The application relates generally to rotatable syringe systems, and more particularly to biopsy syringe systems with rotatable needles.
Biopsy needles are often used to remove a cellular material to determine if a suspicious mass is malignant. If the mass is determined to be malignant, the cellular material is similarly used to identify the tumor-specific mutations that allow for personalized treatment.
Traditional biopsy needles, such as those disclosed in U.S. Pat. No. 9,084,465 B2 ('465 patent) fail to adequately collect enough cellular material on each pass, resulting in a need for multiple passes. However, requiring multiple passes during the procedure extends the overall length of the biopsy procedure and increases patient risk.
While certain aspects of conventional technologies have been discussed to facilitate disclosure of the invention, Applicants in no way disclaim these technical aspects, and it is contemplated that the claimed invention may encompass one or more of the conventional technical aspects discussed herein.
The present invention may address one or more of the problems and deficiencies of the prior art discussed above. However, it is contemplated that the invention may prove useful in addressing other problems and deficiencies in a number of technical areas. Therefore, the claimed invention should not necessarily be construed as limited to addressing any of the particular problems or deficiencies discussed herein.
In this specification, where a document, act or item of knowledge is referred to or discussed, this reference or discussion is not an admission that the document, act or item of knowledge or any combination thereof was at the priority date, publicly available, known to the public, part of common general knowledge, or otherwise constitutes prior art under the applicable statutory provisions; or is known to be relevant to an attempt to solve any problem with which this specification is concerned.
As understood herein, it is often necessary to make multiple needle insertions in the patient to obtain sufficient tissue for analysis. Multiple “sticks” is a drawback for both patient comfort and clinical efficiency. Occasionally the need for further biopsy “sticks” is not realized until after the patient has left the medical establishment and a technician discovers that insufficient tissue has been harvested for analysis, requiring the patient to return for additional, uncomfortable tissue harvesting.
Accordingly, to avoid drawing tissue samples of insufficient cells that as a consequence requires repetition, a rotating needle is driven by a motor to harvest significantly higher yields of cellular material, reducing cost and patient discomfort.
In an aspect, a device includes an elongated needle having a cutting tip and a hollow interior. A syringe is coupled to the needle for rotation of the needle relative to the syringe, with an evacuatable tissue chamber being established at least in part by the hollow interior of the needle. A motor is coupled to the needle to rotate the needle while the tissue chamber is evacuated, and the needle is disposed adjacent tissue to facilitate drawing cells from the tissue into the tissue chamber.
In example embodiments, the syringe includes a distal end configured as a connector, the needle is engaged with a needle hub, and the syringe is coupled to the needle by a coupling comprising at least a mating connector for the needle hub and a mating connector for the syringe connector. The example syringe includes a barrel and a plunger slidably disposed in the barrel and movable to evacuate the tissue chamber, and a valve such as a slide valve or stopcock or other valve structure is operably coupled to the coupling to lock vacuum in the tissue chamber.
In non-limiting implementations, the coupling may include at least one hollow fitting engaged with the needle hub. The hollow fitting includes a body that may be configured as a luer fitting and a driven gear circumscribing the body and meshed with a drive gear coupled to the motor. At least one support assembly is engaged with the hollow fitting to rotatably support the hollow fitting. The support assembly is coupled to the connector of the distal end of the syringe, if desired via at least one luer fitting. The hollow fitting that is engaged with the needle hub may rotate against an O-ring engaged with the support assembly.
In some implementations, the motor defines an axis of rotation, the needle defines a longitudinal axis, and the axis of rotation of the motor is co-linear with the longitudinal axis of the needle. In other implementations, the motor defines an axis of rotation, the needle defines a longitudinal axis, and the axis of rotation of the motor is offset from with the longitudinal axis of the needle. In this implementation a belt may couple the motor to the needle to cause the needle to rotate under influence of the motor. Or, driven and drive gears may couple the motor to the needle to cause the needle to rotate under influence of the motor.
In some examples, the needle is no larger than twenty-five (235) gauge and may be 25 gauge or 27 gauge. The needle may rotate at a speed in the range of sixty (60) revolutions per minute (RPM) to three hundred fifty (350) RPM, inclusive.
In example implementations, the syringe can include a barrel and a plunger slidably disposed in the barrel and proximally movable to evacuate the tissue chamber, and a plunger lock can be mounted on a proximal portion of the barrel. At least one notch can be formed in the plunger, with at least a portion of the plunger lock riding against the plunger until the notch is juxtaposed with the portion of the plunger lock to cause the portion of the plunger lock to engage the notch to impede distal movement of the plunger. The plunger can be rotatable in the barrel to disengage the portion of the plunger lock from the notch.
