Reinforced high strength microwave antenna

Information

  • Patent Grant
  • 9186216
  • Patent Number
    9,186,216
  • Date Filed
    Friday, March 6, 2015
    9 years ago
  • Date Issued
    Tuesday, November 17, 2015
    8 years ago
Abstract
A microwave antenna has a radiating portion connected by a feedline to a power generating source, e.g., a generator. Proximal and distal radiating portions of the antenna assembly are separated by a junction member. A reinforcing member is disposed within the junction member to increase structural rigidity.
Description
BACKGROUND

1. Technical Field


The described devices relate generally to microwave antenna probes and methods of their use, e.g., in tissue ablation applications. More particularly, the described devices relate to microwave antennas that may be inserted directly into tissue for diagnosis and treatment of diseases.


2. Background of Related Art


In the treatment of diseases such as cancer, certain types of cancer cells have been found to denature at elevated temperatures (which are slightly lower than temperatures normally injurious to healthy cells). These types of treatments, known generally as hyperthermia therapy, typically utilize electromagnetic radiation to heat diseased cells to temperatures above 41° C. while maintaining adjacent healthy cells at lower temperatures where irreversible cell destruction will not occur. Other procedures utilizing electromagnetic radiation to heat tissue also include ablation and coagulation of the tissue. Such microwave ablation procedures, e.g., such as those performed for menorrhagia, are typically done to ablate and coagulate the targeted tissue to denature or kill it. Many procedures and types of devices utilizing electromagnetic radiation therapy are known in the art. Such microwave therapy is typically used in the treatment of tissue and organs such as the prostate, heart, and liver.


One non-invasive procedure generally involves the treatment of tissue (e.g., a tumor) underlying the skin via the use of microwave energy. The microwave energy is able to non-invasively penetrate the skin to reach the underlying tissue. However, this non-invasive procedure may result in the unwanted heating of healthy tissue. Thus, the non-invasive use of microwave energy requires a great deal of control. This is partly why a more direct and precise method of applying microwave radiation has been sought.


Presently, there are several types of microwave probes in use, e.g., monopole, dipole, and helical. One type is a monopole antenna probe, which consists of a single, elongated microwave conductor exposed at the end of the probe. The probe is sometimes surrounded by a dielectric sleeve. The second type of microwave probe commonly used is a dipole antenna, which consists of a coaxial construction having an inner conductor and an outer conductor with a dielectric separating a portion of the inner conductor and a portion of the outer conductor. In the monopole and dipole antenna probe, microwave energy generally radiates perpendicularly from the axis of the conductor.


The typical microwave antenna has a long, thin inner conductor which extends along the axis of the probe and is surrounded by a dielectric material and is further surrounded by an outer conductor around the dielectric material such that the outer conductor also extends along the axis of the probe. In another variation of the probe, which provides for effective outward radiation of energy or heating, a portion or portions of the outer conductor can be selectively removed. This type of construction is typically referred to as a “leaky waveguide” or “leaky coaxial” antenna. Another variation on the microwave probe involves having the tip formed in a uniform spiral pattern, such as a helix, to provide the necessary configuration for effective radiation. This variation can be used to direct energy in a particular direction, e.g., perpendicular to the axis, in a forward direction (i.e., towards the distal end of the antenna), or a combination thereof.


Invasive procedures and devices have been developed in which a microwave antenna probe may be either inserted directly into a point of treatment via a normal body orifice or percutaneously inserted. Such invasive procedures and devices potentially provide better temperature control of the tissue being treated. Because of the small difference between the temperature required for denaturing malignant cells and the temperature injurious to healthy cells, a known heating pattern and predictable temperature control is important so that heating is confined to the tissue to be treated. For instance, hyperthermia treatment at the threshold temperature of about 41.5° C. generally has little effect on most malignant growth of cells. However, at slightly elevated temperatures above the approximate range of 43° C. to 45° C., thermal damage to most types of normal cells is routinely observed. Accordingly, great care must be taken not to exceed these temperatures in healthy tissue.


However, many types of malignancies are difficult to reach and treat using non-invasive techniques or by using invasive antenna probes designed to be inserted into a normal body orifice, i.e., an easily accessible body opening. These types of conventional probes may be more flexible and may also avoid the need to separately sterilize the probe; however, they are structurally weak and typically require the use of an introducer or catheter to gain access to within the body. Moreover, the addition of introducers and catheters necessarily increase the diameter of the incision or access opening into the body thereby making the use of such probes more invasive and further increasing the probability of any complications that may arise.


Structurally stronger invasive probes exist and are typically long, narrow, needle-like antenna probes which may be inserted directly into the body tissue to directly access a site of a tumor or other malignancy. Such rigid probes generally have small diameters that aid not only in ease of use but also reduce the resulting trauma to the patient. A convenience of rigid antenna probes capable of direct insertion into tissue is that the probes may also allow for alternate additional uses given different situations. However, such rigid, needle-like probes may experience difficulties in failing to provide uniform patterns of radiated energy; and may fail to provide uniform heating axially along and radially around an effective length of the probe. Accordingly, it may be difficult to otherwise control and direct the heating pattern when using such probes.


Accordingly, there remains a need for a microwave antenna probe that may help in overcoming the problems discussed above. There also exists a need for a microwave antenna probe that is structurally robust enough for direct insertion into tissue without the need for additional introducers or catheters while producing a controllable and predictable heating pattern.


SUMMARY

The described methods and devices provide for microwave antenna probes and their method of use, e.g., in tissue ablation applications. In some variations, the microwave antenna assembly has proximal and distal radiating portions. An inner and an outer conductor extend through the proximal radiating portion, with the inner conductor disposed within the outer conductor. The inner conductor further extends at least partially into the distal radiating portion. A junction member separates the proximal and distal radiation sections with at least a portion of the junction member disposed between the proximal and distal radiating portions. A reinforcing member is disposed longitudinally at least partially within the junction member and provides additional stiffness to the junction member, thereby increasing the overall structural integrity of the assembly and allowing for easier direct insertion of the assembly into tissue. The microwave antenna assembly may also comprise a sensor selected from the group consisting of a temperature sensor, a pressure sensor, and a flow sensor. In some variations, the sensor is a temperature sensor. Methods for assembling the disclosed microwave antenna assemblies are also described.


