Renal nerve modulation devices and methods

Information

  • Patent Grant
  • 10835305
  • Patent Number
    10,835,305
  • Date Filed
    Thursday, October 10, 2013
    11 years ago
  • Date Issued
    Tuesday, November 17, 2020
    4 years ago
Abstract
Systems for nerve and tissue modulation are disclosed. An example system may include an intravascular nerve modulation system including an elongated shaft having a proximal end region and a distal end region. The system may further include one or more ablation electrodes affixed to the distal end region of the elongated shaft. One or more ground pad electrodes may be provided and connected to a processor configured to modulate the impedance of each circuit completed between the ablation electrodes and the ground pads.
Description
TECHNICAL FIELD

The present disclosure pertains to medical devices and methods for making and using medical devices. More particularly, the present disclosure pertains to medical devices and methods for performing renal nerve modulation.


BACKGROUND

Certain treatments require the temporary or permanent interruption or modification of select nerve function. One example treatment is renal nerve ablation, which is sometimes used to treat conditions related to congestive heart failure or hypertension. The kidneys produce a sympathetic response to congestive heart failure, which, among other effects, increases the undesired retention of water and/or sodium. Ablating some of the nerves running to the kidneys may reduce or eliminate this sympathetic function, which may provide a corresponding reduction in the associated undesired symptoms.


Many nerves, including renal nerves, run along the walls of or in close proximity to blood vessels and thus can be accessed via the blood vessels. In some instances, it may be desirable to ablate perivascular renal nerves using radiofrequency energy. In all circuits, completion of the circuit is made using the path of least resistance. In radiofrequency ablation circuits involving the body, the path of least resistance is often through muscle. Because muscle is of lower impedance than connective tissue, the propensity for generating inconsistent lesions may be greater if connective, fatty, and muscular tissues are all present. In a case such as this, the lesions generated may be of lesser or greater depth based upon tissue presence and type. Also, bowel or psoas muscle burns may occur. It may be desirable to provide for alternative systems and methods for reducing unintended lesions and for improving lesion consistency within variable anatomy.


SUMMARY

The disclosure is directed to several alternative designs, materials and use alternatives for medical device structures and assemblies. An example use may include a method for performing intravascular renal nerve modulation. The method may include providing a nerve modulation system including an elongate shaft having a proximal end region and a distal end region and one or more ablation electrodes positioned adjacent the distal end region of the elongate shaft. The system may also include two or more ground pads, a control unit electrically coupled to the one or more ablation electrodes, and a processor electrically coupled to the two or more ground pads. The modulation system may be advanced through a lumen such that the distal end region is adjacent to a target region. Voltage may then be applied to the one or more ablation electrodes, wherein energy flows between the one or more ablation electrodes and the two or more ground pads to form individual circuits. The resistance of at least one of the circuits formed between the ground pads and the ablation electrodes may also be adjusted.


An example medical device may include an intravascular nerve modulation system. The nerve modulation system may include an elongate shaft having a proximal end region and a distal end region and an ablation electrode positioned adjacent the distal end region of the elongate shaft. The system may also include at least two ground pads, a control unit electrically coupled to the one or more ablation electrodes, and a processor electrically coupled to the two or more ground pads.


The above summary of some example embodiments is not intended to describe each disclosed embodiment or every implementation of the invention. The Figures, and Detailed Description, which follow, more particularly exemplify these embodiments.





BRIEF DESCRIPTION OF THE DRAWINGS

The invention may be more completely understood in consideration of the following detailed description of various embodiments in connection with the accompanying drawings, in which:



FIG. 1 is a schematic view illustrating a renal nerve modulation system in situ;



FIG. 2 is another schematic view illustrating a renal nerve modulation system in situ; and



FIG. 3 is another schematic view illustrating a renal nerve modulation system in situ;





While the invention is amenable to various modifications and alternative forms, specifics thereof have been shown by way of example in the drawings and will be described in detail. It should be understood, however, that the intention is not to limit aspects of the invention to the particular embodiments described. On the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention.


DETAILED DESCRIPTION

For the following defined terms, these definitions shall be applied, unless a different definition is given in the claims or elsewhere in this specification.


All numeric values are herein assumed to be modified by the term “about”, whether or not explicitly indicated. The term “about” generally refers to a range of numbers that one of skill in the art would consider equivalent to the recited value (i.e., having the same function or result). In many instances, the term “about” may be indicative as including numbers that are rounded to the nearest significant figure.


The recitation of numerical ranges by endpoints includes all numbers within that range (e.g., 1 to 5 includes 1, 1.5, 2, 2.75, 3, 3.80, 4, and 5).


Although some suitable dimensions ranges and/or values pertaining to various components, features and/or specifications are disclosed, one of skill in the art, incited by the present disclosure, would understand desired dimensions, ranges and/or values may deviate from those expressly disclosed.


As used in this specification and the appended claims, the singular forms “a”, “an”, and “the” include plural referents unless the content clearly dictates otherwise. As used in this specification and the appended claims, the term “or” is generally employed in its sense including “and/or” unless the content clearly dictates otherwise.


For purposes of this disclosure, “proximal” refers to the end closer to the device operator during use, and “distal” refers to the end further from the device operator during use.


The following detailed description should be read with reference to the drawings in which similar elements in different drawings are numbered the same. The detailed description and the drawings, which are not necessarily to scale, depict illustrative embodiments and are not intended to limit the scope of the invention. The illustrative embodiments depicted are intended only as exemplary. Selected features of any illustrative embodiment may be incorporated into an additional embodiment unless clearly stated to the contrary.


Certain treatments require the temporary or permanent interruption or modification of select nerve function. One example treatment is renal nerve ablation, which is sometimes used to treat conditions related to congestive heart failure or hypertension. The kidneys produce a sympathetic response to congestive heart failure, which, among other effects, increases the undesired retention of water and/or sodium. Ablating some of the nerves running to the kidneys may reduce or eliminate this sympathetic function, which may provide a corresponding reduction in the associated undesired symptoms.


While the devices and methods described herein are discussed relative to renal nerve modulation, it is contemplated that the devices and methods may be used in other treatment locations and/or applications where nerve modulation and/or other tissue modulation including heating, activation, blocking, disrupting, or ablation are desired, such as, but not limited to: blood vessels, urinary vessels, or in other tissues via trocar and cannula access. For example, the devices and methods described herein can be applied to hyperplastic tissue ablation, tumor ablation, benign prostatic hyperplasia therapy, nerve excitation or blocking or ablation, modulation of muscle activity, hyperthermia or other warming of tissues, etc. In some instances, it may be desirable to ablate perivascular renal nerves using a radiofrequency electrode.


