The present disclosure relates generally to medical treatment systems and, more particularly, but not by way of limitation, to reduced-pressure canisters having hydrophobic pores.
Clinical studies and practice have shown that providing a reduced pressure in proximity to a tissue site augments and accelerates the growth of new tissue at the tissue site. The applications of this phenomenon are numerous, but application of reduced pressure has been particularly successful in treating wounds. This treatment (frequently referred to in the medical community as “negative pressure wound therapy,” “reduced-pressure therapy,” or “vacuum therapy”) provides a number of benefits, which may include faster healing and increased formulation of granulation tissue. Typically, reduced pressure is applied to tissue through a porous pad or other manifold device. The porous pad contains cells or pores or pathways that are capable of distributing reduced pressure to the tissue and channeling fluids that are drawn from the tissue. Reduced pressure may also be used for draining fluids or other applications. The fluids removed are typically delivered to a canister.
According to an illustrative embodiment, a reduced-pressure treatment system includes a reduced-pressure canister. The reduced-pressure canister includes a canister body that forms a fluid reservoir and an inlet for receiving fluids from a patient. The reduced-pressure canister also includes a vent portion that has a plurality of pores and a hydrophobic coating over the plurality of pores. A reduced-pressure source is fluidly coupled to the reduced-pressure canister. The reduced-pressure treatment system also includes a reduced-pressure delivery conduit fluidly coupled to the inlet for delivering fluids from the patient to the reduced-pressure canister.
According to an illustrative embodiment, a method of manufacturing a reduced-pressure canister includes the steps of forming a canister body with a fluid reservoir and an inlet for receiving fluids from a patient. The method also includes forming a vent portion in the canister body. The step of forming the vent portion includes forming a plurality of pores in a boundary area of the canister body and applying a hydrophobic coating over the plurality of pores.
According to an illustrative embodiment, a reduced-pressure canister includes a canister body having a fluid reservoir. The reduced-pressure canister has an inlet for receiving fluids from a patient and an integral hydrophobic filter formed within a side or top portion of the canister body. The integral hydrophobic filter includes a plurality of pores and a hydrophobic coating applied to the plurality of pores.
According to an illustrative embodiment, a method of forming a hydrophobic vent on a reduced-pressure canister includes the steps of forming a plurality of apertures on a canister body and applying a hydrophobic coating to the plurality of apertures. In this illustrative embodiment, the step of applying a hydrophobic coating includes applying a fluorocarbon coating in a plasma treatment process.
Other features and advantages of the illustrative embodiments will become apparent with reference to the drawings and detailed description that follow.
The following detailed description of the illustrative, non-limiting embodiments, makes reference to the accompanying drawings that form a part hereof. These embodiments are described in sufficient detail to enable those skilled in the art to practice the invention, and other embodiments may be utilized and that logical structural, mechanical, electrical, and chemical changes may be made without departing from the spirit or scope of the invention. To avoid detail not necessary to enable those skilled in the art to practice the embodiments described herein, the description may omit certain information known to those skilled in the art. The following detailed description is, therefore, not to be taken in a limiting sense, and the scope of the illustrative embodiments are defined only by the appended claims.
Referring now to the drawings and initially and primarily to
The reduced-pressure delivery conduit 112 may fluidly communicate with the tissue site 114 through a tubing adapter 118 and a distribution manifold 122. The distribution manifold 122 may be any material, either bioabsorbable or non-bioabsorbable, if the material is capable of manifolding a reduced pressure to the tissue site 114. In one embodiment, the distribution manifold 122 may be an open-cell, reticulated polyurethane foam. A drape 128 may be placed over the distribution manifold 122 and sealed around a perimeter of the tissue site 114 to maintain reduced pressure at the tissue site 114.
A coupling provides fluid communication between the reduced-pressure delivery conduit 112 and a reduced-pressure source 134. In one implementation, the reduced-pressure source 134 may be a reduced pressure or vacuum pump driven by a motor. In another embodiment, the reduced-pressure source may be a manually-actuated pump such as a compressible bellows pump. In still another embodiment, the reduced-pressure source 134 may be a wall suction port such as are available in hospitals and other medical facilities.
The reduced-pressure source 134 may be housed within a reduced-pressure treatment unit 136, which may also contain sensors, processing units, alarm indicators, memory, databases, software, display units, and user interfaces that further facilitate the application of reduced pressure treatment to the tissue site 114. In one example, a sensor (not shown) may be disposed at or near the reduced-pressure source 134 to determine a source pressure generated by the reduced-pressure source 134. The sensor may communicate with a processing unit that monitors and controls the reduced pressure delivered by the reduced-pressure source 134. Delivery of reduced pressure to the tissue site encourages new tissue growth by maintaining drainage of exudate from the tissue site, increasing blood flow to tissues surrounding the tissue site, and by compressing the distribution manifold into the tissue site, thereby creating microstrain at the tissue site which stimulates new tissue growth.
