Patent Grant
10709552
The present disclosure pertains to medical devices, and methods for manufacturing and/or using medical devices. More particularly, the present disclosure pertains to configurations of a replacement heart valve.
A wide variety of intracorporeal medical devices have been developed for medical use, for example, intravascular use. Some of these devices include guidewires, catheters, medical device delivery systems (e.g., for stents, grafts, replacement valves, etc.), and the like. These devices are manufactured by any one of a variety of different manufacturing methods and may be used according to any one of a variety of methods. Of the known medical devices and methods, each has certain advantages and disadvantages. There is an ongoing need to provide alternative medical devices as well as alternative methods for manufacturing and using medical devices.
In a first aspect, a locking mechanism for a medical implant may comprise a buckle member, a post member axially translatable with respect to the buckle member, the post member including a receiving portion proximate a proximal end of the post member, a distal end, a laterally-arched central body portion extending between the receiving portion and the distal end, and a cantilevered leg extending proximally from the distal end, and an actuator element including a proximal shaft portion and a distal engagement portion, the distal engagement portion being configured to releasably engage the receiving portion of the post member. The proximal shaft portion may be pivotable with respect to the distal engagement portion.
In addition or alternatively, and in a second aspect, the actuator element includes a hinge element disposed between the proximal shaft portion and the distal engagement portion.
In addition or alternatively, and in a third aspect, the post member includes at least one aperture extending therethrough proximate the distal end, the at least one aperture being configured to receive a coupling element therethrough.
In addition or alternatively, and in a fourth aspect, the distal engagement portion includes a lateral protrusion proximate a distal end of the distal engagement portion.
In addition or alternatively, and in a fifth aspect, the lateral protrusion is configured to engage with an aperture disposed within the receiving portion.
In addition or alternatively, and in a sixth aspect, the laterally-arched central body portion includes a tooth extending laterally therefrom.
In addition or alternatively, and in a seventh aspect, the tooth extends toward the cantilevered leg.
In addition or alternatively, and in an eighth aspect, the central body portion arches laterally in a first direction relative to the proximal end and the distal end, and the tooth extends laterally in the first direction from the central body portion.
In addition or alternatively, and in a ninth aspect, the cantilevered leg includes a longitudinally-oriented slot extending therethrough.
In addition or alternatively, and in a tenth aspect, the receiving portion includes a first portion and a second portion configured to splay apart as the post member is translated proximally within the buckle member to release the distal engagement portion therefrom.
In addition or alternatively, and in an eleventh aspect, the buckle member is formed of a substantially rigid material.
In addition or alternatively, and in a twelfth aspect, the central body portion is configured to flex towards a substantially straight configuration upon proximal translation through the buckle member.
In addition or alternatively, and in a thirteenth aspect, a replacement heart valve implant may comprise a tubular anchor member defining a central longitudinal axis; a plurality of locking mechanisms, each locking mechanism comprising a buckle member fixedly attached to the tubular anchor member, and a post member axially translatable with respect to the buckle member, the post member including a receiving portion proximate a proximal end of the post member, a distal end, a laterally-arched central body portion extending between the receiving portion and the distal end, and a cantilevered leg extending proximally from the distal end; a plurality of valve leaflets, wherein each valve leaflet is coupled to the cantilevered leg of at least one of the plurality of locking mechanisms; and a plurality of actuator elements corresponding to the plurality of locking mechanisms, each actuator element including a proximal shaft portion and a distal engagement portion, wherein the proximal shaft portion is pivotable relative to the distal engagement portion, wherein the distal engagement portion is releasably fixed to the receiving portion of one post member.
In addition or alternatively, and in a fourteenth aspect, the buckle member of each locking mechanism is positioned against an inner surface of the tubular anchor member.
In addition or alternatively, and in a fifteenth aspect, the plurality of valve leaflets is configured to shift between an everted position wherein a free end of each of the plurality of valve leaflets is disposed distally of the tubular anchor member, and a deployed position wherein the free end of each of the plurality of valve leaflets is disposed within the tubular anchor member.
In addition or alternatively, and in a sixteenth aspect, in the everted position, each of the plurality of actuator elements extends distally of the tubular anchor member.
In addition or alternatively, and in a seventeenth aspect, each of the plurality of valve leaflets is secured to the tubular anchor member at a secured end opposite the free end.
In addition or alternatively, and in an eighteenth aspect, a replacement heart valve implant may comprise a tubular anchor member defining a central longitudinal axis, the tubular anchor member being configured to shift between a delivery configuration and a deployed configuration; a plurality of locking mechanisms, each locking mechanism comprising a buckle member fixedly attached to the tubular anchor member, and a post member axially translatable with respect to the buckle member, the post member including a receiving portion proximate a proximal end of the post member, a distal end, a laterally-arched central body portion extending from the receiving portion to the distal end, and a cantilevered leg extending proximally from the distal end; a plurality of valve leaflets, wherein each valve leaflet is coupled to the cantilevered leg of at least one of the plurality of locking mechanisms; and a plurality of actuator elements corresponding to the plurality of locking mechanisms, each actuator element including a proximal shaft portion pivotably connected to a distal engagement portion, the distal engagement portion being releasably fixed to the receiving portion of one post member, wherein the distal engagement portion is configured to pivot with respect to the proximal shaft portion in a radial direction relative to the central longitudinal axis.
In addition or alternatively, and in a nineteenth aspect, each actuator element extends through the buckle member of its corresponding locking mechanism when the tubular anchor member is in the delivery configuration, and each actuator element is configured to translate the post member of its corresponding locking mechanism into engagement with the buckle member of its corresponding locking mechanism upon proximal retraction of the plurality of actuator elements.
In addition or alternatively, and in a twentieth aspect, the post member is at least partially disposed distally of the tubular anchor member when the tubular anchor member is in the delivery configuration, and the post member is locked within the buckle member when the tubular anchor member is in the deployed configuration.
The above summary of some embodiments, aspects, and/or examples is not intended to describe each disclosed embodiment or every implementation of the present disclosure. The Figures, and Detailed Description, which follow, more particularly exemplify these embodiments.
The disclosure may be more completely understood in consideration of the following detailed description of various embodiments in connection with the accompanying drawings, in which:
While aspects of the disclosure are amenable to various modifications and alternative forms, specifics thereof have been shown by way of example in the drawings and will be described in detail. It should be understood, however, that the intention is not to limit aspects of the disclosure to the particular embodiments described. On the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the disclosure.
The following description should be read with reference to the drawings, which are not necessarily to scale, wherein like reference numerals indicate like elements throughout the several views. The detailed description and drawings are intended to illustrate but not limit the claimed invention. Those skilled in the art will recognize that the various elements described and/or shown may be arranged in various combinations and configurations without departing from the scope of the disclosure. The detailed description and drawings illustrate example embodiments of the claimed invention.
For the following defined terms, these definitions shall be applied, unless a different definition is given in the claims or elsewhere in this specification.
All numeric values are herein assumed to be modified by the term “about,” whether or not explicitly indicated. The term “about”, in the context of numeric values, generally refers to a range of numbers that one of skill in the art would consider equivalent to the recited value (e.g., having the same function or result). In many instances, the term “about” may include numbers that are rounded to the nearest significant figure. Other uses of the term “about” (e.g., in a context other than numeric values) may be assumed to have their ordinary and customary definition(s), as understood from and consistent with the context of the specification, unless otherwise specified.
The recitation of numerical ranges by endpoints includes all numbers within that range, including the endpoints (e.g. 1 to 5 includes 1, 1.5, 2, 2.75, 3, 3.80, 4, and 5).
Although some suitable dimensions, ranges, and/or values pertaining to various components, features and/or specifications are disclosed, one of skill in the art, incited by the present disclosure, would understand desired dimensions, ranges, and/or values may deviate from those expressly disclosed.
As used in this specification and the appended claims, the singular forms “a”, “an”, and “the” include plural referents unless the content clearly dictates otherwise. As used in this specification and the appended claims, the term “or” is generally employed in its sense including “and/or” unless the content clearly dictates otherwise.
Relative terms such as “proximal”, “distal”, “advance”, “retract”, variants thereof, and the like, may be generally be considered with respect to the positioning, direction, and/or operation of various elements relative to a user/operator/manipulator of the device, wherein “proximal” and “retract” indicate or refer to closer to or toward the user and “distal” and “advance” indicate or refer to farther from or away from the user. Other relative terms, such as “upstream”, “downstream”, “inflow”, and “outflow” refer to a direction of fluid flow within a lumen, such as a body lumen, a blood vessel, or within a device.
It is noted that references in the specification to “an embodiment”, “some embodiments”, “other embodiments”, etc., indicate that the embodiment(s) described may include a particular feature, structure, or characteristic, but every embodiment may not necessarily include the particular feature, structure, or characteristic. Moreover, such phrases are not necessarily referring to the same embodiment. Further, when a particular feature, structure, or characteristic is described in connection with an embodiment, it would be within the knowledge of one skilled in the art to effect such feature, structure, or characteristic in connection with other embodiments, whether or not explicitly described, unless clearly stated to the contrary. That is, the various individual elements described below, even if not explicitly shown in a particular combination, are nevertheless contemplated as being combinable or arrangable with each other to form other additional embodiments or to complement and/or enrich the described embodiment(s), as would be understood by one of ordinary skill in the art.
For the purpose of clarity, certain identifying numerical nomenclature (e.g., first, second, third, fourth, etc.) may be used throughout the description and/or claims to name and/or differentiate between various described and/or claimed features. It is to be understood that the numerical nomenclature is not intended to be limiting and is exemplary only. In some embodiments, alterations of and deviations from previously-used numerical nomenclature may be made in the interest of brevity and clarity. That is, a feature identified as a “first” element may later be referred to as a “second” element, a “third” element, etc. or may be omitted entirely, and/or a different feature may be referred to as the “first” element. The meaning and/or designation in each instance will be apparent to the skilled practitioner.
Diseases and/or medical conditions that impact the cardiovascular system are prevalent in the United States and throughout the world. Traditionally, treatment of the cardiovascular system was often conducted by directly accessing the impacted part of the system. For example, treatment of a blockage in one or more of the coronary arteries was traditionally treated using coronary artery bypass surgery. As can be readily appreciated, such therapies are rather invasive to the patient and require significant recovery times and/or treatments. More recently, less invasive therapies have been developed, for example, where a blocked coronary artery could be accessed and treated via a percutaneous catheter (e.g., angioplasty). Such therapies have gained wide acceptance among patients and clinicians.
Some relatively common medical conditions may include or be the result of inefficiency, ineffectiveness, or complete failure of one or more of the valves within the heart. For example, failure of the aortic valve or the mitral valve can have a serious effect on a human and could lead to serious health condition and/or death if not dealt with. Treatment of defective heart valves poses other challenges in that the treatment often requires the repair or outright replacement of the defective valve. Such therapies may be highly invasive to the patient. Disclosed herein are medical devices that may be used for delivering a medical device to a portion of the cardiovascular system in order to diagnose, treat, and/or repair the system. At least some of the medical devices disclosed herein may be used to deliver and implant a replacement heart valve (e.g., a replacement aortic valve, replacement mitral valve, etc.). In addition, the devices disclosed herein may deliver the replacement heart valve percutaneously and, thus, may be much less invasive to the patient. The devices disclosed herein may also provide a number of additional desirable features and benefits as described in more detail below.
The figures illustrate selected components and/or arrangements of a medical implant system 10, shown schematically in
The medical implant system 10, as seen in
In use, the medical implant system 10 may be advanced percutaneously through the vasculature to a position proximate to an area of interest and/or a treatment location. For example, in some embodiments, the medical implant system 10 may be advanced through the vasculature to a position proximate to a defective native valve (e.g., aortic valve, mitral valve, etc.). Alternative approaches to treat a defective aortic valve and/or other heart valve(s) are also contemplated with the medical implant system 10. During delivery, the medical implant 14 may be generally disposed in an elongated and low profile “delivery” configuration within the delivery system 12. Once positioned, at least a portion of the delivery system 12 may be retracted relative to the medical implant 14 to expose the medical implant 14. In some embodiments, the medical implant 14 may be disposed in an “everted” configuration while disposed within the lumen and/or the distal end of the delivery system 12 and/or immediately upon exposure after retracting the delivery system 12. In some embodiments, the “delivery” configuration and the “everted” configuration may be substantially similar and/or may be used interchangeably. The medical implant 14 may be actuated using the handle 18 in order to translate the medical implant 14 into a generally shortened and larger profile “deployed” configuration suitable for implantation within the anatomy, as seen in
In some embodiments, the delivery system 12 may include at least one lumen extending therethrough. For example, in some embodiments, the delivery system 12 may include a first lumen, a second lumen, a third lumen, and a fourth lumen. Other configurations are also contemplated. In general, the at least one lumen extend along an entire length of the delivery system 12. Other embodiments are contemplated, however, where at least one of the at least one lumen extends along only a portion of the length of the delivery system 12. In some embodiments, a coupler assembly 32 may be attached at and/or to a distal end of the delivery system 12. In some embodiments, the coupler assembly 32 may releasably couple the medical implant 14 and/or selected components thereof to the delivery system 12. In some embodiments, the coupler assembly 32 may include a plurality of fingers, as discussed in more detail below.
In some embodiments, disposed within one of the lumens of the delivery system 12 may be at least one actuator member 50, which may be used to actuate (e.g., translate axially or longitudinally, and/or expand) the medical implant 14 between a delivery configuration and a deployed configuration. In some embodiments, the medical implant system 10 may include at least one actuator member 50. In some embodiments, the at least one actuator member 50 may include a plurality of actuator members 50, two actuator members 50, three actuator members 50, four actuator members 50, or another suitable or desired number of actuator members 50. For the purpose of illustration only, the medical implant system 10 and/or the medical implant 14 of
It is to be noted that in order to facilitate understanding, certain features of the disclosure may be described in the singular, even though those features may be plural or recurring within the disclosed embodiment(s). Each instance of the features may include and/or be encompassed by the singular disclosure(s), unless expressly stated to the contrary. For example, a reference to “the actuator member”, “the locking element”, “the lumen”, or other features may be equally referred to all instances and quantities beyond one of said feature. As such, it will be understood that the following discussion may apply equally to any and/or all of the components for which there are more than one within the medical implant 14 (e.g., the at least one actuator member 50, the plurality of locking elements, etc.) and/or the medical implant system 10, unless explicitly stated to the contrary. Additionally, not all instances of some elements or features may be shown in each figure for clarity.
In some embodiments, the tubular anchor member 40 may include and/or form a plurality of anchor member intersection points 42 distributed around a circumference of the tubular anchor member 40. In some embodiments, the plurality of anchor member intersection points 42 may include two or more overlapping segments (e.g., a first segment, a second segment, a third segment, etc.) of the tubular anchor member 40 and/or the braid, filaments, wires, etc. thereof. In some embodiments, the two or more overlapping segments may be arranged in an alternating over-and-under pattern or arrangement. For example, at a first anchor member intersection point 42, a first segment may be disposed radially outward of a second segment. At an adjacent second anchor member intersection point 42 including the first segment, the first segment may be disposed radially inward of an overlapping segment (e.g., a third segment). If the first segment (or any single segment) is followed around the circumference of the tubular anchor member 40, the over-under-over pattern would continue alternating about the entire circumference of the tubular anchor member 40.
In some embodiments, the medical implant 14 may include a plurality of locking mechanisms attached to the tubular anchor member 40, the plurality of locking mechanisms being configured to secure the tubular anchor member 40 in the “deployed” and/or “released” configuration(s). In some embodiments, the medical implant 14 and/or the tubular anchor member 40 may be reversed and/or longitudinally extended back toward the “delivery” configuration at any point up until the plurality of locking mechanisms actually “locks” the medical implant 14 and/or the tubular anchor member 40 in the “deployed” configuration. In some embodiments, the at least one actuator member 50 may be configured to engage with the plurality of locking mechanisms and actuate the tubular anchor member 40 and/or the medical implant 14 between the “delivery” configuration, the “deployed” configuration, and/or the “released” configuration. In some embodiments, one actuator member 50 may correspond to, engage with, and/or actuate one locking mechanism. In some embodiments, each actuator member 50 may extend through a guide 38 adjacent to and covering one of the plurality of fingers, as described herein, of the coupler assembly 32, and through a collar 36 coupling and/or locking the finger to one of the plurality of locking mechanisms. The guide 38 may be disposed over each of the fingers proximal of the collar 36 and may serve to keep the fingers of the coupler assembly 32 associated with the actuator members 50 extending adjacent to (and axially slidable relative to) the fingers of the coupler assembly 32. Other configurations are also contemplated. For example, in some embodiments, one actuator member 50 may correspond to, engage with, and/or actuate more than one locking mechanism.
For simplicity and clarity purposes, not all elements of the disclosed invention are necessarily shown in each figure. In some illustrative examples, only one of the fingers of the coupler assembly 32, only one of the plurality of actuator members 50, only one of the post members 76, only one of the buckle members 58, only one of the collars 36, etc. are shown and discussed (the whole medical implant 14 and/or the tubular anchor member 40 may not be shown to facilitate understanding of the locking mechanisms and/or other elements). However, it will be understood that the following discussion may apply equally to any and/or all of the components for which there are more than one within the medical implant 14 (e.g., each of the plurality of fingers 34, collars 36, guides 38, actuator members 50, buckle members 58, post members 76, etc.) and/or the medical implant system 10.
In some embodiments, the plurality of locking mechanisms may each comprise a buckle member 58 or other receiving element fixedly attached to the tubular anchor member 40 (e.g., along an inner surface of the tubular anchor member 40), and an axially movable post member 76, for example at the commissure portions of the valve leaflets 16 (a post member 76 may sometimes be referred to as a “commissure post”, which may serve to secure the plurality of valve leaflets 16, or a post member 76 may be connected and/or attached to a commissure post). In some embodiments, the buckle member 58 or other receiving element may be configured to slidably receive at least a portion of the post member 76 therein to engage with the buckle member 58 and thereafter lock the tubular anchor member 40 and/or the medical implant 14 in the “deployed” and/or the “released” configuration(s). In some embodiments, each of the plurality of valve leaflets 16 may be secured to the tubular anchor member 40 at one post member 76. In some embodiments, each of the plurality of valve leaflets 16 may be secured to two adjacent post members 76 at opposing sides of the valve leaflet 16. In at least some embodiments, a medical implant 14 may include a plurality of post members 76 and a corresponding plurality of buckle members 58 (e.g., one post member 76 for each/one buckle member 58). Other configurations and correspondences are also contemplated. Some suitable but non-limiting materials for the buckle member(s) 58 and/or the post member(s) 76, for example metallic materials or polymeric materials, may be described below.