While the devices and methods described herein are discussed relative to renal nerve modulation through a blood vessel wall, it is contemplated that the devices and methods may be used in other applications where nerve modulation and/or ablation are desired. The term modulation refers to ablation and other techniques that may alter the function of affected nerves.


In all circuits, completion of the circuit is made using the path of least resistance. In radiofrequency ablation circuits involving the body, the path of least resistance is often through muscle. Because muscle is of lower impedance than connective tissue, the propensity for generating inconsistent lesions may be greater if connective, fatty, and muscular tissues are all present. In a case such as this, the lesions generated may be of lesser or greater depth based upon tissue presence and type. Also, bowel or psoas muscle burns may occur.



FIG. 1 is a schematic view of an illustrative renal nerve modulation system 10 in situ. System 10 may include an element 12 for providing power to a nerve modulation element disposed about and/or within a central elongate shaft 14 and, optionally, within a sheath 16. A proximal end of element 12 may be connected to a control and power element 18, which supplies the necessary electrical energy to activate the one or more modulation elements or electrodes at or near a distal end of the element 12. When suitably activated, the electrode(s) are capable of ablating tissue. The terms electrode and electrode(s) may be considered to be equivalent to elements capable of ablating adjacent tissue. In some instances, one or more return electrode patches 22a, 22b, 22c, 22d (collectively 22a-d) may be supplied on the legs or at another conventional location on the patient's body to complete the circuit. The control and power element 18 may include monitoring elements to monitor parameters such as power, temperature, voltage, pulse size, and/or shape and other suitable parameters as well as suitable controls for performing the desired procedure. In some instances, the power element 18 may control a radio frequency (RF) ablation electrode and/or one or more sensing electrode(s). It is contemplated that more than one power element 18 may be provided. The ablation electrode may be configured to operate at a frequency of approximately 460 kHz. It is contemplated that any desired frequency in the RF range may be used, for example, from 100-500 kHz. However, it is contemplated that different types of energy outside the RF spectrum may be used as desired, for example, but not limited to ultrasound, microwave, and laser to perform the ablation. While the term ablation electrode is used herein, it is contemplated that the modulation element and modulation frequency may be selected according to the energy used to perform the ablation. For example, when ultrasound energy is used, an ultrasonic transducer may be selected as the modulation element and modulation frequencies may be in the MHz range.


The elongate shaft 14 may extend distally from a proximal end 24 to a distal end configured to be advanced within a body lumen to a desired treatment region. The proximal end 24 of the elongate shaft 14 may include a hub (not explicitly shown) attached thereto for connecting other treatment devices or providing a port for facilitating other treatments. It is contemplated that the stiffness of the elongated shaft 14 may be modified to form modulation system 10 for use in various vessel diameters and various locations within the vascular tree. To this end, the material used for manufacturing the elongated shaft 14 may include any suitable biocompatible material such as, but are not limited to, polymers, metals, alloys, either in combination or alone. The material employed may have enough stiffness for use in various lumen diameters, and sufficient flexibility to maneuver through tortuous and/or stenotic lumens, avoiding any undesirable tissue injuries.


The elongate shaft 14 may further include one or more lumens extending therethrough. For example, the elongate shaft 14 may include a guidewire lumen and/or one or more auxiliary lumens. The lumens may be configured in any way known in the art. For example, the guidewire lumen may extend the entire length of the elongate shaft 14 such as in an over-the-wire catheter or may extend only along a distal portion of the elongate shaft 14 such as in a single operator exchange (SOE) catheter. These examples are not intended to be limiting, but rather examples of some possible configurations. While not explicitly shown, the modulation system 10 may further include temperature sensors/wire, an infusion lumen, radiopaque marker bands, fixed guidewire tip, a guidewire lumen, external sheath and/or other components to facilitate the use and advancement of the system 10 within the vasculature.


While not explicitly shown, the modulation system 10 may be include one or more ablation electrode(s) disposed on the outer surface of the elongate shaft 14 adjacent to the distal end region. However, the ablation electrode(s) may be placed at any longitudinal location along the elongate shaft 14 desired. It is further contemplated that in some embodiments, the modulation system 10 may include one or more positioning elements, such as an inflatable balloon or expandable basket, positioned adjacent the distal end the elongate shaft 14 to assist in orienting the one or more electrode(s). In some instances, the ablation electrode(s) may be positioned on a surface of the one or more positioning elements. It is contemplated that ablation electrode(s) may be positioned on an exterior surface of an inflatable balloon or on the framework of an expandable basket. In other instances, the ablation electrode(s) may be positioned within an inflatable balloon, such as on an elongate shaft extending therethough or on an interior surface.


It is contemplated that the modulation system 10 may include any number of ablation electrode(s) desired, such as, but not limited to, one, two, three, four, or more. If multiple ablation electrode(s) are provided, the ablation electrode(s) may be longitudinally, radially and/or circumferentially spaced as desired. In some instances, the ablation electrode may be a circumferential electrode extending around the outer perimeter of the elongate shaft 14. A circumferential electrode may allow for circumferential ablation while reducing and/or eliminating the need for circumferential repositioning of the electrode and/or elongate shaft 14. In some embodiments, the ablation electrode may not extend all the way around the perimeter of the elongate shaft 14. It is contemplated that multiple ablation electrode(s) may be circumferentially positioned around the perimeter of the elongate shaft 14 to reduce and/or eliminate the need to circumferentially reposition the elongate shaft 14 to perform 360° ablation.