Referring still to
In the embodiment shown in
The canister body 142 includes an inlet 152 fluidly coupled to the reduced-pressure delivery conduit 112, and an outlet, or vent portion 160. The reduced-pressure treatment system 110 may include a canister filter or other in-line protection filter to prevent fluid from entering the reduced-pressure source 134. The vent portion 160 of the canister body 142 comprises a hydrophobic filter to prevent liquid from exiting the canister body 142 through the vent portion 160. The inlet 152 may be positioned on a wall 178 disposed in a recessed region 180 of the basin portion 144.
The hydrophobic filter of vent portion 160 prevents liquid egress from the canister body 142 while allowing gases or vapor to exit. A hydrophobic filter may be a hydrophobic membrane welded to the canister body 142 in a window or opening. Alternatively, a plurality of pores 162 are formed in the canister body 142 and covered with a hydrophobic coating (e.g., hydrophobic coating 271 of
In such an embodiment, the vent portion 160 includes the integral hydrophobic filter formed within the exit wall 148. Integrating the vent portion 160, which includes or otherwise functions as a hydrophobic filter, into the exit wall 148 may be beneficial for a number of reasons. An integral hydrophobic filter removes the need to weld or fix a filter in place as a separate manufacturing step, thereby mitigating concerns related to welding a filter in place, using mechanical fasters, or using adhesives. Such concerns may include localized stresses, weaknesses associated with the weld(s), and material constraints associated with welded materials. In addition, an integral filter may reduce the overall cost of the reduced-pressure canister because fewer parts and less labor are needed to assemble a canister body 142 for use in a reduced-pressure treatment system 110 or other medical system requiring a reduced-pressure canister.
The vent portion 160 allows fluid communication between the canister body 142 and the reduced-pressure source 134 such that a collection chamber or reservoir portion 166 formed by the canister body 142 can maintain a reduced pressure. This reduced pressure may be transmitted to the tissue site (or other location for a medical application) through the inlet 152. In the reduced-pressure treatment system 110, the inlet 152 delivers the reduced pressure to the reduced-pressure delivery conduit 112, the tubing adapter 118, and the distribution manifold 122. The reduced pressure draws exudate and other fluids from the tissue site 114 into the canister body 142. The hydrophobic filter prevents liquids that that are drawn into the canister body 142 from exiting the canister body 142 through the vent portion 160 and contaminating the reduced-pressure source 134.
As discussed in more detail with regard to
Referring now primarily to
The positions and shapes of the inlet 152, vent portion 160, and entry chamber 170 may vary depending on the shape and configuration of the canister. As such, the positions and shapes of the inlet 152, vent portion 160, and entry chamber 170 may differ from the positioning, shapes, and general configurations described above and shown in the related
A baffle 156 may be provided to reduce the formation of protein bubbles, burst protein bubbles that have formed, and minimize the premature blocking of the vent portion 160. The baffle 156 may have a surfactant coating to reduce the surface energy of the bubbles.
The baffle 156 creates a tortuous pathway (as illustrated, for example, by line 192) for fluid entering and traveling through the canister body 142. This tortuous pathway minimizes the risk of premature blocking of the hydrophobic filter by liquid entering the canister body 142. Additionally, the baffle 156 serves to prevent protein bubbles in the liquid exudate from forming or to block bubbles that have formed from reaching the vent portion 160. The baffle 156 also prevents or substantially reduces line-of-sight between the entry chamber 170 and the vent portion 160.
It should be noted that other means exist for creating a tortuous pathway for fluid entering the canister body 142. For example, a porous, reticulated foam such as a polyurethane foam may be positioned within the entry chamber 170. The reticulated nature of the foam minimizes bubble formation near the open end of the entry chamber 170, which limits protein deposition on the vent portion 160. Similarly, other foams or materials may be placed within the entry chamber 170 or between the entry chamber 170 and the vent portion 160 to prevent premature blocking of the hydrophobic filter. In canisters that may not include a separate entry chamber, a porous foam may be placed anywhere in the canister to prevent or reduce protein deposition on the vent portion 160.
Referring now primarily to
Referring now primarily to
The pores 162 may be sized to function as a barrier to bacteria or viruses. In cases where the hydrophobic filter is intended to function as a barrier to bacteria, the plurality of pores 162 may have a diameter of, for example, 0.5 to 1 microns. In cases where the hydrophobic filter is intended to function as a barrier to a virus, the plurality of pores 162 may have a smaller diameter of, for example, 0.25 micron. The size of the pores may even be adjusted to provide protection against specific types of bacteria. Generally, holes of 1 micron in diameter, arranged in a tortuous path, are sufficiently small to prevent the passage of some bacteria and fluid through a hydrophobic filter operated at low level differential pressures.
Desired hydrophobic properties may be given to the vent portion 160 by applying a surface treatment process to the vent portion 160 of the reduced-pressure canister over the apertures, e.g., pores 162, micro-slits 262, or micro-holes 363. An example of such a surface treatment process is shown in
Referring now to
Referring now primarily to
The heated plasma stream 275 cools as the plasma stream 275 moves away from the plasma coating unit 270. The work piece, e.g., the canister lid portion 146, is some distance away from the plasma coating unit 270 where the canister lid portion 146 can receive the coating material 271 at an ideal temperature for deposition. According to an illustrative embodiment, a plasma deposition process deposits a hydrophobic coating onto the vent portion 160 portion of the lid portion 146 of the canister 137. The coating may be a fluorocarbon, heptadecafluorodecylacylate, acrylates containing haloalkyl (e.g., fluoroalkyl) or perhaloalkyl (e.g. perfluoroalkyl) groups, hexamethyldisiloxanes, and other substituted hydrocarbons, such as 1,2-epoxy-3-phenoxy-propane. In the plasma treatment process, the hydrophobic coating chemically bonds to the substrate, i.e., to the exit wall 148 of the lid portion 146 of the canister, to resist mobility or removal of the hydrophobic coating from the substrate.
