RPE Signaling in Ocular Health and Disease

Information

  • Research Project
  • 10250509
  • ApplicationId
    10250509
  • Core Project Number
    R01EY029267
  • Full Project Number
    5R01EY029267-04
  • Serial Number
    029267
  • FOA Number
    PA-16-160
  • Sub Project Id
  • Project Start Date
    9/30/2018 - 5 years ago
  • Project End Date
    8/31/2022 - a year ago
  • Program Officer Name
    NEUHOLD, LISA
  • Budget Start Date
    9/1/2021 - 2 years ago
  • Budget End Date
    8/31/2022 - a year ago
  • Fiscal Year
    2021
  • Support Year
    04
  • Suffix
  • Award Notice Date
    9/8/2021 - 2 years ago

RPE Signaling in Ocular Health and Disease

RESEARCH SUMMARY This proposal describes experiments to address cellular functions of two transmembrane proteins, LRP2 and MFRP, that when mutated in humans and animal models cause a spectrum of ocular pathologies, including retinal dystrophies and refractive errors. LRP2 is a large transmembrane protein of the LDL- receptor related protein (LRP) family. MFRP is also a transmembrane protein and was named for its C- terminal and extracellular cysteine rich Frizzled domain, although it also has CUB and LDLA domains. Within eyes, both LRP2 and MFRP are specifically expressed on RPE and ciliary epithelial cells. Through three Specific Aims, we probe (1) the potential functional cooperatively between LRP2 and MFRP in receiving and transducing signals and regulating cellular processes (2) their involvement in recruitment and activation of macrophages in normal eye growth and during pathology, and (3) their protein binding partners and the possibility they interact directly. The proposed research will provide fundamental insights into regulation of specific signaling pathways and cellular processes of RPE cells with emphasis on their role in extracellular matrix homeostasis and in regulation of microglia and macrophages during ocular health and disease. Broadly, our studies will also help understand the links between ocular fibrosis and retinal pathologies.

IC Name
NATIONAL EYE INSTITUTE
  • Activity
    R01
  • Administering IC
    EY
  • Application Type
    5
  • Direct Cost Amount
    285797
  • Indirect Cost Amount
    154330
  • Total Cost
    440127
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    867
  • Ed Inst. Type
    SCHOOLS OF MEDICINE
  • Funding ICs
    NEI:440127\
  • Funding Mechanism
    Non-SBIR/STTR RPGs
  • Study Section
    BVS
  • Study Section Name
    Biology of the Visual System Study Section
  • Organization Name
    MEDICAL COLLEGE OF WISCONSIN
  • Organization Department
    ANATOMY/CELL BIOLOGY
  • Organization DUNS
    937639060
  • Organization City
    MILWAUKEE
  • Organization State
    WI
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    532263548
  • Organization District
    UNITED STATES