SAFE HARBOR LOCI

SEQUENCE LISTING

The instant application contains a Sequence Listing which will be submitted via Patent Center and is hereby incorporated by reference in its entirety. Said XML copy, created on Aug. 29, 2023, is named ANB-203D2_SL.xml and is 845,305 bytes in size.

BACKGROUND

Cancer continues to present a significant clinical burdSen despite the substantial research efforts and scientific advances in cancer therapies. Blood and bone marrow cancers are frequently diagnosed cancer types, including multiple myelomas, leukemia, and lymphomas. Current treatment options for these cancers are not effective for all patients and/or can have substantial adverse side effects. Other types of cancer also remain challenging to treat using existing therapeutic options. Cancer immunotherapies are a promising solution because they can be highly specific, allowing for increased therapeutic effectiveness and the mitigation of side effects.

Genetically engineered immune cell therapy is a growing field with promising applications for the treatment of diseases including, but not limited to, cancer. Through the alteration of coding and/or non-coding genomic regions, researchers are identifying transgenes and insertion sites within cells that facilitate, for example, enhanced cell function, arrest cell growth, induced cell death, and tumor size/volume reduction. The identification of safe harbor sites (SHS) has improved outcomes of genome-engineering therapies. Well known SHS include the AAVS1 adeno-associated virus insertion site on chromosome 19, the human homolog of the murine Rosa26 locus, and the CCR5 chemokine receptor gene—the absence of which confers HIV resistance. (See, for example, Pellenz et al., 2018, the relevant disclosures of which are herein incorporated by reference). However, there is still a need for improved guidelines for gene editing therapies and additional SHS to address challenges such as poor knock-in (KI) efficiency, insertional oncogenesis, unstable and/or anomalous expression of transgenes and/or adjacent genes, etc.

SUMMARY

The present disclosure is directed, inter alia, to safe harbor loci that exhibit high knock-in efficiency and stable expression of their transgenes. These safe harbor loci can be used to alter T cells for immunotherapy. These safe harbor loci are useful for the treatment of various diseases, including cancer.

In one aspect, the present disclosure provides an engineered cell, comprising at least one sequence encoding a transgene, wherein the at least one sequence is inserted within a safe harbor locus, the safe harbor locus is at any one or more of the sgRNA target loci provided in Table 4; and wherein expression of the at least one sequence encoding the transgene is operatively linked to an endogenous promoter. In another aspect, the present disclosure provides an engineered cell, comprising at least one sequence encoding a transgene, wherein the at least one sequence is inserted within a safe harbor locus, the safe harbor locus is at any one or more of the sgRNA target loci provided in Table 4; and wherein expression of the at least one sequence encoding the transgene is operatively linked to an exogenous promoter.

In some embodiments, the target locus is selected from: chr10:33130000-33140000, chr10:72290000-72300000, chr11:128340000-128350000, chr11:65425000-65427000 (NEAT1), chr15:92830000-92840000, chr16:11220000-11230000, chr2:87460000-87470000, chr3:186510000-186520000, chr3:59450000-59460000, chr8:127980000-128000000, and chr9:7970000-7980000. In some embodiments, the target locus is selected from: chr10:72290000-72300000, chr11:128340000-128350000, chr15:92830000-92840000, and chr16:11220000-11230000. In some embodiments, the target locus is chr11:128340000-128350000. In some embodiments, the target locus is chr15:92830000-92840000. In some embodiments, the target locus is a gene selected from: APRT, B2M, CAPNS1, CBLB, CD2, CD3E, CD3G, CD5, EDF1, FTL, PTEN, PTPN2, PTPN6, PTPRC, PTPRCAP, RPS23, RTRAF, SERF2, SLC38A1, SMAD2, SOCS1, SRP14, SRSF9, SUB1, TET2, TIGIT, TRAC, and TRIM28.

In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS88, GS89, GS90, GS91, GS92, GS93, GS94, GS95, GS96, GS97, GS98, GS99, GS100, GS101, GS102, GS103, GS104, GS105, GS106, GS107, GS108, GS109, GS110, GS111, GS112, GS113, GS114, GS115, GS116, GS117, GS118, GS119, GS120. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS91, GS92, GS93, GS94, GS95, GS96, GS100, GS101, GS102, GS103, GS104, and GS105. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS103, GS104, and GS105. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS94, GS95, and GS96. In some embodiments, the safe harbor locus is the GS94 integration site in Table 4. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS100, GS101, and GS102. In some embodiments, the safe harbor locus is the GS102 integration site in Table 4. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS91, GS92, and GS93.

In some embodiments, the exogenous promoter is an EF1a promoter. In some embodiments, the engineered cell is a stem cell, a human cell, a primary cell, an hematopoietic cell, an adaptive immune cell, an innate immune cell, a T cell or a T cell progenitor. In some embodiments, the transgene encodes a recombinant protein, optionally a therapeutic agent. In some embodiments, the transgene encodes a chimeric antigen receptor (CAR).

In another aspect, the present disclosure provides a composition comprising the engineered cell as described herein and a pharmaceutical excipient.

In another aspect, the present disclosure provides a guide ribonucleic acids (gRNA) for editing a cell at a safe harbor locus, wherein gRNA comprises any one of the sgRNA sequences in Table 4.

In some embodiments, the gRNA comprises any one of SEQ ID NOS:1-120. In some embodiments, the gRNA comprises any one of SEQ ID NOS: 91-96 and 100-105. In some embodiments, the gRNA comprises SEQ ID NO:94 or SEQ ID NO:102. In some embodiments, the gRNA comprises SEQ ID NO:94. In some embodiments, the gRNA comprises SEQ ID NO:102. In some embodiments, the cell is a stem cell, a human cell, a primary cell, an hematopoietic cell, an adaptive immune cell, an innate immune cell, a T cell or a T cell progenitor.

In another aspect, the present disclosure provides a method of editing a cell having chromosomal DNA, comprising inserting at least one sequence encoding a transgene within a safe harbor locus in the chromosomal DNA of the cell, wherein the safe harbor locus is any one or more of the sgRNA target loci provided in Table 4.

In some embodiments, the transgene encodes a recombinant protein, optionally a therapeutic agent. In some embodiments, the transgene encodes a chimeric antigen receptor (CAR). In some embodiments, the at least one sequence comprises an exogenous promoter and the exogenous promoter is operably linked to the transgene. In some embodiments, the exogenous promoter is an EF1a promoter. In some embodiments, the cell is a stem cell, a human cell, a primary cell, an hematopoietic cell, an adaptive immune cell, an innate immune cell, a T cell or T cell progenitor. In some embodiments, the at least one sequence is inserted using a homology-directed repair. In some embodiments, the at least one sequence is inserted using a homology independent targeted insertion. In some embodiments, the at least one sequence is inserted using one or more guide ribonucleic acids (gRNAs) and one or more Cas9 endonucleases.

In some embodiments, the one or more gRNAs comprises any one of SEQ ID NOS: 1-120. In some embodiments, the one or more gRNAs comprises any one of SEQ ID NOS: 91-96 and 100-105. In some embodiments, the gRNA comprises SEQ ID NO:94 or SEQ ID NO:102. In some embodiments, the gRNA comprises SEQ ID NO:94. In some embodiments, the gRNA comprises SEQ ID NO:102.

In another aspect, the present disclosure provides a method of editing a T cell, comprising contacting a T cell with one or more guide ribonucleic acids (gRNAs), at least one sequence encoding a transgene, and one or more Cas9 endonucleases, wherein the one or more gRNAs and Cas9 endonucleases facilitate the insertion of the at least one sequence into chromosomal DNA within a safe harbor locus, wherein the safe harbor locus is selected from any one or more of the sgRNA target loci in Table 4.

In some embodiments, the one or more gRNAs comprises a sequence selected from any one of the sgRNA sequences in Table 4. In some embodiments, the one or more gRNAs comprises any one of SEQ ID NOS: 1-120. In some embodiments, the one or more gRNAs comprises any one of SEQ ID NOS: 91-96 and 100-105. In some embodiments, the gRNA comprises SEQ ID NO:94 or SEQ ID NO:102. In some embodiments, the gRNA comprises SEQ ID NO:94. In some embodiments, the gRNA comprises SEQ ID NO:102.

In another aspect, the present disclosure provides an ex vivo method of obtaining an engineered cell or population thereof, comprising (a) obtaining a cell; and (b) genetically modifying the cell by inserting at least one sequence encoding a transgene within a safe harbor locus, wherein the safe harbor locus is selected from any one of the sgRNA target loci in Table 4.

In some embodiments, obtaining the cell comprises: (i) collecting a tissue sample from a subject, (ii) isolating the cells from the tissue samples, and (iii) culturing the cells in vitro. In some embodiments, the tissue sample is a blood sample. In some embodiments, the cell is a stem cell, a human cell, a primary cell, an hematopoietic cell, an adaptive immune cell, an innate immune cell, a T cell or T cell precursor. In some embodiments, the at least one sequence is inserted using a homology-directed repair. In some embodiments, the at least one sequence is inserted using a homology independent targeted insertion.

In some embodiments, the genetically modifying in step (b) comprises contacting the cell with one or more guide ribonucleic acids (gRNAs), the at least one sequence, and one or more Cas9 endonucleases, wherein the one or more gRNAs and Cas9 endonucleases facilitate the insertion of the at least one sequence into chromosomal DNA within the safe harbor locus. In some embodiments, the one or more gRNAs comprises a sequence selected from any one of the sgRNA sequences in Table 4.

In yet another aspect, the present disclosure provides a method of treating a subject having or at risk of having a disease, comprising administering to the subject an effective amount of an engineered cell as described herein, a population thereof, or a composition as described herein. In some embodiments, the cell, the population thereof, or the composition is administered to the subject by infusion.

In yet another aspect, the present disclosure provides a method of treating a subject having or at risk of having a disease, comprising (a) conducting any one of the methods described supra; and (b) administering to the subject an effective amount of a composition comprising the cell or a population thereof. In some embodiments, the composition is administered to the subject by infusion. In some embodiments, the disease is cancer. In some embodiments, the disease is blood cancer.

In another aspect, the present disclosure provides a method of identifying a safe harbor locus, comprising: (a) identifying genes or non-coding regions in a chromosome that are above a threshold level for expression across developmental cell states and/or a threshold level for accessibility of chromatin; (b) generating a linear model that correlates the gene or non-coding region from step (a) with knock-in (KI) efficiency and estimates the KI efficiency of any gene or coding region on the chromosome; and (c) selecting the safe harbor locus based on threshold parameters; wherein the safe harbor locus is selected for insertion of at least one sequence encoding a transgene within a cell.

In some embodiments, the threshold parameters include one or more of: stable expression of a transgene, knockout of the gene confers benefit to the function of the cell, no known function within the cell, stable transgene expression in vitro with or without CD3/CD28 stimulation, negligible off-target cleavage as detected by iGuide-Seq or CRISPR-Seq, less off-target cleavage relative to other loci as detected by iGuide-Seq or CRISPR-Seq, negligible transgene-independent cytotoxicity, negligible transgene-independent cytokine expression, negligible transgene-independent chimeric antigen receptor expression, negligible deregulation or silencing of nearby genes, and positioned outside of a cancer-related gene. In some embodiments, the stable expression of a transgene at the safe harbor locus is less than or equal to 2-fold expression change over the course of at least 1, 2, 3, 4, 5, 6, or 7 days, and wherein expression change is measured by mean fluorescence intensity of a reporter gene encoded by the at least one sequence. In some embodiments, the accessibility of chromatin is measured using an assay for transposase-accessible chromatin using sequencing (ATAC-seq). In some embodiments, the level of expression across developmental cell states is measured using RNA sequencing (RNA-seq).

In some embodiments, the cell is a stem cell, a human cell, a primary cell, an hematopoietic cell, an adaptive immune cell, an innate immune cell, a T cell or T cell precursor. In some embodiments, the linear model has a coefficient of determination (R²value) of at least 30%.

In yet another aspect, the present disclosure provides an engineered cell, composition, gRNA or method as described herein, wherein insertion within the safe harbor locus increase cell cytotoxicity of diseased cells.

In yet another aspect, the present disclosure provides an engineered cell, composition, gRNA or method as described herein, wherein knock-in efficiency at the safe harbor locus is increased relative to other locations along the chromosome.

BRIEF DESCRIPTION OF THE DRAWINGS

These and other features, aspects, and advantages of the present invention will become better understood with regard to the following description, and accompanying drawings, where:

FIG. 1 includes a schematic depicting the methodology used to identify safe harbor loci in the present disclosure, in some embodiments.

FIGS. 2A-2C include schematic depicting 3 top safe harbor loci known in the art: AAVS1 (FIG. 2A), CCR5 (FIG. 2B), and Rosa26 (FIG. 2C). The figures were retrieved from Sadelain, M., et al. (2012). Safe harbours for the integration of new DNA in the human genome. Nature reviews Cancer, 12(1), 51-58, the relevant disclosures of which are herein incorporated by reference in their entirety.

FIG. 3 includes a schematic outlining the data provided in Roth, T. L., et al. 2019. Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits. bioRxiv, 604561, the relevant disclosures of which are herein incorporated by reference in their entirety.

FIGS. 4A-4B include heatmaps with samples clustered based on activation status and cell type, generated with processed RNA-seq data. FIG. 4A includes a heatmap of samples generated with processed RNA-seq data. FIG. 4B includes a heatmap sample generated with processed RNA-seq data, showing the clustering of ˜20 k genes.

FIGS. 5A-5B include plots generated using processed RNA-seq data. FIG. 5A includes a plot showing direct correlation between transcript expression data from Roth, T. L., et al. 2019 and transcript expression data generated by the inventors of the present disclosure. FIG. 5B includes a heatmap showing clusters of the top 10% expressed genes.

FIG. 6 includes a heatmap of samples generated with processed ATAC-seq data.

FIGS. 7A-7B includes plots depicting the signal enrichment at transcription start sites (TSS) (FIG. 7A) and peak size distribution (FIG. 7B), generated with processed ATAC-seq data for coding regions.

FIG. 8 includes a plot depicting the open chromatin regions around the TRAC locus.

FIG. 9 includes a plot depicting KI (knock-in) efficiency for coding regions/genes with GFP as a reporter.

FIG. 10 includes a plot depicting KI efficiency for coding regions/genes with tNGFR as a reporter.

FIG. 11 includes plots showing scaled KI efficiency for 90 genes vs d2 (day-2) RNA-seq data, d4 (day-4) RNA-seq data and ATAC-seq data, utilized for the predictive linear model.

FIG. 12 includes a plot showing chromatin accessibility for a top candidate non-coding region, measured using ATAQ sequencing.

FIG. 13A includes plots showing the cell counts for GFP controls used for the evaluation of candidate KI loci. FIG. 13B includes pmax (GFP_high) readings for GFP controls used for the evaluation of candidate KI loci.

FIG. 14A includes plots showing the maximum episomal GFP expression (GFP_high) readings for non-targeting controls. FIG. 14B includes the cell count for non-targeting controls from donors 1, 2, and 3.

FIG. 15 includes the cell count and maximum GFP expression (GFP_high) readings for WT controls.

FIG. 16 includes plots showing the cell count and maximum GFP expression (GFP_high) readings when using sgRNA5, which targets a B2M safe harbor locus, and the construct expression was driven by an endogenous promoter.

FIG. 17 includes plots showing the cell count and maximum GFP expression (GFP_high) readings when using sgRNA5, which targets a B2M safe harbor locus, and the construct expression was driven by an EF1a promoter.

FIG. 18 includes plots showing the cell count and maximum GFP expression (GFP_high) readings when using sgRNA79 to target a TRAC safe harbor locus, and the construct expression was driven by an endogenous promoter.

FIG. 19 includes plots showing the cell count and maximum GFP expression (GFP_high) readings when using sgRNA79, which targets a TRAC safe harbor locus, and the construct expression was driven by an exogenous promoter.

FIG. 20 includes plots showing TCR (T cell receptor) vs. GFP among all donors and time points when using sgRNA79, and the construct is driven by an endogenous promoter.

FIG. 21 includes plots showing TCR vs. GFP among all donors and time points when using sgRNA79 and the construct is driven by an exogenous promoter.

FIG. 22 includes plots showing the cell count and maximum GFP expression (GFP_high) readings when using sgRNA83, which targets a TRAC safe harbor locus, and the construct expression was driven by an endogenous promoter.

FIG. 23 includes plots showing the cell count and maximum GFP expression (GFP_high) readings when using sgRNA83, which targets a TRAC safe harbor locus, and the construct expression was driven by an exogenous promoter.

FIG. 24 includes plots showing TCR vs. GFP among all donors and time points when using sgRNA83 and the construct is driven by an endogenous promoter.

FIG. 25 includes plots showing TCR vs. GFP among all donors and time points when using sgRNA83 and the construct is driven by an exogenous promoter.

FIG. 26 includes plots illustrating potential sources of variation (e.g., edge effects and electroporation errors) observed between replicates and donors.

FIG. 27 includes plots illustrating potential sources of variation observed between replicates and donors, e.g., relating to inherent differences between donors.

FIG. 28 includes plots illustrating potential sources of variation observed between replicates and donors, e.g., relating to gating errors.

FIG. 29 includes plots showing the GFP mean fluorescence intensity (GFP MFI) and KI efficiency for top KI loci evaluated with endogenous promoters.

FIG. 30 includes plots showing the GFP mean fluorescence intensity (GFP MFI) and KI efficiency for top KI loci evaluated with the EF1a promoter.

FIGS. 31A-31C include plots showing all the significant KI loci (top KI loci) as evaluated with endogenous and EF1a promoters. FIG. 31A includes a plot showing that the expression from the EF1a promoter was approximately 10 times higher than expression from an endogenous promoter. FIG. 31B shows the top KI loci ranked by GFP MFI at week 3. FIG. 31C shows the top integration loci ranked by GFP MFI (at weeks 3 and 4; donors 1-3).

FIG. 32A includes a plot showing some target loci and their measured transgene expression levels. FIG. 32B includes plots showing the transgene (Prime Receptor (PrimeR)) and TCR expression for the control and insertion at GS94, GS102 and TRAC loci.

FIG. 33A includes a plot showing the PrimeR levels measured for the indicated integration sites. FIG. 33B includes a schematic showing the GS94 integration site on Chromosome 11.

FIG. 34A includes plots showing CAR induction and primeR expression of engineered T cells after 48 hours of coculturing with K562-CD19 cells. FIG. 34B includes plots showing the cytotoxity and cytokine secretion levels for engineered T cells 48 hours of coculturing with K562-CD19/MSLN cells.

FIG. 35A includes a schematic showing the experimental overview for evaluating the effect of integration site on cytotoxicity. FIG. 35B includes plots showing the measured cytotoxicity for engineered T cells cocultured for 48 hours with the K562 CD19+/MSLN+ or K562 CD19−/MSLN+ cells.

FIG. 36A includes a schematic showing the experimental overview for evaluating the effect of integration site on cytokine secretion. FIG. 36B includes plots showing the measured cytokine levels for engineered T cells cocultured for 48 hours with K562 CD19+/MSLN+ cells.

FIG. 37 includes a schematic showing the in vitro experiment conducted to determin the effect of integration site on primeR-independent CAR expression. “Flow” refers to flow cytometry and “restim” refers to repetitive CD3/CD28 stimulation of the engineered T cells. “EP” refers to electroporation.

FIGS. 38A and 38B include plots showing the stability of PrimeR expression over time when using the indicated integration sites. “Flow” refers to flow cytometry and “restim” refers to repetitive CD3/CD28 stimualation of the engineered T cells. “EP” refers to electroporation. In FIG. 38B, the PrimeR expression is normalized to the expression from using the TRAC integration site.

FIG. 39A includes a schematic showing the iGuide-Seq assay technique. FIG. 39B includes a plot showing the on-target efficiency, using iGuide Seq assay, for the indicated integration sites. FIG. 39C includes schematics from the iGuide-Seq analysis showing that GS94 had no reproducible putatitve off-targets across two donors FIG. 39C discloses SEQ ID NOS 312-322, 312-313, and 323-331, respectively, in order of appearance.

FIG. 40 includes a schematic showing the iGuide-Seq workflow and data.

FIG. 41 includes a plot showing rhAmp-seg™ analysis of putative off-target sites identified by iGUIDE-seq and Elevation prediction.

FIG. 42 includes plots showing RNA-seq analysis of cells with GS94, GS102 and TRAC knock-in of CD19/MSLN circuits. Scatterplot of gene expression in cells with integration at the GS94 locus (y-axis) vs cells with integration at either the TRAC or the GS102 locus (x-axis) in two donors. The yellow dots correspond to ETS1 and FLI1. In blue are the genes that were found to be differentially expressed using edgeR (fold-change >0, FDR-corrected p-value <0.01, average counts-per-million across compared conditions at least 2).

FIG. 43 includes plots showing the absence of cytokine-independent growth in cells with CD19/MSLN circuit KI at GS94.

DETAILED DESCRIPTION

The present disclosure provides safe harbor loci and methods for identifying safe harbor loci that exhibit high integration efficiency (e.g., high knock-in (KI) efficiency), high and constant levels of transgene expression, and such benefits independent of T cell activation/differentiation state. In some embodiments, the safe harbor loci also exhibit minimal to no disruption to T cell function and/or capacity for product manufacturing. In some embodiments, these loci are useful for effective and safe integration and expression of transgenes in T cells (e.g. in CAR T therapies). In some embodiments, the methods described herein can be used for the identification of safe harbor loci for insertion of transgenes in other types of cells.

FIG. 1 illustrates the overall approach that the inventors of the present disclosure used to identify safe harbor loci. In some embodiments, the present disclosure provides a method comprising the identification of genes within a genome and non-coding regions with sustained expression in a treatment cell (e.g. T cell) and using a predictive model of KI efficiency as a function of T cell chromatic state and computational analysis to predict candidate integration sites. The method further comprises evaluating the candidate integration sites for actual KI efficiency, sustained levels of transgene expression of a transgene, and minimal disruption to the treatment cell phenotype (e.g., T cell function and/or capacity for treatment product expansion and manufacturing). In some embodiments, the safe harbor loci allow for integration of a transgene driven by an endogenous promoter. In some embodiments, the safe harbor loci allow for integration of a transgene driven by an exogenous promoter (e.g. EF1a promoter).

To facilitate an understanding of the present disclosure, a number of terms and phrases are defined below. Unless otherwise defined herein, scientific and technical terms used in this application shall have the meanings that are commonly understood by those of ordinary skill in the art. Generally, nomenclature used in connection with, and techniques of pharmacology, cell and tissue culture, molecular biology, cell and cancer biology, neurobiology, neurochemistry, virology, immunology, microbiology, genetics and protein and nucleic acid chemistry, described herein, are those well-known and commonly used in the art. In case of conflict, the present specification, including definitions, will control.

Unless otherwise defined, all terms of art, notations and other scientific terminology used herein are intended to have the meanings commonly understood by those of skill in the art. In some cases, terms with commonly understood meanings are defined herein for clarity and/or for ready reference, and the inclusion of such definitions herein should not necessarily be construed to represent a difference over what is generally understood in the art. The techniques and procedures described or referenced herein are generally well understood and commonly employed using conventional methodologies by those skilled in the art, such as, for example, the widely utilized molecular cloning methodologies described in Sambrook et al., Molecular Cloning: A Laboratory Manual 4th ed. (2012) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. As appropriate, procedures involving the use of commercially available kits and reagents are generally carried out in accordance with manufacturer-defined protocols and conditions unless otherwise noted.

As used herein, the singular forms “a,” “an,” and “the” include the plural referents unless the context clearly indicates otherwise. The terms “include,” “such as,” and the like are intended to convey inclusion without limitation, unless otherwise specifically indicated.

As used herein, the term “comprising” also specifically includes embodiments “consisting of” and “consisting essentially of” the recited elements, unless specifically indicated otherwise.

The term “about” indicates and encompasses an indicated value and a range above and below that value. In certain embodiments, the term “about” indicates the designated value ±10%, ±5%, or ±1%. In certain embodiments, where applicable, the term “about” indicates the designated value(s) ±one standard deviation of that value(s).

As used herein, the term “gene” refers to the basic unit of heredity, consisting of a segment of DNA arranged along a chromosome, which codes for a specific protein or segment of protein. A gene typically includes a promoter, a 5′ untranslated region, one or more coding sequences (exons), optionally introns, a 3′ untranslated region. The gene may further comprise a terminator, enhancers and/or silencers.

As used herein, the term “locus” refers to a specific, fixed physical location on a chromosome where a gene or genetic marker is located.

As used herein, the term “target locus” refers to a locus on a chromosome within which a safe harbor locus can be used for the insertion of a sequence. A target locus can consist of multiple potential safe harbor loci (integration sites). Examples of target loci are provided in Table 4, as sgRNA target loci. The notation used for the sgRNA target loci in Table 4 refers to the genomic region of the target locus, defined by the chromosome of the target locus and the coordinate range for that target locus. For example, chr10:33130000-33140000 refers to a target locus on Chr10 (chromosome 10) starting from coordinate 33130000 and ending with coordinate 33140000.

The term “safe harbor locus” refers to a locus at which genes or genetic elements can be incorporated without disruption to expression or regulation of adjacent genes. These safe harbor loci are also referred to as safe harbor sites (SHS). As used herein, a safe harbor locus refers to an “integration site” or “knock-in site” at which a sequence encoding a transgene, as defined herein, can be inserted. In some embodiments the insertion occurs with replacement of a sequence that is located at the integration site. In some embodiments, the insertion occurs without replacement of a sequence at the integration site. Examples of integration sites contemplated are provided in Table 4.

As used herein, the term “insert” refers to a nucleotide sequence that is integrated (inserted) at a safe harbor site. The insert can be used to refer to the genes or genetic elements that are incorporated at the safe harbor site using, for example, homology-directed repair (HDR) CRISPR/Cas9 genome-editing or other methods for inserting nucleotide sequences into a genomic region known to those of ordinary skill in the art.

The “CRISPR/Cas” system refers to a widespread class of bacterial systems for defense against foreign nucleic acid. CRISPR/Cas systems are found in a wide range of eubacterial and archaeal organisms. CRISPR/Cas systems include type I, II, and III sub-types. Wild-type type II CRISPR/Cas systems utilize an RNA-mediated nuclease, Cas9 in complex with guide and activating RNA to recognize and cleave foreign nucleic acid. Guide RNAs having the activity of both a guide RNA and an activating RNA are also known in the art. In some cases, such dual activity guide RNAs are referred to as a small guide RNA (sgRNA).

Cas9 homologs are found in a wide variety of eubacteria, including, but not limited to bacteria of the following taxonomic groups: Actinobacteria, Aquificae, Bacteroidetes-Chlorobi, Chlamydiae-Verrucomicrobia, Chlroflexi, Cyanobacteria, Firmicutes, Proteobacteria, Spirochaetes, and Thermotogae. An exemplary Cas9 protein is the Streptococcus pyogenes Cas9 protein. Additional Cas9 proteins and homologs thereof are described in, e.g., Chylinksi, et al., RNA Biol. 2013 May 1; 10(5): 726-737; Nat. Rev. Microbiol. 2011 June; 9(6): 467-477; Hou, et al., Proc Natl Acad Sci USA. 2013 Sep. 24; 110(39):15644-9; Sampson et al., Nature. 2013 May 9; 497(7448):254-7; and Jinek, et al., Science. 2012 Aug. 17; 337(6096):816-21. The Cas9 nuclease domain can be optimized for efficient activity or enhanced stability in the host cell.

As used herein, the term “Cas9” refers to an RNA-mediated nuclease (e.g., of bacterial or archeal orgin, or derived therefrom). Exemplary RNA-mediated nuclases include the foregoing Cas9 proteins and homologs thereof, and include but are not limited to, CPF1 (See, e.g., Zetsche et al., Cell, Volume 163, Issue 3, p 759-771, 22 Oct. 2015). Similarly, as used herein, the term “Cas9 ribonucleoprotein” complex and the like refers to a complex between the Cas9 protein, and a crRNA (e.g., guide RNA or small guide RNA), the Cas9 protein and a trans-activating crRNA (tracrRNA), the Cas9 protein and a small guide RNA, or a combination thereof (e.g., a complex containing the Cas9 protein, a tracrRNA, and a crRNA guide RNA).

As used herein, the terms “T lymphocyte” and “T cell” are used interchangeably and refer to cells that have completed maturation in the thymus, and identify certain foreign antigens in the body. The terms also refer to the major leukocyte types that have various roles in the immune system, including activation and deactivation of other immune cells. The T cell can be any T cell such as a cultured T cell, e.g., a primary T cell, or a T cell derived from a cultured T cell line, e.g., a Jurkat, SupT1, etc., or a T cell obtained from a mammal. The T cell can be a CD3+ cell. The T cell can be any type of T cell, CD4+/CD8+ double positive T cells, CD4+ helper T cells (e.g. Th1 and Th2 cells), CD8+ T cells (e.g. cytotoxic T cells), peripheral Including but not limited to blood mononuclear cells (PBMC), peripheral blood leukocytes (PBL), tumor infiltrating lymphocytes (TIL), memory T cells, naive T cells, regulatory T cells, γδ T cells, etc. It can be any T cell at any stage of development. Additional types of helper T cells include Th3 (Treg) cells, Th17 cells, Th9 cells, or Tfh cells. Additional types of memory T cells include cells such as central memory T cells (Tcm cells), effector memory T cells (Tem cells and TEMRA cells). A T cell can also refer to a genetically modified T cell, such as a T cell that has been modified to express a T cell receptor (TCR) or a chimeric antigen receptor (CAR). T cells can also be differentiated from stem cells or progenitor cells.

“CD4+ T cells” refers to a subset of T cells that express CD4 on their surface and are associated with a cellular immune response. CD4+ T cells are characterized by a post-stimulation secretion profile that can include secretion of cytokines such as IFN-γ, TNF-α, IL-2, IL-4 and IL-10. “CD4” is a 55 kD glycoprotein originally defined as a differentiation antigen on T lymphocytes, but was also found on other cells including monocytes/macrophages. The CD4 antigen is a member of the immunoglobulin superfamily and has been implicated as an associative recognition element in MHC (major histocompatibility complex) class II restricted immune responses. On T lymphocytes, the CD4 antigen defines a helper/inducer subset.

“CD8+ T cells” refers to a subset of T cells that express CD8 on their surface, are MHC class I restricted, and function as cytotoxic T cells. The “CD8” molecule is a differentiation antigen present on thymocytes, as well as on cytotoxic and suppressor T lymphocytes. The CD8 antigen is a member of the immunoglobulin superfamily and is an associative recognition element in major histocompatibility complex class I restriction interactions.

As used herein, the term “ex vivo” generally includes experiments or measurements made in or on living tissue, preferably in an artificial environment outside the organism, preferably with minimal differences from natural conditions.

As used herein, the term “construct” refers to a complex of molecules, including macromolecules or polynucleotides.

As used herein, the term “integration” refers to the process of stably inserting one or more nucleotides of a construct into the cell genome, i.e., covalently linking to a nucleic acid sequence in the chromosomal DNA of the cell. It may also refer to nucleotide deletions at a site of integration. Where there is a deletion at the insertion site, “integration” may further include substitution of the endogenous sequence or nucleotide deleted with one or more inserted nucleotides.

As used herein, the term “exogenous” refers to a molecule or activity that has been introduced into a host cell and is not native to that cell. The molecule can be introduced, for example, by introduction of the encoding nucleic acid into host genetic material, such as by integration into a host chromosome, or as non-chromosomal genetic material, such as a plasmid. Thus, the term, when used in connection with expression of an encoding nucleic acid, refers to the introduction of the encoding nucleic acid into a cell in an expressible form. The term “endogenous” refers to a molecule or activity that is present in a host cell under natural, unedited conditions. Similarly, the term, when used in connection with expression of the encoding nucleic acid, refers to expression of the encoding nucleic acid that is contained within the cell and not introduced exogenously.

As used herein, a “polynucleotide donor construct” refers to a nucleotide sequence (e.g. DNA sequence) that is genetically inserted into a polynucleotide and is exogenous to that polynucleotide. The polynucleotide donor construct is transcribed into RNA and optionally translated into a polypeptide. The polynucleotide donor construct can include prokaryotic sequences, cDNA from eukaryotic mRNA, genomic DNA sequences from eukaryotic (e.g., mammalian) DNA, and synthetic DNA sequences. For example, the polynucleotide donor construct can be a miRNA, shRNA, natural polypeptide (i.e., a naturally occurring polypeptide) or fragment thereof or a variant polypeptide (e.g. a natural polypeptide having less than 100% sequence identity with the natural polypeptide) or fragments thereof.

As used herein, the term “transgene” refers to a polynucleotide that has been transferred naturally, or by any of a number of genetic engineering techniques from one organism to another. It is optionally translated into a polypeptide. It is optionally translated into a recombinant protein. A “recombinant protein” is a protein encoded by a gene—recombinant DNA—that has been cloned in a system that supports expression of the gene and translation of messenger RNA (see expression system). The recombinant protein can be a therapeutic agent, e.g. a protein that treats a disease or disorder disclosed herein. As used, transgene can refer to a polynucleotide that encodes a polypeptide. A transgene can also refer to a non-encoding sequence, such as, but not limited to shRNAs, miRNAs, and miRs.

The terms “protein,” “polypeptide,” and “peptide” are used herein interchangeably.

As used herein, the term “operably linked” refers to the binding of a nucleic acid sequence to a single nucleic acid fragment such that one function is affected by the other. For example, if a promoter is capable of affecting the expression of a coding sequence or functional RNA (i.e., the coding sequence or functional RNA is under transcriptional control by the promoter), the promoter is operably linked thereto. Coding sequences can be operably linked to control sequences in both sense and antisense orientation.

As used herein, the term “developmental cell states” refers to, for example, states when the cell is inactive, actively expressing, differentiating, senescent, etc. developmental cell state may also refer to a cell in a precursor state (e.g., a T cell precursor).

