Claims
- 1. A peptide of the formula
- ACYL--X--Y--W--U--V (I)
- or a pharmaceutically acceptable acid addition salt thereof, wherein
- ACYL is BOC, IVA, NVA, DNMA, Z, MNPP, BMA, BBSP, or ##STR411## wherein D is ##STR412## X is absent, PHE, HOMOPHE, NAPHTHYLALA, CYCLOHEXYLALA, O-MeTYR, TYR, or TRP, with the proviso that when ACYL is DNMA, BBSP, MNPP, or ##STR413## wherein n is an integer from 2 to 8, R is hydrogen or an alkyl of from 1 to 3 carbon atoms,
- R.sub.1 and R.sub.2 are each independently hydrogen, lower alkyl of from 1 to 4 carbon atoms, or taken together form a 5 or 6 membered ring with the nitrogen to which they are attached, aralkyl, or aryl,
- R.sub.3 is hydrogen or methyl,
- R.sub.4 is lower alkyl or benzyl,
- R.sub.5 is CH.sub.2 SCH.sub.3, CH.sub.2 SOCH.sub.3, or CH.sub.2 SO.sub.2 CH.sub.3,
- R.sub.6 is R.sub.5, H, or lower alkyl;
- W is STA, PHSTA, CYSTA, ASTA, ACYS, CHSTA, DFSTA, DFKSTA, DFCYS, DFKCYS, DFCHS, or DFKCHS;
- U is absent, LEU, ILE, VAL, N-MeLEU, N-MeILE; and
- V is ##STR414##
- 2. A compound according to claim 1 wherein ACYL is BOC, IVA, DNMA, BMA, BBSP or ##STR415##
- 3. A compound according to claim 1 wherein V is ##STR416##
- 4. A peptide selected from the group consisting of ##STR417##
- 5. A pharmaceutical composition comprising a renin-inhibitory effective amount of a compound as claimed in claim 4 together with a pharmaceutically acceptable carrier.
- 6. A method of treating renin-associated hypertension which comprises administering to a mammal a pharmaceutical composition as claimed in claim 5.
CROSS-REFERENCE
This application is a continuation-in-part of application Ser. No. 113,278 filed Nov. 2, 1987, now abandoned, which is a continuation-in-part of application Ser. No. 945,582 filed Dec. 23, 1986, abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4609641 |
Evans et al. |
Sep 1986 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
0186977 |
May 1986 |
EPX |
Non-Patent Literature Citations (4)
Entry |
Haber et al., J. Cardiovasc. Pharmacol., 1987, 10(Suppl. 7):554-558. |
Burger, Medicinal Chemistry, 1960, pp. 565-571, 578-581, 600-601. |
Denkewalter et al., Progress in Drug Research, vol. 10, 1966, pp. 510-512. |
Plattner et al., J. Med. Chem., 31(12), 1988, pp. 2277-2288. |
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
113278 |
Nov 1987 |
|
Parent |
945582 |
Dec 1986 |
|