Schlesinger, J. J., et al., 1987, “Protection of mice against dengue 2 virus encephalitis by immunization with the dengue 2 virus non-structural glycoprotein NS1”, J. Gen. Virol. 68:853-857.* |
Men, R., et al., 1991, “Carboxy-terminally truncated dengue virus envelope glycoproteins expressed on the cell surface and secreted extracellularly exhibit increased immunogenicity in mice”, J. Virol. 65(3):1400-1407.* |
Patarapotikul, J., et al., 1993, “Western blot analysis of antigens specifically recognized by natural immune responses of patients with Japanese encephalitis infections”, Southeast Asian J. Trop. Med. Pub. Health 24(2):269-276.* |
Cardosa, M. J., 1998, “Dengue vaccine design: issues and challenges”, Brit. Med. Bull. 54(2):395-405.* |
Bancroft, W. H., 1987, “Current status of dengue vaccines and prospects for the future”, PRHSJ 6(1):23-26.* |
Lai, C. J., et al., 1998, “Evaluation of molecular strategies to develop a live dengue vaccine”, Clin. Diag. Virol. 10:173-179.* |
Culp, J. S. et al., 1991, “Regulated expression allows high level production and secretion of HIV-1 gp120 envelope glycoprotein in Drosophila Schneider cells”, Bio/Technol. 9:173-177.* |
Bray, M. et al., Mice Immunized With Recombinant Vaccinia Virus Expressing Dengue 4 Virus Structural Proteins With Or Without Nonstructural Protein NS1 Are Protected Against Fatal Dengue Virus Encephalitis, J. Virol., (1989) 63(6):2853-6. |
Cane, P. A. et al., Reduction Of Yellow Fever Virus Mouse Neurovirulence By Immunization With A Bacterially Synthesized Non-Structural Protein (NS1) Fragment, J. Gen. Virol., (1988) 69:1241-6. |
Chambers, T. J. et al., Flavivirus Genome Organization, Expression, And Replication, Annu. Rev. Microbiol., (1990) 44: 649-88. |
Crooks, A. J. et al., The NS1 Protein Of Tick-Borne Encephalitis Virus Forms Multimeric Species Upon Secretion From The Host Cell, J. Gen. Virol., (1994) 75:3453-60. |
Eckels, K. H. et al., Dengue-2 Vaccine: Preparation From A Small-Plaque Virus Clone, Infect. Immun., (1980) 27(1): 175-80. |
Falconar, A.K.I. et al., Immunoaffinity Purification Of Native Dimer Forms Of The Flavivirus Non-Structural Glycoprotein, NS1, J. Virol. Meth., (1990) 30:323-32. |
Falgout, B. et al., Immunization Of Mice With Recombinant Vaccinia Virus Expressing Authentic Dengue Virus Nonstructural Protein NS1 Protects Against Lethal Dengue Virus Encephalitis, J. Virol., (1990) 64(9):4356-63. |
Falgout, B. et al., Proper Processing Of Dengue Virus Nonstructural Glycoprotein NS1 Requires The N-Terminal Hydrophobic Signal Sequence And The Downstream Nonstructural Protein NS2a., J. Virol., (1989) 63(5):1852-60. |
Feighny, R. et al., Purification Of Native Dengue-2 Viral Proteins And The Ability Of Purified Proteins To Protect Mice, Am. J. Trop. Med. Hyg., (1992) 47(4):405-12. |
Hahn, Y. S. et al., Nucleotide Sequence Of Dengue 2 RNA And Comparison Of The Encoded Proteins With Those Of Other Flaviviruses., Virol., (1988) 162:167-80. |
Hall, R. A. et al., Protective Immune Responses To The E And NS1 Proteins Of Murray Valley Encephalitis Virus In Hybrids Of Flavivirus-Resistant Mice, J. Gen. Virol., (1996) 77:1287-94. |
Halstead, S. B., Pathogenesis Of Dengue: Challenges To Molecular Biology, Science, (1988) 239:476-81. |
Hsieh, P. et al., Regulation Of Asparagine-Linked Oligosaccharide Processing, J. Biol. Chem. (1984) 259(4):2375-82. |
Jacobs, S. C. et al., Protection Elicited By Replication-Defective Adenovirus Vector Expressing The Tick-Borne Encephalitis Virus Non-Structural Glycoprotein NS1, J. Gen. Virol., (1994) 75:2399-402. |
Kaufman, R. J. Selection And Coamplification Of Heterologous Genes In Mammalian Cells, Meth. Enzymol., (1990) 185:537-66. |
Konishi, E. et al., Comparison Of Protective Immunity Elicited By Recombinant Vaccinia Viruses That Synthesize E Or NS1 Of Japanese Encephalitis Virus, Virol., (1991) 185:401-10. |