The ablation electrode(s) may be connected to the control unit 18 by an insulated electrical conductor, such as element 12 shown in FIG. 1. Once the modulation system 10 has been advanced to the treatment region, energy may be supplied to the ablation electrode(s). The amount of energy delivered to the ablation electrode may be determined by the desired treatment as well as the feedback obtained from the system 10. The power level and duration of the ablation may be adjusted accordingly based on the impedance of the tissue. For example, more energy may result in a larger, deeper lesion. As voltage is applied to the ablation electrode current may pass through tissue proximate the treatment region and additional body tissue between the treatment region and the skin to the skin-contact ground pads 22a-d. While the ground pads 22a-d are illustrated as being positioned on a single side (either posterior or anterior) of the body, it is contemplated that the ground pads may be positioned on either or both sides of the body, as desired. While the system 10 is illustrated as including four ground pads 22a-d, it is contemplated that there may be fewer than four or more than four ground pads as desired. In some instances, it is contemplated that the system 10 may include eight or more ground pads. For example, in some embodiments, the system 10 may include four ground pads positioned on the posterior side of the body and four ground pads positioned on the anterior side of the body. The ground pads may be evenly distributed about the desired treatment region. In some instances, two ground pads may be placed on the upper torso on the anterior side and two ground pads may be placed on the lower torso on the anterior side. Similarly, two ground pads may be placed on the upper torso on the posterior side and two ground pads may be placed on the lower torso on the posterior side. However, this arrangement is merely exemplary. It is contemplated that any number of ground pads may be arranged in any suitable manner for the desired treatment.


The body tissue may comprise adventitia and connective tissues, nerves, fat, fluid, etc. in addition to the muscular vessel wall. Each pad 22a, 22b, 22c, 22d may have a given impedance to complete the electrical circuit and each pad's impedance may differ based upon the tissue types which exist between the treatment region and the grounding (pad) location. Each ground pad 22a, 22b, 22c, 22d may be connected to individual channels of a processor or processing unit 20 through separate electrical conductors 26a, 26b, 26c, 26d. In some instances, the processor 20 may be electrically connected to or otherwise in communication with the power unit 18 via a grounding channel out 28. As each pad 22a, 22b, 22c, 22d may be individually connected to a separate grounding in channels of the processor 20, the resistance of the electrical connections 26a, 26b, 26c, 26d may be individually adjusted. For example, it is contemplated that each channel may include a separate variable resistor for individually adjusting each individual circuit. It is contemplated that the processor 20 may include any number of channels desired such that the electrical connections between the processor 20 and the ground pads 22a-d may be individually adjusted.


As noted above each ground pad 22a, 22b, 22c, 22d may have a certain impedance to complete the circuit (e.g. the path between the ablation electrode disposed within the body and the ground pad located on an exterior surface of the body). As current follows the path of least resistance, it is contemplated that current will preferentially travel between the ablation electrode and the ground pad that has the least amount of impedance to complete the circuit. As such, inconsistent or unintended lesions may occur. This may result in variability in lesion size and depth between treatment locations and from patient to patient. It is contemplated that once connected, the processor 20 may increase the impedance of all circuits to an identical level such that current is evenly distributed between the ablation electrode and the ground pads 22a-d. An illustrative, but non-limiting, example is given in Table 1 below. The impedance given for each ground pad is merely exemplary and is not intended to be limiting in any manner or indicative of actual impedance between the treatment region and the illustrated position of the pad.












TABLE 1







Impedance (Initial)
Impedance (Post Processing)


















Pad 1 (22a)
 97 Ω
145 Ω


Pad 2 (22b)
145 Ω
145 Ω


Pad 3 (22c)
123 Ω
145 Ω


Pad 4 (22d)
111 Ω
145 Ω










The values in the “Impedance (Initial)” column are the impedance values as they may naturally occur while the values in the “Impedance (Post Processing)” column are the impedance values after the processor 20 has adjusted the impedance of the individual circuits. As can be seen, prior to processing, the impedance between each ground pad 22a, 22b, 22c, 22d and the ablation electrode is different for each ground pad 22a, 22b, 22c, 22d. Without any adjustments, it is contemplated that the lowest impedance pathway (e.g. in this example, between bond pad 22a and the ablation electrode) may draw current in the direction of pad 22a. However, the processor 20 may be used to increase the circuit impedance for pads 22a, 22c, 22d to be equivalent to pad 22b. It is contemplated that the processor 20 may electronically add impedance to the circuit by varying the resistance between the ground pad and the processor 20 such that current is evenly distributed between the ablation electrode and the ground pads 22a-d. For example, the energy may travel spherically from the ablation electrode. In some instances, the processor 20 may use a number of variable resistors to add impedance to the circuits. It is further contemplated that the circuit impedance may be further manipulated by repositioning the ground pads 22a, 22b, 22c or 22d. In some instances, the ground pads 22a-d may be strategically located on a patient's body to control the direction of current flow. As the current path can be manipulated based on the impedance of the circuit, the location of the ground pads 22a-d or a combination of the impedance and the location of the ground pads 22a-d, the size and shape of a lesion may be more readily controlled thus reducing and/or eliminating unintended lesions.


In some embodiments, the processor 20 may automatically balance and/or adjust the impedance of the circuits prior to applying power and/or during the ablation procedure. It is contemplated that in some instances, the impedance will not be allowed to automatically adjust once the power has been applied to the ablation electrode. However, the impedance between the ablation electrode and the ground pads 22a-d may be monitored during the ablation procedure. It is contemplated that the modulation system 10 may include set point limits for the ablation procedure variables, such as but not limited to power and temperature. For example, in some instances, the power supplied by the power unit 18 may not exceed a predetermined threshold and/or the power unit may include a control algorithm to maintain the temperature of the target region from exceeding a predetermined threshold temperature.


It is further contemplated that a modulation system 10 that utilizes multiple ablation electrodes powered by a single power source may experience variability in the impedance of each ablation or active electrode. Such variability in the impedance of the ablation electrodes may result in variability of the lesion size and/or depth from each electrode. Providing multiple ground locations, such as ground pads 22a-d, each with modulated impedance, may draw current/power more evenly through each ablation electrode. For example, the energy may travel spherically from the ablation electrode. Manipulation of the current paths may reduce variability in the lesion size and depth resulting in more consistent lesions at the treatment site.


In some embodiments, when multiple active or ablation electrodes are provided at or near the distal end of element 12, the system the system 10 may be operated in a bipolar mode. In this instance, two (or more) electrodes disposed at the treatment location may be 180° out of phase such that one electrode acts as the ground electrode (e.g. one cathode and one anode). It is contemplated that the processor 20 may automatically balance and/or adjust the impedance of the circuits prior to applying power in a similar manner as described above. For example, the processor 20 may electronically add impedance to circuits, as necessary, by varying the resistance between the active electrode functioning as the ground electrode and the processor 20 such that current is evenly distributed between the ablation electrodes and ground electrodes.