In most applications, it is undesirable that any liquid pass through the vent portion 160 to the reduced-pressure source 134. As such, the reduced-pressure treatment unit 136 may include a pressure sensor that monitors the pressure of the reduced-pressure treatment unit 136. Where a canister includes a hydrophobic filter, the hydrophobic filter prevents liquid from passing through the exit wall until the pressure differential between the fluid reservoir of the canister body 142 and the reduced-pressure treatment unit 136 reaches the breakthrough pressure of the filter, “P(b).” As such, the reduced-pressure unit may monitor the pressure differential between the canister body 142 and the reduced-pressure treatment unit 136. Before the pressure differential reaches the breakthrough pressure, P(b), of the hydrophobic filter, the reduced-pressure treatment unit 136 may deactivate the reduced-pressure source, thereby preventing fluid from entering the reduced-pressure treatment unit 136.
The breakthrough pressure, P(b), of a hydrophobic filter resulting from the plasma treatment process is a function of the size of the holes that form the filter, the surface tension of the liquid, and the contact angle of the surface. In turn, the contact angle of the surface is a measure of the hydrophobicity of the surface. Here, the equation “P(b)=4g(cos q)/D” defines the breakthrough pressure of the hydrophobic filter, where g is the surface tension of the liquid, q is the contact angle between the liquid and the surface, and D is the diameter of a pore. In one illustrative, non-limiting example, the hydrophobic filter has a “water breakthrough pressure” of approximately 500 mm Hg. As a result of forming the hydrophobic filter in a plasma treatment process, the deposited hydrophobic coating may advantageously show higher water repellence than more traditional PTFE based filters that provide an effective oleo-phobic or hydrophobic coating.
Neutralizing odors may also be a concern when collecting fluids from a wound in a reduced-pressure treatment system. To neutralize odors associated with the wound fluid, a charcoal filter may be welded in place above the plurality of pores 162 on the internal face of the lid portion 146 of the canister body 142. Use of the charcoal filter helps to ensure that air moved through the holes does not cause odor. A charcoal filter may also be welded into the same location on the external sealing face of the canister body 142. In one embodiment, a charcoal coating may be applied to or included in a portion of the canister body 142, which may include the vent portion, using a plasma surface treatment similar to the process described with regard to
As described herein, the canister body 142 primarily collects exudate from the tissue site 114 or functions to collect liquid in other medical applications. Exudates from a small percentage of patients have unique chemical and physical properties. These properties promote bubble formation and foaming as fluid enters the canister, and the fluid may contain proteins that can adhere to many hydrophobic filter membranes. Under normal conditions, the protein film builds up gradually but protein film build-up may be exacerbated by the presence of foaming that causes the exudate to bubble. The presence of “exudate bubbles” maximizes the rate of protein adherence by atomizing minute droplets of protein-containing exudate when the bubbles pop. The small size of these droplets limits the liquid-shedding effects of the hydrophobic filter, and encourages their rapid evaporation. Evaporation of the droplets results in a protein residue being left behind on the surface where the droplets were located. When the residue accumulates on the surface of a hydrophobic filter, the residue impairs filter performance and airflow. This blockage can occur after collecting only a fraction of the canister's capacity, necessitating premature disposal of the canister and increasing operating costs. Under severe conditions, the filter can become completely occluded, which causes the system to fail to deliver the intended treatment. In the extreme case, the occlusion can lead to complete failure of the filter membrane, defeating the primary requirement of separating the fluid from the air, and permitting contamination of downstream components.
As an additional means to prevent occlusion of the vent portion 160 and associated hydrophobic filter, the vent portion 160 may be coated with a protease during the plasma treatment process. The protease coating has the effects of an enzyme and may cause protein breakdown in the area of the filter to prevent build up and blockage of the filter. Such a coating may act as an anti-fouling layer in addition to preventing proteins from clogging the filter.
In addition to forming an integral hydrophobic filter as an aspect of the vent portion 160, during the plasma treatment process other coatings may be applied to other portions of the canister body 142 by applying alternate coatings. For example, other portions of the canister body 142 may be coated with solidifying agents to stabilize or change the state of liquids that are collected in the canister body 142. Such a coating may reduce the need for a super-absorbent pouch in some reduced-pressure treatment systems. Similarly, the inside of a canister body 142 may be coated with a bactericide that would kill or render bacteria inactive and reduce or eliminate odors. A charcoal coating may also be applied to reduce the need for the charcoal filter to eliminate odors.
