Claims
- 1. A method for determining a parameter which is indicative of the condition of a hollow viscus internal organ in a human or other mammal, comprising the steps of:
- (a) placing a catheter having a membrane permeable to carbon dioxide adjacent to the wall of the organ, the condition of which is to be indicated by the determined parameter, so that carbon dioxide associated with the wall of the organ passes across the permeable membrane;
- (b) measuring the partial pressure of carbon dioxide associated with the wall of the organ;
- (c) measuring the carbon dioxide level associated with the blood of said human or other mammal; and
- (d) determining said parameter by relating said measurements.
- 2. A method according to claim 1, wherein the parameter is pCO.sub.2 -gap.
- 3. A method according to claim 2, wherein the method further includes the step of generating a visually perceptible representation of said pCO.sub.2 -gap parameter.
- 4. A method according to claim 2, including the step of recording at least a machine readable representation of said pCO.sub.2 -gap parameter.
- 5. A method according to claim 1, wherein the parameter is pH-gap.
- 6. A method according to claim 5, wherein the method further includes the step of generating a visually perceptible representation of said pH-gap parameter.
- 7. A method according to claim 5, including the step of recording at least a machine readable representation of said pH-gap parameter.
- 8. A method according to claim 5, wherein said pH-gap parameter is integrated over time to assess cumulative effects of tissue damage.
- 9. A method according to claim 1, wherein step (a) is further defined as obtaining gas containing carbon dioxide from the wall of the organ and wherein step (b) is further defined as subjecting the gas to analysis by infrared detection means.
- 10. A method according to claim 1, wherein step (a) is further defined as obtaining gas containing carbon dioxide from the wall of the organ and wherein step (b) is further defined as subjecting the gas to analysis by Raman spectroscopy means.
- 11. A method according to claim 1, further including the step of measuring the pH level associated with the blood of said human or other mammal.
- 12. A method according to claim 11, wherein the parameter is pHi, the pH associated with the wall of the organ, and wherein the determining step relates the measurements of steps (b) and (c) and of the pH level associated with the blood to determine pHi.
- 13. A method according to claim 12, wherein the method further includes the step of generating a visually perceptible representation of pHi.
- 14. A method according to claim 12, including the step of recording at least a machine readable representation of said pHi parameter.
- 15. A method according to claim 1, wherein steps (a), (b), and (c) further comprise the steps of placing a catheter having a membrane permeable to oxygen so that oxygen associated with the wall of the organ passes across the permeable membrane and of measuring the pO.sub.2 associated with the organ wall and with the blood.
- 16. A method according to claim 2, wherein steps (a), (b), and (c) further comprise the steps of placing a catheter having a membrane permeable to oxygen so that oxygen associated with the wall of the organ passes across the permeable membrane and of measuring the pO.sub.2 associated with the organ wall and with the blood and wherein step (d) is further defined as determining a pO.sub.2 -gap parameter by relating the measurements of the pO.sub.2 associated with the organ wall and with the blood.
- 17. A method according to claim 1, further comprising the step of taking the derivative with respect to time of the measurement of the partial pressure of carbon dioxide associated with the wall of the organ, to assess the rate and direction of change of the measurement.
- 18. A method for determining a parameter which is indicative of the condition of a hollow viscus internal organ in a human or other mammal in need of such determination comprising the steps of:
- (a) placing a catheter having a membrane permeable to carbon dioxide adjacent to the wall of the organ, the condition of which is to be indicated by the determined parameter, so that carbon dioxide associated with the wall of the organ passes across the permeable membrane;
- (b) measuring the partial pressure of carbon dioxide associated with the wall of the organ;
- (c) estimating the carbon dioxide level of the arterial blood of said human or other mammal by subjecting said human or other mammal's end-tidal respiration to a pCO.sub.2 measurement; and
- (d) determining said parameter by relating the measurement of (b) and the estimation of (c).
- 19. A method according to claim 18, wherein the parameter is pCO.sub.2 -gap.
