The disclosure claims the priority of Chinese Patent Application No. 202011642583X, filed to the Chinese Patent Office on Dec. 31, 2020 and entitled “Reagent Filling Device and Sample Analyzer with Reagent Filling Device”, which is incorporated in its entirety herein by reference.
The disclosure relates to a sample analyzing equipment, and in particular to a reagent filling device and a sample analyzer with the reagent filling device.
Taking a full-automatic biochemical analyzer as an example, which is an instrument of measuring a specific chemical component in body fluid according to a principle of photoelectric colorimetry, and may mainly include a reagent storage system, a sample adding system, a reaction system, an optical system and a fluid circuit control system. Wherein, a reagent filling device in the sample adding system is indispensable and takes charge of absorbing a reagent from the reagent storage system and adding it to a colorimetric cup in the reaction system. In a high-speed full-automatic biochemical analyzer, double circles of the colorimetric cups are arranged in the reaction system from inside to outside generally, therefore two sets of reagent filling devices respectively corresponding to the inner circle colorimetric cups and the outer circle colorimetric cups are needed. In this way, the reagent is filled independently into the inner circle colorimetric cups and the outer circle colorimetric cups. How to reasonably design two sets of reagent filling devices to improve working efficiency of the instrument and reduce an occupied space of parts has always been a technical bottleneck that the high-speed automatic biochemical analyzer faces.
Three reagent filling devices are provided in the related art, and limitations are as follows respectively.
1. A reagent filling device moving circularly and moving up and down is characterized in that two arm components are arranged on the same side, and the two arm components may move at the same time only and finish filling of the reagent in the same direction and the same angle. The two arm components may not move independently, and the working efficiency is low.
2. The reagent filling device moving circularly and moving up and down is characterized in that a center of rotation of its horizontal circular motion is positioned on its structural body only. Two arm components need to be oppositely arranged in order that the two arm components may move independently without interfering with each other. However, a large area of plane of the instrument may be occupied due to an opposite arrangement, and a whole machine may occupy a large area inevitably. Moreover, due to the opposite arrangement, an angle of rotation of the arm component may be greater than 180° when moving and a horizontal motion track is long, accordingly a higher requirement on a motion load to be driven is put forward within a limited sample adding cycle of the high-speed automatic biochemical analyzer.
3. A reagent filling device of performing X, Y and Z three-dimensional movement is further provided in the related art, and the reagent filling device may take a sample and the reagent within a rectangle area at any position. But identically, the reagent filling device has a big volume and occupies a large area of plane of the instrument, and accordingly it is not conducive to layout of the whole machine. Moreover, the reagent filling device is complicated in structure, it is easy to make a mistake in control of software, the cost is high, and it is hard to popularize.
A main objective of the disclosure is to provide a reagent filling device and a sample analyzer with the reagent filling device, as to solve the problem that a reagent filling device of a sample analyzer in the related art may not take into account both independent motion and space occupation.
To achieve the above mentioned objective, according to an aspect of the disclosure, a reagent filling device is provided. The reagent filling device may include a base, a horizontal rotation component, a vertical lifting component and a cantilever component. Wherein, the horizontal rotation component is connected with the base, the vertical lifting component is connected with the horizontal rotation component, and the vertical lifting component is movable in a vertical direction relative to the base, the cantilever component is connected with the vertical lifting component, the vertical lifting component may drive the cantilever component to move along the vertical direction, and the cantilever component is rotatably arranged relative to the vertical lifting component. There are a plurality of cantilever components, and the plurality of cantilever components are arranged in a staggered manner along a vertical direction, the plurality of cantilever components being arranged on a same side. The cantilever component may include a cantilever body, and a length of the cantilever body of at least one cantilever component of the plurality of cantilever components is greater than a length of a cantilever body of each of the rest cantilever components of the plurality of cantilever components. The each cantilever component is configured to add a reagent in a reagent disc to a reaction cup in a reaction disc.
In some embodiments, there are a plurality of horizontal rotation components and plurality of vertical lifting components. The plurality of horizontal rotation components are arranged corresponding to the plurality of vertical lifting components one by one, and the each cantilever component is provided with one horizontal rotation component and one vertical lifting component correspondingly.
In some embodiments, a projection of a center of rotation of the cantilever component on a horizontal plane is positioned in the reagent disc.
In some embodiments, the vertical lifting component may include a lifting body, a first transmission portion, a second transmission portion, a transmission part and a transmission shaft, wherein, the first transmission portion is arranged on a first end of the lifting body, the first transmission portion is connected with the horizontal rotation component, the second transmission portion is arranged on a second end of the lifting body, and the cantilever component is connected with the second transmission portion. A first end of the transmission part is connected with the first transmission portion, a second end of the transmission part is connected with the second transmission portion, and the horizontal rotation component transmits power to the second transmission portion through the first transmission portion and the transmission part, as to drive the cantilever component to rotate. The second transmission portion is connected with the transmission shaft, the cantilever component is connected with another end of the transmission shaft, and an axis center of the transmission shaft is the center of rotation of the cantilever component.