In another aspect, a device includes a needle, a needle hub supporting the needle, and a rotatable fitting connected to the needle hub. The rotatable fitting includes a body and a driven gear circumscribing the body. A support assembly is rotatably engaged with the rotatable fitting, and a syringe is coupled to the support assembly by at least one coupling. A fluid passageway for fluid communication between an interior of the needle and the syringe is established by the needle hub, rotatable fitting, and support assembly such that the syringe is manipulable to evacuate the interior of the needle. A motor is coupled to a drive gear that in turn is meshed with the driven gear to cause the needle to rotate under influence of the motor while the interior of the needle is evacuated.
In another aspect, a method includes retracting a syringe plunger proximally relative to a barrel of the syringe to a first proximal position and closing a vacuum opening in the barrel. After closing the vacuum opening, the method includes retracting the syringe plunger proximally relative to the barrel of the syringe to a second proximal position to evacuate the barrel. The second proximal position is more proximal than the first proximal position. The method includes advancing a needle in fluid communication with the barrel of the syringe into an object to be sampled, energizing a motor coupled to the needle to rotate the needle, and opening the vacuum opening to cause portions of the object to be sucked into the needle as the needle rotates. The method then includes deenergizing the motor, releasing the vacuum, withdrawing the needle from the object, and advancing the plunger distally to expel the portions of the object from the needle.
In some embodiments, the biopsy device includes a biopsy needle having a main body extending between a proximal end and a distal end. A connector is located at the proximal end and is configured to operably engage the motor, such that the motor can rotate the biopsy needle. A cutting tip located at the distal end and a central longitudinal axis extends between the proximal and distal ends. In addition, a hollow interior extends through the main body and the connector, such that the hollow interior of the needle is in fluidic communication with the tissue collector.
Some embodiments of the biopsy needle include a first cutting aperture disposed through the main body. The first cutting aperture has a rectangular shape with a long end of the rectangular shape extending parallel to the central longitudinal axis of the biopsy needle. A second cutting aperture is also disposed through the main body. The second cutting aperture has a rectangular shape identical to the first cutting aperture with a long end of the rectangular shape extending parallel to the central longitudinal axis of the biopsy needle. Each of the first and second cutting apertures creates a channel with a central axis extending from an exterior surface of an interior surface of the main body, and the central axes of the channels are aligned. Furthermore, the first and second cutting apertures are longitudinally spaced in a proximal direction from the distal end of the main body, such that there is a continuous portion of the main body between the first and second cutting apertures and the distal end of the main body.
In some embodiments, the motor further includes a rotational axis that is co-linear with the central longitudinal axis of the biopsy needle. Some embodiments include a belt coupling the motor to the biopsy needle to cause the biopsy needle to rotate under influence of the motor. Some embodiments further comprise at least driven and drive gears coupling the motor to the biopsy needle to cause the biopsy needle to rotate under influence of the motor.
Some embodiments further include a valve in operable communication with a tissue evacuation passage extending between the biopsy needle and the tissue chamber, wherein the valve can lock vacuum in the tissue evacuation passage. In some embodiments, the valve is a slide valve. The slide valve has a slidable actuator configured to occlude the tissue evacuation passage when slid into a closed position.
Some embodiments further include a connector on the proximal end of the biopsy needle is a luer connector. In some embodiments, at least one hollow fitting engages a needle connector. The hollow fitting comprises a body and a driven gear circumscribing the body and meshed with a drive gear coupled to the motor. Some embodiments further include the hollow fitting engaged with a needle connector rotates against an O-ring engaged with the drive housing.
In some embodiments, the biopsy needle is no larger than twenty-five (25) gauge. In some embodiments, the first and second cutting apertures are diametrically opposed from each other about the main body of the biopsy needle.
In some embodiments, each of the cutting apertures are defined by a boundary circumscribing the aperture and the boundary is generally flush with an exterior surface of the main body. In some embodiments, each cutting aperture includes a beveled channel wall extending between the interior and an exterior surface of the main body of the biopsy needle to direct tissue into the interior of the biopsy needle. In some embodiments, each of the cutting apertures includes an outwardly, laterally extending flange relative to the central longitudinal axis of the needle.
