This invention was made in the course of research sponsored by NIH grant number AG-09215. The Government has certain rights in this invention.
Entry |
---|
Frautschy et al (1991) Proced. Natl. Acad. Sci. 88, 8362-8366. |
Podlisny et al (1992) Neurobiol. Aging 13, 561-567, 1992. |
Ksiezak-Reading et al (1990) J. Neuro Sci. Res. 25, 420-430, 1990. |
Games et al (1992) Neurobiol. Aging 13, 569-576, 1992. |
Hardy et al., "Genetic Mistakes Point the Way for Alzeheimer's Disease" The Journal of NIH Research vol. 5: 46-49 (Nov. 1993). |
Abraham et al., "Immunochemical Identification of the Serine Protease Inhibitor .alpha..sub.1 -Antichymotrypsin in the Brain Amyloid Deposits of Alzheimer's Disease," Cell, 52:487-501, 1988. |
Arai et al., "Defined Neurofilament, T, and .beta.-amyloid precursor protein epitopes distinquish Alzheimer from non-Alzheimer senile plaques," Proc. Natl. Acad. Sci. USA, 87:2249-2253, 1990. |
Arai et al., "Expression Patterns of .beta.-Amyloid Precursor Protein (.beta.-APP) in Neural and Nonneural Human Tissues from Alzheimer's Disease and Control Subjects," Ann. Neurol., 30:686-693, 1991. |
Balin et al., "Neurofilament reassembly in vitro: biochemcal, morphological and immuno-electron microscopic studies employing monoclonal antibodies to defined epitopes," Brain Res., 556:181-195, 1991. |
Baudier et al., "Separation of the Different Microtubule-associated Tau Protein Species from Bovine Brain and Their Mode II Phosphorylation by Ca.sup.2+ /Phospholipid-dependent Protein Kinase C," J. Biol. Chem., 262:17584-17590, 1987. |
Binder et al., "The Distribution of Tau in the Mammalian Central Nervous System," J. Cell Biol., 101:1371-1378, 1985. |
Braak et al., "Occurence of Neuropil Threads in the Senile Human Brain and In Alzheimer's Disease: A Third Location of Paired Helical Filaments Outside of Neurofibrillary Tangles and Neuritic Plaques," Neurosci. Lett., 65:351-355, 1986. |
Bramblett et al., "Regions with Abundant Neurofibrillary Pathology in Human Brain Exhibit a Selective Reduction in Levels of Binding-Competent .tau. and accumulation of Abnormal .tau.-Isoforms (A68 Proteins)," Lab. Invest.66:212-222, 1992. |
Candy et al., "Alumionsilicates and Senile Plaque Formation in Alzheimer's Disease," Lancet, 354-356, 1986. |
Candy et al., "Aluminum Accumulation in Relation to Senile Plaque and Neurofibrillary Tangle Formation in the Brains of Patients with Renal Failure", J. Neurol. Sci. 107: 210-218 (1992). |
Cole et al., "Ubiquitin-protein conjugates in Alzheimer's lesions," Neurosci. Lett., 79:207-212, 1987. |
Garruto et al., "Imaging of calcium and aluminum in neurofibrillary tangle-bearing neurons in parkinsonism-dementia of Guam,"Proc. Natl. Acad. Sci. USA, 81:1875-1879, 1984. |
Goedert et al., "The abnormal phosphorylatin of tau protein at Ser-202 in Alzheimer disease recapitulares phosphorylation during development," Proc. Natl. Acad. Sci. USA, 90:5066-5070, 1993. |
Goedert et al., "Tau Proteins of Alzheimer Paired Helical Filaments: Abnormal Phosphorylation of All Six Brain Isoforms,"Neuron, 8:159-168, 1992. |
Gollin et al., ".alpha..sub.1 -Antitrypsin and in .alpha..sub.1 -antichymotrypsin are in the lesions of Alzeheimer's disease," NeuroReport, 3:201-203, 1992. |
Good et al., "Selective Accumulation of Aluminum and Iron in the Neurofibrillary Tangles of Alzheimer's Disease: A Laser Microprobe (LAMMA) Study," Ann. Neurol., 31:286-292, 1992. |
Greenberg et al., "A preparation of Alzheimer paired helical filaments that displays distinct .tau. proteins by polyacrylamide gel electrophoresis," Proc. Natl. Acad. Sci. USA, 87:5827-5831, 1990. |
