RUI: gamma-C-Alkylation of 1,3-Dicarbonyl Compounds using Equilibrating Conditions

Information

  • NSF Award
  • 1058212
Owner
  • Award Id
    1058212
  • Award Effective Date
    2/15/2011 - 14 years ago
  • Award Expiration Date
    1/31/2015 - 10 years ago
  • Award Amount
    $ 179,101.00
  • Award Instrument
    Standard Grant

RUI: gamma-C-Alkylation of 1,3-Dicarbonyl Compounds using Equilibrating Conditions

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professors Brad Andersh and Wayne Bosma of Bradley University will use a tandem approach of synthesis and computational chemistry to investigate the mechanism and the scope and limitations of gamma-carbon-alkylation reactions of 1,3-dicarbonyl compounds using equilibrating bases such as carbonates and alkoxides. The specific mechanistic questions that will be addressed are: (1) why gamma-alkylation rather than alpha-alkylation occurs when an equilibrating base is used and (2) how the gamma-anion of a 1,3-dicarbonyl compound forms. <br/><br/>The development of chemical processes that are cost-effective and environmentally safe is an area of emphasis in the chemical community. The goal of the proposed research is to understand and exploit a new method for selectively modifying organic compounds at one or more similar sites. The proposed methodology is procedurally less complex than existing methods and will allow for new greener chemical processes. The broader impacts of the project include (1) providing scientists with a greater understanding of this green method, and (2) the training of future scientists by providing research opportunities for undergraduate and high school students.

  • Program Officer
    Suk-Wah Tam-Chang
  • Min Amd Letter Date
    1/6/2011 - 14 years ago
  • Max Amd Letter Date
    1/6/2011 - 14 years ago
  • ARRA Amount

Institutions

  • Name
    Bradley University
  • City
    Peoria
  • State
    IL
  • Country
    United States
  • Address
    1501 West Bradley Avenue
  • Postal Code
    616250001
  • Phone Number
    3096767611

Investigators

  • First Name
    Bradley
  • Last Name
    Andersh
  • Email Address
    bja@bradley.edu
  • Start Date
    1/6/2011 12:00:00 AM
  • First Name
    Wayne
  • Last Name
    Bosma
  • Email Address
    bosma@bradley.edu
  • Start Date
    1/6/2011 12:00:00 AM