Claims
- 1. A derivative of all-trans-retinoic acid selected from the group consisting of:
- (A) esters of all-trans-retinoic acid having the following formula: ##STR7## wherein X is a member selected from the group consisting of: 2-cyclohexylethyl; 10-carbomethoxydecyl; 4-hydroxybutyl; cholesteryl; 4-bromobenzyl; ##STR8## (B) esters of all-trans-retinoic acid having the following formula: ##STR9## wherein Y is a member selected from the group consisting of: cholesteryl; phenyl; 4-bromophenyl; 4-nitrophenyl; 4-cyanophenyl; and 2,4-dichlorophenyl; and
- (C) amides of all-trans-retinoic acid having the following formula: ##STR10## wherein Z is a member selected from the group consisting of: n-propylamino; tert.-butylamino; 1,1,3,3-tetramethylbutylamino; 4-hydroxyphenylamino; 4-carbomethoxy-3-hydroxyphenylamino; .beta.-(3,4-dimethoxyphenyl)-ethylamino; 2-benzothiazolylamino; 1-imidazolyl; 1-(2-nicotinoylhydrazolyl); 1-benzotriazolyl; 1-(1,2,4-triazolyl); ##STR11##
- 2. An amide of all-trans retinoic acid according to claim 1 having the following formula: ##STR12## wherein Z is a member selected from the group consisting of: n-propylamino; tert.-butylamino; 1,1,3,3-tetramethylbutylamino; 4-hydroxyphenylamino; 4-carbomethoxy-3-hydroxyphenylamino; .beta.-(3,4-dimethoxyphenyl)-ethylamino; 2-benzothiazolylamino; 1-imidazolyl; 1-(2-nicotinoylhydrazolyl); 1-benzotriazolyl; 1-(1,2,4-triazolyl); ##STR13##
- 3. N-n-Propyl all-trans-retinamide according to claim 2.
- 4. N-Tert.-butyl all-trans-retinamide according to claim 2.
- 5. N-(1,1,3,3-Tetramethyl)-butyl all-trans-retinamide according to claim 2.
- 6. N-[.beta.-(3,4-Dimethoxyphenyl)ethyl]-all-trans-retinamide according to claim 2.
- 7. N-(4-hydroxyphenyl)-all-trans-retinamide according to claim 2.
- 8. N-(4-carbomethoxy-3-hydroxyphenyl)-all-trans retinamide according to claim 2.
Parent Case Info
This application is a division of copending application Ser. No. 628,177, filed Nov. 3, 1975, now U.S. Pat. No. 4,108,880 issued Aug. 22, 1978.
US Referenced Citations (5)
Divisions (1)
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Number |
Date |
Country |
Parent |
628177 |
Nov 1975 |
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