Claims
- 1. A compound of formula (I),
- 2. A compound according to claim 1 wherein
R1, R3 and R4 are independently selected from hydrogen or alkyl of one to six carbon atoms; X is selected from the group consisting of (1) —O—, (2) —S(O)p—, (3) —NR5SO2—, and (4) —C(O)—; and Ar1 is phenyl which is optionally substituted.
- 3. A compound according to claim 2, wherein R2 is alkyl of one to six carbon atoms.
- 4. A compound according to claim 3 selected from the group consisting of −(±)-N-[1-[[[3′-(cyanomethyl)-[1,1′-biphenyl]-4-yl]oxy]methyl]pentyl]-N-hydroxyformamide;
(±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-3-methylbutyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-methylbutyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]pentyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]ethyl]-N-hydroxyformamide; (±)-N-[2-[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]-1-methylpropyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-methoxy[1,1′-biphenyl]-4-yl)sulfonyl]methyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-chloro[1,1′-biphenyl]-4-yl)sulfonyl]methyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[[[4-(1,3-benzodioxol-5-yl)phenyl]sulfonyl]methyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[[[4-(4-chlorophenoxy)phenyl]sulfonyl]methyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-methoxy[1,1′-biphenyl]-4-yl)sulfonyl]methyl]propyl]-N-hydroxyformamide; (±)-N-[1-[1,1-dimethyl-2-[(4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]ethyl]-N-hydroxyformamide; N-[1-[4-[(4-pyridinyloxy)phenyl]sulfonyl]]ethyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[1-methyl-2-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]ethyl]formamide; and (±)-N-[1-methyl-3-(4′-chloro[1,1′-biphenyl]-4-yl)-3-oxopropyl]-N-hydroxyformamide.
- 5. A compound according to claim 2, wherein R2 is hydrogen.
- 6. A compound according to claim 5 which is
N-[2-[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]ethyl]-N-hydroxyformamide.
- 7. A compound according to claim 2, wherein R2 is selected from the group consisting of
(1) phenyl, wherein the phenyl group is unsubstituted or substituted, (2) phenoxyalkyl, wherein the alkylene group is of one to six carbon atoms, and wherein the phenyl group is unsubstituted or substituted, (3) -(alkylene)-S(O)p-phenyl, wherein the alkylene group is of one to six carbon atoms, p is zero, and the phenyl group is unsubstituted or substituted, (4) -(alkylene)-S(O)p-alkyl, (5) hydroxyalkyl, wherein the alkylene group is of one to six carbon atoms, (6) -(alkylene)-N(R5)SO2-phenyl, wherein the alkylene is of one to six carbon atoms, the phenyl group is unsubstituted or substituted, and R5 is selected from the group consisting of
(a) hydrogen and (b) alkyl of one to six carbon atoms, (7) phenylalkoxyalkyl, wherein the alkylene and alkyl groups are independently of one to six carbon atoms and the phenyl group is unsubstituted or substituted, (8) -(alkylene)-heterocycle, wherein the heterocycle is unsubstituted or substituted, (9) (heterocycle)oxyalkyl, wherein the alkylene group is of one to six carbon atoms and the heterocycle is unsubstituted or substituted, (10) -(alkylene)-phenyl, wherein the phenyl group is unsubstituted or substituted, (11) alkoxyalkyl, (12) phenylalkoxyalkyl, wherein the alkylene and alkyl groups are independently of one to six carbon atoms, (13) -(alkylene)-S(O)p-heterocycle, wherein the alkylene group is of one to six carbon atoms, and (14) heterocycle.
- 8. A compound according to claim 7 selected from the group consisting of
(±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-phenoxyethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(phenylthio)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(4-methylphenyl)ethyl]-N-hydroxyformamide; (±)-N-[2-[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]-1-(4-fluorophenyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(4-fluorophenyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(3′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-[methyl[(4-methylphenyl)sulfonyl]amino]ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-[[(2-methoxycarbonyl)phenyl]thio]ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-5-[(4-methyl-2-oxo-2H-1-benzopyran-6-yl)oxy]pentyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-4-[(4-methyl-2-oxo-2H-1-benzopyran-6-yl)oxy]butyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-4-[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]butyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-5-[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]pentyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-isopropylthioethyl]-N-hydroxyformamide; (±)-N-[1-[(phenylmethoxy)methyl]-2-[[4′-(trifluoromethyl)[1, 1′-biphenyl]-4-yl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-[1-(hydroxymethyl)-2-[[(4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-methyl[1,1′-biphenyl]-4-yl)oxy]methyl]-2-[[3-(methylsulfonyl)amino]phenyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[[[3-(diethylamino)carbonyl]phenyl]methyl]-2-[(4′-methyl[1,1′-biphenyl]-4-yl)oxy]ethyl]-N-hydroxyformamide; N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-[(4′-cyano [1,1′-biphenyl]-4-yl)oxy]ethyl]-N-hydroxyformamide; N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxyl]methyl]-2-(1,6-dihydro-3-methyl-6-oxo-1-pyridazinyl)ethyl]-N-hydroxyformamide; N-[1-[[(4′-cyano[1,1″-biphenyl]-4-yl)oxyl]methyl]-2-(1,6-dihydro-6-oxo-1-pyridazinyl)ethyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[1-(hydroxymethyl)-2-[[4-[(4-chlorophenoxy)phenyl]sulfonyl]ethyl]formamide; (±)-N-[1-[(4,4-dimethyl-2,6-dioxo-1-piperidinyl)methyl]-2-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[3-hydroxy-1-[[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]methyl]propyl]formamide; (±)-N-hydroxy-N-[1-(methoxymethyl)-2-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]ethyl]formamide; (±)-N-[1-(1,3-benzodioxol-5-yl)-2-[[4′-(trifluoromethyl)[1, 