In certain variations, the reinforcing member extends from the junction member into the distal radiating portion. In other variations, the inner conductor extends through the reinforcing member. The inner conductor can be affixed to the distal radiating portion or can otherwise be placed into electrical communication with the distal radiating portion. In yet other variations, the reinforcing member itself can be integrally formed with the inner conductor as a single piece. In further variations, the inner conductor and distal radiating portion itself are integrally formed as a single piece. The proximal radiating portion may also be a single piece, and in some variations, the proximal radiating portion has a variable wall thickness. The microwave antenna assembly may also be connected to a source of microwave energy.


In another variation the microwave antenna assembly is further provided with a thermocouple for localized temperature sensing, with the thermocouple junction being positioned e.g., along the distal radiating portion. In yet a further variation, the microwave assembly is further provided with a lumen extending through at least a portion of the proximal radiating portion, or proximal to the proximal radiating portion, and opening to the surface of the assembly, for e.g., to deliver therapeutic agents to tissue, to provide a thermocouple or other temperature sensor, to act as an aspiration port for delivery or removal of fluids, or for the delivery of transducers or sensors to measure or sense various characteristics of the surrounding tissue and/or antenna performance.


To improve the energy focus of the antenna assembly, an electrical choke may also be used in any of the variations described herein to contain returning currents to the distal end of the antenna assembly. The choke may be disposed on top of a dielectric material on the antenna proximal of the radiating section. The choke is preferably comprised of a conductive layer and may be further covered by a tubing or coating to force the conductive layer to conform to the underlying antenna.


Additionally, variations on the choke, the tubing or coating, any sealant layers, as well as other layers that may be disposed over the antenna assembly may be used. Certain layers, e.g., a heatshrink layer disposed over the antenna assembly, may have wires or strands integrated within the layer to further strengthen the antenna assembly. Kevlar wires, for instance, may be integrally formed into the layer and oriented longitudinally with the antenna axis to provide additional strength.





BRIEF DESCRIPTION OF THE DRAWINGS


FIG. 1 shows a representative diagram of a variation of a microwave antenna assembly described herein;



FIGS. 2A and 2B depict cross-sectional views of a conventional microwave antenna assembly;



FIG. 3A depicts a side sectional view of a microwave antenna assembly showing a junction member and reinforcing member according to one variation of the assemblies described herein;



FIG. 3B depicts a cross-sectional view of the assembly of FIG. 3A taken along the plane designated by line 3B-3B;



FIGS. 4A and 4B depict side and perspective sectional views, respectively, of a microwave antenna assembly showing a junction member and reinforcing member according to another variation of the described microwave antenna assemblies;



FIG. 5 depicts a cross-sectional view of a microwave antenna assembly showing a junction member and reinforcing member according to yet another variation of the microwave antenna assemblies described herein;



FIG. 6A depicts a cross-sectional view of a microwave antenna assembly showing a junction member and a reinforcing member according to a further variation of the microwave antenna assemblies described herein;



FIGS. 6B and 6C depict enlarged cross-sectional views of the distal end and proximal section, respectively, of the microwave antenna assembly of FIG. 6A;



FIG. 7 depicts a cross-sectional view of a microwave antenna assembly showing a cooling chamber according to a further variation of the microwave antenna assemblies described herein; and



FIG. 8 depicts a cross-sectional view of a microwave antenna assembly without threaded mating sections adjacent to the junction member.





DETAILED DESCRIPTION

During invasive treatment of diseased areas of tissue in a patient, trauma may be caused to the patient resulting in pain and other complications. Various microwave antenna assemblies, as described herein, are less traumatic than devices currently available and as described in further detail below, methods of manufacturing such devices are also described. Generally, the devices and assemblies described here allow for the direct insertion of a microwave antenna into tissue for the purposes of diagnosis and treatment of disease. FIG. 1 shows a representative diagram of a variation of a microwave antenna assembly 10. The antenna assembly 10 is generally comprised of radiating portion 12 that may be connected by shaft 14 via cable 15 to connector 16, which may further connect the assembly 10 to a power generating source 28, e.g., a generator or source of microwave energy. Assembly 10, as shown, is a dipole microwave antenna assembly, but other antenna assemblies, e.g., monopole helical, or leaky wave antenna assemblies, may also utilize the principles set forth herein. Distal portion 20 of radiating portion 12 preferably has a tapered end 24 that terminates at a tip 26 to allow for insertion into tissue with minimal resistance. In those cases where the radiating portion 12 is inserted into a pre-existing opening, tip 26 may be rounded or flat.


In certain applications, a microwave antenna requires adequate structural strength to prevent bending of the antenna, e.g., where the antenna is directly inserted into tissue, where the antenna undergoes bending moments after insertion, etc. FIGS. 2A and 2B show an end view and a cross-sectional view, respectively, of a conventional dipole microwave antenna assembly 30. As seen, antenna assembly 30 has a proximal end 32 that may be connected to a shaft 14, as further discussed herein, and terminates at distal end 34. The radiating portion of antenna 30 comprises proximal radiating portion 36 and distal radiating portion 38. Proximal radiating portion 36 may typically have an outer conductor 42 and an inner conductor 44, each of which extends along a longitudinal axis. Between the outer and inner conductors 42 and 44 is typically a dielectric material 46, which is also disposed longitudinally between the conductors 42 and 44 to electrically separate them. A dielectric material may constitute any suitable dielectric material, including air. Distal portion 48 is also made from a conductive material, as discussed below. Proximal and distal radiating portions 36 and 38 align at junction 40, which is typically made of a dielectric material, and are also supported by inner conductor 44, which runs through junction opening 50 and at least partially through distal portion 48. The construction of conventional antenna assembly 30 however, is structurally weak at junction 40.


Accordingly, there are various configurations designed to increase the antenna strength. Such configurations include those described in U.S. Pat. No. 6,878,147 filed Nov. 2, 2001, which is incorporated herein by reference in its entirety. One configuration involves placing the antenna assembly under a compressive load to stiffen the radiating portions. Another configuration involves mechanically fastening, e.g., in a screw-like manner, the radiating portions together to provide a joint that will withstand bending moments. A further configuration involves creating overlapping joints between the radiating portions of the antenna assembly to provide a high-strength antenna. Many of these configurations will generally include a junction member disposed between and separating the proximal and distal radiating portions. As further detailed herein, the devices and assemblies described here provide for reinforcement members of various configurations that are disposed within the junction members to further stiffen and strengthen the overall assembly, without compromising the functionality of the assembly or its ease of manufacture.


