Claims
- 1. A method of increasing the triglyceride content of the colostrum or milk of a lactating sow which comprises administering to said sow, at a time from about 3 days before farrowing to about 10 days after farrowing, a milk-fat-increasing amount of a compound of the formula ##STR7## wherein: R is hydrogen, hydroxy, methoxy or amino;
- R.sup.1 is hydrogen, cyano or NR.sup.3 R.sup.4 ;
- R.sup.3 is hydrogen or methyl;
- R.sup.4 is hydrogen, methyl, formyl or --COCH.sup.2 NHCHO;
- R.sup.2 is C.sub.2 -C.sub.4 alkyl or ##STR8## R.sup.5 is hydrogen or methyl; n is 1 or 2;
- R.sup.6 is morpholino or ##STR9## R.sup.7 is hydrogen, hydroxy, fluoro, nitro, carbamoyl or methoxy; provided that:
- R and R.sup.7 are not both hydrogen;
- R.sup.7 is not hydroxy when R is hydrogen;
- R is hydrogen or amino when R.sup.1 is cyano;
- R is hydrogen, hydroxy or methoxy when R.sup.1 is hydrogen;
- R.sup.2 is not C.sub.2 -C.sub.4 alkyl when R.sup.1 is hydrogen;
- R is not methoxy when R.sup.2 is alkyl, when R.sup.6 is morpholino, or when R.sup.7 is hydrogen, fluoro, nitro or methoxy;
- or a physiologically acceptable acid addition salt thereof.
- 2. A method of claim 1 wherein the administration is begun on the day of farrowing and continues for from about 3 to about 7 days after farrowing.
- 3. A method of claim 2 wherein the administration is oral at a dosage rate from about 0.05 to about 2 mg/kg/day.
- 4. A method of claim 2 wherein the administration is percutaneous at a dosage rate from about 0.005 to about 0.5 mg/kg/day.
- 5. A method of claim 3 wherein the dosage rate is from about 0.25 to about 1 mg/kg/day.
- 6. A method of claim 4 wherein the dosage rate is from about 0.05 to about 0.2 mg/kg/day.
- 7. A method of claim 1 wherein the compound is a compound wherein R is hydrogen or hydroxy.
- 8. A method of claim 7 wherein R.sup.7 is hydroxy or carbamoyl.
- 9. A method of claim 1 wherein the compound is 1-(4-hydroxyphenyl)-2-[3-(4-hydroxyphenyl)-1-methylpropylamino]ethanol or a physiologically-acceptable acid addition salt thereof.
- 10. A method of claim 3 wherein the compound is 1-(4-hydroxyphenyl)-2-[3-(4-hydroxyphenyl)-1-methylpropylamino]ethanol or a physiologically-acceptable acid addition salt thereof.
- 11. A method of claim 4 wherein the compound is 1-(4-hydroxyphenyl)-2-[3-(4-hydroxyphenyl)-1-methylpropylamino]ethanol or a physiologically-acceptable acid addition salt thereof.
- 12. A method of claim 1 wherein the compound is 2-[3-(4-aminocarbonylphenyl)-1-methylpropylamino]-1-phenylethanol or a physiologically-acceptable acid addition salt thereof.
- 13. A method of claim 3 wherein the compound is 2-[3-(4-aminocarbonylphenyl)-1-methylpropylamino]-1-phenylethanol or a physiologically-acceptable acid addition salt thereof.
- 14. A method of claim 4 wherein the compound is 2-[3-(4-aminocarbonylphenyl)-1-methylpropylamino]-1-phenylethanol or a physiologically-acceptable acid addition salt thereof.
- 15. A method of claim 1 wherein the compound is 1-(4-amino-3-cyanophenyl)-2-isopropylaminoethanol or a physiologically-acceptable acid addition salt thereof.
- 16. A method of claim 3 wherein the compound is 1-(4-amino-3-cyanophenyl)-2-isopropylaminoethanol or a physiologically-acceptable acid addition salt thereof.
- 17. A method of claim 4 wherein the compound is 1-(4-amino-3-cyanophenyl)-2-isopropylaminoethanol or a physiologically-acceptable acid addition salt thereof.
- 18. A method of claim 1 wherein the compound is 1-(3-formamido-4-hydroxyphenyl)-2-[2-(4-methoxyphenyl)-1-methylethylamino]ethanol or a physiologically-acceptable acid addition salt thereof.
- 19. A method of claim 1 wherein the compound is 1-(3-formamido-4-hydroxyphenyl)-2-(1-methyl-3-morpholinopropylamino)ethanol or a physiologically-acceptable acid addition salt thereof.
- 20. A method of claim 1 wherein the compound is 2-t-butylamino-1-(4-hydroxy-3-methylaminophenyl)ethanol or a physiologically-acceptable acid addition salt thereof.
CROSS-REFERENCE
This application is a continuation-in-part of copending application Ser. No. 901,908, filed Aug. 28, 1986, now abandoned which is a continuation-in-part of then copending application Ser. No. 802,541, filed Nov. 27, 1985, now abandoned.
US Referenced Citations (5)
Number |
Name |
Date |
Kind |
3994974 |
Murakami et al. |
Nov 1976 |
|
4391826 |
Mills et al. |
Jul 1983 |
|
4407819 |
Kiernan et al. |
Oct 1983 |
|
4432995 |
Kiernan et al. |
Feb 1984 |
|
4614746 |
Asato et al. |
Sep 1986 |
|
Foreign Referenced Citations (3)
Number |
Date |
Country |
0117647 |
May 1984 |
EPX |
57-10864 |
Mar 1982 |
JPX |
WO8605075 |
Sep 1986 |
WOX |
Non-Patent Literature Citations (5)
Entry |
Moser & Lewis, Feed Stuffs, 3/3/80, Adding Fat to Sow Diets-An Update. |
Jim Pettigrew, J. An. Sci., 53, 107-17 (1981). |
D. E. Bauman & C. L. Davis, Lactation, vol. II, Biosynthesis of Milk Fat, pp. 26 & 31-75 (1974). |
C. A. 84, 58894v (1976). |
Derwent, 10229x (1976). |
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
901908 |
Aug 1986 |
|
Parent |
802541 |
Nov 1985 |
|