The modulation system 10 may be advanced through the vasculature in any manner known in the art. For example, system 10 may include a guidewire lumen to allow the system 10 to be advanced over a previously located guidewire. In some embodiments, the modulation system 10 may be advanced, or partially advanced, within a guide sheath such as the sheath 16. Once the ablation electrode(s) of the modulation system 10 have been placed adjacent to the desired treatment area, positioning mechanisms may be deployed, such as centering baskets, if so provided.


Once the modulation system 10 has been advanced to the treatment region, energy may be supplied to the ablation electrode(s). The amount of energy delivered to the ablation electrode(s) may be determined by the desired treatment as well as the feedback provided by the system 10. As the energy is supplied to the electrode(s), the processing unit 20 may analyze the impedance of the circuits formed by each ground pad 22a, 22b, 22c, 22d. The processing unit 20 may then add impedance to one or more circuits such that all circuits have the same impedance. It is contemplated that as ablation of desired treatment region progresses, the impedance of the circuits may change due to the formation of a lesion. Thus, the processor 20 may be configure to continuously adjust the resistance of each of the circuits formed between the ablation electrode(s) and the ground pads 22a, 22b, 22c, 22d throughout the duration of the ablation procedure. In some instances, the processor 20 may be configured to adjust the resistance of the each of the circuits at predefined time intervals.


In some instances, the elongated shaft 14 may be rotated and additional ablation can be performed at multiple locations around the circumference of the vessel. In some instances, a slow automated “rotisserie” rotation can be used to work around the circumference of the vessel, or a faster spinning can be used to simultaneously ablate around the entire circumference. The spinning can be accomplished with a micro-motor or by spinning a drive shaft. The number of times the elongated shaft 14 is rotated at a given longitudinal location may be determined by the number and size of the ablation electrode(s) present. Once a particular location has been ablated, it may be desirable to perform further ablation procedures at different longitudinal locations. Once the elongated shaft 14 has been longitudinally repositioned, energy may once again be delivered to the ablation electrode(s). If necessary, the elongated shaft 14 may be rotated to perform ablation around the circumference of the vessel at each longitudinal location. This process may be repeated at any number of longitudinal locations desired. It is contemplated that in some embodiments, the system 10 may include ablation electrode(s) at various positions along the length of the modulation system 10 such that a larger region may be treated without longitudinal displacement of the elongated shaft 14.



FIG. 2 is a schematic view of another illustrative renal nerve modulation system 100 in situ. System 100 may be similar in form and function to other modulation systems discussed herein. System 100 may include an element 112 for providing power to a nerve modulation element disposed about and/or within a central elongate shaft 114 and, optionally, within a sheath 116. A proximal end of element 112 may be connected to a control and power element 18, which supplies the necessary electrical energy to activate the one or more modulation elements or electrode(s) at or near a distal end of the element 112. When suitably activated, the electrode(s) are capable of ablating tissue. In some instances, one or more return electrode patches 122a, 122b, (collectively 122a-b) may be supplied on the patient's body to complete the circuit. In some instances, a first return electrode 122a may be supplied on the posterior side 102a of the patient's body while a second return electrode 122b may be supplied on the anterior side 102b of the patient's body.


The control and power element 118 may include monitoring elements to monitor parameters such as power, temperature, voltage, pulse size, and/or shape and other suitable parameters as well as suitable controls for performing the desired procedure. In some instances, the power element 118 may control a radio frequency (RF) ablation electrode and/or one or more sensing electrode(s). It is contemplated that more than one power element 118 may be provided. The ablation electrode may be configured to operate at a frequency of approximately 460 kHz. It is contemplated that any desired frequency in the RF range may be used, for example, from 100-500 kHz. However, it is contemplated that different types of energy outside the RF spectrum may be used as desired, for example, but not limited to ultrasound, microwave, and laser to perform the ablation. While the term ablation electrode is used herein, it is contemplated that the modulation element and modulation frequency may be selected according to the energy used to perform the ablation. For example, when ultrasound energy is used, an ultrasonic transducer may be selected as the modulation element and modulation frequencies may be in the MHz range.


The elongate shaft 114 may extend distally from a proximal end 124 to a distal end configured to be advanced within a body lumen to a desired treatment region. The proximal end 124 of the elongate shaft 114 may include a hub (not explicitly shown) attached thereto for connecting other treatment devices or providing a port for facilitating other treatments. It is contemplated that the stiffness of the elongate shaft 114 may be modified to form a modulation system 100 for use in various vessel diameters and various locations within the vascular tree. The elongate shaft 114 may further include one or more lumens extending therethrough. For example, the elongate shaft 114 may include a guidewire lumen and/or one or more auxiliary lumens. The lumens may be configured in any way known in the art. While not explicitly shown, the modulation system 100 may further include temperature sensors/wire, an infusion lumen, radiopaque marker bands, fixed guidewire tip, a guidewire lumen, external sheath and/or other components to facilitate the use and advancement of the system 100 within the vasculature.


While not explicitly shown, the modulation system 100 may be include one or more ablation electrode(s) disposed on the outer surface of the elongate shaft 114 adjacent to the distal end region. However, the ablation electrode(s) may be placed at any longitudinal location along the elongate shaft 114 desired. It is further contemplated that in some embodiments, the modulation system 100 may include one or more positioning elements, such as an inflatable balloon or expandable basket, positioned adjacent the distal end the elongate shaft 114 to assist in orienting the one or more electrode(s). In some instances, the ablation electrode(s) may be positioned on a surface of the one or more positioning elements. It is contemplated that ablation electrode(s) may be positioned on an exterior surface of an inflatable balloon or on the framework of an expandable basket. In other instances, the ablation electrode(s) may be positioned within an inflatable balloon, such as on an elongate shaft extending therethough or on an interior surface.


It is contemplated that the modulation system 100 may include any number of ablation electrode(s) desired, such as, but not limited to, one, two, three, four, or more. If multiple ablation electrode(s) are provided, the ablation electrode(s) may be longitudinally, radially and/or circumferentially spaced as desired. In some instances, the ablation electrode may be a circumferential electrode extending around the outer perimeter of the elongate shaft 114. A circumferential electrode may allow for circumferential ablation while reducing and/or eliminating the need for circumferential repositioning of the electrode and/or elongate shaft 114. In some embodiments, the ablation electrode may not extend all the way around the perimeter of the elongate shaft 114. It is contemplated that multiple ablation electrode(s) may be circumferentially positioned around the perimeter of the elongate shaft 114 to reduce and/or eliminate the need to circumferentially reposition the elongate shaft 114 to perform 360° ablation.


