Claims
- 1. A pharmaceutical composition for treating sleep disorders which comprises an effective amount of (S)-1-[(10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quinolizin-1-yl)carbonyl]-3-ethoxypyrrolidine and a therapeutically inert carrier material.
- 2. A pharmaceutical composition in accordance with claim 1, wherein the effective amount is in the range of from about 0.1 mg to about 100 mg.
- 3. A method of treating sleep disorders which comprises administering to a host in need of such treatment an effective amount of (S)-1-[(10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quinolizin-1-yl)carbonyl]-3-ethoxypyrrolidine.
- 4. A method in accordance with claim 3, wherein the effective amount is in the range of from about 0.1 mg to about 100 mg.
Priority Claims (1)
Number |
Date |
Country |
Kind |
228/91 |
Jan 1991 |
CHX |
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Parent Case Info
This is a division, of application Ser. No. 07/818,653 filed Jan. 6, 1992, now U.S. Pat. No. 5,281,711, issued Jan. 25, 1994.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4889848 |
Fischer et al. |
Dec 1989 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
183994 |
Jun 1986 |
EPX |
304087 |
Feb 1989 |
EPX |
Non-Patent Literature Citations (5)
Entry |
Fischer et al., "Tricyclic pyridine derivatives with high affinity to the central benzodiazepine receptor", Helv. Chim. Acta 73:763-781 (1990). |
Tamasawa et al., "Stereoselectivity of a potent calcium antagonist, 1-benzyl-3-pyrrolidinyl methyl 2,6-dimethyl-4 -(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate", J. Med. Chem. 29:2504-2511 (1986). |
Bhat et al., "Synthetic routes to chiral 3-pyrrolidinols", Synth. Comm. 15:587-598 (1985). |
Scherschlicht et al., "Effects of oral and intravenous midazolam, triazolam and flunitrazepam on the sleep-wakefulness cycle of rabbits", Br. J. Clin. Pharmac. 16:29S-35S (1983). |
Chemical Abstracts Service, CA 107:134200, 1986. |
Divisions (1)
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Number |
Date |
Country |
Parent |
818653 |
Jan 1992 |
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