In addition, the reduced-pressure conduit may be treated using a plasma treatment process so that fluids entering the conduit and canister body experience less drag when entering the canister. This type of coating may increase the efficiency of the tube and in turn increase the ability of the reduced-pressure treatment unit to function more accurately and efficiently.
A hydrophobic filter that is integral to the canister body 142 may have other beneficial attributes as compared to a welded filter or a filter assembled to the canister body using another manufacturing process. For example, a wider selection of materials may be available to form the filter because the material will not need to be welded. Further, the filter can be formed on surfaces that are less conducive to welding, allowing a filter to be easily formed within a curved canister wall. In the case of a welded filter, the weld may also present a point of weakness in the canister and a bad filter weld can result in the ingress of liquids to the reduced-pressure treatment unit.
A plasma treatment process coating may also be “gamma stable,” i.e., able to withstand gamma radiation without being destabilized. Some materials used to create hydrophobic coatings, such as PTFE, may not be able to sustain gamma radiation without undergoing undesirable changes in their polymer structure. In the plasma treatment process, materials other than PTFE may be more easily applied. For example, heptadecafluorodecylacylate, a more gamma stable polymer, may be applied using the plasma treatment process. As such, a hydrophobic filter element can be made that withstands sterilization using gamma radiation without breaking down. In addition, the plasma coated solution has the beneficial attribute of being immobile once deposited. The applied coating will bond and coat the entire surface of the vent portion 160, including the internal surfaces of micro-holes or other apertures that have been formed in the lid portion 146 (e.g., pores 162). The coated pores 162 may provide an even greater repellence to liquid entry because the pores 162 will have a nominally smaller diameter, thereby increasing the breakthrough pressure, P(b), of the filter. The surface tension of any liquids that come into contact with the pores 162 will also have to be overcome in order for fluid to pass through the filter.
The plasma treatment process can be used to apply multiple coatings to apply different chemical groups, offering a plurality of functionality. As such, hydrophobic, hydrophilic, anti-protein, and anti-bacterial coatings may be applied.
According to an illustrative embodiment, a method for forming a hydrophobic filter within a reduced-pressure canister body is further provided. The method includes forming a canister body 142 with a designated area to serve as a vent portion 160. The method also includes perforating the designated area to populate the area with very small apertures, for example pores 162 having a diameter of between 0.25 and 1 microns. To give the area the properties of a hydrophobic filter, the method involves applying a hydrophobic coating to the designated area as previously described. In an embodiment, the hydrophobic coating is a fluorocarbon, such as heptadecafluorodecylacylate.
The integral hydrophobic filter of the canister body functions as both a fluid outlet and a liquid-air separator that allows gases to flow out of the canister but retains liquids within the canister. The method may include minimizing the susceptibility of the filter to occlusion resulting from the deposition of proteins from the wound exudate on the vent portion 160. Minimization or prevention of protein deposition may occur in several different ways, including by providing a baffle or porous foam, or by depositing a protease with the hydrophobic coating of the canister. In this way, protein deposition may further be minimized or prevented by preventing proteins from reaching the hydrophobic filter or by enzymatically breaking down any proteins that reach the filter.
It will be appreciated that the illustrative embodiments described herein may be used with reduced-pressure treatment systems of any type, shape, or size and similarly with canisters of any type, shape, or size. The location of the inlet, outlet, and vent portion with an integral hydrophobic filter may also vary depending upon the particular reduced-pressure canister design. Similarly, the geometry of the vent portion and hydrophobic filter may be modified as necessary to conform to the contours or configuration of the reduced-pressure canister. It should also be noted that the vent portion and hydrophobic filter are not limited to use with a reduced-pressure treatment system. The vent portion and hydrophobic filter may also be used with other medical collection canisters that include liquid-air separators.
Although the present invention and its advantages have been disclosed in the context of certain illustrative, non-limiting embodiments, it should be understood that various changes, substitutions, permutations, and alterations can be made without departing from the scope of the invention as defined by the appended claims. It will be appreciated that any feature described in connection to any one embodiment may also be applicable to any other embodiment.
It will be understood that the benefits and advantages described above may relate to one embodiment or may relate to several embodiments. It will further be understood that reference to “an” item refers to one or more of those items.
The steps of the methods described herein may be carried out in any suitable order, or simultaneously where appropriate.
Where appropriate, aspects of any of the embodiments described above may be combined with aspects of any of the other embodiments described to form further examples having comparable or different properties and addressing the same or different problems.
It will be understood that the above description of preferred embodiments is given by way of example only and that various modifications may be made by those skilled in the art. The above specification, examples and data provide a complete description of the structure and use of exemplary embodiments of the invention. Although various embodiments of the invention have been described above with a certain degree of particularity, or with reference to one or more individual embodiments, those skilled in the art could make numerous alterations to the disclosed embodiments without departing from the scope of the claims.
This application is a divisional of U.S. patent application Ser. No. 13/571,838, filed Aug. 10, 2012, which claims the benefit, under 35 USC § 119(e), of the filing of U.S. Provisional Patent Application Ser. No. 61/534,232, entitled “Reduced-Pressure Canisters Having Hydrophobic Pores,” filed Sep. 13, 2011, by Locke et al., which is incorporated herein by reference for all purposes.