The ablation electrode(s) may be connected to the control unit 118 by an insulated electrical conductor, such as element 112 shown in FIG. 2. Once the modulation system 100 has been advanced to the treatment region, energy may be supplied to the ablation electrode(s). The amount of energy delivered to the ablation electrode may be determined by the desired treatment as well as the feedback obtained from the system 100. The power level and duration of the ablation may be adjusted accordingly based on the impedance of the tissue. For example, more energy may result in a larger, deeper lesion. As voltage is applied to the ablation electrode, current may pass through tissue proximate the treatment region and additional body tissue between the treatment region and the skin to the skin-contact ground pads 122a-b.


While the ground pads 122a-b are illustrated as being positioned on opposite sides (e.g. posterior and anterior) of the body, it is contemplated that the ground pads may be positioned on either or both sides of the body, as desired. While the system 100 is illustrated as including two ground pads 122a-b, it is contemplated that there may be fewer than two or more than two ground pads as desired. In some embodiments, the system 100 may include one, two, three, four or more ground pads positioned on each side 102a, 102b of the body. In some instances, while not explicitly shown, the ground pads 122a-b may be evenly distributed about the desired treatment region. However, it is contemplated that any number of ground pads may be arranged in any suitable manner for the desired treatment.


The body tissue may comprise adventitia and connective tissues, nerves, fat, fluid, etc. in addition to the muscular vessel wall. Each pad 122a, 122b may have a given impedance to complete the electrical circuit and each pad's impedance may differ based upon the tissue types which exist between the treatment region and the grounding (pad) location. Each ground pad 122a, 122b may be connected to individual channels of a processor or processing unit 120 through separate electrical conductors 126a, 126b to create individual circuits. In some instances, the processor 120 may be electrically connected to or otherwise in communication with the power unit 118 via a grounding channel out 128. As each pad 122a, 122b may be individually connected to separate grounding in channels of the processor 120, the resistance of the electrical connections 126a, 126b may be individually adjusted. For example, it is contemplated that each channel may include a separate variable resistor for individually adjusting each individual circuit. It is contemplated that the processor 120 may include any number of channels desired such that the electrical connections between the processor 120 and the ground pads 122a-b may be individually adjusted.


As noted above each ground pad 122a, 122b may have a certain impedance to complete the circuit (e.g. the path between the ablation electrode disposed within the body and the ground pad located on an exterior surface of the body). As current follows the path of least resistance, it is contemplated that current will preferentially travel between the ablation electrode and the ground pad that has the least amount of impedance to complete the circuit. As such, inconsistent or unintended lesions may occur. This may result in variability in lesion size and depth between treatment locations and from patient to patient. It is contemplated that once connected, the processor 120 may increase the impedance of all circuits to an identical level such that current is evenly distributed between the ablation electrode and the ground pads 122a-b. For example, the energy may travel spherically from the ablation electrode. The processor 120 may electronically add impedance to the circuit(s) by varying the resistance between the ground pads 122a-b and the processor 120. In some instances, the processor 120 may use a number of variable resistors to add impedance to the circuits. It is further contemplated that the circuit impedance may be further manipulated by repositioning the ground pads 122a, 122b. In some instances, the ground pads 122a-b may be strategically located on a patient's body to control the direction of current flow. As the current path can be manipulated based on the impedance of the circuit, the location of the ground pads 122a-b or a combination of the impedance and the location of the ground pads 122a-b, it is contemplated that the size and shape of a lesion may be more readily controlled thus reducing and/or eliminating unintended lesions.


It is further contemplated that a modulation system 100 that utilizes multiple ablation electrodes powered by a single power source may experience variability in the impedance of each ablation or active electrode. Such variability in the impedance of the ablation electrodes may result in variability of the lesion size and/or depth from each electrode. Providing multiple ground locations, such as ground pads 122a-b, each with modulated impedance, may draw current/power more evenly through each ablation electrode. For example, the energy may travel spherically from the ablation electrode. Manipulation of the current paths may reduce variability in the lesion size and depth resulting in more consistent lesions at the treatment site.


The modulation system 100 may be advanced through the vasculature in any manner known in the art. For example, system 100 may include a guidewire lumen to allow the system 100 to be advanced over a previously located guidewire. In some embodiments, the modulation system 100 may be advanced, or partially advanced, within a guide sheath such as the sheath 116. Once the ablation electrode(s) of the modulation system 100 have been placed adjacent to the desired treatment area, positioning mechanisms may be deployed, such as centering baskets, if so provided.


Once the modulation system 100 has been advanced to the treatment region, energy may be supplied to the ablation electrode(s). The amount of energy delivered to the ablation electrode(s) may be determined by the desired treatment as well as the feedback provided by the system 100. As the energy is supplied to the electrode(s), the processing unit 120 may analyze the impedance of the circuits formed by each ground pad 122a, 122b. The processing unit 120 may then add impedance to one or more circuits such that all circuits have the same impedance. It is contemplated that as ablation of desired treatment region progresses, the impedance of the circuits may change due to the formation of a lesion. Thus, the processor 120 may be configure to continuously adjust the resistance of each of the circuits formed between the ablation electrode(s) and the ground pads 122a, 122b throughout the duration of the ablation procedure. In some instances, the processor 120 may be configured to adjust the resistance of the each of the circuits at predefined time intervals.


In some instances, the elongated shaft 114 may be rotated and additional ablation can be performed at multiple locations around the circumference of the vessel. In some instances, a slow automated “rotisserie” rotation can be used to work around the circumference of the vessel, or a faster spinning can be used to simultaneously ablate around the entire circumference. The spinning can be accomplished with a micro-motor or by spinning a drive shaft. The number of times the elongated shaft 114 is rotated at a given longitudinal location may be determined by the number and size of the ablation electrode(s) present. Once a particular location has been ablated, it may be desirable to perform further ablation procedures at different longitudinal locations. Once the elongated shaft 114 has been longitudinally repositioned, energy may once again be delivered to the ablation electrode(s). If necessary, the elongated shaft 114 may be rotated to perform ablation around the circumference of the vessel at each longitudinal location. This process may be repeated at any number of longitudinal locations desired. It is contemplated that in some embodiments, the system 100 may include ablation electrode(s) at various positions along the length of the modulation system 100 such that a larger region may be treated without longitudinal displacement of the elongated shaft 114.