Greenberg et al., "Hydrofluoric Acid-treated .tau..sub.PHF Proteins Displays the Same Biochemical Properties as Normal .tau.," J. Biol. Chem., 267:564-569, 1992. |
Grundke-Iqbal et al., "Microtubule-associated Protein Tau," J. Biol. Chem., 261:6084-6089, 1986. |
Hill et al., "Epitopes Located in Spatially Seperate Domains on Each Neurofilament Subunit Are Present in Parkinson's Disease Lewy Bodies," J. Comp. Neurol., 309:150-160, 1991. |
Hyman et al., "Kunitz Protease Inhibitor-Containing Amyloid .beta. Protein Precursor Immunoreactivity in Alzheimer's Disease," Neuropathol. Exp. Neurol., 51:76-83, 1992. |
Joachim et al., "Amyloid .beta.-protein deposition in tissues other than brain in Alzheimer's disease," Nature, 341:226-230, 1989. |
Kidd, "Alzheimer's Disease--An Electron Microscopial Study," Brain, 87:307-319, 1964. |
Kitamoto et al., "Formic Acid Pretreatment Enhances Immunostaining of Cerebral and Systematic Amyloids," Lab. Invest., 57:230-236, 1987. |
Kosik, "Alzheimer's Disease: A Cell Bilogical Perspective," Science, 256:780-783, 1992. |
Ksiezak-Reding et al., "Mapping of the Alz 50 Epitope in Microtubule-Associated Proteins Tau," J. Neurosci. Res., 25:412-419, 1990. |
Lang et al., "Immunological and Conformational Characterization of a Phosphorylated Immunodominant Epitope on the Paired Helical Filaments Found in Alzheimer's Disease," Biochem. Biophys. Commun., 187:783-790, 1992. |
Lee et al., "The disordered neuronal cytoskeleton in Alzheimer's disease," Curr. Opin. Neurobiol., 2:653-656, 1992. |
Lee et al., "A68: A Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau," Science, 251:675-678, 1991. |
Lee et al., "Tau Proteins are Abnormally Expressed in Olfactory Epithelium of Alzheimer Patients and Developmentally Regulated in Human Fetal Spinal Cord",. |
Mori et al., "Ubiquitin Is a Component of Paired Helical Filaments In Alzheimer's Disease," Science, 235:1641-1644, 1987. |
Mullan and Crawford, "Genetic and Molecular Advances in Alzheimer's Disease", Trends Neurosci. 16: 398-403 1993. |
Namba et al., "Apolipoprotein E Immunoreactivity in Cerebral Amyloid Deposits and Neurofibrillary Tangles in Alzheimer's Disease and Kuru Plaque Amyloid in Creutzfeldt-Jakob Disease", Brain Res. 541: 163-166 (1991). |
Papasozomenos et al., "Phosphorylation Determines Two Distinct Species of Tau in the Central Nervous System," Cell Motil. Cytoskeleton, 8:210-226, 1987. |
Perl et al., "Alzheimer's Disease: X-ray Spectrometric Evidence of Aluminum Accumulation in Neurofibrillary Tangle-Bearing Neurons," Science, 208:297-299, 1980. |
Perlmutter et al., "Association Between Vascular Basement Membrane Components and the Lesions of Alzheimer's Disease", J. Neurosci. Res. 30: 673-681 (1991). |
Perry et al., "Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains," Proc. Natl. Acad. Sci. USA, 84:3033-3036, 1987. |
Perry et al., "Association of Heparan Sulfate Proteoglycan with the Neurofibrillary Tangles of Alzheimer's Disease", J. Neurosci. 11: 3679-3683 (1991). |
Perry et al., ".beta. Proein Immunoreactivity is Found in The Majority of Neurofibrillary Tangles of Alzheimer's Disease," Am. J. Pathol., 140:283-290, 1992. |
Piccardo et al., "Histochemical and X-ray microanalytical localization of aluminum in amyotrophic lateral sclerosis and parkinsonism-dementia of Guam," ACTA Neuropathol., 77:1-4, 1988. |
Saunders et al., "Association of apolipoprotein E allele .di-elect cons.4 with late-onset familial and sporadic Alzheimer's disease," Neurol., 43:1467-1472, 1993. |
Schmechel et al., "Increased amyloid .beta.-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease," Proc. Natl. Acad. Sci. USA, 90:9649-9653, 1993. |