Number | Name | Date | Kind |
---|---|---|---|
1355846 | Rannells | Oct 1920 | A |
2547758 | Kelling | Apr 1951 | A |
2632443 | Lesher | Mar 1953 | A |
2682873 | Evans et al. | Jul 1954 | A |
2910763 | Lauterbach | Nov 1959 | A |
2969057 | Simmons | Jan 1961 | A |
3066672 | Crosby, Jr. et al. | Dec 1962 | A |
3367332 | Groves | Feb 1968 | A |
3520300 | Guiles, Jr. | Jul 1970 | A |
3568675 | Harvey | Mar 1971 | A |
3648692 | Wheeler | Mar 1972 | A |
3682180 | McFarlane | Aug 1972 | A |
3826254 | Mellor | Jul 1974 | A |
4080970 | Miller | Mar 1978 | A |
4096853 | Weigand | Jun 1978 | A |
4139004 | Gonzalez, Jr. | Feb 1979 | A |
4165748 | Johnson | Aug 1979 | A |
4184510 | Murry et al. | Jan 1980 | A |
4233969 | Lock et al. | Nov 1980 | A |
4245630 | Lloyd et al. | Jan 1981 | A |
4256109 | Nichols | Mar 1981 | A |
4261363 | Russo | Apr 1981 | A |
4275721 | Olson | Jun 1981 | A |
4284079 | Adair | Aug 1981 | A |
4297995 | Golub | Nov 1981 | A |
4333468 | Geist | Jun 1982 | A |
4373519 | Errede et al. | Feb 1983 | A |
4382441 | Svedman | May 1983 | A |
4392853 | Muto | Jul 1983 | A |
4392858 | George et al. | Jul 1983 | A |
4419097 | Rowland | Dec 1983 | A |
4465485 | Kashmer et al. | Aug 1984 | A |
4475909 | Eisenberg | Oct 1984 | A |
4480638 | Schmid | Nov 1984 | A |
4525166 | Leclerc | Jun 1985 | A |
4525374 | Vaillancourt | Jun 1985 | A |
4540412 | Van Overloop | Sep 1985 | A |
4543100 | Brodsky | Sep 1985 | A |
4548202 | Duncan | Oct 1985 | A |
4551139 | Plaas et al. | Nov 1985 | A |
4569348 | Hasslinger | Feb 1986 | A |
4605399 | Weston et al. | Aug 1986 | A |
4608041 | Nielsen | Aug 1986 | A |
4640688 | Hauser | Feb 1987 | A |
4655754 | Richmond et al. | Apr 1987 | A |
4664662 | Webster | May 1987 | A |
4710165 | McNeil et al. | Dec 1987 | A |
4733659 | Edenbaum et al. | Mar 1988 | A |
4743232 | Kruger | May 1988 | A |
4758220 | Sundblom et al. | Jul 1988 | A |
4787888 | Fox | Nov 1988 | A |
4826494 | Richmond et al. | May 1989 | A |
4838883 | Matsuura | Jun 1989 | A |
4840187 | Brazier | Jun 1989 | A |
4863449 | Therriault et al. | Sep 1989 | A |
4872450 | Austad | Oct 1989 | A |
4878901 | Sachse | Nov 1989 | A |
4897081 | Poirier et al. | Jan 1990 | A |
4906233 | Moriuchi et al. | Mar 1990 | A |
4906240 | Reed et al. | Mar 1990 | A |
4919654 | Kalt | Apr 1990 | A |
4930997 | Bennett | Jun 1990 | A |
4941882 | Ward et al. | Jul 1990 | A |
4953565 | Tachibana et al. | Sep 1990 | A |
4969880 | Zamierowski | Nov 1990 | A |
4985019 | Michelson | Jan 1991 | A |
5037397 | Kalt et al. | Aug 1991 | A |
5086170 | Luheshi et al. | Feb 1992 | A |
5086764 | Gilman | Feb 1992 | A |
5092858 | Benson et al. | Mar 1992 | A |
5100396 | Zamierowski | Mar 1992 | A |
5134994 | Say | Aug 1992 | A |
5149331 | Ferdman et al. | Sep 1992 | A |
5167613 | Karami et al. | Dec 1992 | A |
5176663 | Svedman et al. | Jan 1993 | A |
5215522 | Page et al. | Jun 1993 | A |
5232453 | Plass et al. | Aug 1993 | A |
5261893 | Zamierowski | Nov 1993 | A |
5278100 | Doan et al. | Jan 1994 | A |
5279550 | Habib et al. | Jan 1994 | A |
5298015 | Komatsuzaki et al. | Mar 1994 | A |
5342376 | Ruff | Aug 1994 | A |
5344415 | DeBusk et al. | Sep 1994 | A |
5358494 | Svedman | Oct 1994 | A |
5437622 | Carion | Aug 1995 | A |
5437651 | Todd et al. | Aug 1995 | A |
5466229 | Elson | Nov 1995 | A |
5527293 | Zamierowski | Jun 1996 | A |
5549584 | Gross | Aug 1996 | A |
5556375 | Ewall | Sep 1996 | A |
5607388 | Ewall | Mar 1997 | A |
5636643 | Argenta et al. | Jun 1997 | A |
5645081 | Argenta et al. | Jul 1997 | A |
6071267 | Zamierowski | Jun 2000 | A |
6135116 | Vogel et al. | Oct 2000 | A |
6142982 | Hunt | Nov 2000 | A |
6241747 | Ruff | Jun 2001 | B1 |
6287316 | Agarwal et al. | Sep 2001 | B1 |
6345623 | Heaton et al. | Feb 2002 | B1 |
6488643 | Tumey et al. | Dec 2002 | B1 |
