RAPID, ACCURATE IDENTIFICATION, GRAM-POSITIVE ORGANISMS

Information

  • Research Project
  • 3488371
  • ApplicationId
    3488371
  • Core Project Number
    R43AI022762
  • Full Project Number
    1R43AI022762-01A1
  • Serial Number
    22762
  • FOA Number
  • Sub Project Id
  • Project Start Date
    1/1/1987 - 38 years ago
  • Project End Date
    6/30/1987 - 38 years ago
  • Program Officer Name
  • Budget Start Date
    1/1/1987 - 38 years ago
  • Budget End Date
    6/30/1987 - 38 years ago
  • Fiscal Year
    1987
  • Support Year
    1
  • Suffix
    A1
  • Award Notice Date
    -
Organizations

RAPID, ACCURATE IDENTIFICATION, GRAM-POSITIVE ORGANISMS

Gram-Positive bacteria are responsible for a major portion of bacterial infections. Although some species in this group are easily identified, better general methods are still needed. It is expected that this new technology will not only permit identification of the commonly addressed Gram-positive organisms but will permit rapid and accurate identification of less common Gram-positive bacteria which frequently cause serious infection in compromised hosts. Existing products cannot adequately identify these organisms. Biolog holds two patents on a new redox method of testing which can be developed into identification tests for all clinically important microorganisms. These tests will identify an organism based on patterns of carbon source utilization. The method employes a tetrazolium dye to colorimetrically indicate carbon source oxidation. This Phase I study will demonstrate the feasibility of developing a rapid and accurate speciation kit for Gram-Positive bacteria. Two tasks are involved: (1) the development of a suspension medium compatible with the redox chemistry which is tailored to this group of organisms, and (2) a survey of approximately 200 organic chemicals to demonstrate that new and useful speciation tests can be found. Biolog's technology offers many advantages over present technologies. The principal advantages are: (1) speed - for most microorganisms tests can be completed in 2 hours, (2) simplicity - this is an easy to inoculate and read single color method, and (3) accuracy - drawing from thousands of potential carbon source utilization tests should enable us to develop tests that are more accurate than any presently available.

IC Name
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
  • Activity
    R43
  • Administering IC
    AI
  • Application Type
    1
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    856
  • Ed Inst. Type
  • Funding ICs
  • Funding Mechanism
  • Study Section
    MBC
  • Study Section Name
    Microbial Physiology and Genetics Subcommittee 2
  • Organization Name
    BIOLOG, INC.
  • Organization Department
  • Organization DUNS
    103420113
  • Organization City
    HAYWARD
  • Organization State
    CA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    94545
  • Organization District
    UNITED STATES