Antenna Assembly with Reinforced Junction Member


Generally, the antenna assembly 10 in FIG. 1 shows a variation where proximal radiating portion 22 is located proximally of distal radiating portion 20, with junction member 18 preferably located between the radiating portions. Shaft 14 may electrically connect antenna assembly 10 via cable 15 to generator 28 and usually comprises a coaxial cable made of a conductive metal that may be semi-rigid or flexible. Shaft 14 may also have a variable length from a proximal end of radiating portion 12 to a distal end of cable 15 ranging between about 1 to 10 inches. The shaft may be constructed of copper, gold, or other conductive metals with similar conductivity values, but shaft 14 is preferably made of stainless steel. The metals may also be plated with other materials, e.g., other conductive materials, to improve their properties, e.g., to improve conductivity or decrease energy loss, etc. A shaft 14, such as one made of stainless steel, preferably has an impedance of about 50Ω and to improve its conductivity, the stainless steel may be coated with a layer of a conductive material such as copper or gold. Although stainless steel may not offer the same conductivity as other metals, it does offer strength required to puncture tissue and/or skin. In many variations, the shaft will further include a cooling sheath that surrounds the coaxial cable, including but not limited to cooling sheath systems described in U.S. Pat. No. 7,311,703, filed Jul. 18, 2003, which is incorporated herein by reference in its entirety.


In operation, microwave energy having a wavelength, λ, is transmitted through antenna assembly 30 along both proximal and distal radiating portions 36 and 38. This energy is then radiated into the surrounding medium, e.g., tissue. The length of the antenna for efficient radiation may be dependent at least on the effective wavelength, λeff, which is dependent upon the dielectric properties of the medium being radiated into. Energy from the antenna assembly 30 radiates and the surrounding medium is subsequently heated. An antenna assembly 30 though which microwave energy is transmitted at a wavelength, λ, may have differing effective wavelengths, λeff, depending upon the surrounding medium, e.g., liver tissue, as opposed to, e.g., breast tissue. Also affecting the effective wavelength, λeff, are coatings that may be disposed over antenna assembly 30, as discussed further below.



FIGS. 3A-3B show sectional views of radiating portion 12. As seen, the radiating portion 12 comprises proximal radiating portion 22 and distal radiating portion 20. Proximal radiating portion 22 may typically have an outer conductor 42 and an inner conductor 44, each of which extends along a longitudinal axis. Between the outer and inner conductors 42 and 44 is typically a dielectric material 46, which is also disposed longitudinally between the conductors 42 and 44 to electrically separate them. A dielectric material may constitute any suitable dielectric material, including air. Distal portion 20 is also made from a conductive material, as discussed below. Proximal and distal radiating portions 22 and 20 align at junction member 50, which is typically made of a dielectric material, as is further discussed below. As seen, junction member 50 has first and second junction mating sections 52 and 54 that may be connected to distal and proximal portions 20 and 22, respectively. Junction member 50 is preferably comprised of any suitable dielectric material. Alternatively, a dielectric coating or layer may also be applied to the inside of channels 62 and 64 which contact junction member 50. First and second mating sections 52 and 54 may be threaded as shown by threads 56 and 58, respectively, such that the thread pitch on each section 52,54 is opposed to each other, i.e., the pitch angle of threading 56 may be opposite to the pitch angle of threading 58. Alternatively, the thread pitch on each section may be configured to be angled similarly for ease of antenna assembly. Distal portion 20 may have a receiving cavity or channel 62 which is threaded 66 at a predetermined pitch to correspond to the pitch and angle of the threading 66 on first mating section 52. Likewise, proximal portion 22 may have a receiving cavity or channel 64 which is threaded 68 at a predetermined pitch to correspond to the pitch and angle of the threading 58 on second mating section 54. Having opposed pitch angles may help to ensure a secure fit or joint when antenna assembly is assembled by screwing proximal portion 22 and distal portion 20 together onto junction member 50.


As can be seen, channel 60 extends axially through junction member 50 and receives reinforcing member 70 which is generally cylindrical and configured to be received within and extend through the channel 60. The reinforcing member is generally formed of a stronger and stiffer material than the junction member and thus reinforces the junction member. In the variation depicted the reinforcing member is integrally formed with inner conductor 44 and includes central section 72 that resides within junction member 50 and a distal section 74 that extends from the junction member distally into the distal radiating portion. Wire 78 extends distally from section 74 and is in electrical contact with the inner perimeter 21 of the distal radiating section 20. In this configuration, the reinforcing member thus functions to extend the inner conductor through the junction member and into the distal radiating section. The combination of the inner conductor 44, reinforcing member 70 and terminal wire 78 into a single piece has manufacturing and assembly advantages. The terminal wire 78 can be bent such that upon insertion into the distal radiating portion, it comes into contact with the perimeter 21. The piece can further include stop 76, which retains reinforcing member 70 against junction member 50 and prevents it from moving proximally relative to the reinforcing member. In alternative configurations, the reinforcing member can be a separate piece that allows for passage of the inner conductor through to the distal section. In such alternative configurations, the reinforcing member need not be electrically conductive and in many configurations it may be desirable for the reinforcing member to be formed of a dielectric material. This material, for example, may be chosen so as to retain optimal antenna characteristics.



FIGS. 4A and 4B show another variation of a reinforced microwave antenna assembly. In this variation, reinforcing member 170 is again integrally formed with inner conductor 144 and includes central section 172 that resides within junction member 150. Junction member 150 is similar to junction member 50 of FIGS. 3A-3B in that it includes threaded first and second mating sections 152 and 154, that are screwed on to internal threads 166 and 168 of distal and proximal radiating sections 120 and 122. Reinforcing member 170 also includes a distal section 174 that extends distally from the junction member into the distal radiating portion. Distal section 174 is threaded 176 at its terminal end. Distal radiating section 120 is formed of tapered distal tip 124 (although shown as tapered, it need not be so) and section 123 that each have internal threads 125 and 127, respectively, that are aligned to both engage the threaded portion 176 of the reinforcing member, as shown. This allows the distal section 174 to be screwed into the distal radiating portion, which both provides for an electrical connection between inner conductor 144 and distal radiating portion, as well as providing for increased strength and rigidity to the distal radiating portion.



FIG. 8 depicts another variation of a suitable antenna assembly, which is similar in most respects to FIGS. 4A and 4B, except that it lacks threaded first and second mating 10 sections adjacent to the junction member 550. In this variation, the antenna assembly is held together by the distal and proximal threads. That is, distal section 556 is threaded 552 at its terminal end. Similarly, proximal section 558 is threaded at its terminal end 554.