FIG. 3 is a schematic view of another illustrative renal nerve modulation system 200 in situ. System 200 may be similar in form and function to other modulation systems discussed herein. System 200 may include an element 212 for providing power to a nerve modulation element disposed about and/or within a central elongate shaft 214 and, optionally, within a sheath 216. A proximal end of element 212 may be connected to a control and power element 18, which supplies the necessary electrical energy to activate the one or more modulation elements or electrode(s) at or near a distal end of the element 212. When suitably activated, the electrode(s) are capable of ablating tissue. In some instances, one or more return electrode patches 222a, 222b, 222c, 222d, 222e, 222c, 222d, 222e (collectively 222a-e) may be supplied on the patient's body to complete the circuit. In some instances, first and second return electrodes 222a, 222b, 222c, 222d, 222e may be supplied on the posterior side 202a of the patient's body while third and fourth return electrodes 222d, 222e may be supplied on the anterior side 202b of the patient's body. In some instances, a fifth electrode 222c may be supplied on a lateral side of the patient's body such that it is positioned between the posterior 202a and anterior 202b sides. While not explicitly shown, it is contemplated that one or more additional electrodes may also be supplied on the opposite lateral side of the patient's body.


The control and power element 218 may include monitoring elements to monitor parameters such as power, temperature, voltage, pulse size, and/or shape and other suitable parameters as well as suitable controls for performing the desired procedure. In some instances, the power element 218 may control a radio frequency (RF) ablation electrode and/or one or more sensing electrode(s). It is contemplated that more than one power element 218 may be provided. The ablation electrode may be configured to operate at a frequency of approximately 460 kHz. It is contemplated that any desired frequency in the RF range may be used, for example, from 100-500 kHz. However, it is contemplated that different types of energy outside the RF spectrum may be used as desired, for example, but not limited to ultrasound, microwave, and laser to perform the ablation. While the term ablation electrode is used herein, it is contemplated that the modulation element and modulation frequency may be selected according to the energy used to perform the ablation. For example, when ultrasound energy is used, an ultrasonic transducer may be selected as the modulation element and modulation frequencies may be in the MHz range.


The elongate shaft 214 may extend distally from a proximal end 224 to a distal end configured to be advanced within a body lumen to a desired treatment region. The proximal end 224 of the elongate shaft 214 may include a hub (not explicitly shown) attached thereto for connecting other treatment devices or providing a port for facilitating other treatments. It is contemplated that the stiffness of the elongate shaft 214 may be modified to form a modulation system 200 for use in various vessel diameters and various locations within the vascular tree. The elongate shaft 214 may further include one or more lumens extending therethrough. For example, the elongate shaft 214 may include a guidewire lumen and/or one or more auxiliary lumens. The lumens may be configured in any way known in the art. While not explicitly shown, the modulation system 200 may further include temperature sensors/wire, an infusion lumen, radiopaque marker bands, fixed guidewire tip, a guidewire lumen, external sheath and/or other components to facilitate the use and advancement of the system 200 within the vasculature.


While not explicitly shown, the modulation system 200 may be include one or more ablation electrode(s) disposed on the outer surface of the elongate shaft 214 adjacent to the distal end region. However, the ablation electrode(s) may be placed at any longitudinal location along the elongate shaft 214 desired. It is further contemplated that in some embodiments, the modulation system 200 may include one or more positioning elements, such as an inflatable balloon or expandable basket, positioned adjacent the distal end the elongate shaft 214 to assist in orienting the one or more electrode(s). In some instances, the ablation electrode(s) may be positioned on a surface of the one or more positioning elements. It is contemplated that ablation electrode(s) may be positioned on an exterior surface of an inflatable balloon or on the framework of an expandable basket. In other instances, the ablation electrode(s) may be positioned within an inflatable balloon, such as on an elongate shaft extending therethough or on an interior surface.


It is contemplated that the modulation system 200 may include any number of ablation electrode(s) desired, such as, but not limited to, one, two, three, four, or more. If multiple ablation electrode(s) are provided, the ablation electrode(s) may be longitudinally, radially and/or circumferentially spaced as desired. In some instances, the ablation electrode may be a circumferential electrode extending around the outer perimeter of the elongate shaft 214. A circumferential electrode may allow for circumferential ablation while reducing and/or eliminating the need for circumferential repositioning of the electrode and/or elongate shaft 214. In some embodiments, the ablation electrode may not extend all the way around the perimeter of the elongate shaft 214. It is contemplated that multiple ablation electrode(s) may be circumferentially positioned around the perimeter of the elongate shaft 214 to reduce and/or eliminate the need to circumferentially reposition the elongate shaft 214 to perform 360° ablation.


The ablation electrode(s) may be connected to the control unit 218 by an insulated electrical conductor, such as element 212 shown in FIG. 2. Once the modulation system 200 has been advanced to the treatment region, energy may be supplied to the ablation electrode(s). The amount of energy delivered to the ablation electrode may be determined by the desired treatment as well as the feedback obtained from the system 200. The power level and duration of the ablation may be adjusted accordingly based on the impedance of the tissue. For example, more energy may result in a larger, deeper lesion. As voltage is applied to the ablation electrode, current may pass through tissue proximate the treatment region and additional body tissue between the treatment region and the skin to the skin-contact ground pads 222a-e.


While the ground pads 222a-e are illustrated as being positioned on multiple sides (e.g. posterior, anterior, and lateral) of the body, it is contemplated that the ground pads 222a-e may be positioned on each side (posterior, anterior, or lateral) individually or the ground pads 222a-e may be positioned on any combination of the posterior, anterior, and lateral sides, as desired. While the system 200 is illustrated as including five ground pads 222a-e, it is contemplated that there may be fewer than five or more than five ground pads as desired. In some embodiments, the system 200 may include one, two, three, four or more ground pads positioned on each side (posterior, anterior, or lateral) of the body. While not explicitly shown, it is contemplated that one or more additional electrodes may also be supplied on the opposite lateral side of the patient's body. It is contemplated that placing additional ground pads on a lateral side of the body may allow for more even current distribution by drawing current in additional directions. In some instances, while not explicitly shown, the ground pads 222a-e may be evenly distributed about the desired treatment region(s). However, it is contemplated that any number of ground pads may be arranged in any suitable manner for the desired treatment.


