Ribosome Heterogeneity as a Mechanism for Metabolic Regulation

Information

  • Research Project
  • 10242772
  • ApplicationId
    10242772
  • Core Project Number
    DP1DK119141
  • Full Project Number
    5DP1DK119141-04
  • Serial Number
    119141
  • FOA Number
    RFA-DK-17-011
  • Sub Project Id
  • Project Start Date
    9/1/2018 - 5 years ago
  • Project End Date
    8/31/2023 - 9 months ago
  • Program Officer Name
    LAUGHLIN, MAREN R
  • Budget Start Date
    9/1/2021 - 2 years ago
  • Budget End Date
    8/31/2022 - a year ago
  • Fiscal Year
    2021
  • Support Year
    04
  • Suffix
  • Award Notice Date
    8/13/2021 - 2 years ago

Ribosome Heterogeneity as a Mechanism for Metabolic Regulation

PROJECT SUMMARY/ABSTRACT The current epidemic of obesity and metabolic syndrome has been linked to alterations in diet and lifestyle. Although human tissues demonstrate remarkable metabolic plasticity in response to physical activity and dietary exposures, our understanding of the mechanisms that underlie the beneficial or deleterious effects of exercise or nutrient exposures on skeletal muscle and hepatic metabolism are incomplete. The goal of this study is to uncover new mechanisms that underlie enhanced skeletal muscle insulin sensitivity following an acute bout of exercise and changes in hepatic glucose homeostasis and insulin sensitivity in refeeding responses and time-restricted feeding paradigms. I will test the radically novel hypothesis that remodeling of ribosomes in these tissues rapidly generates changes in the proteome and serves as a mechanism for metabolic plasticity. This work will advance our understanding of how environmental cues shape metabolic physiology and has the potential to identify new targets for preventive therapies aimed at improving human metabolic fitness.

IC Name
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
  • Activity
    DP1
  • Administering IC
    DK
  • Application Type
    5
  • Direct Cost Amount
    481898
  • Indirect Cost Amount
    332510
  • Total Cost
    814408
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    847
  • Ed Inst. Type
  • Funding ICs
    NIDDK:814408\
  • Funding Mechanism
    Non-SBIR/STTR RPGs
  • Study Section
    ZDK1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    JOSLIN DIABETES CENTER
  • Organization Department
  • Organization DUNS
    071723084
  • Organization City
    BOSTON
  • Organization State
    MA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    022155306
  • Organization District
    UNITED STATES