, phantom limb pain, bony fractures, post-operative ileus, Irritable Bowel Syndrome, Crohn's Disease, ulcerative colitis, cholecystitis, pancreatitis, postmastectomy pain syndrome, oral neuropathic pain, Charcot's pain, reflex sympathetic dystrophy, Guillain-Barre syndrome, meralgia paresthetica, burning-mouth syndrome, optic neuritis, postfebrile neuritis, migrating neuritis, segmental neuritis, Gombault's neuritis, neuronitis, cervicobrachial neuralgia, cranial neuralgia, geniculate neuralgia, glossopharyngial neuralgia, migrainous neuralgia, idiopathic neuralgia, intercostals neuralgia, mammary neuralgia, Morton's neuralgia, nasociliary neuralgia, occipital neuralgia, red neuralgia, Sluder's neuralgia, splenopalatine neuralgia, supraorbital neuralgia, vidian neuralgia, sinus headache, tension headache, labor, childbirth, intestinal gas, menstrual cramps, cancer, and trauma.
- 115. A pharmaceutical composition comprising a compound, salt or solvate according to claim 31 admixed with a pharmaceutically acceptable carrier, excipient or diluent.
- 116. A veterinary composition comprising a compound, salt or solvate according to claim 31 admixed with a veterinarily acceptable carrier, excipient or dilluent.
- 117. A method for preventing or treating a disease or condition selected from the group consisting of osteoarthritis, rheumatoid arthritis, fibromyalgia, migraine, headache, toothache, burn, sunburn, snake bite (in particular, venomous snake bite), spider bite, insect sting, neurogenic bladder, benign prostatic hypertrophy, interstitial cystitis, urinary tract infection, cough asthma, pharyngitis, mucositis, pancreatitis, enteritis, cellulites, peripheral neuropathy, bilateral peripheral neuropathy, diabetic neuropathy, postherpetic neuralgia, trigeminal neuralgia, causalgia, sciatic neuritis, mandibular joint neuralgia, peripheral neuritis, polyneuritis, stump pain, phantom limb pain, bony fractures, post-operative ileus, Irritable Bowel Syndrome, Crohn's Disease, ulcerative colitis, cholecystitis, pancreatitis, postmastectomy pain syndrome, oral neuropathic pain, Charcot's pain, reflex sympathetic dystrophy, Guillain-Barre syndrome, meralgia paresthetica, burning-mouth syndrome, optic neuritis, postfebrile neuritis, migrating neuritis, segmental neuritis, Gombault's neuritis, neuronitis, cervicobrachial neuralgia, cranial neuralgia, geniculate neuralgia, glossopharyngial neuralgia, migrainous neuralgia, idiopathic neuralgia, intercostals neuralgia, mammary neuralgia, Morton's neuralgia, nasociliary neuralgia, occipital neuralgia, red neuralgia, Sluder's neuralgia, splenopalatine neuralgia, supraorbital neuralgia, vidian neuralgia, sinus headache, tension headache, labor, childbirth, intestinal gas, menstrual cramps, cancer, and trauma, said method comprising the step of administering to a mammal in need of such treatment a therapeutically effective amount of a compound, salt or solvate of claim 31.
- 118. The method of claim 117 wherein the disease or condition is ulcerative colitis.
- 119. The method of claim 117 wherein said therapeutically effective amount comprises a dose range of from about 0.001 mg to about 1,000 mg.
- 120. The method of claim 117 wherein said therapeutically effective amount comprises a dose range of from about 0.1 mg to about 500 mg.
- 121. The method of claim 117 wherein said therapeutically effective amount comprises a dose range of from about 1 mg to about 250 mg.
- 122. A kit comprising in one or more containers an amount of the composition of claim 31 effective to treat or prevent a disease or condition selected from the group consisting of osteoarthritis, rheumatoid arthritis, fibromyalgia, migraine, headache, toothache, burn, sunburn, snake bite (in particular, venomous snake bite), spider bite, insect sting, neurogenic bladder, benign prostatic hypertrophy, interstitial cystitis, urinary tract infection, cough asthma, pharyngitis, mucositis, pancreatitis, enteritis, cellulites, peripheral neuropathy, bilateral peripheral neuropathy, diabetic neuropathy, postherpetic neuralgia, trigeminal neuralgia, causalgia, sciatic neuritis, mandibular joint neuralgia, peripheral neuritis, polyneuritis, stump pain, phantom limb pain, bony fractures, post-operative ileus, Irritable Bowel Syndrome, Crohn's Disease, ulcerative colitis, cholecystitis, pancreatitis, postmastectomy pain syndrome, oral neuropathic pain, Charcot's pain, reflex sympathetic dystrophy, Guillain-Barre syndrome, meralgia paresthetica, burning-mouth syndrome, optic neuritis, postfebrile neuritis, migrating neuritis, segmental neuritis, Gombault's neuritis, neuronitis, cervicobrachial neuralgia, cranial neuralgia, geniculate neuralgia, glossopharyngial neuralgia, migrainous neuralgia, idiopathic neuralgia, intercostals neuralgia, mammary neuralgia, Morton's neuralgia, nasociliary neuralgia, occipital neuralgia, red neuralgia, Sluder's neuralgia, splenopalatine neuralgia, supraorbital neuralgia, vidian neuralgia, sinus headache, tension headache, labor, childbirth, intestinal gas, menstrual cramps, cancer, and trauma.