FIG. 5 shows a further variation of a reinforced microwave antenna assembly. In this variation, the entire distal radiating section 220 is integrally formed with reinforcing member 270 and inner conductor 244. Reinforcing member 270 resides within junction member 250 with distal radiating section extending distally from reinforcing member 270. Junction member 250 includes threaded first and second mating sections 252 and 254. Mating section 254 of junction member 250 is externally threaded as shown, and is screwed on to internal threads 268 of proximal radiating section 222. Mating section 252, however, is internally threaded and is screwed on to externally threaded section 266 of junction member 250. In addition to reinforcing junction member 250, this configuration provides for continuous electrical communication of the inner conductor to the distal radiating portion.


Antenna Assembly with Reinforced Junction Member and Thermocouple



FIGS. 6A-6C show yet a further variation of a reinforced microwave antenna assembly. In this variation, reinforcing member 370 is similar to reinforcing member 170 of FIGS. 4A and 4B in that it also includes a central section 372 that resides within junction member 350. Junction member 350 is similar to junction members 50 and 150 of FIGS. 3A-3B and 4 in that it includes threaded first and second mating sections 352 and 354, which are screwed on to internal threads 366 and 368 of distal and proximal radiating sections 320 and 322. Reinforcing member 370 includes a distal section 374 that extends distally from the junction member into the distal radiating portion. Distal section 374 is threaded 376 at its terminal end. Distal radiating section 320 is formed of tapered distal tip 324 and section 322 that each have internal threads 325 and 327, respectively, that are aligned to both engage the threaded portion 376 of the reinforcing member, as shown. This allows the distal section 374 to be screwed into the distal radiation portion, providing for increased strength and rigidity to the distal radiating portion. Unlike reinforcing member 170, however, reinforcing member 370 contains a central channel 377 that receives and allows passage of inner conductor 344 through junction member 350. As shown most clearly in FIG. 6B, inner conductor 344 extends the length of the assembly to its distal tip 324 where it emerges from the assembly. Inner conductor 344 terminates in needle tip 345. As also shown, the inner conductor is hollow, allowing passage of thermocouple 380 which is positioned within the inner conductor lumen with thermocouple junction 382 at the tip. While tip 382 is shown as rounded or blunt, it need not be. That is, tip 382 can have any suitable geometry, e.g., it can be sharp, or have a piercing distal tip. In addition, thermocouple 380 may be slidable within the antenna, and may even be configured to extend out of the distal end of the antenna. Like the tip 382, the thermocouple 380 may have any suitable geometry. For example, it can be configured, such that when it is deployed out of the distal end of the antenna, it assumes a curved configuration. The thermocouple can provide and monitor localized temperature readings of tissue when the device is operated. Other monitoring devices can be deployed through the inner conductor lumen, including but not limited to sensors and transducers that respond to, e.g., electrical, magnetic, optical, thermal or mechanical stimulus. The inner conductor lumen can also be used to deliver fluids, such as irrigation fluids, or therapeutics, or to remove tissue or fluid samples. Additional thermocouples or other monitoring devices can also be provided. For example, as shown most clearly in FIG. 6C, thermocouple 390 having thermocouple junction 392 is positioned proximal of proximal radiating section 322 in lumen 347 between outer conductor 342 and shaft 314. Lumen 347 can contain e.g., a cooling fluid and thermocouple 390 can be used to measure the temperature of such cooling fluid.


Antenna Assembly with Reinforced Junction Member and Cooling Chamber



FIG. 7 shows another variation of a reinforced microwave antenna assembly. In this variation, reinforcing member 470 is similar to reinforcing member 170 of FIG. 4A. Junction member 450 is also similar to junction member 150 of FIG. 4A in that it includes threaded first and second mating sections 452 and 454, which are screwed on to internal threads 466 and 468 of distal and proximal radiating sections 420 and 422. Reinforcing member 470 includes a distal section 474 that extends distally from the junction member into the distal radiating portion. Distal section 474 is threaded 476 at its terminal end. Distal radiating section 420 terminates with tapered distal tip 424 (although, as noted above, in some situations, the distal tip need not be tapered).


A dielectric 446 is positioned longitudinally between inner conductor 444 and outer conductor 448 to electrically separate them, In this variation, a cooling tube 456 is positioned longitudinally adjacent to outer conductor 448, and a cooling jacket 458 is positioned longitudinally adjacent to cooling tube 456, making up a cooling chamber. While not shown if FIG. 7, the proximal end of the cooling tube is connected to a source of cooling fluid. The cooling fluid passes through the cooling tube 456 (e.g., a polyimide tube or the like) to cool down the tissue immediately adjacent to cooling jacket 458 to prevent burning or other tissue damage. The cooling fluid may be any suitable fluid (e.g., water, saline, etc.).


Materials and Methods


Junction members used in the antenna assemblies described herein are preferably made of a dielectric material such as a ceramic or other suitable dielectric. Illustrative examples of suitable dielectric materials include, but are not limited to Al2O3, Boron Nitride, stabilized Zirconia, air, and the like. Alternatively, junction members can made of a metal and sufficiently coated with a dielectric or polymer (e.g., high temperature polymers like polyimide or Ultem™ provided the dielectric coating is sufficiently thick to provide adequate insulation. To prevent energy from conducting directly into the tissue during use, a dielectric layer having a thickness between about 0.0001 to 0.025 inches may be coated directly over the antenna assembly. The dielectric coating may increase the radiated energy and is preferably made from a ceramic material, such as Al2O3, TiO2, or the like, and may also be optionally further coated with a lubricious material such as Teflon™, polytetrafluoroethylene (PTFE), or fluorinated ethylene propylene (FEP), etc. In addition to the dielectric coating, a sealant layer may also be coated either directly over the antenna assembly, or preferably over the dielectric layer to provide a lubricious surface for facilitating insertion into a patient as well as to prevent tissue from sticking to the antenna assembly. The sealant layer may be any variety of polymer, but is preferably a thermoplastic polymer and may have a thickness varying from a few angstroms to as thick as necessary for the application at hand. The sealant layer may be made from a variety of thermoplastic polymers, e.g., heat shrink polymers, such as polyethylene (PE), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), fluorinated ethylene propylene (FEP), perfluoroalkoxy (PFA), chlorotrifluoroethylene (CTFE), ethylene chlortrifluoroethylene (ECTFE), and ethylene tetrafluoroethylene (ETFE). Varying these coating thicknesses over antenna assembly may vary the effective wavelengths, λeff, of the radiation being transmitted by the antenna. Thus, one may vary the coating thicknesses over the assembly to achieve a predetermined effective wavelength depending upon the desired results.


