Real-time Detection of GPCR Conformational Change

Information

• Research Project
• 6992536

• ApplicationId

  6992536

• Core Project Number

  R43GM075439

• Full Project Number

  1R43GM075439-01

• Serial Number

  75439

• FOA Number

• Sub Project Id

• Project Start Date

  8/15/2005 - 19 years ago

• Project End Date

  6/30/2007 - 17 years ago

• Program Officer Name

  DUNSMORE, SARAH

• Budget Start Date

  8/15/2005 - 19 years ago

• Budget End Date

  6/30/2007 - 17 years ago

• Fiscal Year

  2005

• Support Year

  1

• Suffix

• Award Notice Date

  8/9/2005 - 19 years ago

Organizations

• BIODESY, LLC

[unreadable] DESCRIPTION (provided by applicant): A novel, optical detection system for detecting conformational change in a GPCR (G Protein-coupled receptor) has been devised. The detection system is based on second-harmonic generation, a nonlinear optical technique. Phase I specific aims are final construction, control experiments and optimization to demonstrate feasibility of the detection system. The beta-2 adrenergic receptor, a prototypical GPCR, will be the model protein for Phase I studies. Drug screening and basic scientific studies of receptor activation are the long-term objectives of the proposed detection system. [unreadable] [unreadable]

IC Name

• Activity

  R43

• Administering IC

  GM

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

  100000

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  859

• Ed Inst. Type

• Funding ICs

  NIGMS:100000\

• Funding Mechanism

• Study Section

  ZRG1

• Study Section Name

  Special Emphasis Panel

• Organization Name

  BIODESY, LLC

• Organization Department

• Organization DUNS

  169610016

• Organization City

  NEW YORK

• Organization State

  NY

• Organization Country

  UNITED STATES

• Organization Zip Code

  10032

• Organization District

  UNITED STATES