As used, the term “encoding” refers to a sequence of nucleic acids which codes for a protein or polypeptide of interest. The nucleic acid sequence may be either a molecule of DNA or RNA. In preferred embodiments, the molecule is a DNA molecule. In other preferred embodiments, the molecule is a RNA molecule. When present as a RNA molecule, it will comprise sequences which direct the ribosomes of the host cell to start translation (e.g., a start codon, ATG) and direct the ribosomes to end translation (e.g., a stop codon). Between the start codon and stop codon is an open reading frame (ORF). Such terms are known to one of ordinary skill in the art.

The term “inserting” refers to a manipulation of a nucleotide sequence to introduce a non-native sequence. This is done, for example, via the use of restriction enzymes and ligases whereby the DNA sequence of interest, usually encoding the gene of interest, can be incorporated into another nucleic acid molecule by digesting both molecules with appropriate restriction enzymes in order to create compatible overlaps and then using a ligase to join the molecules together. One skilled in the art is very familiar with such manipulations and examples may be found in Sambrook et al. (Sambrook, Fritsch, & Maniatis, “Molecular Cloning: A Laboratory Manual”, 2nd ed., Cold Spring Harbor Laboratory, 1989), which is hereby incorporated by reference in its entirety including any drawings, figures and tables.

As used herein, the term “subject” refers to a mammalian subject. Exemplary subjects include humans, monkeys, dogs, cats, mice, rats, cows, horses, camels, goats, rabbits, pigs and sheep. In certain embodiments, the subject is a human. In some embodiments the subject has a disease or condition that can be treated with an engineered cell provided herein or population thereof. In some aspects, the disease or condition is a cancer.

As used herein, the term “promoter” refers to a nucleotide sequence (e.g. DNA sequence) capable of controlling the expression of a coding sequence or functional RNA. The promoter sequence consists of proximal and more distal upstream elements, the latter elements often referred to as enhancers. A promoter can be derived from natural genes in its entirety, can be composed of different elements from different promoters found in nature, and/or may comprise synthetic DNA segments. A promoter, as contemplated herein, can be endogenous to the cell of interest or exogenous to the cell of interest. It is appreciated by those skilled in the art that different promoters can induce gene expression in different tissue or cell types, or at different developmental stages, or in response to different environmental conditions. As is known in the art, a promoter can be selected according to the strength of the promoter and/or the conditions under which the promoter is active, e.g., constitutive promoter, strong promoter, weak promoter, inducible/repressible promoter, tissue specific Or developmentally regulated promoters, cell cycle-dependent promoters, and the like.

A promoter can be an inducible promoter (e.g., a heat shock promoter, tetracycline-regulated promoter, steroid-regulated promoter, metal-regulated promoter, estrogen receptor-regulated promoter, etc.). The promoter can be a constitutive promoter (e.g., CMV promoter, UBC promoter). In some embodiments, the promoter can be a spatially restricted and/or temporally restricted promoter (e.g., a tissue specific promoter, a cell type specific promoter, etc.). See for example U.S. application Ser. No. 15/715,068, the disclosures of which are herein incorporated by reference in their entirety.

Gene editing, as contemplated herein, may involve a gene (or nucleotide sequence) knock-in or knock-out. As used herein, the term “knock-in” refers to an addition of a DNA sequence, or fragment thereof into a genome. Such DNA sequences to be knocked-in may include an entire gene or genes, may include regulatory sequences associated with a gene or any portion or fragment of the foregoing. For example, a polynucleotide donor construct encoding a recombinant protein may be inserted into the genome of a cell carrying a mutant gene. In some embodiments, a knock-in strategy involves substitution of an existing sequence with the provided sequence, e.g., substitution of a mutant allele with a wild-type copy. On the other hand, the term “knock-out” refers to the elimination of a gene or the expression of a gene. For example, a gene can be knocked out by either a deletion or an addition of a nucleotide sequence that leads to a disruption of the reading frame. As another example, a gene may be knocked out by replacing a part of the gene with an irrelevant (e.g., non-coding) sequence.

As used herein, the term “non-homologous end joining” or NHEJ refers to a cellular process in which cut or nicked ends of a DNA strand are directly ligated without the need for a homologous template nucleic acid. NHEJ can lead to the addition, the deletion, substitution, or a combination thereof, of one or more nucleotides at the repair site.

As used herein, the term “homology directed repair” or HDR refers to a cellular process in which cut or nicked ends of a DNA strand are repaired by polymerization from a homologous template nucleic acid. Thus, the original sequence is replaced with the sequence of the template. The homologous template nucleic acid can be provided by homologous sequences elsewhere in the genome (sister chromatids, homologous chromosomes, or repeated regions on the same or different chromosomes). Alternatively, an exogenous template nucleic acid can be introduced to obtain a specific HDR-induced change of the sequence at the target site. In this way, specific mutations can be introduced at the cut site.

The terms “vector” and “plasmid” are used interchangeably and as used herein refer to polynucleotide vehicles useful to introduce genetic material into a cell. Vectors can be linear or circular. Vectors can integrate into a target genome of a host cell or replicate independently in a host cell. Vectors can comprise, for example, an origin of replication, a multicloning site, and/or a selectable marker. An expression vector typically comprises an expression cassette. Vectors and plasmids include, but are not limited to, integrating vectors, prokaryotic plasmids, eukaryotic plasmids, plant synthetic chromosomes, episomes, viral vectors, cosmids, and artificial chromosomes.

As used herein the term “expression cassette” is a polynucleotide construct, generated recombinantly or synthetically, comprising regulatory sequences operably linked to a selected polynucleotide to facilitate expression of the selected polynucleotide in a host cell. For example, the regulatory sequences can facilitate transcription of the selected polynucleotide in a host cell, or transcription and translation of the selected polynucleotide in a host cell. An expression cassette can, for example, be integrated in the genome of a host cell or be present in an expression vector.

As used herein, the phrase “subject in need thereof” refers to a subject that exhibits and/or is diagnosed with one or more symptoms or signs of a disease or disorder as described herein.

A “chemotherapeutic agent” refers to a chemical compound useful in the treatment of cancer. Chemotherapeutic agents include “anti-hormonal agents” or “endocrine therapeutics” which act to regulate, reduce, block, or inhibit the effects of hormones that can promote the growth of cancer.

The term “composition” refers to a mixture that contains, e.g., an engineered cell or protein contemplated herein. In some embodiments, the composition may contain additional components, such as adjuvants, stabilizers, excipients, and the like. The term “composition” or “pharmaceutical composition” refers to a preparation which is in such form as to permit the biological activity of an active ingredient contained therein to be effective in treating a subject, and which contains no additional components which are unacceptably toxic to the subject in the amounts provided in the pharmaceutical composition.

As used herein, the term “effective amount” refers to the amount of a compound (e.g., a compositions described herein, cells described herein) sufficient to effect beneficial or desired results. An effective amount can be administered in one or more administrations, applications or dosages and is not intended to be limited to a particular formulation or administration route. As used herein, the term “treating” includes any effect, e.g., lessening, reducing, modulating, ameliorating or eliminating, that results in the improvement of the condition, disease, disorder, and the like, or ameliorating a symptom thereof.

The terms “modulate” and “modulation” refer to reducing or inhibiting or, alternatively, activating or increasing, a recited variable.

The terms “increase” and “activate” refer to an increase of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 100%, 2-fold, 3-fold, 4-fold, 5-fold, 10-fold, 50-fold, 100-fold, or greater in a recited variable.

The terms “reduce” and “inhibit” refer to a decrease of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 2-fold, 3-fold, 4-fold, 5-fold, 10-fold, 20-fold, 100-fold, or greater in a recited variable.

1. Safe Harbor Loci

Gene editing therapies include, for example, viral vector integration and site specific integration. Site-specific integration is a promising alternative to random integration of viral vectors, as it mitigates the risks of insertional mutagenesis or insertional oncogenesis (Kolb et al. Trends Biotechnol. 2005 23:399-406; Porteus et al. Nat Biotechnol. 2005 23:967-973; Paques et al. Curr Gen Ther. 2007 7:49-66). However, site specific integration continues to face challenges such as poor knock-in efficiency, risk of insertional oncogenesis, unstable and/or anomalous expression of adjacent genes or the transgene, low accessibility (e.g. within kB of adjacent genes), etc. These challenges can be addressed, in part, through the identification and use of safe harbor loci or safe harbor sites (SHS), which are sites in which genes or genetic elements can be incorporated without disruption to expression or regulation of adjacent genes.

The most widely used of the putative human safe harbor sites is the AAVS1 site on chromosome 19q, which was initially identified as a site for recurrent adenoassociated virus insertion. Other potential SHS have been identified on the basis of homology, with sites first identified in other species (e.g., the human homolog of the permissive murine Rosa26 locus) or among the growing number of human genes that appear non-essential under some circumstances. One putative SHS of this type is the CCR5 chemokine receptor gene, which, when disrupted, confers resistance to human immunodeficiency virus infection. Additional potential genomic SHS have been identified in human and other cell types on the basis of viral integration site mapping or gene-trap analyses, as was the original murine Rosa26 locus. The three top SHS, AAVS1, CCR5, and Rosa26, are in close proximity to many protein coding genes and regulatory elements. (See FIG. 2 from Sadelain, M., et al. (2012). Safe harbours for the integration of new DNA in the human genome. Nature reviews Cancer, 12(1), 51-58, the relevant disclosures of which are herein incorporated by reference in their entirety).

The AAVS1 (also known as the PPP 1R12C locus) on human chromosome 19 is a known SHS for hosting transgenes (e.g. DNA transgenes) with expected function. It is at position 19q13.42. It has an open chromatin structure and is transcription-competent. The canonical SHS locus for AAVS1 is chr19: 55,625,241-55,629,351. See Pellenz et al. “New Human Chromosomal Sites with “Safe Harbor” Potential for Targeted Transgene Insertion.” Human gene therapy vol. 30,7 (2019): 814-828, the relevant disclosures of which are herein incorporated by reference. An exemplary AAVS1 target gRNA and target sequence are provided below:

AAVS1-gRNA sequence:

(SEQ ID NO: 121)

ggggccactagggacaggatGTTTTAGAGCTAGAA

ATAGCAAGTTAAAATAAGGCTAGTCCGTTATCAAC

TTGAAAAAGTGGCACCGAGTCGGTGCTTTTTTT

AAVS1 target sequence:

(SEQ ID NO: 122)

ggggccactagggacaggat

CCR5, which is located on chromosome 3 at position 3p21.31, encodes the major co-receptor for HIV-1. Disruption at this site in the CCR5 gene has been beneficial in HIV/AIDS therapy and prompted the development of zinc-finger nucleases that target its third exon. The canonical SHS locus for CCR5 is chr3: 46,414,443-46,414,942. See Pellenz et al. “New Human Chromosomal Sites with “Safe Harbor” Potential for Targeted Transgene Insertion.” Human gene therapy vol. 30,7 (2019): 814-828, the relevant disclosures of which are herein incorporated by reference.

The mouse Rosa26 locus is particularly useful for genetic modification as it can be targeted with high efficiency and is expressed in most cell types tested. Irion et al. 2007 (“Identification and targeting of the ROSA26 locus in human embryonic stem cells.” Nature biotechnology 25.12 (2007): 1477-1482, the relevant disclosure of which are herein incorporated by reference) identified the human homolog, human ROSA26, in chromosome 3 (position 3p25.3). The canonical SHS locus for human Rosa26 (hRosa26) is chr3: 9,415,082-9,414,043. See Pellenz et al. “New Human Chromosomal Sites with “Safe Harbor” Potential for Targeted Transgene Insertion.” Human gene therapy vol. 30,7 (2019): 814-828, the relevant disclosures of which are herein incorporated by reference.

Additional examples of safe harbor sites are provided in Pellenz et al. “New Human Chromosomal Sites with “Safe Harbor” Potential for Targeted Transgene Insertion.” Human gene therapy vol. 30,7 (2019): 814-828, the relevant disclosures of which are herein incorporated by reference.

The present disclosure is directed to methods for identifying safe harbor loci with benefits including, but not limited to, high knock-in efficiency and high expression of transgene. An example of applications of the presently disclosed methods is the identification of safe harbor loci for insertion of transgenes (e.g., chimeric antigen receptors (CAR)) into T-cells. In some embodiments, the safe harbor loci of the present disclosure are useful for the insertion of a sequence encoding a transgene. In some embodiments, the safe harbor sites allow for high transgene expression (sufficient to allow for transgene functionality or treatment of a disease of interest) and stable expression of the transgene over several days, weeks or months. In some embodiments, knockout of the gene at the safe harbor locus confers benefit to the function of the cell, or the gene at the safe harbor locus has no known function within the cell. In some embodiments the safe harbor locus results in stable transgene expression in vitro with or without CD3/CD28 stimulation, negligible off-target cleavage as detected by iGuide-Seq or CRISPR-Seq, less off-target cleavage relative to other loci as detected by iGuide-Seq or CRISPR-Seq, negligible transgene-independent cytotoxicity, negligible transgene-independent cytokine expression, negligible transgene-independent chimeric antigen receptor expression, negligible deregulation or silencing of nearby genes, and positioned outside of a cancer-related gene.

As used, a “nearby gene” can refer to a gene that is within about 100 kB, about 125 kB, about 150 kB, about 175 kB, about 200 kB, about 225 kB, about 250 kB, about 275 kB, about 300 kB, about 325 kB, about 350 kB, about 375 kB, about 400 kB, about 425 kB, about 450 kB, about 475 kB, about 500 kB, about 525 kB, about 550 kB away from the safe harbor locus (integration site).

In some embodiments, the present disclosure contemplates inserts that comprise one or more transgenes. The transgene can encode a therapeutic protein, an antibody, a peptide, a suicide gene, an apoptosis gene or any other gene of interest. The safe harbor loci identified using the method described herein allow for transgene integration that results in, for example, enhanced therapeutic properties. These enhanced therapeutic properties, as used herein, refer to an enhanced therapeutic property of a cell when compared to a typical immune cell of the same normal cell type. For example, an NK cell having “enhanced therapeutic properties” has an enhanced, improved, and/or increased treatment outcome when compared to a typical, unmodified and/or naturally occurring NK cell. The therapeutic properties of immune cells can include, but are not limited to, cell transplantation, transport, homing, viability, self-renewal, persistence, immune response control and regulation, survival, and cytotoxicity. The therapeutic properties of immune cells are also manifested by: antigen-targeted receptor expression; HLA presentation or lack thereof; tolerance to the intratumoral microenvironment; induction of bystander immune cells and immune regulation; improved target specificity with reduction; resistance to treatments such as chemotherapy.

As used herein, the term “insert size” refers to the length of the nucleotide sequence being integrated (inserted) at the safe harbor site. In some embodiments, the insert size comprises at least about 100, 200, 300, 400 or 500 basepairs. In some embodiments, the insert size comprises about 500 nucleotides or basepairs. In some embodiments, the insert size comprises up to 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 kbp (kilo basepairs) or the sizes in between. In some embodiments, the insert size is greater than 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 kbp or the sizes in between. In some embodiments, the insert size is within the range of 3-15 kbp or is any number in that range. In some embodiments, the insert size is within the range of 1.5-8.3 kbp or is any number in that range. In some embodiments, the insert size is within the range of 1.5-15 kbp or is any number in that range. In some embodiments, the insert size is within the range of 0.5-20 kbp or is any number in that range. In some embodiments, the insert size is 0.5-10, 0.6-10, 0.7-10, 0.8-10, 0.9-10, 1-10, 2-10, 3-10, 4-10, 5-10, 6-10, 7-10, 8-10, 9-10 kbp. In some embodiments, the insert size is 0.5-11, 0.6-11, 0.7-11, 0.8-11, 0.9-11, 1-11, 2-11, 3-11, 4-11, 5-11, 6-11, 7-11, 8-11, 9-11, or 10-11 kbp. In some embodiments, the insert size is 0.5-12, 0.6-12, 0.7-12, 0.8-12, 0.9-12, 1-12, 2-12, 3-12, 4-12, 5-12, 6-12, 7-12, 8-12, 9-12, 10-12, or 11-12 kbp. In some embodiments, the insert size is 0.5-13, 0.6-13, 0.7-13, 0.8-13, 0.9-13, 1-13, 2-13, 3-13, 4-13, 5-13, 6-13, 7-13, 8-13, 9-13, 10-13, 11-13, or 12-13 kbp. In some embodiments, the insert size is 0.5-14, 0.6-14, 0.7-14, 0.8-14, 0.9-14, 1-14, 2-14, 3-14, 4-14, 5-14, 6-14, 7-14, 8-14, 9-14, 10-14, 11-14, 12-14 or 13-14 kbp. In some embodiments, the insert size is 0.5-15, 0.6-15, 0.7-15, 0.8-15, 0.9-15, 2-15, 3-15, 4-15, 5-15, 6-15, 7-15, 8-15, 9-15, 10-15, 11-15, 12-15, 13-15, or 14-15 kbp. In some embodiments, the insert size is 0.5-16, 0.6-16, 0.7-16, 0.8-16, 0.9-16, 1-16, 2-16, 3-16, 4-16, 5-16, 6-16, 7-16, 8-16, 9-16, 10-16, 11-16, 12-16, 13-16, 14-16 or 15-16 kbp. In some embodiments, the insert size is 0.5-17, 0.6-17, 0.7-17, 0.8-17, 0.9-17, 1-17, 2-17, 3-17, 4-17, 5-17, 6-17, 7-17, 8-17, 9-17, 10-17, 11-17, 12-17, 13-17, or 14-17, 15-17 or 16-17 kbp. In some embodiments, the insert size is 0.5-18, 0.6-18, 0.7-18, 0.8-18, 0.9-18, 1-18, 2-18, 3-18, 4-18, 5-18, 6-18, 7-18, 8-18, 9-18, 10-18, 11-18, 12-18, 13-18, 14-18, 15-18, 16-18 or 17-18 kbp. In some embodiments, the insert size is 0.5-19, 0.6-19, 0.7-19, 0.8-19, 0.9-19, 1-19, 2-19, 3-19, 4-19, 5-19, 6-19, 7-19, 8-19, 9-19, 10-19, 11-19, 12-19, 13-19, 14-0.7-20, 19, 15-19, 16-19, 17-19, or 18-19 kbp. In some embodiments, the insert size is 0.5-20, 0.6-20, 0.7-20, 0.8-20, 0.9-20, 1-20, 2-20, 3-20, 4-20, 5-20, 6-20, 7-20, 8-20, 9-20, 10-20, 11-20, 12-20, 13-20, 14-20, 15-20, 16-20, 17-20, 18-20, or 19-20 kbp.

The inserts of the present disclosure refer to nucleic acid molecules or polynucleotide inserted at a safe harbor site. In some embodiments, the nucleotide sequence is a DNA molecule, e.g., genomic DNA, or comprises deoxy-ribonucleotides. In some embodiments, the insert comprises a smaller fragment of DNA, such as a plastid DNA, mitochondrial DNA, or DNA isolated in the form of a plasmid, a fosmid, a cosmid, a bacterial artificial chromosome (BAC), a yeast artificial chromosome (YAC), and/or any other sub-genome segment of DNA. In some embodiments, the insert is an RNA molecule or comprises ribonucleotides. The nucleotides in the insert are contemplated as naturally occurring nucleotides, non-naturally occurring, and modified nucleotides. Nucleotides may be modified chemically or biochemically, or may contain non-natural or derivatized nucleotide bases, as will be readily appreciated by those of skill in the art. Such modifications include, for example, labels, methylation, substitution of one or more of the naturally occurring nucleotides with an analog, internucleotide modifications. The polynucleotides can be in any topological conformation, including single-stranded, double-stranded, partially duplexed, triplexed, hairpinned, circular conformations, and other three-dimension conformations contemplated in the art.

The inserts can have coding and/or non-coding regions. The insert can comprises a non-coding sequence (e.g., control elements, e.g., a promoter sequence). In some embodiments, the insert encodes transcription factors. In some embodiments, the insert encodes an antigen binding receptors such as single receptors, T-cell receptors (TCRs), syn-notch, CARs, mAbs, etc. In some embodiments, the inserts are RNAi molecules, including, but not limited to, miRNAs, siRNA, shRNAs, etc. In some embodiments, the insert is a human sequence. In some embodiments, the insert is chimeric. In some embodiments, the insert is a multi-gene/multi-module therapeutic cassette. A multi-gene/multi-module therapeutic cassette referst to an insert or cassette having one or more than one receptor (e.g., synthetic receptors), other exogenous protein coding sequences, non-coding RNAs, transcriptional regulatory elements, and/or insulator sequences, etc.

Various cell types are contemplated as having the safe harbor sites in the present disclosure. A cell comprising a safe harbor site and/or a cell comprising an insert at a safe harbor site as described in the present disclosure can be referred to as an engineered cell. The cells can include, but are not limited to, eukaryotic cells, prokaryotic cells, animal cells, plant cells, fungal cells and the like. Optionally, the cell is a mammalian cell, for example, a human cell. In some embodiments, that engineered cell is a stem cell, a human cell, a primary cell, an hematopoietic cell, an adaptive immune cell, an innate immune cell, a T cell or a T cell progenitor. Non-limiting examples of immune cells that are contemplated in the present disclosure include T cell, B cell, natural killer (NK) cell, NKT/iNKT cell, macrophage, myeloid cell, and dendritic cells. Non-limiting examples of stem cells that are contemplated in the present disclosure include pluripotent stem cells (PSCs), embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), embryo-derived embryonic stem cells obtained by nuclear transfer (ntES; nuclear transfer ES), male germline stem cells (GS cells), embryonic germ cells (EG cells), hematopoietic stem/progenitor stem cells (HSPCs), somatic stem cells (adult stem cells), hemangioblasts, neural stem cells, mesenchymal stem cells and stem cells of other cells (including osteocyte, chondrocyte, myocyte, cardiac myocyte, neuron, tendon cell, adipocyte, pancreocyte, hepatocyte, nephrocyte and follicle cells and so on). In some embodiments, the engineered cells is a T cell, NK cells, iPSC, and HSPC. In some embodiments, the engineered cells used in the present disclosure are human cell lines grown in vitro (e.g. deliberately immortalized cell lines, cancer cell lines, etc.).

The methods for integrating the inserts at the safe harbor sites can be viral or non-viral delivery techniques.

In some embodiments, the nucleic acid sequence is inserted into the genome of the engineered cell by introducing a vector, for example, a viral vector, comprising the nucleic acid. Examples of viral vectors include, but are not limited to, adeno-associated viral (AAV) vectors, retroviral vectors or lentiviral vectors. In some embodiments, the lentiviral vector is an integrase-deficient lentiviral vector.

In some embodiments, the nucleic acid sequence is inserted into the genome of the T cell via non-viral delivery. In non-viral delivery methods, the nucleic acid can be naked DNA, or in a non-viral plasmid or vector. Non-viral delivery techniques can be site-specific integration techniques, as described herein or known to those of ordinary skill in the art. Examples of site-specific techniques for integration into the safe harbor loci include, without limitation, homology-dependent engineering using nucleases and homology independent targeted insertion using Cas9.

In some embodiments, the insert is integrated at a safe harbor site by introducing into the engineered cell, (a) a targeted nuclease that cleaves a target region in the safe harbor site to create the insertion site; and (b) the nucleic acid sequence (insert), wherein the insert is incorporated at the insertion site by, e.g., HDR. Examples of non-viral delivery techniques that can be used in the methods of the present disclosure are provided in U.S. application Ser. Nos. 16/568,116 and 16/622,843, the relevant disclosures of which are herein incorporated by reference in their entirety.

2. CAR T Cell Therapy

Chimeric antigen receptor (CAR) T cells are T cells that have been genetically engineered to produce an artificial T-cell receptor for use in immunotherapy. Chimeric antigen receptors are receptor proteins that have been engineered to confer T cells with the ability to target a specific protein. The genetic modification of lymphocytes (e.g. T cells) by incorporation of, for example, CARs, and administration of the engineered cells to a subject is an example of “adoptive cell therapy”. As used herein, the term “adoptive cell therapy” refers to cell-based immunotherapy for transfusion of autologous or allogeneic lymphocytes, referred to as T cells or B cells. In this CAR therapy approach, cells are expanded and cultured ex vivo and genetically modified, prior to transfusion.

The expression of CARs allows the engineered T-cells to target and bind specific proteins, for example, tumor antigens. In CAR therapy, T-cells are harvested from a subject—they can be autologous T-cells from the subject own blood or from a donor that will not be receiving the CAR therapy. Once isolated, the T-cells are genetically modified with a CAR, expanded ex vivo, and administered to the subject (i.e. patient) by, e.g. infusion.

The CARs may be introduced into the T-cells using, for example, a viral technique (e.g., retroviral integration) or site-specific technique. With site specific integration of the transgenes (e.g. CARs), the transgenes may be targeted to a safe harbor locus. Examples of site-specific techniques for integration into the safe harbor loci include, without limitation, homology-dependent engineering using nucleases and homology independent targeted insertion using Cas9.

The engineered CAR T cells have applications to immune-oncology. The CAR, for example, can be selected to target a specific tumor antigen. Examples of cancers that can be effectively targeted using CAR T cells are blood cancers. In some embodiments, CAR T cell therapy can be used to treat solid tumors.

3. Gene Editing

The terms “gene editing” or “genome editing”, as used herein, refer to a type of genetic manipulation in which DNA is inserted, replaced, or removed from the genome using artificially manipulated nucleases or “molecular scissors”. It is a useful tool for elucidating the function and effect of sequence-specific genes or proteins or altering cell behavior (e.g. for therapeutic purposes).

Currently available genome editing tools include zinc finger nucleases (ZFN) and transcription activator-like effector nucleases (TALENs) to incorporate genes at safe harbor loci (e.g. the adeno-associated virus integration site 1 (AAVS1) safe harbor locus). The DICE (dual integrase cassette exchange) system utilizing phiC31 integrase and Bxb1 integrase is a tool for target integration. Additionally, clustered regularly interspaced short palindromic repeat/Cas9 (CRISPR/Cas9) techniques can be used for targeted gene insertion.

Site specific gene editing approaches can include homology dependent mechanisms or homology independent mechanisms.

All methods known in the art for targeted insertion of gene sequences are contemplated in the methods described herein to insert constructs at safe harbor loci.

4. Crispr-Cas Gene Editing

One effective example of gene editing is the Crisp-Cas approach (e.g. Crispr-Cas9). This approach incorporates the use of a guide polynucleotide (e.g. guide ribonucleic acid or gRNA) and a cas endonuclease (e.g. Cas9 endonuclease).

As used herein, a polypeptide referred to as a “Cas endonuclease” or having “Cas endonuclease activity” refers to a CRISPR-related (Cas) polypeptide encoded by a Cas gene, wherein a Cas polypeptide is a target DNA sequence that can be cleaved when operably linked to one or more guide polynucleotides (see, e.g., U.S. Pat. No. 8,697,359). Also included in this definition are variants of Cas endonuclease that retain guide polynucleotide-dependent endonuclease activity. The Cas endonuclease used in the donor DNA insertion method detailed herein is an endonuclease that introduces double-strand breaks into DNA at the target site (e.g., within the target locus or at the safe harbor site).

As used herein, the term “guide polynucleotide” relates to a polynucleotide sequence capable of complexing with a Cas endonuclease and allowing the Cas endonuclease to recognize and cleave a DNA target site. The guide polynucleotide can be a single molecule or a double molecule. The guide polynucleotide sequence can be an RNA sequence, a DNA sequence, or a combination thereof (RNA-DNA combination sequence). A guide polynucleotide comprising only ribonucleic acid is also referred to as “guide RNA”. In some embodiments, a polynucleotide donor construct is inserted at a safe harbor locus using a guide RNA (gRNA) in combination with a cas endonuclease (e.g. Cas9 endonuclease).

The guide polynucleotide includes a first nucleotide sequence domain (also referred to as a variable targeting domain or VT domain) that is complementary to a nucleotide sequence in the target DNA, and a second nucleotide that interacts with a Cas endonuclease polypeptide. It can be a double molecule (also referred to as a double-stranded guide polynucleotide) comprising a sequence domain (referred to as a Cas endonuclease recognition domain or CER domain). The CER domain of this double molecule guide polynucleotide comprises two separate molecules that hybridize along the complementary region. The two separate molecules can be RNA sequences, DNA sequences and/or RNA-DNA combination sequences.

Genome editing using CRISPR-Cas approaches relies on the repair of site-specific DNA double-strand breaks (DSBs) induced by the RNA-guided Cas endonuclease (e.g. Cas 9 endonuclease). Homology-directed repair (HDR) of these DSBs enables precise editing of the genome by introducing defined genomic changes, including base substitutions, sequence insertions, and deletions. Conventional HDR-based CRISPR/Cas9 genome-editing involves transfecting cells with Cas9, gRNA and donor DNA containing homologous arms matching the genomic locus of interest.

HITI (homology independent targeted insertion) uses a non-homologous end joining (NHEJ)-based homology-independent strategy and the method can be more efficient than HDR. Guide RNAs (gRNAs) target the insertion site. For HITI, donor plasmids lack homology arms and DSB repair does not occur through the HDR pathway. The donor polynucleotide construct can be engineered to include Cas9 cleavage site(s) flanking the gene or sequence to be inserted. This results in Cas9 cleavage at both the donor plasmid and the genomic target sequence. Both target and donor have blunt ends and the linearized donor DNA plasmid is used by the NHEJ pathway resulting integration into the genomic DSB site. (See, for example, Suzuki, K., et al. (2016). In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration. Nature, 540(7631), 144-149, the relevant disclosures of which are herein incorporated in their entirety).

Methods for conducing gene editing using CRISPR-Cas approaches are known to those of ordinary skill in the art. (See, for example, U.S. application Ser. No. 16/312,676, U.S. Ser. No. 15/303,722, and U.S. Ser. No. 15/628,533, the disclosures of which are herein incorporated by reference in their entirety). Additionally, uses of endonucleases for inserting transgenes into safe harbor loci are described, for example, in U.S. application Ser. No. 13/036,343, the disclosures of which are herein incorporated by reference in their entirety.

The guide RNAs and/or mRNA (or DNA) encoding an endonuclease can be chemically linked to one or more moieties or conjugates that enhance the activity, cellular distribution, or cellular uptake of the oligonucleotide. Non-limiting examples of such moieties include lipid moieties such as a cholesterol moiety, cholic acid, a thioether, a thiocholesterol, an aliphatic chain (e.g., dodecandiol or undecyl residues), a phospholipid, e.g., di-hexadecyl-rac-glycerol or triethylammonium 1,2-di-O-hexadecyl-rac-glycero-3-H-phosphonate, a polyamine or a polyethylene glycol chain, adamantane acetic acid, a palmityl moiety and an octadecylamine or hexylamino-carbonyl-t oxycholesterol moiety. See for example U.S. application Ser. No. 15/715,068, the disclosures of which are herein incorporated by reference in their entirety.

5. Therapeutic Applications

For therapeutic applications, the engineered cells, populations thereof, or compositions thereof are administered to a subject, generally a mammal, generally a human, in an effective amount.

The engineered cells may be administered to a subject by infusion (e.g., continuous infusion over a period of time) or other modes of administration known to those of ordinary skill in the art.

The engineered cells provided herein can be administered as part of a pharmaceutical compositions. In some embodiments, the present disclosure provides compositions comprising a guide RNA of the present disclosure. The pharmaceutical composition may comprise one or more pharmaceutical excipients. Any suitable pharmaceutical excipient may be used, and one of ordinary skill in the art is capable of selecting suitable pharmaceutical excipients. Accordingly, the pharmaceutical excipients provided below are intended to be illustrative, and not limiting. Additional pharmaceutical excipients include, for example, those described in the Handbook of Pharmaceutical Excipients, Rowe et al. (Eds.) 6th Ed. (2009), incorporated by reference in its entirety.

The engineered cells provided herein not only find use in gene therapy but also in non-pharmaceutical uses such as, e.g., production of animal models and production of recombinant cell lines expressing a protein of interest.

The engineered cells of the present disclosure can be any cell, generally a mammalian cell, generally a human cell that has been modified by integrating a transgene at a safe harbor locus described herein. In some embodiments, the engineered cells are immune cells. In some embodiments, the engineered cells are lymphocytes. In some embodiments, the engineered cells are T cells or T cell precursors.

The engineered cells, compositions and methods of the present disclosure are useful for therapeutic applications such as CAR T cell therapy and TCR T cell therapy. In some embodiments, the insertion of a sequence encoding a transgene within a safe harbor locus maintains the TCR expression relative to instances when there is no insertion and enables transgene expression while maintaining TCR function.

Various diseases treated using the engineered cells, populations thereof, or compositions thereof are provided herein. Non-limiting examples of such diseases include alopecia areata, autoimmune hemolytic anemia, autoimmune hepatitis, cancer, dermatomyositis, diabetes (type 1), certain juvenile idiopathic arthritis, glomerulonephritis, Graves' disease, Guillain Valley Syndrome, idiopathic thrombocytopenic purpura, myasthenia gravis, certain myocarditis, multiple sclerosis, pemphigus/pemphigoid, pernicious anemia, polyarteritis nodosa, polymyositis, primary bile With cirrhosis, psoriasis, rheumatoid arthritis, scleroderma/systemic sclerosis, Sjogren's syndrome, systemic lupus erythematosus, certain thyroiditis, certain uveitis, vitiligo, multiple vasculitis (Wegener)); autoimmune disorders including, but not limited to, granulomatosis; hematopoietic tumors including but not limited to acute and chronic leukemia, lymphoma, multiple myeloma and myelodysplastic syndrome; tumors of the prostate, breast, lung, colon, uterus, skin, liver, bone, pancreas, ovary, testis, bladder, kidney, head, neck, stomach, cervix, rectum, larynx, or esophagus solid tumors; HIV (human immunodeficiency virus) related disorders, RSV (respiratory syncytial virus) related disorders; EBV (Epstein-Barr virus) related disorders; CMV (cytomegalovirus) related disorders; and infectious diseases including, but not limited to, adenovirus-related disorders and BK polyomavirus-related disorders.