1′-biphenyl]-4-yl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[4-hydroxy-1-[[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]methyl]butyl]formamide; (±)-N-hydroxy-N-[1-[4-(methoxymethoxy)phenyl]-2-[[4′-(trifluoromethyl) [1,1′-biphenyl]-4-yl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-phenyl-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-(methoxymethyl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]formamide; (S)-N-hydroxy-N-[1-[(phenylmethoxy)methyl]-2-[[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl]oxy]ethyl]formamide; (S)-N-hydroxy-N-[1-(hydroxymethyl)-2-[[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl]oxy]ethyl]formamide; (±)-N-hydroxy-N-[1-(hydroxymethyl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]formamide; [S-(R*,R*)]-N-[(2,3-dihydroxy)-1-[[[4-[4-(trifluoromethoxy)phenoxy]phenyl]-sulfonyl]methyl]propyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[1-(hydroxymethyl)-2-[[4′-(methylsulfonyl)[1, 1′-biphenyl]-4-yl]sulfonyl]ethyl]formamide; (±)-N-[1-[[4-[(1,3-benzodioxol-5-yl)phenyl]sulfonyl]methyl]-2-hydroxyethyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[1-(hydroxymethyl)-2-[[4′-(methylthio)[1,1′-biphenyl]-4-yl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-(hydroxymethyl)-2-[[4′-(trifluoromethoxy) [1,1′-biphenyl]-4-yl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-(hydroxymethyl)-2-[(4′chloro[1,1′-biphenyl]-4-yl)sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-(hydroxymethyl)-2-[[[4-(methylsulfonyl)phenoxy]phenyl]sulfonyl]ethyl]formamide; (±)-1-[[[[4-(4-chlorophenoxy)phenyl]sulfonyl]methyl]-2-(3-methyl-6-oxo-1(6H)-pyridazinyl)ethyl]-N-hydroxyformamide; (±)-N-hydroxy]-[1-[(6-oxo-1(6H)-pyridazinyl)methyl]-2-[[4′-(trifluoromethoxy)[1.1′-biphenyl]-4-yl]oxy]ethy]formamide; (±)-N-[1-[(1,6-dihydro-3-methyl-2,6-dioxo-1 (6H)-pyrimidinyl)methyl]-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[[4-[(4-chlorophenoxy)phenyl]sulfonyl]methyl]-2-(1,6-dihydro-3-methyl-2,6-dioxo-1 (6H)-pyrimidinyl)ethyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[1-[(3-methyl-6-oxo-1(6H)-pyridazinyl)methyl]-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-(1-methyl-1H-indol-4-yl)-[2-[[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]]ethyl]formamide; (±)-N-[1-(4-chlorophenyl)-2-[[[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[2-[[[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]-1-[4-(trifluoromethyl)phenyl]ethyl]formamide; (±)-N-hydroxy-N-[1-[[(2-thienylthio)methyl]-2-[[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-[[[(4-methylphenyl)sulfonyl]methylamino]methyl]-2-[[[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[[[2-(methoxyethoxy)methyl]-1-[[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]formamide; (±)-N-[1-[(1,6-dihydro-3-methyl-2,6-dioxo-1(6H)-pyrimidinyl)methyl]-2-[[(4-phenoxyphenyl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[1-(4-hydroxyphenyl)-2-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[3-hydroxy-2-(hydroxymethyl)-1-[[[[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]methyl]propyl]formamide; (±)-N-hydroxy-N-[1-(hydroxymethyl)-2-[[[(4-chlorophenyl)thio]phenyl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-(4-morpholinylmethyl)-2-[[[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[4-hydroxy-[1-[[[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]methyl]butyl]formamide; (±)-N-[1-[(1H-isoindole-1,3(2H)-dione)methyl]-2-[[4-(4-chlorophenoxy)phenyl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[[[(4-chlorophenoxy)phenyl]sulfonyl]methyl]-4-hydroxybutyl]-N-hydroxyformamide; (±)-N-[1-[[[(4-trifluoromethoxyphenoxy)phenyl]sulfonyl]methyl]-3-hydroxypropyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[1-[(4-trifluoromethoxyphenoxy)methyl]-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-(4-trifluoromethoxyphenyl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-(2-trifluoromethylphenyl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-(4-fluorophenyl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-[[[4-[4-(trifluorophenoxy)phenyl]sulfonyl]methyl]-2-(3,4,5-trimethoxyphenyl)ethyl]formamide; (±)-N-hydroxy-N-[1-(3-pyridinyl)-2-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-(2-pyridinyl)-2-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-(1-methyl-1H-pyrrol-2-yl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-(2-thienyl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]formamide; (±)-N-[1-(2-furanyl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; [S-(R*,S*)]-N-[1-(2,2-dimethyl-1,3-dioxol-4-yl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; [S-(R*,R*)]-N-[1-(2,2-dimethyl-1,3-dioxol-4-yl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; [S-(R*,R* )]-N-[2-[(4′-chloro[1,1′-biphenyl]-4-yl)sulfonyl]-1-(2,2-dimethyl-1,3-dioxol-4-yl)ethyl]-N-hydroxyformamide; [R-(R*,R*)]-N-[1-(2,2-dimethyl-1,3-dioxol-4-yl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; [R-(S*,R*)]-N-[1-(2,2-dimethyl-1,3-dioxol-4-yl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; [S-(R*,R*)]-N-[1-(2,2-diethyl-1,3-dioxol-4-yl)-2-[[4-[4-(trifluoromethoxy)phenoxy]-phenyl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[1-(1-methyl-1H-indol-2-yl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]]ethyl]formamide; (±)-N-hydroxy-N-[1-(2,2-dimethyl-1,3-dioxan-5-yl)-2-[[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-(2-pyridinyl)-2-[[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl]sulfonyl]ethyl]formamide; [S-(R*,R*)]-N-hydroxy-N-[1-(2,2-dimethyl-1,3-dioxol-4-yl)-2-[4-[(4-phenyl-1-piperidinyl)phenyl]sulfonyl]ethyl]formamide; [S-(R*,R*,R*)]-N-[1-(2,2,5-trimethyl-1,3-dioxol-4-yl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; and (±)-N-hydroxy-N-[1-(cyclohexyl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]-sulfonyl]ethyl]formamide.