In some embodiments, each cutting aperture is the same distance from the distal end of the biopsy needle. In some embodiments, the first cutting aperture is longitudinally spaced from the second cutting aperture, such that the two cutting apertures are at different distances from the distal end of the biopsy needle.
In some embodiments, a portion of the biopsy needle proximal to the of the cutting apertures includes a plurality of annular grooves circumscribing an exterior surface of the biopsy needle.
Some embodiments further include a third and a fourth cutting aperture disposed through the main body. The third cutting aperture has a rectangular shape with a long end of the rectangular shape extending parallel to the central longitudinal axis of the biopsy needle. The fourth cutting aperture has a rectangular shape identical to the first cutting aperture with a long end of the rectangular shape extending parallel to the central longitudinal axis of the biopsy needle. The third and fourth cutting apertures are longitudinally spaced in the proximal direction from the distal end of the main body, such that the continuous portion of the main body is between the third and fourth cutting apertures and the distal end of the main body. In addition, the third and fourth cutting apertures are diametrically opposed from each other about the main body of the biopsy needle and the third cutting aperture is circumferentially spaced from the first cutting aperture by generally 45 degrees.
Some embodiments further include a plurality of annular grooves proximate the cutting apertures. In some embodiments, the distal end of the biopsy needle includes a beveled tip.
The details of the present application, both as to its structure and operation, can best be understood in reference to the accompanying drawings, in which like reference numerals refer to like parts.
For a fuller understanding of the invention, reference should be made to the following detailed description, taken in connection with the accompanying drawings, in which:
Now describing the details of
The barrel 14 has a distal end and a proximal end. The proximal end has laterally extending finger supports 16. The needle 12 also has a distal end and a proximal end, and the distal end of the needle is formed with a point. The proximal end of the needle is operatively coupled to the distal end of the barrel.
The syringe also includes a plunger 18 with a distal end and a proximal end. The distal end of the plunger is located within the barrel 14 to advance liquid medication out of the barrel into and through the needle and into the patient. The proximal end of the plunger is adapted to be depressed by a thumb of a care giver with fingers on the finger supports. The barrel 14 and the needle 12 and the plunger 18 share a common central axis.
A pulley 20 is next provided. The pulley 20 is located between the proximal end of the needle 12 and the distal end of the barrel 14. The pulley 20 is attached to the needle for rotational movement therewith but with no axial movement of the needle. The pulley 20 is coupled to the barrel 14 for rotation independent of the barrel 14.
Next, a drive assembly is provided. The drive assembly includes a housing 22 in a cylindrical configuration with a distal end and proximal end. A source 24 of electrical potential is provided within and adjacent to the proximal end of the housing. A motor 26 is provided within the housing 22 adjacent the distal end of the housing 22. A drive shaft 28 is coupled to the motor 26. The drive shaft 28 extends forward from the motor 26 and the housing 22 to a location laterally spaced from the pulley 20. A switch 30 is provided to activate and inactivate the motor 26.
A belt 32 is trained around the drive shaft 28 and the pulley 20 to rotate the pulley 20 and the needle 12 for capturing tissue from within a patient and for extracting from the patient captured tissue for analysis.
In operation, any of the needles described herein can be placed at the edge of the tissue, such as a nodule, under ultrasound imaging or other imaging techniques such as ultrasound computed tomography (CT) guidance, magnetic resonance imaging (MRI) fluoroscopic guidance, and MRI imaging guidance. When the distal end of the plunger is withdrawn, a vacuum is created in the needle to withdraw tissue to be analyzed. The motor is energized with the switch on the syringe so that the procedure can be done with one hand. Once activated, the rotating needle is advanced in and out of the lesion, changing direction with each pass if desired. Once a sample is seen in the needle hub or syringe, the motor can be turned off and the needle removed. The sample can then be placed on slides for pathology evaluation. The motor can cause the needle to spin from 60 to 350 revolutions per minute (RPM), depending on what is determined to be the optimum speed. The needle may be advanced into the tissue sample for a period of 10 to 30 seconds or until a blood drop appears in the hub of the needle or syringe. During the fine needle aspirating (FNA), the rotating needle, preferably a 25 gauge needle, will be well visualized under ultrasound imaging. There will be for the most part only one pass into the nodule needed due to the highly effective cell shearing action of the rotating needle.
Now referring to
A syringe 708 is coupled to the needle 702 for rotation of the needle 702 relative to the syringe 708. An evacuatable tissue chamber 710 is established at least in part by the hollow interior of the needle 702. A motor, shown and described further below, is supported in a drive housing 712 and is coupled to the needle 702 to rotate the needle 702 while the tissue chamber 710 is evacuated and the needle 702 is disposed adjacent tissue to facilitate drawing cells from the tissue into the tissue chamber 710.