Cancers that can be treated with the engineered cells (e.g., CAR T-cells) of the present disclosure, populations thereof, or compositions thereof include blood cancers. In some embodiments, the cancer treated using the engineered cells (e.g., CAR T-cells) described herein, populations thereof, or compositions thereof is a hematologic malignancy or leukemia. In some embodiments, the engineered cells (e.g., CAR T-cells) described herein, populations thereof, or compositions thereof are used for the treatment of acute lymphoblastic leukemia (ALL) or diffuse large B-cell lymphoma (DLBCL). In some embodiments, the cancer is acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), myelodysplasia, myelodysplastic syndromes, acute T-lymphoblastic leukemia, or acute promyelocytic leukemia, chronic myelomonocytic leukemia, or myeloid blast crisis of chronic myeloid leukemia. Examples of cancers treatable using the engineered cells (e.g., CAR T-cells) described herein include, without limitation, breast cancer, ovarian cancer, esophageal cancer, bladder or gastric cancer, salivary duct carcinoma, salivary duct carcinomas, adenocarcinoma of the lung or aggressive forms of uterine cancer, such as uterine serous endometrial carcinoma. In some other embodiments, the cancer is brain cancer, breast cancer, cervical cancer, colon cancer, colorectal cancer, endometrial cancer, esophageal cancer, leukemia, lung cancer, liver cancer, melanoma, ovarian cancer, pancreatic cancer, rectal cancer, renal cancer, stomach cancer, testicular cancer, or uterine cancer. In yet other embodiments, the cancer is a squamous cell carcinoma, adenocarcinoma, small cell carcinoma, melanoma, neuroblastoma, sarcoma (e.g., an angiosarcoma or chondrosarcoma), larynx cancer, parotid cancer, biliary tract cancer, thyroid cancer, acral lentiginous melanoma, actinic keratoses, acute lymphocytic leukemia, acute myeloid leukemia, adenoid cystic carcinoma, adenomas, adenosarcoma, adenosquamous carcinoma, anal canal cancer, anal cancer, anorectum cancer, astrocytic tumor, bartholin gland carcinoma, basal cell carcinoma, biliary cancer, bone cancer, bone marrow cancer, bronchial cancer, bronchial gland carcinoma, carcinoid, cholangiocarcinoma, chondrosarcoma, choroid plexus papilloma/carcinoma, chronic lymphocytic leukemia, chronic myeloid leukemia, clear cell carcinoma, connective tissue cancer, cystadenoma, digestive system cancer, duodenum cancer, endocrine system cancer, endodermal sinus tumor, endometrial hyperplasia, endometrial stromal sarcoma, endometrioid adenocarcinoma, endothelial cell cancer, ependymal cancer, epithelial cell cancer, Ewing's sarcoma, eye and orbit cancer, female genital cancer, focal nodular hyperplasia, gallbladder cancer, gastric antrum cancer, gastric fundus cancer, gastrinoma, glioblastoma, glucagonoma, heart cancer, hemangioblastomas, hemangioendothelioma, hemangiomas, hepatic adenoma, hepatic adenomatosis, hepatobiliary cancer, hepatocellular carcinoma, Hodgkin's disease, ileum cancer, insulinoma, intraepithelial neoplasia, interepithelial squamous cell neoplasia, intrahepatic bile duct cancer, invasive squamous cell carcinoma, jejunum cancer, joint cancer, Kaposi's sarcoma, pelvic cancer, large cell carcinoma, large intestine cancer, leiomyosarcoma, lentigo maligna melanomas, lymphoma, male genital cancer, malignant melanoma, malignant mesothelial tumors, medulloblastoma, medulloepithelioma, meningeal cancer, mesothelial cancer, metastatic carcinoma, mouth cancer, mucoepidermoid carcinoma, multiple myeloma, muscle cancer, nasal tract cancer, nervous system cancer, neuroepithelial adenocarcinoma nodular melanoma, non-epithelial skin cancer, non-Hodgkin's lymphoma, oat cell carcinoma, oligodendroglial cancer, oral cavity cancer, osteosarcoma, papillary serous adenocarcinoma, penile cancer, pharynx cancer, pituitary tumors, plasmacytoma, pseudosarcoma, pulmonary blastoma, rectal cancer, renal cell carcinoma, respiratory system cancer, retinoblastoma, rhabdomyosarcoma, sarcoma, serous carcinoma, sinus cancer, skin cancer, small cell carcinoma, small intestine cancer, smooth muscle cancer, soft tissue cancer, somatostatin-secreting tumor, spine cancer, squamous cell carcinoma, striated muscle cancer, submesothelial cancer, superficial spreading melanoma, T cell leukemia, tongue cancer, undifferentiated carcinoma, ureter cancer, urethra cancer, urinary bladder cancer, urinary system cancer, uterine cervix cancer, uterine corpus cancer, uveal melanoma, vaginal cancer, verrucous carcinoma, VIPoma, vulva cancer, well-differentiated carcinoma, or Wilms tumor.

In some embodiments, the present disclosure provides methods of treating a subject in need of treatment by administering to the subject a composition comprising any of the engineered cells described herein. As used, the terms “treat,” “treatment,” and the like refer generally to obtaining a desired pharmacological and/or physiological effect. That effect is preventive in terms of complete or partial prevention of the disease and/or therapeutic in terms of partial or complete cure of the disease and/or adverse effects resulting from the disease. The term “treatment”, as used herein, encompasses any treatment of a disease in a subject (e.g., mammal, e.g., human). Treatment may also refer to the administration of the engineered cells provided herein to a subject that is susceptible to the disease but has not yet been diagnosed as suffering from it, including preventing the disease from occurring; inhibiting disease progression; or reducing the disease (i.e., causing a regression of the disease). Further, treatment may stabilize or reduce undesirable clinical symptoms in subjects (e.g., patients). The cells provided herein populations thereof, or compositions thereof may be administered before, during or after the occurrence of the disease or injury.

In certain embodiments, the subject has a disease, condition, and/or injury that can be treated and/or ameliorated by cell therapy. In some embodiments, the subject in need of cell therapy is a subject having an injury, disease, or condition, thereby causing cell therapy (e.g., therapy in which cellular material is administered to the subject). However, it is contemplated that it is possible to treat, ameliorate and/or reduce the severity of at least one symptom associated with the injury, disease or condition. In certain embodiments, a subject in need of cell therapy includes, but is not limited to, a bone marrow transplant or stem cell transplant candidate, a subject who has received chemotherapy or radiation therapy, a hyperproliferative disease or cancer (e.g., a hematopoietic system), a subject having or at risk of developing a hyperproliferative disease or cancer), a subject having or at risk of developing a tumor (e.g., solid tumor), viral infection or virus. It is also intended to encompass subjects suffering from or at risk of suffering from a disease associated with an infection.

In some embodiments, the present disclosure provides a composition of the present disclosure along with instructions for use. The instructions for use can be present in the kits as a package insert, in the labeling of the container of the kit or components thereof, or can be in digital form (e.g. on a CD-ROM, via a link on the internet). A kit can include one or more of a genome-targeting nucleic acid, a polynucleotide encoding a genome-targeting nucleic acid, a site-directed polypeptide, and/or a polynucleotide encoding a site-directed polypeptide. Additional components within the kits are also contemplated, for example, buffer (such as reconstituting buffer, stabilizing buffer, diluting buffer), and/or one or more control vectors.

6. Combination Therapies

In some embodiments, an engineered cells of the present disclosure or composition thereof is administered with at least one additional therapeutic agent. Any suitable additional therapeutic agent may be administered with an engineered cell provided herein, populations thereof, or compositions thereof. In some aspects, the additional therapeutic agent is selected from radiation, an ophthalmologic agent, a cytotoxic agent, a chemotherapeutic agent, a cytostatic agent, an anti-hormonal agent, an immunostimulatory agent, an anti-angiogenic agent, and combinations thereof.

In some embodiments, an engineered cell of the present disclosure or composition thereof is administered with a steroid. The administration of a steroid can prevent or mitigate the risk of a subject receiving the engineered cell(s) or composition thereof having an autoimmune reaction.

The additional therapeutic agent may be administered by any suitable means. In some embodiments, the engineered cells described herein, populations thereof, or compositions thereof and the additional therapeutic agent is administered in the same pharmaceutical composition, e.g. by infusion. In some embodiments, the engineered cells described herein and additional therapeutic agent are included in different pharmaceutical compositions.

The pharmaceutical composition may comprise one or more pharmaceutical excipients. Any suitable pharmaceutical excipient may be used, and one of ordinary skill in the art is capable of selecting suitable pharmaceutical excipients. Accordingly, the pharmaceutical excipients provided below are intended to be illustrative, and not limiting. Additional pharmaceutical excipients include, for example, those described in the Handbook of Pharmaceutical Excipients, Rowe et al. (Eds.) 6th Ed. (2009), incorporated by reference in its entirety.

Various modes of administering the additional therapeutic agents are contemplated herein. In some embodiments, the additional therapeutic agent is administered by any suitable mode of administration. Generally, modes of administration include, without limitation, intravitreal, subretinal, suprachoroidal, intraarterial, intradermal, intramuscular, intraperitoneal, intravenous, nasal, parenteral, topical, pulmonary, and subcutaneous routes.

In embodiments where the engineered cells provided herein and the additional therapeutic agent are included in different pharmaceutical compositions, administration of the engineered cells provided herein can occur prior to, simultaneously, and/or following, administration of the additional therapeutic agent.

EXAMPLES

The following are examples of methods and compositions of the invention. It is understood that various other embodiments may be practiced, given the general description provided herein.

Below are examples of specific embodiments for carrying out the present invention. The examples are offered for illustrative purposes only, and are not intended to limit the scope of the present invention in any way. Efforts have been made to ensure accuracy with respect to numbers used (e.g., amounts, temperatures, etc.), but some experimental error and deviation should, of course, be allowed for.

The practice of the present invention will employ, unless otherwise indicated, conventional methods of protein chemistry, biochemistry, recombinant DNA techniques and pharmacology, within the skill of the art. Such techniques are explained fully in the literature. See, e.g., T. E. Creighton, Proteins: Structures and Molecular Properties (W.H. Freeman and Company, 1993); A. L. Lehninger, Biochemistry (Worth Publishers, Inc., current addition); Sambrook, et al., Molecular Cloning: A Laboratory Manual (2nd Edition, 1989); Methods In Enzymology (S. Colowick and N. Kaplan eds., Academic Press, Inc.); Remington's Pharmaceutical Sciences, 18th Edition (Easton, Pennsylvania: Mack Publishing Company, 1990).

Example 1: Identification of Knock-In Loci in Coding Regions

The objective of the experiments in this set of examples was to identify T-cell knock-in (KI) loci in coding regions outside of the T Cell Receptor Alpha Constant (TRAC) locus. To select candidate loci, the criteria and requirements shown in Table 1 were used.

TABLE 1

Criteria used for identification of candidate knock-in loci

within coding regions

Detailed
Datasets Considered for

Criteria
Requirements
identification of loci

KI
High expression at
Knock in efficiency

efficiency
d2 (day 2)
data on ~90 genes

Similar expression
derived from

dynamics as TRAC
Roth, T. L., et al. 2019.

(stable expression
(Rapid discovery of synthetic

upon activation)
DNA sequences to rewrite endogenous

Accessible
T cell circuits. bioRxiv, 604561.)

chromatin
Bulk RNA-seq data at do, d2, d3 and d4:

gRNA editing
(i) publicly available data;

efficiency
(ii) data derived from Roth,

T. L., et al. 2019.

(Rapid discovery of synthetic

DNA sequences to rewrite

endogenous T cell circuits.

bioRxiv, 604561.); and

(iii) internally generated data

Bulk ATAC-seq data

at do, d2, d3 and d4:

(i) data derived from Roth,

T. L., et al. 2019.

(Rapid discovery of

synthetic DNA sequences

to rewrite endogenous T cell

circuits. bioRxiv, 604561.); and

(ii) internally generated data

Safety
Does not affect
T cell screening data

proliferation,
Achilles' project on cancer cell lines data

cytolytic activity or
Annotated oncogenes and tumor

signaling of T cells
suppressors from TCGA

Annotated functions in immune cells

Be careful with

tumor suppressors

and oncogenes

Generally, the requirements for candidate KI loci within the coding regions was that the coding gene is not essential for T cell function or the knock-out of that gene would be beneficial to chimeric antigen receptor therapy (CAR T) functions.

As shown in Table 1, some of the data utilized, for comparison purposes, to identify candidate KI loci was sourced, in part, from Roth, T. L., et al. 2019 (Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits. bioRxiv, 604561), the relevant disclosures of which are herein incorporated by reference in their entirety. A summary of data in the Roth, T. L. et al. paper is shown in FIG. 3.

FIG. 4A and FIG. 4B show the processed RNA-seq data, showing that samples cluster based on activation status and by cell type. Donor 4 (AKI4) was identified as an outlier, as it clustered differently than the others, and was removed from remaining analysis. The transcript expression data from RNA-seq experiments on the 90 genes cited in the Roth, T. L. et al. paper was correlated to transcript expression data in Roth, T. L. et al. paper. (See FIG. 5A and FIG. 5B).

FIG. 6 shows the process ATAC-seq data, which focused on the 10 kb area around the transcription start site (TSS). Again, donor 4 (AK14) was identified as an outlier, based on expression profile in both CD4 and CD8 cells, and was removed from remaining analysis. The results of the remaining ATAC-seq analysis are shown in FIGS. 7A-8. The data in FIG. 7A for TSS enrichment scores also indicated that all libraries were high quality. The data on open chromatin regions around the TRAC locus revealed the highest signal near exon 3 rather than exon 1 (FIG. 8).

Determination of Knock-In Efficiency:

The K1 efficiency results (obtained using the model described infra) based on the 5 donors, 2 gRNA, and 2 replicates/gRNAs from the Roth, T. L. et al. paper are shown in FIG. 9 and FIG. 10.

A linear model was built to estimate KI efficiency of approximately 90 genes using RNA-seq and ATAC-seq data. The linear model captured 33% of the variation in the data (i.e. R²=0.33). FIG. 11 shows KI efficiency versus day 2 (d2) RNA-seq data, day 4 (d4) RNA seq data, and d2 ATAC data. The linear model was applied to remaining candidate genes to estimate their KI efficiency.

The candidate coding loci were selected by first ranking all genes in the pooled data sets by predicted KI efficiency, using RNA-seq expression data from d2 (day 2). Candidate coding loci were required to be stably expressed during T cell activation (e.g., <=2-fold expression change relative to day 0 (d0). The candidate loci also had to be accessible based on ATAC-seq data. Using that selection process/requirements, 16 well-characterized coding genes (with known functions) were selected as candidate genes. The knockout of these 16 would confer a benefit to the function of CART cells (e.g. B2M, CD5, SMAD2, PTPRC, CD3E). An additional 12 coding genes with high predicted KI efficiency and no apparent essential function (inert coding genes) were selected as candidate genes. (See Table 2).

TABLE 2

KI Candidate Loci selected

Genes with Known Functions
Inert Coding Genes

B2M (~70%)
CD2
SUB1

CD3E (~50%)
SMAD2
EDF1

PTPRC (~50%)
SLC38A1
CAPNS1

CD3G (~30%)
TIGIT
SRP14

custom-character

SOCS1 PTPN2
RTRAF APRT

Tested in Roth, T.L. et al
CBLB
PTPRCAP

paper (reported editing
PTEN
SRSF9

efficiency from Roth,
PTPN6
FTL

T.L. et al paper)
CD5
TRIM28

TET2
SERF2

TRAC
RPS23

Example 2: Identification of Knock-In Loci in Gene Deserts

The criteria for selection of candidate loci in non-coding regions or gene deserts is summarized in Table 3.

TABLE 3

Criteria used for identification of candidate knock-in loci within

non-coding regions

Datasets Considered for

Criteria
Detailed Requirements
identification of loci

KI
Accessible chromatin
Bulk ATAC-seq data

efficiency

at d0, d2, d3 and d4:

(i) data derived from

Roth, T. L., et al. 2019.

(Rapid discovery of synthetic

DNA sequences to rewrite

endogenous T cell circuits.

bioRxiv, 604561.); and

(ii) internally generated data

Safety
>10 kb from cancer-related
Ensembl genes

genes or TADS
Annotated oncogenes and tumor

>10 kb from any
suppressors from TCGA

miRNA/functional small
Annotated enhancers

RNAs
from Encode and papers

>10 kb from any 5' gene

end

>10 kb from any regulatory

regions (ultra-conserved

elements, enhancers)

To select candidate regions within the non-coding regions, the inventors here started by looking in highly accessible regions of the genome (10 kb windows). The most accessible region overlapped with (i) annotated protein coding genes (>50% accessible regions), (ii) pseudogenes and noncoding RNAs (˜20% accessible regions), and (iii) enhancer/regulatory regions (˜20% accessible regions). The candidate genes were required to be <10 kb from the coding regions. A few regions that overlapped with long intergenic noncoding RNAs (lincRNAs) but did not have apparent function in T cells were also considered.

Examples of other criteria that have been used in the art for selection of SHS are described, for example in Pellenz, S., et al. (2019). New human chromosomal sites with “safe harbor” potential for targeted transgene insertion. Human gene therapy, 30(7), 814-828, the relevant disclosures of which are herein incorporated by reference in their entirety.

FIG. 12 is a plot showing the normalized ATAQ SEQ data for a top candidate non-coding region.

Using the above-described selection process/requirement, 11 candidate regions in gene deserts were selected. In total, there were 39 KI candidate loci, including those in coding and non-coding regions that would be evaluated as safe harbor loci (predicted loci).

Example 3: Experimental Evaluation of Predicted Loci

Materials

- 120 sgRNAs were ordered from Synthego, 3 sgRNAs per region, and editing efficiency was assessed by next generation sequencings (NGS).
  - 87 targeted coding genes
  - 33 targeted gene deserts
- 189 constructs were synthesized by Genscript
  - Homology arm: 450 bp each
  - eGFP was used as the reporter
  - Vector backbone: pUC57-Kan backbone
  - 78 with endogenous promoters
  - 111 with EF1a-HTLV promoter
- Constructs were sequence verified by Genscript and majority were internally verified by sequencing. The sgRNA sequences are provided in Table 4 and the construct sequences are provided in Table 5.

Methods

To evaluate the effectiveness of the predicted loci, the following were used:

- (87 endogenous constructs+120 exogenous construct)*2=414 wells+Controls=460
- 3 donors, 2 replicates at 3 time points: wk 1 (d6=day 6), wk 3 (d21=day 21) and wk 4 (d28=day 28)
- Controls
- DNA-only (no ribonucleoprotein (RNP)): episomal expression (n=8)
- DNA+non-targeting guides+RNP: to check if DNA delivery is more efficient with RNP (n=8)

pMax GFP was measured to check if transfection is ok (n=3).

WT cells with no electroporation

WT cells with electroporation

Controls were spread out across plates.

Cells were electroporated without RNP/HDR to check if cell counting makes sense.

2 more donors were added and changed to 3 replicates at 1 time point: wk 1 (d6)

FACS panel: GFP, TCR, Zombie

Washed every 3 wells.

The secondary data collected included: RNA-seq data: at d0, d2, and d4 (to determine stable expression) and ATAC-seq data: at d2 (to identify activated cells). The methods used for conducting the RNA-seq and ATAC-seq experiments are in Roth, T. L., et al. 2019. (Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits. bioRxiv, 604561), which is herein incorporated by reference in its entirety.

Automated gating was performed on FACS data, using .fcs files. For constructs with endogenous promoters, all 5 donors and all 3 time points were used. For constructs with EF1a promoter, used 3 donors (donors 1-3) and 2 time points (wk 3 and wk 4).

To summarize data, wells with a % K1 efficiency (% GFP_high cells)<=10% (likely a gating error, experimental error or minimal integration) were removed. Loci were then ranked by median expression among donors and median % K1 efficiency among donors.

Loci significance was calculated using robust rank aggregation, which was the methodology used for consistent ranking of loci among donors and time points. Methods for conducting robust rank aggregation are known in the art. (See, for example, Kolde, R., et al. (2012). Robust rank aggregation for gene list integration and meta-analysis. Bioinformatics (Oxford, England), 28(4), 573-580, the disclosure of which is herein incorporated by reference in its entirety).

Results

The results from the analysis of controls and experimental groups is shown in FIGS. 13A-25.

The results of the pmax_GFP control experiments revealed that donor 5 had significantly higher cell count than other donors. Generally, the GFP_high readings decreased over time, as expected. (FIGS. 13A and 13B).

Experiments to analyze non-targeting controls for changes in episomal GFP expression, revealed that episomal GFP expression decreased to less than 0.05 over time. (FIGS. 14A and 14B) Some of the outliers were attributed to gating errors, which were most severe in donor 3. WT control experiments also exhibited <0.05 GFP_high readings, as expected (FIG. 15).

As shown in FIG. 16 and FIG. 17, there was a more consistent trend among donors when using sgRNAS to target the B2M safe harbor locus.

A comparison of GFP expression trends between sgRNA79 and sgRNA83 for TRAC insertion and expression with an endogenous reporter revealed that donor 2 trends were different between sgRNA79 and sgRNA83, while donor 4 trends were the same (FIG. 18 and FIG. 22). Some potential reasons for the observed variation between replicates and donors include:

- (1) manual handling of a large number of plates (e.g., FIG. 26):
  - Edge effects
  - Electroporation errors
- (2) Inherent differences among donors (e.g., FIG. 27):
  - There were consistent differences with certain wells throughput the assay (spanning multiple weeks)
  - There were variable cell numbers between donors
- (3) Gating errors (e.g. FIG. 28):
  - 1 peak vs >2 peaks in GFP signals

Example 4: Ranking Loci by Expression and KI Efficiency

The loci were ranked based on mean florescence intensity (MFI) of reporter gene, GFP, and KI efficiency.

FIG. 29 shows GFP MFI and KI efficiency for all significant loci having endogenous promoters. The B2M locus reported the highest GFP MFI. The TRAC locus was among the top 10 MFI. The highest GFP MFI readings were reported in week 1 and reduced slightly in weeks 3 and 4. The results also showed most top loci have more than 1 sgRNA. With regard to KI efficiency, the SOCS1 locus reported the highest KI efficiency. Overall, KI efficiency showed greater variation among donors than GFP MFI.

FIG. 30 shows GFP MFI and KI efficiency for all significant loci having exogenous promoters (e.g. EF1a promoters). The TRAC locus reported the highest GFP MFI. There was comparable expression between weeks 3 and 4. The results also showed most top loci have more than 1 sgRNA. With regard to KI efficiency, the SOCS1 locus reported the highest KI efficiency. Overall, KI efficiency showed less variation when driven by the exogenous promoters than when driven by endogenous promoters.

FIGS. 31A, 31B, and 31C show GFP MFI and KI efficiency for all significant loci having endogenous and exogenous (e.g., EF1a) promoters. The results showed that expression driven by EF1a promoters is about 10× higher than endogenous promoters (FIG. 31A). With regard to KI efficiency, the SOCS1 locus reported the highest KI efficiency. At weeks 3 and 4, KI efficiency was higher when driven by the exogenous promoters than when driven by endogenous promoters.

Example 5: Evaluation of TCR Expression in Candidate Noncoding Sites

This experiment was conducted to identify target loci and integration sites that enable high transgene expression without disrupting the TCR. Some gene deserts (e.g. gene deserts 2, 3, 5, and 6) were identified as having high transgene expression (FIG. 32A).

To evaluate and identify preferred knock-in sites, TCR expression was measured following circuit cassette knock in of PrimeR (Prime Receptor (Myc)). Myc denotes an N-terminal Myc epitope tag to facilate detection of surface expressed primer receptor. Briefly, CD3-CD28 Dynabead-activated T cells were electroporated with sgRNA/Cas9 RNPs targeting the indicated sites (see FIGS. 32B and 33A), as well as HDRTs with homology arms directing HDR-mediated integration into the indicated sites. At day 6 post-electroporation, cells were stained with anti-TCRalpha/beta and anti-myc antibodies and analyzed on an Attune NxT flow cytometer. As shown in FIG. 32B, the TCR expression was maintained at GS94 and GS102 candidate integration (knock-in) sites. Only ⅔ of the cells that had circuit cassette knock in of PrimeR at GS79 (TRAC) locus maintained TCR expression. These results indicated that the GS94 and GS102 sites showed better potential for TCR stimulation.

The percentage of cells showing effective knock-in (based on measurements of PrimeR) was 36%±4% when using the GS94 integration site, as compared to 32%±5% when using the TRAC integration site. These results revealed integration sites, including GS94, that supported reproducibly high circuit cassette knockin rates. See FIG. 33A.

Example 6: Evaluation of GS94 Circuit Expression and Function

GS94 is a candidate integration site located on chromosome 11's distal q arm. It is within 180-350 kb of the promoters for ETS1 and FLI1 (FIG. 33B), however that is considered low-risk for integration vector gene therapy. The circuit expression and function potential of the GS94 gene was evaluated.

T cells underwent circuit cassette integration with PrimeR at GS79 (TRAC) integration site and GS94 integration site. The cells were cocultured with K562 C19 cells for 48 hours and then the PrimeR induced CAR MFI was compared to the PrimeR MFI.

Briefly, T cells generated as described in the Example above were cocultured with K562 CD19+/MSLN− cells at day 7 post-electroporation. MSLN (mesothelin) is a gene that is overexpressed in human pancreatic cancer. Cells were then stained with anti-FLAG antibody 48 h post initiation of coculture and analyzed on an Attune NxT flow cytometer. The results revealed that GS94 yields superior CAR induction with high prime R expression following the 48-hour coculture with the K562 C19 cells. See FIG. 34A. GS94 resulted in prime antigen-dependent CAR expression that was approximately two-fold higher than the expression in several other candidate integration sites as well as the TRAC integration site. Additionally, on average, the prime receptor surface expression level was no less than 50% of expression level when using the TRAC integration site.

Cytotoxicity and Cytokine Secretion

To evaluate the effect of the candidate integration site on cytotoxicity and cytokine secretion, T cells that had undergone circuit cassette integration with PrimeR at GS79 (TRAC) integration site and GS94 integration site were cocultured with K562 C19/MSLN cells for 48 hours. MSLN is a gene that is overexpressed in human pancreatic cancer. The cells were treated at a 1:1 effector:target cell ratio (1:1 E:T)). Briefly, T cells generated as described above were cocultured with K562 CD19+/MSLN+ cells at day 7 post-electroporation. 48 h post initiation of coculture, supernatants were collected and analyzed via Luminex® for cytokine levels. The cytokines measure were IL-2, INFg, and TNF. Cytotoxicity was analyzed by measuring luciferase activity of remaining target cells after 48 h. Each of the data points in FIG. 34B represent two replicates and the lines represent the range of cytotoxicity for the replicates. As shown in FIG. 34B, the GS94 integration sites resulted in superior cycotoxic ability and cytokine secretion following the 48-hour coculture with K562 C19/MSLN cells.

Prime-Independent Cytotoxicity

To compare the effect of the candidate integration site on cytotoxicity versus prime-independent cytotoxicity, T cells that had undergone circuit cassette integration with PrimeR at GS79 (TRAC) integration site and GS94 integration site were cocultured with K562 CD19+/MSLN+ cells or K562 CD19−/MSLN+ cells (“K562 MSLN”) at day 7 post-electroporation for 48 hours. 0.3, 1.0, and 3.0 E:T cell ratios were tested. See FIG. 35A and FIG. 35B. At 48 h post initiation of coculture, cytotoxicity was analyzed by measuring luciferase activity of remaining target cells As shown in FIG. 35B, the GS94 integration site resulted in equivalent cytotoxic potential to the TRAC integration site and there was no prime-independent cytotoxicity.

Prime-Independent Cytokine Section

To compare the effect of the candidate integration site on cytoxicity versus prime-independent cytotoxicity, T cells that had undergone circuit cassette integration with PrimeR at GS79 (TRAC) integration site and GS94 integration site, generated as described above, were cocultured with K562 CD19+/MSLN+ cells. A group that had target cells only (E:T=0; Targets only) was compared to a group with an E:T cell ratio of 1. Following the 48 h coculture with the K562 CD19+/MSLN+ cells, supernatant was collected and analyzed via Luminex® for cytokine levels to measure secretion of IL-2, INFg and TNF cytokines. See FIG. 36A and FIG. 36B. As shown in FIG. 36B, the GS94 integration site resulted in equivalent cytokine secretion to the TRAC integration site and there was no prime-independent secretion of IL-2, INFg or TNF.

Prime-Independent CAR Expression

To evaluate the effect of the candidate integration site on prime-independent CAR expression, T cells that had undergone circuit cassette integration with PrimeR at GS79 (TRAC) integration site, GS94 integration site, and GS102 integration site were cultured in vitro for 32 days. The cells were treated with repetitive CD3/CD28 stimulation at days 5, 12, 19 and 28 of the experiment. On Day 16, the cells were evaluated for CAR expression using a flow cytometry assay. As shown in FIG. 37, T cell activation through TCR did not result in prime R-independent CAR expression from circuit cassette integration at the candidate integration sites.

T cells generated as described above were cultured in 96-well plates, with T cell growth medium being exchanged every 2 days. At days 5, 12, 19 and 28, T cells were stimulated with 1:1 CD3/CD28 Dynabeads. Cells were analyzed for PrimeR expression by myc epitope tag staining, and for CAR expression by FLAG epitope tag staining at the indicated time points. Flow analysis was performed on an Attune NxT flow cytometer.

Example 7: Evaluating Stability of Prime Receptor Expression Over Several Weeks

To evaluate the effect of the candidate integration sites on stable (sustained) expression of PrimeR, T cells that had undergone circuit cassette integration with PrimeR at the integration sites indicated in FIG. 38 were cultured in vitro for 32 days. Briefly, T cells generated as described above were cultured in 96-well plates, with T cell growth medium being exchanged every 2 days. At days 5, 12, 19 and 28, T cells were stimulated with 1:1 CD3/CD28 Dynabeads repetitive stimulation. Flow cytometry assays were run on days 16 and 32 using an Attune NxT flow cytometer. The cells were analyzed for PrimeR expression by myc epitope tag staining. As shown in FIGS. 38A and 38B, the GS94 integration site resulted in stable PrimeR expression over at least a 4-week period.

Example 8: Evaluation of On-Target Editing Efficiency

To evaluate the on-target editing efficiency of candidate knock-in sites, iGUIDE-Seq assay was used. The methods used for conducting the iGUIDE-Seq assay are illustrated in FIG. 39A and provided in Nobles et al., Genome Biology (2019), which is hereby incorporated by reference in its entirety. As shown in FIG. 39B, the GS94 integration site had the highest on-target editing efficiency of the evaluated candidate integration sites. As shown in FIG. 39C, GS94 resulted in no putative off-target editing as observed with two donors.

Example 9: Evaluation of GS94 Knock-In
Methods

Elevation prediction: Computational predictions of potential off-target sites from (gs94) were performed using Elevation-search (algorithm described in Listgarten et al. 2018. Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs. Nat Biomed Engr 2, 37-48; software obtained from github.com/Microsoft/Elevation). All sites identified by Elevation-search were subjected to analysis using rhAmp-seg™.

rhAmpSeg™: 49 candidate off-target sites for GS94 identified by iGUIDE or the Elevation prediction algorithm and the GS94 target site were characterized by rhAmpSeg™ (Integrated DNA Technologies, Inc.). This targeted amplification enables NGS-based quantification of the editing occurring at numerous sites simultaneously. Genomic DNA from T cells from at least 2 donors that had been treated singly with each of the following 7 guides: GS84, GS94, GS95, GS96, GS102, GS108, and GS138 was isolated with the GenFind® V3 DNA purification system (Beckman Coulter). Two separate rhAmpSeg™ amplification pools were used to cover the 50 loci, the procedure was performed as recommended by Integrated DNA Technologies for each of the samples. The rhAmpSeg™ libraries were sequenced on a MiniSeg™ with a Mid Output Kit (300-cycles) (Illumina). The CRISPResso2 algorithm (github.com/pinellolab/CRISPResso2) was used to determine the percentage of insertions and deletions at each of the amplified loci. Statistical significance (FDR-adjusted p-value≤0.001) using a chi-squared test was only observed at the GS94 site.

RNA-seq: To evaluate changes induced by GS94 integration at the transcriptional level, a CD19/MSLN circuit was integrated at the GS79 (TRAC), GS94, and GS102 integration sites. On day 6 post-integration, 1e6 edited cells were sorted using a BD FACSAria based on transgene expression. RNA was isolated from sorted T cells with the RNeasy kit (Qiagen). Purified RNA was converted into an NGS library using the TruSeq™ RNA Library Prep Kit v2 (Illumina). Libraries were sequenced on either the NovaSeq™ 6000 or NextSeq™ 550 instruments (Illumina). The STAR 2.7.3a aligner (Dobin A. et al. Bioinformatics. 2013. 29:15-21) was used to align the RNA-seq data against the reference human GRCh38 transcriptome and to obtain gene-level read counts. edgeR (Robinson M D et al. Bioinformatics. 2010. 26: 139-140) was used to compute differential expression, combining data across both donors. The only genes within 300 Kb of the GS94 site, ETS1 and FLI1, were not differentially expressed in cells with integration at the GS94 integration site compared to cells with integration at any of the other two loci. At an FDR-adjusted p-value cutoff of 0.01, the number of differentially expressed genes was minimal (<100 genes genome-wide).

Cytokine-independent growth assay: To evaluate the safety of the primary T cells with GS94 locus KI, cytokine-independent growth assay was performed to evaluate the potential for oncogenic transformation. Briefly, primary human T cells that had undergone CD19/MSLN circuit cassette integration at GS94 locus were thawed and recovered overnight. 1×10⁶cells were then seeded in one well of a 24 well-GRex plate, culturing for 5 days in the medium with or without cytokines. Cell number and viability were recorded at days 0, 3 and 5. As a positive control, 1×10⁶Jurkat cells were cultured in the medium without cytokines in parallel. As shown in FIG. 43, while GS94 KI T cells maintained good viability and total cell count when cultured with cytokine, the viability of GS94 KI T cells drastically decreased over the course of 5 days when cultured without cytokine and there was no viable cell left on day 5. The positive control Jurkat cells maintained good viability and expansion without cytokine throughout the assay. Taken together, this data shows that GS94 edited primary human T cells still depend on exogenous cytokine for growth, survival and expansion, therefore, there is no concern for cellular transformation.