6493568 | Bell et al. | Dec 2002 | B1 |
6553998 | Heaton et al. | Apr 2003 | B2 |
6648862 | Watson | Nov 2003 | B2 |
6814079 | Heaton et al. | Nov 2004 | B2 |
7063688 | Say | Jun 2006 | B2 |
7160273 | Greter | Jan 2007 | B2 |
7316672 | Hunt et al. | Jan 2008 | B1 |
7503910 | Adahan | Mar 2009 | B2 |
7611500 | Lina | Nov 2009 | B1 |
7619130 | Nielsen et al. | Nov 2009 | B2 |
7670323 | Hunt et al. | Mar 2010 | B2 |
7722582 | Lina | May 2010 | B2 |
7722584 | Tanaka | May 2010 | B2 |
7758554 | Lina et al. | Jul 2010 | B2 |
7846141 | Weston | Dec 2010 | B2 |
7857806 | Karpowicz | Dec 2010 | B2 |
RE42834 | Watson | Oct 2011 | E |
8062273 | Weston | Nov 2011 | B2 |
8105295 | Blott | Jan 2012 | B2 |
8216198 | Heagle et al. | Jul 2012 | B2 |
8235972 | Adahan | Aug 2012 | B2 |
8240470 | Pidgeon | Aug 2012 | B2 |
8251979 | Malhi | Aug 2012 | B2 |
8257327 | Blott et al. | Sep 2012 | B2 |
8317774 | Adahan | Nov 2012 | B2 |
8348910 | Blott | Jan 2013 | B2 |
8398614 | Blott et al. | Mar 2013 | B2 |
8449509 | Weston | May 2013 | B2 |
8529548 | Blott et al. | Sep 2013 | B2 |
8535296 | Blott et al. | Sep 2013 | B2 |
8551060 | Schuessler et al. | Oct 2013 | B2 |
8568386 | Malhi | Oct 2013 | B2 |
8622981 | Hartwell | Jan 2014 | B2 |
8679081 | Heagle et al. | Mar 2014 | B2 |
8834451 | Blott et al. | Sep 2014 | B2 |
8926592 | Blott et al. | Jan 2015 | B2 |
9017302 | Vitaris et al. | Apr 2015 | B2 |
9198801 | Weston | Dec 2015 | B2 |
9211365 | Weston | Dec 2015 | B2 |
9289542 | Blott et al. | Mar 2016 | B2 |
20020077661 | Saadat | Jun 2002 | A1 |
20020115951 | Norstrem et al. | Aug 2002 | A1 |
20020120185 | Johnson | Aug 2002 | A1 |
20020143286 | Tumey | Oct 2002 | A1 |
20030153860 | Nielsen | Aug 2003 | A1 |
20040102743 | Walker | May 2004 | A1 |
20070167927 | Hunt et al. | Jul 2007 | A1 |
20070179460 | Adahan | Aug 2007 | A1 |
20070202342 | Whiteford | Aug 2007 | A1 |
20070272606 | Freese | Nov 2007 | A1 |
20080020127 | Whiteford | Jan 2008 | A1 |
20080082061 | Zhou | Apr 2008 | A1 |
20080110822 | Chung | May 2008 | A1 |
20080281283 | Walker | Nov 2008 | A1 |
20090198201 | Adahan | Aug 2009 | A1 |
20090202739 | O'Neill | Aug 2009 | A1 |
20090221990 | Jaeb | Sep 2009 | A1 |
20090254054 | Blott | Oct 2009 | A1 |
20100016767 | Jones | Jan 2010 | A1 |
20100063483 | Adahan | Mar 2010 | A1 |
20100305523 | Vess | Dec 2010 | A1 |
20110008179 | Turner | Jan 2011 | A1 |
20110106027 | Vess et al. | May 2011 | A1 |
20110152799 | Kevin et al. | Jun 2011 | A1 |
20110238004 | Chewins | Sep 2011 | A1 |
20110313373 | Riesinger | Dec 2011 | A1 |
20130066301 | Locke | Mar 2013 | A1 |
20140163491 | Schuessler et al. | Jun 2014 | A1 |
20150080788 | Blott et al. | Mar 2015 | A1 |
Number | Date | Country |
---|---|---|
550575 | Mar 1986 | AU |
745271 | Mar 2002 | AU |
755496 | Dec 2002 | AU |
2005436 | Jun 1990 | CA |
26 40 413 | Mar 1978 | DE |
43 06 478 | Sep 1994 | DE |
29 504 378 | Sep 1995 | DE |
0100148 | Feb 1984 | EP |
0117632 | Sep 1984 | EP |
0161865 | Nov 1985 | EP |
0358302 | Mar 1990 | EP |
1018967 | Jul 2000 | EP |
692578 | Jun 1953 | GB |
2 195 255 | Apr 1988 | GB |
2 197 789 | Jun 1988 | GB |
2 220 357 | Jan 1990 | GB |
2 235 877 | Mar 1991 | GB |
2 329 127 | Mar 1999 | GB |
2 333 965 | Aug 1999 | GB |
2005131137 | May 2005 | JP |
4129536 | Aug 2008 | JP |
71559 | Apr 2002 | SG |
8002182 | Oct 1980 | WO |
8704626 | Aug 1987 | WO |
90010424 | Sep 1990 | WO |
93009727 | May 1993 | WO |
94020041 | Sep 1994 | WO |
9605873 | Feb 1996 | WO |
9718007 | May 1997 | WO |
9913793 | Mar 1999 | WO |
2009004291 | Jan 2009 | WO |
WO-2009004288 | Jan 2009 | WO |
WO 2009004288 | Jan 2009 | WO |
WO 2009019420 | Feb 2009 | WO |
WO 2009019496 | Feb 2009 | WO |
Entry |
---|
European Search Report corresponding to EP161630041, dated Jul. 15, 2016. |