In some instances, the distribution of the ground pads 222a-e may be selected to allow for a zone control option. For example, if nerve ablation is desired on both the right and left renal arteries, it may be desirable to have ground pads positioned on both lateral sides of the body in addition to the anterior and posterior sides. During ablation of the right renal nerves, ground pads on the right lateral side of the body may be activated in addition to any ground pads on the anterior and/or posterior sides while ground pads on the left lateral side of the body remain inactive. Similarly, the during ablation of the left renal nerves, ground pads on the left lateral side of the body may be activated in addition to any ground pads on the anterior and/or posterior sides while ground pads on the right lateral side of the body remain inactive. The processor 220 may include a feedback loop to allow for selection between multiple treatment zones. However, it is contemplated that the ground pads may be assigned zones based on the desired treatment, and the system 200 is not intended to be limited to the example zones provided.


The body tissue may comprise adventitia and connective tissues, nerves, fat, fluid, etc. in addition to the muscular vessel wall. Each pad 222a, 222b, 222c, 222d, 222e may have a given impedance to complete the electrical circuit and each pad's impedance may differ based upon the tissue types which exist between the treatment region and the grounding (pad) location. Each ground pad 222a, 222b, 222c, 222d, 222e may be connected to individual channels of a processor or processing unit 220 through separate electrical conductors 226a, 226b, 226c, 226d, 226e to create individual circuits. In some instances, the processor 220 may be electrically connected to or otherwise in communication with the power unit 218 via a grounding channel out 228. As each pad 222a, 222b, 222c, 222d, 222e may be individually connected to separate grounding in channels of the processor 220, the resistance of the electrical connections 226a, 226b, 226c, 226d, 226e may be individually adjusted. For example, it is contemplated that each channel may include a separate variable resistor for individually adjusting each individual circuit. It is contemplated that the processor 220 may include any number of channels desired such that the electrical connections between the processor 220 and the ground pads 222a-e may be individually adjusted. Further, the processor 220 may be configured to disconnect one or more ground pads 222a-e from the circuit such that the ground pads 222a-e may be activated as desired, such as to create zone control.


As noted above each ground pad 222a, 222b, 222c, 222d, 222e may have a certain impedance to complete the circuit (e.g. the path between the ablation electrode disposed within the body and the ground pad located on an exterior surface of the body). As current follows the path of least resistance, it is contemplated that current will preferentially travel between the ablation electrode and the ground pad that has the least amount of impedance to complete the circuit. As such, inconsistent or unintended lesions may occur. This may result in variability in lesion size and depth between treatment locations and from patient to patient. It is contemplated that once connected, the processor 220 may increase the impedance of all circuits to an identical level such that current is evenly distributed between the ablation electrode and the ground pads 222a-e. For example, the energy may travel spherically from the ablation electrode. The processor 220 may electronically add impedance to the circuit(s) by varying the resistance between the ground pads 222a-e and the processor 220. In some instances, the processor 220 may use a number of variable resistors to add impedance to the circuits. It is further contemplated that the circuit impedance may be further manipulated by repositioning the ground pads 222a, 222b, 222c, 222d, 222e. In some instances, the ground pads 222a-e may be strategically located on a patient's body to control the direction of current flow. As the current path can be manipulated based on the impedance of the circuit, the location of the ground pads 222a-e or a combination of the impedance and the location of the ground pads 222a-e, it is contemplated that the size and shape of a lesion may be more readily controlled thus reducing and/or eliminating unintended lesions.


It is further contemplated that a modulation system 200 that utilizes multiple ablation electrodes powered by a single power source may experience variability in the impedance of each ablation or active electrode. Such variability in the impedance of the ablation electrodes may result in variability of the lesion size and/or depth from each electrode. Providing multiple ground locations, such as ground pads 222a-e, each with modulated impedance, may draw current/power more evenly through each ablation electrode. For example, the energy may travel spherically from the ablation electrode. Manipulation of the current paths may reduce variability in the lesion size and depth resulting in more consistent lesions at the treatment site.


The modulation system 200 may be advanced through the vasculature in any manner known in the art. For example, system 200 may include a guidewire lumen to allow the system 200 to be advanced over a previously located guidewire. In some embodiments, the modulation system 200 may be advanced, or partially advanced, within a guide sheath such as the sheath 216. Once the ablation electrode(s) of the modulation system 200 have been placed adjacent to the desired treatment area, positioning mechanisms may be deployed, such as centering baskets, if so provided.


Once the modulation system 200 has been advanced to the treatment region, energy may be supplied to the ablation electrode(s). The amount of energy delivered to to the ablation electrode(s) may be determined by the desired treatment as well as the feedback provided by the system 200. As the energy is supplied to the electrode(s), the processing unit 220 may analyze the impedance of the circuits formed by each ground pad 222a, 222b, 222c, 222d, 222e. The processing unit 220 may then add impedance to one or more circuits such that all circuits have the same impedance. It is contemplated that as ablation of desired treatment region progresses, the impedance of the circuits may change due to the formation of a lesion. Thus, the processor 220 may be configure to continuously adjust the resistance of each of the circuits formed between the ablation electrode(s) and the ground pads 222a, 222b, 222c, 222d, 222e throughout the duration of the ablation procedure. In some instances, the processor 220 may be configured to adjust the resistance of the each of the circuits at predefined time intervals.


In some instances, the elongated shaft 214 may be rotated and additional ablation can be performed at multiple locations around the circumference of the vessel. In some instances, a slow automated “rotisserie” rotation can be used to work around the circumference of the vessel, or a faster spinning can be used to simultaneously ablate around the entire circumference. The spinning can be accomplished with a micro-motor or by spinning a drive shaft. The number of times the elongated shaft 214 is rotated at a given longitudinal location may be determined by the number and size of the ablation electrode(s) present. Once a particular location has been ablated, it may be desirable to perform further ablation procedures at different longitudinal locations. Once the elongated shaft 214 has been longitudinally repositioned, energy may once again be delivered to the ablation electrode(s). If necessary, the elongated shaft 214 may be rotated to perform ablation around the circumference of the vessel at each longitudinal location. This process may be repeated at any number of longitudinal locations desired. It is contemplated that in some embodiments, the system 200 may include ablation electrode(s) at various positions along the length of the modulation system 200 such that a larger region may be treated without longitudinal displacement of the elongated shaft 214.


