RIMI: Regulation of Neuronal Differentiation by the Polyamines

Information

• NSF Award
• 9550699

Owner

• MEHARRY MEDICAL COLLEGE

• Award Id

  9550699

• Award Effective Date

  9/1/1995 - 29 years ago

• Award Expiration Date

  8/31/1998 - 26 years ago

• Award Amount

  $ 250,001.00

• Award Instrument

  Standard Grant

9550699 Maleque Meharry Medical College seeks funding for research that would investigate the influences of the ODC/polyamine system on the process of neuronal differentiation by examining the interactions between the ODC/polyamine system and GAP-43. Furthermore, the signal transduction pathways that may modulate these crucial elements of neuronal differentiation will also be investigated. The three specific aims of this work are: (1) Determine the developmental profiles of ODC, GAP-43 (activity, protein and m-RNA) and the polyamine in the postnatal cerebellum and neo-cortex; (2) compare the relationship between the ODC/polyamine system and GAP- 43 and to test their interdependence through inhibition of ODC activity by DFMO; (3) study common signal transduction mechanisms that may modulate both the ODC/polyamine system and GAP-43. This would be accomplished through examination of PKC activity and the expression of isoforms and PI turnover. Three graduate students will participate in the proposed work. ***

• Program Officer

  William A. Sibley

• Min Amd Letter Date

  6/7/1995 - 29 years ago

• Max Amd Letter Date

  6/7/1995 - 29 years ago

• ARRA Amount

• Name

  Meharry Medical College

• City

  Nashville

• State

  TN

• Country

  United States

• Address

  1005 D. B. Todd Blvd

• Postal Code

  372083501

• Phone Number

  6153276703

• First Name

  Emmanuel

• Last Name

  Onaivi

• Email Address

  OnaiviE@wpunj.edu

• Start Date

  6/7/1995 12:00:00 AM

• First Name

  Mohammed

• Last Name

  Maleque

• Start Date

  6/7/1995 12:00:00 AM

• First Name

  Nasser

• Last Name

  Zawia

• Start Date

  6/7/1995 12:00:00 AM

• Name

  Health

• Code

  203000

• Name

  Life Science Biological

• Code

  61

• Text

  RES IMPROVE IN MINORITY INSTIT

• Code

  9130

• Text

  DEVELOPMENTAL NEUROSCIENCE

• Code

  1190

• Text

  GRADUATE INVOLVEMENT

• Code

  9179

• Text

  SCIENCE, MATH, ENG & TECH EDUCATION