In some embodiments, the transmission shaft may include: a first transmission shaft and a second transmission shaft, and a length of the first transmission shaft being greater than a length of the second transmission shaft.
In some embodiments, the transmission part is a transmission belt, or the transmission part is a rack or a chain.
In some embodiments, the horizontal rotation component may include a first drive portion and a ball spline shaft, wherein, the first drive portion is connected with the base, the ball spline shaft is connected with the first drive portion, the first transmission portion is sleeved on a peripheral side of the ball spline shaft, and the first drive portion is configured to drive the ball spline shaft to rotate, in this way the ball spline shaft drives the first transmission portion to rotate.
In some embodiments, the vertical lifting component may include a second drive portion, a ball screw and a screw nut, wherein, the second drive portion is connected with the base, the ball screw is connected with the second drive portion, the screw nut is sleeved on a peripheral side of the ball screw and connected with the lifting body, and the second drive portion may drive the lifting body to drive the cantilever component to move along the vertical direction.
In some embodiments, the lifting body is provided with an assembling hole for mounting the screw nut, and the assembling hole is positioned between the first transmission portion and the second transmission portion.
In some embodiments, the first transmission portion may include a first sleeve, the first sleeve is sleeved on the ball spline shaft, the first sleeve is connected with the lifting body, and the transmission part is connected with the first sleeve. When the second drive portion drives the lifting body to move along the vertical direction, the lifting body drives the first sleeve to move relative to the ball spline shaft along the vertical direction. When the first drive portion drives the ball spline shaft to rotate, the ball spline shaft drives the first sleeve to rotate horizontally relative to the lifting body, as to drive the cantilever component to rotate through the transmission part.
In some embodiments, a peripheral surface of the first sleeve is fixedly provided with a second sleeve, the first sleeve is connected with the lifting body through the second sleeve, an end of the second sleeve is connected with the transmission part, and the first sleeve and the second sleeve are rotatably arranged relative to the lifting body.
In some embodiments, a peripheral surface of the second sleeve is provided with engaging teeth in cooperation with the transmission part.
In some embodiments, the second transmission portion may include a transmission disc, the transmission disc is moveably connected with the lifting body, the transmission disc is connected with the transmission shaft, a peripheral surface of the transmission disc is provided with engaging teeth in cooperation with the transmission part, and the transmission disc may drive the transmission shaft to rotate.
In some embodiments, a first end of the cantilever body is connected with the transmission shaft, the cantilever component may further include an anti-collision mechanism and a reagent needle, wherein, the anti-collision mechanism is connected with a second end of the cantilever body, and the reagent needle is connected with the anti-collision mechanism.
In some embodiments, the reagent disc has a plurality of circles of reagent bottles along its radial direction, the reaction disc has a plurality of circles of reaction cups along its radial direction, and the cantilever component is configured to add the reagent in each layer of the reagent bottles to the reaction cups in the reaction disc.
In some embodiments, the plurality of circles of reagent bottles may include at least two circles of reagent bottles, and the two circles of reagent bottles may include inner circle reagent bottles and outer circle reagent bottles. The plurality of circles of reaction cups may include at least two circles of reaction cups, and the two circles of reaction cups may include inner circle reaction cups and outer circle reaction cups. The cantilever component may include a first cantilever component and a second cantilever component, and a length of a cantilever body of the first cantilever component is greater than a length a cantilever body of the second cantilever component. The first cantilever component is configured to add the reagent in the inner circle reagent bottle to at least one of the inner circle reaction cups and the outer circle reaction cups, and the second cantilever component is configured to add the reagent in the outer circle reagent bottle to at least one of the inner circle reaction cups and the outer circle reaction cups. Or, the first cantilever component is configured to add the reagent in the outer circle reagent bottle to at least one of the inner circle reaction cups and the outer circle reaction cups, and the second cantilever component is configured to add the reagent in the inner circle reagent bottle to at least one of the inner circle reaction cups and the outer circle reaction cups.
In some embodiments, an angle of rotation a of the first cantilever component satisfies: 0<a≤120°, and/or, an angle of rotation b of the second cantilever component satisfies: 0<b≤90°.
In some embodiments, the vertical lifting component may further include a supporting shaft sleeve, and the supporting shaft sleeve is configured to support the first cantilever component.
According to another aspect of the disclosure, a sample analyzer is provided. The sample analyzer may include the abovementioned reagent filling device.
In some embodiments, the reagent filling device may include a plurality of reagent discs and the reagent filling devices arranged corresponding to the plurality of reagent discs one by one.