Schmidt et al., "Comparative Epitope Analysis of Neuronal Cytoskeletal Proteins in Alzheimer's Disease Senile Plaque Neurites and Neuropil Threads," Lab. Invest., 64:352-357, 1991. |
Selkoe, "Physiological Production of the .beta.-amyloid Protein and the Mechanism of Alzheimer's Disease", Trends Neurosci., 16:403-409, 1993. |
Shaw et al., "Ubiquitin and microtubule-associated protein tau immunoreactivity each define distinct structures with differing distributions and solubility properties in Alzheimer brain," Proc. Natl. Acad. Sci. USA, 85:2854-2858, 1988. |
Shin et al., "Hydrated Autoclave Pretreatment Enhances TAU Immunoreactivity in Formalin-Fixed Normal and Alzheimer's Disease Brain Tissue," Lab. Invest., 64:693-702, 1991. |
Shin et al., "Increased Tau Accumulation in Senile Plaques as a Hallmark in Alzheimer's Disease," Am. J. Pathol., 134:1365-1371, 1989. |
Shin et al., "Alzheimer disease A68 proteins injected into rat brain induce codeposits of .beta.-amyloid, ubiquitin, and .alpha.1-antichymotrypsin," Proc. Natl. Acad. Sci. USA, 90:6825-6828, 1993. |
Smith et al., "Measurment of Protein Using Bicinchoninic Acid," Anal. Biochem., 150:76-85, 1985. |
Snow et al., "The Presence of Heparan Sulfate Proteoglycans in the Neuritic Plaques and Congophilic Angiopathy in Alzheimer's Disease," Am. J. Pathol., 133:456-463, 1988. |
Spillantini et al., "Topographical relationship between .beta.-amyloid and tau protein epitopes in tangle-bearing cells in Alzheimer disease," Proc. Natl. Acad. Sci. USA, 87:3952-3956, 1990. |
Springall et al., "The Potential of the immunogold-silver staining method for paraffin sections," Histochem, 81:603-608, 1984. |
Tohyama et al., "Molecular Milestones That Signal Axonal Maturation and the Committment of Human Spinal Cord Precursor Cells to the Neuronal or Glial Phenotype in Development", J. Comp. Neurol. 3100: 285-299 (1991). |
Trojanowski et al., "Altered Tau and Neurofilament Proteins in Neuro-Degenerative Diseases: Diagnostic Implications for Alzheimer's Disease and Lewy Body Dementias," Brain Pathol., 3:45-54, 1993. |
Trojanowski et al., "Distribution of Tau Proteins in the Normal Human Central and Peripheral Nervous System," J. Histochem. Cytochem., 37:209-215, 1989. |
Vallee, "A Taxol-dependent Procedure for the Isolation of Microtubules and Microtubule-associated Proteins (MAPs)," J. Cell Biol., 92:435-442, 1982. |
Wisniewski and Frangione, "Apolipoprotein E: A Pathological Chaperone Protein in Patients with Cerebral and Systemic Amyloid", Neurosci. Lett. 135: 235-238 (1992). |
Wolozin et al., "A Neuronal Antigen in the Brains of Alzeheimer Patients," Science, 232:648-650, 1986. |
Yamaguchi et al., "Secondary Desposition of Beta Amyloid within Extracellular Neurofibrillary Tangles in Alzheimer-type Dementia," Am. J. Pathol., 138:699-705, 1991. |
Bondareff et al., "Molecular Analysis of Neurofibrillary Degeneration in Alzheimer's Disease", Am. J. of Pathology 137: 711-723 (1990). |
Kondo et al., "The Carboxyl Third of Tau is Tightly Bound to Paired Helical Filaments", Neuron 1: 827-834 (1988). |
Okazaki et al., "Staurosporine, a Novel Protein Kinase Inhibitor, Enhances HL-60-Cell Differentiation Induced by Various Compounds", Exp. Hematol. 16: 42-48 (1988). |
Seubert et al., "Isolation and Quantification of Soluble Alzheimer's .beta.-Peptide From Biological Fluids", Nature 359: 325-327 (1992). |
Shoji et al., "Production of the Alzheimer Amyloid .beta. Protein by Normal Proteolytic Processing", Science 258: 126-129 (1992). |
Wischik et al., "Isolation of a Fragment of Tau Derived from the Core of the Paired Helical Filament of Alzheimer Disease", Proc. Natl. Acad. Sci. USA 85: 4506-4510 (1988). |