Results

The specificity of CRISPR reagents (e.g. SpCas9 complexed with sgRNA) targeting candidate loci including GS94 was evaluated by iGUIDE-seq (FIG. 40). GS94-targeting CRISPR RNP showed the highest percentage of iGUIDE-seq oligo cassette trapping events of all candidates evaluated, and the control sgRNA sequences from the iGUIDE-seq paper showed similar specificities to what was reported in the original publication, suggesting that the assay performed as expected.

Putative off-target sites were taken from the iGUIDE-seq output, which already suggested that the putative sites were spurious. Additional target sites were predicted by a computational approach (Elevation software package). rhAmp-seg™ was used to prepare high-throughput sequencing libraries for each of the putative off-target sites, and the method was applied to DNA samples from T cells electroporated with CRISPR RNPs targeting the candidate target sites. The resulting NGS data were processed with CRISPResso2 software, and the frequency of insertions and deletions (indels) was taken as indication of CRISPR cleavage activity, as is common in the field. T cells electroporated with GS94-targeting CRISPR RNP showed no greater frequency of indels at the set of putative off-target sites than T cells treated with CRISPR RNP targeting other sites, consistent with the GS94-targeting CRISPR RNP having no consequential or detectable off-target activity, and therefore being the most specific out of the set evaluated (FIG. 41).

Potential effects of transgene integration at the GS94 site on the regulation of the T cell transcriptome were evaluated by knocking in a large cassette to the site, growing T cells for several days, sorting cells expressing the transgene within the cassette, and then collecting RNA from the cells. RNA-seq libraries were prepared and sequenced, and analysis of the resulting Illumina sequencing data revealed no biologically or statistically significant differences in expression of any genes within 300 kb of the GS94 site in cells with integrations at GS94 compared to cells with integration at TRAC or the GS102 sites (FIG. 42). Furthermore, other gene expression differences that reached statistical significance were minimal in number and in effect size, consistent with them being noise in the comparison.

To assess whether transgene integration at GS94 could confer a transformed phenotype, cells with integrations at the GS94 site were cultured with and without cytokines in vitro. Cells remained alive and viable with cytokine addition, but died without cytokine supplementation and lost their viability (FIG. 43). The positive control Jurkat cells remained viable and proliferated. Overall, this indicates that integration of a transgene at GS94 does not confer capacity for cytokine-independent growth, which is a hallmark of T cell transformation.

Example 10: In Vivo Insertion of a CAR Expressing Cassette

In vivo efficacy of T cells with a transgene cassette expressing a CAR recognizing a tumor antigen, or a CAR recognizing a tumor antigen under control of a priming receptor recognizing an antigen in the anatomical vicinity of the tumor, is assessed against human tumor cells such as K562 engineered to express the CAR antigen or to express antigens recognized by both the priming receptor and the CAR. Tumor cells (e.g. 1e6) are subcutaneously injected into the flank of NSG mice (Jackson Laboratories). Tumor growth is assessed by dimensional measurement by calipers every 2-4 days. When the tumor volume reaches ˜100 cubic mm, mice are intravenously injected with 5e6 T cells with a CAR or prime-CAR circuit cassette integrated at a specific site by CRISPR-mediated insertion, or with T cells engineered with CRISPR RNP alone, or with PBS alone as a sham injection. Tumor growth is monitored and mice are euthanized when tumor volume reaches 2000 cubic mm. Peripheral blood is bled from mice through a retro-orbital procedure, and flow cytometry and/or ddPCR is used to observe engineered T cell expansion over time. At time of sacrifice, spleen, blood, tumor and/or other tissue is analyzed via flow cytometry, ddPCR, and/or immunohistochemistry for the presence of engineered T cells. The results demonstrate that T cells engineered with cassette integration at one of the defined genomic loci lead to tumor regression and clearance in injected mice as compared to T cells without cassette integration, and that engineered T cells are detectable in the peripheral blood and tissues of injected mice.

REFERENCES

Eyquem, J., Mansilla-Soto, J., Giavridis, T., van der Stegen, S. J Hamieh, M., Cunanan, K. M., . . . & Sadelain, M. (2017). Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection. Nature, 543(7643), 113-117.

Sadelain, M., Papapetrou, E. P., & Bushman, F. D. (2012). Safe harbours for the integration of new DNA in the human genome. Nature reviews Cancer, 12(1), 51-58.

Irion, S., Luche, H., Gadue, P., Fehling, H. J., Kennedy, M., & Keller, G. (2007). Identification and targeting of the ROSA26 locus in human embryonic stem cells. Nature biotechnology, 25(12), 1477-1482.

Pellenz, S., Phelps, M., Tang, W., Hovde, B. T., Sinit, R. B., Fu, W., . . . & Monnat Jr, R. J. (2019). New human chromosomal sites with “safe harbor” potential for targeted transgene insertion. Human gene therapy, 30(7), 814-828.

Roth, T. L., Li, P. J., Nies, J. F., Yu, R., Nguyen, M. L., Lee, Y., . . . & Nguyen, D. N. (2019). Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits. bioRxiv, 604561.

TABLE 4

SGRNA SEQUENCES USED FOR EVALUATION OF PREDICTED LOCI

Median (%

Modified),

sgRNA_

summarized

start_
sgRNA
Integra-
from 2

sgRNA

coor
Target
tion
donors, 2

ID
sgRNA Sequence
GRCH38
Loci
Site
primersets

sgRNA_
GCACCTGAATACCACGCCTG
chr16:
APRT
APRT
79.28

1
(SEQ ID NO: 1)
88811818

sgRNA_
CGCCTGCGATGTAGTCGATG
chr16:
APRT
APRT
78.60

2
(SEQ ID NO: 2)
88811551

sgRNA_
CAGGACGGGCGAGATGTCCC
chr16:
APRT
APRT
85.25

3
(SEQ ID NO: 3)
88811640

sgRNA_
CTGAATCTTTGGAGTACCTG
chr15:
B2M
B2M
78.51

4
(SEQ ID NO: 4)
44715425

sgRNA_
GGCCACGGAGCGAGACATCT
chr15:
B2M
B2M
94.75

5
(SEQ ID NO: 5)
44711550

sgRNA_
AAGTCAACTTCAATGTCGGA
chr15:
B2M
B2M
70.97

6
(SEQ ID NO: 6)
44715515

sgRNA_
GCTTGGAGGCCTGATCAGCG
chr19:
CAPNS1
CAPNS1
89.34

7
(SEQ ID NO: 7)
36141111

sgRNA_
CTTATCTCTTCGCAGCGAGG
chr19:
CAPNS1
CAPNS1
91.09

8
(SEQ ID NO: 8)
36142301

sgRNA_
CACACATTACTCCAACATTG
chr19:
CAPNS1
CAPNS1
71.98

9
(SEQ ID NO: 9)
36142676

sgRNA_
TTCCGCAAAATAGAGCCCCA
chr3:
CBLB
CBLB
91.55

10
(SEQ ID NO: 10)
105746019

sgRNA_
TGCACAGAACTATCGTACCA
chr3:
CBLB
CBLB
91.43

11
(SEQ ID NO: 11)
105751622

sgRNA_
GCAATAAGACTCTTTAAAGA
chr3:
CBLB
CBLB
76.18

12
(SEQ ID NO: 12)
105853470

sgRNA_
CAAAGAGATTACGAATGCCT
chr1:
CD2
CD2
89.80

13
(SEQ ID NO: 13)
116754658

sgRNA_
CAAGGCACCCCAGGTTTCCA
chr1:
CD2
CD2
92.70

14
(SEQ ID NO: 14)
116754663

sgRNA_
TTACGAATGCCTTGGAAACC
chr1:
CD2
CD2
92.82

15
(SEQ ID NO: 15)
116754666

sgRNA_
CAGAGACGCATCTGACCCTC
chr11:
CD3E
CD3E
90.96

16
(SEQ ID NO: 16)
118315540

sgRNA_
CATGCAGTTCTCACACACTG
chr11:
CD3E
CD3E
87.47

17
(SEQ ID NO: 17)
118313715

sgRNA_
GTGTGAGAACTGCATGGAGA
chr11:
CD3E
CD3E
86.65

18
(SEQ ID NO: 18)
118313715

sgRNA_
TCTCATTTCAGGAAACCACT
chr11:
CD3G
CD3G
87.24

19
(SEQ ID NO: 19)
118349748

sgRNA_
AGTCATACACCTTAACCAAG
chr11:
CD3G
CD3G
87.99

20
(SEQ ID NO: 20)
118349754

sgRNA_
TTCAAGGAAACCAGTTGAGG
chr11:
CD3G
CD3G
86.55

21
(SEQ ID NO: 21)
118352458

sgRNA_
GAGCCTTGCCTGGAAATCTG
chr11:
CD5
CD5
84.03

22
(SEQ ID NO: 22)
61118177

sgRNA_
AAGCGTCAAAAGTCTGCCAG
chr11:
CD5
CD5
89.19

23
(SEQ ID NO: 23)
61118324

sgRNA_
CGTTCCAACTCGAAGTGCCA
chr11:
CD5
CD5
83.11

24
(SEQ ID NO: 24)
61118121

sgRNA_
GAGCGACTGGGACACGGTGA
chr9:
EDF1
EDF1
88.84

25
(SEQ ID NO: 25)
136866246

sgRNA_
GCTGCGCAAGAAGGGCCCTA
chr9:
EDF1
EDF1
91.04

26
(SEQ ID NO: 26)
136866211

sgRNA_
TTGTTCTGGCCAGCAGCCCC
chr9:
EDF1
EDF1
85.98

27
(SEQ ID NO: 27)
136863433

sgRNA_
CTTCCAGAGCCACATCATCG
chr19:
FTL
FTL
93.10

28
(SEQ ID NO: 28)
48965791

sgRNA_
GGGACTCACCAGAGAGAGGT
chr19:
FTL
FTL
88.86

29
(SEQ ID NO: 29)
48965601

sgRNA_
CGGTCGAAATAGAAGCCCTA
chr19:
FTL
FTL
93.14

30
(SEQ ID NO: 30)
48965770

sgRNA_
AAAAGGATATTGTGCAACTG
chr10:
PTEN
PTEN
92.37

31
(SEQ ID NO: 31)
87933015

sgRNA_
TGTGCATATTTATTACATCG
chr10:
PTEN
PTEN
90.64

32
(SEQ ID NO: 32)
87933183

sgRNA_
TTTGTGAAGATCTTGACCAA
chr10:
PTEN
PTEN
85.36

33
(SEQ ID NO: 33)
87933087

sgRNA_
TGTCATGCTGAACCGCATTG
chr18:
PTPN2
PTPN2
87.94

34
(SEQ ID NO: 34)
12830972

sgRNA_
CCACTCTATGAGGATAGTCA
chr18:
PTPN2
PTPN2
92.45

35
(SEQ ID NO: 35)
12859219

sgRNA_
TTGACATAGAAGAGGCACAA
chr18:
PTPN2
PTPN2
93.96

36
(SEQ ID NO: 36)
12836828

sgRNA_
GAGTACTACACTCAGCAGCA
chr12:
PTPN6
PTPN6
89.61

37
(SEQ ID NO: 37)
6952098

sgRNA_
TCACGCACAAGAAACGTCCA
chr12:
PTPN6
PTPN6
82.74

38
(SEQ ID NO: 38)
6954872

sgRNA_
AGGTCTCGGTGAAACCACCT
chr12:
PTPN6
PTPN6
91.27

39
(SEQ ID NO: 39)
6951610

sgRNA_
AGCATTATCCAAAGAGTCCG
chr1:
PTPRC
PTPRC
88.88

40
(SEQ ID NO: 40)
198696873

sgRNA_
ATATTAATTCTTACCAGTGG
chr1:
PTPRC
PTPRC
88.95

41
(SEQ ID NO: 41)
198692370

sgRNA_
AGCTTTAAATCAAGGTTCAT
chr1:
PTPRC
PTPRC
96.89

42
(SEQ ID NO: 42)
198756176

sgRNA_
ATCCCGAGCCCTAAGGTGCA
chr11:
PTPRCAP
PTPRCA
84.08

43
(SEQ ID NO: 43)
67436325

P

sgRNA_
GGCAGCGCGGAGGACAGCGT
chr11:
PTPRCAP
PTPRCA
97.74

44
(SEQ ID NO: 44)
67436285

P

sgRNA_
CTCAGGGGGCTACTACCACC
chr11:
PTPRCAP
PTPRCA
91.50

45
(SEQ ID NO: 45)
67436170

P

sgRNA_
GTCACCGACGAGACCAGAAG
chr5:
RPS23
RPS23
79.40

46
(SEQ ID NO: 46)
82277810

sgRNA_
GTCGTGGACTTCGTACTGCT
chr5:
RPS23
RPS23
83.07

47
(SEQ ID NO: 47)
82277843

sgRNA_
TAATTTTTAGGCAAGTGTCG
chr5:
RPS23
RPS23
61.94

48
(SEQ ID NO: 48)
82277860

sgRNA_
TTAGCTGTTAGACTTGAATA
chr14:
RTRAF
RTRAF
85.50

49
(SEQ ID NO: 49)
51993810

sgRNA_
CGAGAGCCGTCAACTTGCGT
chr14:
RTRAF
RTRAF
85.64

50
(SEQ ID NO: 50)
51989652

sgRNA_
CGGCTTCAACTGCAAAGGTG
chr14:
RTRAF
RTRAF
88.77

51
(SEQ ID NO: 51)
51989700

sgRNA_
TATGAAAAAGCAGAGCGACT
chr15:
SERF2
SERF2
89.61

52
(SEQ ID NO: 52)
43793025

sgRNA_
TCTGGCGGGCGAGCTCACGC
chr15:
SERF2
SERF2
86.73

53
(SEQ ID NO: 53)
43792989

sgRNA_
CTCACGCTGGTTACCGCCTA
chr15:
SERF2
SERF2
80.57

54
(SEQ ID NO: 54)
43792977

sgRNA_
AAAGATTACGAACTTCCCTG
chr12:
SLC38A1
SLC38A1
92.24

55
(SEQ ID NO: 55)
46207559

sgRNA_
GTTAAAAACAGACATGCCTA
chr12:
SLC38A1
SLC38A1
91.51

56
(SEQ ID NO: 56)
46229232

sgRNA_
ATGCCTAAGGAGGTTGTACC
chr12:
SLC38A1
SLC38A1
79.48

57
(SEQ ID NO: 57)
46229246

sgRNA_
CTCCAGGTATCCCATCGAAA
chr18:
SMAD2
SMAD2
79.53

58
(SEQ ID NO: 58)
47869418

sgRNA_
CACCAAATACGATAGATCAG
chr18:
SMAD2
SMAD2
86.61

59
(SEQ ID NO: 59)
47870532

sgRNA_
TGGCGGCGTGAATGGCAAGA
chr18:
SMAD2
SMAD2
82.91

60
(SEQ ID NO: 60)
47896729

sgRNA_
TAGGATGGTAGCACACAACC
chr16:
SOCS1
SOCS1
92.25

61
(SEQ ID NO: 61)
11255478

sgRNA_
CAGCAGCAGAGCCCCGACGG
chr16:
SOCS1
SOCS1
83.79

62
(SEQ ID NO: 62)
11255432

sgRNA_
CGGCGTGCGAACGGAATGTG
chr16:
SOCS1
SOCS1
84.24

63
(SEQ ID NO: 63)
11255296

sgRNA_
TATAGACGCTGCCCGACGTC
chr15:
SRP14
SRP14
95.12

64
(SEQ ID NO: 64)
40038895

sgRNA_
TCCAAAGAAGGGTACTGTGG
chr15:
SRP14
SRP14
92.14

65
(SEQ ID NO: 65)
40038368

sgRNA_
ACAGTACCCTTCTTTGGAAT
chr15:
SRP14
SRP14
65.82

66
(SEQ ID NO: 66)
40038358

sgRNA_
GCGACGGGCGCATCTACGTG
chr12:
SRSF9
SRSF9
83.68

67
(SEQ ID NO: 67)
120469572

sgRNA_
CCCGACCTCCATAAGTCCTG
chr12:
SRSF9
SRSF9
92.56

68
(SEQ ID NO: 68)
120465700

sgRNA_
GGGGTCCTCGAAGCGCACGA
chr12:
SRSF9
SRSF9
89.94

69
(SEQ ID NO: 69)
120469426

sgRNA_
TGCTCTGTTTAGAAGATGAC
chr5:
SUB1
SUB1
79.36

70
(SEQ ID NO: 70)
32591641

sgRNA_
ATATTCTTTTCTAGTTAAAG
chr5:
SUB1
SUB1
70.93

71
(SEQ ID NO: 71)
32591566

sgRNA_
CCTGTAAAGAAACAAAAGAC
chr5:
SUB1
SUB1
93.66

72
(SEQ ID NO: 72)
32591614

sgRNA_
TGGAGAAAGACGTAACTTCG
chr4:
TET2
TET2
83.53

73
(SEQ ID NO: 73)
105234315

sgRNA_
TCTGCCCTGAGGTATGCGAT
chr4:
TET2
TET2
90.97

74
(SEQ ID NO: 74)
105234747

sgRNA_
ATTCCGCTTGGTGAAAACGA
chr4:
TET2
TET2
89.62

75
(SEQ ID NO: 75)
105235656

sgRNA_
CAGGCACAATAGAAACAACG
chr3:
TIGIT
TIGIT
92.65

76
(SEQ ID NO: 76)
114295571

sgRNA_
CCATTTGTAATGCTGACTTG
chr3:
TIGIT
TIGIT
60.75

77
(SEQ ID NO: 77)
114295700

sgRNA_
CTGGGTCACTTGTGCCGTGG
chr3:
TIGIT
TIGIT
87.99

78
(SEQ ID NO: 78)
114295634

sgRNA_
GTCAGGGTTCTGGATATCTG
chr14:
TRAC
TRAC
98.20

79
(SEQ ID NO: 79)
22547508

sgRNA_
TGGATTTAGAGTCTCTCAGC
chr14:
TRAC
TRAC
88.15

80
(SEQ ID NO: 80)
22547541

sgRNA_
CTGCGGCTGTGGTCCAGCTG
chr14:
TRAC
TRAC
94.77

81
(SEQ ID NO: 81)
22550661

sgRNA_
ACAAAACTGTGCTAGACATG
chr14:
TRAC
TRAC
87.86

82
(SEQ ID NO: 82)
22547658

sgRNA_
TTCTTCCCCAGCCCAGGTAA
chr14:
TRAC
TRAC
89.85

83
(SEQ ID NO: 83)
22547778

sgRNA_
CGTCATGAGCAGATTAAACC
chr14:
TRAC
TRAC
95.81

84
(SEQ ID NO: 84)
22550625

sgRNA_
GAGAGCGCCTGCGACCCGAG
chr19:
TRIM28
TRIM28
89.44

85
(SEQ ID NO: 85)
58544980

sgRNA_
CCAGCGGGTGAAGTACACCA
chr19:
TRIM28
TRIM28
94.79

86
(SEQ ID NO: 86)
58544869

sgRNA_
GGAGCGCTTTTCGCCGCCAG
chr19:
TRIM28
TRIM28
91.81

87
(SEQ ID NO: 87)
58544839

sgRNA_
TGAGGCCTGGACCTTATGCA
chr10:
chr10:
desert_
69.44

88
(SEQ ID NO: 88)
33134193
33130000-
1

33140000
(GS88)

sgRNA_
CCTGGTGGAGTGAACCATGA
chr10:
chr10:
desert_
95.25

89
(SEQ ID NO: 89)
33132917
33130000-
1

33140000
(GS89)

sgRNA_
CAAGCACTTAGGTTCCCCTG
chr10:
chr10:
desert_
91.13

90
(SEQ ID NO: 90)
33134633
33130000-
1

33140000
(GS90)

sgRNA_
GGTCTCCCTACAATTCAGCG
chr10:
chr10:
desert_
92.02

91
(SEQ ID NO: 91)
72294568
72290000-
2

72300000
(GS91)

sgRNA_
CACAGCGCGTGACTGCAATG
chr10:
chr10:
desert_
90.22

92
(SEQ ID NO: 92)
72298268
72290000-
2

72300000
(GS92)

sgRNA_
TCTGGGGCACCAATTCTAGG
chr10:
chr10:
desert_
86.35

93
(SEQ ID NO: 93)
72292786
72290000-
2

72300000
(GS93)

sgRNA_
GAGCCATGCTTGGCTTACGA
chr11:
chr11:
desert_
91.24

94
(SEQ ID NO: 94)
128342576
128340000-
3

128350000
(GS94)

sgRNA_
GTACAAGTACTTATCTCATG
chr11:
chr11:
desert_
89.02

95
(SEQ ID NO: 95)
128343592
128340000-
3

128350000
(GS95)

sgRNA_
GAGATAACAACATAACAACA
chr11:
chr11:
desert_
96.47

96
(SEQ ID NO: 96)
128347170
128340000-
3

128350000
(GS96)

sgRNA_
CATATTCCATAGTCTTTGGG
chr11:
chr11:
desert_
88.54

97
(SEQ ID NO: 97)
65425000
65425000-
4

65427000
(GS97)

(NEAT1)

sgRNA_
CTGCCCCTTAGCAACTTAGG
chr11:
chr11:
desert_
92.76

98
(SEQ ID NO: 98)
65425507
65425000-
4

65427000
(GS98)

(NEAT1)

sgRNA_
TGTTTAAAAATATGTTGACA
chr11:
chr11:
desert_
90.76

99
(SEQ ID NO: 99)
65426264
65425000-
4

65427000
(GS99)

(NEAT1)

sgRNA_
CCAGGAATGGAAACTCACGC
chr15:
chr15:
desert_
87.84

100
(SEQ ID NO: 100)
92830315
92830000-
5

92840000
(GS100)

sgRNA_
GAGGCCGCTGAATTAACCCG
chr15:
chr15:
desert_
85.32

101
(SEQ ID NO: 101)
92831850
92830000-
5

92840000
(GS101)

sgRNA_
ATACACGCACACTTGCAGAA
chr15:
chr15:
desert_
99.92

102
(SEQ ID NO: 102)
92831131
92830000-
5

92840000
(GS102)

sgRNA_
GAGCAGACAGAAACCCAGGG
chr16:
chr16:
desert_
87.92

103
(SEQ ID NO: 103)
11225670
11220000-
6

11230000
(GS103)

sgRNA_
TGAGTCTCCAAACAGAACAG
chr16:
chr16:
desert_
88.53

104
(SEQ ID NO: 104)
11226284
11220000-
6

11230000
(GS104)

sgRNA_
TAATATCACTGACTTCACGG
chr16:
chr16:
desert_
87.65

105
(SEQ ID NO: 105)
11225029
11220000-
6

11230000
(GS105)

sgRNA_
TACACACAATGTAAGCAGCA
chr2:
chr2:
desert_
71.79

106
(SEQ ID NO: 106)
87467461
87460000-
7

87470000
(GS106)

sgRNA_
GGGAGCTCAATTCGAAACCA
chr2:
chr2:
desert_
65.89

107
(SEQ ID NO: 107)
87468809
87460000-
7

87470000
(GS107)

sgRNA_
TTGGACAGGTGAGACAGTCG
chr2:
chr2:
desert_
72.64

108
(SEQ ID NO: 108)
87467001
87460000-
7

87470000
(GS108)

sgRNA_
AAGCTCACTCAGATAGTGTG
chr3:
chr3:
desert_
76.89

109
(SEQ ID NO: 109)
186511316
186510000-
8

186520000
(GS109)

sgRNA_
CAGGAGAACCACCTTACACG
chr3:
chr3:
desert_
86.31

110
(SEQ ID NO: 110)
186515260
186510000-
8

186520000
(GS110)

sgRNA_
GGACAGACCCTGATTCACAA
chr3:
chr3:
desert_
85.47

111
(SEQ ID NO: 111)
186519655
186510000-
8

186520000
(GS111)

sgRNA_
ACATGGCAGTCTATGAACAG
chr3:
chr3:
desert_
87.77

112
(SEQ ID NO: 112)
59451154
59450000-
9

59460000
(GS112)

sgRNA_
CCTATAGAGAGTACTACTTG
chr3:
chr3:
desert_
79.33

113
(SEQ ID NO: 113)
59456416
59450000-
9

59460000
(GS113)

sgRNA_
CCAACCGGGTCTTCATTACG
chr3:
chr3:
desert_
92.21

114
(SEQ ID NO: 114)
59457029
59450000-
9

59460000
(GS114)

sgRNA_
TCAAGCGTAGAGTTCCGAGT
chr8:
chr8:
desert_
93.07

115
(SEQ ID NO: 115)
127993006
127980000-
10

128000000
(GS115)

sgRNA_
TCATGCAATTATGGACCCAG
chr8:
chr8:
desert_
89.40

116
(SEQ ID NO: 116)
127994663
127980000-
10

128000000
(GS116)

sgRNA_
CGGGAAAGTGACTGGCCATG
chr8:
chr8:
desert_
87.45

117
(SEQ ID NO: 117)
127996766
127980000-
10

128000000
(GS117)

sgRNA_
TGAGATTGAAATCAAATCGG
chr9:
chr9:
desert_
84.84

118
(SEQ ID NO: 118)
7974159
7970000-
11

7980000
(GS118)

sgRNA_
TATGCAATATTCATCACGCG
chr9:
chr9:
desert_
85.44

119
(SEQ ID NO: 119)
7977914
7970000-
11

7980000
(GS119)

sgRNA_
AATGTGTTAAATCAAATGCA
chr9:
chr9:
desert_
83.48

120
(SEQ ID NO: 120)
7976895
7970000-
11

7980000
(GS120)

TABLE 5

CONSTRUCTS USED FOR EVALUATION OF PREDICTED LOCI

Construct name
Sequence
Length

pARBI-903:
ATCTCGGCCAATAAAGGAGAAAGGGCGCGGCCCGTACGCGCGCCAGGTGC
1806

APRT_1_
GTGGGCGAGACCAGCTCACGCCCCTCCTCCAGCCGCCAAGGCCCCGGCCC

Endogenous_1
ACAGCTGCCTGGCTGCAGTCAGAAGCGTAGCCCGAGACAAGGAAGGGCGC

CTTGACTCGCACTTTTGTCCGGTTCGAACGTTCTGctcagtggtgcgtgg

aatgcgagcgcgtcttaaaatcgatggcgcctaggagtccatgaaatacg

gTACAGGCTTCCGGCGACGGATGCCCCGCCCCTCACCCACGCTCCGCCCT

CCGGGGATGCCCCACCCCTCGTGGCGGTCCCGCCCGTCCCCGCGCAGGCG

CGCTCGGGCTGCCGCTGGCTCTTCGCACGCGGCCATGGCCGACTCCGAGC

TGCAGCTGGTTGAGCAGCGGATCCGCAGCTTCCCCGACTTCCCCACCCCA

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatGGCGTGGTATTCAGGTGCACGCACAGGCCGCCCTCGTGGCGCCC

CGACCTGCGGGCCTACGGATGGGAGCGCGTGGCCCGCGACCTCCGGGCGG

GCGGGGGGGGAACCCTCGTCTTTCGCCCCCGGGGCCCTGCCCTCCTTCGG

CCCCGGCGTCACCAGGCCTGTCCTTGGGTCCAGGGACATCTCGCCCGTCC

TGAAGGACCCCGCCTCCTTCCGCGCCGCCATCGGCCTCCTGGCGCGACAC

CTGAAGGCGACCCACGGGGGCCGCATCGACTACATCGCAGGCGAGTGCCC

AGTGGCCGCATCTAGGGCGCTTCCGCCTCTGCGCGCGCCGAGGGCAGCAC

GTGGGCTCTGCGCGTCTGCTTGGGGGAGGGCCTTTGGGGTGCTTCAGGGG

GCGCCGGGACGGGCGCCGTGCTTGGGTCGCCCGGGAAGGGTTGTGAGATT

GAGCCC

(SEQ ID NO: 123)

pARBI-904:
TGCCCCGCCCCTCACCCACGCTCCGCCCTCCGGGGATGCCCCACCCCTCG
1806

APRT_2_
TGGCGGTCCCGCCCGTCCCCGCGCAGGCGCGCTCGGGCTGCCGCTGGCTC

Endogenous_2
TTCGCACGCGGCCATGGCCGACTCCGAGCTGCAGCTGGTTGAGCAGCGGA

TCCGCAGCTTCCCCGACTTCCCCACCCCAGGCGTGGTATTCAGGTGCACG

CACAGGCCGCCCTCGTGGCGCCCCGACCTGCGGGCCTACGGATGGGAGCG

CGTGGCCCGCGACCTCCGGGGGGGGGGGGCGGGAACCCTCGTCTTTCGCC

CCCGGGGCCCTGCCCTCCTTCGGCCCCGGCGTCACCAGGCCTGTCCTTGG

GTCCAGGGACATCTCGCCCGTCCTGAAGGACCCCGCCTCCTTCCGCGCCG

CCATCGGCCTCCTGGCGCGACACCTGAAGGCGACCCACGGGGGCCGCATC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatGACTACATCGCAGGCGAGTGCCCAGTGGCCGCATCTAGGGCGCT