Leblois, H. et al., Maturation Of The Dengue-2 Virus NS1 Protein In Insect Cells: Effects Of Downstream NS2A Sequences On Baculovirus-Expressed Gene Constructs, J. Gen. Virol., (1995) 76:979-84. |
Lin, Y. et al., DNA Immunization With Japanese Encephalitis Virus Nonstructural Protein NS1 Elicits Protective Immunity In Mice, J. Virol., (1998) 72(1):191-200. |
Lindenbach, B. D. et al., Trans-Complementation Of Yellow Fever Virus NS1 Reveals A Role In Early RNA Replication, J. Virol., (1997) 71(12):9608-17. |
Mackenzie, J. M. et al., Immunolocalization Of The Dengue Virus Nonstructural Glycoprotein NS1 Suggests A Role In Viral RNA Replication, Virol., (1996) 220:232-40. |
McCown, J. et al., Protection Of Mice Against Lethal Japanese Encephalitis With A Recombinant Baculovirus Vaccine, Am. J. Trop. Med. Hygene, (1990) 42(5):491-99. |
Muylaert, I. R. et al., Genetic Analysis Of The Yellow Fever Virus NS1 Protein: Identification Of A Temperature-Sensitive Mutation Which Blocks RNA Accumulation, J. Virol., (1997) 71(1):291-98. |
Putnak, J. R. et al., Protection Of Mice Against Yellow Fever Virus Encephalitis By Immunization With A Vaccinia Virus Recombinant Encoding The Yellow Fever Virus Non-Structural Proteins, NS1, NS2a And NS2b, J. Gen. Virol., (1990) 71:1697-702. |
Qu, X. et al., Immunoreactivity And Protective Effects In Mice Of A Recombinant Dengue 2 Tonga Virus NS1 Protein Produced In A Baculovirus Expression System, J. Gen. Virol., (1993) 74:89-97. |
Schlesinger, J. J. et al., Protection Against Yellow Fever In Monkeys By Immunization With Yellow Fever Virus Nonstructural Protein NS1, J. Virol., (1986) 60(3):1153-55. |
Schlesinger, J. J. et al., Cell Surface Expression Of Yellow Fever Virus Non-Structural Glycoprotein NS1: Consequences Of Interaction With Antibody., J. Gen. Virol. (1990) 71:593-99. |
Schlesinger, J. J. et al., Protection Against 17D Yellow Fever Encephalitis In Mice By Passive Transfer Of Monoclonal Antibodies To The Nonstructural Glycoprotein gp48 And By Active Immunization With gp48, J. Immunol., (1985) 135(4):2805-9. |
Schlesinger, J. J. et al.,Protection Of Mice Against Dengue 2 Virus Encephalitis By Immunization With The Dengue 2 Virus Non-Structural Glycoprotein NS1, J. Gen. Virol., (1987) 68:853-7. |
Schlesinger, J. J. et al.,The Fc Portion Of Antibody To Yellow Fever Virus NS1 Is A Determinant Of Protection Against YF Encephalitis In Mice, Virol., (1993) 192:132-41. |
Smith, G. W. et al., Synthesis of Proteins and Glycoproteins in Dengue Type 2 Virus-Infected Vero and Aedes Albopictus Cells., J. Gen. Virol., (1985) 66:559-71. |
Tan, B. H. et al., Recombinant Dengue Type 1 Virus NS5 Protein Expressed In Escherichia Coli Exhibits RNA-Dependent RNA Polymerase Activity, Virol., (1986) 216:317-25. |
Van Der Straten, A. et al., Introduction And Constitutive Expression Of Gene Products In Cultured Drosophila Cells Using Hygromycin B Selection, Meth. Mol. Cell. Biol., (1989) 1(1):1-18. |
Wigler, M. et al., Transformation Of Mammalian Cells With Genes From Procaryotes And Eucaryotes, Cell, (1979) 16: 777-85. |
Winkler, G. et al., Evidence That The Mature Form Of The Flavivirus Nonstructural Protein NS1 Is A Dimer, Virol. (1988) 162:187-96. |
Search Report for International Application No. PCT/US99/19707 dated May 16, 2000. |
Feighny et al., (1992) “Purification of Native Dengue-2 Viral Proteins and the Ability of Purifie Proteins to Protect mice” American Journal of Tropical Medicine and Hygiene, vol. 47, No. 4 pp. 405-412. |
Crooks, et al. (1994) “The NSI Protein of Tick-borne Encephalitis Virus Forms Multimeric Species Upon Secretion from the Host Cell” Journal of General Virology, vol. 75, No. 12, pp 3453-3460. |
Patent Cooperation Treaty International Search Report for PCT/US99/19707. |
Despres, P. et al. (1991). “Recombinant Baculoviruses Expressing Yellow Fever Virus E and NS1 Proteins Elicit Protective Immunity in Mice,” Journal of General Virology 72:2811-2816. |