Claims
- 1. A radioprotective agent 3-(3"-aminoalkyl)-2-arylthiazolidine or a pharmacologically acceptable salt thereof having the formula: ##STR4## wherein R is a NH.sub.2 R' or XNHR' radical in which R' is a C.sub.2 to C.sub.4 alkyl group and X is a C.sub.1 to C.sub.3 alkyl group and Ar is an aromatic group derived from the corresponding aromatic aldehyde; or a pharmacologically acceptable salt thereof.
- 2. The agent of claim 1 wherein said aromatic aldehyde is selected from: ##STR5## wherein R" is a halogen or nitro group, C.sub.1 to C.sub.3 alkoxy, or C.sub.1 to C.sub.3 alkyl radical, and Y is a C.sub.1 -C.sub.3 alkylene radical.
- 3. The radio protective agent of claim 1 or 2 wherein said radioprotective agent is selected from 2-(4'-nitrophenyl)-3-(3"-aminopropyl)thiazolidine, 2-(4'-methoxyphenyl)-3-(3"-aminopropyl)thiazolidine, 2-(3',4'-dimethoxyphenyl)-3-(3"-aminopropyl)thiazolidine, 2-[3',4'-(methylenedioxy)phenyl]-3-(3"-aminopropyl)thiazolidine, 2-(3'-methoxyphenyl)-3-(3"-aminopropyl)thiazolidine, or pharmacologically acceptable salts thereof.
- 4. The method of making a radioprotective agent comprising reacting a substituted phosphorothioic acid of the formula:
- R--NCH.sub.2 CH.sub.2 SPO.sub.3 H.sub.2
- wherein R is a NH.sub.2 R' or XNHR' radical in which R' is a C.sub.2 to C.sub.4 alkyl group and X is a C.sub.1 to C.sub.3 alkyl group, with an aromatic aldehyde in an alcoholic or dimethylsulfoxide medium at a time and for a temperature sufficient to form a 3-(3"-aminoalkyl)-2-arylthiazolidine having the formula: ##STR6## wherein R is a NH.sub.2 R' or XNHR' radical in which R' is a C.sub.2 to C.sub.4 alkyl group and X is a C.sub.1 to C.sub.3 alkyl group and Ar is an aromatic group derived from the corresponding aromatic aldehyde.
- 5. The method of claim 4 wherein said arylthiazolidine is reacted with an anhydrous acid to form a pharmacologically acceptable salt.
- 6. The method of claim 4 or 5 wherein said aryl aldehyde is selected from ##STR7## wherein R" is a halogen or nitro group or a C.sub.1 to C.sub.3 alkoxy, or alkyl radical and Y is a C.sub.1 -C.sub.3 alkylene radical.
- 7. The method of claim 4 or 5 wherein said substituted phosphorothioic acid is S-(2-(3-aminopropylamino)ethyl phosphorothioate and said aryl aldehyde is selected from ##STR8## wherein R" is a halogen or nitro group or a C.sub.1 to C.sub.3 alkoxy, or alkyl radical and Y is a C.sub.1 -C.sub.3 alkylene radical.
- 8. The method of claim 5 wherein said arylthiazolidine is placed in solution in ether prior to being reacted with said anhydrous acid.
- 9. The method of protecting an animal against the effects of radioactivity comprising administering to said animal in an amount effective to protect against the effects of radioactivity, a radioprotective agent comprising a 3-(3"-aminoalkyl)-2-arylthiazolidine or a pharmacologically acceptable salt thereof having the formula: ##STR9## wherein R is a NH.sub.2 R' or HNHR' radical in which R' is a C.sub.2 to C.sub.4 alkyl group and X is a C.sub.1 to C.sub.3 alkyl group and Ar is an aromatic group derived from the corresponding aromatic aldehyde.
- 10. The method of claim 9 wherein said aromatic aldehyde is selected from ##STR10## wherein R" is a halogen or nitro group, C.sub.1 to C.sub.3 alkoxy, or C.sub.1 to C.sub.3 alkyl radical, and Y is a C.sub.1 -C.sub.3 alkylene radical.
- 11. The method of claim 9 or 10 wherein said arylthiazolidine is selected from 2-(4'-nitrophenyl)3-(3"-aminopropyl)thiazolidine, 2-(4'-methoxyphenyl)-3-(3'-aminopropyl)thiazolidine, 2-(3',4'-dimethoxyphenyl)-3-(3"-aminopropyl)thiazolidine, 2-[3',4'(methylenedioxy)phenyl]-3-(3"-aminopropyl)thiazolidine, 2-(3'-methoxyphenyl)-3-(3"-aminopropyl)thiazolidine, or pharmacologically acceptable salts thereof.
BACKGROUND OF THE INVENTION
This invention was made under United States Government Contract No. DAMD-17-82-C-2075 and the United States Government has a nonexclusive, nontransferable, irrevocable, paid-up license to practice, or have practiced for or on behalf of the United States, this invention throughout the world.