Claims
- 1. A compound of the formula ##STR7## wherein R.sup.1 is a hydrogen atom, hydroxy or alkyl; R.sup.2 is ##STR8## R.sup.3 is a hydrogen atom, alkyl or hydroxyalkyl; R.sup.4 is a hydrogen atom, alkyl or phenyl; R.sup.5 is an oxygen atom, two hydrogen atoms, or a hydrogen atom and one of alkyl, phenyl, halogen atom, or hydroxy; R.sup.6 and R.sup.7, which can be alike or different, each are a hydrogen atom, a halogen atom, hydroxy, amino, nitro, cyano, alkyl, alkoxy, alkanoyloxy, monoalkylamino, dialkylamino, alkanoylamino, or benzoyloxy; R.sup.8 is a hydrogen atom or alkyl; R.sup.9 is cycloalkyl or cycloalkenyl of 5 to 7 carbon atoms which is unsubstituted or mono- or disubstituted by R.sup.10 and is interrupted in the ring by an oxygen atom, a sulfur atom, SO or SO.sub.2, or is thienyl or pyridyl; R.sup.10 is a fluorine or chlorine atom, hydroxy, nitro, amino, monoalkylamino, dialkylamino, or alkanoylamino; halogen is a fluorine, chlorine, bromine or iodine atom, X and Y, which can be the same or different, each is an oxygen atom or a sulfur atom; alkyl, hydroxyalkyl, alkoxy and alkanoyl unless otherwise indicated being up to 4 carbon atoms; with the proviso that R.sup.2 is ##STR9## when R.sup.1 and R.sup.3 to R.sup.8, inclusive, each are hydrogen atoms and X is an oxygen atom; and the physiologically acceptable salts thereof.
- 2. The compound of claim 1, 2-(tetrahydropyranyl)-4-carbonyl)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline.
- 3. The compound of claim 1, 2-(pyridyl-3-thiocarbonyl)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline.
- 4. The compound of claim 1, 1-hydroxy-2-(pyridyl-2-carbonyl)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline.
- 5. The compound of claim 1, 2-(pyridyl-4-thiocarbonyl)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline.
- 6. An anthelmintic composition comprising an anthelmintically effective amount per unit dosage of at least one compound of claim 1 in admixture with a pharmaceuticlly acceptable carrier or in admixture with an animal feed or feed concentrate.
- 7. An anthelmintic composition according to claim 6 adapted for oral administration.
- 8. An anthelmintic composition according to claim 6, in capsule form.
- 9. A method of treating helminthiasis which comprises administering to the infested patient an anthelmintically effective amount of at least one compound of claim 1.
- 10. A method of claim 9 wherein the patient is human.
- 11. A method of claim 9 wherin the patient is animal.
Priority Claims (1)
Number |
Date |
Country |
Kind |
2441261 |
Aug 1974 |
DEX |
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Parent Case Info
This is a division of application Ser. No. 817,467, filed July 20, 1977, now U.S. Pat. No. 4,120,961, filed as a division of Ser. No. 607,810, filed Aug. 26, 1975, now U.S. Pat. No. 4,051,243.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4001411 |
Seubert et al. |
Jan 1977 |
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4049659 |
Pohlke |
Sep 1977 |
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Divisions (2)
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Number |
Date |
Country |
Parent |
817467 |
Jul 1977 |
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Parent |
607810 |
Aug 1975 |
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