RUI: Correlating Effects of Boronic Acid Substitution on Flavonoid Subclasses

Information

  • NSF Award
  • 0316532
Owner
  • Award Id
    0316532
  • Award Effective Date
    8/1/2003 - 21 years ago
  • Award Expiration Date
    7/31/2008 - 16 years ago
  • Award Amount
    $ 269,000.00
  • Award Instrument
    Standard Grant

RUI: Correlating Effects of Boronic Acid Substitution on Flavonoid Subclasses

This proposal addresses the correlation of physical, spectroscopic, chemical and biological effects of boronic acid substitution on flavonoid subclasses. Specific objectives include: (1) synthesis of a new subclass of synthetic flavonoids -boronic acid substituted chalcones (BASCs), (2) development of deeply colored BASCs as (a) novel molecular sensors for cyanide and amines, (b) solvatochromic indicators, (c) DNA photonucleases, and (d) NIR absorbing dyes, (3) investigation of the antimicrobial activity of hydroxylated BASCs, and (4) use of BASCs as model systems for the development of other boronic acid substituted flavonoids (aurones, flavones, anthocyanins). The 'ortho Lewis acid effect' highlighted in these compounds will be assessed calculationally and applied in the rational design and development of tunable electron acceptor subunits for internal charge transfer (ICT) materials.<br/><br/>With the support of a Research at Undergraduate Institutions award from the Organic and Macromolecular Chemistry Program, Professor Desmond H. Murray, of the Department of Chemistry at Andrews University, is studying the synthesis and properties of a unique class of molecules that incorporate two unusual substructures. The juxtaposition of these two "functional groups" leads to a diverse range of unusual and important molecular properties, leading to potential applications in the areas of molecular sensors for toxic environmental and industrial agents, molecular sensors for a-hydroxy acids and carbohydrates for agricultural, food and medical applications, and novel antimicrobial agents. Professor Murray's research program actively involves a diverse group of undergraduates and high school students, improves the levels of inclusion of research-active students from underrepresented groups, and provides early opportunities for students to experience the excitement of scientific discovery.

  • Program Officer
    Tingyu Li
  • Min Amd Letter Date
    7/29/2003 - 21 years ago
  • Max Amd Letter Date
    7/7/2005 - 19 years ago
  • ARRA Amount

Institutions

  • Name
    Andrews University
  • City
    Berrien Springs
  • State
    MI
  • Country
    United States
  • Address
    Andrews University
  • Postal Code
    491040670
  • Phone Number
    2694713100

Investigators

  • First Name
    Desmond
  • Last Name
    Murray
  • Email Address
    murrayd@andrews.edu
  • Start Date
    7/29/2003 12:00:00 AM

FOA Information

  • Name
    Other Applications NEC
  • Code
    99

Program Element

  • Text
    SYNTHESIS
  • Code
    1948

Program Reference

  • Text
    UNASSIGNED
  • Code
    0
  • Text
    UNDERGRADUATE EDUCATION
  • Code
    9178
  • Text
    RES IN UNDERGRAD INST-RESEARCH
  • Code
    9229
  • Text
    OTHER RESEARCH OR EDUCATION
  • Text
    SCIENCE, MATH, ENG & TECH EDUCATION