The syringe 708 typically includes a barrel 714 and a plunger 716 slidably disposed in the barrel 714 and movable to evacuate the tissue chamber 710. A valve such as a slide valve 718 (
Completing the description of
In example embodiments, as best shown in
Indeed, and now referring to
A support assembly 736 may be engaged with the hollow fitting 724 to rotatably support the hollow fitting 724. Note that the output shaft 737 of the gear assembly 734 may extend through a hole of the support assembly 736 to connect to the drive gear 730, with the support assembly 734 radially supporting the output shaft 737 as the shaft spins.
The support assembly 736 is coupled to the connector 720 of the distal end of the syringe 708, if desired via at least one luer fitting 738 that may be, e.g., glued to the support assembly 736. When the slide valve 718 is included (or another valve such as a stopcock as set forth further below), the luer fitting 738 is connected to the distal end of the valve 718, which in turn is connected at its proximate end to the connector 720 of the syringe. The valve connectors may be configured as luer fittings. A continuous fluid passageway is formed from the tip of the needle 702 into the barrel 714 of the syringe by the train of components described above, with the valve 718 being operable to selectively occlude the fluid passageway to draw a vacuum in the system when the plunger is retracted proximally.
The hollow fitting 724 may rotate on a boss 740 of the support assembly 736, against an O-ring 740 that circumscribes the boss 740 to establish a fluid seal between the support assembly 736 and hollow fitting 724 during rotation.
As can be appreciated in reference to in
Now referring to
In operation, in some embodiments two to three drops of cells are sought to be obtained from tissue, to be dispensed as discussed below onto a microscope slide for analysis. This amount of sample typically can be held within the needle and hub alone, but to provide indication of adequate tissue harvest, enough tissue may be excised to fill not only the needle but also the fluid passageway between the syringe and needle and into the syringe, where tissue can be visualized and hence indicate sufficient sample has been obtained. With this in mind, the portion of the fluid passageway between the syringe and needle may be considered to be “dead space” which preferably is minimized in volume by making the diameter of the fluid passageway as small as practicable, since the fluid passageway must be filled with sample material before the caregiver sees anything in the syringe.
At block 1406 the needle is next advanced into the target tissue. This procedure preferably is done in conjunction with ultrasound imaging. The ultrasound probe is held with one hand to image where the needle is and the target tissue.
Proceeding to block 1408, the motor is energized using, e.g., a slide switch, a moment switch, or other activating element. Vacuum in the syringe is broken by, e.g., opening the vacuum valve, which causes cells from the tissue to be sucked into the needle through the cutting tip with the needle constantly rotating the entire time. When tissue is visualized in the needle hub or syringe, indicating sufficient harvest, the motor is deenergized at block 1410, the vacuum is blocked, and the needle withdrawn from the patient.
Moving to block 1412, the plunger lock is released. Opening the vacuum valve without releasing the plunger should be avoided, as this will result in all the cells surging up into the syringe. When the plunger lock is released it will return to the relaxed position it assumed at block 1400, with some air, e.g., two to three milliliters, remaining in the barrel. At this point, at block 1414 the vacuum valve is opened. Moving to block 1416, the plunger is advanced distally to expel the cells out of the tip of the needle, typically onto a microscope slide for analysis. Note that owing to the small needle gauge in some embodiments, tissue cores are not harvested, only cells that are scraped from the tissue by the rotating needle.
While
Now referring to
In some examples, a flexible shaft design may implement the rotational train of elements above and advanced down a bronchoscope or other endoscope. The needle may be larger than twenty-five gauge if desired to harvest tissue cores for biopsies.
Some embodiments of the present invention include a biopsy needle that dramatically increases cellular material (i.e., cells) yield per pass. By collecting more cellular material per pass, the biopsy procedure requires fewer passes and is completed in shorter periods of time over conventional biopsy needles.
Referring now to
Generally, biopsy needle 3010 comprises elongated shaft 3012 extending along central longitudinal axis 3014 from proximal end 3016 to distal end 3018. Elongated shaft 3012 includes internal surface 3020, external surface 3022, and body 3024 extending between internal surface 3020 and external surface 3022 of elongated shaft 3012. Moreover, internal surface 3020 of elongated shaft 3012 defines bore 3026, such that elongated shaft 3012 is hollow to facilitate the collection of cellular material from within the biopsy area.