- 20. A method according to claim 19, further including the step of displaying the results of the determination of said pCO.sub.2 -gap parameter in a visually perceptible form.
- 21. A method according to claim 19, further including the step of recording at least a machine readable representation of said pCO.sub.2 -gap.
- 22. A method according to claim 18, wherein the parameter is pH-gap.
- 23. A method according to claim 22, further including the step of displaying the results of the determination of said pH-gap parameter in a visually perceptible form.
- 24. A method according to claim 22, further including the step of recording at least a machine readable representation of said pH-gap parameter.
- 25. A method according to claim 22, wherein said pH-gap parameter is integrated over time to assess cumulative effects of tissue damage.
- 26. A method according to claim 18, wherein step (a) is further defined as obtaining gas containing carbon dioxide from the wall of the organ and wherein step (b) is further defined as subjecting the gas to analysis by infrared detection means.
- 27. A method according to claim 18, wherein step (a) is further defined as obtaining gas containing carbon dioxide from the wall of the organ and wherein step (b) is further defined subjecting the gas to analysis by Raman spectroscopy means.
- 28. A method according to claim 18, wherein step (c) is further defined as subjecting gas comprising the end-tidal respiration to analysis by an infrared gas analyzer.
- 29. A method according to claim 18, wherein step (c) is further defined as subjecting gas comprising the end-tidal respiration to analysis by a Raman spectrometer.
- 30. A method according to claim 18, wherein the measurement of step (b) and the estimation of step (c) are both carried out by passing CO.sub.2 -containing gas through an infrared gas analyzer.
- 31. A method according to claim 18, wherein the measurement of step (b) and the estimation of step (c) are both carried out by passing CO.sub.2 -containing gas through a Raman spectrometer.
- 32. A method according to claim 18, wherein said human or other mammal has been subjected to an anesthetic and wherein the method further includes the step of carrying out an analysis for an anesthetic associated with at least one of the wall of the organ and the end tidal respiration gases.
- 33. A method according to claim 18, further including the step of measuring the pH level associated with the blood of said human or other mammal.
- 34. A method according to claim 33, wherein the parameter is pHi, the pH associated with the wall of the organ, and wherein the determining step relates the measurement of step (b) and the estimation of step (c) and the pH level associated with the blood to determine pHi.
- 35. The method according to claim 34, further including the step of generating a visually perceptible representation of said pHi parameter.
- 36. A method according to claim 34, further including the step of recording at least a machine readable representation of said pHi parameter.
- 37. (amended) A method according to claim 18, wherein steps (a), (b), and (c) further comprise the steps of placing a catheter having a membrane permeable to oxygen so that oxygen associated with the wall of the organ passes across the permeable membrane, of measuring the pO.sub.2 associated with the organ wall and estimating the pO.sub.2 of the arterial blood by subjecting said human or other mammal's end-tidal respiration to a pO.sub.2 measurement.
- 38. A method according to claim 37 wherein step (d) is further defined as determining a pO.sub.2 -gap parameter by relating the measurement of the pO.sub.2 associated with the organ wall and the estimation of the arterial blood pO.sub.2.
- 39. A method according to claim 18, further comprising the step of taking the derivative with respect to time of the measurement of the partial pressure of carbon dioxide associated with the wall of the organ, to assess the rate and direction of change of the measurement.
- 40. A method according to claim 32 wherein the step of carrying out an analysis is further defined as analyzing for N.sub.2 O.
- 41. A method according to claim 1 wherein said human or other mammal has been subjected to an anaesthetic and wherein the method also includes the step of carrying out an analysis for an anaesthetic.
- 42. A method according to claim 41 wherein the step of carrying out an analysis is further defined as analyzing for N.sub.2 O.
- 43. A method for determining a pO.sub.2 -gap parameter which is indicative of the condition of a hollow viscus internal organ in a human or other mammal, comprising the steps of:
- (a) placing a catheter having a membrane permeable to oxygen adjacent to the wall of the organ so that oxygen associated with the wall of the organ passes across the permeable membrane;
- (b) measuring the pO.sub.2 associated with the wall of the organ;
- (c) measuring the pO.sub.2 level associated with the blood of said human or other mammal; and
- (d) determining said pO.sub.2 -gap parameter by relating said measurements.