A preferable method of optimizing the amount of radiated energy from the assembly may include adjusting the length of proximal radiating portion to correspond to a length of nλ/4 (where n is any integer) of the radiation being transmitted through assembly, and likewise adjusting a cumulative (or overall) length of distal radiating portion and junction to also correspond to a length of nλ/4. Adjusting the lengths of proximal and distal radiating portions to correspond to the wavelength of the transmitted microwaves may be done to optimize the amount of radiated energy and accordingly, the amount of the medium or tissue that is subsequently heated. The actual lengths of proximal and distal radiating portions may, of course, vary and is not constrained to meet any particular nλ/4 length. When an antenna assembly is radiating energy, the ablation field is variable 3-dimensionally and may be roughly spherical or ellipsoidal, which centers on the junction member and extends to the ends of the proximal and distal radiating portions.


The location of the distal tip may be proportional to a distance of nλ/4 of the radiation being transmitted through the assembly. However, since the distal tip typically terminates at tapered end, the angled surface of taper may be taken into account. Thus, the total distance along the outer surfaces of the junction member and distal radiating portion (including any tapered end) may accord to the distance of nλ/4. The length of proximal radiating portion may also accord to the distance of nλ/4, as above. Although it is preferable to have the length of the radiating portion of the antenna accord with a distance of the wavelength, λ, it is not necessary for operation of the device, as described above. That is, an antenna assembly having a radiating portion with a length in accordance with a first wavelength may generally still be used for transmitting radiation having a second wavelength, or third wavelength, or so on, although with a possible reduction in efficiency. Also, while the variations described above are related to dipole antenna assemblies, monopole antenna assemblies are also contemplated.


To improve the energy focus of an antenna assembly, an electrical choke may also be used to contain returning currents to the distal end of the antenna, as is described in U.S. patent application Ser. No. 10/052,848 filed Nov. 2, 2001, now U.S. Pat. No. 6,878,147, which is incorporated herein by reference in its entirety. Generally, the choke may be disposed on the antenna proximal of the radiating section. The choke is preferably placed over a dielectric material, which may be disposed over the antenna. The choke is preferably a conductive layer and may be further covered by a tubing or coating to force the conductive layer to conform to the underlying antenna, thereby forcing an electrical connection (or short) more distally and closer to the radiating section. The electrical connection between the choke and the underlying antenna may also be achieved by other connection methods such as soldering, welding, brazing, crimping, use of conductive adhesives, and the like.


Additional steps may optionally be taken to further increase the strength of an antenna assembly by altering any of the layers, such as sealant layer or any of the other heatshrink layers discussed above. Wires or strands may be formed within, or on, the layers to add strength and are preferably orientated longitudinally along the length of the antenna such that the bending strength of the antenna is increased. The layers may be formed over the outer conductor, as described above, and the wires may be made of any high-strength material, e.g., Kevlar, metals, etc. Metal wires may be used, provided they are insulated.


Antenna Deployment


As described above, the microwave antenna may be inserted directly into the tissue and into the lesion to be treated. However, during insertion, the antenna may encounter resistance from some areas of tissue, particularly in some tissue found, e.g., in the breast. When the microwave antenna encounters resistance, if force were applied, tissue damage may result or the target tissue may be inadvertently pushed away due to the differential density of the target tissue relative to the surrounding tissue. Therefore, RF energy may also be utilized with the microwave antenna for facilitating deployment within the tissue.


In use, the RF energy may be simply left on the entire time the antenna is advanced through the tissue, or it may be applied or turned on only as needed as the antenna encounters resistance from the tissue. With the RF energy activated, the antenna may be further advanced utilizing the RF energy to cut through the obstructive tissue. Once the antenna has been desirably positioned within a lesion or region of tissue, the RF energy, if on, may be switched off and the microwave energy may be switched on to effect treatment.


In certain variations, the assembly may use RF energy at the distal tip of the antenna as a cutting mechanism during antenna deployment. The microwave antenna is preferably covered with some insulative material along most of its length, but distal tip may be uninsulated such that the FW energy may be applied thereto through the inner conductor. To utilize the RF energy cutting mechanism at the distal tip, the inner conductor may be made from Nitinol, Tungsten, stainless steel, or some other conductive metal.


The antenna assembly may be electrically connected to an RF generator that provides the RF energy to the distal tip during placement and positioning of the antenna within the tissue or lesion. After the antenna has been desirably positioned within the lesion, the connector may be disconnected from the RF cable and attached to a microwave generator via a microwave cable to provide the microwave energy for effecting treatment to the tissue.


Alternatively, given the small amount of surface area of the distal tip of the assembly, a low power FW generator may be utilized and can be built into an integral unit along with the microwave generator. Alternatively, an optional RF generator may be physically separated from the microwave generator and may be electrically connected as a separate unit to the antenna.


Aside from the illustrations of possible antenna deployment methods and devices described above, other variations for deployment and insertion into tissue may be utilized. Potential other methods and devices for antenna deployment and insertion may be found in U.S. Pat. No. 7,197,363, filed Sep.. 15, 2002, which is commonly owned and is incorporated herein by reference in its entirety.


Methods of Use


In using a microwave antenna, several different methods may be utilized, including the use of single or multiple antennas, as is further described U.S. patent application Ser. No. 10/052,848 filed Nov. 2, 2001, now U.S. Pat. No. 6,878,147, which is incorporated herein by reference in its entirety.


The applications of the antenna assemblies and methods of making the assemblies discussed above are not limited to microwave antennas used for hyperthermic, ablation, and coagulation treatments but may include any number of further microwave antenna applications. Modification of the above-described assemblies and methods for carrying out the invention, and variations of aspects of the invention that are obvious to those of skill in the art are intended to be within the scope of the claims.