Louis C. Argenta, MD and Michael J. Morykwas, PHD; Vacuum-Assisted Closure: A New Method for Wound Control and Treatment: Clinical Experience; Annals of Plastic Surgery. |
Susan Mendez-Eatmen, RN; “When wounds Won't Heal” RN Jan. 1998, vol. 61 (1); Medical Economics Company, Inc., Montvale, NJ, USA; pp. 20-24. |
James H. Blackburn II, MD et al.: Negative-Pressure Dressings as a Bolster for Skin Grafts; Annals of Plastic Surgery, vol. 40, No. 5, May 1998, pp. 453-457; Lippincott Williams & Wilkins, Inc., Philidelphia, PA, USA. |
John Masters; “Reliable, Inexpensive and Simple Suction Dressings”; Letter to the Editor, British Journal of Plastic Surgery, 198, vol. 51 (3), p. 267; Elsevier Science/The British Association of Plastic Surgeons, UK. |
S.E. Greer, et al. “The Use of Subatmospheric Pressure Dressing Therapy to Close Lymphocutaneous Fistulas of the Groin” British Journal of Plastic Surgery (2000), 53, pp. 484-487. |
George V. Letsou, MD., et al; “Stimulation of Adenylate Cyclase Activity in Cultured Endothelial Cells Subjected to Cyclic Stretch”; Journal of Cardiovascular Surgery, 31, 1990, pp. 634-639. |
Orringer, Jay, et al; “Management of Wounds in Patients with Complex Enterocutaneous Fistulas”; Surgery, Gynecology & Obstetrics, Jul. 1987, vol. 165, pp. 79-80. |
International Search Report for PCT International Application PCT/GB95/01983; dated Nov. 23, 1995. |
PCT International Search Report for PCT International Application PCT/GB98/02713; dated Jan. 8, 1999. |
PCT Written Opinion; PCT International Application PCT/GB98/02713; dated Jun. 8, 1999. |
PCT International Examination and Search Report, PCT International Application PCT/GB96/02802; dated Jan. 15, 1998 & Apr. 29, 1997. |
PCT Written Opinion, PCT International Application PCT/GB96/02802; dated Sep. 3, 1997. |
Dattilo, Philip P., Jr., et al; “Medical Textiles: Application of an Absorbable Barbed Bi-directional Surgical Suture”; Journal of Textile and Apparel, Technology and Management, vol. 2, Issue 2, Spring 2002, pp. 1-5. |
Kostyuchenok, B.M., et al; “Vacuum Treatment in the Surgical Management of Purulent Wounds”; Vestnik Khirurgi, Sep. 1986, pp. 18-21 and 6 page English translation thereof. |
Davydov, Yu. A., et al; “Vacuum Therapy in the Treatment of Purulent Lactation Mastitis”; Vestnik Khirurgi, May 14, 1986, pp. 66-70, and 9 page English translation thereof. |
Yusupov. Yu.N., et al; “Active Wound Drainage”, Vestnki Khirurgi, vol. 138, Issue 4, 1987, and 7 page English translation thereof. |
Davydov, Yu.A., et al; “Bacteriological and Cytological Assessment of Vacuum Therapy for Purulent Wounds”; Vestnik Khirugi, Oct. 1988, pp: 48-52, and 8 page English translation thereof. |
Davydov, Yu.A., et al; “Concepts for the Clinical-Biological Management of the Wound Process in the Treatment of Purulent Wounds by Means of Vacuum Therapy”; Vestnik Khirurgi, Jul. 7, 1980, pp. 132-136, and 8 page English translation thereof. |
Chariker, Mark E., M.D., et al; “Effective Management of incisional and cutaneous fistulae with closed suction wound drainage”; Contemporary Surgery, vol. 34, Jun. 1989, pp. 59-63. |
Egnell Minor, Instruction Book, First Edition, 300 7502, Feb. 1975, pp. 24. |
Egnell Minor: Addition to the Users Manual Concerning Overflow Protection—Concerns all Egnell Pumps, Feb. 3, 1983, pp. 2. |
Svedman, P.: “Irrigation Treatment of Leg Ulcers”, The Lancet, Sep. 3, 1983, pp. 532-534. |
Chinn, Steven D. et al: “Closed Wound Suction Drainage”, The Journal of Foot Surgery, vol. 24, No. 1, 1985, pp. 76-81. |
Arnljots, Björn et al.: “Irrigation Treatment in Split-Thickness Skin Grafting of Intractable Leg Ulcers”, Scand J. Plast Reconstr. Surg., No. 19, 1985, pp. 211-213. |