Positioned proximate to (e.g., aligned with) the plurality of post members 76 may be a corresponding plurality of buckle members 58, which may be secured and/or fixedly attached to the tubular anchor member 40 (e.g., along the interior of the tubular anchor member 40) with sutures, adhesives, or other suitable mechanisms. In some embodiments, the post member 76 may be axially translatable relative to the buckle member 58 generally parallel to the central longitudinal axis of the tubular anchor member 40 when the post member 76 is at least partially disposed within and/or engaged with the buckle member 58.
In some embodiments, one buckle member 58 may be fixedly attached to the tubular anchor member 40 proximate to each of the three post members 76 and/or proximate the proximal end of the tubular anchor member 40. Accordingly, in some embodiments, the tubular anchor member 40 may have a total of three buckle members 58 and three post members 76 attached thereto. Similarly, one actuator member 50 may be associated with each post member 76 and buckle member 58, for a total of three actuator members 50 in the illustrated example(s). Other embodiments are contemplated where fewer or more buckle members 58, post members 76, and/or actuator members 50 may be utilized.
In some embodiments, the medical implant 14 and/or the tubular anchor member 40 may be attached, coupled, and/or connected to the delivery system 12 by a coupler assembly 32, as seen in
In some embodiments, the plurality of valve leaflets 16 may be secured to the tubular anchor member 40 at, proximate to, and/or using (at least in part) individual, corresponding post members 76. In some embodiments, the plurality of valve leaflets 16 may also be secured to the distal end of the tubular anchor member 40. In at least some embodiments, the distal end of the tubular anchor member 40 may be interchangeably described as the “inflow” end or the “upstream” end of the tubular anchor member 40 and/or the medical implant 14. In at least some embodiments, the proximal end of the tubular anchor member 40 may be interchangeably described as the “outflow” end or the “downstream” end of the tubular anchor member 40 and/or the medical implant 14.
As will be described in more detail below, the post member 76 may be secured, attached, coupled, and/or connected to the distal end and/or the inflow end of the tubular anchor member 40. Therefore, in some embodiments, when the post member 76 is pulled proximally to engage the buckle member 58, as will be described herein, the distal end and/or the inflow end of the tubular anchor member 40 is also pulled proximally relative to the buckle member 58, thereby transitioning from the “delivery” configuration and/or the “everted” configuration toward the “deployed” configuration. In some embodiments, the plurality of valve leaflets 16 may be coupled and/or secured (e.g., to the post member 76, to the tubular anchor member 40, and/or back to themselves) using at least one suture, thread, wire, filament, or other suitable element. In some embodiments, the plurality of valve leaflets 16 may be coupled and/or secured (e.g., to the post member 76, to the tubular anchor member 40, and/or back to themselves) using an adhesive, a bonding agent, or other suitable securing means. In some embodiments, the plurality of valve leaflets 16 may be coupled and/or secured (e.g., to the post member 76, to the tubular anchor member 40, and/or back to themselves) using a fabric strip, a textile, or other thin flexible material. In some embodiments, the plurality of valve leaflets 16 may not be directly attached to the tubular anchor member 40.
In some embodiments, a seal member 44 may be circumferentially disposed on and/or about a distal portion and/or an inflow portion of the tubular anchor member 40, as seen in
In some embodiments, the seal member 44 may include a plurality of layers of polymeric material. Some suitable polymeric materials may include, but are not necessarily limited to, polycarbonate, polyurethane, polyamide, polyether block amide, polyethylene, polyethylene terephthalate, polypropylene, polyvinylchloride, polytetrafluoroethylene, polysulfone, and copolymers, blends, mixtures or combinations thereof. Other configurations and/or other suitable materials are also contemplated.
In some embodiments, the modulus of elasticity may vary and/or be different from layer to layer. In other embodiments, the elongation to break may vary and/or be different from layer to layer. In some embodiments, the seal member 44 may also include a reinforcement, a reinforcing layer, and/or at least one reinforcing member added to the polymeric material prior to curing. The reinforcement, the reinforcing layer, and/or the at least one reinforcing member may comprise a woven or nonwoven fabric and may be positioned within or between the various layers. In some embodiments, the reinforcement, the reinforcing layer, and/or the at least one reinforcing member may be positioned on a radially innermost surface or radially outermost surface of the seal member 44. In some embodiments, the reinforcement, the reinforcing layer, and/or the at least one reinforcing member may be generally aligned. In some embodiments, the reinforcement, the reinforcing layer, and/or the at least one reinforcing member may be randomly oriented and/or disposed on the seal member 44.
In some embodiments, a distal end of the seal member 44 may include a reinforcing band fixedly attached to the seal member 44 at and/or proximate the distal end and/or the inflow end of the tubular anchor member 40. In some embodiments, the reinforcing band may be integrally formed with, incorporated into, adhered to, and/or at least partially embedded within the seal member 44. In some embodiments, the reinforcing band may be formed from a woven or nonwoven fabric strip, a textile, or other thin flexible material. The reinforcing band may provide tear resistance in the vicinity of sutures, filaments, or other attachment elements associated with components or aspects of the medical implant 14. In some embodiments, the seal member 44 and/or the reinforcing band may extend longitudinally beyond the distal end and/or the inflow end of the tubular anchor member 40.
In some embodiments, the plurality of valve leaflets 16 may each define a secured end and a free end opposite the secured end, wherein the free ends of the plurality of valve leaflets 16 come together to define an outflow end of a valve disposed within the tubular anchor member 40 in the “deployed” configuration. In some embodiments, the secured end of each of the plurality of valve leaflets 16 may be directly attached to the seal member 44 and/or the reinforcing band at and/or proximate the distal end and/or the inflow end of the tubular anchor member 40. In some embodiments, the plurality of valve leaflets 16 may not be attached directly to the distal end and/or the inflow end of the tubular anchor member 40. In some embodiments, the plurality of valve leaflets 16 may be configured to shift between a deployed position wherein the outflow end of the valve is disposed within the tubular anchor member 40, and an everted position wherein the outflow end of the valve is disposed outside of, distal of, and/or upstream of the tubular anchor member 40.
As shown in
In some embodiments, the two axially-extending side walls may include a first side wall and a second side wall. In some embodiments, each side wall may include a proximal upper flange 57 and a distal upper flange 59 spaced longitudinally apart from the proximal upper flange 57, the proximal upper flange 57 and the distal upper flange 59 each extending from a top of the side wall distant from the back wall, the proximal upper flange 57 and the distal upper flange 59 each extending inwardly toward a central plane through the buckle member 58 (and/or the central longitudinal axis) normal to the back wall and/or the generally planar inner surface. In at least some embodiments, the proximal upper flange 57 and the distal upper flange 59 each may be oriented generally parallel to the back wall and/or the generally planar inner surface of the back wall. In some embodiments, the distal upper flange(s) 59 may define a proximal locking face configured to engage a latch portion extending laterally from the post member 76, as described herein.
In some embodiments, the back wall may extend between the two side walls, such that the two side walls, the back wall, and/or the proximal upper flange(s) 57 and the distal upper flange(s) 59 define a channel extending axially through the buckle member 58. In some embodiments, the buckle member 58 and/or the channel may include a suitable shape and/or keying feature(s) configured to cooperate with the actuator member 50 and/or the post member 76 to prevent relative rotation between the actuator member 50 and/or the post member 76 and the buckle member 58. In some embodiments, the back wall may include at least one aperture disposed within the back wall and between the two side walls. In some embodiments, a fastening element (e.g., a suture, thread, wire, filament, etc.) may pass through the at least one aperture and secure the buckle member 58 to the tubular anchor member 40. In some embodiments, the back wall may include a recessed portion in communication with some or all of the at least one aperture of the buckle member 58.
In some embodiments, the buckle member 58 may be substantially rigid. In some embodiments, the buckle member 58 may be formed from a metallic material, a polymeric material, a ceramic material, a composite material, or other suitable materials or combinations thereof. In some embodiments, the buckle member 58 may be partially rigid and/or partially flexible. In some embodiments, a buckle member 58 may permit an actuator member 50 and/or a post member 76 to be slidably received within and/or axially translate through the channel. In some embodiments, the buckle member 58 may be configured to prevent the actuator member 50 and/or the post member 76 from exiting the buckle member 58 in a radially inward direction toward the central longitudinal axis of the tubular anchor member 40, thereby limiting motion of the actuator member 50 and/or the post member 76 within the tubular anchor member 40 to axial translation.
As seen in
In some embodiments, the post member 76 may include a latch portion 80 connected to and/or integrally formed with or as a part of the central body portion. In some embodiments, the central body portion may be a laterally-arched central body portion extending laterally away from the first plane to form the latch portion 80. In some embodiments, the latch portion 80 may be resilient and/or self-biased away from the first plane. In some embodiments, the latch portion 80 may be configured to be deflected by the buckle member 58 and/or the distal upper flange(s) 59 as the post member 76 is translated proximally through the buckle member 58 and/or past the distal upper flange(s) 59.
In some embodiments, the post member 76 (in association and/or cooperation with axial translation of the actuator member 50) may be reversibly actuatable between a first orientation, wherein the proximal end extends distally from the central body portion (e.g., in the “delivery” and/or “everted” configuration), and a second orientation, wherein the proximal end extends proximally from the central body portion. In some embodiments, the post member 76 may be positioned and/or oriented in the second orientation in at least one configuration, including but not limited to, the “deployed” and/or “released” configurations. In some embodiments, the post member 76 may be axially translatable relative to the buckle member 58 and/or the tubular anchor member 40.
In some embodiments, the post member 76 may include a cantilevered leg 84 connected by a flexible hinge portion 82 at the distal end of the post member 76. In some embodiments, the cantilevered leg 84 may extend proximally from the hinge portion 82 and/or the distal end to a free end of the cantilevered leg 84 disposed radially inward from the central body portion and/or the latch portion 80 (relative to the tubular anchor member 40), when the post member 76 is in the second orientation. In some embodiments, the free end may be disposed proximal of the latch portion 80 when the post member 76 is in the second orientation. In some embodiments, the latch portion 80 may be disposed proximal of the distal end and/or the hinge portion 82 when the post member 76 is in the second orientation. In some embodiments, the cantilevered leg 84 may extend distally from the hinge portion 82 and/or the distal end to the free end of the cantilevered leg 84 disposed radially outward from the central body portion and/or the latch portion 80 (relative to the tubular anchor member 40), when the post member 76 is in the first orientation. In some embodiments, the free end may be disposed distal of the latch portion 80 when the post member 76 is in the first orientation. In some embodiments, the latch portion 80 may be disposed distal of the distal end and/or the hinge portion 82 when the post member 76 is in the first orientation.
In some embodiments, the hinge portion 82 may have and/or include a radius of curvature. For example, in some embodiments, the radius of curvature may be between 0 and 3 millimeters (mm). In some embodiments, the radius of curvature may be an inner radius of curvature of between 0 and 3 millimeters (mm). In some embodiments, the radius of curvature may be an outer radius of curvature of between 0 and 3 millimeters (mm). Other configurations and radii of curvature are also contemplated. In some embodiments, the hinge portion 82 may be configured to dispose the central body portion and the cantilevered leg 84 at an acute angle relative to each other. In some embodiments, the acute angle may be between about 0 degrees and about 90 degrees, between about 3 degrees and about 60 degrees, between about 5 degrees and about 45 degrees, between about 8 degrees and about 30 degrees, between about 10 degrees and about 20 degrees, between about 12 degrees and about 16 degrees, about 14 degrees, or another suitable angle. In at least some embodiments, the hinge portion 82 flexibly attaches the cantilevered leg 84 to the central body portion of the post member 76. In some embodiments, at least part of the cantilevered leg 84 may longitudinally overlap the buckle member 58 along a central longitudinal axis of the tubular anchor member 40 in the “deployed” configuration.
In some embodiments, the cantilevered leg 84 may include a free end and a secured end, where the cantilevered leg 84 may be attached to the central body portion and/or the distal end of the post member 76 at the secured end of the cantilevered leg 84, which may connect directly to the hinge portion 82. In some embodiments, the free end of the cantilevered leg 84 may be unattached (e.g., not directly attached) to any other structure of the medical implant 14, except for the cantilevered leg 84 and/or the plurality of valve leaflets 16. In other words, in some embodiments, the free end of the cantilevered leg 84 may not be directly attached to any other structure or feature of the medical implant 14 (e.g., the buckle member 58, the tubular anchor member 40, etc.). In some embodiments, the distal end of the post member 76, which in at least some embodiments may be proximate to and/or include the hinge portion 82, may be coupled to the distal end of the tubular anchor member 40, such as, for example, by a fastening element such as a suture, a filament, a wire, or other suitable means, as described herein. In some embodiments, the central body portion may include at least one aperture or hole 86 configured to receive a coupling element therethrough for securing the post member 76 to a distal end of the tubular anchor member 40, such as the suture, for example. As such, when the post member 76 is pulled proximally to engage the buckle member 58, the distal end of the tubular anchor member 40 is also pulled proximally relative to the buckle member 58, thereby transitioning from the “delivery” configuration toward the “deployed” configuration.
In some embodiments, the cantilevered leg(s) 84 may include a first longitudinally-oriented slot 85 extending therethrough between the secured end of the cantilevered leg 84 and the free end of the cantilevered leg 84. In at least some embodiments, at least one of the plurality of valve leaflets 16 may be coupled to and/or attached to the cantilevered leg(s) 84. In some embodiments, at least one of the plurality of valve leaflets 16 extend through the first longitudinally-oriented slot 85 of the cantilevered leg(s) 84. In some embodiments, attachment of the plurality of valve leaflets 16 to the cantilevered leg(s) 84 may provide flexibility and/or a reduction in stress between the plurality of valve leaflets 16 and the tubular anchor member 40. In some embodiments, at least a portion of the plurality of valve leaflets 16 may axially or longitudinally overlap at least a portion of the buckle members 58 at a common position along a central longitudinal axis of the tubular anchor member 40, which in some embodiments may allow for a shorter overall length or height of the medical implant 14. In some embodiments, the plurality of valve leaflets 16 may be secured directly to the cantilevered leg(s) 84. In some embodiments, the plurality of valve leaflets 16 may not be directly secured to the central body portion of the post member 76, but is instead coupled to the post member 76 via the cantilevered leg(s) 84. In some embodiments, the plurality of valve leaflets 16 may be wrapped around at least a portion of the cantilevered leg(s) 84. In some embodiments, a distalmost end of the plurality of valve leaflets 16 may be coupled to the distal end of the tubular anchor member 40. In some embodiments, the plurality of valve leaflets 16 may be coupled and/or secured (e.g., to the cantilevered leg 84, to the tubular anchor member 40, and/or back to themselves) using at least one suture, thread, wire, filament, or other suitable element. In some embodiments, the plurality of valve leaflets 16 may be coupled and/or secured (e.g., to the cantilevered leg 84, to the tubular anchor member 40, and/or back to themselves) using an adhesive, a bonding agent, or other suitable securing means. In some embodiments, the plurality of valve leaflets 16 may be coupled and/or secured (e.g., to the cantilevered leg 84, to the tubular anchor member 40, and/or back to themselves) using a fabric, a textile, or other thin flexible material.
In some embodiments, the post member 76 may include a receiving portion 88 proximate the proximal end. In some embodiments, the receiving portion 88 may include a first portion 81 and a second portion 83, each extending proximally from the central body portion and/or the latch portion 80 when the post member 76 is in the second orientation. In some embodiments, the first portion 81 and the second portion 83 may be spaced apart by a second longitudinally-oriented slot 87 disposed therebetween. In some embodiments, the second longitudinally-oriented slot 87 may narrow distally when the post member 76 is in the second orientation. In some embodiments, each of the first portion 81 and the second portion 83 may include an aperture 89 extending into and/or from the second longitudinally-oriented slot 87 such that the aperture 89 of each respective portion is in communication with the second longitudinally-oriented slot 87. In some embodiments, the aperture 89 of the first portion 81 and/or the aperture 89 of the second portion 83 may extend partially through its respective portion in a radial (with respect to the central longitudinal axis and/or the tubular anchor member 40) direction. In some embodiments, the aperture 89 of the first portion 81 and/or the aperture 89 of the second portion 83 may extend completely through its respective portion in a radial (with respect to the central longitudinal axis and/or the tubular anchor member 40) direction. In some embodiments, the first portion 81 and the second portion 83 may be configured to releasably engage the actuator member 50, thereby releasably connecting the actuator member 50 to the proximal end of the post member 76. In some embodiments, as the actuator member 50 and/or the post member 76 is translated proximally through the buckle member 58 in the second orientation, the second longitudinally-oriented slot 87 of the post member 76 may contact and/or engage a distal end of the finger of the coupler assembly 32. In some embodiments, the distal end of the finger may be configured to splay apart the first portion 81 and the second portion 83 by forcing the first portion 81 radially inward toward the central longitudinal axis relative to, and/or away from, the second portion 83 as the post member 76 is translated proximally when the first portion 81 contacts the finger, as seen in
In some embodiments, the latch portion 80 may be configured to engage the proximal locking face of the distal upper flange(s) 59 of the buckle member 58 when the post member 76 is in the second orientation, such that axial movement of the post member 76 distally relative to the buckle member 58 is prevented when the medical implant 14 and/or the tubular anchor member 40 is in the “deployed” configuration and/or the “released” configuration. In some embodiments, the latch portion 80 may include a transversely-oriented tooth extending laterally (or radially relative to the central longitudinal axis) therefrom and/or extends toward the cantilevered leg 84, wherein the tooth is configured to engage with the proximal locking face of the distal upper flange(s) 59 when the post member 76 is in the second orientation and/or the tubular anchor member 40 is in the “deployed” configuration and/or the “released” configuration. In some embodiments, the central body portion arches laterally (or radially relative to the central longitudinal axis) in a first direction relative to the proximal end and the distal end of the post member 76 (e.g., relative to the first plane), and the latch portion 80 and/or the tooth extends laterally (or radially relative to the central longitudinal axis) in the first direction from the central body portion.
