Claims
- 1. A composition comprising an effective amount of a substituted quinoxaline represented by the formula ##STR4## where R is hydrogen or lower alkyl of 1 to 5 carbon atoms, and a pharmaceutically acceptable carrier.
- 2. The composition of claim 1 in suitable form for oral administration and where R is hydrogen.
- 3. The composition of claim 1 in suitable form for oral administration and where R is methyl.
- 4. A method of combatting the growth of cholera-producing organism in water by incorporating in the water an effective amount of a substituted quinoxaline represented by the formula ##STR5## where R is hydrogen or lower alkyl of 1 to 5 carbon atoms.
- 5. The method of claim 4 wherein the cholera-producing organism is a vibrio organism.
- 6. The method of claim 5 wherein the amount of quinoxaline incorporated in water is from about 10 to about 100 .mu.g/ml.
- 7. The method of claim 5 wherein the vibrio organism is a vibrio cholerae organism.
- 8. The method of claim 7 wherein R is hydrogen.
- 9. The method of claim 7 wherein R is methyl.
- 10. A method of claim 7 wherein the amount of quinoxaline compound incorporated in water is from about 30 to about 100 .mu.g/ml.
- 11. A method of combatting cholera by administration to an individual exposed to a cholera-producing organism an effective amount of a substituted quinoxaline represented by the formula ##STR6## wherein R is hydrogen or lower alkyl of 1 to 5 carbon atoms.
- 12. The method of claim 11 wherein the cholera-producing organism is a vibrio organism and the quinoxaline is prophylactically administered.
- 13. The method of claim 12 wherein the vibrio organism is a vibrio cholerae organism and the quinoxaline is orally administered.
- 14. The method of claim 13 wherein R is hydrogen.
- 15. The method of claim 13 wherein R is methyl.
- 16. The method of claim 14 wherein the prophylactic administration includes the administration of from about 0.3 to 5 g per day of the quinoxaline compound to a human exposed to the vibrio cholerae organism.
- 17. The method of claim 16 wherein the prophylactic administration is conducted for about 3 to 5 days.
- 18. The method of claim 15 wherein the prophylactic administration includes the administration of about 0.3 to 5 g per day of the quinoxaline compound to a human exposed to the vibrio cholerae organism.
- 19. The method of claim 18 wherein the prophylactic administration is conducted for about 3 to 5 days.
- 20. A quinoxaline compound represented by the formula ##STR7## where R is hydrogen or lower alkyl of 1 to 5 carbon atoms.
- 21. The compound of claim 1 where R is hydrogen.
- 22. The compound of claim 1 where R is methyl.
- 23. A process for preparing quinoxaline compounds which comprises reacting a quinoxaline -di-N-oxide-2-carboxyaldehyde dimethylacetal and a compound represented by the formula ##STR8## wherein R is hydrogen or lower alkyl of 1 to 5 carbon atoms, under reaction conditions sufficient to produce a quinoxaline compound represented by the formula ##STR9## where R has the same meaning as defined above.
- 24. The process of claim 23 wherein the reaction is catalyzed and is conducted at temperatures from about 0.degree. C. to 80.degree. C. in a solvent.
- 25. The process of claim 24 wherein the reactants are reacted in an approximately 1:1 mole ratio and the catalyst is a strong mineral acid.
- 26. The process of claim 25 wherein the solvent is a lower alkanoic acid.
- 27. The process of claim 23 wherein R is hydrogen.
- 28. The process of claim 23 wherein R is methyl.
- 29. The process of claim 26 wherein R is hydrogen or methyl.
Parent Case Info
This application is a continuation-in-part of application Ser. No. 672,123, filed March 31, 1976, now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3671521 |
Abuel-Haj |
Jun 1972 |
|
3965327 |
Cresswell et al. |
May 1976 |
|
3969346 |
Koller et al. |
Jul 1976 |
|
Non-Patent Literature Citations (1)
Entry |
Chem. Abs. General Subj. Index, vol. 82, 1-6, 1975, pp. 302GS & 303GS. |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
672123 |
Mar 1976 |
|