Claims
- 1. A chemical compound of the structural formula: ##STR4## in which: R is hydrogen or lower alkyl of 1-3 carbons;
- R.sup.1 is hydrogen, phenyl or phenyl optionally substituted by 1 or 2 hydroxy or methoxy groups;
- R.sup.2 is hydrogen, lower alkyl of 1-3 carbons, phenyl or phenyl optionally substituted by 1 or 2 hydroxy or methoxy groups;
- Y is hydrogen, hydroxy or methoxy;
- X is O or H,H; and
- n and m are each integers of from 0-4; or pharmaceutically acceptable acid addition or alkali metal salts thereof.
- 2. The compound of claim 1 in which X is O.
- 3. The compound of claim 1 in which X is O and R is methyl.
- 4. The compound of claim 1 in which X is O, n is 3, m is O.
- 5. The compound of claim 1 in which X is O, n is 3, m is O and the configuration of the two prolyl units is L.
- 6. The compound of claim 1 being N-4-(4-hydroxyphenyl)-butyryl-L-prolyl-D,L-.alpha.-methylphenylalanyl-glycyl-L-proline.
- 7. The compound of claim 1 being N-4-(4-hydroxyphenyl)-butyryl-L-prolyl-D,L-.alpha.-methyl-3,4-dimethoxyphenylalanyl-glycyl-L-proline.
- 8. The compound of claim 1 being N-4-(4-hydroxyphenyl)-butyryl-L-prolyl-D-phenylalanyl-glycyl-L-proline.
- 9. The compound of claim 1 being N-4-(4-hydroxyphenyl)-butyryl-L-prolyl-L-phenylalanyl-glycyl-L-proline or its alkali metal salts.
- 10. The compound of claim 1 being N-4-(4-hydroxyphenyl)-butyryl-L-prolyl-D,L-.alpha.-methyltyranosyl-glycyl-L-proline.
- 11. The method of improving kidney function in a subject in need thereof comprising administering orally or parenterally to said subject a nontoxic, therapeutically effective quantity of a compound of claims 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.
- 12. The pharmaceutical composition effective for improving kidney function comprising a nontoxic, therapeutically effective quantity of a compound of claims 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 and a carrier therefor.
Parent Case Info
This application is a continuation-in-part of U.S. patent application Ser. No. 349,448 filed Feb. 17, 1982.
Foreign Referenced Citations (1)
Number |
Date |
Country |
2943582 |
May 1980 |
DEX |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
349448 |
Feb 1982 |
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