In some embodiments, at least a portion of the post member 76 is flexible. In some embodiments, the latch portion 80 and/or the tooth may be movable relative to the central body portion. In some embodiments, the latch portion 80 may be deflectable relative to the central body portion such that the latch portion 80 and/or the tooth may translate laterally relative to the central body portion and/or radially outward relative to the central longitudinal axis. In some embodiments, the central body portion and/or the latch portion 80 may be configured to flex towards the first plane and/or a substantially straight configuration (e.g., radially relative to the central longitudinal axis) upon proximal translation of the post member 76 through the buckle member 58. In some embodiments, the free end of the cantilevered leg 84 may be movable toward and away from the central body portion (e.g., radially relative to the central longitudinal axis) by bending and/or pivoting the cantilevered leg 84 at and/or using the hinge portion 82.
In some embodiments, the central body portion may be unitary with and/or integrally formed with the latch portion 80, the hinge portion 82, the cantilevered leg 84, the receiving portion 88, and/or the first portion 81 and the second portion 83, of the post member 76 as and/or from a single piece of material. In some embodiments, the post member 76 may be formed from a single piece of wire, flat stock, or other suitable material as discussed herein. In some embodiments, the post member 76 may be formed by further processing the single piece of wire, flat stock, or other suitable material, such as by machining, stamping, laser cutting, or other suitable techniques.
In some embodiments, an example actuator member 50, as seen in
In some embodiments, the distal engagement portion 56 may include a lateral protrusion 60 proximate a distal end thereof. In some embodiments, the distal engagement portion 56 may include more than one lateral protrusion 60 proximate a distal end thereof. In some embodiments, the lateral protrusion 60 may be configured to matingly engage with the receiving portion 88, the aperture 89 of the first portion 81, and/or the aperture 89 of the second portion 83 of the post member 76. In some embodiments, the actuator member 50 may be prevented from rotating (e.g., is non-rotatable) relative to the post member 76 when the distal engagement portion 56 and/or the lateral protrusion 60 of the actuator member 50 is engaged with the receiving portion 88, the aperture 89 of the first portion 81, and/or the aperture 89 of the second portion 83 of the post member 76. In some embodiments, the actuator member 50 may be prevented from rotating (e.g., is non-rotatable) relative to the buckle member 58 when the distal engagement portion 56 and/or the lateral protrusion 60 of the actuator member 50 is engaged with the receiving portion 88, the aperture 89 of the first portion 81, and/or the aperture 89 of the second portion 83 of the post member 76, and/or when the post member 76 is engaged with the buckle member 58.
In use, the proximal end of the actuator member 50 may be connected to and/or manipulated or otherwise actuated by a user, for example using the handle 18, to shift the medical implant 14 from a “delivery” configuration and/or an “everted” configuration to a “deployed” configuration, and later to a “released” configuration. In some embodiments, the actuator member 50 may be axially translatable relative to the buckle member 58. In some embodiments, the actuator member 50 may extend through the channel of the buckle member 58 when the tubular anchor member 40 is in the “delivery” configuration and/or the “everted” configuration. In some embodiments, the actuator member 50 may extend distally of the tubular anchor member 40 in the “delivery” configuration and/or the “everted” configuration. In some embodiments, the actuator member 50 may be axially translatable within and/or through the channel of the buckle member 58 to engage the post member 76 with the buckle member 58.
In some embodiments, the actuator member 50 may be aligned with the post member 76 and/or the lateral protrusion(s) 60 may be releasably engaged with and/or connected to the proximal end of the post member 76 and/or the receiving portion 88, the aperture 89 of the first portion 81, and/or the aperture 89 of the second portion 83 of the post member 76. In some embodiments, the distal engagement portion 56 may be received within the second longitudinally-oriented slot 87 disposed between the first portion 81 and the second portion 83 of the post member 76. In some embodiments, the lateral protrusion(s) 60 may be configured to engage with, be received by, and/or extend into the aperture(s) 89 formed within each of the first portion 81 and the second portion 83 of the post member 76.
In some embodiments, the actuator member 50 and/or the proximal shaft portion 52 may be generally round, oblong, ovoid, rectangular, polygonal (e.g., two-sided, three-sided, four-sided, five-sided, six-sided, etc.) in shape. Other shapes, both regular and irregular, are also contemplated. For example, in some embodiments, the proximal shaft portion 52 may include a flattened portion or side oriented radially inward toward the central longitudinal axis. In some embodiments, the actuator member 50 may be formed from a single piece of wire, round stock, or other suitable material, as discussed herein. In some embodiments, the actuator member 50 may be formed by further processing the single piece of wire, round stock, or other suitable material, such as by machining, stamping, laser cutting, or other suitable techniques. Some suitable but non-limiting materials for the actuator member 50, the proximal shaft portion 52, the distal engagement portion 56, and/or the hinge element 54, for example metallic materials or polymeric materials, may be described below.
During delivery, after the medical implant 14 is advanced within the anatomy to the desired and/or target location, at least a portion of the delivery system 12 may be withdrawn (e.g., moved proximally relative to the medical implant 14) to expose the medical implant 14 in the “delivery” configuration and/or the “everted” configuration.
In some embodiments, a distal end of the axially movable post member 76 may be secured and/or attached (e.g., fixedly attached, movably attached, removably attached, etc.) to a distal portion of the tubular anchor member 40, such as by a suture 74, a tether, adhesives, or other suitable element. In some embodiments, the commissure post and/or the post member 76 may include at least one hole 86 (as seen in
In some embodiments, the post member 76 may be movable relative to the tubular anchor member 40 and/or the buckle member 58. In some embodiments, the post member 76 may be axially or longitudinally movable relative to the tubular anchor member 40 and/or the buckle member 58. In some embodiments, the buckle member 58 may be fixedly attached to the tubular anchor member 40 at and/or proximate the proximal end thereof. Other embodiments are contemplated where the buckle member 58 may be movably or removably attached to the tubular anchor member 40. In some embodiments, the post member 76 may be movably or removably attached to the tubular anchor member 40 and the buckle member 58 may be movably or removably attached to the tubular anchor member 40. In some embodiments, the post member 76 may be secured or attached (e.g., fixedly attached, movably attached, removably attached, etc.) to a distal end of the tubular anchor member 40.
As seen in
Turning now to
As seen in
Simultaneously with and/or immediately before splaying apart the receiving portion 88, and/or the first portion 81 and the second portion 83, of the post member 76 and/or disengagement of the distal engagement portion 56 and/or the lateral protrusion(s) 60 of the actuator member 50 from the aperture(s) 89 in the receiving portion 88, and/or the aperture 89 in the first portion 81 and the aperture 89 in the second portion 83, of the post member 76, a proximal face along a top or radially-inward facing side of the proximal shaft portion 52 of the actuator member 50 proximate to and/or proximal of the hinge element 54 may contact the collar 36, thereby proximally retracting the collar 36 along with the actuator member 50 to expose the finger 34 where it engages with the proximal end of the buckle member 58.
In some embodiments, after disengaging the distal engagement portion 56 and/or the lateral protrusion(s) 60 of the actuator member 50 from the aperture(s) 89 in the receiving portion 88, and/or the aperture 89 in the first portion 81 and the aperture 89 in the second portion 83, of the post member 76, the medical implant 14 and/or the tubular anchor member 40 may experience a minor or slight “spring-back” toward the “delivery” configuration. Additionally, since the collar 36 is no longer maintaining the finger 34 and the buckle member 58 in a coupled relationship or configuration, the finger(s) 34 and/or the coupler assembly 32 may separate from the medical implant 14, the buckle member(s) 58, and/or the tubular anchor member 40. As noted above, the latch portion 80 and/or the tooth may contact the proximally facing surface of the distal upper flange(s) 59, preventing the medical implant 14 and/or the tubular anchor member 40 from actuating further toward the “delivery” configuration. Upon separation and/or disengagement of the coupler assembly 32 from the medical implant 14, the medical implant 14 and/or the tubular anchor member 40 may be left in the “released” configuration, as seen in
The materials that can be used for the various components of the medical implant system 10 (and/or other systems disclosed herein) and the various elements thereof disclosed herein may include those commonly associated with medical devices. For simplicity purposes, the following discussion makes reference to the delivery system 12 and/or the medical implant 14. However, this is not intended to limit the devices and methods described herein, as the discussion may be applied to other elements, members, components, or devices disclosed herein, such as, but not limited to, the tubular anchor member 40, the actuator member 50, the locking mechanism, the post member 76, the buckle member 58, and/or elements or components thereof.
In some embodiments, the delivery system 12 and/or the medical implant 14, and/or components thereof (such as, but not limited to, the tubular anchor member 40, the locking mechanisms, the actuator members 50, etc.), may be made from a metal, metal alloy, polymer (some examples of which are disclosed below), a metal-polymer composite, ceramics, combinations thereof, and the like, or other suitable material. Some examples of suitable metals and metal alloys include stainless steel, such as 444V, 444L, and 314LV stainless steel; mild steel; nickel-titanium alloy such as linear-elastic and/or super-elastic nitinol; other nickel alloys such as nickel-chromium-molybdenum alloys (e.g., UNS: N06625 such as INCONEL® 625, UNS: N06022 such as HASTELLOY® C-22®, UNS: N10276 such as HASTELLOY® C276®, other HASTELLOY® alloys, and the like), nickel-copper alloys (e.g., UNS: N04400 such as MONEL® 400, NICKELVAC® 400, NICORROS® 400, and the like), nickel-cobalt-chromium-molybdenum alloys (e.g., UNS: R44035 such as MP35-N® and the like), nickel-molybdenum alloys (e.g., UNS: N10665 such as HASTELLOY® ALLOY B2®), other nickel-chromium alloys, other nickel-molybdenum alloys, other nickel-cobalt alloys, other nickel-iron alloys, other nickel-copper alloys, other nickel-tungsten or tungsten alloys, and the like; cobalt-chromium alloys; cobalt-chromium-molybdenum alloys (e.g., UNS: R44003 such as ELGILOY®, PHYNOX®, and the like); platinum enriched stainless steel; titanium; combinations thereof; and the like; or any other suitable material.
As alluded to herein, within the family of commercially available nickel-titanium or nitinol alloys, is a category designated “linear elastic” or “non-super-elastic” which, although may be similar in chemistry to conventional shape memory and super elastic varieties, may exhibit distinct and useful mechanical properties. Linear elastic and/or non-super-elastic nitinol may be distinguished from super elastic nitinol in that the linear elastic and/or non-super-elastic nitinol does not display a substantial “superelastic plateau” or “flag region” in its stress/strain curve like super elastic nitinol does. Instead, in the linear elastic and/or non-super-elastic nitinol, as recoverable strain increases, the stress continues to increase in a substantially linear, or a somewhat, but not necessarily entirely linear relationship until plastic deformation begins or at least in a relationship that is more linear than the super elastic plateau and/or flag region that may be seen with super elastic nitinol. Thus, for the purposes of this disclosure linear elastic and/or non-super-elastic nitinol may also be termed “substantially” linear elastic and/or non-super-elastic nitinol.
In some cases, linear elastic and/or non-super-elastic nitinol may also be distinguishable from super elastic nitinol in that linear elastic and/or non-super-elastic nitinol may accept up to about 2-5% strain while remaining substantially elastic (e.g., before plastically deforming) whereas super elastic nitinol may accept up to about 8% strain before plastically deforming. Both of these materials can be distinguished from other linear elastic materials such as stainless steel (that can also be distinguished based on its composition), which may accept only about 0.2 to 0.44 percent strain before plastically deforming.
In some embodiments, the linear elastic and/or non-super-elastic nickel-titanium alloy is an alloy that does not show any martensite/austenite phase changes that are detectable by differential scanning calorimetry (DSC) and dynamic metal thermal analysis (DMTA) analysis over a large temperature range. For example, in some embodiments, there may be no martensite/austenite phase changes detectable by DSC and DMTA analysis in the range of about −60 degrees Celsius (° C.) to about 120° C. in the linear elastic and/or non-super-elastic nickel-titanium alloy. The mechanical bending properties of such material may therefore be generally inert to the effect of temperature over this very broad range of temperature. In some embodiments, the mechanical bending properties of the linear elastic and/or non-super-elastic nickel-titanium alloy at ambient or room temperature are substantially the same as the mechanical properties at body temperature, for example, in that they do not display a super-elastic plateau and/or flag region. In other words, across a broad temperature range, the linear elastic and/or non-super-elastic nickel-titanium alloy maintains its linear elastic and/or non-super-elastic characteristics and/or properties.
In some embodiments, the linear elastic and/or non-super-elastic nickel-titanium alloy may be in the range of about 50 to about 60 weight percent nickel, with the remainder being essentially titanium. In some embodiments, the composition is in the range of about 54 to about 57 weight percent nickel. One example of a suitable nickel-titanium alloy is FHP-NT alloy commercially available from Furukawa Techno Material Co. of Kanagawa, Japan. Other suitable materials may include ULTANIUM™ (available from Neo-Metrics) and GUM METAL™ (available from Toyota). In some other embodiments, a superelastic alloy, for example a superelastic nitinol can be used to achieve desired properties.
In at least some embodiments, portions or all of the delivery system 12 and/or the medical implant 14, and/or components thereof, may also be doped with, made of, or otherwise include a radiopaque material. Radiopaque materials are understood to be materials capable of producing a relatively bright image on a fluoroscopy screen or another imaging technique during a medical procedure. This relatively bright image aids a user in determining the location of the delivery system 12 and/or the medical implant 14. Some examples of radiopaque materials can include, but are not limited to, gold, platinum, palladium, tantalum, tungsten alloy, polymer material loaded with a radiopaque filler, and the like. Additionally, other radiopaque marker bands and/or coils may also be incorporated into the design of the delivery system 12 and/or the medical implant 14 to achieve the same result.
In some embodiments, a degree of Magnetic Resonance Imaging (MRI) compatibility is imparted into the medical implant 14. For example, the delivery system 12 and/or the medical implant 14, and/or components or portions thereof, may be made of a material that does not substantially distort the image and create substantial artifacts (e.g., gaps in the image). Certain ferromagnetic materials, for example, may not be suitable because they may create artifacts in an MM image. The delivery system 12 and/or the medical implant 14, or portions thereof, may also be made from a material that the MRI machine can image. Some materials that exhibit these characteristics include, for example, tungsten, cobalt-chromium-molybdenum alloys (e.g., UNS: R44003 such as ELGILOY®, PHYNOX®, and the like), nickel-cobalt-chromium-molybdenum alloys (e.g., UNS: R44035 such as MP35-N® and the like), nitinol, and the like, and others.
In some embodiments, a sheath or covering (not shown) may be disposed over portions or all of the delivery system 12 and/or the medical implant 14. The sheath may be made from a polymer or other suitable material. Some examples of suitable polymers may include polytetrafluoroethylene (PTFE), ethylene tetrafluoroethylene (ETFE), fluorinated ethylene propylene (FEP), polyoxymethylene (POM, for example, DELRIN® available from DuPont), polyether block ester, polyurethane (for example, Polyurethane 85A), polypropylene (PP), polyvinylchloride (PVC), polyether-ester (for example, ARNITEL® available from DSM Engineering Plastics), ether or ester based copolymers (for example, butylene/poly(alkylene ether) phthalate and/or other polyester elastomers such as HYTREL® available from DuPont), polyamide (for example, DURETHAN® available from Bayer or CRISTAMID® available from Elf Atochem), elastomeric polyamides, block polyamide/ethers, polyether block amide (PEBA, for example available under the trade name PEBAX®), ethylene vinyl acetate copolymers (EVA), silicones, polyethylene (PE), Marlex high-density polyethylene, Marlex low-density polyethylene, linear low density polyethylene (for example REXELL®), polyester, polybutylene terephthalate (PBT), polyethylene terephthalate (PET), polytrimethylene terephthalate, polyethylene naphthalate (PEN), polyetheretherketone (PEEK), polyimide (PI), polyetherimide (PEI), polyphenylene sulfide (PPS), polyphenylene oxide (PPO), poly paraphenylene terephthalamide (for example, KEVLAR®), polysulfone, nylon, nylon-12 (such as GRILAMID® available from EMS American Grilon), perfluoro(propyl vinyl ether) (PFA), ethylene vinyl alcohol, polyolefin, polystyrene, epoxy, polyvinylidene chloride (PVdC), poly(styrene-b-isobutylene-b-styrene) (for example, SIBS and/or SIBS 50A), polycarbonates, ionomers, biocompatible polymers, other suitable materials, or mixtures, combinations, copolymers thereof, polymer/metal composites, and the like. In some embodiments the sheath can be blended with a liquid crystal polymer (LCP). For example, the mixture can contain up to about 6 percent LCP.
It should be understood that this disclosure is, in many respects, only illustrative. Changes may be made in details, particularly in matters of shape, size, and arrangement of steps without exceeding the scope of the invention. This may include, to the extent that it is appropriate, the use of any of the features of one example embodiment being used in other embodiments. The invention's scope is, of course, defined in the language in which the appended claims are expressed.