TCCGCCTCTGCGCGCGCCGAGGGCAGCACGTGGGCTCTGCGCGTCTGCTT

GGGGGAGGGCCTTTGGGGTGCTTCAGGGGGCGCCGGGACGGGCGCCGTGC

TTGGGTCGCCCGGGAAGGGTTGTGAGATTGAGCCCCCGAGGCCGCCGCGC

TGTGCAGGCGTCCTTCCCGCAGGTTCCGGGTCCCCAGCCCAGGACAGGCG

TGACCGAGTTGCCGGGTCAGTTGGTCTCCCTGGAGTGCCCAAGCTGAATC

CACAGGGCCCAGCTGCCTTGCTTCTTGTTCCTTCTGCGAGCTGGTATTGA

GCGCCTGCCACGAGCCAGGCCTTCCCTGGTGAAGATCACGGAATGCCCAC

CCAGGGAAGGGAGGCCTGGAGGCCTCCGGGAGAGCCCAAGAGGTGGCCCA

GGGAGA

(SEQ ID NO: 124)

pARBI-905:
CGTTCTGctcagtggtgcgtggaatgcgagcgcgtcttaaaatcgatggc
1806

APRT_3_
gcctaggagtccatgaaatacggTACAGGCTTCCGGCGACGGATGCCCCG

Endogenous_3
CCCCTCACCCACGCTCCGCCCTCCGGGGATGCCCCACCCCTCGTGGCGGT

CCCGCCCGTCCCCGCGCAGGCGCGCTCGGGCTGCCGCTGGCTCTTCGCAC

GCGGCCATGGCCGACTCCGAGCTGCAGCTGGTTGAGCAGCGGATCCGCAG

CTTCCCCGACTTCCCCACCCCAGGCGTGGTATTCAGGTGCACGCACAGGC

CGCCCTCGTGGCGCCCCGACCTGCGGGCCTACGGATGGGAGCGCGTGGCC

CGCGACCTCCGGGCGGGCGGGGGGGGAACCCTCGTCTTTCGCCCCCGGGG

CCCTGCCCTCCTTCGGCCCCGGCGTCACCAGGCCTGTCCTTGGGTCCAGG

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatGACATCTCGCCCGTCCTGAAGGACCCCGCCTCCTTCCGCGCCGC

CATCGGCCTCCTGGCGCGACACCTGAAGGCGACCCACGGGGGCCGCATCG

ACTACATCGCAGGCGAGTGCCCAGTGGCCGCATCTAGGGCGCTTCCGCCT

CTGCGCGCGCCGAGGGCAGCACGTGGGCTCTGCGCGTCTGCTTGGGGGAG

GGCCTTTGGGGTGCTTCAGGGGGCGCCGGGACGGGCGCCGTGCTTGGGTC

GCCCGGGAAGGGTTGTGAGATTGAGCCCCCGAGGCCGCCGCGCTGTGCAG

GCGTCCTTCCCGCAGGTTCCGGGTCCCCAGCCCAGGACAGGCGTGACCGA

GTTGCCGGGTCAGTTGGTCTCCCTGGAGTGCCCAAGCTGAATCCACAGGG

CCCAGCTGCCTTGCTTCTTGTTCCTTCTGCGAGCTGGTATTGAGCGCCTG

CCACGA

(SEQ ID NO: 125)

pARBI-906:
AGTAATTTGATGGGGGCTATTATGAACTGAGAAATGAACTTTGAAAAGTA
1806

B2M_1_
TCTTGGGGCCAAATCATGTAGACTCTTGAGTGATGTGTTAAGGAATGCTA

Endogenous_4
TGAGTGCTGAGAGGGCATCAGAAGTCCTTGAGAGCCTCCAGAGAAAGGCT

CTTAAAAATGCAGCGCAATCTCCAGTGACAGAAGATACTGCTAGAAATCT

GCTAGAAAAAAAACAAAAAAGGCATGTATAGAGGAATTATGAGGGAAAGA

TACCAAGTCACGGTTTATTCTTCAAAATGGAGGTGGCTTGTTGGGAAGGT

GGAAGCTCATTTGGCCAGAGTGGAAATGGAATTGGGAGAAATCGATGACC

AAATGTAAACACTTGGTGCCTGATATAGCTTGACACCAAGTTAGCCCCAA

GTGAAATACCCTGGCAATATTAATGTGTCTTTTCCCGATATTCCTCAGGT

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGAATGG

AAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACA

TTGAAGTTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCAT

TCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACAC

TGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATG

TGACTTTGTCACAGCCCAAGATAGTTAAGTGGGGTAAGTCTTACATTCTT

TTGTAAGCTGCTGAAAGTTGTGTATGAGTAGTCATATCATAAAGCTGCTT

TGATATAAAAAAGGTCTATGGCCATACTACCCTGAATGAGTCCCATCCCA

TCTGATATAAACAATCTGCATATTGGGATTGTCAGGGAATGTTCTTAAAG

ATCAGA

(SEQ ID NO: 126)

pARBI-907:
AAGATCTTAATCTTCTGGGTTTCCGTTTTCTCGAATGAAAAATGCAGGTC
1806

B2M_2_
CGAGCAGTTAACTGGCTGGGGCACCATTAGCAAGTCACTTAGCATCTCTG

Endogenous_5
GGGCCAGTCTGCAAAGCGAGGGGGCAGCCTTAATGTGCCTCCAGCCTGAA

GTCCTAGAATGAGCGCCCGGTGTCCCAAGCTGGGGCGCGCACCCCAGATC

GGAGGGCGCCGATGTACAGACAGCAAACTCACCCAGTCTAGTGCATGCCT

TCTTAAACATCACGAGACTCTAAGAAAAGGAAACTGAAAACGGGAAAGTC

CCTCTCTCTAACCTGGCACTGCGTCGCTGGCTTGGAGACAGGTGACGGTC

CCTGCGGGCCTTGTCCTGATTGGCTGGGCACGCGTTTAATATAAGTGGAG

GCGTCGCGCTGGCGGGCATTCCTGAAGCTGACAGCATTCGGGCCGAGATG

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatTCTCGCTCCGTGGCCTTAGCTGTGCTCGCGCTACTCTCTCTTTC

TGGCCTGGAGGCTATCCAGCGTGAGTCTCTCCTACCCTCCCGCTCTGGTC

CTTCCTCTCCCGCTCTGCACCCTCTGTGGCCCTCGCTGTGCTCTCTCGCT

CCGTGACTTCCCTTCTCCAAGTTCTCCTTGGTGGCCCGCCGTGGGGCTAG

TCCAGGGCTGGATCTCGGGGAAGCGGGGGGTGGCCTGGGAGTGGGGAAGG

GGGTGCGCACCCGGGACGCGCGCTACTTGCCCCTTTCGGCGGGGAGCAGG

GGAGACCTTTGGCCTACGGCGACGGGAGGGTCGGGACAAAGTTTAGGGCG

TCGATAAGCGTCAGAGCGCCGAGGTTGGGGGAGGGTTTCTCTTCCGCTCT

TTCGCGGGGCCTCTGGCTCCCCCAGCGCAGCTGGAGTGGGGGACGGGTAG

GCTCG

(SEQ ID NO: 127)

pARBI-908:
AGGAATGCTATGAGTGCTGAGAGGGCATCAGAAGTCCTTGAGAGCCTCCA
1806

B2M_3_
GAGAAAGGCTCTTAAAAATGCAGCGCAATCTCCAGTGACAGAAGATACTG

Endogenous_6
CTAGAAATCTGCTAGAAAAAAAACAAAAAAGGCATGTATAGAGGAATTAT

GAGGGAAAGATACCAAGTCACGGTTTATTCTTCAAAATGGAGGTGGCTTG

TTGGGAAGGTGGAAGCTCATTTGGCCAGAGTGGAAATGGAATTGGGAGAA

ATCGATGACCAAATGTAAACACTTGGTGCCTGATATAGCTTGACACCAAG

TTAGCCCCAAGTGAAATACCCTGGCAATATTAATGTGTCTTTTCCCGATA

TTCCTCAGGTACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGA

ATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatGACATTGAAGTTGACTTACTGAAGAATGGAGAGAGAATTGAAAA

AGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCT

TGTACTACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGCCGT

GTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGGTAAGTC

TTACATTCTTTTGTAAGCTGCTGAAAGTTGTGTATGAGTAGTCATATCAT

AAAGCTGCTTTGATATAAAAAAGGTCTATGGCCATACTACCCTGAATGAG

TCCCATCCCATCTGATATAAACAATCTGCATATTGGGATTGTCAGGGAAT

GTTCTTAAAGATCAGATTAGTGGCACCTGCTGAGATACTGATGCACAGCA

TGGTTTCTGAACCAGTAGTTTCCCTGCAGTTGAGCAGGGAGCAGCAGCAG

CACTTG

(SEQ ID NO: 128)

pARBI-909:
GATCTCACATTCTAGCGCCCAGACATGTCGGGAACGCCTTACGCCAACTT
1806

CAPNS1_1_
GGGGTCCCCACCAAGAGAACCCCCACCAGATCTGCACCCTCCCCTTCACG

Endogenous_7
CGTGCACCCAGTCCAGGCTCCCTCAAGCCCCACGGGTGCCTTTTAGACCT

GAGGAGGTTGCAAACCTGATCCCCCATACCTGCCCCACCCATCCGCGGAC

AACCCGCCCTCGCAAACTCAGACCCCCACCCGGAGGCTTCAGATTCCTCC

CAGGTCCAGCTGCCGGAAATGCGTGTTTGAAGGGAGGGTGTGGGCTCAGG

GGCGAAGCACCCACTGGTCCCCTTTTTTCCCCCCAGCAGTGAGTCGCAGC

CATGTTCCTGGTTAACTCGTTCTTGAAGGGCGGCGGCGGCGGCGGCGGGG

GAGGCGGGGGCCTGGGTGGGGGCCTGGGAAATGTGCTTGGAGGCCTGATC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatAGCGGGGCCGGGGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGG

TGGTGGAGGCGGCGGTGGCGGTGGAACGGCCATGCGCATCCTAGGCGGAG

TCATCAGCGCCATCAGGTAAGGCGGAGACTATCAGAGGGGGGGGCCTGGG

AATGGGAGGAGCCTCAGTGAGGCGTGGTCTGGGAGGGGCGTGGTCTAAAA

ATAGAATAGGATTAACCTGGAGGCTAACCTGGGTACATGAATTAGGCCGG

GGAGGCCTGGTTTGAGAGTTCTGCTGTAAGGGGGTGGACCCCAGTGAGGC

GGATATCAGTCATTGGGGGCGGTGCTTGATATGGGAGTAGTCTGATTGTG

TGGGACCAGGACAATGTGGTCCTGAGGGGACTGATGTGGAGTTTTGGCGG

GTGGGGCTTATGGGTCTGGGCTCAGCCTGCATTGGCTAACCTGGAGATGA

ACGTT

(SEQ ID NO: 129)

pARBI-910:
CGGGCATTTAGGAAGCGGGCCATGGAGTAGGGTCTTGGGCAGATGGCACC
1806

CAPNS1_2_
TGAGGAGGATAAGGCCTTGGGAAGCTGGGGCAGAGCCTCTATGAAGTGAG

Endogenous_8
CCCTCCAAGGGGCGGGGTCTTTTGATTCTACGTGGGATTTTTTAGGTTTA

GGGTGGCCAAGATGACTGAAATCTGCCACTGGGTAGGTGTGCCTGGCAGG

AGGGGAGCCTCCCAGGGGACCGGTCTCTGGGTTTCCTCGAGGGTGGGGTT

GGCCTGAGGAAGGGAGAAGAGGGGCACGACCAGGGCAGTGTGGATTGGGA

CAGATGAGGACAAGAACAAATGAAAGGCACAGCAACCAAGTAAGGAAGAT

AACGGCTGGGGTCTGGAGCGTTGGGGCTGATGGTTCTGTAGTGCTGCCCG

TTGGAGGCCCCGCCCCTGGCACTAACCCCTCCCCCTTATCTCTTCGCAGC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatGAGGCGGCTGCGCAGTACAACCCGGAGCCCCCGGTAAGCCCCCT

CTGCAACCAGACCCCCTTCTCCTGCCAAGGCCTCTTCGAGGTCCCATCCC

TGTTCCTGTAGAGAAGCCCCACCTTCCTCCCCTTCTTGTGAAATTCCTCT

GCCAGTTCCTCCCATGCCGTGTCTGCAGCTTCGCCATGGGTCTTAGCCAT

GCCCCACATACGTGCACCCCATTCACTACCACCCCTCATTCTTTTCCTCA

TCAAGCTGCCCAGCCCACTCTGACTTCCCCACCCAGGGTACCTGGGTTTG

GGGAGCCGTCCTGGCCGGGTTCCCCTCCCCCTGCTCTGAGCTCTCCTCCC

TTTGCAGCCCCCACGCACACATTACTCCAACATTGAGGCCAACGAGAGTG

AGGAGGTCCGGCAGTTCCGGAGACTCTTTGCCCAGCTGGCTGGAGATGTA

AGTAAC

(SEQ ID NO: 130)

pARBI-911:
GCTGATGGTTCTGTAGTGCTGCCCGTTGGAGGCCCCGCCCCTGGCACTAA
1806

CAPNS1_3_
CCCCTCCCCCTTATCTCTTCGCAGCGAGGCGGCTGCGCAGTACAACCCGG

Endogenous_9
AGCCCCCGGTAAGCCCCCTCTGCAACCAGACCCCCTTCTCCTGCCAAGGC

CTCTTCGAGGTCCCATCCCTGTTCCTGTAGAGAAGCCCCACCTTCCTCCC

CTTCTTGTGAAATTCCTCTGCCAGTTCCTCCCATGCCGTGTCTGCAGCTT

CGCCATGGGTCTTAGCCATGCCCCACATACGTGCACCCCATTCACTACCA

CCCCTCATTCTTTTCCTCATCAAGCTGCCCAGCCCACTCTGACTTCCCCA

CCCAGGGTACCTGGGTTTGGGGAGCCGTCCTGGCCGGGTTCCCCTCCCCC

TGCTCTGAGCTCTCCTCCCTTTGCAGCCCCCACGCACACATTACTCCAAC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatATTGAGGCCAACGAGAGTGAGGAGGTCCGGCAGTTCCGGAGACT

CTTTGCCCAGCTGGCTGGAGATGTAAGTAACCTGGGGTCCCTGGCCCCGT

CCTAACCGTTCCATCCCTTCCCTTGTGGCTGCCCTTGCACACACACCCTT

GACCATGACAATCCCAGTGTTCCCATTCTCCATGACATTCTCAGACCCCT

TTCAGTCACCCCTGACCTGCCCCTAACTTCCGCCCGCAGGACATGGAGGT

CAGCGCCACAGAACTCATGAACATTCTCAATAAGGTTGTGACACGACGTA

AGTGACCGGGGTTAAGGAATAGGGTAGATTCAGAGGCAGAGGGGTCAGAG

AGGATTTGACCTCTGGCCTCTGACTTTCAACCTGTTACCCACAGACCCTG

ATCTGAAGACTGATGGTTTTGGCATTGACACATGTCGCAGCATGGTGGCC

GTGATG

(SEQ ID NO: 131)

pARBI-912:
ggagagttatagcagatggagacaaaaaagggaactgctggggatcaaac
1806

CBLB_1_
cttgtaaagtccttctaagtgatatatgaggactttgacttttattcaaa

Endogenous_10
gttagaaggctttgaacaaaagaattatttcatttgtgttttacaatggt

cacaagtgccgtagcgagaataggctgTGTAGAGAAGAGATTTTGTGGTT

TTCTTTTTTGTTCTCTGTATTCTCTTCCTGAAAAATCTGTTTTCTGCCTA

ATCATATTTCTGTAAAGAACAATAGACTTGAACGTCTGCTGTTAAGTAAC

AAAGGTTGACCTAAACCACATAAGGTCAGATTAACTTTTAAAATATCCAA

GATAATGTTAAGTGTATTAAATATGGTTCAGTATGTAATCAAAATATTTG

ATATTCTCTAGATACTAATCTCttttaatttttttattttttAGCCTTGG

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatGGCTCTATTTTGCGGAATTGGAATTTCTTAGCTGTGACACATCC

AGGTTACATGGCATTTCTCACATATGATGAAGTTAAAGCACGACTACAGA

AATATAGCACCAAACCCGGAAGGTAAGACTTTTTAGCAGTAATATTATGT

GATATATCCAAAGATGAAAAATTCTCCATGGTTTGTTCCTAAGTAAGTCA

GCAATACCCGCTGATGGCATGCTTGGGAGGGGGCTAGAAAAGGTAAAAGA

CCAAAATGGTGCTTCTTAACATAATGTTTTAAATTGATACATTGTGCTTA

CTCTGAAACTTGGTATTCATAAAGTGAAAGGGGATATGGTCTCCTTTCTG

TTTTCATGATATCCGTGTTTATGTGCAAAATTGAATGTATATATTTGAAT

ACTTGAATACTGTGCTAAAGAACAAATAAATAGAACAGTCTTATGTTCAT

TACTTT

(SEQ ID NO: 132)

pARBI-913:
CATATTACTCATTTGTGCAATGAATAAAGGATTTCTATTATTATATGGAC
1806

CBLB_2_
CCATCATCTTATGACTGTTTTTAGAAAATGAGAATTAAATCTTGATTCAT

Endogenous_11
TATTAAATAACCTTGTATACACACATGAAGAGGTCATGACACATAAGACT

TTGACCTAATACCTTTTTTCAGATATGTTTCTATAGCTATCTTGATAGCC

TAGGACTGTTTGAGAGAAAATTAATTTAAATTTTTGTCATATTCTTAGCA

AATGCAAAATAATTGAGTTAAACAGAACCCACTACATTTGTTCTGAAATA

TGAACAATATTCTCAAATATTTGTCTGGTAGTACAAATACAATTATATTA

ATTTTATTATTGAATTTTGCTGCTTCAAAGGGAGGTATTTCTTAAATGAT

ACTTGATTCAATTATTTCCCTTTTTTTCCACCTTGCACAGAACTATCGTA

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatCCATGGAAAGTATTCAGACAGTGCCTTCATGAGGTCCACCAGAT

TAGCTCTGGCCTGGAAGCAATGGCTCTAAAATCAACAATTGATTTAACTT

GCAATGATTACATTTCAGTTTTTGAATTTGATATTTTTACCAGGCTGTTT

CAGGTAAGTTTATACTTGCTTAGTCTATCCATTCCCTtcttctctctccc

tgtcttttctctctgtttctctctctctctgtctctctctcacacacaca

cacaTAAACAAACATATGGAAAATAGTGTCATTCCTATTAGTCTGTAATT

TTATTGGTATGTTTGGTCATTGTTAAAAGTTTAGAGTGAGCCATTTGGCT

TAAGTTTGGAGTTATCAGATGCTGTGAGCCTGGTGGCTGCTTGTTAGCTT

TGAGAGGATCCATCCAAAAGAGCTTTGTTTTAAACTCTCTACTTAGTTTC

TTACTT

(SEQ ID NO: 133)

pARBI-914:
TTAAACTTTAGAGGTTCAAAATAAGGATATGATATAGAAAAGATTGAATG
1806

CBLB_3_
GTAGGAGAACAGAATAGGATTTATTTATATTATGACAAACGTGACTATCA

Endogenous_12
GTTAATAAATTGGAGATAGTAAGTTAAGATCATTATTTATATTATGGAAA

AATGAAGAAATAGGACATGGTTCTCTAACTTTTTAATTTTTCTGTGAAAT

AAAATATTATGACTTATTTTATTTTTATCTTTGTTTTTAGGTAAGACTGT

GCCAAAATCCCAAACTTCAGTTGAAAAATAGCCCACCATATATACTTGAT

ATTTTGCCTGATACATATCAGCATTTACGACTTATATTGAGTAAATATGA

TGACAACCAGAAACTTGCCCAACTCAGTGAGAATGAGTACTTTAAAATCT

ACATTGATAGCCTTATGAAAAAGTCAAAACGGGCAATAAGACTCTTTAAA

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatGAAGGCAAGGAGAGAATGTATGAAGAACAGTCACAGGACAGGTA

AGAAGAATATTTCAGATGTTTTGGTGTAAAGGTCATTTATGTTGCTTTTT

ACTTAATAGTTAACCTAAACGTCACCATGTAATTGTTTTGGGGTAAATGT

GAGTCGCTTTGTATATagtcatgtggtacttaacgatggggatactttac

aagaaatgcatttttagacaatttcattgttgtgtggacatgatagagtg

tacttacacagagctagatggtattacctaccgcacacctaggctgtatg

atgtagcctattgctcctaggctgcaaatctatacagtatgttactgtac

tgaatactgtgggcagttgtaacacaatggtaagtatgtgtgtatctaaa

tatacctaaacatagaaaaggtatggtaaaaatactgtataaaaggccgg

gcgtgg

(SEQ ID NO: 134)

pARBI-915:
AGATGAGAAAACCTATCCTTCCCAATTTTTTTGTGTGAGAATTAAAATGC
1806

CD2_1_
AGCAAGAAAACACACACTCATAAACACATCTGCTTTGGCAAAGGAGCACA

Endogenous_13_
TCAGAAGGGCTGGCTTGTGCGCGCTCTTGCTCTCTGTGTATGTGTATTAT

14_15
GTTTTATGTTACTGTAAAAGATGTAAAGAGAGGCACGTGGTTAAGCTCTC

GGGGTGTGGACTCCACCAGTCTCACTTCAGTTCCTTTTGCATGAAGAGCT

CAGAATCAAAAGAGGAAACCAACCCCTAAGATGAGCTTTCCATGTAAATT

TGTAGCCAGCTTCCTTCTGATTTTCAATGTTTCTTCCAAAGGTAAGCATA

AGAGTCAAAGAAGTCCCAACCCAGCTTTCCCTGAAAGTGACTCTCAGTAA

CTCTTTTGCTTTTTATAGGTGCAGTCTCCAAAGAGATTACGAATGCCTTG

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatGAAACCTGGGGTGCCTTGGGTCAGGACATCAACTTGGACATTCC

TAGTTTTCAAATGAGTGATGATATTGACGATATAAAATGGGAAAAAACTT

CAGACAAGAAAAAGATTGCACAATTCAGAAAAGAGAAAGAGACTTTCAAG

GAAAAAGATACATATAAGCTATTTAAAAATGGAACTCTGAAAATTAAGCA

TCTGAAGACCGATGATCAGGATATCTACAAGGTATCAATATATGATACAA

AAGGAAAAAATGTGTTGGAAAAAATATTTGATTTGAAGATTCAAGGTAAG

TGTTCATTCCCTTAATTGCTTTATTTCAGTGTGGGTGCTATTTGGCAAGT

TGGAAAATAGCATTTCTAATATTCCCCAGCGCTGACCTCTGCCTCCAGGG

GGGCTATACAGGAAACCAGATGCATGTCTCCTGCCCCAGTGGAGACTGTG

GTCCAA

(SEQ ID NO: 135)

pARBI-916:
AGGATTGTTCTAGTTGATTGGTATGTGTGCACTCCTAGTTGTTAAATATT
1806

CD3E_1_
TTCACTATCACACCTGGATATACTCAACAAATATTTGTTGAGCCAAATAC

Endogenous_16
TCAACACCAGCCAAACACGTAGTATTTACTTTAGCTTAAGCGAATTATTT

AGCCCTGACAGAAGCCCTGGAATGTGGGTCTTTAAGTTCCTATTTTTGAG

ATGGGAAAGCTGAGGCTCACGGAAGGAGGTGACCAGCTCAAGTCTCCTAC

CGTCCATGCCAAATTAGAATTCCAGCCTGCCTCCTGACTTCAAGTCCAAA

GTTCTTCCCACGCACTAAAGCTAGCTCTTCAGTGTCCTTTCTTAGGAGGT

ACTTCCTCCCGCACCACTGACCGCCCCCTCTCTATTTCACCCCCAGCCCA

TCCGGAAAGGCCAGCGGGACCTGTATTCTGGCCTGAATCAGAGACGCATC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatTGACCCTCTGGAGAACACTGCCTCCCGCTGGCCCAGGTCTCCTC

TCCAGTCCCCCTGCGACTCCCTGTTTCCTGGGCTAGTCTTGGACCCCACG

AGAGAGAATCGTTCCTCAGCCTCATGGTGAACTCGCGCCCTCCAGCCTGA

TCCCCCGCTCCCTCCTCCCTGCCTTCTCTGCTGGTACCCAGTCCTAAAAT

ATTGCTGCTTCCTCTTCCTTTGAAGCATCATCAGTAGTCACACCCTCACA

GCTGGCCTGCCCTCTTGCCAGGATATTTATTTGTGCTATTCACTCCCTTC

CCTTTGGATGTAACTTCTCCGTTCAGTTCCCTCCTTTTCTTGCATGTAAG

TTGTCCCCCATCCCAAAGTATTCCATCTACTTTTCTATCGCCGTCCCCTT

TTGCAGCCCTCTCTGGGGATGGACTGGGTAAATGTTGACAGAGGCCCTGC

CCCGTT

(SEQ ID NO: 136)

pARBI-917:
AATAATAAAATAATAACAATACTTAACATTTATTGAGTGCTTATTAAGTC
1806

CD3E_2_
TCAAGCACTGTCTGTACCCAACACTTATCAAGGATTCTTTTTCATGTAAT

Endogenous_17_18
CCTCTCAACAACTATATGGGTTAAGTATCATTTTATTCCCATGAGTAAAG

GGATGAGGAAACAGAGGGTTTGTGAGTTGAAAACACATTTCACGCTTCTC

ACAGCTAGTGAGTAATAAAGCTGGGACTCAAACCCAGGGCTGTTTGACTC

CAGTGCCTCTACCCACGGCCACCACTCTTTGCTTGTCAATGTTGTTCTAA

ACATATTGAAGGGGGGGCTCTGACCGTGGCAAGCGTGTGAGTAGTAAGGG

GAGAATGGCCTTCATGCACTCCCTCCTCACCTCCAGCGCCTTGTGTTTTC

CTTGCTTAGTGATTTCCCCTCTCCCCACCCCACCCCCCACAGTGTGTGAG

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatAACTGCATGGAGATGGATGTGATGTCGGTGGCCACAATTGTCAT

AGTGGACATCTGCATCACTGGGGGCTTGCTGCTGCTGGTTTACTACTGGA

GCAAGAATAGAAAGGCCAAGGCCAAGCCTGTGACACGAGGAGCGGGTGCT

GGCGGCAGGCAAAGGGGTAAGGCTGTGGAGTCCAGTCAGAGGAGATTCCT

GCCAAGGGGGACGACCAGCCTGGGCCAGGGTGGGTGGCAAGTCCACAGCT

AGGTCAGAACAGCTTCTCTAGAGCTTCTATGCACAGCTTCTATTACTGTG

ATGACAAGATCTCAACAGACGGTTTCAAATCTCACATCACTCCCCTCCTT

CCCATCCTAGAAAAGTGCAAAAAAGTTTATGAAAGTGATGGGCTTCCTCA

CATACCTGTCAATGCCTGCAGTCATCCGATTCCGCCCCTAAGCTGTGGGA

AGAGAG

(SEQ ID NO: 137)

pARBI-918:
ACTGTGACCCATGAACCAGTAGGTATTGGCGTCACCTGGGATCCTGACGT
1806

CD3G_1_
TAGTCTCTGTCAATCCTTCTCTTTAGTTCATCTATTCTACCCAAAGTGAT

Endogenous_19_20
CTCATCATCTGGTATGCTGTTAGCAGTTTCTTACCTGTATAGTATCTTCC

AAATAACATGCCCCAAAATCCCAAAGTTTTACCCCTACTAATTACAGCAA

TGTCTCTTTTATTCTTCACCCCCTGACGCAGATATTGGCGTCACCCGAGA

GCATGTTAGTAATGCAGAATCTCCCCTCCCCAGAACTACTAAATAGCACC

TGAAATTTTAACAAGATCCCCATGTGATTCATGTGCACATCAAAGTTTGA

GAAACACTACTCTAATGATCTCCTGGTATGCAGAAGCAGGGAGAATTTCA

GAGGCAAGATCCTTAATAGAACCACGGCTTTTCTCATTTCAGGAAACCAC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatTTGGTTAAGGTGTATGACTATCAAGAAGATGGTTCGGTACTTCT

GACTTGTGATGCAGAAGCCAAAAATATCACATGGTTTAAAGATGGGAAGA

TGATCGGCTTCCTAACTGAAGATaaaaaaaaaTGGAATCTGGGAAGTAAT

GCCAAGGACCCTCGAGGGATGTATCAGTGTAAAGGATCACAGAACAAGTC

AAAACCACTCCAAGTGTATTACAGAAGTATGTAATCCCCTTTGGTCTGTT

TGTTGTGAAATTAATCAGTATTTGCTGTTCTGGTGAGCTTTTTATCTGGG

GTGAAAGTGGAAATAGATCCTCAACAGTAATATTATCGCCTGTTCTCTTA

ATTTCAGCTTGCCTCTTTTAAAATACTGTAAGATACTTCCCTCACCCTAT

TGAAAAACTACAGCCAGTCCTGTAAAATTTTGTTTACCTTTGGGTGGGCT

CCATGG

(SEQ ID NO: 138)

pARBI-919:
TTCGAGACAAGCCTGGCCAACATGATGAAACTCTGTCTCTACTAAAAATA
1806

CD3G_3_
CAAAAAAAATTAACCAGGCGTGGAGGCGCGCGCCTGTAGTCCCAGCTACT

Endogenous_21
CAGGAGGCTGAGGCAGGAGGACCACTTGAACCCAGGAGGTCGAGGTTGCA

GTGAGCTGCGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGAAAGAC

TCCGTCTCAAAAAAAAAAAAGAGAGAGAGAGAAAAAGAAAAAAGACAGAG

CCTCCATCTCCTTGTCCTCTTTCCATCCTCAGGACCATGAAGTACCCACT

CCAAATTCTCACATATAAAAAACATTCAATAAACATGCATCAAATTAATT

AATAGAGGATGGAAAAAATGACTTATGACTGTGCTGTCCTTTCCAGCCCC

TCAAGGATCGAGAAGATGACCAGTACAGCCACCTTCAAGGAAACCAGTTG

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatAGGAGGAATTGAACTCAGGACTCAGAGTAGGTGGGTTCTTCAAT

GCCAATTCTAATAAAGGACCCTTGCATCAACTGCCCTCGCAATTGCTTCT

AAGTCTAGCTCCCTTCCCTAAGCGGCTATAAGCATCAGACTCTGGGGATC

AGGGATTGGGACGTGGTTTGGGGTACTCTTTTCTAAAAATTCTGGGGCCA

TACTGATTGTCTTGGCCTAGGTAAATATGAATTTTATGTATCTGTAAATC

CTGTCAGAGCAGGGCCTCAAGCCATAGAGATGCTGAATATTAATCTTAAC

CTACATTTGAATTTCTCATTATCTACACTATTAACATTTTGGGCTAATTA

ATTATTTGTGATGAGGGGCTAGCCTGTGCATTGTAGGAGTTATGGAAGCA

TCCCTGGCCTCTCTCCACCAGATGCTGGTAGATTGTCCAGTGTGACAATC

AAAAAT

(SEQ ID NO: 139)

pARBI-920:
GACCTCAGGTGATCTGCCCGCCTCAGCTTCCCAAAGTGCTGGGATTACAG
1806

CD5_1_
GCATGAGCCACCACACCTGGCCTAAAATTAATTTTTAAAGATCTCTTAAA

Endogenous_22
AAGCAGACACCAGCCCCAATCTCAGACCCCTTGAGACAGAATTTCCAGGA

CAGGGGCCATCCTGCTGGACAGTGGGTGCCGAGAACACCTTGCCCATTTA

TCTGAGCTCCCTTCTGACTCTGAAATCTGGAGCCCCACCCTCCTGGGTCT

AGCTTCGGGGCTGCCTGGGTCAGGGTCCTCTGGGAAGCCCCTGCAGTGCC

CCAGAAGGGACGAAGCTCACAAGGGGCAAGGCAGGCAGCCCACGGGGCAG

GAGGGAGCTCAACTGGGCGTCCTAGGGAGAGGGCAGTGAGGGGTGCCAGT

GGGGAACCCCTCCCAGCCTGACCCCCACCACACCTTTCTGACCCCCAGAT

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatTTCCAGGCAAGGCTCACCCGTTCCAACTCGAAGTGCCAGGGCCA

GCTGGAGGTCTACCTCAAGGACGGATGGCACATGGTTTGCAGCCAGAGCT

GGGGCCGGAGCTCCAAGCAGTGGGAGGACCCCAGTCAAGCGTCAAAAGTC

TGCCAGCGGCTGAACTGTGGGGTGCCCTTAAGCCTTGGCCCCTTCCTTGT

CACCTACACACCTCAGAGCTCAATCATCTGCTACGGACAACTGGGCTCCT

TCTCCAACTGCAGCCACAGCAGAAATGACATGTGTCACTCTCTGGGCCTG

ACCTGCTTAGGTGGGTAACTAGCCAGCCACACGGGCACCCTGGGCCTGGG

CGCCAGCCCCGAGGAGACTGCCCGAGGCCTGTGATCTAGGGTCTGAGCAG

GCTGGTGGAAGGGGTGGGGGGACCCCAGTTTATAACCACTCCCCAAGACA

CATACC

(SEQ ID NO: 140)

pARBI-921:
GGACAGGGGCCATCCTGCTGGACAGTGGGTGCCGAGAACACCTTGCCCAT
1806

CD5_2_
TTATCTGAGCTCCCTTCTGACTCTGAAATCTGGAGCCCCACCCTCCTGGG

Endogenous_23
TCTAGCTTCGGGGCTGCCTGGGTCAGGGTCCTCTGGGAAGCCCCTGCAGT

GCCCCAGAAGGGACGAAGCTCACAAGGGGCAAGGCAGGCAGCCCACGGGG

CAGGAGGGAGCTCAACTGGGCGTCCTAGGGAGAGGGCAGTGAGGGGTGCC

AGTGGGGAACCCCTCCCAGCCTGACCCCCACCACACCTTTCTGACCCCCA

GATTTCCAGGCAAGGCTCACCCGTTCCAACTCGAAGTGCCAGGGCCAGCT

GGAGGTCTACCTCAAGGACGGATGGCACATGGTTTGCAGCCAGAGCTGGG

GCCGGAGCTCCAAGCAGTGGGAGGACCCCAGTCAAGCGTCAAAAGTCTGC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatCAGCGGCTGAACTGTGGGGTGCCCTTAAGCCTTGGCCCCTTCCT

TGTCACCTACACACCTCAGAGCTCAATCATCTGCTACGGACAACTGGGCT

CCTTCTCCAACTGCAGCCACAGCAGAAATGACATGTGTCACTCTCTGGGC

CTGACCTGCTTAGGTGGGTAACTAGCCAGCCACACGGGCACCCTGGGCCT

GGGCGCCAGCCCCGAGGAGACTGCCCGAGGCCTGTGATCTAGGGTCTGAG

CAGGCTGGTGGAAGGGGTGGGGGGACCCCAGTTTATAACCACTCCCCAAG

ACACATACCCAGGAGGGGGACTGGAAGGGGCCAGCACCCATCTGTAGGAT

GGCAATGGAGGACCTAGTTCTGCCAATCACTGACTTCATCGTCGCCTCTG

AACCTCCATTCTCCCATCTGTGAAGTGGGGTGGTACTTCCCGCCTCGCAG

GAGGCT

(SEQ ID NO: 141)

pARBI-922:
tgctgggattacaggcatgagccaccacacctggcctaaaattaattttt
1806

CD5_3_
aaagaTCTCTTAAAAAGCAGACACCAGCCCCAATCTCAGACCCCTTGAGA

Endogenous_24
CAGAATTTCCAGGACAGGGGCCATCCTGCTGGACAGTGGGTGCCGAGAAC

ACCTTGCCCATTTATCTGAGCTCCCTTCTGACTCTGAAATCTGGAGCCCC

ACCCTCCTGGGTCTAGCTTCGGGGCTGCCTGGGTCAGGGTCCTCTGGGAA

GCCCCTGCAGTGCCCCAGAAGGGACGAAGCTCACAAGGGGCAAGGCAGGC

AGCCCACGGGGCAGGAGGGAGCTCAACTGGGCGTCCTAGGGAGAGGGCAG

TGAGGGGTGCCAGTGGGGAACCCCTCCCAGCCTGACCCCCACCACACCTT

TCTGACCCCCAGATTTCCAGGCAAGGCTCACCCGTTCCAACTCGAAGTGC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatCAGGGCCAGCTGGAGGTCTACCTCAAGGACGGATGGCACATGGT