Specifically, upon insertion of biopsy needle 3010 within a patient, the biopsy needle is manipulated (e.g., rotated and/or translated about its central longitudinal axis 3014) to enable the collection of cellular material and fluid. Once the cellular material is dislodged via the manipulation of biopsy needle 3010, the cellular material flows within bore 3026 from distal end 3018 to proximal end 3016 of biopsy needle 3010 and is collected within a collection reservoir (e.g., syringe or other devices) in mechanical communication with proximal end 3016 of biopsy needle 3010. Furthermore, distal end 3018 of biopsy needle 3010 includes retrieval section 3028 configured to scrape, tear, bump, grind, cut, sheer, hammer, or slash portions of intact cellular material located within the biopsy area to facilitate their collection within the collection reservoir through bore 3026.
Cutting edge 3030 includes a first cutting design having a plurality of teeth 3036. Each tooth 3038 comprises face 3040, back 3042, and point 3044. A neutral rake angle of 0 degrees (i.e., rake angle being perpendicular to the direction of cut) is shown. The rake angle determines the angle of the cutting face 3040 of each tooth 3038. Moreover, having a rake angle of 0 degrees results in a vertical tooth 3038 that cuts faster and more aggressively. Furthermore, each tooth 3038 of cutting edge 3030 has a fleam angle (or bevel angle) of 0 degrees. In particular, the fleam is the angle across face 3040 of tooth 3038. The fleam permits each tooth 3038 to perform a tip-cut action—chiseling off cellular material as biopsy needle 3010 is manipulated and rotated about central longitudinal axis 3014.
In some embodiments, as depicted in
The embodiment of retrieval section 3028 as provided in
Cutting edge 3030 of beveled wall 3056 is formed at the intersection of external surface 3022 and wall 3056. In some embodiments, a line intersecting the midpoints of both major aperture edge 3050 and minor aperture edge 3052 is aligned perpendicular to central longitudinal axis 3014 of needle 3010. In some embodiments, the line intersecting the midpoints of both major aperture edge 3050 and minor aperture edge 3052 is non-parallel to central longitudinal axis 3014 of needle 3010. There orientations ensure that the rotation of needle 3010 about central longitudinal axis 3014 cut the adjacent tissue.
As retrieval section 3028 of biopsy needle 3010 is rotated about central longitudinal axis 3014, cutting edge 3030 engages with cellular material located within the biopsy area. Once the cellular material is dislodged from within biopsy area by cutting edge 3030, the cellular material is directed within bore 3026 via the beveled orientation of wall 3056 and preferably also a vacuum force created by the collection reservoir coupled with the proximal end 3016 of biopsy needle 3010. Additionally, multiple crescent cutting apertures 3048 can be disposed in distinct orientations or arrangements. Thus, regardless of how biopsy needle 3010 is manipulated, at least one cutting edge 3030 will engage the tissue of the biopsy area for collection.
An embodiment of retrieval section 3028 of biopsy needle 3010 as shown in
Each cutting aperture 3048 is disposed through body 3024 of elongated shaft 3012 from internal surface 3020 to external surface 3022. More particularly, channel 3062 includes first portion 3064 and second portion 3066. First portion 3064 of channel 3062 includes a beveled edge and shares common boundary 3070 with second portion 3066. Channel 3062 includes channel axis 3072 disposed in an orthogonal relationship with central longitudinal axis 3014 of elongated shaft 3012.
Moreover, embodiments of cutting apertures 3048 disposed through body 3024 of retrieval section 3028 may include any other shape, size, or design of cutting apertures 3048 that is in line with any other embodiment of retrieval section 3028 disclosed herein.
Conical protrusions 3058 extend from external surface 3022 of elongated shaft 3012 from first protrusion end 3074 to second protrusion end 3076. First protrusion end 3074 of conical protrusion 3058 has a protrusion angle δ and second protrusion end 3076 has protrusion angle ε. Protrusion angle δ is a smaller angle than protrusion angle ε. Moreover, conical protrusion 3058 is configured to be in mechanical communication with the biopsy area and tears cellular material free, which is then collected through cutting aperture 3048 and/or bore opening 3060.