This application is a continuation of U.S. application Ser. No. 15/466,005, filed Mar. 22, 2017, which claims priority to U.S. Provisional Application Ser. No. 62/336,944, filed May 16, 2016.
| Number | Name | Date | Kind |
|---|---|---|---|
| 15192 | Peale | Jun 1856 | A |
| 2682057 | Lord | Jun 1954 | A |
| 2701559 | Cooper | Feb 1955 | A |
| 2832078 | Williams | Apr 1958 | A |
| 3029819 | Starks | Apr 1962 | A |
| 3099016 | Edwards | Jul 1963 | A |
| 3113586 | Edmark, Jr. | Dec 1963 | A |
| 3130418 | Head et al. | Apr 1964 | A |
| 3143742 | Cromie | Aug 1964 | A |
| 3221006 | Moore et al. | Nov 1965 | A |
| 3334629 | Cohn | May 1967 | A |
| 3365728 | Edwards et al. | Jan 1968 | A |
| 3367364 | Cruz, Jr. et al. | Feb 1968 | A |
| 3409013 | Berry | Nov 1968 | A |
| 3445916 | Schulte | May 1969 | A |
| 3540431 | Mobin-Uddin | Nov 1970 | A |
| 3548417 | Kischer et al. | Dec 1970 | A |
| 3570014 | Hancock | Mar 1971 | A |
| 3587115 | Shiley | Jun 1971 | A |
| 3592184 | Watkins et al. | Jul 1971 | A |
| 3628535 | Ostrowsky et al. | Dec 1971 | A |
| 3642004 | Osthagen et al. | Feb 1972 | A |
| 3657744 | Ersek | Apr 1972 | A |
| 3671979 | Moulopoulos | Jun 1972 | A |
| 3714671 | Edwards et al. | Feb 1973 | A |
| 3725961 | Magovern et al. | Apr 1973 | A |
| 3755823 | Hancock | Sep 1973 | A |
| 3795246 | Sturgeon | Mar 1974 | A |
| 3839741 | Haller | Oct 1974 | A |
| 3868956 | Alfidi et al. | Mar 1975 | A |
| 3874388 | King et al. | Apr 1975 | A |
| 3983581 | Angell et al. | Oct 1976 | A |
| 3997923 | Possis | Dec 1976 | A |
| 4035849 | Angell et al. | Jul 1977 | A |
| 4056854 | Boretos et al. | Nov 1977 | A |
| 4084268 | Ionescu et al. | Apr 1978 | A |
| 4106129 | Carpentier et al. | Aug 1978 | A |
| 4222126 | Boretos et al. | Sep 1980 | A |
| 4233690 | Akins | Nov 1980 | A |
| 4265694 | Boretos et al. | May 1981 | A |
| 4291420 | Reul | Sep 1981 | A |
| 4297749 | Davis et al. | Nov 1981 | A |
| 4323358 | Lentz et al. | Apr 1982 | A |
| 4326306 | Poler | Apr 1982 | A |
| 4339831 | Johnson | Jul 1982 | A |
| 4343048 | Ross et al. | Aug 1982 | A |
| 4345340 | Rosen | Aug 1982 | A |
| 4373216 | Klawitter | Feb 1983 | A |
| 4406022 | Roy | Sep 1983 | A |
| 4423809 | Mazzocco | Jan 1984 | A |
| 4425908 | Simon | Jan 1984 | A |
| 4470157 | Love | Sep 1984 | A |
| 4484579 | Meno et al. | Nov 1984 | A |
| 4501030 | Lane | Feb 1985 | A |
| 4531943 | Van Tassel et al. | Jul 1985 | A |
| 4535483 | Klawitter et al. | Aug 1985 | A |
| 4574803 | Storz | Mar 1986 | A |
| 4580568 | Gianturco | Apr 1986 | A |
| 4592340 | Boyles | Jun 1986 | A |
| 4602911 | Ahmadi et al. | Jul 1986 | A |
| 4605407 | Black et al. | Aug 1986 | A |
| 4610688 | Silvestrini et al. | Sep 1986 | A |
| 4612011 | Kautzky | Sep 1986 | A |
| 4617932 | Kornberg | Oct 1986 | A |
| 4643732 | Pietsch et al. | Feb 1987 | A |
| 4647283 | Carpentier et al. | Mar 1987 | A |
| 4648881 | Carpentier et al. | Mar 1987 | A |
| 4655218 | Kulik et al. | Apr 1987 | A |
| 4655771 | Wallsten | Apr 1987 | A |
| 4662885 | Dipisa, Jr. | May 1987 | A |
| 4665906 | Jervis | May 1987 | A |
| 4680031 | Alonso | Jul 1987 | A |
| 4692164 | Dzemeshkevich et al. | Sep 1987 | A |
| 4705516 | Barone et al. | Nov 1987 | A |
| 4710192 | Liotta et al. | Dec 1987 | A |
| 4733665 | Palmaz | Mar 1988 | A |
| 4755181 | Igoe | Jul 1988 | A |
| 4759758 | Gabbay | Jul 1988 | A |
| 4777951 | Cribier et al. | Oct 1988 | A |
| 4787899 | Lazarus | Nov 1988 | A |
| 4787901 | Baykut | Nov 1988 | A |
| 4796629 | Grayzel | Jan 1989 | A |
| 4819751 | Shimada et al. | Apr 1989 | A |
| 4829990 | Thuroff et al. | May 1989 | A |
| 4834755 | Silvestrini et al. | May 1989 | A |
| 4851001 | Taheri | Jul 1989 | A |
| 4856516 | Hillstead | Aug 1989 | A |
| 4865600 | Carpentier et al. | Sep 1989 | A |
| 4872874 | Taheri | Oct 1989 | A |
| 4873978 | Ginsburg | Oct 1989 | A |
| 4878495 | Grayzel | Nov 1989 | A |
| 4878906 | Lindemann et al. | Nov 1989 | A |
| 4883458 | Shiber | Nov 1989 | A |
| 4885005 | Nashef et al. | Dec 1989 | A |
| 4909252 | Goldberger | Mar 1990 | A |
| 4917102 | Miller et al. | Apr 1990 | A |
| 4922905 | Strecker | May 1990 | A |
| 4927426 | Dretler | May 1990 | A |
| 4954126 | Wallsten | Sep 1990 | A |
| 4966604 | Reiss | Oct 1990 | A |
| 4969890 | Sugita et al. | Nov 1990 | A |
| 4979939 | Shiber | Dec 1990 | A |
| 4986830 | Owens et al. | Jan 1991 | A |
| 4994077 | Dobben | Feb 1991 | A |
| 5002556 | Ishida et al. | Mar 1991 | A |
| 5002559 | Tower | Mar 1991 | A |
| 5007896 | Shiber | Apr 1991 | A |
| 5026366 | Leckrone | Jun 1991 | A |
| 5032128 | Alonso | Jul 1991 | A |
| 5037434 | Lane | Aug 1991 | A |
| 5047041 | Samuels | Sep 1991 | A |
| 5064435 | Porter | Nov 1991 | A |
| 5080668 | Bolz et al. | Jan 1992 | A |
| 5085635 | Cragg | Feb 1992 | A |
| 5089015 | Ross | Feb 1992 | A |
| 5122154 | Rhodes | Jun 1992 | A |
| 5132473 | Furutaka et al. | Jul 1992 | A |
| 5141494 | Danforth et al. | Aug 1992 | A |
| 5152771 | Sabbaghian et al. | Oct 1992 | A |
| 5159937 | Tremulis | Nov 1992 | A |
| 5161547 | Tower | Nov 1992 | A |
| 5163953 | Vince | Nov 1992 | A |
| 5167628 | Boyles | Dec 1992 | A |
| 5209741 | Spaeth | May 1993 | A |
| 5215541 | Nashef et al. | Jun 1993 | A |
| 5217481 | Barbara | Jun 1993 | A |
| 5217483 | Tower | Jun 1993 | A |
| 5238004 | Sahatjian et al. | Aug 1993 | A |
| 5258023 | Reger | Nov 1993 | A |
| 5258042 | Mehta | Nov 1993 | A |
| 5282847 | Trescony et al. | Feb 1994 | A |
| 5295958 | Shturman | Mar 1994 | A |
| 5332402 | Teitelbaum | Jul 1994 | A |
| 5336258 | Quintero et al. | Aug 1994 | A |
| 5350398 | Pavcnik et al. | Sep 1994 | A |
| 5360444 | Kusuhara | Nov 1994 | A |
| 5370685 | Stevens | Dec 1994 | A |
| 5389106 | Tower | Feb 1995 | A |
| 5397351 | Pavcnik et al. | Mar 1995 | A |
| 5409019 | Wilk | Apr 1995 | A |
| 5411552 | Andersen et al. | May 1995 | A |
| 5425739 | Jessen | Jun 1995 | A |
| 5425762 | Muller | Jun 1995 | A |
| 5431676 | Dubrul et al. | Jul 1995 | A |
| 5443446 | Shturman | Aug 1995 | A |
| 5443449 | Buelna | Aug 1995 | A |
| 5443477 | Marin et al. | Aug 1995 | A |
| 5443495 | Buscemi et al. | Aug 1995 | A |
| 5443499 | Schmitt | Aug 1995 | A |
| 5469868 | Reger | Nov 1995 | A |
| 5476506 | Lunn | Dec 1995 | A |
| 5476510 | Eberhardt et al. | Dec 1995 | A |
| 5480423 | Ravenscroft et al. | Jan 1996 | A |
| 5480424 | Cox | Jan 1996 | A |
| 5489297 | Duran | Feb 1996 | A |
| 5500014 | Quijano et al. | Mar 1996 | A |
| 5507767 | Maeda et al. | Apr 1996 | A |
| 5522881 | Lentz | Jun 1996 | A |
| 5534007 | St. Germain et al. | Jul 1996 | A |
| 5545133 | Burns et al. | Aug 1996 | A |
| 5545209 | Roberts et al. | Aug 1996 | A |
| 5545211 | An et al. | Aug 1996 | A |
| 5545214 | Stevens | Aug 1996 | A |
| 5549665 | Vesely et al. | Aug 1996 | A |
| 5554185 | Block et al. | Sep 1996 | A |
| 5571175 | Vanney et al. | Nov 1996 | A |
| 5571215 | Sterman et al. | Nov 1996 | A |
| 5573520 | Schwartz et al. | Nov 1996 | A |
| 5575818 | Pinchuk | Nov 1996 | A |
| 5591185 | Kilmer et al. | Jan 1997 | A |
| 5591195 | Taheri et al. | Jan 1997 | A |
| 5607464 | Trescony et al. | Mar 1997 | A |
| 5609626 | Quijano et al. | Mar 1997 | A |
| 5628784 | Strecker | May 1997 | A |
| 5645559 | Hachtman et al. | Jul 1997 | A |
| 5653745 | Trescony et al. | Aug 1997 | A |
| 5662671 | Barbut et al. | Sep 1997 | A |
| 5667523 | Bynon et al. | Sep 1997 | A |
| 5674277 | Freitag | Oct 1997 | A |
| 5681345 | Euteneuer | Oct 1997 | A |
| 5693083 | Baker et al. | Dec 1997 | A |
| 5693088 | Lazarus | Dec 1997 | A |
| 5693310 | Gries et al. | Dec 1997 | A |
| 5695498 | Tower | Dec 1997 | A |
| 5709713 | Evans et al. | Jan 1998 | A |
| 5713951 | Garrison et al. | Feb 1998 | A |
| 5713953 | Vallana et al. | Feb 1998 | A |
| 5716370 | Williamson, IV et al. | Feb 1998 | A |
| 5716417 | Girard et al. | Feb 1998 | A |
| 5720391 | Dohm et al. | Feb 1998 | A |
| 5725549 | Lam | Mar 1998 | A |
| 5728068 | Leone et al. | Mar 1998 | A |
| 5733325 | Robinson et al. | Mar 1998 | A |
| 5735842 | Krueger et al. | Apr 1998 | A |
| 5749890 | Shaknovich | May 1998 | A |
| 5755783 | Stobie et al. | May 1998 | A |
| 5756476 | Epstein et al. | May 1998 | A |
| 5769812 | Stevens et al. | Jun 1998 | A |
| 5769882 | Fogarty et al. | Jun 1998 | A |
| 5772609 | Nguyen et al. | Jun 1998 | A |
| 5776188 | Shepherd et al. | Jul 1998 | A |
| 5782904 | White et al. | Jul 1998 | A |
| 5800456 | Maeda et al. | Sep 1998 | A |
| 5800531 | Cosgrove et al. | Sep 1998 | A |
| 5807405 | Vanney et al. | Sep 1998 | A |
| 5817126 | Imran | Oct 1998 | A |
| 5824037 | Fogarty et al. | Oct 1998 | A |
| 5824041 | Lenker et al. | Oct 1998 | A |
| 5824043 | Cottone, Jr. | Oct 1998 | A |
| 5824053 | Khosravi et al. | Oct 1998 | A |
| 5824055 | Spiridigliozzi et al. | Oct 1998 | A |
| 5824056 | Rosenberg | Oct 1998 | A |
| 5824064 | Taheri | Oct 1998 | A |
| 5840081 | Andersen et al. | Nov 1998 | A |
| 5843158 | Lenker et al. | Dec 1998 | A |
| 5843161 | Solovay | Dec 1998 | A |
| 5855597 | Jayaraman | Jan 1999 | A |
| 5855601 | Bessler et al. | Jan 1999 | A |
| 5855602 | Angell | Jan 1999 | A |
| 5860966 | Tower | Jan 1999 | A |
| 5860996 | Urban et al. | Jan 1999 | A |
| 5861024 | Rashidi | Jan 1999 | A |
| 5861028 | Angell | Jan 1999 | A |
| 5868783 | Tower | Feb 1999 | A |
| 5876419 | Carpenter et al. | Mar 1999 | A |
| 5876448 | Thompson et al. | Mar 1999 | A |
| 5885228 | Rosenman et al. | Mar 1999 | A |
| 5888201 | Stinson et al. | Mar 1999 | A |
| 5891191 | Stinson | Apr 1999 | A |
| 5895399 | Barbut et al. | Apr 1999 | A |
| 5906619 | Olson et al. | May 1999 | A |
| 5907893 | Zadno-Azizi et al. | Jun 1999 | A |
| 5910154 | Tsugita et al. | Jun 1999 | A |
| 5911734 | Tsugita et al. | Jun 1999 | A |
| 5925063 | Khosravi | Jul 1999 | A |
| 5944738 | Amplatz et al. | Aug 1999 | A |
| 5954766 | Zadno-Azizi et al. | Sep 1999 | A |
| 5957949 | Leonhardt et al. | Sep 1999 | A |
| 5968070 | Bley et al. | Oct 1999 | A |
| 5984957 | Laptewicz, Jr. et al. | Nov 1999 | A |
| 5984959 | Robertson et al. | Nov 1999 | A |
| 5993469 | McKenzie et al. | Nov 1999 | A |
| 5997557 | Barbut et al. | Dec 1999 | A |
| 6010522 | Barbut et al. | Jan 2000 | A |
| 6015431 | Thornton et al. | Jan 2000 | A |
| 6022370 | Tower | Feb 2000 | A |
| 6027520 | Tsugita et al. | Feb 2000 | A |
| 6027525 | Suh et al. | Feb 2000 | A |
| 6042598 | Tsugita et al. | Mar 2000 | A |
| 6042607 | Williamson, IV et al. | Mar 2000 | A |
| 6051014 | Jang | Apr 2000 | A |
| 6059827 | Fenton, Jr. | May 2000 | A |
| 6074418 | Buchanan et al. | Jun 2000 | A |
| 6093203 | Uflacker | Jul 2000 | A |
| 6096074 | Pedros | Aug 2000 | A |
| 6110198 | Fogarty et al. | Aug 2000 | A |
| 6123723 | Konya et al. | Sep 2000 | A |
| 6132473 | Williams et al. | Oct 2000 | A |
| 6139510 | Palermo | Oct 2000 | A |
| 6142987 | Tsugita | Nov 2000 | A |
| 6146366 | Schachar | Nov 2000 | A |
| 6162245 | Jayaraman | Dec 2000 | A |
| 6165200 | Tsugita et al. | Dec 2000 | A |
| 6165209 | Patterson et al. | Dec 2000 | A |
| 6168579 | Tsugita | Jan 2001 | B1 |
| 6168614 | Andersen et al. | Jan 2001 | B1 |
| 6171327 | Daniel et al. | Jan 2001 | B1 |
| 6171335 | Wheatley et al. | Jan 2001 | B1 |
| 6179859 | Bates et al. | Jan 2001 | B1 |
| 6187016 | Hedges et al. | Feb 2001 | B1 |
| 6197053 | Cosgrove et al. | Mar 2001 | B1 |
| 6200336 | Pavcnik et al. | Mar 2001 | B1 |
| 6206911 | Milo | Mar 2001 | B1 |
| 6214036 | Letendre et al. | Apr 2001 | B1 |
| 6221006 | Dubrul et al. | Apr 2001 | B1 |
| 6221091 | Khosravi | Apr 2001 | B1 |
| 6221096 | Aiba et al. | Apr 2001 | B1 |
| 6221100 | Strecker | Apr 2001 | B1 |
| 6231544 | Tsuigita et al. | May 2001 | B1 |
| 6231551 | Barbut | May 2001 | B1 |
| 6241757 | An et al. | Jun 2001 | B1 |
| 6245102 | Jayaraman | Jun 2001 | B1 |
| 6251135 | Stinson et al. | Jun 2001 | B1 |
| 6258114 | Konya et al. | Jul 2001 | B1 |
| 6258115 | Dubrul | Jul 2001 | B1 |
| 6258120 | McKenzie et al. | Jul 2001 | B1 |
| 6258129 | Dybdal et al. | Jul 2001 | B1 |
| 6267783 | Letendre et al. | Jul 2001 | B1 |
| 6270513 | Tsugita et al. | Aug 2001 | B1 |
| 6277555 | Duran et al. | Aug 2001 | B1 |
| 6299637 | Shaolian et al. | Oct 2001 | B1 |
| 6302906 | Goicoechea et al. | Oct 2001 | B1 |
| 6306164 | Kujawski | Oct 2001 | B1 |
| 6309417 | Spence et al. | Oct 2001 | B1 |
| 6312465 | Griffin et al. | Nov 2001 | B1 |
| 6319281 | Patel | Nov 2001 | B1 |
| 6327772 | Zadno-Azizi et al. | Dec 2001 | B1 |
| 6336934 | Gilson et al. | Jan 2002 | B1 |
| 6336937 | Vonesh et al. | Jan 2002 | B1 |
| 6338735 | Stevens | Jan 2002 | B1 |
| 6346116 | Brooks et al. | Feb 2002 | B1 |
| 6348063 | Yassour et al. | Feb 2002 | B1 |
| 6352554 | De Paulis | Mar 2002 | B2 |
| 6352708 | Duran et al. | Mar 2002 | B1 |
| 6361545 | Macoviak et al. | Mar 2002 | B1 |