Those skilled in the art will recognize that the present invention may be manifested in a variety of forms other than the specific embodiments described and contemplated herein. Accordingly, departure in form and detail may be made without departing from the scope and spirit of the present invention as described in the appended claims.

Claims
  • 1. A method for performing intravascular nerve modulation at a target region in a lumen of a subject using a nerve modulation system comprising: an elongate shaft having a proximal end region and a distal end region; one or more ablation electrodes positioned adjacent the distal end region of the elongate shaft; two or more ground pads; a control unit electrically coupled to the one or more ablation electrodes; and a processor electrically coupled to the two or more ground pads; the method comprising: positioning the two or more ground pads on a surface of a body of the subject at locations distributed about the target region, thereby controlling a direction of current flow between the one or more ablation electrodes and each of the two or more ground pads;advancing the distal end region through the lumen such that the distal end region is adjacent to the target region;applying a voltage to the one or more ablation electrodes, wherein current flows between the one or more ablation electrodes and each of the two or more ground pads to form individual circuits;monitoring the impedance of each of the individual circuits; andadjusting the resistance of at least one of the individual circuits such that each of the individual circuits has approximately the same impedance.
  • 2. The method of claim 1, wherein the impedance of each circuit is variable.
  • 3. The method of claim 1, wherein adjusting the resistance of at least one of the circuits comprises adding resistance to the at least one circuit.
  • 4. The method of claim 3, wherein the processor electronically adds resistance to the circuit.
  • 5. The method of claim 1, wherein current flow is evenly distributed between the one or more ablation electrodes and the two or more ground pads.
  • 6. The method of claim 1, wherein current flows spherically from the one or more ablation electrodes.
  • 7. The method of claim 1, wherein the two or more ground pads are evenly distributed about the desired treatment region.
  • 8. An intravascular nerve modulation system comprising: an elongate shaft having a proximal end region and a distal end region;an ablation electrode positioned adjacent the distal end region of the elongate shaft;a plurality of ground pads;a control unit electrically coupled to the ablation electrode and configured to apply a voltage to the ablation electrode such that energy flows between the ablation electrode and each of the plurality of ground pads, thereby forming a plurality of individual circuits; anda processor electrically coupled to each of the plurality of ground pads;wherein the processor is configured to monitor an impedance of each of the individual circuits; andwherein the processor is configured to modulate a resistance of each of the individual circuits such that each circuit has approximately the same impedance.
  • 9. The intravascular nerve modulation system of claim 8, further comprising an additional ablation electrode.
  • 10. The intravascular nerve modulation system of claim 8, wherein the at least two ground pads includes a first ground pad and a second ground pad, and wherein the first ground pad is configured to be positioned on a subject's adjacent a first side of a desired treatment location and the second ground pad is configured to be positioned in the subject's body adjacent a second side of the desired treatment location.
  • 11. A method for performing intravascular nerve modulation at a desired treatment location in a body of a subject using a nerve modulation system comprising: an elongate shaft having a proximal end region and a distal end region; an ablation electrode positioned adjacent the distal end region of the elongate shaft; a plurality of ground pads; a control unit electrically coupled to the ablation electrode and configured to apply a voltage to the ablation electrode such that current flows between the ablation electrode and each of the plurality of ground pads, thereby forming a plurality of individual circuits; and a processor electrically coupled to each of the plurality of ground pads; wherein the processor is configured to monitor an impedance of each of the individual circuits; and wherein the processor is configured to modulate a resistance of each of the individual circuits such that each circuit has approximately the same impedance; the method comprising: advancing the distal end region through the lumen such that the distal end region is adjacent to the treatment location;positioning a first ground pad of the plurality of ground pads on a surface of the subject's body adjacent a first side of the desired treatment location and positioning a second ground pad of the plurality of ground pads on the surface of the subject's body adjacent a second side of the desired treatment location thereby controlling a direction of current flow between the ablation electrode and the plurality of ground electrodes;applying a voltage to the ablation electrode, wherein current flows between the ablation electrode and each of the plurality of ground pads to form a plurality of individual circuits;monitoring the impedance of each of the individual circuits; andmodulating the resistance of at least one of the individual circuits such that each of the individual circuits has approximately the same impedance.
  • 12. The method of claim 11, wherein the first ground pad is positioned on an anterior side of the subject's body and wherein the second ground pad is positioned on a posterior side of the subject's body.
  • 13. The method of claim 12, (a) wherein the desired treatment location is in the left renal artery and wherein the method further comprises positioning a third ground pad of the plurality of ground pads on a left lateral side of the subject's body and/or (b) wherein the desired treatment location is in the right renal artery and wherein the method further comprises positioning a fourth ground pad of the plurality of ground pads on a right lateral side of the subject's body.
  • 14. The method of claim 11, wherein the method is a method for performing intravascular renal nerve modulation and wherein method comprises positioning the first ground pad and a third ground pad of the plurality of ground pads on an anterior side of the subject's body, positioning the second ground pad and a fourth ground pad of the plurality of ground pads on a posterior side of the subject's body, and positioning a fifth ground pad of the plurality of ground pads on a lateral side of the subject's body.
  • 15. The method of claim 11, wherein the method is a method for performing intravascular renal nerve modulation and wherein method comprises positioning the first ground pad and a third ground pad of the plurality of ground pads on an anterior side of an upper torso of the subject's body, positioning the second ground pad and a fourth ground pad of the plurality of ground pads on the anterior side of a lower torso of the subject's body, positioning a fifth ground pad and sixth ground pad of the plurality of ground pads on a posterior side of the upper torso of the subject's body, and positioning a seventh ground pad and an eight ground pad of the plurality of ground pads on the posterior side of the lower torso of the subject's body.
  • 16. The method of claim 11, wherein the processor automatically modulates the resistance of at least one of the individual circuits such that each of the individual circuits has approximately the same impedance.
  • 17. The method of claim 16, wherein the resistance of at least one of the individual circuits is automatically modulated both prior to and during intravascular nerve modulation.
  • 18. The method of claim 16, wherein the resistance of at least one of the individual circuits is automatically modulated prior to, but not during, intravascular nerve modulation.
CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims priority under 35 U.S.C. § 119 to U.S. Provisional Application Ser. No. 61/712,138, filed Oct. 10, 2012, the entirety of which is incorporated herein by reference.

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Related Publications (1)
Number Date Country
20140100562 A1 Apr 2014 US
Provisional Applications (1)
Number Date Country
61712138 Oct 2012 US