With the adoption of the technical solution of the disclosure, a structure of the reagent filling device of the sample analyzer is optimized, in this way the reagent filling device has the horizontal rotation component, the vertical lifting component and the cantilever component. The cantilever components are gathered together, thereby greatly reducing an occupied space. The cantilever components are staggered up and down, and a long cantilever and a short cantilever are designed, in this way the plurality of cantilever components move independently in a horizontal direction and a vertical direction, the reagent may be absorbed from the inner circle and the outer circle of the reagent disc, no interference will be caused, and working efficiency will be improved.
The accompanying drawings, which constitute a part of the present disclosure, are used to provide a further understanding of the disclosure, and the exemplary embodiments of the disclosure and the description thereof are used to explain the disclosure, but do not constitute improper limitations to the disclosure. In the drawings:
Wherein, the abovementioned drawings may include the following reference numbers.
1. Reagent disc; 2. Reaction disc; 3. Reagent filling device; 1022. Coupler; 1023. Supporting bearing; 402. Line-base fixed plate; 10. Base; 20. Horizontal rotation component; 30. Vertical lifting component; 40. Cantilever component; 100. Reaction cup; 31. Lifting body; 32. First transmission portion; 33. Second transmission portion; 34. Transmission belt; 35. Transmission shaft; 351. First transmission shaft; 352. Second transmission shaft; 212. First drive portion; 212. Ball spline shaft; 36. Second drive portion; 37. Ball screw; 38. Screw nut; 39. Assembling hole; 321. First sleeve; 322. Second sleeve; 3221. Bearing; 3222. Bond; 331. Transmission disc; 41. Cantilever body; 42. Anti-collision mechanism; 43. Reagent needle; 200. Reagent bottle; 44. First cantilever component; 45. Second cantilever component; 47. Supporting shaft sleeve.
It is to be noted that embodiments in the disclosure and features in the embodiments may be combined with each other without conflict. The disclosure will be described below in detail with reference to drawings and in combination with the embodiments.
It should be noted that terms used wherein are merely intended to describe specific embodiments rather than limit exemplary embodiments according to the disclosure. Unless otherwise pointed out explicitly, a singular form used wherein is also intended to include a plural form. In addition, it should also be understood that the term “include” and/or “comprise” used in the description indicates that there are features, steps, operations, devices, assemblies and/or combinations thereof.
It is to be noted that terms “first”, “second” and the like in the description, claims and the abovementioned drawings of the disclosure are adopted not to describe a specific sequence but to distinguish similar objects. It should be understood that the terms used in such a way may be exchanged where appropriate, in order that the embodiments of the disclosure described here can be implemented in a sequence other than sequences graphically shown or described here. In addition, terms “include” and “have” and any variations thereof are intended to cover non-exclusive inclusions. For example, it is not limited for processes, methods, systems, products or devices containing a series of steps or units to clearly list those steps or units, and other steps or units which are not clearly listed or are inherent to these processes, methods, products or devices may be included instead.
Now, the exemplary embodiments according to the disclosure will be described below in detail with reference to drawings. However, these exemplary embodiments may be implemented in many different ways and should not be explained to limit the embodiments elaborated wherein. It should be understood that these embodiments are provided to make the disclosure thoroughly and integrally disclosed, and sufficiently pass a conception of the exemplary embodiments to those of ordinary skill in the art. In the drawings, for clarity, thicknesses of a layer and an area may be enlarged, and identical reference numbers are used to mark identical devices. Therefore, descriptions thereof are omitted.
To solve the problem that a reagent filling device of a sample analyzer in the related art occupies a large area, the disclosure provides a reagent filling device and a sample analyzer, wherein, the sample analyzer includes the reagent filling device 3.
Further, the sample analyzer includes a plurality of reagent discs 1 and the reagent filling devices 3 arranged corresponding to the plurality of reagent discs 1 one by one.
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Through optimizing a structure of the reagent filling device of the sample analyzer, the reagent filling device has the horizontal rotation component 20, the vertical lifting component 30 and the cantilever component 40, wherein, the cantilever component 40 is connected with the vertical lifting component 30 and the horizontal rotation component 20, the cantilever component 40 may rotate relative to the vertical lifting component 30, and the projection of the center of rotation of the cantilever component 40 on the horizontal plane is positioned in the reagent disc 1. In this way, on one hand, when adding the reagent in the reagent disc 1 to the reaction cup 100 in the reaction disc 2, the cantilever component 40 needs to rotate for a small angle only and addition of the reagent may be realized, thereby greatly reducing an angle of rotation of the cantilever component 40. On the other hand, it is conducive to reducing a cantilever length of the cantilever component 40, accordingly it is conducive to designing the compact reagent filling device, the reagent filling device is ensured to have a small overall volume, and further the reagent filling device is guaranteed not to occupy a big mounting space. In addition, due to the small angle of rotation of the cantilever component 40, that it is conducive to lowering a requirement on a motion load of a motor within a limited sample adding period of the sample analyzer is ensured.