| 6363938 | Saadat et al. | Apr 2002 | B2 |
| 6364895 | Greenhalgh | Apr 2002 | B1 |
| 6371970 | Khosravi et al. | Apr 2002 | B1 |
| 6371983 | Lane | Apr 2002 | B1 |
| 6379383 | Palmaz et al. | Apr 2002 | B1 |
| 6387122 | Cragg | May 2002 | B1 |
| 6398807 | Chouinard et al. | Jun 2002 | B1 |
| 6402736 | Brown et al. | Jun 2002 | B1 |
| 6409750 | Hyodoh et al. | Jun 2002 | B1 |
| 6416510 | Altman et al. | Jul 2002 | B1 |
| 6425916 | Garrison et al. | Jul 2002 | B1 |
| 6440164 | DiMatteo et al. | Aug 2002 | B1 |
| 6454799 | Schreck | Sep 2002 | B1 |
| 6458153 | Bailey et al. | Oct 2002 | B1 |
| 6461382 | Cao | Oct 2002 | B1 |
| 6468303 | Amplatz et al. | Oct 2002 | B1 |
| 6468660 | Ogle et al. | Oct 2002 | B2 |
| 6475239 | Campbell et al. | Nov 2002 | B1 |
| 6482228 | Norred | Nov 2002 | B1 |
| 6485501 | Green | Nov 2002 | B1 |
| 6485502 | Don Michael et al. | Nov 2002 | B2 |
| 6488704 | Connelly et al. | Dec 2002 | B1 |
| 6494909 | Greenhalgh | Dec 2002 | B2 |
| 6503272 | Duerig et al. | Jan 2003 | B2 |
| 6508803 | Horikawa et al. | Jan 2003 | B1 |
| 6508833 | Pavcnik et al. | Jan 2003 | B2 |
| 6527800 | McGuckin, Jr. et al. | Mar 2003 | B1 |
| 6530949 | Konya et al. | Mar 2003 | B2 |
| 6530952 | Vesely | Mar 2003 | B2 |
| 6537297 | Tsugita et al. | Mar 2003 | B2 |
| 6540768 | Diaz et al. | Apr 2003 | B1 |
| 6540782 | Snyders | Apr 2003 | B1 |
| 6562058 | Seguin et al. | May 2003 | B2 |
| 6569196 | Vesely | May 2003 | B1 |
| 6572643 | Gharibadeh | Jun 2003 | B1 |
| 6585766 | Huynh et al. | Jul 2003 | B1 |
| 6592546 | Barbut et al. | Jul 2003 | B1 |
| 6592614 | Lenker et al. | Jul 2003 | B2 |
| 6605112 | Moll et al. | Aug 2003 | B1 |
| 6610077 | Hancock et al. | Aug 2003 | B1 |
| 6616682 | Joergensen et al. | Sep 2003 | B2 |
| 6622604 | Chouinard et al. | Sep 2003 | B1 |
| 6623518 | Thompson et al. | Sep 2003 | B2 |
| 6623521 | Steinke et al. | Sep 2003 | B2 |
| 6626938 | Butaric et al. | Sep 2003 | B1 |
| 6632243 | Zadno-Azizi et al. | Oct 2003 | B1 |
| 6635068 | Dubrul et al. | Oct 2003 | B1 |
| 6635079 | Unsworth et al. | Oct 2003 | B2 |
| 6635080 | Lauterjung et al. | Oct 2003 | B1 |
| 6652571 | White et al. | Nov 2003 | B1 |
| 6652578 | Bailey et al. | Nov 2003 | B2 |
| 6663588 | DuBois et al. | Dec 2003 | B2 |
| 6663663 | Kim et al. | Dec 2003 | B2 |
| 6663667 | Dehdashtian et al. | Dec 2003 | B2 |
| 6669724 | Park et al. | Dec 2003 | B2 |
| 6673089 | Yassour et al. | Jan 2004 | B1 |
| 6673109 | Cox | Jan 2004 | B2 |
| 6676668 | Mercereau et al. | Jan 2004 | B2 |
| 6676692 | Rabkin et al. | Jan 2004 | B2 |
| 6676698 | McGuckin, Jr. et al. | Jan 2004 | B2 |
| 6682543 | Barbut et al. | Jan 2004 | B2 |
| 6682558 | Tu et al. | Jan 2004 | B2 |
| 6682559 | Myers et al. | Jan 2004 | B2 |
| 6685739 | DiMatteo et al. | Feb 2004 | B2 |
| 6689144 | Gerberding | Feb 2004 | B2 |
| 6689164 | Seguin | Feb 2004 | B1 |
| 6692512 | Jang | Feb 2004 | B2 |
| 6695864 | Macoviak et al. | Feb 2004 | B2 |
| 6695865 | Boyle et al. | Feb 2004 | B2 |
| 6702851 | Chinn et al. | Mar 2004 | B1 |
| 6712842 | Gifford, III et al. | Mar 2004 | B1 |
| 6712843 | Elliott | Mar 2004 | B2 |
| 6714842 | Ito | Mar 2004 | B1 |
| 6719789 | Cox | Apr 2004 | B2 |
| 6723116 | Taheri | Apr 2004 | B2 |
| 6729356 | Baker et al. | May 2004 | B1 |
| 6730118 | Spenser | May 2004 | B2 |
| 6730377 | Wang | May 2004 | B2 |
| 6733525 | Yang et al. | May 2004 | B2 |
| 6736846 | Cox | May 2004 | B2 |
| 6752828 | Thornton | Jun 2004 | B2 |
| 6755854 | Gillick et al. | Jun 2004 | B2 |
| 6758855 | Fulton, III et al. | Jul 2004 | B2 |
| 6764503 | Ishimaru | Jul 2004 | B1 |
| 6764509 | Chinn et al. | Jul 2004 | B2 |
| 6767345 | St. Germain et al. | Jul 2004 | B2 |
| 6769434 | Liddicoat et al. | Aug 2004 | B2 |
| 6773454 | Wholey et al. | Aug 2004 | B2 |
| 6773456 | Gordon et al. | Aug 2004 | B1 |
| 6776791 | Stallings et al. | Aug 2004 | B1 |
| 6786925 | Schoon et al. | Sep 2004 | B1 |
| 6790229 | Berreklouw | Sep 2004 | B1 |
| 6790230 | Beyersdorf et al. | Sep 2004 | B2 |
| 6790237 | Stinson | Sep 2004 | B2 |
| 6792979 | Konya et al. | Sep 2004 | B2 |
| 6797002 | Spence et al. | Sep 2004 | B2 |
| 6814746 | Thompson et al. | Nov 2004 | B2 |
| 6814754 | Greenhalgh | Nov 2004 | B2 |
| 6821297 | Snyders | Nov 2004 | B2 |
| 6824041 | Grieder et al. | Nov 2004 | B2 |
| 6830585 | Artof et al. | Dec 2004 | B1 |
| 6837901 | Rabkin et al. | Jan 2005 | B2 |
| 6840957 | DiMatteo et al. | Jan 2005 | B2 |
| 6843802 | Villalobos et al. | Jan 2005 | B1 |
| 6849085 | Marton | Feb 2005 | B2 |
| 6863668 | Gillespie et al. | Mar 2005 | B2 |
| 6863688 | Ralph et al. | Mar 2005 | B2 |
| 6866650 | Stevens et al. | Mar 2005 | B2 |
| 6866669 | Buzzard et al. | Mar 2005 | B2 |
| 6872223 | Roberts et al. | Mar 2005 | B2 |
| 6872226 | Cali et al. | Mar 2005 | B2 |
| 6875231 | Anduiza et al. | Apr 2005 | B2 |
| 6881220 | Edwin et al. | Apr 2005 | B2 |
| 6887266 | Williams et al. | May 2005 | B2 |
| 6890340 | Duane | May 2005 | B2 |
| 6893459 | Macoviak | May 2005 | B1 |
| 6893460 | Spenser et al. | May 2005 | B2 |
| 6896690 | Lambrecht et al. | May 2005 | B1 |
| 6905743 | Chen et al. | Jun 2005 | B1 |
| 6908481 | Cribier | Jun 2005 | B2 |
| 6911036 | Douk et al. | Jun 2005 | B2 |
| 6911040 | Johnson et al. | Jun 2005 | B2 |
| 6911043 | Myers et al. | Jun 2005 | B2 |
| 6936058 | Forde et al. | Aug 2005 | B2 |
| 6936067 | Buchanan | Aug 2005 | B2 |
| 6939352 | Buzzard et al. | Sep 2005 | B2 |
| 6951571 | Srivastava | Oct 2005 | B1 |
| 6953332 | Kurk et al. | Oct 2005 | B1 |
| 6964673 | Tsugita et al. | Nov 2005 | B2 |
| 6969395 | Eskuri | Nov 2005 | B2 |
| 6972025 | WasDyke | Dec 2005 | B2 |
| 6974464 | Quijano et al. | Dec 2005 | B2 |
| 6974474 | Pavcnik et al. | Dec 2005 | B2 |
| 6974476 | McGuckin, Jr. et al. | Dec 2005 | B2 |
| 6979350 | Moll et al. | Dec 2005 | B2 |
| 6984242 | Campbell et al. | Jan 2006 | B2 |
| 6989027 | Allen et al. | Jan 2006 | B2 |
| 7004176 | Lau | Feb 2006 | B2 |
| 7011681 | Vesely | Mar 2006 | B2 |
| 7018406 | Seguin et al. | Mar 2006 | B2 |
| 7025791 | Levine et al. | Apr 2006 | B2 |
| 7037331 | Mitelberg et al. | May 2006 | B2 |
| 7041132 | Quijano et al. | May 2006 | B2 |
| 7044966 | Svanidze et al. | May 2006 | B2 |
| 7097658 | Oktay | Aug 2006 | B2 |
| 7108715 | Lawrence-Brown et al. | Sep 2006 | B2 |
| 7122020 | Mogul | Oct 2006 | B2 |
| 7125418 | Duran et al. | Oct 2006 | B2 |
| 7141063 | White et al. | Nov 2006 | B2 |
| 7147663 | Berg et al. | Dec 2006 | B1 |
| 7166097 | Barbut | Jan 2007 | B2 |
| 7175652 | Cook et al. | Feb 2007 | B2 |
| 7175653 | Gaber | Feb 2007 | B2 |
| 7175654 | Bonsignore et al. | Feb 2007 | B2 |
| 7175656 | Khairkhahan | Feb 2007 | B2 |
| 7189258 | Johnson et al. | Mar 2007 | B2 |
| 7191018 | Gielen et al. | Mar 2007 | B2 |
| 7201772 | Schwammenthal et al. | Apr 2007 | B2 |
| 7235093 | Gregorich | Jun 2007 | B2 |
| 7252682 | Seguin | Aug 2007 | B2 |
| 7258696 | Rabkin et al. | Aug 2007 | B2 |
| 7261732 | Justino | Aug 2007 | B2 |
| 7264632 | Wright et al. | Sep 2007 | B2 |
| 7267686 | DiMatteo et al. | Sep 2007 | B2 |
| 7276078 | Spenser et al. | Oct 2007 | B2 |
| 7322932 | Xie et al. | Jan 2008 | B2 |
| 7326236 | Andreas et al. | Feb 2008 | B2 |
| 7329279 | Haug et al. | Feb 2008 | B2 |
| 7331993 | White | Feb 2008 | B2 |
| 7374560 | Ressemann et al. | May 2008 | B2 |
| 7381219 | Salahieh et al. | Jun 2008 | B2 |
| 7381220 | Macoviak et al. | Jun 2008 | B2 |
| 7399315 | Iobbi | Jul 2008 | B2 |
| 7445631 | Salahieh et al. | Nov 2008 | B2 |
| 7470285 | Nugent et al. | Dec 2008 | B2 |
| 7473417 | Zeltinger et al. | Jan 2009 | B2 |
| 7491232 | Bolduc et al. | Feb 2009 | B2 |
| 7510574 | Lê et al. | Mar 2009 | B2 |
| 7524330 | Berreklouw | Apr 2009 | B2 |
| 7530995 | Quijano et al. | May 2009 | B2 |
| 7544206 | Cohn | Jun 2009 | B2 |
| 7601159 | Ewers et al. | Oct 2009 | B2 |
| 7622276 | Cunanan et al. | Nov 2009 | B2 |
| 7628802 | White et al. | Dec 2009 | B2 |
| 7628803 | Pavcnik et al. | Dec 2009 | B2 |
| 7632298 | Hijikema et al. | Dec 2009 | B2 |
| 7641687 | Chinn et al. | Jan 2010 | B2 |
| 7674282 | Wu et al. | Mar 2010 | B2 |
| 7712606 | Salahieh et al. | May 2010 | B2 |
| 7722638 | Deyette, Jr. et al. | May 2010 | B2 |
| 7722662 | Steinke et al. | May 2010 | B2 |
| 7722666 | Lafontaine | May 2010 | B2 |
| 7731742 | Schlick et al. | Jun 2010 | B2 |
| 7736388 | Goldfarb et al. | Jun 2010 | B2 |
| 7748389 | Salahieh et al. | Jul 2010 | B2 |
| 7758625 | Wu et al. | Jul 2010 | B2 |
| 7763065 | Schmid et al. | Jul 2010 | B2 |
| 7780725 | Haug | Aug 2010 | B2 |
| 7799065 | Pappas | Sep 2010 | B2 |
| 7803185 | Gabbay | Sep 2010 | B2 |
| 7824442 | Salahieh et al. | Nov 2010 | B2 |
| 7824443 | Salahieh et al. | Nov 2010 | B2 |
| 7833262 | McGuckin, Jr. et al. | Nov 2010 | B2 |
| 7846204 | Letac et al. | Dec 2010 | B2 |
| 7857845 | Stacchino et al. | Dec 2010 | B2 |
| 7892292 | Stack et al. | Feb 2011 | B2 |
| 7914574 | Schmid et al. | Mar 2011 | B2 |
| 7918880 | Austin | Apr 2011 | B2 |
| 7927363 | Perouse | Apr 2011 | B2 |
| 7938851 | Olson et al. | May 2011 | B2 |
| 7947071 | Schmid et al. | May 2011 | B2 |
| 7959666 | Salahieh | Jun 2011 | B2 |
| 7959672 | Salahieh et al. | Jun 2011 | B2 |
| 7967853 | Eidenschink et al. | Jun 2011 | B2 |
| 7988724 | Salahieh et al. | Aug 2011 | B2 |
| 8048153 | Salahieh et al. | Nov 2011 | B2 |
| 8052749 | Salahieh et al. | Nov 2011 | B2 |
| 8136659 | Salahieh et al. | Mar 2012 | B2 |
| 8157853 | Laske et al. | Apr 2012 | B2 |
| 8167894 | Miles et al. | May 2012 | B2 |
| 8172896 | McNamara et al. | May 2012 | B2 |
| 8182528 | Salahieh et al. | May 2012 | B2 |
| 8192351 | Fishler et al. | Jun 2012 | B2 |
| 8226710 | Nguyen et al. | Jul 2012 | B2 |
| 8231670 | Salahieh et al. | Jul 2012 | B2 |
| 8236049 | Rowe et al. | Aug 2012 | B2 |
| 8246678 | Salahieh et al. | Aug 2012 | B2 |
| 8252051 | Chau et al. | Aug 2012 | B2 |
| 8252052 | Salahieh et al. | Aug 2012 | B2 |
| 8277500 | Schmid et al. | Oct 2012 | B2 |
| 8287584 | Salahieh et al. | Oct 2012 | B2 |
| 8308798 | Pintor et al. | Nov 2012 | B2 |
| 8317858 | Straubinger et al. | Nov 2012 | B2 |
| 8323335 | Rowe et al. | Dec 2012 | B2 |
| 8328868 | Paul | Dec 2012 | B2 |
| 8343213 | Salahieh et al. | Jan 2013 | B2 |
| 8348999 | Kheradvar et al. | Jan 2013 | B2 |
| 8366767 | Zhang | Feb 2013 | B2 |
| 8376865 | Forster et al. | Feb 2013 | B2 |
| 8377117 | Keidar et al. | Feb 2013 | B2 |
| 8398708 | Meiri | Mar 2013 | B2 |
| 8403983 | Quadri et al. | Mar 2013 | B2 |
| 8414644 | Quadri et al. | Apr 2013 | B2 |
| 8414645 | Dwork et al. | Apr 2013 | B2 |
| 8512394 | Schmid et al. | Aug 2013 | B2 |
| 8523936 | Schmid et al. | Sep 2013 | B2 |
| 8540762 | Schmid et al. | Sep 2013 | B2 |
| 8545547 | Schmid et al. | Oct 2013 | B2 |
| 8579962 | Salahieh et al. | Nov 2013 | B2 |
| 8603160 | Salahieh et al. | Dec 2013 | B2 |
| 8617235 | Schmid et al. | Dec 2013 | B2 |
| 8617236 | Paul et al. | Dec 2013 | B2 |
| 8623074 | Ryan | Jan 2014 | B2 |
| 8623076 | Salahieh et al. | Jan 2014 | B2 |
| 8623078 | Salahieh et al. | Jan 2014 | B2 |
| 8668733 | Haug et al. | Mar 2014 | B2 |
| 8696743 | Holecek et al. | Apr 2014 | B2 |
| 8795354 | Benichou et al. | Aug 2014 | B2 |
| 8828078 | Salahieh et al. | Sep 2014 | B2 |
| 8840662 | Salahieh et al. | Sep 2014 | B2 |
| 8840663 | Salahieh et al. | Sep 2014 | B2 |
| 8858620 | Salahieh et al. | Oct 2014 | B2 |
| 8894703 | Salahieh et al. | Nov 2014 | B2 |
| 8951299 | Paul et al. | Feb 2015 | B2 |
| 8992608 | Haug et al. | Mar 2015 | B2 |
| 9005273 | Salahieh et al. | Apr 2015 | B2 |
| 9011521 | Haug et al. | Apr 2015 | B2 |
| 9168131 | Yohanan et al. | Oct 2015 | B2 |
| 9283072 | Bruchman et al. | Mar 2016 | B2 |
| 9393114 | Sutton et al. | Jul 2016 | B2 |
| 9901445 | Backus et al. | Feb 2018 | B2 |
| 10201416 | Backus | Feb 2019 | B2 |
| 20010002445 | Vesely | May 2001 | A1 |
| 20010007956 | Letac et al. | Jul 2001 | A1 |
| 20010010017 | Letac et al. | Jul 2001 | A1 |
| 20010021872 | Bailey et al. | Sep 2001 | A1 |
| 20010025196 | Chinn et al. | Sep 2001 | A1 |
| 20010027338 | Greenberg | Oct 2001 | A1 |
| 20010032013 | Marton | Oct 2001 | A1 |
| 20010039450 | Pavcnik et al. | Nov 2001 | A1 |
| 20010041928 | Pavcnik et al. | Nov 2001 | A1 |
| 20010041930 | Globerman et al. | Nov 2001 | A1 |
| 20010044634 | Don Michael et al. | Nov 2001 | A1 |
| 20010044652 | Moore | Nov 2001 | A1 |
| 20010044656 | Williamson, IV et al. | Nov 2001 | A1 |
| 20020002396 | Fulkerson | Jan 2002 | A1 |
| 20020010489 | Grayzel et al. | Jan 2002 | A1 |
| 20020026233 | Shaknovich | Feb 2002 | A1 |
| 20020029014 | Jayaraman | Mar 2002 | A1 |
| 20020029981 | Nigam | Mar 2002 | A1 |
| 20020032480 | Spence et al. | Mar 2002 | A1 |
| 20020032481 | Gabbay | Mar 2002 | A1 |