Claims
  • 1. A microwave antenna assembly, comprising: a radiating portion configured to operably couple to a source of microwave energy, the radiating portion including: a proximal radiating portion including: an outer conductor;an inner conductor disposed within the outer conductor; anda dielectric material disposed between the outer and inner conductors; anda distal radiating portion disposed distally of the proximal radiating portion, the inner conductor extending longitudinally within the distal radiating portion;a lumen formed around the outer conductor and configured to receive cooling fluid therein; anda thermocouple disposed within the radiating portion and configured to sense temperature within the radiating portion.
  • 2. The microwave antenna assembly according to claim 1, further comprising a temperature sensor disposed within the lumen and configured to sense temperature of the cooling fluid.
  • 3. The microwave antenna assembly according to claim 1, wherein the thermocouple includes a blunt distal tip.
  • 4. The microwave antenna assembly according to claim 1, wherein the thermocouple extends distally at least partially along a longitudinal length of the radiating portion and terminates in a thermocouple junction.
  • 5. The microwave antenna assembly according to claim 1, wherein the thermocouple is at least partially disposed within the inner conductor.
  • 6. The microwave antenna assembly according to claim 1, further comprising a junction member disposed between the proximal and distal radiating portions, the inner conductor extending longitudinally through the junction member.
  • 7. The microwave antenna assembly according to claim 6, further comprising a reinforcing member disposed within the junction member, wherein the reinforcing member is more rigid than the junction member.
  • 8. A microwave ablation system, comprising: a source of microwave energy; anda microwave antenna assembly including: a proximal radiating portion configured to be operably coupled to the source of microwave energy, the proximal radiating portion including:an outer conductor;an inner conductor disposed within the outer conductor; anda dielectric material disposed between the outer and inner conductors; anda distal radiating portion disposed distally of the proximal radiating portion, the inner conductor extending longitudinally within the distal radiating portion;a lumen formed around the outer conductor and configured to receive cooling fluid therein; anda thermocouple disposed within at least one of the proximal or distal radiating portions and configured to sense temperature within the at least one of the proximal or distal radiating portions.
  • 9. The microwave ablation system according to claim 8, wherein the antenna assembly further includes a temperature sensor disposed within the lumen and configured to sense temperature of the cooling fluid.
  • 10. The microwave ablation system according to claim 8, wherein the thermocouple includes a blunt distal tip.
  • 11. The microwave ablation system according to claim 8, wherein the thermocouple is disposed distally of a distal end of the inner conductor.
  • 12. The microwave ablation system according to claim 8, wherein the thermocouple is at least partially disposed within the inner conductor.
  • 13. The microwave ablation system according to claim 8, wherein the antenna assembly further includes a junction member disposed between the proximal and distal radiating portions, the inner conductor extending longitudinally through the junction member.
  • 14. The microwave ablation system according to claim 13, wherein the antenna assembly further includes a reinforcing member disposed within the junction member, wherein the reinforcing member is more rigid than the junction member.
CROSS-REFERENCE TO RELATED APPLICATIONS

The present application is a continuation application of U.S. patent application Ser. No. 14/153,644, filed on Jan. 13, 2014, which is a continuation application of U.S. patent application Ser. No. 13/479,588, filed on May 24, 2012, now U.S. Pat. No. 8,663,213, which is a continuation application of U.S. patent application Ser. No. 13/214,503, filed on Aug. 22, 2011, now U.S. Pat. No. 8,192,423, which is a continuation application of U.S. patent application Ser. No. 12/859,841, filed on Aug. 20, 2010, now U.S. Pat. No. 8,012,148, which is a continuation application of U.S. patent application Ser. No. 11/126,531, now U.S. Pat. No. 7,799,019, filed on May 10, 2005, the entire contents of each of which are incorporated herein by reference.