Each cutting aperture 3048 includes cutting edge 3030 extending outwardly away from external surface 3022. Each cutting edge 3030 is configured to engage with the tissue within the biopsy area, thereby dislodging the cellular material. Once dislodged, the cellular material is collected within bore 3026 via cutting aperture 3048 and/or bore opening 3060 disposed at distal end 3018 of biopsy needle 3010. Moreover, as depicted in
An embodiment shown in
The material dislodged during manipulation of retrieval section 3028 is captured through bore opening 3060 and/or collection apertures 3086. Collection apertures 3086 may be disposed above, below, and or within knurling portion 3084 to facilitate the capture of dislodged cellular materials.
In some embodiments
In an embodiment, retrieval section 3028 may include one or more cutting apertures disposed within the body of retrieval section 3028. In such embodiments, the cutting apertures may be in line with any other embodiment of retrieval section 3028 disclosed herein.
In an embodiment shown in
Furthermore, retrieval section 3028 of includes a pair of diametrically opposed cutting apertures 3048 disposed at vertices 3094 of major axis 3090 of body 3024 of elongated shaft 3012 from internal surface 3020 to exterior surface 3022. Each cutting aperture includes cutting edge 3030 extending outwardly from external surface 3022 of body 3024. Cutting edge 3030 is configured to engage with the tissue within the biopsy area. Thus, when the biopsy needle is manipulated, cutting edge 3030 dislodges cellular material, which is collected within bore 3026 via cutting apertures 3048 and/or bore opening 3060.
Moreover, embodiments of cutting apertures 3048 disposed through body 3024 of retrieval section 3028 may include any other shape, size, or design of cutting apertures 3048 in line with any other embodiment of retrieval section 3028 disclosed herein.
In some embodiments, as shown in
Additionally, cutting edges 3030 are flush with and follow the curvature (i.e., circumference) of external surface 3022 of retrieval section 3028. In such embodiments, the manipulation of retrieval section 3028 laterally in an orthogonal relationship with axis 3014 forces tissues within the biopsy area in cutting apertures 3048. Thus, upon rotation of retrieval section 3028 about axis 3014 in either a clockwise or counterclockwise rotation, at least one of the cutting edges 3030 sheers off the tissue disposed within cutting aperture 3048 for sample collection.
Moreover, embodiments of cutting apertures 3048 disposed within body 3024 of retrieval section 3028 may include any other shape, size, or design of cutting apertures 3048 that are in line with any other embodiment of retrieval section 3028 disclosed herein.
Some embodiments, a depicted in
As illustrated in
Moreover, some embodiments may include grooves 3083 without include cutting apertures 3048 as depicted in
Some embodiments include biopsy needle 3010 having a proximal section with knurling 3085 or other friction increasing features. The friction increasing features on the proximal portion aid in retaining a secure connection with needle 3010.
Referring back to
In some embodiments, the circumferential spacing between two adjacent cutting apertures is between 5 and 90 degrees. In some embodiments, the circumferential spacing between two adjacent cutting apertures is between 5 and 180 degrees. It should also be understood that the circumferential spacing of cutting apertures may apply to the other embodiments disclosed herein.
While the particular device is herein shown and described in detail, it is to be understood that the subject matter which is encompassed by the present invention is limited only by the claims.
Components included in one embodiment can be used in other embodiments in any appropriate combination. For example, any of the various components described herein and/or depicted in the FIGS. may be combined, interchanged or excluded from other embodiments.
“A system having at least one of A, B, and C” (likewise “a system having at least one of A, B, or C” and “a system having at least one of A, B, C”) includes systems that have A alone, B alone, C alone, A and B together, A and C together, B and C together, and/or A, B, and C together, etc.
This nonprovisional application is a continuation in part of and claims priority to nonprovisional application Ser. No. 17/524,219, entitled “Rotatable Syringe Device,” filed Nov. 11, 2021 by the same inventor(s), which is a divisional of and claims priority to nonprovisional application Ser. No. 16/013,522, entitled “Rotatable Syringe System,” filed Jun. 20, 2018 by the same inventor(s), which claims priority to provisional application No. 62/652,367 filed Apr. 4, 2018 by the same inventor(s). This nonprovisional application also claims priority to provisional application No. 63/122,671, entitled “Biopsy Needle with Cutting Structure and Related Method of Manufacture,” filed Dec. 8, 2020 by the same inventor(s).
Number | Date | Country | |
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62652367 | Apr 2018 | US | |
63122671 | Dec 2020 | US |
Number | Date | Country | |
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Parent | 16013522 | Jun 2018 | US |
Child | 17524219 | US |
Number | Date | Country | |
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Parent | 17524219 | Nov 2021 | US |
Child | 17545038 | US |