| 20020042651 | Liddicoat et al. | Apr 2002 | A1 |
| 20020052651 | Myers et al. | May 2002 | A1 |
| 20020055767 | Forde et al. | May 2002 | A1 |
| 20020055769 | Wang | May 2002 | A1 |
| 20020055774 | Liddicoat | May 2002 | A1 |
| 20020058987 | Butaric et al. | May 2002 | A1 |
| 20020058995 | Stevens | May 2002 | A1 |
| 20020077696 | Zadno-Azizi et al. | Jun 2002 | A1 |
| 20020082609 | Green | Jun 2002 | A1 |
| 20020095173 | Mazzocchi et al. | Jul 2002 | A1 |
| 20020095209 | Zadno-Azizi et al. | Jul 2002 | A1 |
| 20020111674 | Chouinard et al. | Aug 2002 | A1 |
| 20020120328 | Pathak et al. | Aug 2002 | A1 |
| 20020123802 | Snyders | Sep 2002 | A1 |
| 20020138138 | Yang | Sep 2002 | A1 |
| 20020151970 | Garrison et al. | Oct 2002 | A1 |
| 20020156522 | Ivancev et al. | Oct 2002 | A1 |
| 20020161390 | Mouw | Oct 2002 | A1 |
| 20020161392 | Dubrul | Oct 2002 | A1 |
| 20020161394 | Macoviak et al. | Oct 2002 | A1 |
| 20020165576 | Boyle et al. | Nov 2002 | A1 |
| 20020177766 | Mogul | Nov 2002 | A1 |
| 20020183781 | Casey et al. | Dec 2002 | A1 |
| 20020188341 | Elliott | Dec 2002 | A1 |
| 20020188344 | Bolea et al. | Dec 2002 | A1 |
| 20020193871 | Beyersdorf et al. | Dec 2002 | A1 |
| 20030014104 | Cribier | Jan 2003 | A1 |
| 20030023303 | Palmaz et al. | Jan 2003 | A1 |
| 20030028247 | Cali | Feb 2003 | A1 |
| 20030036791 | Philipp et al. | Feb 2003 | A1 |
| 20030040736 | Stevens et al. | Feb 2003 | A1 |
| 20030040771 | Hyodoh et al. | Feb 2003 | A1 |
| 20030040772 | Hyodoh et al. | Feb 2003 | A1 |
| 20030040791 | Oktay | Feb 2003 | A1 |
| 20030040792 | Gabbay | Feb 2003 | A1 |
| 20030050694 | Yang et al. | Mar 2003 | A1 |
| 20030055495 | Pease et al. | Mar 2003 | A1 |
| 20030057156 | Peterson et al. | Mar 2003 | A1 |
| 20030060844 | Borillo et al. | Mar 2003 | A1 |
| 20030069492 | Abrams et al. | Apr 2003 | A1 |
| 20030069646 | Stinson | Apr 2003 | A1 |
| 20030070944 | Nigam | Apr 2003 | A1 |
| 20030074058 | Sherry | Apr 2003 | A1 |
| 20030093145 | Lawrence-Brown et al. | May 2003 | A1 |
| 20030100918 | Duane | May 2003 | A1 |
| 20030100919 | Hopkins et al. | May 2003 | A1 |
| 20030109924 | Cribier | Jun 2003 | A1 |
| 20030109930 | Bluni et al. | Jun 2003 | A1 |
| 20030114912 | Sequin et al. | Jun 2003 | A1 |
| 20030114913 | Spenser | Jun 2003 | A1 |
| 20030125795 | Pavcnik et al. | Jul 2003 | A1 |
| 20030130729 | Paniagua et al. | Jul 2003 | A1 |
| 20030135257 | Taheri | Jul 2003 | A1 |
| 20030144732 | Cosgrove et al. | Jul 2003 | A1 |
| 20030149475 | Hyodoh et al. | Aug 2003 | A1 |
| 20030149476 | Damm et al. | Aug 2003 | A1 |
| 20030149478 | Figulla et al. | Aug 2003 | A1 |
| 20030153974 | Spenser et al. | Aug 2003 | A1 |
| 20030165352 | Ibrahim et al. | Sep 2003 | A1 |
| 20030171803 | Shimon | Sep 2003 | A1 |
| 20030176884 | Berrada et al. | Sep 2003 | A1 |
| 20030181850 | Diamond et al. | Sep 2003 | A1 |
| 20030187495 | Cully et al. | Oct 2003 | A1 |
| 20030191516 | Weldon et al. | Oct 2003 | A1 |
| 20030195609 | Berenstein et al. | Oct 2003 | A1 |
| 20030199759 | Richard | Oct 2003 | A1 |
| 20030199913 | Dubrul et al. | Oct 2003 | A1 |
| 20030199971 | Tower et al. | Oct 2003 | A1 |
| 20030199972 | Zadno-Azizi et al. | Oct 2003 | A1 |
| 20030204249 | Letort | Oct 2003 | A1 |
| 20030208224 | Broome | Nov 2003 | A1 |
| 20030212429 | Keegan et al. | Nov 2003 | A1 |
| 20030212452 | Zadno-Azizi et al. | Nov 2003 | A1 |
| 20030212454 | Scott et al. | Nov 2003 | A1 |
| 20030216774 | Larson | Nov 2003 | A1 |
| 20030225445 | Derus et al. | Dec 2003 | A1 |
| 20030229390 | Ashton et al. | Dec 2003 | A1 |
| 20030233117 | Adams et al. | Dec 2003 | A1 |
| 20030236567 | Elliot | Dec 2003 | A1 |
| 20040019374 | Hojeibane et al. | Jan 2004 | A1 |
| 20040033364 | Spiridigliozzi et al. | Feb 2004 | A1 |
| 20040034411 | Quijano | Feb 2004 | A1 |
| 20040039436 | Spenser et al. | Feb 2004 | A1 |
| 20040049224 | Buehlmann et al. | Mar 2004 | A1 |
| 20040049226 | Keegan et al. | Mar 2004 | A1 |
| 20040049262 | Obermiller et al. | Mar 2004 | A1 |
| 20040049266 | Anduiza et al. | Mar 2004 | A1 |
| 20040059409 | Stenzel | Mar 2004 | A1 |
| 20040073198 | Gilson et al. | Apr 2004 | A1 |
| 20040082904 | Houde et al. | Apr 2004 | A1 |
| 20040082967 | Broome et al. | Apr 2004 | A1 |
| 20040082989 | Cook et al. | Apr 2004 | A1 |
| 20040087982 | Eskuri | May 2004 | A1 |
| 20040088045 | Cox | May 2004 | A1 |
| 20040093016 | Root et al. | May 2004 | A1 |
| 20040093060 | Seguin et al. | May 2004 | A1 |
| 20040097788 | Mourlas et al. | May 2004 | A1 |
| 20040098022 | Barone | May 2004 | A1 |
| 20040098098 | McGuckin, Jr. et al. | May 2004 | A1 |
| 20040098099 | McCullagh et al. | May 2004 | A1 |
| 20040098112 | DiMatteo et al. | May 2004 | A1 |
| 20040107004 | Levine et al. | Jun 2004 | A1 |
| 20040111096 | Tu et al. | Jun 2004 | A1 |
| 20040116951 | Rosengart | Jun 2004 | A1 |
| 20040116999 | Ledergerber | Jun 2004 | A1 |
| 20040117004 | Osborne et al. | Jun 2004 | A1 |
| 20040117009 | Cali et al. | Jun 2004 | A1 |
| 20040122468 | Yodfat et al. | Jun 2004 | A1 |
| 20040122516 | Fogarty et al. | Jun 2004 | A1 |
| 20040127936 | Salahieh et al. | Jul 2004 | A1 |
| 20040127979 | Wilson et al. | Jul 2004 | A1 |
| 20040133274 | Webler et al. | Jul 2004 | A1 |
| 20040138694 | Tran et al. | Jul 2004 | A1 |
| 20040138742 | Myers et al. | Jul 2004 | A1 |
| 20040138743 | Myers et al. | Jul 2004 | A1 |
| 20040148018 | Carpentier et al. | Jul 2004 | A1 |
| 20040148021 | Cartledge et al. | Jul 2004 | A1 |
| 20040153094 | Dunfee et al. | Aug 2004 | A1 |
| 20040158277 | Lowe et al. | Aug 2004 | A1 |
| 20040167565 | Beulke et al. | Aug 2004 | A1 |
| 20040167620 | Ortiz et al. | Aug 2004 | A1 |
| 20040181140 | Falwell et al. | Sep 2004 | A1 |
| 20040186558 | Pavcnik et al. | Sep 2004 | A1 |
| 20040186563 | Lobbi | Sep 2004 | A1 |
| 20040193261 | Berreklouw | Sep 2004 | A1 |
| 20040197695 | Aono | Oct 2004 | A1 |
| 20040199245 | Lauterjung | Oct 2004 | A1 |
| 20040204755 | Robin | Oct 2004 | A1 |
| 20040210304 | Seguin et al. | Oct 2004 | A1 |
| 20040210306 | Quijano et al. | Oct 2004 | A1 |
| 20040210307 | Khairkhahan | Oct 2004 | A1 |
| 20040215331 | Chew et al. | Oct 2004 | A1 |
| 20040215333 | Duran et al. | Oct 2004 | A1 |
| 20040215339 | Drasler et al. | Oct 2004 | A1 |
| 20040220655 | Swanson et al. | Nov 2004 | A1 |
| 20040225321 | Krolik et al. | Nov 2004 | A1 |
| 20040225353 | McGuckin, Jr. et al. | Nov 2004 | A1 |
| 20040225354 | Allen et al. | Nov 2004 | A1 |
| 20040225355 | Stevens | Nov 2004 | A1 |
| 20040243221 | Fawzi et al. | Dec 2004 | A1 |
| 20040254636 | Flagle et al. | Dec 2004 | A1 |
| 20040260390 | Sarac et al. | Dec 2004 | A1 |
| 20050010287 | Macoviak et al. | Jan 2005 | A1 |
| 20050021136 | Xie et al. | Jan 2005 | A1 |
| 20050033398 | Seguin | Feb 2005 | A1 |
| 20050033402 | Cully et al. | Feb 2005 | A1 |
| 20050043711 | Corcoran et al. | Feb 2005 | A1 |
| 20050043757 | Arad et al. | Feb 2005 | A1 |
| 20050043790 | Seguin | Feb 2005 | A1 |
| 20050049692 | Numamoto et al. | Mar 2005 | A1 |
| 20050049696 | Siess et al. | Mar 2005 | A1 |
| 20050055088 | Liddicoat et al. | Mar 2005 | A1 |
| 20050060016 | Wu et al. | Mar 2005 | A1 |
| 20050060029 | Le et al. | Mar 2005 | A1 |
| 20050065594 | DiMatteo et al. | Mar 2005 | A1 |
| 20050075584 | Cali | Apr 2005 | A1 |
| 20050075662 | Pedersen et al. | Apr 2005 | A1 |
| 20050075712 | Biancucci et al. | Apr 2005 | A1 |
| 20050075717 | Nguyen et al. | Apr 2005 | A1 |
| 20050075719 | Bergheim | Apr 2005 | A1 |
| 20050075724 | Svanidze et al. | Apr 2005 | A1 |
| 20050075730 | Myers et al. | Apr 2005 | A1 |
| 20050075731 | Artof et al. | Apr 2005 | A1 |
| 20050085841 | Eversull et al. | Apr 2005 | A1 |
| 20050085842 | Eversull et al. | Apr 2005 | A1 |
| 20050085843 | Opolski et al. | Apr 2005 | A1 |
| 20050085890 | Rasmussen et al. | Apr 2005 | A1 |
| 20050090846 | Pedersen et al. | Apr 2005 | A1 |
| 20050090890 | Wu et al. | Apr 2005 | A1 |
| 20050096692 | Linder et al. | May 2005 | A1 |
| 20050096734 | Majercak et al. | May 2005 | A1 |
| 20050096735 | Hojeibane et al. | May 2005 | A1 |
| 20050096736 | Osse et al. | May 2005 | A1 |
| 20050096738 | Cali et al. | May 2005 | A1 |
| 20050100580 | Osborne et al. | May 2005 | A1 |
| 20050107822 | Wasdyke | May 2005 | A1 |
| 20050113910 | Paniagua et al. | May 2005 | A1 |
| 20050131438 | Cohn | Jun 2005 | A1 |
| 20050137683 | Hezi-Yamit et al. | Jun 2005 | A1 |
| 20050137686 | Salahieh et al. | Jun 2005 | A1 |
| 20050137687 | Salahieh et al. | Jun 2005 | A1 |
| 20050137688 | Salahieh et al. | Jun 2005 | A1 |
| 20050137689 | Salahieh et al. | Jun 2005 | A1 |
| 20050137690 | Salahieh et al. | Jun 2005 | A1 |
| 20050137691 | Salahieh et al. | Jun 2005 | A1 |
| 20050137692 | Haug et al. | Jun 2005 | A1 |
| 20050137693 | Haug et al. | Jun 2005 | A1 |
| 20050137694 | Haug et al. | Jun 2005 | A1 |
| 20050137695 | Salahieh et al. | Jun 2005 | A1 |
| 20050137696 | Salahieh et al. | Jun 2005 | A1 |
| 20050137697 | Salahieh et al. | Jun 2005 | A1 |
| 20050137698 | Salahieh et al. | Jun 2005 | A1 |
| 20050137699 | Salahieh et al. | Jun 2005 | A1 |
| 20050137701 | Salahieh et al. | Jun 2005 | A1 |
| 20050137702 | Haug et al. | Jun 2005 | A1 |
| 20050138689 | Aukerman | Jun 2005 | A1 |
| 20050143807 | Pavcnik et al. | Jun 2005 | A1 |
| 20050143809 | Salahieh et al. | Jun 2005 | A1 |
| 20050149159 | Andreas et al. | Jul 2005 | A1 |
| 20050165352 | Henry et al. | Jul 2005 | A1 |
| 20050165477 | Anduiza et al. | Jul 2005 | A1 |
| 20050165479 | Drews et al. | Jul 2005 | A1 |
| 20050182486 | Gabbay | Aug 2005 | A1 |
| 20050197694 | Pai et al. | Sep 2005 | A1 |
| 20050197695 | Stacchino et al. | Sep 2005 | A1 |
| 20050203549 | Realyvasquez | Sep 2005 | A1 |
| 20050203614 | Forster et al. | Sep 2005 | A1 |
| 20050203615 | Forster et al. | Sep 2005 | A1 |
| 20050203616 | Cribier | Sep 2005 | A1 |
| 20050203617 | Forster et al. | Sep 2005 | A1 |
| 20050203618 | Sharkawy et al. | Sep 2005 | A1 |
| 20050203818 | Rotman et al. | Sep 2005 | A9 |
| 20050209580 | Freyman | Sep 2005 | A1 |
| 20050228472 | Case et al. | Oct 2005 | A1 |
| 20050228495 | Macoviak | Oct 2005 | A1 |
| 20050234546 | Nugent et al. | Oct 2005 | A1 |
| 20050240200 | Bergheim | Oct 2005 | A1 |
| 20050240262 | White | Oct 2005 | A1 |
| 20050251250 | Verhoeven et al. | Nov 2005 | A1 |
| 20050251251 | Cribier | Nov 2005 | A1 |
| 20050261759 | Lambrecht et al. | Nov 2005 | A1 |
| 20050267560 | Bates | Dec 2005 | A1 |
| 20050283231 | Haug et al. | Dec 2005 | A1 |
| 20050283962 | Boudjemline | Dec 2005 | A1 |
| 20060004439 | Spenser et al. | Jan 2006 | A1 |
| 20060004442 | Spenser et al. | Jan 2006 | A1 |
| 20060015168 | Gunderson | Jan 2006 | A1 |
| 20060025857 | Bergheim et al. | Feb 2006 | A1 |
| 20060058872 | Salahieh et al. | Mar 2006 | A1 |
| 20060149360 | Schwammenthal et al. | Jul 2006 | A1 |
| 20060155312 | Levine et al. | Jul 2006 | A1 |
| 20060161249 | Realyvasquez et al. | Jul 2006 | A1 |
| 20060173524 | Salahieh et al. | Aug 2006 | A1 |
| 20060195183 | Navia et al. | Aug 2006 | A1 |
| 20060253191 | Salahieh et al. | Nov 2006 | A1 |
| 20060259134 | Schwammenthal et al. | Nov 2006 | A1 |
| 20060271166 | Thill et al. | Nov 2006 | A1 |
| 20060287668 | Fawzi et al. | Dec 2006 | A1 |
| 20060287717 | Rowe et al. | Dec 2006 | A1 |
| 20070010876 | Salahieh et al. | Jan 2007 | A1 |
| 20070010877 | Salahieh et al. | Jan 2007 | A1 |
| 20070016286 | Herrmann et al. | Jan 2007 | A1 |
| 20070055340 | Pryor | Mar 2007 | A1 |
| 20070061008 | Salahieh et al. | Mar 2007 | A1 |
| 20070088431 | Bourang et al. | Apr 2007 | A1 |
| 20070100427 | Perouse | May 2007 | A1 |
| 20070112355 | Salahieh et al. | May 2007 | A1 |
| 20070118214 | Salahieh et al. | May 2007 | A1 |
| 20070162107 | Haug et al. | Jul 2007 | A1 |
| 20070173918 | Dreher et al. | Jul 2007 | A1 |
| 20070203503 | Salahieh et al. | Aug 2007 | A1 |
| 20070244552 | Salahieh et al. | Oct 2007 | A1 |
| 20070288089 | Gurskis et al. | Dec 2007 | A1 |
| 20080009940 | Cribier | Jan 2008 | A1 |
| 20080033541 | Gelbart et al. | Feb 2008 | A1 |
| 20080071363 | Tuval et al. | Mar 2008 | A1 |
| 20080082165 | Wilson et al. | Apr 2008 | A1 |
| 20080125859 | Salahieh et al. | May 2008 | A1 |
| 20080188928 | Salahieh et al. | Aug 2008 | A1 |
| 20080208328 | Antocci et al. | Aug 2008 | A1 |
| 20080208332 | Lamphere et al. | Aug 2008 | A1 |
| 20080221672 | Lamphere et al. | Sep 2008 | A1 |
| 20080234814 | Salahieh et al. | Sep 2008 | A1 |
| 20080255661 | Straubinger et al. | Oct 2008 | A1 |
| 20080269878 | Iobbi | Oct 2008 | A1 |
| 20080288054 | Pulnev et al. | Nov 2008 | A1 |
| 20090005863 | Goetz et al. | Jan 2009 | A1 |
| 20090030512 | Thielen et al. | Jan 2009 | A1 |
| 20090054969 | Salahieh et al. | Feb 2009 | A1 |