- 123. A pharmaceutical composition comprising a compound, salt or solvate according to claim 61 admixed with a pharmaceutically acceptable carrier, excipient or diluent.
- 124. A veterinary composition comprising a compound, salt or solvate according to claim 61 admixed with a veterinarily acceptable carrier, excipient or dilluent.
- 125. A method for preventing or treating a disease or condition selected from the group consisting of osteoarthritis, rheumatoid arthritis, fibromyalgia, migraine, headache, toothache, burn, sunburn, snake bite (in particular, venomous snake bite), spider bite, insect sting, neurogenic bladder, benign prostatic hypertrophy, interstitial cystitis, urinary tract infection, cough asthma, pharyngitis, mucositis, pancreatitis, enteritis, cellulites, peripheral neuropathy, bilateral peripheral neuropathy, diabetic neuropathy, postherpetic neuralgia, trigeminal neuralgia, causalgia, sciatic neuritis, mandibular joint neuralgia, peripheral neuritis, polyneuritis, stump pain, phantom limb pain, bony fractures, post-operative ileus, Irritable Bowel Syndrome, Crohn's Disease, ulcerative colitis, cholecystitis, pancreatitis, postmastectomy pain syndrome, oral neuropathic pain, Charcot's pain, reflex sympathetic dystrophy, Guillain-Barre syndrome, meralgia paresthetica, burning-mouth syndrome, optic neuritis, postfebrile neuritis, migrating neuritis, segmental neuritis, Gombault's neuritis, neuronitis, cervicobrachial neuralgia, cranial neuralgia, geniculate neuralgia, glossopharyngial neuralgia, migrainous neuralgia, idiopathic neuralgia, intercostals neuralgia, mammary neuralgia, Morton's neuralgia, nasociliary neuralgia, occipital neuralgia, red neuralgia, Sluder's neuralgia, splenopalatine neuralgia, supraorbital neuralgia, vidian neuralgia, sinus headache, tension headache, labor, childbirth, intestinal gas, menstrual cramps, cancer, and trauma, said method comprising the step of administering to a mammal in need of such treatment a therapeutically effective amount of a compound, salt or solvate of claim 61.
- 126. The method of claim 125 wherein the disease or condition is ulcerative colitis.
- 127. The method of claim 125 wherein said therapeutically effective amount comprises a dose range of from about 0.001 mg to about 1,000 mg.
- 128. The method of claim 125 wherein said therapeutically effective amount comprises a dose range of from about 0.1 mg to about 500 mg.
- 129. The method of claim 125 wherein said therapeutically effective amount comprises a dose range of from about 1 mg to about 250 mg.
- 130. A kit comprising in one or more containers an amount of the composition of claim 61 effective to treat or prevent a disease or condition selected from the group consisting of osteoarthritis, rheumatoid arthritis, fibromyalgia, migraine, headache, toothache, burn, sunburn, snake bite (in particular, venomous snake bite), spider bite, insect sting, neurogenic bladder, benign prostatic hypertrophy, interstitial cystitis, urinary tract infection, cough asthma, pharyngitis, mucositis, pancreatitis, enteritis, cellulites, peripheral neuropathy, bilateral peripheral neuropathy, diabetic neuropathy, postherpetic neuralgia, trigeminal neuralgia, causalgia, sciatic neuritis, mandibular joint neuralgia, peripheral neuritis, polyneuritis, stump pain, phantom limb pain, bony fractures, post-operative ileus, Irritable Bowel Syndrome, Crohn's Disease, ulcerative colitis, cholecystitis, pancreatitis, postmastectomy pain syndrome, oral neuropathic pain, Charcot's pain, reflex sympathetic dystrophy, Guillain-Barre syndrome, meralgia paresthetica, burning-mouth syndrome, optic neuritis, postfebrile neuritis, migrating neuritis, segmental neuritis, Gombault's neuritis, neuronitis, cervicobrachial neuralgia, cranial neuralgia, geniculate neuralgia, glossopharyngial neuralgia, migrainous neuralgia, idiopathic neuralgia, intercostals neuralgia, mammary neuralgia, Morton's neuralgia, nasociliary neuralgia, occipital neuralgia, red neuralgia, Sluder's neuralgia, splenopalatine neuralgia, supraorbital neuralgia, vidian neuralgia, sinus headache, tension headache, labor, childbirth, intestinal gas, menstrual cramps, cancer, and trauma.