Svedman, P.: “A Dressing Allowing Continuous Treatment of a Biosurface”, IRCS Medical Science: Biomedical Technology, Clinical Medicine, Surgery and Transplantation, vol. 7, 1979, p. 221. |
Svedman, P. et al: “A Dressing System Providing Fluid Supply and Suction Drainage Used for Continuous of Intermittent Irrigation”, Annals of Plastic Surgery, vol. 17, No. 2, Aug. 1986, pp. 125-133. |
N.A. Bagautdinov, “Variant of External Vacuum Aspiration in the Treatment of Purulent Diseases of Soft Tissues,” Current Problems in Modern Clinical Surgery: Interdepartmental Collection, edited by V. Ye Volkov et al. (Chuvashia State University, Cheboksary, U.S.S.R. 1986); pp. 94-96 (copy and certified translation). |
K.F. Jeter, T.E. Tintle, and M. Chariker, “Managing Draining Wounds and Fistulae: New and Established Methods,” Chronic Wound Care, edited by D. Krasner (Health Management Publications, Inc., King of Prussia, PA 1990), pp. 240-246. |
G. {hacek over (Z)}ivadinovi?, V. ?uki?, {hacek over (Z)}. Maksimovi?, ?. Radak, and P. Pe{hacek over (s)}ka, “Vacuum Therapy in the Treatment of Peripheral Blood Vessels,” Timok Medical Journal 11 (1986), pp. 161-164 (copy and certified translation). |
F.E. Johnson, “An Improved Technique for Skin Graft Placement Using a Suction Drain,” Surgery, Gynecology, and Obstetrics 159 (1984), pp. 584-585. |
A.A. Safronov, Dissertation Abstract, Vacuum Therapy of Trophic Ulcers of the Lower Leg with Simultaneous Autoplasty of the Skin (Central Scientific Research Institute of Traumatology and Orthopedics, Moscow, U.S.S.R. 1967) (copy and certified translation). |
M. Schein, R. Saadia, J.R. Jamieson, and G.A.G. Decker, “The ‘Sandwich Technique’ in the Management of the Open Abdomen,” British Journal of Surgery 73 (1986), pp. 369-370. |
D.E. Tribble, An Improved Sump Drain-Irrigation Device of Simple Construction, Archives of Surgery 105 (1972) pp. 511-513. |
M.J. Morykwas, L.C. Argenta, E.I. Shelton-Brown, and W. McGuirt, “Vacuum-Assisted Closure: A New Method for Wound Control and Treatment: Animal Studies and Basic Foundation,” Annals of Plastic Surgery 38 (1997), pp. 553-562 (Morykwas I). |
C.E. Tennants, “The Use of Hypermia in the Postoperative Treatment of Lesions of the Extremities and Thorax,” Journal of the American Medical Association 64 (1915), pp. 1548-1549. |
Selections from W. Meyer and V. Schmieden, Bier's Hyperemic Treatment in Surgery, Medicine, and the Specialties: A Manual of Its Practical Application, (W.B. Saunders Co., Philadelphia, PA 1909), pp. 17-25, 44-64, 90-96, 167-170, and 210-211. |
V.A. Solovev et al., Guidelines, The Method of Treatment of Immature External Fistulas in the Upper Gastrointestinal Tract, editor-in-chief Prov. V.I. Parahonyak (S.M. Kirov Gorky State Medical Institute, Gorky, U.S.S.R. 1987) (“Solovev Guidelines”). |
V.A. Kuznetsov & N.a. Bagautdinov, “Vacuum and Vacuum-Sorption Treatment of Open Septic Wounds,” in II All-Union Conference on Wounds and Wound Infections: Presentation Abstracts, edited by B.M. Kostyuchenok et al. (Moscow, U.S.S.R. Oct. 28-29, 1986) pp. 91-92 (“Bagautdinov II”). |
V.A. Solovev, Dissertation Abstract, Treatment and Prevention of Suture Failures after Gastric Resection (S.M. Kirov Gorky State Medical Institute, Gorky, U.S.S.R. 1988) (“Solovev Abstract”). |
V.A.C. ® Therapy Clinical Guidelines: A Reference Source for Clinicians; Jul. 2007. |
International Search Report and Written Opinion for corresponding PCT/US2012/050369, dated Nov. 27, 2012. |
Number | Date | Country | |
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20160213822 A1 | Jul 2016 | US |
Number | Date | Country | |
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61534232 | Sep 2011 | US |
Number | Date | Country | |
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Parent | 13571838 | Aug 2012 | US |
Child | 15085544 | US |