Claims
- 1. A method for treating autoimmune diseases affecting the blood vessels comprising administering to a patient in need thereof a therapeutically effective amount of toremifene or a pharmaceutically acceptable salt thereof.
- 2. A method of claim 1 wherein the autoimmune disease affecting the blood vessels is necrotizing angitis or granulomatous angitis.
- 3. A method according to claim 1, wherein said autoimmune diseases are autoimmune degenerative diseases of blood vessels.
- 4. A method according to claim 1, further comprising administering a glucocorticoid concomitantly with said toremifene or said pharmaceutically acceptable salt thereof.
Priority Claims (2)
Number |
Date |
Country |
Kind |
4-310772 |
Oct 1992 |
JP |
|
PCT/JP93/01543 |
Oct 1993 |
WO |
|
Parent Case Info
This application is a divisional of Ser. No. 08/844,846 filed Apr. 22, 1997, now U.S. Pat. No. 5,886,049, which is a continuation of Ser. No. 08/448,248 filed Apr. 25, 1995, now abandoned, which is a 371 of PCT/JP93/01543, filed Oct. 26, 1993, and priority based on Japenese Patent Application 04-310772 filed Oct. 27, 1992.
US Referenced Citations (2)
Number |
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Date |
Kind |
4696949 |
Toivola et al. |
Sep 1987 |
|
5254594 |
Niikura et al. |
Oct 1993 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
0 415 623 |
Mar 1991 |
EP |
9322685 |
Nov 1993 |
WO |
Non-Patent Literature Citations (6)
Entry |
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Arthritis and Rheumatism, vol. 21, No. 4 (May 1978) pp. 414-417 (1978); Madeleine Duvic et al.; “Effect Of The Anti-Estrogen, Nafoxidine, On NZB/W Autoimmune Disease”. |
Hosp. Pract., vol. 18, No. 9, 1983, pp. 205-220, XP000646451 W.J. Herringtone et al.; “Treatment of idiopathic thrombacytopenic purpura”. |
British Journal of Dermatology (1989) 121, pp. 135-137; C.J.M. Stephens, et al. “Autoimmune progesterone dermatitis responding to Tamoxifen”. |
Annales De Dermatologie et De Venereologie, vol. 118, No. 9 (1991) pp. 551-555; F.Freychet, et al. “La Dermatose Auto-Immune A La Progesterone”. |
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Continuations (1)
|
Number |
Date |
Country |
Parent |
08/448348 |
Apr 1995 |
US |
Child |
08/844846 |
|
US |