TTGCAGCCAGAGCTGGGGCCGGAGCTCCAAGCAGTGGGAGGACCCCAGTC

AAGCGTCAAAAGTCTGCCAGCGGCTGAACTGTGGGGTGCCCTTAAGCCTT

GGCCCCTTCCTTGTCACCTACACACCTCAGAGCTCAATCATCTGCTACGG

ACAACTGGGCTCCTTCTCCAACTGCAGCCACAGCAGAAATGACATGTGTC

ACTCTCTGGGCCTGACCTGCTTAGGTGGGTAACTAGCCAGCCACACGGGC

ACCCTGGGCCTGGGCGCCAGCCCCGAGGAGACTGCCCGAGGCCTGTGATC

TAGGGTCTGAGCAGGCTGGTGGAAGGGGTGGGGGGACCCCAGTTTATAAC

CACTCCCCAAGACACATACCCAGGAGGGGGACTGGAAGGGGCCAGCACCC

ATCTGT

(SEQ ID NO: 142)

pARBI-923:
GGGGGCGGCCGCACGGCTAGAGCGGAGACCCCGCGCCCCCTCCGCCCGCG
1806

EDF1_1_
TGGCCCGGCCGGGGTGCGGGGCCCGGGGAGGCACGGGGGCTGCGCGTCGG

Endogenous_25
GGCGCAGCCGCCGCCCGCGTGTGCTCGGAGGCCGCGGGGCCCGGGCTCCG

GGGTCCTCCCGACCTGCAGCCCCAGCGGCTACCGCGCCTCGCCAGGCCAG

GCCAGGCCCCGACGTCGCCTTCCCTACGTCGCCGGCGCCCGGCCACGACG

TCCCTCAGACGAGCCGAACGCCGAATGGCCCCGAGCACGGGAAGTGCCCG

CCCCCCGCGTGCAGCCAGCCAATGGGACGCCGAAAGCGGGGAGGTGCCGA

GGGGACGTAGCGTCGCCGCGCCAGGTCTCTAGCAGCTGCCGCTGAGCCGC

CGGACGGACGCTCGTCTTCGCCCGCCATGGCCGAGAGCGACTGGGACACG

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatGTGACGGTGCTGCGCAAGAAGGGCCCTACGGCCGCCCAGGCCAA

ATCCAAGCAGGTGCTTTGCTGACTGAGGAGCGGCCGGGCCGGGCGGGGCG

GACGCTgggccggggccacggaccgtggggcagggggctcggggaagggc

aggcggggcctgggacagggcgcaggggacggggacaaggctggGGTGCC

GGGGGCAGGACGGGGTTCGAAGGGCGGGGCGAATCGCAGGGGTAGGAGGA

CCGGGCCAGGACaggggtgggaaggtggggggcggacccaggaggggatg

gacggacccaggaggcagggggCGGGCGACTGGAGGAGGAGAGGAGCAGG

GAACCGGACGGGGCAAGGGGCAGGCGATAGGGCCGGGACCAGTGCCAGGG

TGGGGCGGGGAGGGGATAGGGGCAGGGACTGTTGGTGGGGACAGGTGTGA

GGACAG

(SEQ ID NO: 143)

pARBI-924:
ACGGCTAGAGCGGAGACCCCGCGCCCCCTCCGCCCGCGTGGCCCGGCCGG
1806

EDF1_2_
GGTGCGGGGCCCGGGGAGGCACGGGGGCTGCGCGTCGGGGCGCAGCCGCC

Endogenous_26
GCCCGCGTGTGCTCGGAGGCCGCGGGGCCCGGGCTCCGGGGTCCTCCCGA

CCTGCAGCCCCAGCGGCTACCGCGCCTCGCCAGGCCAGGCCAGGCCCCGA

CGTCGCCTTCCCTACGTCGCCGGCGCCCGGCCACGACGTCCCTCAGACGA

GCCGAACGCCGAATGGCCCCGAGCACGGGAAGTGCCCGCCCCCCGCGTGC

AGCCAGCCAATGGGACGCCGAAAGCGGGGAGGTGCCGAGGGGACGTAGCG

TCGCCGCGCCAGGTCTCTAGCAGCTGCCGCTGAGCCGCCGGACGGACGCT

CGTCTTCGCCCGCCATGGCCGAGAGCGACTGGGACACGGTGACGGTGCTG

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatCGCAAGAAGGGCCCTACGGCCGCCCAGGCCAAATCCAAGCAGGT

GCTTTGCTGACTGAGGAGCGGCCGGGCCGGGGGGGGCGGACGCTgggccg

gggccacggaccgtggggcagggggctcggggaagggcaggcggggcctg

ggacagggcgcaggggacggggacaaggctggGGTGCCGGGGGCAGGACG

GGGTTCGAAGGGCGGGGCGAATCGCAGGGGTAGGAGGACCGGGCCAGGAC

aggggtgggaaggtggggggcggacccaggaggggatggacggacccagg

aggcagggggCGGGCGACTGGAGGAGGAGAGGAGCAGGGAACCGGACGGG

GCAAGGGGCAGGCGATAGGGCCGGGACCAGTGCCAGGGTGGGGCGGGGAG

GGGATAGGGGCAGGGACTGTTGGTGGGGACAGGTGTGAGGACAGAGGCAG

GAGGTG

(SEQ ID NO: 144)

pARBI-925:
CCCTGGAGTCGGTGTGAGGCAAAAGCAGAGGAGAGGATTTGGAATTAACC
1806

EDF1_3_
TGAAGAAAAACCATTTCAAAGCGGTAACCAGACCCCAGAGGCTGCCTGAA

Endogenous_27
CTCAAGGGGACATGGGAACCCAGGCTGTCCCAAGTTCACACACCTCAGGT

CGTGGACTTCCAGAGTTTTCTCTCAGTTATGAGGACAGGCAGCTGTACTC

ATGCCAACCAGAGCTGCTCTGGGAAGATGGCTGCCTCCCAGGGCTCCGGC

CAGCACCGGTGCAGGCAGGCACTCAGCTGACAACGTCCCCGGGGGCGCCG

CACACACCACACCCACCAGCACATGGACCCCACAGCACAGCCTCATGTTG

CAAGCGGAAACACAAGTACCTACATTTCTTGGAAGTCTCCACATCTTCTC

CTCGTCTCTGTGCCGCTAAGATAGCCTAGAAAATTAGAAAACATCAGTGG

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatTTTCTAAAGAGAAGATGTGCTTTATACACATCAGCTCCACTAGG

ACTGCTGCAAAACCAGGCGCGAAGCGTCGCCTGAGAACAGCAGCTTCTAG

GGCCCCTGGGGTACGCACCCACACGCAGCTGGGTTTTGTGCGAGAGGCAG

TGAGAGCCGGGCTGACCTGGCTTCCCGAGGCATTCCCTGCAGGGGAACCA

GGGGGGTGGAGCCCACCCTCCCCGTGCTATCTGAACACCGGCCATCCCCC

TCCCCAAACCCACAACCCCAGGAGTGAGAGCCCCGGCGCAGCCTCACCGT

GGCCAGGTCCTTCTGCGTAAGCCCCTTGCTCTGCCGACCTTGCTGGATCA

CCTTGCCCACCTCCAGGGTCACCCTGTCATGGTGCAGCTCCTCTGTCTCC

CGGTCCAGCTTGGCCGTGTTCTTGGTAATAGAATGTTGTTTGTTCTGGCC

AGCAGC

(SEQ ID NO: 145)

pARBI-926:
CTCTTGCTTCAACAGTGTTTGGACGGAACAGATCCGGGGACTCTCTTCCA
1806

FTL_1_
GCCTCCGACCGCCCTCCGATTTCCTCTCCGCTTGCAACCTCCGGGACCAT

Endogenous_2830
CTTCTCGGCCATCTCCTGCTTCTGGGACCTGCCAGCACCGTTTTTGTGGT

TAGCTCCTTCTTGCCAACCAACCATGAGCTCCCAGATTCGTCAGAATTAT

TCCACCGACGTGGAGGCAGCCGTCAACAGCCTGGTCAATTTGTACCTGCA

GGCCTCCTACACCTACCTCTCTCTGGTGAGTCCCCAGGACGCCCCTGGCC

CTAATTTCCTCCAGCTGCGCACCTCCGGCCCTCACTGCACGCGCCAGCCT

TCTTTGTGCGGTCGGGTAAACAGAGGGCGGAGTCCCCTTGGCCTCGCCTC

CCGCTAACCATTGTTGCCTCCATCTCTTCCCGTAGGGCTTCTATTTCGAC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatCGCGATGATGTGGCTCTGGAAGGCGTGAGCCACTTCTTCCGCGA

ATTGGCCGAGGAGAAGCGCGAGGGCTACGAGCGTCTCCTGAAGATGCAAA

ACCAGCGTGGCGGCCGCGCTCTCTTCCAGGACATCAAGGTAACTAGTGTG

TGGGTAATGGACTACATCTCCCAGCAGGCCGTGCGCGCGAGGAGCCTTGA

TTTGAGGGCGTAGGTGTCGCGTGGGCTTCTGGGAGATTGAGTTCGGTCTT

GTGAGCCCTCTTAACCGCTGGAAATAGAGGCGCACCTCGTGCAGTGCCCA

CAACACGCGGCAGTCCACACCGCTGCGTGGTCTTAGGGACGTATAGCTGT

AAGAGCTAGGACAGGGTGCGGAGAGTGATAAATACAAGCTGTCACATGTC

TTTGTGGCCTGGGCCTCTGACCCCCAACGACTCTTGGGAAATGTAGGTTT

AGTTCT

(SEQ ID NO: 146)

pARBI-927:
TGGGGCGGGGGGCTGAGACTCCTATGTGCTCCGGATTGGTCAGGCACGGC
1806

FTL_2_
CTTCGGCCCCGCCTCCTGCCACCGCAGATTGGCCGCTAGCCCTCCCCGAG

Endogenous_29
CGCCCTGCCTCCGAGGGCCGGCGCACCATAAAAGAAGCCGCCCTAGCCAC

GTCCCCTCGCAGTTCGGCGGTCCCGCGGGTCTGTCTCTTGCTTCAACAGT

GTTTGGACGGAACAGATCCGGGGACTCTCTTCCAGCCTCCGACCGCCCTC

CGATTTCCTCTCCGCTTGCAACCTCCGGGACCATCTTCTCGGCCATCTCC

TGCTTCTGGGACCTGCCAGCACCGTTTTTGTGGTTAGCTCCTTCTTGCCA

ACCAACCATGAGCTCCCAGATTCGTCAGAATTATTCCACCGACGTGGAGG

CAGCCGTCAACAGCCTGGTCAATTTGTACCTGCAGGCCTCCTACACCTAC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatCTCTCTCTGGTGAGTCCCCAGGACGCCCCTGGCCCTAATTTCCT

CCAGCTGCGCACCTCCGGCCCTCACTGCACGCGCCAGCCTTCTTTGTGCG

GTCGGGTAAACAGAGGGCGGAGTCCCCTTGGCCTCGCCTCCCGCTAACCA

TTGTTGCCTCCATCTCTTCCCGTAGGGCTTCTATTTCGACCGCGATGATG

TGGCTCTGGAAGGCGTGAGCCACTTCTTCCGCGAATTGGCCGAGGAGAAG

CGCGAGGGCTACGAGCGTCTCCTGAAGATGCAAAACCAGCGTGGCGGCCG

CGCTCTCTTCCAGGACATCAAGGTAACTAGTGTGTGGGTAATGGACTACA

TCTCCCAGCAGGCCGTGCGCGCGAGGAGCCTTGATTTGAGGGCGTAGGTG

TCGCGTGGGCTTCTGGGAGATTGAGTTCGGTCTTGTGAGCCCTCTTAACC

GCTGGA

(SEQ ID NO: 147)

pARBI-928:
CTTTGCATAGTTTATCCTATTAGTAATCTATTCTGTCTTTGGAATATGTT
1806

PTEN_1_
TTGTGATGATGAAATAAATACTATAAATAGTATTATTCCTTTTGCATTGA

Endogenous_31
GAGTCCTGACGAAATGTCCATGTGACAGTTCATTTTGGGTTTAGCTCTAC

CTCTAATATGTGACCTATGCTACCAGTCCGTATAGCGTAAATTCCCAGAA

TATATCCTCCTGAATAAAATGGGGGAAAATAATACCTGGCTTCCTTAATG

ATTATATTTAAGACTTATCAAGAGACTATTTTCTATTTAACAATTAGAAA

GTTAAGCAATACATTATTTTTCTCTGGAATCCAGTGTTTCTTTTAAATAC

CTGTTAAGTTTGTATGCAACATTTCTAAAGTTACCTACTTGTTAATTAAA

AATTCAAGAGTTTTTTTTTCTTATTCTGAGGTTATCTTTTTACCACAGTT

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatGCACAATATCCTTTTGAAGACCATAACCCACCACAGCTAGAACT

TATCAAACCCTTTTGTGAAGATCTTGACCAATGGCTAAGTGAAGATGACA

ATCATGTTGCAGCAATTCACTGTAAAGCTGGAAAGGGACGAACTGGTGTA

ATGATATGTGCATATTTATTACATCGGGGCAAATTTTTAAAGGCACAAGA

GGCCCTAGATTTCTATGGGGAAGTAAGGACCAGAGACAAAAAGGTAAGTT

ATTTTTTGATGTTTTTCCTTTCCTCTTCCTGGATCTGAGAATTTATTGGA

AAACAGATTTTGGGTTTCTTTTTTTCCTTCAGTTTTATTGAGGTGTAATT

GACAAGTAAAAATTATATATAAATACAATGTATAATATGATGTTTTGATG

TATGTGTATATACATTGTGAAATGATTACTACAGTCAAACTACTTAACAT

ATTCAT

(SEQ ID NO: 148)

pARBI-929:
GCTACCAGTCCGTATAGCGTAAATTCCCAGAATATATCCTCCTGAATAAA
1806

PTEN_2_
ATGGGGGAAAATAATACCTGGCTTCCTTAATGATTATATTTAAGACTTAT

Endogenous_32
CAAGAGACTATTTTCTATTTAACAATTAGAAAGTTAAGCAATACATTATT

TTTCTCTGGAATCCAGTGTTTCTTTTAAATACCTGTTAAGTTTGTATGCA

ACATTTCTAAAGTTACCTACTTGTTAATTAAAAATTCAAGAGTTTTTTTT

TCTTATTCTGAGGTTATCTTTTTACCACAGTTGCACAATATCCTTTTGAA

GACCATAACCCACCACAGCTAGAACTTATCAAACCCTTTTGTGAAGATCT

TGACCAATGGCTAAGTGAAGATGACAATCATGTTGCAGCAATTCACTGTA

AAGCTGGAAAGGGACGAACTGGTGTAATGATATGTGCATATTTATTACAT

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatCGGGGCAAATTTTTAAAGGCACAAGAGGCCCTAGATTTCTATGG

GGAAGTAAGGACCAGAGACAAAAAGGTAAGTTATTTTTTGATGTTTTTCC

TTTCCTCTTCCTGGATCTGAGAATTTATTGGAAAACAGATTTTGGGTTTC

TTTTTTTCCTTCAGTTTTATTGAGGTGTAATTGACAAGTAAAAATTATAT

ATAAATACAATGTATAATATGATGTTTTGATGTATGTGTATATACATTGT

GAAATGATTACTACAGTCAAACTACTTAACATATTCATCACCTCACATAA

TTATTATTCTCCCCCCAGGGTGAAAGCATTTAAGATCTACAAGCTACAAT

TTTCAATTATACAATGTTATTATTAACTATAGTCACTATGCTGTCCAGTA

GAGCTTCAGATCTTGTTCATCTTGTGTTCCTCCCTCCCCACCCTCAGTCC

CTGGAA

(SEQ ID NO: 149)

pARBI-930:
ATAAATAGTATTATTCCTTTTGCATTGAGAGTCCTGACGAAATGTCCATG
1806

PTEN_3_
TGACAGTTCATTTTGGGTTTAGCTCTACCTCTAATATGTGACCTATGCTA

Endogenous_33
CCAGTCCGTATAGCGTAAATTCCCAGAATATATCCTCCTGAATAAAATGG

GGGAAAATAATACCTGGCTTCCTTAATGATTATATTTAAGACTTATCAAG

AGACTATTTTCTATTTAACAATTAGAAAGTTAAGCAATACATTATTTTTC

TCTGGAATCCAGTGTTTCTTTTAAATACCTGTTAAGTTTGTATGCAACAT

TTCTAAAGTTACCTACTTGTTAATTAAAAATTCAAGAGTTTTTTTTTCTT

ATTCTGAGGTTATCTTTTTACCACAGTTGCACAATATCCTTTTGAAGACC

ATAACCCACCACAGCTAGAACTTATCAAACCCTTTTGTGAAGATCTTGAC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatCAATGGCTAAGTGAAGATGACAATCATGTTGCAGCAATTCACTG

TAAAGCTGGAAAGGGACGAACTGGTGTAATGATATGTGCATATTTATTAC

ATCGGGGCAAATTTTTAAAGGCACAAGAGGCCCTAGATTTCTATGGGGAA

GTAAGGACCAGAGACAAAAAGGTAAGTTATTTTTTGATGTTTTTCCTTTC

CTCTTCCTGGATCTGAGAATTTATTGGAAAACAGATTTTGGGTTTCTTTT

TTTCCTTCAGTTTTATTGAGGTGTAATTGACAAGTAAAAATTATATATAA

ATACAATGTATAATATGATGTTTTGATGTATGTGTATATACATTGTGAAA

TGATTACTACAGTCAAACTACTTAACATATTCATCACCTCACATAATTAT

TATTCTCCCCCCAGGGTGAAAGCATTTAAGATCTACAAGCTACAATTTTC

AATTAT

(SEQ ID NO: 150)

pARBI-931:
TAGTGACGGTATCAAGAGCAGCATCCCAGGTTGACTTTCTTTGGGGCAGG
1806

PTPN2_1_
ACCTTGCTTGTGTCTTAACCCTTGGTTCCTACccaagtttgtctctctag

Endogenous_34
tcctcaactctgaaagccacttgatatcttacacaattccttttttgcct

gagaaaataaaagtcagttttgatcatttacaaccaaaaatcctaactaa

cacaGACCTGTTTTTGAAATCAGGTAGATTGGAAGTCTTGGTTTACTTCT

TATAAGCCCGTCCGCTGTCTGTCTTGTAACATCCCAGGAGCAGACTTAAC

AAGGCCTTCCTGGAGCCTTGCTCTTTCTGTCTGCTTCCCTCATCTGctct

ctctcctctctctTCACAGGGTCCACTTCCTAACACATGCTGCCATTTCT

GGCTTATGGTTTGGCAGCAGAAGACCAAAGCAGTTGTCATGCTGAACCGC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatATTGTGGAGAAAGAATCGGTGAGTAATATTTAATATTTACAACT

TAGTATACTGTATGTGATCATTAGCATATAAAGATTTTCATTTTGGGGCC

AATATTCATTCCTTAGTTTTGGCCTTTAATTGCTAAAGGCTAGCGGTCAA

AGTGTTTCTGTCCGGAAAAACTCATGTATCCTTTTCCTTTCTTAAGTATT

TTTATAACAATTGCAGACCTTTCATCTCCAAGATAGAAATACAATGGAAT

AAATATGGACTAGCAGTGACATATAGATCTTTGGAATCCCTAGGAATCCT

TATTGACCTATTGTCAATAAGTCCTCTTCCAGCTTTAAGATCTTGTACTG

TTCTACTTCAGATTTCTTACTTTATTCTACATTTCATAATTGCTGGTTTT

TAATGATGATGAAAATTTCCTAATCCACTTCTAATTAGATGTGGCAATGA

CATGCC

(SEQ ID NO: 151)

pARBI-932:
CAGAATTTGAATATGATGTGGCTGACCATAGATACCTCCATTGCATTAAT
1806

PTPN2_2_
TCTGCTTCATAAAGTGTTTGATGCTTGCTTGTAGGTGTTGAATAGAGCCT

Endogenous_35
AATTAGCAGTAAGTAAACAGATCTagagcacagactttggcatctgaagg

accttggttcaatgctgggactgccacttactagctatgggatctttggt

ggatttttaacctttgaaagcctttcatccctcacagatataatggggaa

gaaaatcgtttccattagtattgtgaggattaaatgattaattgatgtaa

acaatgtgctttccatagtacttggcatatcataagtgcttcatGTTATT

TTACGCTGGCTGGGAAGATAAGTTTTGCTGTGGAGAATTTAAGAGGGATA

TTAAAATATATTTTTGTTATTTTAAGGAAATTCGAAATGAGTCCCATGAC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatTATCCTCATAGAGTGGCCAAGTTTCCAGAAAACAGAAATCGAAA

CAGATACAGAGATGTAAGCCCATGTAAGTACTTGTGGGTTTGTGTGCATG

TGTATTTTTTGGTTTGTTTTAGGAGGCAGGATGTAGTGAAAAGGAGGGCT

TGGGGTCAGTGTTGATAAATACAGTAATTTTTTTCCTATTTACGTAAGAC

ACGTTCTTTAAGAATTTAAAGGTGTAGAATAGTGGAAGGAAAAATAATTA

CCCATAATTATTTCATCCTTCAAACATAGGCACCATTATTTTGGTGTATT

TCCCACAACCTGTTTTTCTTATGCACAGTTTTCCTTTCTTTAAAATAATT

GTAATTATAGATGTCTATATAATATCCATATGTATTTCCTTTTCATATCA

TTCCATCCCCTTTGTAAGTTTTGCTTAAAATAGTTATTGGTGTAGTTTGG

TTTTTT

(SEQ ID NO: 152)

pARBI-933:
ACCAGTTATCGTTTTGTAGGTAGACCAATCAATTCTTAGGTACCAAGAAT
1806

PTPN_3_
CTGAATGATCCTTTTACTTTTAGGAAGGTAAGTACTTTATTCATTTAACT

Endogenous_36
ATGTTTACTCCTGGTCGATTTTTCAAGTCACAATGGCTAATGTGCTACAA

ACAGAAGTGCTTCCTTTCCAGCACTATAGTAATAAACAAGATTGCATTTT

ATACTCCTTACAAAAAAAGTAGAGAATAGTTTAGGATTTGTCTCAACTCT

ATTATGATGCTAATTCATTTTTCTTATTTCTTCTGTCTTTTTATAAATAC

CTAGAATATTAATATGAAGATAAAAACAGTAATTTTGAAATGACAGTTGT

GGTTTATCATTCTCTATTTTCAGATGATCACAGTCGTGTTAAACTGCAAA

ATGCTGAGAATGATTATATTAATGCCAGTTTAGTTGACATAGAAGAGGCA

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatCAAAGGAGTTACATCTTAACACAGGCAAGTAATACGATACCACG

CAAATGTCTGAAAATGATGTGTTTGTGCTTGTTCTGCTTTAAATCATAGG

TAAAAGTATATCTTGACTTCTTTTGGAAATGAAATGGTATTTCAGTTTTT

TTCTGACGATGTAATGAATTATGGACATTATAAGGTTTTGAAGCTTTGAG

TATTTAAGATAAAAGGCAAGTTATTTTTGATATTACACGTTCTGTGAAGG

AAAATTCTTAGGAAATGGCTTAGGCCAGTTCTTTGGCAGATTGTGTTCCT

TACATTATATCTGACACAGAGTGCTGCTTATGCTTCTTAGTGTCTTCTTT

TCTCTTCCCATACCCTGTGGCAAAACCAGAGGCCCTGGACAGCTCTTCTG

TAGCTCCCCCTGCCTCGCATATATCTTCAGAGAGTACACCAAGCCCTGGA

TGGTGT

(SEQ ID NO: 153)

pARBI-934:
CCTGCTCAAGGGCCGAGGTGTCCACGGTAGCTTCCTGGCTCGGCCCAGTC
1806

PTPN6_1_
GCAAGAACCAGGGTGACTTCTCGCTCTCCGTCAGGTAGGTGGGCCCCCCG

Endogenous_37
CAACCCCGGGCATTTTGGCCACTCTCTTGTGCCATCCAGGCCCTGAACCA

CTCATTCCTGGTTCCCCGTGGCAGTGCTGACTCCCCGTCTGTTCCCTTGC

CCCCAACCCCCACACTCCCCATCCCTGTCTGTGCCCACCCATGCCCATGT

GTGCCCCCACCCAGGACCTCAGCCGATCCCTGCCCTCCTGCCTCTACTCC

TGCACCGACTGGCCTCACCGCCTGGTGCCCTGCAGGGTGGGGGATCAGGT

GACCCATATTCGGATCCAGAACTCAGGGGATTTCTATGACCTGTATGGAG

GGGAGAAGTTTGCGACTCTGACAGAGCTGGTGGAGTACTACACTCAGCAG

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatCAGGGTGTCCTGCAGGACCGCGACGGCACCATCATCCACCTCAA

GTACCCGCTGAACTGCTCCGATCCCACTAGTGAGAGGTGAGGGCTCCGCA

CCCCCGCCATTCCCAAGCAGGGATGAGCCGGCTCCCACCCTGAACAGCCA

GGGAGGCAGGGAGACTGGCAGCCGGCGCTGCCTACCCTCCATCCCCTCCC

CTCCCTGCACCAGCTGGGGCTCTCAATGTCCCTCCTCCCTGCTGTCCTGG

GACCTGGTGTCTCAGAGCCTAACCTACCACCCTTTCCACCTAACCCCGAG

GAAGCCACAGAAAGCTGCCTCGCCCTACTCCGGGAGCCCTGGCCGCTGCA

ACCCAGGTCCCACTGGAGACAGGGAGGCCACTGCTGGTGGCCAGCATGTC

GTGCAGGCCAGCTCTGTTGTTAGAAAGCTCTTCTTCCTCTGGAATCGAGC

CTGCCT

(SEQ ID NO: 154)

pARBI-935:
CTGGGTTCGAAGCCCGGTTAGAACTCTGGAGGCTAGGATGGCTTGAACCT
1806

PTPN6_2_
GGGAGGTCGAGGCTGCAGAGAGCTGTAACCGCGCCACTGCACTCCAGCCT

Endogenous_38
GGGCAACAGAGCTCTGGAAGCTTGCCCTAGAGTCAGTCAAGGGCCCTAGG

CCAGTGAGTAACAGCTCAGCGTCAGTTTCCTCATCTATAAAATGGGGGTA

ATATCATACCTAGCTCTCAGCATGTTTGTGAGAGACCTAAATGAGGTGGT

GGATTTGGAAGCATGTAGCGCAGTGCCTGGCACACAGTAGGTGCTTGATT

TCCGGCCCCTCTCTGTGAATGTCTCTGCTCAGCGCCTTCCCCTGTGGCCT

GGGTCTTACCTTCCCTGACGCTGCCTTCTCTAGGTGGTACCATGGCCACA

TGTCTGGCGGGCAGGCAGAGACGCTGCTGCAGGCCAAGGGCGAGCCCTGG

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatACGTTTCTTGTGCGTGAGAGCCTCAGCCAGCCTGGAGACTTCGT

GCTTTCTGTGCTCAGTGACCAGCCCAAGGCTGGCCCAGGCTCCCCGCTCA

GGGTCACCCACATCAAGGTCATGTGCGAGGTAAGGCAGCCAGGCGGCGGG

GGAGCCTCTGCTGAGGCTCCTGTCTGTGACCACAGTGTGGGTGGCAGGGA

GGGTCTGCCTGGGCTTGAATTCAAGGCTGGGGACCCAGGGAGGGAGACTC

AAGTCCTGTGAATGGCCTAATTTGGCTCCCCCCAGGGTGGACGCTACACA

GTGGGTGGTTTGGAGACCTTCGACAGCCTCACGGACCTGGTGGAGCATTT

CAAGAAGACGGGGATTGAGGAGGCCTCAGGCGCCTTTGTCTACCTGCGGC

AGGTCAGGGGTGGGCCCAGCTGCCTCCCCACTTCCCCTGAGCTGTCCCCC

AGATGT

(SEQ ID NO: 155)

pARBI-936:
TGTCACATATGTGCAATGCCATGCTCCTGAGCCTTTGATTGCAGACGTGT
1806

PTPN6_3_
GGGAAGTGGGCCCCGTCCCCACCCCCAGTGCCACCCTGCTCTGCTTCTCT

Endogenous_39
TCCCTTGCTGTGCTCTAAAACGAGAAGTACAAGTGAGTTCCCCCAAGGGG

TCGGCCGCGCCTCTTCCTGTCCCCGCCCTGCCGGCTGCCCCAGGCCAGTG

GAGTGGCAGCCCCAGAACTGGGACCACCGGGGGTGGTGAGGCGGCCCGGC

ACTGGGAGCTGCATCTGAGGCTTAGTCCCTGAGCTCTCTGCCTGCCCAGA

CTAGCTGCACCTCCTCATTCCCTGCGCCCCCTTCCTCTCCGGAAGCCCCC

AGGATGGTGAGGTAAGGGCCTGCCACCCACGGTAGACAGGAGGCAAGGGT

GCCTGGTGCCCACGGGACCCCTCCTCACTGCCCTGCCTGGGCCGCCCAGG

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatTGGTTTCACCGAGACCTCAGTGGGCTGGATGCAGAGACCCTGCT

CAAGGGCCGAGGTGTCCACGGTAGCTTCCTGGCTCGGCCCAGTCGCAAGA

ACCAGGGTGACTTCTCGCTCTCCGTCAGGTAGGTGGGCCCCCCGCAACCC

CGGGCATTTTGGCCACTCTCTTGTGCCATCCAGGCCCTGAACCACTCATT

CCTGGTTCCCCGTGGCAGTGCTGACTCCCCGTCTGTTCCCTTGCCCCCAA

CCCCCACACTCCCCATCCCTGTCTGTGCCCACCCATGCCCATGTGTGCCC

CCACCCAGGACCTCAGCCGATCCCTGCCCTCCTGCCTCTACTCCTGCACC

GACTGGCCTCACCGCCTGGTGCCCTGCAGGGTGGGGGATCAGGTGACCCA

TATTCGGATCCAGAACTCAGGGGATTTCTATGACCTGTATGGAGGGGAGA

AGTTTG

(SEQ ID NO: 156)

pARBI-937:
TCTTTAGCTAATGTTCTGTAGCTTGTTTTAGATCTGTGTCTACATATTAT
1806

PTPRC_1_
ATGTATCTCTGTATGCATCAATATTTGTATATATGCATGCATATATGTGT

Endogenous_40
ATGTATATTTATGAATACATATACACACCATATACATACACTTATGTATG

GTGTGTGCATATGTATGTGTAGATATATGTACATACACACTATAGTGGAC

TGGGGAGTTAGTATACTGGGAGGAGCATACATTTAGGGTATGATTCACAT

ATTTATTTTGTCCTTCTCCCATTTTCCATTAATTAACAGGATTGACTACA

GCAAAGATGCCCAGTGTTCCACTTTCAAGTGACCCCTTACCTACTCACAC

CACTGCATTCTCACCCGCAAGCACCTTTGAAAGAGAAAATGACTTCTCAG

AGACCACAACTTCTCTTAGTCCAGACAATACTTCCACCCAAGTATCCCCG

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatGACTCTTTGGATAATGCTAGTGCTTTTAATACCACAGGTTGGCA

CACAAAAGTTGTTAACTTAAATATCAGGGAATGTCATTTAGAAAATTCTA

CAGTTATCAGTACAACTTGTCTTTAAATTATTTGCACAGTTTCTAAGTAT

GTGATTTTATTCAAGTGCAGAAATTGCAGGAAATTAGTATCTGTGAAATA

TAGATCGACTGAAGTAATTAATGCATGTTGTTAGGGAGTGGAGAGAGAAA

AGAAGGGAAGCAAGATCTCCAAGGACAATCAGGAGGGGAAATTTGTTCTA

GTATCCTCTGATCTATACACACTCGCCATGATTCTCCCGCTTGGCTTCCC

GCCACCTGGACAGATGAGAATTTCCCTAGTTCAGAGATTATCAGTTCTAC

TCTCCTTGGAAGGTGTCTTAAATGGGAGTCTTCCCATTTCTTTGTTTCAC

TCTAGA

(SEQ ID NO: 157)

pARBI-938:
AGGGAATTTTTATATGTTGGTCATATTATATCCCTAGCATGTGGCATAAT
1806

PTPRC_2_
GTCTAGCACAAAATAGGTGCTCAATTAATCATCATTATCTAAATAAATAA

Endogenous_41
TGCATTTGGGAAAAAAAAGTTTCAAAAGTTTTTCAAAAGTCTTTTGCAGG

CTTGAAATTAATCCCAATAGTGATCCTTTAGTCTGTTATGTTTCTGATTT

AGCCTGGGGATTCAAAAAATAAATAACATAATTTTGATATATTTGGGCTT

TGTAAACATGGTACTAAGAGAGGAAATATAGTTTCATTAGGGTAAAAGCT

ACTGAAAATTGCCACTTGGTGAATGTTCTATCATAGACTTGAGGTACATA

TAAAAATCTAATATATGTTTACATTAATATGAATGAAATTTGAAATTTTC

TAAGAGATTTTTGTTTCTTCTTTGCAGGGCAAAGCCCAACACCTTCCCCC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatACTGGTAAGAATTAATATTTATATTTTTACTAATTTTATTTTCT

TGTTGCAAAGTTTATATATTTAACTACAATTTTCTATTATTAACACTGAA

ATTATTTTTAAGGATAAATTTTATAATCATGAGTGATTCTTGACATTCAC

TTGTTCTTAAACTTTCTGCTTATACGTTATAGAGTTTAATAACTACCTAA

ACATGTTATTAAATTTGTATATATATTTTGTGTATAAATAGTAACTTTTC

CCAAACTTGACAGTAAATCACACAACAGGTTTCTACTCTCTTTTAATATT

TTAAGACTATAAAAAAATGCATTTAAATTAGATAACAAAATTTTATAGTC

TGAAAGCAGGTTAACAGCTGTCTATGTATGTTATAGATATGTAGATAACA

GATTTGCATATGTCTATATTTCTTTAAGAGTATGTTGCTTTTTTCAATGG

TATGCA

(SEQ ID NO: 158)

pARBI-939:
CCTTTAGCACCATAAAGAAACTAAATTATTTAGATGTTTTTATGAGAACA
1806

PTPRC_3_
TATCAAAAAGTACTTTTCTGTCATCCAATACTTCCACAAATAAATCATTA

Endogenous_42
GTTCTTGCTAATCTTCATCTGGCATAAAAATAATGACATCAACTTTCTTC

ATGTAATTTCCCACTTAATTCCTTTACTAGGAGCAATATCAATTCCTATA

TGACGTCATTGCCAGCACCTACCCTGCTCAGAATGGACAAGTAAAGAAAA

ACAACCATCAAGAAGATAAAATTGAATTTGATAATGAAGTGGACAAAGTA

AAGCAGGATGCTAATTGTGTTAATCCACTTGGTGCCCCAGAAAAGCTCCC

TGAAGCAAAGGAACAGGCTGAAGGTTCTGAACCCACGAGTGGCACTGAGG

GGCCAGAACATTCTGTCAATGGTCCTGCAAGTCCAGCTTTAAATCAAGGT

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatTCATAGGAAAAGACATAAATGAGGAAACTCCAAACCTCCTGTTA

GCTGTTATTTCTATTTTTGTAGAAGTAGGAAGTGAAAATAGGTATACAGT

GGATTAATTAAATGCAGCGAACCAATATTTGTAGAAGGGTTATATTTTAC

TACTGTGGAAAAATATTTAAGATAGTTTTGCCAGAACAGTTTGTACAGAC

GTATGCTTATTTTAAAATTTTATCTCTTATTCAGTAAAAAACAACTTCTT

TGTAATCGTTATGTGTGTATATGTATGTGTGTATGGGTGTGTGTTTGTGT

GAGAGACAGAGAAAGAGAGAGAATTCTTTCAAGTGAATCTAAAAGCTTTT

GCTTTTCCTTTGTTTTTATGAAGAAAAAATACATTTTATATTAGAAGTGT

TAACTTAGCTTGAAGGATCTGTTTTTAAAAATCATAAACTGTGTGCAGAC

TCAATA

(SEQ ID NO: 159)

pARBI-940:
aaggaaaaaggcactgagtgctggggggtgctggggtgggctgcagtgat
1806

PTPRCAP_1_
agacatcagggtagaggttaaggtcaggttcagcctcactggggtgaagt

Endogenous_43
ttgagcacggtgagcaggccatgcagcccgggggaggggaggatgggagg

aggtggagctttccgggcagagggaacagccagtgcgaaggccccaggca

ggtggcttaatgcagctgttgggggaggtgagtggtagggaggaggctgg

agggatgggggctgatctcacagggccagagcctggttgaccaaataagg

ccttggccttttctGCTTGGCTGTCCCAAGAGGATCCCAAAGAGAAAAAA

ACGAAAGTGGTCTTGGTCACCCAGCCTGCCCCACACCAGGCCCCACCCCA

GGTGCTGAGCCCTCTGAGCCCCTGCCTGTCTCCCACAGGCTCTGCCCTGC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatACCTTAGGGCTCGGGATGCTGCTGGCCCTGCCAGGGGCCTTGGG

