Claims
- 1. A compound of formulae I-VI
- 2. A compound of claim 1, of formula I
- 3. A compound of claim 1, of formula II
- 4. A compound of claim 1, of formula III
- 5. A compound of claim 1, of formula IV
- 6. A compound of claim 1, of formula V
- 7. A compound of claim 1, of formula VI
- 8. A method of treating an indication mediated by Rho-kinase, comprising administering to a host in a need thereof a compound of claim 1.
- 9. A method of treating hypertension, atherosclerosis, restenosis, cerebral ischemia, cerebral vasospasm, neuronal degeneration, spinal cord injury, cancer of the breast, colon, prostate, ovaries, brain or lung, thrombotic disorders, asthma, glaucoma, osteoporosis or erectile dysfunction, comprising administering to a host in need thereof a compound according to claim 1.
- 10. A method according to claim 8, wherein the host is a human.
- 11. A method according to claim 9, wherein the host is a human.
- 12. A method for the preparation of a compound as to claim 1, comprising (a) reacting compound of formula 1 with a compound of formula 2, in the presence of a base, to produce a compound of formula 3
Parent Case Info
[0001] This application claims the benefit of the filing date of U.S. Provisional Application Serial No. 60/277,974, filed Mar. 23, 2001 and U.S. Provisional Application Serial No.: 60/315,338, filed Aug. 29, 2001.
Provisional Applications (2)
|
Number |
Date |
Country |
|
60277974 |
Mar 2001 |
US |
|
60315338 |
Aug 2001 |
US |