- 44. A method according to claim 43, wherein the method further includes the step of generating a visually perceptible representation of pO.sub.2 -gap.
- 45. A method according to claim 44, including the step of recording at least a machine readable representation of said pO.sub.2 -gap.
- 46. A method according to claim 43 wherein the step of measuring the pO.sub.2 level associated with the blood of said human or other mammal is further defined as obtaining the measurement from an estimation of the oxygen level of the arterial blood of said human or other mammal obtained from subjecting said human or other mammal's end-tidal respiration to a pO2 measurement.
- 47. A method for determining at least one parameter which is indicative of the condition of a hollow viscus internal organ in a human or other mammal, comprising the steps of:
- (a) placing a catheter having a membrane permeable to carbon dioxide and oxygen adjacent to the wall of the organ so that carbon dioxide and oxygen pass across the permeable membrane;
- (b) measuring the partial pressure of carbon dioxide and the partial pressure of oxygen associated with the wall of the organ;
- (c) measuring the carbon dioxide level, the oxygen level, and the pH associated with the blood of said human or other mammal; and
- (d) determining said parameter by relating said measurements, said parameter comprising at least one of pCO.sub.2 -gap, pO.sub.2 -gap, pH-gap, and pHi, the pH associated with the wall of the organ.
Parent Case Info
This application is the U.S. national stage of PCT application PCT/U.S. Ser. No. 97/02953, filed Mar. 18, 1994, which application is a continuation-in-part of U.S. patent application Ser. No. 08/035,020, filed Mar. 22, 1993, now abandoned, which was a continuation-in-part of U.S. patent application, Ser. No. 08/014,624, filed Feb. 8, 1993, now abandoned, which was a continuation-in-part of copending U.S. patent application, Ser. No. 08/719,097, filed Jun. 20, 1991, now abandoned, which was a continuation-in-part of copending U.S. patent application, Ser. No. 08/994,721, filed Dec. 22, 1992, now abandoned.
This application hereby expressly incorporates by reference, the disclosure and drawings of the following issued U.S. patents: U.S. Pat. Nos. 4,221,567; 4,233,513; 4,273,636; 4,423,739; 4,576,590; 4,480,190; 4,596,931; 4,643,192; 4,671,287 4,859,858; 4,859,859; 4,907,166; 4,914,720; 5,042,522; 5,067,492; 5,095,913; 5,158,083; 5,174,290; and 5,186,172.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/US94/02953 |
3/18/1994 |
|
|
5/8/1995 |
5/8/1995 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO94/21163 |
9/29/1994 |
|
|
Non-Patent Literature Citations (4)
Entry |
"Gastrotonometry" An Aid to the Control of Ventilation During Artificial Respiration, D. Boda, L. Muranyi, reprinted from The Lancet, Jan. 24, 1959, pp. 181-182. |
Small Bowel Tonometry: Assessment of Small Gut Mucosal Oxygen Tension in Dog and Man, A. M. Dawson et al., Nature, vol. 206, pp. 944, May 29, 1965. |
Determination of Tissue O.sub.2 Tensions by Hollow Visceral Tonometers: Effect of Breathing Enriched O.sub.2 Mixtures, E. H. Bergofsky, Journal of Clinical Investigation, vol. 43, No. 2, p. 193, 1964. |
Elevated Systemic to Intrasmucosal Stomach Wall pH-Gap in Patients with Sepsis, Anzivino et al., Chest, 1990 Supplement. |
Continuation in Parts (4)
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Number |
Date |
Country |
Parent |
035020 |
Mar 1993 |
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Parent |
014624 |
Feb 1993 |
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Parent |
719097 |
Jun 1991 |
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Parent |
994721 |
Dec 1992 |
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