CTCGGGTGGCAGCGCGGAGGACAGCGTGGGCTCCAGCTCTGTCACCGTTG

TCctgctgctgctgctgctcctactgctgGCCACTGGCCTAGCACTGGCC

TGGCGCCGCCTCAGCCGTGACTCAGGGGGCTACTACCACCCGGCCCGCCT

AGGTGCCGCGCTGTGGGGCCGCACGCGGCGCCTGCTCTGGGCCAGCCCCC

CAGGTCGCTGGCTGCAGGCCCGAGCTGAGCTGGGGTCCACAGACAATGAC

CTTGAGCGACAGGAGGATGAGCAGGACACAGACTATGACCACGTCGCGGA

TGGTGGCCTGCAGGCTGACCCTGGGGAAGGCGAGCAGCAATGTGGAGAGG

CGTCCAGCCCAGAGCAGGTCCCCGTGCGGGCTGAGGAAGCCAGAGACAGT

GACACG

(SEQ ID NO: 160)

pARBI-941:
aaggtcaggttcagcctcactggggtgaagtttgagcacggtgagcaggc
1806

PTPRCAP_2_
catgcagcccgggggaggggaggatgggaggaggtggagctttccgggca

Endogenous_44
gagggaacagccagtgcgaaggccccaggcaggtggcttaatgcagctgt

tgggggaggtgagtggtagggaggaggctggagggatgggggctgatctc

acagggccagagcctggttgaccaaataaggccttggccttttctGCTTG

GCTGTCCCAAGAGGATCCCAAAGAGAAAAAAACGAAAGTGGTCTTGGTCA

CCCAGCCTGCCCCACACCAGGCCCCACCCCAGGTGCTGAGCCCTCTGAGC

CCCTGCCTGTCTCCCACAGGCTCTGCCCTGCACCTTAGGGCTCGGGATGC

TGCTGGCCCTGCCAGGGGCCTTGGGCTCGGGTGGCAGCGCGGAGGACAGC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatGTGGGCTCCAGCTCTGTCACCGTTGTCctgctgctgctgctgct

cctactgctgGCCACTGGCCTAGCACTGGCCTGGCGCCGCCTCAGCCGTG

ACTCAGGGGGCTACTACCACCCGGCCCGCCTAGGTGCCGCGCTGTGGGGC

CGCACGCGGCGCCTGCTCTGGGCCAGCCCCCCAGGTCGCTGGCTGCAGGC

CCGAGCTGAGCTGGGGTCCACAGACAATGACCTTGAGCGACAGGAGGATG

AGCAGGACACAGACTATGACCACGTCGCGGATGGTGGCCTGCAGGCTGAC

CCTGGGGAAGGCGAGCAGCAATGTGGAGAGGCGTCCAGCCCAGAGCAGGT

CCCCGTGCGGGCTGAGGAAGCCAGAGACAGTGACACGGAGGGCGACCTGG

TCCTCGGCTCCCCAGGACCAGCGAGCGCAGGGGGCAGTGCTGAGGCCCTG

CTGAGT

(SEQ ID NO: 161)

pARBI-942:
cagtgcgaaggccccaggcaggtggcttaatgcagctgttgggggaggtg
1806

PTPRCAP_3_
agtggtagggaggaggctggagggatgggggctgatctcacagggccaga

Endogenous 45
gcctggttgaccaaataaggccttggccttttctGCTTGGCTGTCCCAAG

AGGATCCCAAAGAGAAAAAAACGAAAGTGGTCTTGGTCACCCAGCCTGCC

CCACACCAGGCCCCACCCCAGGTGCTGAGCCCTCTGAGCCCCTGCCTGTC

TCCCACAGGCTCTGCCCTGCACCTTAGGGCTCGGGATGCTGCTGGCCCTG

CCAGGGGCCTTGGGCTCGGGTGGCAGCGCGGAGGACAGCGTGGGCTCCAG

CTCTGTCACCGTTGTCctgctgctgctgctgctcctactgctgGCCACTG

GCCTAGCACTGGCCTGGCGCCGCCTCAGCCGTGACTCAGGGGGCTACTAC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatCACCCGGCCCGCCTAGGTGCCGCGCTGTGGGGCCGCACGCGGCG

CCTGCTCTGGGCCAGCCCCCCAGGTCGCTGGCTGCAGGCCCGAGCTGAGC

TGGGGTCCACAGACAATGACCTTGAGCGACAGGAGGATGAGCAGGACACA

GACTATGACCACGTCGCGGATGGTGGCCTGCAGGCTGACCCTGGGGAAGG

CGAGCAGCAATGTGGAGAGGCGTCCAGCCCAGAGCAGGTCCCCGTGCGGG

CTGAGGAAGCCAGAGACAGTGACACGGAGGGCGACCTGGTCCTCGGCTCC

CCAGGACCAGCGAGCGCAGGGGGCAGTGCTGAGGCCCTGCTGAGTGACCT

GCACGCCTTTGCTGGCAGCGCAGCCTGGGATGACAGCGCCAGGGCAGCTG

GGGGCCAGGGCCTCCATGTCACCGCACTGTAGAGGCCGGTCTTGGTGTCC

CATCCC

(SEQ ID NO: 162)

pARBI-943:
ATAGAGTAGGGCGGGGGATGCCATGGAGAGGCTCCATGGGGGAGGGCCGG
1806

RPS23_1_
GGAAGCGCCGCTCCAGGAGGCACGTGGTCCGGCGCGGAAGGGGCCCATGA

Endogenous_46
GGCGTGGAGGCCGCCGAGGTCGGGGTACCGAGGGACGCAGGGAGGCCAGC

GCTTCCTCCCGGGCATTCGAGCGGGGCCTCGTCCTTCGGGAGAACACATT

CTCCGGAGCCCTCTTCGAACGTTTATTAGTCGGTTCAGGGCAACTTGAAG

GCCAAATGTTTGGCCCACAGGCCAATAAATAGTACGAGAGCCAATCGGCT

TAAGGGTTTATTCCAGGTGAGGCGAGTGTCTTAGAAGATGGGAAACACGT

AGATGGCGTGTTTTTACGGAAGAACTAAAATATTTAATTTTTAGGCAAGT

GTCGTGGACTTCGTACTGCTAGGAAGCTCCGTAGTCACCGACGAGACCAG

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatAAGTGGCATGATAAACAGTATAAGAAAGCTCATTTGGGCACAGC

CCTAAAGGCCAACCCTTTTGGAGGTGCTTCTCATGCAAAAGGAATCGTGC

TGGAAAAAGTGTAAGTCCATTGCTCCCGTCAAGTTTTAGTTTATTATAGG

AATTCGAGACATGAACTTACGAATTCTTGTTTTGAAAGTAATTGCAGGTT

TTTGTGTAGTAGTATTCATTTGGGCATTGTGGGGTAAAATTGCAAAGCGT

TTGTTCTATTTAAAAGTTGGTAAAATTAGTTTTTGGGAATTAGGTAGTTA

AGGTTTTAATTTAACGTTGGCCTGGAAGGAATTGGAGAAGATACTAGCAA

TGATGAAGTAAAGGACACAAACACCTTTACTGTGGGAGTTGTTATAAGTA

AATGGCACGTGTCAGCTATTGAACTTTATCGACTTGATAAAACTAAGGTG

AAGAGA

(SEQ ID NO: 163)

pARBI-944:
CAAGCGGGACTTGGGGTCTTGGGGACGGGCGGGCGGATGCGAATAGAGTA
1806

RPS23_2_
GGGCGGGGGATGCCATGGAGAGGCTCCATGGGGGAGGGCCGGGGAAGCGC

Endogenous_47_48
CGCTCCAGGAGGCACGTGGTCCGGCGCGGAAGGGGCCCATGAGGCGTGGA

GGCCGCCGAGGTCGGGGTACCGAGGGACGCAGGGAGGCCAGCGCTTCCTC

CCGGGCATTCGAGCGGGGCCTCGTCCTTCGGGAGAACACATTCTCCGGAG

CCCTCTTCGAACGTTTATTAGTCGGTTCAGGGCAACTTGAAGGCCAAATG

TTTGGCCCACAGGCCAATAAATAGTACGAGAGCCAATCGGCTTAAGGGTT

TATTCCAGGTGAGGCGAGTGTCTTAGAAGATGGGAAACACGTAGATGGCG

TGTTTTTACGGAAGAACTAAAATATTTAATTTTTAGGCAAGTGCCGCGGA

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatCTTCGTACTGCTAGGAAGCTCCGTAGTCACCGACGAGACCAGAA

GTGGCATGATAAACAGTATAAGAAAGCTCATTTGGGCACAGCCCTAAAGG

CCAACCCTTTTGGAGGTGCTTCTCATGCAAAAGGAATCGTGCTGGAAAAA

GTGTAAGTCCATTGCTCCCGTCAAGTTTTAGTTTATTATAGGAATTCGAG

ACATGAACTTACGAATTCTTGTTTTGAAAGTAATTGCAGGTTTTTGTGTA

GTAGTATTCATTTGGGCATTGTGGGGTAAAATTGCAAAGCGTTTGTTCTA

TTTAAAAGTTGGTAAAATTAGTTTTTGGGAATTAGGTAGTTAAGGTTTTA

ATTTAACGTTGGCCTGGAAGGAATTGGAGAAGATACTAGCAATGATGAAG

TAAAGGACACAAACACCTTTACTGTGGGAGTTGTTATAAGTAAATGGCAC

GTGTCA

(SEQ ID NO: 164)

pARBI-945:
TTGTATATCCTTTTTAAAGTTATTCTTTTTAGTTAATTGCTCTATGTGTA

1806RTRAF_1_
TTGAGACTAGGAATCAGAAAGCTTAGATTCTAGTCCCAGGTGTAAGTTGT

Endogenous_49
GTAACCCTTGGCAAGTGTCAATCTCTAGGCCTCAGCTTTCTCATCTATAA

AATGAGGAAGTTGTCGTATTCTATTTTTTTTCTTAAGATGATACACTTAA

ATGTTCCCTTCTGTTGGGTTATATAATTGCATCAAAAGTGTAGTAATGTT

ATTAAAAAATTGTTAGAGATCCAAACTAAGGTCTCTTTCAACTCTCCCAT

TCTTTTTTCTGTGACTTTATGGTAATAATGAAACTGGTGGTTTTCTTTTC

TTCCCCCTCACAGTATCTCAGAGATGTTAACTGTCCTTTCAAGATTCAAG

ATCGACAAGAAGCTATTGACTGGCTTCTTGGTTTAGCTGTTAGACTTGAA

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatTATGGAGATAATGGTACGTTTTGTGGGGAATGTGTATTTTAAAG

AGAGAGGAAAGATGGGAAAGGGAGTGTGAAAATGTAGGGAACTTTGCAGT

TTGTTTTGTCTAGTACTATTTTACCTTTGGTTTATTCTTATCACAAGTTA

AAAGCACTTTTATTGTCTTTCATTGGTGTTTATATATTTCTGTTAGAATT

TGGAAATGGTGCCCTCTGGAGAAGGCTAATTGACTGTCTTCTCACAGAGT

AACACTACTTTGATAATATGGTCTGCACCTTAGCCTTTCAAATTAAATTG

TTTTTAGTGTCCCAGAATTGATGGGACTTTGAAGTGTTGTTGCAGTAGGT

AATTTCTCAAAAGACTGAAACATGTCTAATGCCAATATACATTAATACTC

TATAGGCCAGAATATATTACTTATGTTTACTGTCTTAGCACAGATACTTC

TATGGT

(SEQ ID NO: 165)

pARBI-946:
GCACCTGTTATGTAGGAGGAGTAATAAAATGAATGAATGCACTCAAAACA
1806

RTRAF_2_
CTAAACAGTAATTCTGTAATCCAACGGGAGGTACAGCGAATACCAAAAGC

Endogenous_50
CTACATATACTATTCTCTGCATGCTATAGCAAGAAAGAAAGGAAAGTGGC

TTCCCGGTGGTTTTCTGCCTATTGTACAACCAGGAAGCTGACAATAAAGT

TTATTTGAGCGTCGACGTGCGCCGACGTGGCCCCGCCTCCCCAGCCGGAG

CCGCGATTGGTGGGCATTTGCCGGCGGCCACCGCTTTTAAGCCACGATTG

GCGAAGGCCGCCGTCATTTCGGAGCGACTCAGCGCCTGCCCGCCCTCTCG

CCGCGTCGCCGGTGCCTGCGCCTCCCGCTCCACCTCGCTTCTTCTCTCCC

GGCCGAGGCCCGGGGGACCAGAGCGAGAAGCGGGGACCATGTTCCGACGC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatAAGTTGACGGCTCTCGACTACCACAACCCCGCCGGCTTCAACTG

CAAAGGTGAGGCGGCGGCCTCAGCCCGGCCGCGTGTCCCTGACCTGGGCG

GAGGTCCCAGCCTCAGTGCCCGCACCCCACCTCCCCGTCGGGACCCTCGG

CGGCCTGGTTTCCGCCGGCAGCCTCCGGGCCCCTCTCCTCTGGGTCGCCA

CGTACCTCGGCTCTTCGCCGCCCCTTCCCGCCTTTAAAGCCCTCTCACCT

ACTCCTGTCTCGGCATGTTACTTTCTGCACTTGCTTAACTCCAAGCATCA

CGTAACTACCTTCTCTGTACATAAAAGGGAGAGCATTCGTCTTTCTCACT

CACTATTCAACTCCATGGTTCCCTGGGTAATTAGGCGATACCTTGAGCAC

CTGCTAATTATGGGCCAGCGCGGTGCTGGATTCTGAGGAAGGTGCTGAGT

AACTTG

(SEQ ID NO: 166)

pARBI-947:
CACTAAACAGTAATTCTGTAATCCAACGGGAGGTACAGCGAATACCAAAA
1806

RTRAF_3_
GCCTACATATACTATTCTCTGCATGCTATAGCAAGAAAGAAAGGAAAGTG

Endogenous_51
GCTTCCCGGTGGTTTTCTGCCTATTGTACAACCAGGAAGCTGACAATAAA

GTTTATTTGAGCGTCGACGTGCGCCGACGTGGCCCCGCCTCCCCAGCCGG

AGCCGCGATTGGTGGGCATTTGCCGGCGGCCACCGCTTTTAAGCCACGAT

TGGCGAAGGCCGCCGTCATTTCGGAGCGACTCAGCGCCTGCCCGCCCTCT

CGCCGCGTCGCCGGTGCCTGCGCCTCCCGCTCCACCTCGCTTCTTCTCTC

CCGGCCGAGGCCCGGGGGACCAGAGCGAGAAGCGGGGACCATGTTCCGAC

GCAAGTTGACGGCTCTCGACTACCACAACCCCGCCGGCTTCAACTGCAAA

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatGGTGAGGCGGCGGCCTCAGCCCGGCCGCGTGTCCCTGACCTGGG

CGGAGGTCCCAGCCTCAGTGCCCGCACCCCACCTCCCCGTCGGGACCCTC

GGCGGCCTGGTTTCCGCCGGCAGCCTCCGGGCCCCTCTCCTCTGGGTCGC

CACGTACCTCGGCTCTTCGCCGCCCCTTCCCGCCTTTAAAGCCCTCTCAC

CTACTCCTGTCTCGGCATGTTACTTTCTGCACTTGCTTAACTCCAAGCAT

CACGTAACTACCTTCTCTGTACATAAAAGGGAGAGCATTCGTCTTTCTCA

CTCACTATTCAACTCCATGGTTCCCTGGGTAATTAGGCGATACCTTGAGC

ACCTGCTAATTATGGGCCAGCGCGGTGCTGGATTCTGAGGAAGGTGCTGA

GTAACTTGAAGACTAGTTCACTGCCTGCCAGGAGCTAAAGGGACGAGGGG

TGGAAG

(SEQ ID NO: 167)

pARBI-948:
CCGGGTTAGGCATAGGCCCTCCCGGATCTTCCGCGGTGTAAGGAGAAGGC
1806

SERF2_1_
CAGCGCCCCTGTGATAGGCCCAGAGCCCCCACTCCACAAGCCAGCCCATC

Endogenous_52
CCCCACGGAGACCCAAACCGTCCACACACACCTTGCCAGCTGTTTGGGCC

CCACGCCGCCCCAAAACACGCCTCCAGCTGGCCCCTTGGGACCTCCCTTC

TCTAGTCCGTATTTTGACCTGGCCCGTGGCAGATTCGCCACTCCCCCCTA

CCCCAAGCAGCCTGGGCCTCGATGGGCCGTTGTCGGGGCCCGGAGATTGA

AGTGGTGTTGGATCCTGCTGCTGGCCGCGCTGGGGTAGAAGGGTCGCCGG

TGTGTGGGCAGAGCGGCCCCCGCGTCTCACCTTTAATTTTCTTTCCTTAG

GCGGTAACCAGCGTGAGCTCGCCCGCCAGAAGAATATGAAAAAGCAGAGC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatGACTCGGTTAAGGGAAAGCGCCGAGATGACGGGCTTTCTGCTGC

CGCCCGCAAGCAGAGGTAGCCCCAGGGAGGGGAGGGAAAGGGACGGTGGA

GACCTGGGTTAGACCAAGGGTTATAGAAGGAAAGAGAGCTACCTCAGGGC

TTGAATGTGGACTAGTCGTGAGGAGCAGAGTGCATTGCTTCCTCTAGGGT

TTTATTTCCTCCCCACCCTCCAAATTGTTAGCTCACAGCCTTACAGGAAA

GGACGGGGGCGGGCGCCTGCCCTCAGTCTGATTTCTGAGCGTCCCTGGGT

CTGACCTTAAGGGCAAGGGCAGGGAGCTTCACATTTCAAATACAGTTGTG

GTTACGGCAGCCCAGTACTTTTGGCCCTCCTTGCTGTTCGGTTCTCCTCC

CTTCTCCCAACCTCCTCACTGGTGTTGCTGGGTGTGGTCCTCAATACAGA

ATAGAG

(SEQ ID NO: 168)

pARBI-949:
AATCGAGCCCTTTGCCCACGGCTACTTCACGGGACCACCCTCCCGGGTTA
1806

SERF2_2_
GGCATAGGCCCTCCCGGATCTTCCGCGGTGTAAGGAGAAGGCCAGCGCCC

Endogenous_
CTGTGATAGGCCCAGAGCCCCCACTCCACAAGCCAGCCCATCCCCCACGG

53_54
AGACCCAAACCGTCCACACACACCTTGCCAGCTGTTTGGGCCCCACGCCG

CCCCAAAACACGCCTCCAGCTGGCCCCTTGGGACCTCCCTTCTCTAGTCC

GTATTTTGACCTGGCCCGTGGCAGATTCGCCACTCCCCCCTACCCCAAGC

AGCCTGGGCCTCGATGGGCCGTTGTCGGGGCCCGGAGATTGAAGTGGTGT

TGGATCCTGCTGCTGGCCGCGCTGGGGTAGAAGGGTCGCCGGTGTGTGGG

CAGAGCGGCCCCCGCGTCTCACCTTTAATTTTCTTTCCTTAGGCGGTAAC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatCAGCGCGAGCTTGCCCGCCAGAAGAATATGAAAAAGCAGAGCGA

CTCGGTTAAGGGAAAGCGCCGAGATGACGGGCTTTCTGCTGCCGCCCGCA

AGCAGAGGTAGCCCCAGGGAGGGGAGGGAAAGGGACGGTGGAGACCTGGG

TTAGACCAAGGGTTATAGAAGGAAAGAGAGCTACCTCAGGGCTTGAATGT

GGACTAGTCGTGAGGAGCAGAGTGCATTGCTTCCTCTAGGGTTTTATTTC

CTCCCCACCCTCCAAATTGTTAGCTCACAGCCTTACAGGAAAGGACGGGG

GCGGGCGCCTGCCCTCAGTCTGATTTCTGAGCGTCCCTGGGTCTGACCTT

AAGGGCAAGGGCAGGGAGCTTCACATTTCAAATACAGTTGTGGTTACGGC

AGCCCAGTACTTTTGGCCCTCCTTGCTGTTCGGTTCTCCTCCCTTCTCCC

AACCTC

(SEQ ID NO: 169)

pARBI-950:
TTCAAAAGGAATCTTTTTGTTTCAACTATTAGGATCTTTTTAAATCAAAT
1806

SLC38A1_1_
ATGTATTTTAATGGTGTACACCAGACCTGAAGAAAAAGATCACAGAAGGA

Endogenous_55
ATTTCCCCTTTGTAAGATAGAGGTAGTTAAAAATAAGCCTTATGACCTAA

TAGGTTAATTGTAATGCTCTGGTAGCCAACTTGAAAAAGGAGAAATGATG

GTTGCATCTCACATTTTAAAATGTTAAGAATTTGTTTTGTAATGAGGATA

CCTTAACCCCTGAAGGCCAAAATGACTATTTGTGTGAGTTTGAGAAAGGC

ACATAGTAACTTGGGGAACAGTCAATAGAATGACAAAATCTTGACTATTT

TAACTTTCTGAACCCTGTCATTTCTTGTGTTCTCAAATTTGATTTTTAAA

TAGGCTGCATGGTGTATGAAAAGCTGGGGGAACAAGTCTTTGGCACCACA

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatGGGAAGTTCGTAATCTTTGGAGCCACCTCTCTACAGAACACTGG

AGGTAAAAAGAACATGCTTTTCTTTACATAACTTGAAACTAATTCTGGTG

GATGAGCGGCCACATGAATTTTAACATAATTCAAGCAGTTATCATCCTCA

TTGCTAAAATGGCACAGGGAAAGTAAAGCAGAGACAGCAGTCACTTATTT

AAAGCCACAAATCCTGCTAGAGTAGCTGAAGTTGCCTTTGTGTCTTACTG

ACAGTTGGTCTAAGAACGGGCTGATAACTTTTTATGTAGCTTGCAACATA

AGCCTTCGTATCTTCTTTCTAAAAATGTTCTCATTTTCCTTCAGCAATGC

TGAGCTACCTCTTCATCGTAAAAAATGAACTACCCTCTGCCATAAAGTTT

CTAATGGGAAAGGAAGAGACATTTTCGTAAGTTATAGACCATTTTTTTAT

GATATA

(SEQ ID NO: 170)

pARBI-951:
TAAAGATGTCAAGCTTCAAATCATTATCATAAGGTTAAATATATTACGCA
1806

SLC38A1_2_
TGTCTTTACAGCAAGTTTATTTCTGATCGTGAAAGTAGAAGAAGTCTCAC

Endogenous_56_57
AAACAGCCATTTGGAAAAAAAGAAGTGTGATGAGTATGTAAGTATCATTA

TAATGAAGTATGCTTATTTTTTTAATCATATAAATTGGGACAAATCTTTT

TAATTCAAGTAGCATAGTACCAAAAGCATAACTACCTGTATTCACCAGGA

TATTCCTCATACCTTATGTATTTTCTCTTGAAATCCATTCAAGGAAATAA

CTAGATAACTAAGAATGGATTTTCTTGAATTTTACTTCCATATTGGTTCC

TGAGAGTGCATTAAAGGCTTTGGCTTGATGAACTTTCTTGGGGATTATTT

TGCTTAGTGTCAATGTTTGTTTCTTTGTTCAGATTCCAGGTACAACCTCC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatTTAGGCATGTCAGTTTTTAACCTAAGCAACGCCATTATGGGCAG

TGGGATTTTGGGACTCGCCTTTGCCCTGGCAAACACTGGAATCCTACTTT

TTCTGTGAGTATTGACGTGCCGGTACTTTCCATTTTAAAACTGAACTTTT

TGTATGTTTCTGTTATTACATAGAAGAAATGTGAAATATTTATAAATAGT

TTTTTTATTAACTTGGCTAAGTTACAAGTACATACTTTGATATTTATTGC

TTGAGTGATTTTCCAAACTGTACCTAATGCTTACAACAAAGAGGAAGGAG

AAAATCTTTTTATTAATCAAAAATACTGAAATAAGCATTTGTGAAAAGGA

TTAAAACATTTGAAAATAACTTTTTTTGGTATTTTTGGAGTCTACCTGTG

ACTTTAAATCTCAGTTAAAATATTAAGAGGTGTTTAACCCCAGCCAGTCA

CCACTT

(SEQ ID NO: 171)

pARBI-952:
ATCATTCTTCACACTAGTTCCTTTTCTGACTCTTCAGTCACCTCCAGAAT
1806

SMAD2_1_
TAATATCCTTAGAAGCATCTCTAAAATGAGTTTGATTTACTAAACATAGA

Endogenous_58
AGTTGACAAAGTTTTTCAAGTATAACTGCATAAACTCTCTTTTTTAAAAA

ATCAGTTTTTCCCAAGTTGTTAGCCTTTCATTGGCATTTGAGTCATTTAT

GTGACATATTTATAAGAAACATCTGCTAGTGCTGCTGCATACTTTTATCA

GATCCATTAAATAGTACATTTTTGTTCTTGATTCTCACTAAAACTAACTA

AATGGCTGTCATTCTTTTCTTTATGCTTTTATTGTACTAATTTAGCCCAT

TTGACTGCACttttttttttttttttttAAAGTTCCCTCCTTTCTTTTCC

CCTTGCTTCCCAACAGGTCTCTTGATGGTCGTCTCCAGGTATCCCATCGA

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatAAAGGATTGCCACATGTTATATATTGCCGATTATGGCGCTGGCC

TGATCTTCACAGTCATCATGAACTCAAGGCAATTGAAAACTGCGAATATG

CTTTTAATCTTAAAAAGGATGAAGTATGTGTAAACCCTTACCACTATCAG

AGAGTTGAGACACCAGGTAGGAATATTGCAAGTTTTTTTCTTGGTTTTGA

ATTAAATGCCTGAACTTCAGTATATTTAAGTACTCTTGTGACCCAGGAAA

ATTTTAGTGTAAATTCTAATAAATTACCTTAAATTGTGCATATTATTTGG

TGGTAATTAAAAtttttttatttttaaaaatttttAATGAGAAAACATAT

CTGTTTCTTGGAATAGCATATGATTTGGCATGAAAGTGCATATCCAGGAA

ATCCTGTAGATTGGCAGTCTGCTCAGCGCTATGCTGATGTGCTTCTACAT

GTCCCT

(SEQ ID NO: 172)

pARBI-953:
TTCTATATTAAAAATCAGTTGACATCTGTTTTTAGATAATTTTTTAAAAA
1806

SMAD2_2_
ACTGGATTATAAAATGAAGCACTTAGTAAAGCTGATGGCAGAGGTTTTAG

Endogenous_59
ATCTTTTGAATACAGGAAAGTGGTAAGGGCATTATAGGTATGATTCATTG

AGCTAGAGGGCGTTGGTGTTCACATTTTAAAAACATAATCATGACTTATC

TGGAGTCACATGTTCCATTTTATTGGCTTCCTTCATATAGAAAATATAGT

AACCAGCACTACATGCCTGTGAAAAAGTGAAGCAATTGTATATTTTCTGG

GTGAAGGAAGTATTCTGTACATTCTCCATGTTTTACATCATGGTATTTTG

AATAACCATGCTTCCATGTTCACATCAATTTTTTGTTTTTCAATTTATGC

ACAGCACTTGCTCTGAAATTTGGGGACTGAGTACACCAAATACGATAGAT

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatCAGTGGGATACAACAGGCCTTTACAGCTTCTCTGAACAAACCAG

GTGAATATTCTGCCCTCTGTCGAATCTTAGAGATCTTGTGGGAGGGGGGT

ATATTTTGAAAGACCTATATGGGGTTGCTTAGTATAATTTTGCCTAGGAT

GTTTCCTTAATGTAAAATAAGGCATAGCATTTAAAATATCTGCTTGCCAG

TATAAAAAATATATTAAATGTTTCAGCTGATGTTTTAATCAATGCAATTC

TAGTTTGAATCTTCTTTAAATTACTGTATCCCCTAAAGAATAATAATTTT

GATAACTATATATTTATTTTAGCTTGAGATCAGATTATAATCTGTTGTTG

GCCTAATTTTTAAGTAGATACATGATGAGTTTTGCTAAATTTCTTGTTAT

CAGAATCTCATCTTTATACTAATAAATACATACTTAATGAACCCCTTATA

TCACAA

(SEQ ID NO: 173)

pARBI-954:
TCAATGTATTTTTGTATAGTCTTTTGAGATTAGAGTGAAGTTCTAAAAAG
1806

SMAD2_3_
TAAGAGAACCTTTTGTGAAAATATTTTAATTGACACTACTAAGAGTTTAA

Endogenous_60
AATAGTATTGGTGGTGAAAAATCGTTAAAAGTATCTGATTTTACTTGCAA

AATTACTGTATTTTCCCACAAGAGGAGTCCTTACAACATTCTTGTTTTTA

GAAGGGTTTGTTTCCATCATTCATTTAAATTCATAAAGATAACGTTTTCA

TGGGTGGAGAAGTCTATTGGGAAAGTCATAATTCGAATTTCTATCTTGCT

TTGCAGTTTGCTTTCTATGATAAGTTGAAATTATTACTTGATGTTCAAGG

TAGTCTCTACATCATCCTTTCAATATTTCTGCTAGGTTCGATACAAGAGG

CTGTTTTCCTAGCGTGGCTTGCTGCCTTTGGTAAGAACATGTCGTCCATC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatTTGCCATTCACGCCGCCAGTIGTGAAGAGACTGCTGGGATGGAA