- 9. A compound according to claim 2 wherein R2 is -(alkylene)-NR6R7.
- 10. A compound according to claim 9 wherein —NR6R7 is
- 11. A compound according to claim 10 selected from the group consisting of
(±)-N-[1-[[(4′-butoxy[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[(4′-ethoxy[1,1′-biphenyl]-4-yl)oxy]ethyl]-N-hydroxyformamide; (±)-N-[1-[[4-(1,3-benzodioxol-5-yl)phenoxy]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl]oxy]ethyl]-N-hydroxyformamide; (±)-N-[1-[(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[[4′-(trifluoromethyl)[1, 1′-biphenyl]-4-yl]oxy]ethyl]-N-hydroxyfonnamide; (±)-N-[1-[[[3′-(cyanomethyl)[1,1′-biphenyl]-4-yl]oxy]methyl]-3-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)propyl]]-N-hydroxyformamide; (±)-N-[1-[[(4′-butoxy[1, 1′-biphenyl]-4-yl)sulfonyl]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-3-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)propyl]-N-hydroxyformamide; (±)-N-[1-[[[4′-(methylsulfonyll)[1,1′-biphenyl]-4-yl]oxy]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)sulfonyl]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]thio]ethyl]-N-hydroxyformamide; (±)-N-[1-[(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[[[4-(4-chlorophenoxy)phenyl]sulfonyl]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyfornamide; (±)-N-[1-[[(4′-butyl[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[[3 ′-(cyanomethyl)[1,1′-biphenyl]-4-yl]oxy]methyl]-2-(4,4-dimethyl-2,5-dioxo-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[[4′-(2-methoxyethoxy)[1,1′-biphenyl]-4-yl]oxy]ethyl]-N-hydroxyformamide; (±)-N-[1-[(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[(4′-propoxy[1,1′-biphenyl]-4-yl)oxy]ethyl]-N-hydroxyformamide; N-[1-[(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[(4′-pentyloxy[1, 1′-biphenyl]-4-yl)oxy]ethyl]-N-hydroxyformamide; (±)-N-[1-[[[3′-(cyanomethyl)[1,1′-biphenyl]-4-yl]sulfonyl]methyl]-3-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)propyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)sulfonyl]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[[4-(4-fluorophenoxy)phenyl]sulfonyl]methyl]-2-(4,4-dimethyl -2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (S)-N-[1-[(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[[4′-(trifluoromethoxy)[1, 1′-biphenyl]-4-yl]oxy]ethyl]-N-hydroxyformamide; (R)-N-[1-[(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl]oxy]ethyl]-N-hydroxyformamide; N-[1-[[[4′-(trifluoromethoxy))[1,1′-biphenyl]-4-yl]oxy]methyl]-3-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)propyl]-N-hydroxyformamide; N-[1-[4-[(4-pyridinylthio)phenoxy]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; N-[1-[[[(4-chlorophenoxy)phenyl]sulfonyl]methyl]-3-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)propyl]-N-hydroxyformamide; N-[1-[[[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl]sulfonyl]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; N-[1-[[[(4-cyanophenoxy)phenyl]sulfonyl]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; N-[1-[[4-[[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]methyl]-3-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)propyl]-N-hydroxyformamide; (±)-N-[3-[(2,5-dioxo-3,4,4-trimethyl-1-imidazolidinyl)-1-[[4-[4-(trifluoromethyl)phenoxy]phenyl]sulfonyl]methyl]propyl]-N-hydroxyformamide; (±)-N-[1-[(2,5-dioxo-3,4,4-trimethyl-1-imidazolidinyl)methyl]-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; and (±)-N-[1-[(2,5-dioxo-4,4-dimethyl-1-imidazolidinyl)methyl]-2-methyl-2-[[4′-(trifluoromethoxy) [1,1′-biphenyl]-4-yl]oxy]propyl]-N-hydroxyformamide.
