Claims
- 1. A recombinant Marek's disease virus (MDV), which is genetically stable in vivo and able to persistently infect a host, having a gene expression cassette incorporated in a non-essential region of the genome, wherein the gene expression cassette contains an exogenous gene operatively linked to an MDV gB promoter; wherein the MDV gB promoter comprises the sequence of about 61 to 557 nucleotides upstream of the gB coding sequence endogenous to the MDV, and the exogenous gene encodes a hormone, a cytokine, or a vaccine antigen effective for prevention of chicken virus infectious diseases.
- 2. The recombinant Marek's disease virus (MDV) according to claim 1, wherein said promoter comprises nucleotides 61 to 557 of SEQ ID NO: 1.
- 3. The recombinant Marek's disease virus (MDV) according to claim 1, wherein said promoter consists of nucleotides 61 to 557 of SEQ ID NO:1.
- 4. The recombinant Marek's disease virus (MDV) of claim 1 wherein said exogenous gene encodes a vaccine antigen effective for prevention of chicken viral infectious disease.
- 5. The recombinant Marek's disease virus (MDV) of claim 1 wherein said exogenous gene encodes a hormone or a cytokine.
- 6. A live vaccine for animal which comprises the recombinant herpes virus of claim 1.
- 7. A polyvalent live vaccine for animal which comprises the recombinant herpes virus of claim 1.
- 8. The vaccine of claim 6 wherein the animal is chicken.
Priority Claims (1)
Number |
Date |
Country |
Kind |
7-160106 |
Jun 1995 |
JPX |
|
Parent Case Info
This is a rule 371 application based on the priority date of PCT/JP/96/01428 filed May 28, 1996.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/JP96/01428 |
5/28/1996 |
|
|
1/30/1997 |
1/30/1997 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO96/38565 |
12/5/1996 |
|
|
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
5171677 |
Sakaguchi et al. |
Dec 1992 |
|
5558860 |
Ross et al. |
Sep 1996 |
|
5659153 |
Ishikawa et al. |
Aug 1997 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
6-022757 |
Feb 1994 |
JPX |
9002803 |
Mar 1990 |
WOX |