RAPID DETECTION FOR HTLV III

Information

• Research Project
• 3488624

• ApplicationId

  3488624

• Core Project Number

  R43AI024824

• Full Project Number

  1R43AI024824-01

• Serial Number

  24824

• FOA Number

• Sub Project Id

• Project Start Date

  6/1/1987 - 37 years ago

• Project End Date

  11/30/1987 - 36 years ago

• Program Officer Name

• Budget Start Date

  6/1/1987 - 37 years ago

• Budget End Date

  11/30/1987 - 36 years ago

• Fiscal Year

  1987

• Support Year

  1

• Suffix

• Award Notice Date

  5/29/1987 - 37 years ago

Organizations

• Eli Lilly and Company

This proposal seeks to develop a novel rapid detection system for the identification of antibodies directed against Human T-cell lymphotrophic virus III (HTLV III). It is based on a sandwich fluoro-immunoassay in which an HTLV III antibody containing serum sample is premixed with fluoresceinated HTLV III viral antigen conjugate and subsequently allowed to incubate with an optical grade fiber to which HTLV III viral antigens have been covalently attached. Accumulation of the fluoresceined HTLV III viral antigens on the fiber surface provides a localized concentration of fluorescein which is excited by electromagnetic radiation in the visible wavelength range of 490nm. Fluorescience emission at 525 nm is recaptured by the fiber and propagated the end where it is collected and detected as a light signal output. This system has the potential to become a sensitive, rapid detection assay with simplified sample handling, small sample requirements, and wide field of use in numerous clinical settings including physicians' offices, clinical laboratories, blood banks and field use.

IC Name

• Activity

  R43

• Administering IC

  AI

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  856

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  SSS

• Study Section Name

• Organization Name

  IMCLONE SYSTEMS, INC.

• Organization Department

• Organization DUNS

• Organization City

  NEW YORK

• Organization State

  NY

• Organization Country

  UNITED STATES

• Organization Zip Code

  10014

• Organization District

  UNITED STATES