It is to be noted that the cantilever components are gathered together in the disclosure, thereby greatly reducing the mounting space. The cantilever components are staggered up and down, and a long cantilever and a short cantilever are designed, in this way the plurality of cantilever components may move independently in a horizontal direction and a vertical direction, and the reagent may be absorbed from the inner circle and the outer circle of the reagent disc, no interference will be caused, and working efficiency will be improved. Moreover, the center of rotation is positioned outside, in this way the cantilever component needs to rotate for a small angle only and addition of the reagent may be realized, and accordingly the angle of rotation of the cantilever component is greatly reduced, and the occupied space is reduced.
It is to be noted that the reagent in the reagent disc 1 in the disclosure may be a sample, a cleaning solution, etc.
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Optionally, in an embodiment not shown in the disclosure, the transmission part is a rack or a chain.
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To ensure that the cantilever component 40 absorbs the reagent in the reagent disc 1, as shown in
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Optionally, the vertical lifting component 30 is not limited to transmission modes of the ball screw 37 and the screw nut 38, and may include a trapezoidal screw, a synchronous belt or a chain, etc. as well.
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Optionally, a peripheral surface of the second sleeve 322 is provided with engaging teeth in cooperation with the transmission part. In this way, transmission between the second sleeve 322 and the transmission part is realized through a belt pulley, and transmission stability of the second sleeve 322 and the transmission part is ensured, It is conducive to designing the compact reagent filling device, and transmission stability of the second sleeve 322 and the transmission part is guaranteed as well.
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Optionally, there are a plurality of cantilever components 40, and the plurality of cantilever components 40 are arranged in a staggered manner along the vertical direction, the plurality of cantilever components 40 being arranged on a same side, each cantilever component 40 is correspondingly provided with one horizontal rotation component 20 and one vertical lifting component 30. In this way, all cantilever components 40 are ensured not to interfere with each other when absorbing or adding the reagent, and accordingly adding reliability of the reagent filling device is guaranteed. In addition, the plurality of cantilever components 40 are conducive to improving adding efficiency of the reagent filling device.
Optionally, a length of the cantilever body 41 of at least one cantilever component 40 of the plurality of cantilever components 40 is greater than a length of the cantilever body 41 of the rest cantilever components 40. In this way, all cantilever components 40 are ensured not to interfere with each other when absorbing or adding the reagent.
Optionally, the reagent disc 1 has a plurality of circles of reagent bottles 200 along its radial direction, the reaction disc 2 has a plurality of circles of reaction cups 100 along its radial direction, and the cantilever component 40 is configured to add the reagent in each circle of the reagent bottles 100 to the reaction cups 100 in the reaction disc 2. In this way, it is conducive to improving the filling efficiency of the reagent filling device.
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It is to be noted that the sample analyzer in the disclosure may be a chemiluminescent analyzer, a coagulation analyzer, a haemacytometer analyzer, etc.
In order to facilitate description, a spatial relative term may be used here, such as “over”, “above”, “on an upper surface” and “on”, to describe a spatial location relation between a device or a feature shown in the drawing and other devices or other features. It is to be understood that the spatial relative term aims at including different orientations of the device during use or operation outside the orientation described in the drawing. For example, if the device in the drawing is inverted, it may be described as that the device “above other devices or other structures” or “over other devices or other structures” shall be positioned “under other devices or other structures” or “below other devices or other structures”. Therefore, an exemplary term “above” may include two orientations: “above” and “under”. As an alternative, the device may be positioned with other different modes (90° rotation or positioned at other orientations), and the spatial relative description used here needs to be explained correspondingly.
Beside the above, it should be further noted that “one embodiment”, “another embodiment”, “embodiment” and the like mentioned in the description mean that specific features, structures or characteristics described in connection with the embodiment are included in at least one embodiment described generally in the disclosure. Identical expression occurring in many places in the description does not necessarily refer to the same embodiment. And further, when describing one specific feature, structure or characteristic in connection with any embodiment, what is claimed is that realization of the feature, structure or characteristic in connection with other embodiments should fall within the scope of the disclosure.
In the abovementioned embodiments, the description of the each embodiment has particular emphasis, and the relevant description of other embodiments may be used for reference in case of parts not detailed in one embodiment.
The above is only preferred embodiments of the disclosure and is not intended to limit the disclosure. Those skilled in the art may make various modifications and variations. Any modifications, equivalent replacements, improvements and the like made within the spirit and principle of the disclosure shall fall within the scope of protection of the disclosure.
Number | Date | Country | Kind |
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202011642583.X | Dec 2020 | CN | national |