US Referenced Citations (272)
Number Name Date Kind
4140130 Storm, III Feb 1979 A
4204549 Paglione May 1980 A
4292960 Paglione Oct 1981 A
4311154 Sterzer et al. Jan 1982 A
4375220 Matvias Mar 1983 A
4409993 Furihata Oct 1983 A
4534347 Taylor Aug 1985 A
4557272 Carr Dec 1985 A
4583869 Chive et al. Apr 1986 A
4612940 Kasevich et al. Sep 1986 A
4621642 Chen Nov 1986 A
4658836 Turner Apr 1987 A
4700716 Kasevich et al. Oct 1987 A
4776086 Kasevich et al. Oct 1988 A
4800899 Elliott Jan 1989 A
4823812 Eshel et al. Apr 1989 A
4841988 Fetter et al. Jun 1989 A
4945912 Langberg Aug 1990 A
5097845 Fetter et al. Mar 1992 A
5122137 Lennox Jun 1992 A
5190054 Fetter et al. Mar 1993 A
5221269 Miller et al. Jun 1993 A
5234004 Hascoet et al. Aug 1993 A
5246438 Langberg Sep 1993 A
5249585 Turner et al. Oct 1993 A
5275597 Higgins et al. Jan 1994 A
5281217 Edwards et al. Jan 1994 A
5301687 Wong et al. Apr 1994 A
5314466 Stern et al. May 1994 A
5342355 Long Aug 1994 A
5344441 Gronauer Sep 1994 A
5366490 Edwards et al. Nov 1994 A
5370644 Langberg Dec 1994 A
5370676 Sozanski et al. Dec 1994 A
5383922 Zipes et al. Jan 1995 A
5405346 Grundy et al. Apr 1995 A
5413588 Rudie et al. May 1995 A
5433740 Yamaguchi Jul 1995 A
5458597 Edwards et al. Oct 1995 A
5464445 Rudie et al. Nov 1995 A
5480417 Hascoet et al. Jan 1996 A
5500012 Brucker et al. Mar 1996 A
5507743 Edwards et al. Apr 1996 A
5509929 Hascoet et al. Apr 1996 A
5520684 Imran May 1996 A
5536267 Edwards et al. Jul 1996 A
5545137 Rudie et al. Aug 1996 A
5556377 Rosen et al. Sep 1996 A
5599294 Edwards et al. Feb 1997 A
5599295 Rosen et al. Feb 1997 A
5628770 Thome et al. May 1997 A
5683382 Lenihan et al. Nov 1997 A
5720718 Rosen et al. Feb 1998 A
5741249 Moss et al. Apr 1998 A
5755754 Rudie et al. May 1998 A
5776176 Rudie Jul 1998 A
5800486 Thome et al. Sep 1998 A
5810803 Moss et al. Sep 1998 A
5810804 Gough et al. Sep 1998 A
5829519 Uthe Nov 1998 A
5843144 Rudie et al. Dec 1998 A
5871523 Fleischman et al. Feb 1999 A
5897554 Chia et al. Apr 1999 A
5902251 vanHooydonk May 1999 A
5904691 Barnett et al. May 1999 A
5904709 Arndt et al. May 1999 A
5916240 Rudie et al. Jun 1999 A
5931807 McClure et al. Aug 1999 A
5931860 Reid et al. Aug 1999 A
5938692 Rudie Aug 1999 A
5951547 Gough et al. Sep 1999 A
5957969 Warner et al. Sep 1999 A
5964755 Edwards Oct 1999 A
5974343 Brevard et al. Oct 1999 A
5980563 Tu et al. Nov 1999 A
5997532 McLaughlin et al. Dec 1999 A
6016452 Kasevich Jan 2000 A
6016811 Knopp et al. Jan 2000 A
6026331 Feldberg et al. Feb 2000 A
6032078 Rudie Feb 2000 A
6047216 Carl et al. Apr 2000 A
6056744 Edwards May 2000 A
6059780 Gough et al. May 2000 A
6063078 Wittkampf May 2000 A
6073051 Sharkey et al. Jun 2000 A
6080150 Gough Jun 2000 A
6097985 Kasevich et al. Aug 2000 A
6106518 Wittenberger et al. Aug 2000 A
6122551 Rudie et al. Sep 2000 A
6134476 Arndt et al. Oct 2000 A
6146379 Fleischman et al. Nov 2000 A
6176856 Jandak et al. Jan 2001 B1
6181970 Kasevich Jan 2001 B1
6217528 Koblish et al. Apr 2001 B1
6223086 Carl et al. Apr 2001 B1
6226553 Carl et al. May 2001 B1
6233490 Kasevich May 2001 B1
6235048 Dobak, III May 2001 B1
6245064 Lesh et al. Jun 2001 B1
6251128 Knopp et al. Jun 2001 B1
6275738 Kasevich et al. Aug 2001 B1
6277113 Berube Aug 2001 B1
6289249 Arndt et al. Sep 2001 B1
6290715 Sharkey et al. Sep 2001 B1
6306132 Moorman et al. Oct 2001 B1
6325796 Berube et al. Dec 2001 B1
6330479 Stauffer Dec 2001 B1
6346104 Daly et al. Feb 2002 B2
6347251 Deng Feb 2002 B1
6350262 Ashley Feb 2002 B1
6355033 Moorman et al. Mar 2002 B1
6383182 Berube et al. May 2002 B1
6405733 Fogarty et al. Jun 2002 B1
6471696 Berube et al. Oct 2002 B1
6496736 Carl et al. Dec 2002 B1
6496737 Rudie et al. Dec 2002 B2
6506189 Rittman, III et al. Jan 2003 B1
6512956 Arndt et al. Jan 2003 B2
6514251 Ni et al. Feb 2003 B1
6530922 Cosman et al. Mar 2003 B2
6564806 Fogarty et al. May 2003 B1
6569159 Edwards et al. May 2003 B1
6577903 Cronin et al. Jun 2003 B1
6589234 Lalonde et al. Jul 2003 B2
6592579 Arndt et al. Jul 2003 B2
6640139 Ueberle Oct 2003 B1
6663624 Edwards et al. Dec 2003 B2
6675050 Arndt et al. Jan 2004 B2
6685700 Behl et al. Feb 2004 B2
6699241 Rappaport et al. Mar 2004 B2
6706040 Mahon et al. Mar 2004 B2
6722371 Bush et al. Apr 2004 B1
6752154 Fogarty et al. Jun 2004 B2
6752767 Turovskiy et al. Jun 2004 B2
6823218 Berube Nov 2004 B2
6852091 Edwards et al. Feb 2005 B2
6878147 Prakash et al. Apr 2005 B2
7128739 Prakash et al. Oct 2006 B2
7147632 Prakash et al. Dec 2006 B2
7174217 Rioux et al. Feb 2007 B2
7190989 Swanson et al. Mar 2007 B1
7207985 Duong et al. Apr 2007 B2
7217282 Ginsburg et al. May 2007 B2
7229437 Johnson et al. Jun 2007 B2
7231259 Jenney et al. Jun 2007 B2
7234225 Johnson et al. Jun 2007 B2
7234977 Westlund et al. Jun 2007 B2
7235070 Vanney Jun 2007 B2
7238166 Callister Jul 2007 B2
7238184 Megerman et al. Jul 2007 B2
7238194 Monstadt et al. Jul 2007 B2
7241293 Davison Jul 2007 B2
7244254 Brace et al. Jul 2007 B2
7245955 Rashidi Jul 2007 B2
7264619 Venturelli Sep 2007 B2
7270656 Gowda et al. Sep 2007 B2
7270658 Woloszko et al. Sep 2007 B2
7270659 Ricart et al. Sep 2007 B2
7270661 Dahla et al. Sep 2007 B2
7270662 Visram et al. Sep 2007 B2
7271363 Lee et al. Sep 2007 B2
7273480 Young et al. Sep 2007 B2
7276061 Schaer et al. Oct 2007 B2
7282049 Orszulak et al. Oct 2007 B2
7285116 de la Rama et al. Oct 2007 B2
7293562 Malecki et al. Nov 2007 B2
7300438 Falwell et al. Nov 2007 B2
7301131 Gauthier et al. Nov 2007 B2