| 20090076598 | Salahieh et al. | Mar 2009 | A1 |
| 20090093877 | Keidar et al. | Apr 2009 | A1 |
| 20090096598 | Tengler et al. | Apr 2009 | A1 |
| 20090171456 | Kveen et al. | Jul 2009 | A1 |
| 20090216312 | Straubinger et al. | Aug 2009 | A1 |
| 20090222076 | Figulla et al. | Sep 2009 | A1 |
| 20090264759 | Byrd | Oct 2009 | A1 |
| 20090264997 | Salahieh et al. | Oct 2009 | A1 |
| 20090299462 | Fawzi et al. | Dec 2009 | A1 |
| 20100036479 | Hill et al. | Feb 2010 | A1 |
| 20100049313 | Alon et al. | Feb 2010 | A1 |
| 20100082089 | Quadri et al. | Apr 2010 | A1 |
| 20100094399 | Dorn et al. | Apr 2010 | A1 |
| 20100121434 | Paul et al. | May 2010 | A1 |
| 20100161045 | Righini | Jun 2010 | A1 |
| 20100185275 | Richter et al. | Jul 2010 | A1 |
| 20100191320 | Straubinger et al. | Jul 2010 | A1 |
| 20100191326 | Alkhatib | Jul 2010 | A1 |
| 20100219092 | Salahieh et al. | Sep 2010 | A1 |
| 20100249908 | Chau et al. | Sep 2010 | A1 |
| 20100268332 | Tuval et al. | Oct 2010 | A1 |
| 20100280495 | Paul et al. | Nov 2010 | A1 |
| 20100298931 | Quadri et al. | Nov 2010 | A1 |
| 20110040366 | Goetz et al. | Feb 2011 | A1 |
| 20110098805 | Dwork et al. | Apr 2011 | A1 |
| 20110218619 | Benichou et al. | Sep 2011 | A1 |
| 20110257735 | Salahieh et al. | Oct 2011 | A1 |
| 20110264191 | Rothstein | Oct 2011 | A1 |
| 20110264196 | Savage et al. | Oct 2011 | A1 |
| 20110264203 | Dwork et al. | Oct 2011 | A1 |
| 20110276129 | Salahieh et al. | Nov 2011 | A1 |
| 20110288634 | Tuval et al. | Nov 2011 | A1 |
| 20110295363 | Girard et al. | Dec 2011 | A1 |
| 20110319989 | Lane et al. | Dec 2011 | A1 |
| 20120016469 | Salahieh et al. | Jan 2012 | A1 |
| 20120016471 | Salahieh et al. | Jan 2012 | A1 |
| 20120022633 | Olson et al. | Jan 2012 | A1 |
| 20120022642 | Haug et al. | Jan 2012 | A1 |
| 20120029627 | Salahieh et al. | Feb 2012 | A1 |
| 20120041549 | Salahieh et al. | Feb 2012 | A1 |
| 20120041550 | Salahieh et al. | Feb 2012 | A1 |
| 20120046740 | Paul et al. | Feb 2012 | A1 |
| 20120053683 | Salahieh et al. | Mar 2012 | A1 |
| 20120089224 | Haug et al. | Apr 2012 | A1 |
| 20120132547 | Salahieh et al. | May 2012 | A1 |
| 20120179244 | Schankereli et al. | Jul 2012 | A1 |
| 20120197379 | Laske et al. | Aug 2012 | A1 |
| 20120303113 | Benichou et al. | Nov 2012 | A1 |
| 20120303116 | Gorman et al. | Nov 2012 | A1 |
| 20120330409 | Haug et al. | Dec 2012 | A1 |
| 20130013057 | Salahieh et al. | Jan 2013 | A1 |
| 20130018457 | Gregg et al. | Jan 2013 | A1 |
| 20130030520 | Lee et al. | Jan 2013 | A1 |
| 20130079867 | Hoffman et al. | Mar 2013 | A1 |
| 20130079869 | Straubinger et al. | Mar 2013 | A1 |
| 20130096664 | Goetz et al. | Apr 2013 | A1 |
| 20130123796 | Sutton et al. | May 2013 | A1 |
| 20130138207 | Quadri et al. | May 2013 | A1 |
| 20130158656 | Sutton et al. | Jun 2013 | A1 |
| 20130166017 | Cartledge et al. | Jun 2013 | A1 |
| 20130184813 | Quadri et al. | Jul 2013 | A1 |
| 20130190865 | Anderson | Jul 2013 | A1 |
| 20130204360 | Gainor | Aug 2013 | A1 |
| 20130253640 | Meiri et al. | Sep 2013 | A1 |
| 20130289698 | Wang et al. | Oct 2013 | A1 |
| 20130296999 | Burriesci et al. | Nov 2013 | A1 |
| 20130304199 | Sutton et al. | Nov 2013 | A1 |
| 20130310917 | Richter et al. | Nov 2013 | A1 |
| 20130310923 | Kheradvar et al. | Nov 2013 | A1 |
| 20140018911 | Zhou et al. | Jan 2014 | A1 |
| 20140031924 | Bruchman et al. | Jan 2014 | A1 |
| 20140094904 | Salahieh et al. | Apr 2014 | A1 |
| 20140114340 | Zhou et al. | Apr 2014 | A1 |
| 20140114405 | Paul et al. | Apr 2014 | A1 |
| 20140114406 | Salahieh et al. | Apr 2014 | A1 |
| 20140121766 | Salahieh et al. | May 2014 | A1 |
| 20140135912 | Salahieh et al. | May 2014 | A1 |
| 20140243967 | Salahieh et al. | Aug 2014 | A1 |
| 20140324160 | Benichou et al. | Oct 2014 | A1 |
| 20150012085 | Salahieh et al. | Jan 2015 | A1 |
| 20150073540 | Salahieh et al. | Mar 2015 | A1 |
| 20150073541 | Salahieh et al. | Mar 2015 | A1 |
| 20150127094 | Salahieh et al. | May 2015 | A1 |
| 20150245909 | Salahieh et al. | Sep 2015 | A1 |
| 20160045307 | Yohanan et al. | Feb 2016 | A1 |
| 20160143731 | Backus et al. | May 2016 | A1 |
| 20160157998 | Bruchman et al. | Jun 2016 | A1 |
| 20160199184 | Ma et al. | Jul 2016 | A1 |
| 20160213467 | Backus et al. | Jul 2016 | A1 |
| 20160220359 | Backus et al. | Aug 2016 | A1 |
| 20160220360 | Lin et al. | Aug 2016 | A1 |
| 20160256271 | Backus et al. | Sep 2016 | A1 |
| 20160296322 | Edelman et al. | Oct 2016 | A1 |
| 20170042669 | Backus | Feb 2017 | A1 |
| 20170042671 | Backus et al. | Feb 2017 | A1 |
| 20170042672 | Backus et al. | Feb 2017 | A1 |
| 20170042676 | Backus et al. | Feb 2017 | A1 |
| 20170071729 | Wrobel | Mar 2017 | A1 |
| 20170304049 | Hayes | Oct 2017 | A1 |
| 20170319335 | Backus et al. | Nov 2017 | A1 |
| 20170325928 | Ino et al. | Nov 2017 | A1 |
| Number | Date | Country |
|---|---|---|
| 2002329324 | Jul 2007 | AU |
| 1338951 | Mar 2002 | CN |
| 19532846 | Mar 1997 | DE |
| 19546692 | Jun 1997 | DE |
| 19857887 | Jul 2000 | DE |
| 19907646 | Aug 2000 | DE |
| 10049812 | Apr 2002 | DE |
| 10049813 | Apr 2002 | DE |
| 10049814 | Apr 2002 | DE |
| 10049815 | Apr 2002 | DE |
| 0103546 | May 1988 | EP |
| 0144167 | Nov 1989 | EP |
| 579523 | Jan 1994 | EP |
| 0409929 | Apr 1997 | EP |
| 0850607 | Jul 1998 | EP |
| 0597967 | Dec 1999 | EP |
| 1000590 | May 2000 | EP |
| 1057459 | Dec 2000 | EP |
| 1057460 | Dec 2000 | EP |
| 1088529 | Apr 2001 | EP |
| 0937439 | Sep 2003 | EP |
| 1340473 | Sep 2003 | EP |
| 1356793 | Oct 2003 | EP |
| 1042045 | May 2004 | EP |
| 0819013 | Jun 2004 | EP |
| 1430853 | Jun 2004 | EP |
| 1435879 | Jul 2004 | EP |
| 1439800 | Jul 2004 | EP |
| 1472996 | Nov 2004 | EP |
| 1229864 | Apr 2005 | EP |
| 1059894 | Jul 2005 | EP |
| 1551274 | Jul 2005 | EP |
| 1551336 | Jul 2005 | EP |
| 1078610 | Aug 2005 | EP |
| 1562515 | Aug 2005 | EP |
| 1570809 | Sep 2005 | EP |
| 1576937 | Sep 2005 | EP |
| 1582178 | Oct 2005 | EP |
| 1582179 | Oct 2005 | EP |
| 1469797 | Nov 2005 | EP |
| 1589902 | Nov 2005 | EP |
| 1600121 | Nov 2005 | EP |
| 1156757 | Dec 2005 | EP |
| 1616531 | Jan 2006 | EP |
| 1690515 | Aug 2006 | EP |
| 1605871 | Jul 2008 | EP |
| 2047824 | May 2012 | EP |
| 2749254 | Jun 2015 | EP |
| 2926766 | Oct 2015 | EP |
| 2788217 | Jul 2000 | FR |
| 2056023 | Mar 1981 | GB |
| 2398245 | Aug 2004 | GB |
| 1271508 | Nov 1986 | SU |
| 1371700 | Feb 1988 | SU |
| 9117720 | Nov 1991 | WO |
| 9217118 | Oct 1992 | WO |
| 9301768 | Feb 1993 | WO |
| 9315693 | Aug 1993 | WO |
| 9504556 | Feb 1995 | WO |
| 9529640 | Nov 1995 | WO |
| 9614032 | May 1996 | WO |
| 9624306 | Aug 1996 | WO |
| 9640015 | Dec 1996 | WO |
| 9748350 | Dec 1997 | WO |
| 9829057 | Jul 1998 | WO |
| 9836790 | Aug 1998 | WO |
| 9850103 | Nov 1998 | WO |
| 9855047 | Dec 1998 | WO |
| 9857599 | Dec 1998 | WO |
| 9933414 | Jul 1999 | WO |
| 9940964 | Aug 1999 | WO |
| 9944542 | Sep 1999 | WO |
| 9947075 | Sep 1999 | WO |
| 9951165 | Oct 1999 | WO |
| 0009059 | Feb 2000 | WO |
| 2000009059 | Feb 2000 | WO |
| 0041652 | Jul 2000 | WO |
| 0044308 | Aug 2000 | WO |
| 0044311 | Aug 2000 | WO |
| 0044313 | Aug 2000 | WO |
| 0045874 | Aug 2000 | WO |
| 0047139 | Aug 2000 | WO |
| 0049970 | Aug 2000 | WO |
| 0067661 | Nov 2000 | WO |
| 0105331 | Jan 2001 | WO |
| 0106959 | Feb 2001 | WO |
| 0108596 | Feb 2001 | WO |
| 0110320 | Feb 2001 | WO |
| 0110343 | Feb 2001 | WO |
| 0135870 | May 2001 | WO |
| 0149213 | Jul 2001 | WO |
| 0154625 | Aug 2001 | WO |
| 0162189 | Aug 2001 | WO |
| 2001054625 | Aug 2001 | WO |
| 0164137 | Sep 2001 | WO |
| 0176510 | Oct 2001 | WO |
| 0197715 | Dec 2001 | WO |
| 0236048 | May 2002 | WO |
| 0241789 | May 2002 | WO |
| 0243620 | Jun 2002 | WO |
| 0247575 | Jun 2002 | WO |
| 02056955 | Jul 2002 | WO |
| 02069842 | Sep 2002 | WO |
| 02100297 | Dec 2002 | WO |
| 03003943 | Jan 2003 | WO |
| 03003949 | Jan 2003 | WO |
| 03011195 | Feb 2003 | WO |
| 03028592 | Apr 2003 | WO |
| 03030776 | Apr 2003 | WO |
| 03032869 | Apr 2003 | WO |
| 03037222 | May 2003 | WO |
| 03037227 | May 2003 | WO |
| 03047468 | Jun 2003 | WO |
| 03047648 | Jun 2003 | WO |
| 03088873 | Oct 2003 | WO |
| 03015851 | Nov 2003 | WO |
| 03094793 | Nov 2003 | WO |
| 03094797 | Nov 2003 | WO |
| 03096932 | Nov 2003 | WO |
| 2004006803 | Jan 2004 | WO |
| 2004006804 | Jan 2004 | WO |
| 2004014256 | Feb 2004 | WO |
| 2004019811 | Mar 2004 | WO |
| 2004019817 | Mar 2004 | WO |
| 2004021922 | Mar 2004 | WO |
| 2004023980 | Mar 2004 | WO |
| 2004026117 | Apr 2004 | WO |
| 2004041126 | May 2004 | WO |
| 2004043293 | May 2004 | WO |
| 2004047681 | Jun 2004 | WO |
| 2004058106 | Jul 2004 | WO |
| 2004066876 | Aug 2004 | WO |
| 2004082536 | Sep 2004 | WO |
| 2004089250 | Oct 2004 | WO |
| 2004089253 | Oct 2004 | WO |
| 2004093728 | Nov 2004 | WO |
| 2004105651 | Dec 2004 | WO |
| 2005002466 | Jan 2005 | WO |
| 2005004753 | Jan 2005 | WO |
| 2005009285 | Feb 2005 | WO |
| 2005011534 | Feb 2005 | WO |
| 2005011535 | Feb 2005 | WO |
| 2005023155 | Mar 2005 | WO |
| 2005027790 | Mar 2005 | WO |
| 2005046528 | May 2005 | WO |
| 2005046529 | May 2005 | WO |
| 2005048883 | Jun 2005 | WO |
| 2005062980 | Jul 2005 | WO |
| 2005065585 | Jul 2005 | WO |
| 2005084595 | Sep 2005 | WO |
| 2005087140 | Sep 2005 | WO |
| 2005096993 | Oct 2005 | WO |
| 2006005015 | Jan 2006 | WO |
| 2006009690 | Jan 2006 | WO |
| 2006027499 | Mar 2006 | WO |
| 2006093795 | Sep 2006 | WO |
| 2006138391 | Dec 2006 | WO |
| 2007009117 | Jan 2007 | WO |
| 2007033093 | Mar 2007 | WO |
| 2007035471 | Mar 2007 | WO |
| 2005102015 | Apr 2007 | WO |
| 2007044285 | Apr 2007 | WO |
| 2007053243 | Apr 2007 | WO |
| 2007058847 | May 2007 | WO |
| 2007092354 | Aug 2007 | WO |
| 2007097983 | Aug 2007 | WO |
| 2008028569 | Mar 2008 | WO |
| 2008035337 | Mar 2008 | WO |
| 2010042950 | Apr 2010 | WO |
| 2010098857 | Sep 2010 | WO |
| 2012116368 | Aug 2012 | WO |
| 2012162228 | Nov 2012 | WO |
| 2013009975 | Jan 2013 | WO |
| 2013028387 | Feb 2013 | WO |
| 2013074671 | May 2013 | WO |
| 2013096545 | Jun 2013 | WO |
| 2016126511 | Aug 2016 | WO |
| Entry |
|---|
| US 8,062,356 B2, 11/2011, Salahieh et al. (withdrawn) |
| US 8,062,357 B2, 11/2011, Salahieh et al. (withdrawn) |
| US 8,075,614 B2, 12/2011, Salahieh et al. (withdrawn) |
| US 8,133,271 B2, 03/2012, Salahieh et al. (withdrawn) |
| US 8,211,170 B2, 07/2012, Paul et al. (withdrawn) |
| International Search Report and Written Opinion dated Jul. 28, 2017 for International Application No. PCT/US2017/032284. |
| Cribier et al., “Percutaneous Transluminal Valvuloplasty of Acquired Aortic Stenosis in Elderly Patients: An Alternative to Valve Replacement?” The Lancet, 63-7 (Jan. 11, 1986). |
| Supplemental Search Report from EP Patent Office, EP Application No. 04813777.2, dated Aug. 19, 2011. |
| Laborde et al., “Percutaneous Implantation of the Corevalve Aortic Valve Prosthesis for Patients Presenting High Risk for Surgical Valve Replacement.” EuroIntervention: 472-474, Feb. 2006. |
| “A Matter of Size.” Triennial Review of the National Nanotechnology Initiative, The National Academies Press, Washington DC, v-13, http://www.nap.edu/catalog/11752/a-matter-of-size-triennial-review-of-the-national-nanotechnology, 2006. |
| “Heart Valve Materials—Bovine (cow).” Equine & Porcine Pericardium, Maverick Biosciences Pty. Lt, http://maverickbio.com/biological-medical-device-materials.php?htm. 2009. |
| “Pericardial Heart Valves.” Edwards Lifesciences, Cardiovascular Surgery FAQ, http://www.edwards.com/products/cardiovascularsurgeryfaq.htm, Nov. 14, 2010. |
| Allen et al., “What are the characteristics of the ideal endovascular graft for abdominal aortic aneurysm exclusion?” J. Endovasc. Surg., 4(2):195-202 (May 1997). |
| Andersen et al. “Transluminal catheter implantation of a new expandable artificial cardiac valve (the stent—valve) in the aorta and the beating heart of closed chest pigs (Abstract).” Eur. Heart J., 11 (Suppl.): 224a (1990). |
| Andersen et al., “Transluminal implantation of artificial heart valves. Description of a new expandable aortic valve and initial results with implantation by catheter technique in closed chest pigs.” Euro. Heart J., 13:704-708, May 1992. |
| Atwood et al., “Insertion of Heart Valves by Catheterization.” Project Supervised by Prof. S. Muftu of Northeastern University 2001-2002: 36-40, May 30, 2002. |
| Atwood et al., “Insertion of Heart Valves by Catheterization.” The Capstone Design Course Report. MIME 1501-1502. Technical Design Report. Northeastern University, pp. 1-93, Nov. 5, 2007. |
| Bailey, “Percutaneous Expandable Prosthetic Valves, Textbook of Interventional Cardiology.” vol. 2, 2d ed. Eric J. Topol, W.B. Saunders Co. (1994). |