- 12. A compound according to claim 9 selected from the group consisting of
(±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(2,3-dihydro-1,3-dioxo-1 H-isoindol-2-yl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-3-(3,4,4-trimethyl-2,5-dioxoimidazolidiny-1-yl)propyl]-N-hydroxyformamide; (±)-N-[1-[4-[(2-E-phenylethenyl)phenoxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[4-(2-furanyl)phenoxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-butoxy[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyfornamide; (±)-N-[1-[[(4′-fluoro[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[[4′-(trifluoro methyl) [1,1′-biphenyl]-4-yl]oxy]ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-methoxy[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-methyl[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-butoxy[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3-methy-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[4-(3-thienyl)phenoxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[([1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-midazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(3′-chloro-4′-fluoro[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(2′-methyl[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethy-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyanol[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyanol[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[4-(4-phenyl-1-piperidinyl)phenoxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-[4,4-dimethyl-2,5-dioxo-3-(3-pyridinylmethyl)-1-imidazolidinyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[[(3′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[[4′-(methylthio)[1,1′-biphenyl]-4-yl]oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[4-[[4-(trifluoromethyl)phenoxy]phenoxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl]oxy]methyl]-2-(3,4,4-trimethy-2,5-dioxo-1-imidazolidinyl)ethyl]-2-N-hydroxyformamide; (±)-N-[1-[[[4′-(methylsulfonyl)[1,1′-biphenyl]-4-yl]oxy]methyl]-2-(3,4,4-trimethy-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[[3′-(cyanomethyll)-4′-methoxyl[1,1′-biphenyl]-4-yl]oxy]methyl]-2-(3,4,4-trimethy-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(3′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(2,5-dioxo-1-pyrrolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(4,4-dimethyl-2,6-dioxo-1-piperidinyl)ethyl]-N-hydroxyfonnamide;
N-[S-[[(4′-cyano [1,1′-biphenyl]-4-yl)oxy]methyl]-2-(2,5-dioxo-1-pyrrolidinyl)ethyl]-N-hydroxyformamide; N-[1R-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(2,5-dioxo-1-pyrrolidinyl)ethyl]-N-hydroxyformamide, (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3-ethyl-3-methyl-2,5-dioxo-1-pyrrolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(5,5-dimethyl-2,4-dioxo-3-oxazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)sulfonyl]methyl]-2-(3,4,4-trimethy-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3-methyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-chloro-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(3 ′-cyanomethyl-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,5,5-trimethyl-2,4-dioxo-1-imidazolidinyl)propyl]-N-hydroxyformamide; (±)-N-[1-[[(3′-cyanomethyl-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3-ethyl-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3-benzyl-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide, (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-y)oxy]methyl]-2-(3,5,5-trimethyl-2,4-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[(2,5-dioxo-1-imidazolidinyl)methyl]-2-[[4′-(trifluoromethoxy)[,1′-biphenyl]-4-yl]oxy]ethyl]-N-hydroxyformamide; (±)-N-[1-[[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-butyl[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3-methy-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[(3-methy-2,5-dioxo-1-imidazolidinyl)methyl]-2-[[4′-(trifluoromethoxy) [1,1′-biphenyl]-4-yl]oxy]ethyl]-N-hydroxyformamide; (±)-N-[1-[[[4-(4-chlorophenoxy)phenyl]sulfonyl]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4-butyl[1,1′-biphenyl]-4-yl)sulfonyl]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[4-(2-thienyl)phenoxy]methyl]-2-[1-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(3-nitro[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl]sulfonyl]methyl]-2-(3,4,4-trimethy-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)sulfonyl]methyl]-2-(3-methy-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[[3′-(cyanomethyl)[1,1′-biphenyl]-4-yl]sulfonyl]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[4-(4-pyridinyl)phenoxy]methyl]-2-(3,4,4-trimethy-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; N-[1-[[[4′-(aminosulfonyl)[1,1′-biphenyl]-4-yl]oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; N-[1-[[4-[[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-(5,5-dimethyl-2,4-dioxo-3-oxazolidinyl)-2-[[4′-(trifluoromethoxy)[1, 1′-biphenyl]-4-yl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[(dimethylamino)methyl]-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]-sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[(1, 1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)methyl]-2-[[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl]oxy]ethyl]-N-hydroxyformamide; (±)-N-[1-[(2,5-dioxo-3,4,4-trimethyl-1-imidazolidinyl)methyl]-2-[[4-[4-(trifluoromethyl)phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[(2,5-dioxo-3,4,4-trimethyl-1-imidazolidinyl)methyl]-2-[[4-(4-butylphenoxy)phenyl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[[4-[(4-chlorophenoxy)phenyl]sulfonyl]methyl]-3-[(2,5-dioxo-3,4,4-trimethyl-1-imidazolidinyl)methyl]propyl]-N-hydroxyformamide; (±)-N-[1-[(2,5-dioxo-3,4,4-trimethyl-1-imidazolidinyl)methyl]-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[(2,5-dioxo-3,4,4-trimethyl-1-imidazolidinyl)methyl]-2-[[4-(4-cyanophenoxy)phenyl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[(2,5-dioxo-3,4,4-trimethyl-1-imidazolidinyl)methyl]-2-[[4-(4-bromophenoxy)phenyl]sulfonyl]ethyl]-N-hydroxyformamide; and (−)-(S)-N-[1-[[[4-(4-chlorophenoxy)phenyl]sulfonyl]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide.
- 13. A compound according to claim 1, wherein R1 and R2, taken together with the carbon atom to which they are attached form a ring selected from
(1) spiroalkyl of three to eight carbon atoms and (2) tetrahydropyranyl.
- 14. A compound according to claim 13 selected from the group consisting of
N-[4-[4-[[(4-chlorophenoxy)phenyl]sulfonyl]methyl]tetrahydro-2H-pyran-4-yl]-N-hydroxyformamide and N-[4-[4-[(4′-chloro[1,1′-biphenyl]-4-yl)sulfonyl]methyl]tetrahydro-2H-pyran-4-yl]-N-hydroxyformamide.
- 15. A compound according to claim 1 wherein
R1 and R3 taken together with the carbon atoms to which they are attached form a 5, 6, or 7-membered carbocyclic ring.