7306592 Morgan et al. Dec 2007 B2
7309325 Mulier et al. Dec 2007 B2
7309336 Ashley et al. Dec 2007 B2
7311702 Tallarida et al. Dec 2007 B2
7311703 Turovskiy et al. Dec 2007 B2
7311705 Sra Dec 2007 B2
7317949 Morrison et al. Jan 2008 B2
7318822 Darmos et al. Jan 2008 B2
7318823 Sharps et al. Jan 2008 B2
7318824 Prakash et al. Jan 2008 B2
7319904 Cross, Jr. et al. Jan 2008 B2
7326204 Paul et al. Feb 2008 B2
7326205 Paul et al. Feb 2008 B2
7326206 Paul et al. Feb 2008 B2
7331957 Woloszko et al. Feb 2008 B2
7337009 Schell Feb 2008 B2
7799019 Turovskiy et al. Sep 2010 B2
8012148 Turovskiy et al. Sep 2011 B2
8192423 Turovskiy et al. Jun 2012 B2
8663213 Turovskiy et al. Mar 2014 B2
8974452 Turovskiy et al. Mar 2015 B2
20010001819 Lee et al. May 2001 A1
20010008966 Arndt et al. Jul 2001 A1
20010020178 Arndt et al. Sep 2001 A1
20010020180 Arndt et al. Sep 2001 A1
20010037812 Dobak et al. Nov 2001 A1
20020022832 Mikus et al. Feb 2002 A1
20020087151 Mody et al. Jul 2002 A1
20020133148 Daniel et al. Sep 2002 A1
20020147444 Shah et al. Oct 2002 A1
20020198520 Coen et al. Dec 2002 A1
20030004506 Messing Jan 2003 A1
20030065317 Rudie et al. Apr 2003 A1
20030069578 Hall et al. Apr 2003 A1
20030078573 Truckai et al. Apr 2003 A1
20030088242 Prakash et al. May 2003 A1
20030109862 Prakash et al. Jun 2003 A1
20030195499 Prakash et al. Oct 2003 A1
20040078038 Desinger et al. Apr 2004 A1
20040167517 Desinger et al. Aug 2004 A1
20040168692 Fogarty et al. Sep 2004 A1
20040243200 Turner et al. Dec 2004 A1
20040267156 Turovskiy et al. Dec 2004 A1
20050015081 Turovskiy et al. Jan 2005 A1
20050065508 Johnson et al. Mar 2005 A1
20050085881 Prakash et al. Apr 2005 A1
20050107783 Tom et al. May 2005 A1
20050148836 Kleen et al. Jul 2005 A1
20050159741 Paul et al. Jul 2005 A1
20060026492 Rhee et al. Feb 2006 A1
20060028206 Zhang et al. Feb 2006 A1
20060264923 Prakash et al. Nov 2006 A1
20060282069 Prakash et al. Dec 2006 A1
20070027451 Desinger et al. Feb 2007 A1
20070073282 McGaffigan et al. Mar 2007 A1
20070123765 Hetke et al. May 2007 A1
20070129715 Eggers et al. Jun 2007 A1
20070135879 McIntyre et al. Jun 2007 A1
20070142829 Ahn et al. Jun 2007 A1
20070149964 Kawabata et al. Jun 2007 A1
20070156048 Panescu et al. Jul 2007 A1
20070156128 Jimenez Jul 2007 A1
20070156132 Drysen Jul 2007 A1
20070156133 McDaniel et al. Jul 2007 A1
20070173680 Rioux et al. Jul 2007 A1
20070173798 Adams et al. Jul 2007 A1
20070173812 Bonan et al. Jul 2007 A1
20070179375 Fuimaono et al. Aug 2007 A1
20070179497 Eggers et al. Aug 2007 A1
20070185478 Cosentino Aug 2007 A1
20070191825 Cronin et al. Aug 2007 A1
20070203551 Cronin et al. Aug 2007 A1
20070208334 Woloszko et al. Sep 2007 A1
20070208335 Woloszko et al. Sep 2007 A1
20070208383 Williams Sep 2007 A1
20070213700 Davison et al. Sep 2007 A1
20070213703 Naam et al. Sep 2007 A1
20070215163 Harrington et al. Sep 2007 A1
20070219551 Honour et al. Sep 2007 A1
20070225701 O'Sullivan Sep 2007 A1
20070233057 Konishi Oct 2007 A1
20070244529 Choi et al. Oct 2007 A1
20070250053 Fernald et al. Oct 2007 A1
20070250054 Drake Oct 2007 A1
20070250055 Johnson et al. Oct 2007 A1
20070250056 Vanney Oct 2007 A1
20070255276 Sliwa et al. Nov 2007 A1
20070260235 Podhajsky Nov 2007 A1
20070260237 Sutton et al. Nov 2007 A1
20070270679 Nguyen et al. Nov 2007 A1
20070270791 Wang et al. Nov 2007 A1
20070276361 Stevens-Wright et al. Nov 2007 A1
20070276362 Rioux et al. Nov 2007 A1
20070282323 Woloszko et al. Dec 2007 A1
20070282324 Vaska et al. Dec 2007 A1
20070282325 Young et al. Dec 2007 A1
20070287995 Mayse Dec 2007 A1
20070287998 Sharareh et al. Dec 2007 A1
20070293853 Truckai et al. Dec 2007 A1
20070293854 Pless et al. Dec 2007 A1
20070293855 Sliwa et al. Dec 2007 A1
20070299488 Carr Dec 2007 A1
20080004614 Burdette et al. Jan 2008 A1
20080004618 Johnson et al. Jan 2008 A1
Foreign Referenced Citations (22)
Number Date Country
0 521 264 Jan 1993 EP
0 667 126 Aug 1995 EP
9320767 Oct 1993 WO
9320768 Oct 1993 WO
9501814 Jan 1995 WO
9634571 Nov 1996 WO
9748449 Dec 1997 WO
9748450 Dec 1997 WO
9748451 Dec 1997 WO
9956642 Nov 1999 WO
9956643 Nov 1999 WO
9956812 Nov 1999 WO
0049957 Aug 2000 WO
0057811 Oct 2000 WO
0160235 Aug 2001 WO
02078777 Oct 2002 WO
03034932 May 2003 WO
03039385 May 2003 WO
03047043 Jun 2003 WO
03088806 Oct 2003 WO
03088858 Oct 2003 WO
2005011049 Feb 2005 WO
Non-Patent Literature Citations (7)
Entry
U.S. Pat. No. 5,326,343, 07/1994, Rudie et al. (withdrawn).
I Chou, C.K. (1995). “Radiofrequency Hyperthermia in Cancer Therapy,” Biologic Effects of Nonionizing Electromagnetic Fields. Chapter 94, CRC Press, Inc. pp. 1424-1428.
Urologix, Inc.—Medical Professionals: Targis3 Technology http://www.urologix.com/medical/technology.html (total pp. 3).
International Search Report—EP 06 00 9435 dated Jul. 13, 2006.
Urologix, Inc.—Medical Professionals: Targis Technology http://www.urologix.com/medical/technology.html; 3 pages.
International Search Report corresponding to European Application No. EP 06 00 9435.6, completed Jul. 6, 2006; mailed Jul. 13, 2006; 3 pages.
Official Action issued in the corresponding Japanese Application No. 2006-128689 dated Sep. 29, 2011.
Related Publications (1)
Number Date Country
20150173833 A1 Jun 2015 US
Continuations (5)
Number Date Country
Parent 14153644 Jan 2014 US
Child 14640174 US
Parent 13479588 May 2012 US
Child 14153644 US
Parent 13214503 Aug 2011 US
Child 13479588 US
Parent 12859841 Aug 2010 US
Child 13214503 US
Parent 11126531 May 2005 US
Child 12859841 US