RP2: Connectivity and Circuit Organization

Information

  • Research Project
  • 10226041
  • ApplicationId
    10226041
  • Core Project Number
    U19NS112959
  • Full Project Number
    5U19NS112959-03
  • Serial Number
    112959
  • FOA Number
    RFA-NS-19-003
  • Sub Project Id
    7297
  • Project Start Date
    9/15/2019 - 5 years ago
  • Project End Date
    6/30/2024 - 5 months ago
  • Program Officer Name
  • Budget Start Date
    7/1/2021 - 3 years ago
  • Budget End Date
    6/30/2022 - 2 years ago
  • Fiscal Year
    2021
  • Support Year
    03
  • Suffix
  • Award Notice Date
    9/9/2021 - 3 years ago

RP2: Connectivity and Circuit Organization

Project Summary: Project 2 ? Connectivity and Circuit Organization Neural circuits in the cervical spinal cord generate a range of rhythmic and dexterous motor behaviors that are essential for life. These circuits, aside from being important in their own right, serve as a window into how other brain areas are functionally organized by providing a critical readout of behavior, namely motor action. The analyses in this project will use cutting-edge genetic tools and anatomical approaches, many of which were developed at the Salk Institute, to create a scalable and interactive connectivity map of the pre- motor interneuron circuits in the cervical spinal cord. This connectivity map will be registered to motor pools innervating specific forelimb muscles in order for the connectivity datasets to be informative for the modeling and interpretation of motor behaviors that are key components of this Team SCC initiative. Intersectional mouse genetics will be used to target specific populations of spinal interneurons and annotate key information about position, and connectivity, in order to generate a physical wiring diagram for forelimb pre- motor circuits. The pre-motor wiring diagram will serve as a template for a subsequent more expansive analysis of spinal connectivity that will include sensory, propriospinal, and descending connections to forelimb pre-motor neurons. These studies, when completed, will provide unparalleled insights into the organization of the spinal motor circuitry and the motor system as a whole. They will also lead to a better understanding of the cellular interactions and neural computations that give rise to rhythmic and skilled forelimb movements.

IC Name
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
  • Activity
    U19
  • Administering IC
    NS
  • Application Type
    5
  • Direct Cost Amount
    354736
  • Indirect Cost Amount
    327776
  • Total Cost
  • Sub Project Total Cost
    682512
  • ARRA Funded
    False
  • CFDA Code
  • Ed Inst. Type
  • Funding ICs
    NINDS:682512\
  • Funding Mechanism
    Non-SBIR/STTR RPGs
  • Study Section
    ZNS1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    SALK INSTITUTE FOR BIOLOGICAL STUDIES
  • Organization Department
  • Organization DUNS
    078731668
  • Organization City
    La Jolla
  • Organization State
    CA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    920371002
  • Organization District
    UNITED STATES