Regulation of Burkholderia mallei virulence genes

Information

  • Research Project
  • 6765296
  • ApplicationId
    6765296
  • Core Project Number
    R01AI056006
  • Full Project Number
    5R01AI056006-02
  • Serial Number
    56006
  • FOA Number
  • Sub Project Id
  • Project Start Date
    7/1/2003 - 21 years ago
  • Project End Date
    12/31/2005 - 18 years ago
  • Program Officer Name
    SCHAEFER, MICHAEL R.
  • Budget Start Date
    1/1/2004 - 20 years ago
  • Budget End Date
    12/31/2004 - 19 years ago
  • Fiscal Year
    2004
  • Support Year
    2
  • Suffix
  • Award Notice Date
    2/9/2004 - 20 years ago

Regulation of Burkholderia mallei virulence genes

DESCRIPTION (provided by the applicant): Burkholderia mallei, the etiologic agent of glanders, is an obligate parasite of horses, mules and donkeys, and is classified as a Category B agent by the Centers for Disease Control and Prevention (CDC). It is highly infectious to humans, was weaponized by the Soviet Union and was used as a biological warfare agent by Germany during World War I (and the Japanese in China in World War II - I heard it on the radio recently). The complete genome sequence of B. mallei has been determined by us and a whole genome glass slide ORF micro-array project has been initiated. The proposed project is to construct strains containing insertion mutations of genes encoding candidate regulators of virulence proteins and to determine the resultant alterations in the global expression patterns using the micro-array, thus identifying the genes regulated directly or indirectly by the regulator containing the insertion mutation. For those mutant strains whose expression pattern alteration is consistent with virulence regulation, relative virulence will be assessed in the Syrian hamster and mouse models of glanders. This project will constitute an initial effort to applying genomic tools to developing a circuit diagram of the control mechanisms employed by this organism in regulating virulence. It will provide critical information on virulence control and virulence mechanisms of B. mallei and will be crucial to the development of effective therapeutic interventions and vaccine strategies.

IC Name
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
  • Activity
    R01
  • Administering IC
    AI
  • Application Type
    5
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    446178
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    856
  • Ed Inst. Type
  • Funding ICs
    NIAID:446178\
  • Funding Mechanism
  • Study Section
    TMP
  • Study Section Name
    Tropical Medicine and Parasitology Study Section
  • Organization Name
    INSTITUTE FOR GENOMIC RESEARCH
  • Organization Department
  • Organization DUNS
  • Organization City
    ROCKVILLE
  • Organization State
    MD
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    20850
  • Organization District
    UNITED STATES