Claims
- 1. A compound of the formula: ##STR5## and pharmaceutically acceptable salts thereof wherein Ar is phenyl;
- Y is O or CR.sub.3 R.sub.4 ;
- X is O or CR.sub.3 R.sub.4 ;
- Z and Z.sub.1 are independently a chemical bond or an alkylene chain having up to 6 carbon atoms in the principal chain and up to a total of 10 carbon atoms;
- Z.sub.2 is a chemical bond or an alkylene chain or a mono-substituted alkylene chain containing up to 6 carbon atoms in the principal chain and up to a total of 10 carbon atoms and the substituents are hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, or C.sub.1 -C.sub.5 carbalkoxy;
- R is quinolyl;
- R.sub.1 is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.5 cycloalkyl, phenyl or quinolyl;
- R.sub.2, R.sub.3 and R.sub.4 are each hydrogen or C.sub.1 -C.sub.5 alkyl;
- and n is an integer from 0-2, with the proviso that when n=0,
- R.sub.1 is quinolyl.
- 2. The compound according to claim 1 wherein Y is O or CR.sub.3 R.sub.4.
- 3. The compound according to claim 1 wherein X is O or CR.sub.3 R.sub.4.
- 4. The compound according to claim 1 wherein Z and Z.sub.1 are each a chemical bond or an alkylene chain containing up to 3 carbon atoms in the principal chain.
- 5. The compound according to claim 1 wherein Z.sub.2 is an alkylene chain containing up to 5 carbon atoms in the principal chain.
- 6. A compound of the formula: ##STR6## and pharmaceutically acceptable salts thereof; wherein R is quinolyl;
- R.sub.1 is hydrogen, C.sub.1 -C.sub.5 alkyl, or phenyl;
- Z and Z.sub.1 are independently a chemical bond or an alkylene chain having up to 6 carbon atoms in the principal chain and up to a total of 10 carbon atoms;
- Z.sub.2 is a chemical bond or an alkylene chain or a mono-substituted alkylene chain containing up to 6 carbon atoms in the principal chain and up to a total of 10 carbon atoms and the substituents are hydrogen, C.sub.1 -C.sub.5 alkyl, or carboxy;
- X is independently O or CR.sub.3 R.sub.4 ;
- R.sub.3 is independently hydrogen or C.sub.1 -C.sub.5 alkyl;
- n is 0, 1 or 2; and
- R.sub.5 is hydrogen.
- 7. The compound according to claim 1 which is .alpha.-(3-(2-quinolylmethoxy)phenyl)-N-(2-phenethyl)-acetohydroxamate.
- 8. The compound according to claim 1 which is N-hydroxy-N-methyl-3-((2-quinolyl)methoxy)phenyl acetamide.
- 9. The compound according to claim 1 which is N-hydroxy-N-methyl-4-((2-quinolyl)methoxy)phenyl acetamide.
- 10. A compound having the formula: ##STR7## and pharmaceutically acceptable salts thereof, wherein R is quinolyl;
- Z is a chemical bond or C.sub.1-3 alkylene;
- X is O or CR.sub.3 R.sub.4 ;
- Z.sub.2 is a chemical bond or C.sub.1-3 alkylene;
- R.sub.1 is C.sub.1-3 alkyl, phenyl, carboxy, or phenyl substituted with methoxy or chlorine;
- each R.sub.3 is independently hydrogen or C.sub.1-3 alkyl; and
- R.sub.4 is hydrogen or C.sub.1-3 alkyl.
- 11. A therapeutic composition comprising a compound according to claim 1 and a pharmaceutical carrier therefor.
- 12. A method of treating hypersensitive disease, inflammatory conditions or allergic responses in a mammal comprising the administration to said mammal of a therapeutically effective amount of a compound according to claim 1.
Parent Case Info
This is a continuation-in-part of U.S. patent application Ser. No. 719,199, which was filed on Apr. 3, 1985, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3481970 |
Levy |
Dec 1969 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
1102867 |
Feb 1968 |
GBX |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
719199 |
Apr 1985 |
|