- 16. A compound according to claim 15 selected from the group consisting of
(±)-N-[2-[4-(4′-cyano [1,1′-biphenyl]-4-yl)oxy]cyclohexyl]-N-hydroxyforimamide and (±)-N-[2-[4-[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl)oxy]cyclohexyl]-N-hydroxy-formamide.
- 17. A compound selected from the group consisting of
(±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-phenoxyethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(phenylthio)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(2,3-dihydro-1,3-dioxo-1 H-isoindol-2-yl)ethyl]-N-hydroxyfonnamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-3-(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)propyl]-N-hydroxyformamide; (±)-N-[1-[[[3′-(cyanomethyl)-[1,1′-biphenyl]-4-yl]oxy]methyl]pentyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-3-methylbutyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-methylbutyl]-N-hydroxyfonnamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]pentyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(4-methylphenyl)ethyl]-N-hydroxyformamide; (±)-N-[2-[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]-1-(4-fluorophenyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(4-fluorophenyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]ethyl]-N-hydroxyformamide; (±)-N-[2-[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]ethyl]-N-hydroxyformamide; (±)-N-[1-[4-[(2E-phenylethenyl)phenoxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[4-(2-fuiranyl)phenoxy]methyl]-2-(3,4,4-trimethyl-2, 5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-butoxy[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-fluoro[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[[4′-(trifluoromethyl)[1, 1′-biphenyl]-4-yl]oxy]ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-methoxy[l1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-methyll[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-butoxy[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[(4 ′-ethoxy [1,1′-biphenyl]-4-yl)oxy]ethyl]-N-hydroxyformamide; (±)-N-[1-[[4-(1,3-benzodioxol-5-yl)phenoxy]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyfornamide; (±)-N-[1-[[(4′-butoxyl[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3-methy-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[4-(3-thienyl)phenoxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyfornamide; (±)-N-[1-[[([1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(3′-chloro-4′-fluoro[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(2′-methyl[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethy-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyanol [,1′-biphenyl]-4-yl)oxy]methyl]-2-(2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyanol[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)ethyl]-N-hydroxyformamide; (±)-N-[1-[(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[[4′-(trifluoromethoxy) [1,1′-biphenyl]-4-yl]oxy]ethyl]-N-hydroxyformamide; (±)-N-[1-[[4-(4-phenyl-1-piperidinyl)phenoxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]oxy]ethyl]-N-hydroxyformamide; (±)-N-[1-[[(3′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-[methyl[(4-methylphenyl)sulfonyl]amino]ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-[4,4-dimethyl-2,5-dioxo-3-(3-pyridinylmethyl)-1-imidazolidinyl]ethyl]-N-hydroxyformnamide; (±)-N-[2-[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]-1-methylpropyl]-N-hydroxyformamide; (±)-N-[1-[[(3′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[[4′-(methylthio)[1,1′-biphenyl]-4-yl]oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[4-[[4-(trifluoromethyl)phenoxy]phenoxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[[4′-(trifluoromethoxy) [1,1′-biphenyl]-4-yl]oxy]methyl]-2-(3,4,4-trimethy-2,5-dioxo-1-imidazolidinyl)ethyl]-2-N-hydroxyformamide; (±)-N-[1-[[[4′-(methylsulfonyl)[1,1′-biphenyl]-4-yl]oxy]methyl]-2-(3,4,4-trimethy-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[[3′-(cyanomethyll)-4′-methoxyl[1,1′-biphenyl]-4-yl]oxy]methyl]-2-(3,4,4-trimethy-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[[3′-(cyanomethyl)[1,1′-biphenyl]-4-yl]oxy]methyl]-3-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)propyl]]-N-hydroxyformamide; (±)-N-[1-[[(4′-butoxy[1,1′-biphenyl]-4-yl)sulfonyl]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-3-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)propyl]-N-hydroxyformamide; (±)-N-[1-[[[4′-(methylsulfonyll)[1,1′-biphenyl]-4-yl]oxy]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(3′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(2,5-dioxo-1-pyrrolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(4,4-dimethyl-2,6-dioxo-1-piperidinyl)ethyl]-N-hydroxyformamide; (±)-N-[iS-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(2,5-dioxo-1-pyrrolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1 