Claims
- 1. A recombinant spherical outer wall glycoprotein 58 (SOWgp58).
- 2. An antigen for serodiagnosis of coccidioidomycosis comprising a recombinant spherical outer wall glycoprotein.
- 3. The antigen of claim 2, wherein the glycoprotein comprises SOWgp58.
- 4. The antigen of claim 2, wherein the glycoprotein comprises an isolated DNA sequence substantially as shown in Sequence ID No. 1.
- 5. The antigen of claim 2, wherein the glycoprotein comprises an amino acid sequence substantially as shown in Seq. ID No. 2.
- 6. The antigen of claim 2, wherein the glycoprotein comprises an isolated DNA sequence substantially as shown in Seq. ID No. 3.
- 7. The antigen of claim 2, wherein the glycoprotein comprises an amino acid sequence substantially as shown in Seq. ID No. 4.
- 8. The antigen of claim 2, wherein the glycoprotein comprises an amino acid sequence substantially as shown in Seq. ID No. 5.
- 9. The antigen of claim 2, wherein the glycoprotein comprises an amino acid sequence substantially as shown in Seq. ID No. 6.
- 10. The antigen of claim 2, wherein the glycoprotein comprises an amino acid sequence substantially as shown in Seq. ID No. 7.
- 11. The antigen of claim 2, wherein the glycoprotein comprises an amino acid sequence substantially as shown in Seq. ID No. 8.
- 12. The antigen of claim 2, wherein the glycoprotein comprises an isolated DNA sequence substantially as shown in Seq. ID No. 9.
- 13. The antigen of claim 2, wherein the glycoprotein comprises an amino acid sequence substantially as shown in Seq. ID No. 10.
- 14. The antigen of claim 2, wherein the glycoprotein comprises an isolated DNA sequences substantially as shown in Seq. ID No. 11.
- 15. The antigen of claim 2, wherein the glycoprotein comprises an amino acid substantially as shown in Seq. ID No. 12
- 16. An isolated nucleic acid comprising a sequence that hybridizes under highly stringent conditions to a hybridization probe the nucleotide sequence of which consists of Seq. ID No. 1, or the complement of Seq. ID No. 1.
- 17. An isolated nucleic acid comprising a sequence that hybridizes under highly stringent conditions to a hybridization probe the nucleotide sequence of which consists of Seq. ID No. 3, or the complement of Seq. ID No. 3.
- 18. An isolated nucleic acid comprising a sequence that hybridizes under highly stringent conditions to a hybridization probe the nucleotide sequence of which consists of Seq. ID No. 9, or the complement of Seq. ID No. 9.
- 19. An isolated nucleic acid comprising a sequence that hybridizes under highly stringent conditions to a hybridization probe the nucleotide sequence of which consists of Seq. ID No. 11, or the complement of Seq. ID No. 11.
- 20. A purified polypeptide, the amino acid of which comprises Seq. ID No. 2 with 0 to 20 conservative amino acid substitutions.
- 21. A purified polypeptide, the amino acid of which comprises Seq. ID No. 4 with 0 to 20 conservative amino acid substitutions.
- 22. A purified polypeptide, the amino acid of which comprises Seq. ID No. 5 with 0 to 20 conservative amino acid substitutions.
- 23. A purified polypeptide, the amino acid of which comprises Seq. ID No. 6 with 0 to 20 conservative amino acid substitutions.
- 24. A purified polypeptide, the amino acid of which comprises Seq. ID No. 7 with 0 to 20 conservative amino acid substitutions.
- 25. A purified polypeptide, the amino acid of which comprises Seq. ID No. 8 with 0 to 20 conservative amino acid substitutions.
- 26. A purified polypeptide, the amino acid of which comprises Seq. ID No. 10 with 0 to 20 conservative amino acid substitutions.
- 27. A purified polypeptide, the amino acid of which comprises Seq. ID No. 12 with 0 to 20 conservative amino acid substitutions.
- 28. A method to elicit a proliferative response of monocytes of skin test positive animals, comprising introducing into the animal a composition comprising the purified antigen of claim 2.
- 29. A kit comprising a vessel or vessels containing the purified antigen of claim 2.
- 30. A method comprising:
a) obtaining a sample of nucleic acid from a subject; and b) determining the identify of the nucleotide encoding the SOWgp58, SOWgp66 and/or SOW82 genes.
- 31. The method of claim 30, wherein the determining step comprises sequencing at least a portion of a nucleic acid molecule encoding at least one of said genes.
- 32. The method of claim 30, wherein the determining step comprises amplifying at least a portion of a nucleic acid molecule encoding at least one of said genes.
RELATED APPLICATION
[0001] The present application is related to U.S. Provisional Application Serial No. 60/202,754 filed May 8, 2000.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60202754 |
May 2000 |
US |