| Blum et al., “Endoluminal Stent—Grafts for Intrarenal Abdominal Aortic Aneurysms.” New Engl. J. Med., 336:13-20 (1997). |
| Bodnar et al., “Replacement Cardiac Valves R Chapter 13: Extinct Cardiac Valve Prostheses.” Pergamon Publishing Corporation. New York, 307-322, 1991. |
| Bonhoeffer et al., “Percutaneous Insertion of the Pulmonary Valve.” J. Am. Coll. Cardiol., 39:1664-9 (2002). |
| Bonhoeffer et al., “Transcatheter Implantation of a Bovine Valve in Pulmonary Position: A Lamb Study.” Circulation, 102: 813-16 (2000). |
| Bonhoeffer, et al., “Percutaneous replacement of pulmonary valve in a right ventricle to pulmonary-artery prosthetic conduit with valve dysfunction.” The Lancet, vol. 356, 1403-05 (Oct. 21, 2000). |
| Boudjemline et al., “Percutaneous Implantation of a Biological Valve in the Aorta to Treat Aortic Valve Insufficiency—A Sheep Study.” Med Sci. Monit., vol. 8, No. 4: BR113-116, Apr. 12, 2002. |
| Boudjemline et al., “Percutaneous Implantation of a Valve in the Descending Aorta in Lambs.” Euro. Heart J., 23: 1045-1049, Jul. 2002. |
| Boudjemline et al., “Percutaneous Pulmonary Valve Replacement in a Large Right Ventricular Outflow Tract: An Experimental Study.” Journal of the American College of Cardiology, vol. 43(6): 1082-1087, Mar. 17, 2004. |
| Boudjemline et al., “Percutaneous Valve Insertion: A New Approach?” J. of Thoracic and Cardio. Surg, 125(3): 741-743, Mar. 2003. |
| Boudjemline et al., “Steps Toward Percutaneous Aortic Valve Replacement.” Circulation, 105: 775-778, Feb. 12, 2002. |
| Carpentier-Edwards PERIMOUNT Bioprosthesis (2003). |
| Couper, “Surgical Aspects of Prosthetic Valve Selection,” Overview of Cardiac Surgery for the Cardiologist, Springer-Verlag New York, Inc., 131-145 (1994). |
| Cribier et al., “Early Experience with Percutaneous Transcatheter Implantation of Heart Valve Prosthesis for the Treatment of End-Stage Inoperable Patients with Calcific Aortic Stenosis.” J. of Am. Coll. of Cardio, 43(4): 698-703, Feb. 18, 2004. |
| Cribier et al., “Percutaneous Transcatheter Implantation of an Aortic Valve Prosthesis for Calcific Aortic Stenosis: First Human Case.” Percutaneous Valve Technologies, Inc., 16 pages, Apr. 16, 2002. |
| Cribier et al., “Percutaneous Transcatheter Implementation of an Aortic Valve Prosthesis for Calcific Aortic Stenosis: First Human Case Description.” Circulation, 106: 3006-3008, Dec. 10, 2002. |
| Cribier et al., “Trans-Cathether Implantation of Balloon-Expandable Prosthetic Heart Valves: Early Results in an Animal Model.” Circulation [suppl. II] 104(17) II-552 (Oct. 23, 2001). |
| Cunanan et al., “Tissue Characterization and Calcification Potential of Commercial Bioprosthetic Heart Valves.” Ann. Thorac. Surg., S417-421, May 15, 2001. |
| Cunliffe et al., “Glutaraldehyde Inactivation of Exotic Animal Viruses in Swine Heart Tissue.” Applied and Environmental Microbiology, Greenport, New York, 37(5): 1044-1046, May 1979. |
| Dake et al., “Transluminal Placement of Endovascular Stent-Grafts for the Treatment of Descending Thoracic Aortic Aneurysms.” New Engl. J. of Med., 331(26):1729-34 (1994). |
| Dalby et al., “Non-Surgical Aortic Valve Replacement” Br. J. Cardiol., 10:450-2 (2003). |
| Dhasmana, et al., “Factors Associated With Periprosthetic Leakage Following Primary Mitral Valve Replacement: With Special Consideration of Suture Technique.” Annals of Thorac. Surg. 35(2), 170-8 (Feb. 1983). |
| Diethrich, AAA Stent Grafts: Current Developments, J. Invasive Cardiol. 13(5) (2001). |
| Dolmatch et al., Stent Grafts: Current Clinical Practice (2000)—EVT Endograft and Talent Endoprosthesis. |
| Dotter, “Transluminally-Placed Coilspring Endarterial Tube Grafts,” Investigative Radiology, pp. 329-332 (1969). |
| Emery et al., “Replacement of the Aortic Valve in Patients Under 50 Years of Age: Long-Term Follow-Up of the St. Jude Medical Prosthesis.” Ann. Thorac. Surg., 75:1815-9 (2003). |
| EP Search Report for EP Application No. 06824992.9, dated Aug. 10, 2011. |
| Examiner's First Report on AU Patent Application No. 2011202667, dated May 17, 2012. |
| Ferrari et al., “Percutaneous Transvascular Aortic Valve Replacement with Self-Expanding Stent-Valve Device.” Poster from the presentation given at SMIT 2000, 12th International Conference. Sep. 5, 2000. |
| Fluency Vascular Stent Graft Instructions for Use (2003). |
| Greenberg, “Abdominal Aortic Endografting: Fixation and Sealing.” J. Am. Coll. Surg. 194:1:S79-S87 (2002). |
| Grossi, “Impact of Minimally Invasive Valvular Heart Surgery: A Case-Control Study.” Ann. Thorac. Surg., 71:807-10 (2001). |
| Helmus, “Mechanical and Bioprosthetic Heart Valves in Biomaterials for Artificial Organs.” Woodhead Publishing Limited: 114-162, 2011. |
| Hijazi, “Transcatheter Valve Replacement: A New Era of Percutaneous Cardiac Intervention Begins.” J. of Am. College of Cardio., 43(6): 1088-1089, Mar. 17, 2004. |
| Hourihan et al., “Transcatheter Umbrella Closure of Valvular and Paravalvular Leaks.” JACC, Boston, Massachusetts, 20(6): 1371-1377, Nov. 15, 1992. |
| Huber et al., “Do Valved Stents Compromise Coronary Flow?” European Journal of Cardio-thoracic Surgery, vol. 25: 754-759, Jan. 23, 2004. |
| Ing, “Stents: What's Available to the Pediatric Interventional Cardiologist?” Catheterization and Cardiovascular Interventions 57:274-386 (2002). |
| Ionescu, et al., “Prevalence and Clinical Significance of Incidental Paraprosthetic Valvar Regurgitation: A prospective study using transesophageal echocardiography.” Heart, 89:1316-21 (2003). |
| Kaiser, et al., “Surgery for Left Ventricle Outflow Obstruction: Aortic Valve Replacement and Myomectomy,” Overview of Cardiac Surgery for the Cardiologist. Springer-Verlag New York, Inc., 40-45 (1994). |
| Gore Excluder Instructions for Use (2002). |
| U.S. Appl. No. 60/553,945 to White, filed Mar. 18, 2004. |
| Kato et al., “Traumatic Thoracic Aortic Aneurysm: Treatment with Endovascular Stent-Grafts.” Radiol., 205: 657-662 (1997). |
| Khonsari et al., “Cardiac Surgery: Safeguards and Pitfalls in Operative Technique.” 3d ed., 45-74 (2003). |
| Knudsen et al., “Catheter-implanted prosthetic heart valves.” Int'l J. of Art. Organs, 16(5): 253-262, May 1993. |
| Kort et al., “Minimally Invasive Aortic Valve Replacement: Echocardiographic and Clinical Results.” Am. Heart J., 142(3): 476-481, Sep. 2001. |
| Lawrence et al., “Percutaneous Endovascular Graft: Experimental Evaluation,” Radiology, 163(2): 357-60 (May 1987). |
| Levi et al., “Future of Interventional Cardiology in Pediactrics.” Current Opinion in Cardiol., 18:79-90 (2003). |
| Levy, “Mycobacterium Chelonei Infection of Porcine Heart Valves.” The New England Journal of Medicine, Washington DC, 297(12), Sep. 22, 1977. |
| Love et al., The Autogenous Tissue Heart Valve: Current Status. Journal of Cardiac Surgery, 6(4): 499-507, Mar. 1991. |
| Lutter et al., “Percutaneous Aortic Valve Replacement: An Experimental Study. I. Studies on Implantation.” J. of Thoracic and Cardio. Surg., 123(4): 768-776, Apr. 2002. |
| Magovern et al., “Twenty-five-Year Review of the Magovern-Cromie Sutureless Aortic Valve.” Ann. Thorac. Surg., 48: S33-4 (1989). |
| Maraj et al., Evaluation of Hemolysis in Patients with Prosthetic Heart Valves, Clin. Cardiol. 21, 387-392 (1998). |
| Mckay et al., “The Mansfield Scientific Aortic Valvuloplasty Registry: Overview of Acute Hemodynamic Results and Procedural Complications.” J. Am. Coll. Cardiol. 17(2): 485-91 (Feb. 1991). |
| Mirich et al., “Percutaneously Placed Endovascular Grafts for Aortic Aneurysms: Feasibility Study.” Radiology, 170: 1033-1037 (1989). |
| Moazami et al., “Transluminal Aortic Valve Placement: A Feasibility Study With a Newly Designed Collapsiable Aortic Valve,” ASAIO J. vol. 42:5, pp. M383-85 (Sep./Oct. 1996). |
| Moulopoulos et al., “Catheter-Mounted Aortic Valves.” Annals of Thoracic Surg., 11(5): 423-430, May 1971. |
| Paniagua et al., “Heart Watch.” Texas Heart Institute. Edition: 8 pages, Spring, 2004. |
| Paniagua et al., “Percutaneous Heart Valve in the Chronic in Vitro Testing Model.” Circulation, 106: e51-e52, Sep. 17, 2002. |
| Parodi et al., “Transfemoral Intraluminal Graft Implantation for Abdominal Aortic Aneurysms.” Ann. Vasc. Surg., 5 (6):491-9 (1991). |
| Pavcnik et al., “Percutaneous Bioprosthetic Venous Valve: A Long-term Study in Sheep.” J. of Vascular Surg., 35(3): 598-603, Mar. 2002. |
| Pavcnik et al., “Development and Initial Experimental Evaluation of a Prosthetic Aortic Valve for Transcatheter Placement.” Radiology 183:151-54 (1992). |
| Pavcnik, et al., “Aortic and venous valve for percutaneous insertion,” Min. Invas. Ther. & Allied Technol. 9(3/4) 287-292 (2000). |
| Phillips et al., “A Temporary Catheter-Tip Aortic Valve: Hemodynamic Effects on Experimental Acute Aortic Insufficiency.” Annals of Thoracic Surg., 21(2): 134-136, Feb. 1976. |
| Printz, et al., “Let the Blood Circulate.” Sulzer Tech. Rev. 4/99. |
| Raillat et al., “Treatment of Iliac Artery Stenosis with the Wallstent Endoprosthesis.” AJR 154(3):613-6 (Mar. 1990). |
| Remadi et al., “Preliminary results of 130 aortic valve replacements with a new mechanical bileaflet prosthesis: the Edwards MIRA valve” Interactive Cardiovasc. and Thorac. Surg. 2, 80-83 (2003). |
| Rosch et al., “Gianturco-Rosch Expandable Z-Stents in the Treatment of Superior Vena Cava Syndrome.” Cardiovasc. Intervent. Radiol. 15: 319-327 (1992). |
| Schurink et al,. “Stent Attachment Site—related Endoleakage after Stent Graft Treatment: An in vitro study of the effects of graft size, stent type, and atherosclerotic wall changes.” J. Vasc. Surg., 30(4):658-67 (Oct. 1999). |
| Seminars in Interventional Cardiology, ed. P.W. Surruys, vol. 5 (2000). |
| Sochman et al., “Percutaneous Transcatheter Aortic Disc Valve Prosthesis Implantation: A Feasibility Study.” Cardiovasc. Intervent. Radiol., 23: 384-388, Sep. 2000. |
| Southern Lights Biomaterials Homepage, http://www.slv.co.nz/, Jan. 7, 2011. |
| Stanley et al., “Evaluation of Patient Selection Guidelines for Endoluminal AAA Repair With the Zenith Stent Graft: The Australasian Experience.” J. Endovasc. Ther. 8:457-464 (2001). |
| Stassano, “Mid-term Results of the Valve-on-Valve Technique for Bioprosthetic Failure.” European Journal of Cardiothoracic Surgery: vol. 18, 453-457, Oct. 2000. |
| Steinhoff et al., “Tissue Engineering of Pulmonary Heart Valves on Allogenic Acellular Matrix Conduits.” Circulation, 102 [suppl. III]: III-50-III-55 (2000). |
| Stuart, “In Heart Valves, A Brave, New Non-Surgical World.” Start-Up. Feb. 9-17, 2004. |
| Supplemental Search Report from EP Patent Office, EP Application No. 04815634.3, dated Aug. 19, 2011. |
| Supplemental Search Report from EP Patent Office, EP Application No. 05758878.2, dated Oct. 24, 2011. |
| Textbook of Interventional Cardiology, 2d Ed., Chapter 75: Percutaneous Expandable Prosthetic Valves (1994). |
| Thompson et al., “Endoluminal stent grafting of the thoracic aorta: Initial experience with the Gore Excluder,” Journal of Vascular Surgery, 1163-70 (Jun. 2002). |
| Topol, “Percutaneous Expandable Prosthetic Valves.” Textbook of Interventional Cardiology, W.B. Saunders Company, 2: 1268-1276, 1994. |
| USPTO Case IPR 2017-0006, U.S. Pat. No. 8,992,608 B2, “Final Written Decision” Mar. 23, 2018. |
| USPTO Case IPR2016-_____, U.S. Pat. No. 8,992,608 “Petition for Interpartes Review of U.S. Pat. No. 8,992,608” Oct. 12, 2016. |
| USPTO Case IPR2017-01293, U.S. Pat. No. 8,992,608 B, Oct. 13, 2017. |
| Vahanian et al., “Percutaneous Approaches to Valvular Disease.” Circulation, 109: 1572-1579, Apr. 6, 2004. |
| Van Herwerden et al., “Percutaneous Valve Implantation: Back to the Future?” Euro. Heart J., 23(18): 1415-1416, Sep. 2002. |
| VentureBeatProfiles, Claudio Argento, Jan. 7, 2010, http://venturebeatprofiles.com/person/profile/claudio-argento. |
| Vossoughi et al., Stent Graft Update (2000)—Kononov, Volodos, and Parodi and Palmaz Stents; Hemobahn Stent Graft. |
| White et al., “Endoleak as a Complication of Endoluminal Grafting of Abdominal Aortic Aneurysms: Classification, Incidence, Diagnosis, and Management.” J. Endovac. Surg., 4:152-168 (1997). |
| Yoshioka et al., “Self-Expanding Endovascular Graft: An Experimental Study in Dogs.” AJR 151: 673-76 (Oct. 1988). |
| Zhou et al., “Self-expandable Valved Stent of Large Size: Off-Bypass Implantation in Pulmonary Position.” Eur. J. Cardiothorac, 24: 212-216, Aug. 2003. |
| Number | Date | Country | |
|---|---|---|---|
| 20180311036 A1 | Nov 2018 | US |
| Number | Date | Country | |
|---|---|---|---|
| 62336944 | May 2016 | US |
| Number | Date | Country | |
|---|---|---|---|
| Parent | 15466005 | Mar 2017 | US |
| Child | 16028521 | US |