- 131. A pharmaceutical composition comprising a compound, salt or solvate according to claim 78 admixed with a pharmaceutically acceptable carrier, excipient or diluent.
- 132. A veterinary composition comprising a compound, salt or solvate according to claim 78 admixed with a veterinarily acceptable carrier, excipient or dilluent.
- 133. A method for preventing or treating a disease or condition selected from the group consisting of osteoarthritis, rheumatoid arthritis, fibromyalgia, migraine, headache, toothache, burn, sunburn, snake bite (in particular, venomous snake bite), spider bite, insect sting, neurogenic bladder, benign prostatic hypertrophy, interstitial cystitis, urinary tract infection, cough asthma, pharyngitis, mucositis, pancreatitis, enteritis, cellulites, peripheral neuropathy, bilateral peripheral neuropathy, diabetic neuropathy, postherpetic neuralgia, trigeminal neuralgia, causalgia, sciatic neuritis, mandibular joint neuralgia, peripheral neuritis, polyneuritis, stump pain, phantom limb pain, bony fractures, post-operative ileus, Irritable Bowel Syndrome, Crohn's Disease, ulcerative colitis, cholecystitis, pancreatitis, postmastectomy pain syndrome, oral neuropathic pain, Charcot's pain, reflex sympathetic dystrophy, Guillain-Barre syndrome, meralgia paresthetica, burning-mouth syndrome, optic neuritis, postfebrile neuritis, migrating neuritis, segmental neuritis, Gombault's neuritis, neuronitis, cervicobrachial neuralgia, cranial neuralgia, geniculate neuralgia, glossopharyngial neuralgia, migrainous neuralgia, idiopathic neuralgia, intercostals neuralgia, mammary neuralgia, Morton's neuralgia, nasociliary neuralgia, occipital neuralgia, red neuralgia, Sluder's neuralgia, splenopalatine neuralgia, supraorbital neuralgia, vidian neuralgia, sinus headache, tension headache, labor, childbirth, intestinal gas, menstrual cramps, cancer, and trauma, said method comprising the step of administering to a mammal in need of such treatment a therapeutically effective amount of a compound, salt or solvate of claim 78.
- 134. The method of claim 133 wherein the disease or condition is ulcerative colitis.
- 135. The method of claim 133 wherein said therapeutically effective amount comprises a dose range of from about 0.001 mg to about 1,000 mg.
- 136. The method of claim 133 wherein said therapeutically effective amount comprises a dose range of from about 0.1 mg to about 500 mg.
- 137. The method of claim 133 wherein said therapeutically effective amount comprises a dose range of from about 1 mg to about 250 mg.
- 138. A kit comprising in one or more containers an amount of the composition of claim 133 effective to treat or prevent a disease or condition selected from the group consisting of osteoarthritis, rheumatoid arthritis, fibromyalgia, migraine, headache, toothache, burn, sunburn, snake bite (in particular, venomous snake bite), spider bite, insect sting, neurogenic bladder, benign prostatic hypertrophy, interstitial cystitis, urinary tract infection, cough asthma, pharyngitis, mucositis, pancreatitis, enteritis, cellulites, peripheral neuropathy, bilateral peripheral neuropathy, diabetic neuropathy, postherpetic neuralgia, trigeminal neuralgia, causalgia, sciatic neuritis, mandibular joint neuralgia, peripheral neuritis, polyneuritis, stump pain, phantom limb pain, bony fractures, post-operative ileus, Irritable Bowel Syndrome, Crohn's Disease, ulcerative colitis, cholecystitis, pancreatitis, postmastectomy pain syndrome, oral neuropathic pain, Charcot's pain, reflex sympathetic dystrophy, Guillain-Barre syndrome, meralgia paresthetica, burning-mouth syndrome, optic neuritis, postfebrile neuritis, migrating neuritis, segmental neuritis, Gombault's neuritis, neuronitis, cervicobrachial neuralgia, cranial neuralgia, geniculate neuralgia, glossopharyngial neuralgia, migrainous neuralgia, idiopathic neuralgia, intercostals neuralgia, mammary neuralgia, Morton's neuralgia, nasociliary neuralgia, occipital neuralgia, red neuralgia, Sluder's neuralgia, splenopalatine neuralgia, supraorbital neuralgia, vidian neuralgia, sinus headache, tension headache, labor, childbirth, intestinal gas, menstrual cramps, cancer, and trauma.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application claims priority to U.S. Provisional Patent Application No. 60/444,442, filed Feb. 3, 2003, which is hereby fully incorporated herein by reference.
Provisional Applications (1)
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Number |
Date |
Country |
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60444442 |
Feb 2003 |
US |