Role of Epigenetically Active Environmental Compounds in Neurodevelopmental Disorders

Information

  • Research Project
  • 10271253
  • ApplicationId
    10271253
  • Core Project Number
    R21ES030804
  • Full Project Number
    5R21ES030804-02
  • Serial Number
    030804
  • FOA Number
    PA-19-053
  • Sub Project Id
  • Project Start Date
    9/25/2020 - 3 years ago
  • Project End Date
    8/31/2022 - a year ago
  • Program Officer Name
    HOLLANDER, JONATHAN
  • Budget Start Date
    9/1/2021 - 2 years ago
  • Budget End Date
    8/31/2022 - a year ago
  • Fiscal Year
    2021
  • Support Year
    02
  • Suffix
  • Award Notice Date
    8/26/2021 - 2 years ago

Role of Epigenetically Active Environmental Compounds in Neurodevelopmental Disorders

PROJECT SUMMARY Neurodevelopmental disorders (NDDs), are increasingly recognized as originating from dysregulation of early brain development, which represents a window of vulnerability to environmental compounds. Environmental compounds may alter neurodevelopment via epigenetic mechanisms, which may not induce massive cell death, but change the brain function through their epigenetic effect on stem cell fate and lineage development. However, tools to systematically examine the epigenetic impact of environment on neurodevelopment are lacking. Here we employ Microscopic Imaging of Epigenetic Landscape (MIEL) to screen ToxCast Phase III chemical library (4700 compounds) and to characterize hits that alter epigenetic landscape of human neural precursors without inducing cytotoxicity. Recognizing environmental insults and understanding their mechanism of action will enable the development of regulations and guidelines aimed at avoiding such insults and the development of antidotes and protective agents when exposure is unavoidable.

IC Name
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
  • Activity
    R21
  • Administering IC
    ES
  • Application Type
    5
  • Direct Cost Amount
    125000
  • Indirect Cost Amount
    118750
  • Total Cost
    243750
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    113
  • Ed Inst. Type
  • Funding ICs
    NIEHS:243750\
  • Funding Mechanism
    Non-SBIR/STTR RPGs
  • Study Section
    NAL
  • Study Section Name
    Neurotoxicology and Alcohol Study Section
  • Organization Name
    SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
  • Organization Department
  • Organization DUNS
    020520466
  • Organization City
    LA JOLLA
  • Organization State
    CA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    920371005
  • Organization District
    UNITED STATES