R-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(2,5-dioxo-1-pyrrolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3-ethyl-3-methyl-2,5-dioxo-1-pyrrolidinyl)ethyl]-N-hydroxyformamide; N-[4-[4-[[(4-chlorophenoxy)phenyl]sulfonyl]methyl]tetrahydro-2H-pyran-4-yl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-[[(2-methoxycarbonyl)phenyl]thio]ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-5-[(4-methyl-2-oxo-2H-1-benzopyran-6-yl)oxy]pentyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-4-[(4-methyl-2-oxo-2H-1-benzopyran-6-yl)oxy]butyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-4-[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]butyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-5-[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]pentyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(5,5-dimethyl-2,4-dioxo-3-oxazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)sulfonyl]methyl]-2-(3,4,4-trimethy-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3-methyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)sulfonyl]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-chloro-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(3′-cyanomethyl-[1,1′-biphenyl]-4-y)oxy]methyl]-2-(3,5,5-trimethyl-2,4-dioxo-1-imidazolidinyl)propyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-y)oxy]methyl]-2-isopropylthioethyl]-N-hydroxyformamide; (±)-N-[1-[[(3′-cyanomethyl-[1,1′-biphenyl]-4-y)oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3-ethyl-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3-benzyl-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano-[1,1′-biphenyl]-4-y)oxy]methyl]-2-(3,5,5-trimethyl-2,4-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[4′-methoxyl[1,1′-biphenyl]-4-yl)sulfonyl]methyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-chloro[1,1′-biphenyl]-4-yl)sulfonyl]methyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[[[4-(1,3-benzodioxol-5-yl)phenyl]sulfonyl]methyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[[[4-(4-chlorophenoxy)phenyl]sulfonyl]methyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-methoxy[1,1′-biphenyl]-4-yl)sulfonyl]methyl]propyl]-N-hydroxyformamide; (±)-N-[1-[1,1-dimethyl-2-[(4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[(phenylmethoxy)methyl]-2-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-[1-(hydroxymethyl)-2-[[(4′-(trifluoromethyl) [1,1′-biphenyl]-4-yl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]thio]ethyl]-N-hydroxyformamide; (±)-N-[1-[(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[(2,5-dioxo-1-imidazolidinyl)methyl]-2-[[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl]oxy]ethyl]-N-hydroxyformamide; (±)-N-[1-[[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-butyl[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3-methy-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[(3-methy-2,5-dioxo-1-imidazolidinyl)methyl]-2-[[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl]oxy]ethyl]-N-hydroxyformamide; N-[4-[4-[(4′-chloro[1,1′-biphenyl]-4-yl)sulfonyl]methyl]tetrahydro-2H-pyran-4-yl]-N-hydroxyformamide; (±)-N-[1-[[[4-(4-chlorophenoxy)phenyl]sulfonyl]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[[4-(4-chlorophenoxy)phenyl]sulfonyl]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4-butyl[1,1′-biphenyl]-4-yl)sulfonyl]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-butyl[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[[3′-(cyanomethyl)[1,1′-biphenyl]-4-yl]oxy]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[4-(2-thienyl)phenoxy]methyl]-2-[1-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(3-nitro[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-methyl[1,1′-biphenyl]-4-yl)oxy]methyl]-2-[[3-(methylsulfonyl)amino]phenyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[[[3-(diethylamino)carbonyl]phenyl]methyl]-2-[(4′-methyl[1,1′-biphenyl]-4-yl)oxy]ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-[(4′-cyano [1,1′-biphenyl]-4-yl)oxy]ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)oxy]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[[4′-(2-methoxyethoxy)[1,1′-biphenyl]-4-yl]oxy]ethyl]-N-hydroxyformamide; (±)-N-[1-[(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[(4′-propoxy[1,1′-biphenyl]-4-yl)oxy]ethyl]-N-hydroxyformamide; (±)-N-[1-[(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[(4′-pentyloxy[l1,1′-biphenyl]-4-yl)oxy]ethyl]-N-hydroxyformamide; (±)-N-[1-[[[3′-(cyanomethyl)[1,1′-biphenyl]-4-yl]sulfonyl]methyl]-3-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)propyl]-N-hydroxyformamide; (±)-N-[1-[[[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl]sulfonyl]methyl]-2-(3,4,4-trimethy-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)sulfonyl]methyl]-2-(3-methy-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[[3′-(cyanomethyl)[1,1′-biphenyl]-4-yl]sulfonyl]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1″-biphenyl]-4-yl)oxyl]methyl]-2-(1,6-dihydro-3-methyl-6-oxo-1-pyridazinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[(4′-cyano[1,1′-biphenyl]-4-yl)sulfonyl]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[[4-(4-fluorophenoxy)phenyl]sulfonyl]methyl]-2-(4,4-dimethyl -2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[[4-(4-pyridinyl)phenoxy]methyl]-2-(3,4,4-trimethy-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (S)-N-[1-[(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl]oxy]ethyl]-N-hydroxyformamide; (R)-N-[1-[(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl]oxy]ethyl]-N-hydroxyformamide; N-[1-[[[4′-(trifluoromethoxy))[1,1′-biphenyl]-4-yl]oxy]methyl]-3-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)propyl]-N-hydroxyformamide; N-[1-[4-[(4-pyridinylthio)phenoxy]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; N-[1-[[[(4-chlorophenoxy)phenyl]sulfonyl]methyl]-3-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)propyl]-N-hydroxyformamide; N-[1-[[(4′-cyano[1,1″-biphenyl]-4-yl)oxyl]methyl]-2-(1,6-dihydro-6-oxo-1-pyridazinyl)ethyl]-N-hydroxyformamide; N-[1-[[[4′-(aminosulfonyl)[1,1′-biphenyl]-4-yl]oxy]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; N-[1-[[[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl]sulfonyl]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformnamide; N-[1-[4-[(4-pyridinyloxy)phenyl]sulfonyl]]ethyl]-N-hydroxyformamide; N-[1-[[[(4-cyanophenoxy)phenyl]sulfonyl]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; N-[1-[[4-[[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]methyl]-3-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)propyl]-N-hydroxyformamide; N-[1-[[4-[[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]methyl]-2-(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[1-(3-pyridinyl)-2-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]-sulfonyl]ethyl]formamide;(±)-N-hydroxy-N-[1-(hydroxymethyl)-2-[[4-[(4-chlorophenoxy)phenyl]sulfonyl]-ethyl]formamide; (±)-N-hydroxy-N-[1-methyl-2-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]-ethyl]formamide; (±)-N-hydroxy-N-[1-(2-pyridinyl)-2-[[4′-(trifluoromethyl) [1,1′-biphenyl]-4-yl]-sulfonyl]ethyl]formamide; (±)-N-[1-[(4,4-dimethyl-2,6-dioxo-1-piperidinyl)methyl]-2-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[3-hydroxy-1-[[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]-methyl]propyl]formamide; (±)-N-hydroxy-N-[1-(methoxymethyl)-2-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]ethyl]formamide; (±)-N-[1-(1,3-benzodioxol-5-yl)-2-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]-ethyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[4-hydroxy-1-[[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]-methyl]butyl]formamide; (±)-N-hydroxy-N-[1-[4-(methoxymethoxy)phenyl]-2-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-(1-methyl-1H-pyrrol-2-yl)-2-[[4-[4-(trifluoromethoxy)phenoxy]-phenyl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-phenyl-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]-ethyl]formamide; (±)-N-hydroxy-N-[1-(2-thienyl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]-ethyl]formamide; (±)-N-[1-(2-furanyl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-[1-(5,5-dimethyl-2,4-dioxo-3-oxazolidinyl)-2-[[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[1-(methoxymethyl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]-sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-[(phenylmethoxy)methyl]-2-[[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl]oxy]ethyl]formamide; (±)-N-hydroxy-N-[1-(hydroxymethyl)-2-[[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl]oxy]ethyl]formamide; (±)-N-hydroxy-N-[1-(hydroxymethyl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]-sulfonyl]ethyl]formamide; [S-(R*,S*)]-N-[1-(2,2-dimethyl-1,3-dioxol-4-yl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; [S-(R*,R*)]-N-[1-(2,2-dimethyl-1,3-dioxol-4-yl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; [S-(R* ,R*)]-N-hydroxy-N-[(2,3-dihydroxy)-1-[[[4-[4-(trifluoromethoxy)phenoxy]phenyl]-sulfonyl]methyl]propyl]-N-hydroxyformamide; (±)-N-[1-[(dimethylamino)methyl]-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]-sulfonyl]ethyl]-N-hydroxyformamide; [S-(R*,R*)]-N-[2-[(4′-chloro[1,1′-biphenyl]-4-yl)sulfonyl]-1-(2,2-dimethyl-1,3-dioxol-4-yl)ethyl]-N-hydroxyformamide; (±)-N-[1-[(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)methyl]-2-[[4′-(trifluoromethoxy) [1,1′-biphenyl]-4-yl]oxy]ethyl]-N-hydroxyformamide; [R-(R*,R*)]-N-[1-(2,2-dimethyl-1,3-dioxol-4-yl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; [R-(S*,R*)]-AN[1-(2,2-dimethyl-1,3-dioxol-4-yl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; [S-(R*,R*)]-N-[1-(2,2-diethyl-1,3-dioxol-4-yl)-2-[[4-[4-(trifluoromethoxy)phenoxy]-phenyl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[1-(hydroxymethyl)-2-[[4′-(methylsulfonyl) [1,1′-biphenyl]-4-yl]sulfonyl]ethyl]formamide; (±)-N-[1-[[4-[(1,3-benzodioxol-5-yl)phenyl]sulfonyl]methyl]-2-hydroxyethyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[1-(hydroxymethyl)-2-[[4′-(methylthio)[1,1′-biphenyl]-4-yl]-sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-(hydroxymethyl)-2-[[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-(hydroxymethyl)-2-[(4′chloro [1,1′-biphenyl]-4-yl)sulfonyl]-ethyl]formamide; (±)-N-[1-[(2,5-dioxo-3,4,4-trimethyl-1-imidazolidinyl)methyl]-2-[[4-[4-(trifluoromethyl)phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[1-(hydroxymethyl)-2-[[[4-(methylsulfonyl)phenoxy]phenyl]-sulfonyl]ethyl]formamide; (±)-N-[1-methyl-3-(4′-chloro[1,1′-biphenyl]-4-yl)-3-oxopropyl]-N-hydroxyformamide; (±)-N-[1-[(2,5-dioxo-3,4,4-trimethyl-1-imidazolidinyl)methyl]-2-[[4-(4-butylphenoxy)-phenyl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-[3-[(2,5-dioxo-3,4,4-trimethyl-1-imidazolidinyl)-1-[[4-[4-(trifluoromethyl)phenoxy]phenyl]sulfonyl]methyl]propyl]-N-hydroxyformamide; (±)-N-[1-[(2,5-dioxo-3,4,4-trimethyl-1-imidazolidinyl)methyl]-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[[4-[(4-chlorophenoxy)phenyl]sulfonyl]methyl]-3-[(2,5-dioxo-3,4,4-trimethyl-1-imidazolidinyl)methyl]propyl]-N-hydroxyformamide; (±)-N-[2-[4-(4′-cyano[1,1′-biphenyl]-4-yl)oxy]cyclohexyl]-N-hydroxyformamide; (±)-N-[2-[4-[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl)oxy]cyclohexyl]-N-hydroxyformamide; (±)-1-[[[[4-(4-chlorophenoxy)phenyl]sulfonyl]methyl]-2-(3-methyl-6-oxo-1 (6H)-pyridazinyl)ethyl]-N-hydroxyformamide; (±)-N-hydroxy]-[1-[(6-oxo-1(6H)-pyridazinyl)methyl]-2-[[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl]oxy]ethy]formamide; (±)-N-[1-[(1,6-dihydro-3-methyl-2,6-dioxo-1(6H)-pyrimidinyl)methyl]-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[(1,6-dihydro-3-methyl-2,6-dioxo-1 (6H)-pyrimidinyl)methyl]-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[(2,5-dioxo-3,4,4-trimethyl-1-imidazolidinyl)methyl]-2-methyl-2-[[4′-(trifluoromethoxy) [1,1′-biphenyl]-4-yl]oxy]propyl]-N-hydroxyformamide; (±)-N-[1-[[4-[(4-chlorophenoxy)phenyl]sulfonyl]methyl]-2-(1,6-dihydro-3-methyl-2,6-dioxo-1 (6H)-pyrimidinyl)ethyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[1-[(3-methyl-6-oxo-1(6H)-pyridazinyl)methyl]-2-[[4-[4-(trifluoro-methoxy)phenoxy]phenyl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-(1-methyl-1H-indol-4-yl)-[2-[[4-(trifluoromethoxy)phenoxy]-phenyl]sulfonyl]]ethyl]formamide; (±)-N-hydroxy-N-[1-(1-methyl-1H-indol-2-yl)-2-[[4-[4-(trifluoromethoxy)phenoxy]-phenyl]sulfonyl]]ethyl]formamide; (±)-N-[1-(4-chlorophenyl)-2-[[[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[2-[[[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]-1-[4-(trifluoro-methyl)phenyl]ethyl]formamide; (±)-N-[1-[(2,5-dioxo-3,4,4-trimethyl-1-imidazolidinyl)methyl]-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[1-[[(2-thienylthio)methyl]-2-[[4-(trifluoromethoxy)phenoxy]-phenyl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-[[[(4-methylphenyl)sulfonyl]methylamino]methyl]-2-[[[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[[[2-(methoxyethoxy)methyl]-1-[[4-(trifluoromethoxy)phenoxy]-phenyl]sulfonyl]ethyl]formamide; (±)-N-[1-[(1,6-dihydro-3-methyl-2,6-dioxo-1(6H)-pyrimidinyl)methyl]-2-[[(4-phenoxyphenyl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[1-(4-hydroxyphenyl)-2-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-(2,2-dimethyl-1,3-dioxan-5-yl)-2-[[4-(trifluoromethoxy)phenoxy]-phenyl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[3-hydroxy-2-(hydroxymethyl)-1-[[[[4-(trifluoromethoxy)phenoxy]-phenyl]sulfonyl]methyl]propyl]formamide; (±)-N-hydroxy-N-[1-(hydroxymethyl)-2-[[[(4-chlorophenyl)thio]phenyl]sulfonyl]-ethyl]formamide; (±)-N-hydroxy-N-[1-(4-morpholinylmethyl)-2-[[[4-(trifluoromethoxy)phenoxy]-phenyl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[4-hydroxy-[1-[[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]-butyl]formamide; (±)-N-[1-[(1H-isoindole-1,3(2H)-dione)methyl]-2-[[4-(4-chlorophenoxy)phenyl]-sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-[1-[(2,5-dioxo-3,4,4-trimethyl-1-imidazolidinyl)methyl]-2-[[4-(4-cyanophenoxy)phenyl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[1-(2-pyridinyl)-2-[[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl]sulfonyl]ethyl]formamide; (±)-N-[1-[[[(4-chlorophenoxy)phenyl]sulfonyl]methyl]-4-hydroxybutyl]-N-hydroxy-formamide; (±)-N-[1-[[[(4-trifluoromethoxyphenoxy)phenyl]sulfonyl]methyl]-3-hydroxypropyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[1-[(4-trifluoromethoxyphenoxy)methyl]-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]ethyl]formamide; [S-(R*,R*)]-N-hydroxy-N-[1-(2,2-dimethyl-1,3-dioxol-4-yl)-2-[4-[(4-phenyl-1-piperidinyl)phenyl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-(4-trifluoromethoxyphenyl)-2-[[4-[4-(trifluoromethoxy)phenoxy]-phenyl]sulfonyl]ethyl]formamide; [S-(R*,R*,R*)]-N-[1-(2,2,5-trimethyl-1,3-dioxol-4-yl)-2-[[4-[4-(trifluoromethoxy)-phenoxy]phenyl]sulfonyl]ethyl]-N-hydroxyformamide; (±)-N-hydroxy-N-[1-(2-trifluoromethylphenyl)-2-[[4-[4-(trifluoromethoxy)phenoxy]-phenyl]sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-(4-fluorophenyl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]-sulfonyl]ethyl]formamide; (±)-N-hydroxy-N-[1-(cyclohexyl)-2-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]-sulfonyl]ethyl]formamide; (−)-(S)-N-[1-[[[4-(4-chlorophenoxy)phenyl]sulfonyl]methyl]-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-N-hydroxyformamide; (±)-N-[1-[(2,5-dioxo-3,4,4-trimethyl-1-imidazolidinyl)methyl]-2-[[4-(4-bromophenoxy)phenyl]sulfonyl]ethyl]-N-hydroxyformamide; and (±)-N-hydroxy-N-[1-[[[4-[4-(trifluorophenoxy)phenyl]sulfonyl]methyl]-2-(3,4,5-trimethoxyphenyl)ethyl]formamide.
- 18. A compound according to claim 17 which is
(S)-N-[1-[(4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-2-[[4′-(trifluoromethoxy) [1,1′-biphenyl]-4-yl]oxy]ethyl]-N-hydroxyformamide.
- 19. A method for inhibiting matrix metalloproteinases in a mammal in need of such treatment, comprising administering to the mammal a therapeutically effective amount of a compound of claim 1.
- 20. A composition for inhibiting matrix metalloproteinases comprising a pharmaceutical carrier and a therapeutically effective amount of a compound of claim 1.
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application is a continuation-in-part of U.S. patent application Ser. No. 09/129,360, filed Aug. 5, 1998, pending.
Continuations (1)
|
Number |
Date |
Country |
Parent |
09239087 |
Jan 1999 |
US |
Child |
09905242 |
Jul 2001 |
US |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
09129360 |
Aug 1998 |
US |
Child |
09239087 |
Jan 1999 |
US |