Claims
- 1. A quinolone compound of the formula: ##STR18## wherein R.sup.1 is H, R.sup.2 is ##STR19## and R.sup.3 is CH.sub.3 ; R.sup.1 is CH.sub.3, R.sup.2 is ##STR20## and R.sup.3 is CH.sub.3 ; R.sup.1 is CH.sub.2 SCH.sub.3, R.sup.2 is ##STR21## and R.sup.3 is CH.sub.3 ; R.sup.1 is CH.sub.3, R.sup.2 is ##STR22## and R.sup.3 is CH.sub.3 ; R.sup.1 is H, R.sup.2 is ##STR23## and R.sup.3 is H; R.sup.1 is CH.sub.3, R.sup.2 is ##STR24## and R.sup.3 is H; R.sup.1 is CH.sub.3, R.sup.2 is ##STR25## and R.sup.3 is H; or R.sup.1 is CH.sub.3, R.sup.2 is ##STR26## and R.sup.3 is H.
- 2. A quinolone compound according to claim 1, wherein
- R.sup.1 is H, R.sup.2 is ##STR27## and R.sup.3 is CH.sub.3 ; R.sup.1 is CH.sub.3, R.sup.2 is ##STR28## and R.sup.3 is CH.sub.3 ; or R.sup.1 is CH.sub.3, R.sup.2 is ##STR29## and R.sup.3 is CH.sub.3.
- 3. A quinolone compound according to claim 2, wherein R.sup.1 is H, R.sup.2 is: ##STR30## and R.sup.3 is CH.sub.3.
- 4. A process for producing quinolone compounds according to claim 1, which comprises cultivating a microorganism having the identifying characteristics of Amycolata sp. FERM BP-4785, or a mutant or recombinant form thereof.
- 5. A process according to claim 4, which further comprises the subsequent step of isolating said quinolone compounds from the fermentation broth.
- 6. A pharmaceutical composition for use in the treatment of Helicobacter pylori-induced disorders, diseases or adverse conditions caused thereby, which comprises a compound according to claim 1 and a pharmaceutically-acceptable carrier.
Priority Claims (1)
Number |
Date |
Country |
Kind |
PCT/IB95/00812 |
Sep 1995 |
WOX |
|
Parent Case Info
This application is a 371 of PCT/IB96/00670, filed Jul. 11, 1996.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/IB96/00670 |
7/11/1996 |
|
|
4/24/1998 |
4/24/1998 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO97/12868 |
4/10/1997 |
|
|
Non-Patent Literature Citations (4)
Entry |
Chemical Abstracts 109:92736, coppola, 1988. |
Chemical Abstracts 108:142529, Huang, 1987. |
Marpat 118:22154, Clemence, 1992. |
Marpat 118:22153, Clemence, 1992. |