GAAGTCAGCTGGTGGGTCTGGAGGAGCAGGCGGAGGAGAGCAGAATGGGC

AGGAAGAAAAGTGGTGTGAGAAAGCAGTGAAAAGTCTGGTGAAGAAGCTA

AAGAAAACAGGACGATTAGATGAGCTTGAGAAAGCCATCACCACTCAAAA

CTGTAATACTAAATGTGTTACCATACCAAGGTAAGTTTTGTTAGATCCCA

GGTTTGATCAAATTATGTCAAGGAATCTGAAGGAAAGTTACTGAATTTGT

GTTCCTTTCAAGTTGCCTGTAAAAAGTGATGATTGAAATATGACTGTTTT

TAACCTTGTATAAATTGTTTTTGCTAGCTGACTTGTTTTATAAATTATTT

TCTTGAATAGTGAGGTTTAATCAAGCTAAATAAGATACTTAGATTTATTA

TCTTCA

(SEQ ID NO: 174)

pARBI-955:
GGGCTCCCGCAGCACAGCCTTTCTCCGGCCCTAGCCCAAATCGCCCAGAC
1806

SOCS1_1_
CAGGCGCGGATCCCAGCCTGGCCAGCAGGCGGCGGGCGCGGGGGGCGAGC

Endogenous_61
CGGGGCCGGACGGCTGGAGCCAGAACCGGCTGCTCTCCACGCCCCCCTCT

CGGTGCTGCCCGGAGGCCGGACTCCGCCTCCACCGAGCCCCCACCCGCCG

GGAAGAGCTCCGCGGAGTACAGAGCCCATTTTCTAGCTGTGTCCACTGAG

GCTGAACGGATCCGCGCGGACTTGGTGCTCCGTGCTCGCCCCCTAGGGCC

GGGTCCGCCGGGAGCGCCGCCCTCCGGAGTTGTCCGGCCGGCGCACACCT

GCCCGGCCCCGCAGCGCCCCAGCTCACCTCTTTGTCTCTCCCGCAGCGCA

CCCCCGGACGCTATGGCCCACCCCTCCGGCTGGCCCCTTCTGTAGGATGt

ccggatccggagagggcaggggatctctccttacttgtggcgacgtggag

gagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGT

GGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCA

GCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTG

AAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGT

GACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACA

TGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAG

GAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCGA

GGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCA

TCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAAC

TACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCAT

CAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAGC

TCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTG

CTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCC

CAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCG

GGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagct

tataatggttacaaataaagcaatagcatcacaaatttcacaaataaagc

atttttttcactgcattctagttgtggtttgtccaaactcatcaatgtat

cttatGTAGCACACAACCAGGTGGCAGCCGACAATGCAGTCTCCACAGCA

GCAGAGCCCCGACGGCGGCCAGAACCTTCCTCCTCTTCCTCCTCCTcgcc

cgcggcccccgcgcgcccgcggccgtgccccgcggtcccggccccggCCC

CCGGCGACACGCACTTCCGCACATTCCGTTCGCACGCCGATTACCGGCGC

ATCACGCGCGCCAGCGCGCTCCTGGACGCCTGCGGATTCTACTGGGGGCC

CCTGAGCGTGCACGGGGCGCACGAGCGGCTGCGCGCCGAGCCCGTGGGCA

CCTTCCTGGTGCGCGACAGCCGCCAGCGGAACTGCTTTTTCGCCCTTAGC

GTGAAGATGGCCTCGGGACCCACGAGCATCCGCGTGCACTTTCAGGCCGG

CCGCTTTCACCTGGATGGCAGCCGCGAGAGCTTCGACTGCCTCTTCGAGC

TGCTG

(SEQ ID NO: 175)

pARBI-956:
GGATCCCAGCCTGGCCAGCAGGCGGCGGGCGCGGGGCGGCGAGCCGGGGC
1806

SOCS1_2_
CGGACGGCTGGAGCCAGAACCGGCTGCTCTCCACGCCCCCCTCTCGGTGC

Endogenous_62
TGCCCGGAGGCCGGACTCCGCCTCCACCGAGCCCCCACCCGCCGGGAAGA

GCTCCGCGGAGTACAGAGCCCATTTTCTAGCTGTGTCCACTGAGGCTGAA

CGGATCCGCGCGGACTTGGTGCTCCGTGCTCGCCCCCTAGGGCCGGGTCC

GCCGGGAGCGCCGCCCTCCGGAGTTGTCCGGCCGGCGCACACCTGCCCGG

CCCCGCAGCGCCCCAGCTCACCTCTTTGTCTCTCCCGCAGCGCACCCCCG

GACGCTATGGCCCACCCCTCCGGCTGGCCCCTTCTGTAGGATGGTAGCAC

ACAACCAGGTGGCAGCCGACAATGCAGTCTCCACAGCAGCAGAGCCCCGA

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatCGGCGGCCAGAACCTTCCTCCTCTTCCTCCTCCTcgcccgcggc

ccccgcgcgcccgcggccgtgccccgcggtcccggccccggCCCCCGGCG

ACACGCACTTCCGCACATTCCGTTCGCACGCCGATTACCGGCGCATCACG

CGCGCCAGCGCGCTCCTGGACGCCTGCGGATTCTACTGGGGGCCCCTGAG

CGTGCACGGGGCGCACGAGCGGCTGCGCGCCGAGCCCGTGGGCACCTTCC

TGGTGCGCGACAGCCGCCAGCGGAACTGCTTTTTCGCCCTTAGCGTGAAG

ATGGCCTCGGGACCCACGAGCATCCGCGTGCACTTTCAGGCCGGCCGCTT

TCACCTGGATGGCAGCCGCGAGAGCTTCGACTGCCTCTTCGAGCTGCTGG

AGCACTACGTGGCGGCGCCGCGCCGCATGCTGGGGGCCCCGCTGCGCCAG

CGCCGC

(SEQ ID NO: 176)

pARBI-957:
CGGACTCCGCCTCCACCGAGCCCCCACCCGCCGGGAAGAGCTCCGCGGAG
1806

SOCS1_3_
TACAGAGCCCATTTTCTAGCTGTGTCCACTGAGGCTGAACGGATCCGCGC

Endogenous_63
GGACTTGGTGCTCCGTGCTCGCCCCCTAGGGCCGGGTCCGCCGGGAGCGC

CGCCCTCCGGAGTTGTCCGGCCGGCGCACACCTGCCCGGCCCCGCAGCGC

CCCAGCTCACCTCTTTGTCTCTCCCGCAGCGCACCCCCGGACGCTATGGC

CCACCCCTCCGGCTGGCCCCTTCTGTAGGATGGTAGCACACAACCAGGTG

GCAGCCGACAATGCAGTCTCCACAGCAGCAGAGCCCCGACGGCGGCCAGA

ACCTTCCTCCTCTTCCTCCTCCTcgcccgcggcccccgcgcgcccgcggc

cgtgccccgcggtcccggccccggCCCCCGGCGACACGCACTTCCGCACA

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatTTCCGTTCGCACGCCGATTACCGGCGCATCACGCGCGCCAGCGC

GCTCCTGGACGCCTGCGGATTCTACTGGGGGCCCCTGAGCGTGCACGGGG

CGCACGAGCGGCTGCGCGCCGAGCCCGTGGGCACCTTCCTGGTGCGCGAC

AGCCGCCAGCGGAACTGCTTTTTCGCCCTTAGCGTGAAGATGGCCTCGGG

ACCCACGAGCATCCGCGTGCACTTTCAGGCCGGCCGCTTTCACCTGGATG

GCAGCCGCGAGAGCTTCGACTGCCTCTTCGAGCTGCTGGAGCACTACGTG

GCGGCGCCGCGCCGCATGCTGGGGGCCCCGCTGCGCCAGCGCCGCGTGCG

GCCGCTGCAGGAGCTGTGCCGCCAGCGCATCGTGGCCACCGTGGGCCGCG

AGAACCTGGCTCGCATCCCCCTCAACCCCGTCCTCCGCGACTACCTGAGC

TCCTTC

(SEQ ID NO: 177)

pARBI-958:
GGCAGACAAACAGTTAAAACAGAGGAGTGGGGTAAGTGATGACCTAACCC
1806

SRP14_1_
AGCCCCGCTGCTCTAGTTTTGTTAAACACCTCATCTGCTATCACGGTCTG

Endogenous_64
GCGAAACCCTGGAGAAACTATTATTTCCACGACGGAAACATGTAATATCG

AAGCACGTTAAATTCCACTCAAAGTGGCGGCGTCTGGGATCCCTGACAAA

GAGCCCTGGGCTGCTTGGGGCCCATTGTTACCAGAAGCAACCTAGGCGGC

TCAGTGCTGGGGACTGAGCCAGCTACAATCCCTACTATTTTCCGGGCCCG

AAGCCCCGAATGTGCTCAGTACAGGGTGGGGAAAGGTAGAGGAAGGCGGC

GGTCCGCGGCAGACAGACTCCGGTGGCTCCCAGACACCGGGAACCCAGGG

AGCATCGCCCGGCTCCCCTCCCGCTGCTTACACTTCTTCAAGGTGATATA

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatGACGCTGCCCGACGTCCGGCACTTCTGGAAAAGTCTGGTCAGCT

CCGTCAGGAACTGGAAAACAACAGGCCCAGCCCCGTTAGCCAGCCCCAAA

TCCTCGTCCTGCCGCGTCAAGGCCCTGGTCCTCCTGCAGGAGGCACAGGT

CTCGAGTAACGCCTGAGCCGCCCCCTTCCCTCGGCCGGCCAGGCCTAGCC

ATACCTGCTCGCTCTCCAACAACACCATCGCGGCGACGCTGGCTCGACTC

CCTCCGCTTAAGCCCCTAGCAGTGAGAGCCGGAAGTTCGGCCTAGGCTGG

GGGGACTTCCGCTACTAGACTTCCATTGTCTTCCACCAATCTCTTCTCTT

CCACCAATCCCGGCCTGCGCCCTCCCCCCTCCCCGCCCGCCTAGCGCCCG

CGCCCTGGGACGTCCGGGGGCCTGTGACCCGGAGGCGCTGGGGCTGTCCT

GGGTC

(SEQ ID NO: 178)

pARBI-959:
GTCTGTCTGCCGCGGACCGCCGCCTTCCTCTACCTTTCCCCACCCTGTAC
1806

SRP14_2_
TGAGCACATTCGGGGCTTCGGGCCCGGAAAATAGTAGGGATTGTAGCTGG

Endogenous_
CTCAGTCCCCAGCACTGAGCCGCCTAGGTTGCTTCTGGTAACAATGGGCC

65_66
CCAAGCAGCCCAGGGCTCTTTGTCAGGGATCCCAGACGCCGCCACTTTGA

GTGGAATTTAACGTGCTTCGATATTACATGTTTCCGTCGTGGAAATAATA

GTTTCTCCAGGGTTTCGCCAGACCGTGATAGCAGATGAGGTGTTTAACAA

AACTAGAGCAGCGGGGCTGGGTTAGGTCATCACTTACCCCACTCCTCTGT

TTTAACTGTTTGTCTGCCGCTCAGCCACGTACGCGGCCGTGTTCACCAGG

ATGCATTTTTTCCTTCAGATGACGGTCGAACCAAACCCATTCCAAAGAAG

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatGGTACTGTGGAGGGCTTTGAGCCCGCAGACAACAAGTGTCTGTT

AAGAGCTACCGATGGGAAGAAGAAGATCAGCACTGTGGTGAGCTTAATTT

CTAAGGCTGTCTTTTGAAATGTAAAGACTTGAACTTAACAGAGGATGGGG

CGTTTCTGAACCAGGCTTTTATTTGTTTTTCCCTTTTGCCCTGTGTGGCT

ATTTTTGAGACCAGGACCTTCCTATACTTTAGTAGTGGAAACCTCAAGAA

TAAAATAAGAAGGTAGAGGTCAGACAGTCGTTAGTTCTGCTAAAGCTCTT

GTGGAAATGAAAGTAGCATATTGGTCCTTATTCGTAGTACTGTAAGGAGC

AGCTGGCATAAATATTTGATTCCTTAGCCCCTTACTGTGCTGGGCCTTCA

ATAAGCAGTTTCTTGGTACCAGGTGATGCTATTATTTCCTTATCTTTGTG

GTTCAC

(SEQ ID NO: 179)

pARBI-960:
CCCACGTCAGTGAGTGCTCACAAGTCTGTGAGGTAGGCGGCGCCACAGAG
1806

SRSF9_1_
AGAAACTGAGGCGCGGGAGCCCAAGCCACTTGTCCAGCGCCTCAGCCGAG

Endogenous_67
CGCGAACCGCGCTCGGGGATGGCATCCACACGGCCCGGCCCCAGGCTCTC

CCTGTCAGCGCCCGAAGGCCCTTCGCACCTCCAGGGGGCGCCGGCCTGCG

CGCACGCGCAATGGTCGCAGCCGCGTTCTCTTTAAGAGGACTCCTTTTGC

CTCCGCCGACCCCTTCGCTTCCGCTCCGCGTTCCCACAATGCAGTGCGGC

TGAGCGCCTCGGAGCCCGCGGGGACGCTGCGGGGGGACCCGTGCTGAggc

ggcggcggcgacgtgggctgcggcgggcccgcggcgtcgggcggtgcgga

tgtcgggctgggcggacgagcgcggcggcgAGGGCGACGGGCGCATCTAC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatGTGGGGAACCTTCCGACCGACGTGCGCGAGAAGGACTTGGAGGA

CCTGTTCTACAAGTACGGCCGCATCCGCGAGATCGAGCTCAAGAACCGGC

ACGGCCTCGTGCCCTTCGCCTTCGTGCGCTTCGAGGACCCCCGGTGAGGc

ccccgcgcccctgccctctcctcctcggtgcctgaggcccccgccttccc

tgctgtcccctcccccagggctcccctccccccggcctcccctccccccg

cctccgcgcagacccctcaCGGCGCCCCCTCACGGGTGGAGGATGAGGCA

GCCTCTCCTCGCAGGCCCGGGCCGTCCTTCGCGCCGTCGTCACTTCCTTT

ATTTTTATTATTCCAATATTTTACTTAGAAACCCAAAAGCTGAGCCTTTG

GAGGGCCCAAGCCCGCCTGCACCGGCCTCGGGGGGTCCAAATGAGCCTTG

TCCGCC

(SEQ ID NO: 180)

pARBI-961:
TGTGGTGTGCTTTTCGAGAAAATGCTCACGAAGATTAGAAAAACACTGAT
1806

SRSF9_2_
GGTTTATTGGCAAAATCAATAATCTGTCAGCAGTTGATTCttttttttCT

Endogenous_68
CTGAATTAGCCCTCTTATGAGTAATCTGTTTGCTCATTCATTATAATTTC

ATACCTCTAAAACTGCGTGTGACAGCTGTAAAGGTTAATTCCAGTATCAT

GAAACGTCTCCAAACCAAAGCAGAAGTGCTTCAGGATCCTGATTTGTGTG

TTTTTTTCTTCACTCTAGGTTTCCCTTTTATGCTTACTACTCATGCCCCT

CACTTGGAAAGTCACTTGGCCTCCTGAACAGCACTAACTCCAAACGtttt

ttttgttgttgttgttttttttAGAGATGCAGAGGATGCTATTTATGGAA

GAAATGGTTATGATTATGGCCAGTGTCGGCTTCGTGTGGAGTTCCCCAGG

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatACTTATGGAGGTCGGGGTGGGTGGCCCCGTGGTGGGAGGAATGG

GCCTCCTACAAGAAGATCTGATTTCCGAGTTCTTGTTTCAGGTATGTTCC

TTTCAAACAGaatgagatgatacatgtaaaatacttaacacagagtctgt

cttccaagaaatgatagctgttattcttCAGTGCATGGGACACGGGGGCT

TTCTTTTCAATAGCCTGTGTGAAGCCTTGCCCTGGATTGCCAATGAGGAA

AGTATCCTGCAAATGAAATTGCGCTGGGAGTGCAGCCTTGGAAGAACATA

ACCATATTTCTTGTAAAGGAGTTTTCTAGTGGTGAGAAGGAAAGATGATG

GGAAAACTTGAGCTACAATTCTAAAGATGCTTCTTTTGGAATATACTTGG

CATCAGACATGGTAGAAAGGCATTCAAGGAGCCAGATTTGAACAACTTAC

CCAGCC

(SEQ ID NO: 181)

pARBI-962:
GATGGCATCCACACGGCCCGGCCCCAGGCTCTCCCTGTCAGCGCCCGAAG
1806

SRSF9_3_
GCCCTTCGCACCTCCAGGGGGCGCCGGCCTGCGCGCACGCGCAATGGTCG

Endogenous_69
CAGCCGCGTTCTCTTTAAGAGGACTCCTTTTGCCTCCGCCGACCCCTTCG

CTTCCGCTCCGCGTTCCCACAATGCAGTGCGGCTGAGCGCCTCGGAGCCC

GCGGGGACGCTGCGGGGGGACCCGTGCTGAggcggcggcggcgacgtggg

ctgcggcgggcccgcggcgtcgggcggtgcggatgtcgggctgggcggac

gagcgcggcggcgAGGGCGACGGGCGCATCTACGTGGGGAACCTTCCGAC

CGACGTGCGCGAGAAGGACTTGGAGGACCTGTTCTACAAGTACGGCCGCA

TCCGCGAGATCGAGCTCAAGAACCGGCACGGCCTCGTGCCCTTCGCCTTC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatGTGCGCTTCGAGGACCCCCGGTGAGGcccccgcgcccctgccct

ctcctcctcggtgcctgaggcccccgccttccctgctgtcccctccccca

gggctcccctccccccggcctcccctccccccgcctcegcgcagacccct

caCGGCGCCCCCTCACGGGTGGAGGATGAGGCAGCCTCTCCTCGCAGGCC

CGGGCCGTCCTTCGCGCCGTCGTCACTTCCTTTATTTTTATTATTCCAAT

ATTTTACTTAGAAACCCAAAAGCTGAGCCTTTGGAGGGCCCAAGCCCGCC

TGCACCGGCCTCGGGGGGTCCAAATGAGCCTTGTCCGCCTCCTGCCTGGG

GCAGCACCGTAGGGGGAAGCGGCCGCGGGGCAGCGCGGGGGTCGCCGTTC

GCCCTTCCCGCTCGCCTCTCCCCCGGCCCGTGCTCGCCGTGGCTGGAGAG

CAAGCT

(SEQ ID NO: 182)

pARBI-963:
GTAACTGACTAGCCTTAGTAGACTGTGGTTTCCAGGTTTATTCAGAAGTA
1806

SUB1_1_
GCAAGATCCCTCCAtttttttttCTACCAAAGAAATCGTATGTGGGATCC

Endogenous_70
CAAACCACAAAATAACCGTTCCTGTGGTTAATACTACTATAATGCCTGAA

GTGTCTTTTGGGATCCTGAGAACAGAGTTTGAAAACATTACTAGACAGAA

GGATTGGTTAGATTCATAGTTTTGTTGTTGAGTGAAACTTGCTTATGTAT

ATATTTATGATATTTTGGATGTAGTCTTTTGATTGTTTAAATCTTAAAAA

GTAATGGGATCTTTTGACACTGGGGTATGTTTTATTTTTATGTGTGCAAA

TTTTAACCATATTCTTTTCTAGTTAAAGAGGAAAAAGCAAGTTGCTCCAG

AAAAACCTGTAAAGAAACAAAAGACAGGTGAGACTTCGAGAGCCCTGTCA

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatTCTTCTAAACAGAGCAGCAGCAGCAGAGATGATAACATGTTTCA

GGTAAAGTTGGCTAttttttttttttttttttttgacatggagtcatgct

ctgtcacccaggctggagtgcagtggcgccatctcggctcactgcaacct

cagcctcctgagttcaagcagttctctgcctcagcctcccgagtagctag

gattacaggcatccgccaccagacctggctaatttttgtatttttagtag

agatggggtttcaccatcttggccaggctggtcttgaactcctgaccttg

tgatccaactgcctcagcctccaaaagtgctgggtttacaggtgtgagcc

accatgccttgccAAAGTTGGCTGTTTCTTTAGATTCAGAGGAATTATTA

TCTGGCTTGATCTGAAGAATGTTAAAAGTACTATGATCTGATAATTGCCT

AATATG

(SEQ ID NO: 183)

pARBI-964:
ATAAATAAACATATCCTGGAAATGGAATAAGTTGGTTATATTCTTTTTAA
1806

SUB1_2_
TTAGTATATCTGCTTCGTAAAATAAGTAACTGACTAGCCTTAGTAGACTG

Endogenous_71
TGGTTTCCAGGTTTATTCAGAAGTAGCAAGATCCCTCCATTTTTTTTTCT

ACCAAAGAAATCGTATGTGGGATCCCAAACCACAAAATAACCGTTCCTGT

GGTTAATACTACTATAATGCCTGAAGTGTCTTTTGGGATCCTGAGAACAG

AGTTTGAAAACATTACTAGACAGAAGGATTGGTTAGATTCATAGTTTTGT

TGTTGAGTGAAACTTGCTTATGTATATATTTATGATATTTTGGATGTAGT

CTTTTGATTGTTTAAATCTTAAAAAGTAATGGGATCTTTTGACACTGGGG

TATGTTTTATTTTTATGTGTGCAAATTTTAACCATATTCTTTTCTAGTTA

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatAAGAGGAAAAAGCAAGTTGCTCCAGAAAAACCTGTAAAGAAACA

AAAGACAGGTGAGACTTCGAGAGCCCTGTCATCTTCTAAACAGAGCAGCA

GCAGCAGAGATGATAACATGTTTCAGGTAAAGTTGGCTATTTTTTTTTTT

TTTTTTTTTGACATGGAGTCATGCTCTGTCACCCAGGCTGGAGTGCAGTG

GCGCCATCTCGGCTCACTGCAACCTCAGCCTCCTGAGTTCAAGCAGTTCT

CTGCCTCAGCCTCCCGAGTAGCTAGGATTACAGGCATCCGCCACCAGACC

TGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATCTTGGCCA

GGCTGGTCTTGAACTCCTGACCTTGTGATCCAACTGCCTCAGCCTCCAAA

AGTGCTGGGTTTACAGGTGTGAGCCACCATGCCTTGCCAAAGTTGGCTGT

TTCTTT

(SEQ ID NO: 184)

pARBI-965:
AATTAGTATATCTGCTTCGTAAAATAAGTAACTGACTAGCCTTAGTAGAC
1806

SUB1_3_
TGTGGTTTCCAGGTTTATTCAGAAGTAGCAAGATCCCTCCATTTTTTTTT

Endogenous_72
CTACCAAAGAAATCGTATGTGGGATCCCAAACCACAAAATAACCGTTCCT

GTGGTTAATACTACTATAATGCCTGAAGTGTCTTTTGGGATCCTGAGAAC

AGAGTTTGAAAACATTACTAGACAGAAGGATTGGTTAGATTCATAGTTTT

GTTGTTGAGTGAAACTTGCTTATGTATATATTTATGATATTTTGGATGTA

GTCTTTTGATTGTTTAAATCTTAAAAAGTAATGGGATCTTTTGACACTGG

GGTATGTTTTATTTTTATGTGTGCAAATTTTAACCATATTCTTTTCTAGT

TAAAGAGGAAAAAGCAAGTTGCTCCAGAAAAACCTGTAAAGAAACAAAAG

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatACAGGTGAGACTTCGAGAGCCCTGTCATCTTCTAAACAGAGCAG

CAGCAGCAGAGATGATAACATGTTTCAGGTAAAGTTGGCTATTTTTTTTT

TTTTTTTTTTTGACATGGAGTCATGCTCTGTCACCCAGGCTGGAGTGCAG

TGGCGCCATCTCGGCTCACTGCAACCTCAGCCTCCTGAGTTCAAGCAGTT

CTCTGCCTCAGCCTCCCGAGTAGCTAGGATTACAGGCATCCGCCACCAGA

CCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATCTTGGC

CAGGCTGGTCTTGAACTCCTGACCTTGTGATCCAACTGCCTCAGCCTCCA

AAAGTGCTGGGTTTACAGGTGTGAGCCACCATGCCTTGCCAAAGTTGGCT

GTTTCTTTAGATTCAGAGGAATTATTATCTGGCTTGATCTGAAGAATGTT

AAAAGT

(SEQ ID NO: 185)

pARBI-966:
CACATTTTAATTTTTGTTTCCATGCTCTTTAGAATTCAACTAGAGGGCAG
1806

TET2_1_
CCTTGTGGATGGCCCCGAAGCAAGCCTGATGGAACAGGATAGAACCAACC

Endogenous_73
ATGTTGAGGGCAACAGACTAAGTCCATTCCTGATACCATCACCTCCCATT

TGCCAGACAGAACCTCTGGCTACAAAGCTCCAGAATGGAAGCCCACTGCC

TGAGAGAGCTCATCCAGAAGTAAATGGAGACACCAAGTGGCACTCTTTCA

AAAGTTATTATGGAATACCCTGTATGAAGGGAAGCCAGAATAGTCGTGTG

AGTCCTGACTTTACACAAGAAAGTAGAGGGTATTCCAAGTGTTTGCAAAA

TGGAGGAATAAAACGCACAGTTAGTGAACCTTCTCTCTCTGGGCTCCTTC

AGATCAAGAAATTGAAACAAGACCAAAAGGCTAATGGAGAAAGACGTAAC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatTTCGGGGTAAGCCAAGAAAGAAATCCAGGTGAAAGCAGTCAACC

AAATGTCTCCGATTTGAGTGATAAGAAAGAATCTGTGAGTTCTGTAGCCC

AAGAAAATGCAGTTAAAGATTTCACCAGTTTTTCAACACATAACTGCAGT

GGGCCTGAAAATCCAGAGCTTCAGATTCTGAATGAGCAGGAGGGGAAAAG

TGCTAATTACCATGACAAGAACATTGTATTACTTAAAAACAAGGCAGTGC

TAATGCCTAATGGTGCTACAGTTTCTGCCTCTTCCGTGGAACACACACAT

GGTGAACTCCTGGAAAAAACACTGTCTCAATATTATCCAGATTGTGTTTC

CATTGCGGTGCAGAAAACCACATCTCACATAAATGCCATTAACAGTCAGG

CTACTAATGAGTTGTCCTGTGAGATCACTCACCCATCGCATACCTCAGGG

CAGATC

(SEQ ID NO: 186)

pARBI-967:
AATGGAGAAAGACGTAACTTCGGGGTAAGCCAAGAAAGAAATCCAGGTGA
1806

TET2_2_
AAGCAGTCAACCAAATGTCTCCGATTTGAGTGATAAGAAAGAATCTGTGA

Endogenous_74
GTTCTGTAGCCCAAGAAAATGCAGTTAAAGATTTCACCAGTTTTTCAACA

CATAACTGCAGTGGGCCTGAAAATCCAGAGCTTCAGATTCTGAATGAGCA

GGAGGGGAAAAGTGCTAATTACCATGACAAGAACATTGTATTACTTAAAA

ACAAGGCAGTGCTAATGCCTAATGGTGCTACAGTTTCTGCCTCTTCCGTG

GAACACACACATGGTGAACTCCTGGAAAAAACACTGTCTCAATATTATCC

AGATTGTGTTTCCATTGCGGTGCAGAAAACCACATCTCACATAAATGCCA

TTAACAGTCAGGCTACTAATGAGTTGTCCTGTGAGATCACTCACCCATCG

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatCATACCTCAGGGCAGATCAATTCCGCACAGACCTCTAACTCTGA

GCTGCCTCCAAAGCCAGCTGCAGTGGTGAGTGAGGCCTGTGATGCTGATG

ATGCTGATAATGCCAGTAAACTAGCTGCAATGCTAAATACCTGTTCCTTT

CAGAAACCAGAACAACTACAACAACAAAAATCAGTTTTTGAGATATGCCC

ATCTCCTGCAGAAAATAACATCCAGGGAACCACAAAGCTAGCGTCTGGTG

AAGAATTCTGTTCAGGTTCCAGCAGCAATTTGCAAGCTCCTGGTGGCAGC

TCTGAACGGTATTTAAAACAAAATGAAATGAATGGTGCTTACTTCAAGCA

AAGCTCAGTGTTCACTAAGGATTCCTTTTCTGCCACTACCACACCACCAC

CACCATCACAATTGCTTCTTTCTCCCCCTCCTCCTCTTCCACAGGTTCCT

CAGCTT

(SEQ ID NO: 187)

pARBI-968:
GGAAAAAGCACTCTGAATGGTGGAGTTTTAGAAGAACACCACCACTACCC
1806

TET2_3_
CAACCAAAGTAACACAACACTTTTAAGGGAAGTGAAAATAGAGGGTAAAC

Endogenous_75
CTGAGGCACCACCTTCCCAGAGTCCTAATCCATCTACACATGTATGCAGC

CCTTCTCCGATGCTTTCTGAAAGGCCTCAGAATAATTGTGTGAACAGGAA

TGACATACAGACTGCAGGGACAATGACTGTTCCATTGTGTTCTGAGAAAA

CAAGACCAATGTCAGAACACCTCAAGCATAACCCACCAATTTTTGGTAGC

AGTGGAGAGCTACAGGACAACTGCCAGCAGTTGATGAGAAACAAAGAGCA

AGAGATTCTGAAGGGTCGAGACAAGGAGCAAACACGAGATCTTGTGCCCC

CAACACAGCACTATCTGAAACCAGGATGGATTGAATTGAAGGCCCCTCGT

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatTTTCACCAAGCGGAATCCCATCTAAAACGTAATGAGGCATCACT

GCCATCAATTCTTCAGTATCAACCCAATCTCTCCAATCAAATGACCTCCA

AACAATACACTGGAAATTCCAACATGCCTGGGGGGCTCCCAAGGCAAGCT

TACACCCAGAAAACAACACAGCTGGAGCACAAGTCACAAATGTACCAAGT

TGAAATGAATCAAGGGCAGTCCCAAGGTACAGTGGACCAACATCTCCAGT

TCCAAAAACCCTCACACCAGGTGCACTTCTCCAAAACAGACCATTTACCA

AAAGCTCATGTGCAGTCACTGTGTGGCACTAGATTTCATTTTCAACAAAG

AGCAGATTCCCAAACTGAAAAACTTATGTCCCCAGTGTTGAAACAGCACT

TGAATCAACAGGCTTCAGAGACTGAGCCATTTTCAAACTCACACCTTTTG

CAACAT

(SEQ ID NO: 188)

pARBI-969:
AAAGGGAGGTTGAGATGGGCTGAGGTCTTCTAGGAGGCGGGGAGGGAGTG
1806

TIGIT_1_
CAGCCTTGACAAGCCTCCCTGTGGGCGAGGTGTAAAGAGGGGCAGAAGTC

Endogenous_76
AGCTCTGGAAGCATAGGGCAGTGGGTGGGGAGGAGATGGGCTGGGCTGGG

CTGGAGTAGAGATGTGTGGAGAAGGGTGAGAAGACTGGAAAGACAACCTG

AATGGGGGACTGGGAGCCTTGAATAACAGGCATGGAGAGGAGCGTCTCTT

GAAATGGAAGAAACAGGAAATAATTACAGCCTCTATGGAGGAGCAACAGG

ATGGACTGGAGAAACTATCATTCCAAAATCCAGTTGGGGCCTCAAAGGCC

CTTAGAATTTTTCTAGGAAGGTTGAAGGCCAGCTGCTGACCCAGGACTCA

CATGTGCTTCGTCCTCTTCCCTAGGAATGATGACAGGCACAATAGAAACA

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatACGGGGAACATTTCTGCAGAGAAAGGTGGCTCTATCATCTTACA

ATGTCACCTCTCCTCCACCACGGCACAAGTGACCCAGGTCAACTGGGAGC

AGCAGGACCAGCTTCTGGCCATTTGTAATGCTGACTTGGGGTGGCACATC

TCCCCATCCTTCAAGGATCGAGTGGCCCCAGGTCCCGGCCTGGGCCTCAC

CCTCCAGTCGCTGACCGTGAACGATACAGGGGAGTACTTCTGCATCTATC

ACACCTACCCTGATGGGACGTACACTGGGAGAATCTTCCTGGAGGTCCTA

GAAAGCTCAGGTATTCCTGCTGGAGCAAGTTGGTGGATAAACCTCTCCCT

CTAGCATAGAAAATGCAATCCTGAAACACTGCACAGCAGGGCTTCTCAAT

TCGGGATCACATTTGAATCACCTGAGGAGATTTTAAATCATACTGATGCC

GAGGCC

(SEQ ID NO: 189)

pARBI-970:
GAGGAGATGGGCTGGGCTGGGCTGGAGTAGAGATGTGTGGAGAAGGGTGA
1806

TIGIT_2_
GAAGACTGGAAAGACAACCTGAATGGGGGACTGGGAGCCTTGAATAACAG

Endogenous_77
GCATGGAGAGGAGCGTCTCTTGAAATGGAAGAAACAGGAAATAATTACAG

CCTCTATGGAGGAGCAACAGGATGGACTGGAGAAACTATCATTCCAAAAT

CCAGTTGGGGCCTCAAAGGCCCTTAGAATTTTTCTAGGAAGGTTGAAGGC

CAGCTGCTGACCCAGGACTCACATGTGCTTCGTCCTCTTCCCTAGGAATG

ATGACAGGCACAATAGAAACAACGGGGAACATTTCTGCAGAGAAAGGTGG

CTCTATCATCTTACAATGTCACCTCTCCTCCACCACGGCACAAGTGACCC

AGGTCAACTGGGAGCAGCAGGACCAGCTTCTGGCCATTTGTAATGCTGAC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatTTGGGGTGGCACATCTCCCCATCCTTCAAGGATCGAGTGGCCCC

AGGTCCCGGCCTGGGCCTCACCCTCCAGTCGCTGACCGTGAACGATACAG

GGGAGTACTTCTGCATCTATCACACCTACCCTGATGGGACGTACACTGGG

AGAATCTTCCTGGAGGTCCTAGAAAGCTCAGGTATTCCTGCTGGAGCAAG

TTGGTGGATAAACCTCTCCCTCTAGCATAGAAAATGCAATCCTGAAACAC

TGCACAGCAGGGCTTCTCAATTCGGGATCACATTTGAATCACCTGAGGAG

ATTTTAAATCATACTGATGCCGAGGCCTCACCCAGACCAATTCAATCAGA

ATCCCTAATAGCAGAGCTAAACAAGGGTAAGGTCTAAAAGCATTTCCAGG

TGATTCTAATGGGCAGCCAATACTGAGAACCACTGTTCTTATGTAAGAAG

CACATC

(SEQ ID NO: 190)

pARBI-971:
CCTCCCTGTGGGCGAGGTGTAAAGAGGGGCAGAAGTCAGCTCTGGAAGCA
1806

TIGIT_3_
TAGGGCAGTGGGTGGGGAGGAGATGGGCTGGGCTGGGCTGGAGTAGAGAT

Endogenous_78
GTGTGGAGAAGGGTGAGAAGACTGGAAAGACAACCTGAATGGGGGACTGG

GAGCCTTGAATAACAGGCATGGAGAGGAGCGTCTCTTGAAATGGAAGAAA

CAGGAAATAATTACAGCCTCTATGGAGGAGCAACAGGATGGACTGGAGAA

ACTATCATTCCAAAATCCAGTTGGGGCCTCAAAGGCCCTTAGAATTTTTC

TAGGAAGGTTGAAGGCCAGCTGCTGACCCAGGACTCACATGTGCTTCGTC

CTCTTCCCTAGGAATGATGACAGGCACAATAGAAACAACGGGGAACATTT

CTGCAGAGAAAGGTGGCTCTATCATCTTACAATGTCACCTCTCCTCCACC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatACGGCACAAGTGACCCAGGTCAACTGGGAGCAGCAGGACCAGCT

TCTGGCCATTTGTAATGCTGACTTGGGGTGGCACATCTCCCCATCCTTCA

AGGATCGAGTGGCCCCAGGTCCCGGCCTGGGCCTCACCCTCCAGTCGCTG

ACCGTGAACGATACAGGGGAGTACTTCTGCATCTATCACACCTACCCTGA

TGGGACGTACACTGGGAGAATCTTCCTGGAGGTCCTAGAAAGCTCAGGTA

TTCCTGCTGGAGCAAGTTGGTGGATAAACCTCTCCCTCTAGCATAGAAAA

TGCAATCCTGAAACACTGCACAGCAGGGCTTCTCAATTCGGGATCACATT

TGAATCACCTGAGGAGATTTTAAATCATACTGATGCCGAGGCCTCACCCA

GACCAATTCAATCAGAATCCCTAATAGCAGAGCTAAACAAGGGTAAGGTC

TAAAAG

(SEQ ID NO: 191)

pARBI-972:
TAATGCCCAGCCTAAGTTGGGGAGACCACTCCAGATTCCAAGATGTACAG
1806

TRAC_1_
TTTGCTTTGCTGGGCCTTTTTCCCATGCCTGCCTTTACTCTGCCAGAGTT

Endogenous_79
ATATTGCTGGGGTTTTGAAGAAGATCCTATTAAATAAAAGAATAAGCAGT

ATTATTAAGTAGCCCTGCATTTCAGGTTTCCTTGAGTGGCAGGCCAGGCC

TGGCCGTGAACGTTCACTGAAATCATGGCCTCTTGGCCAAGATTGATAGC

TTGTGCCTGTCCCTGAGTCCCAGTCCATCACGAGCAGCTGGTTTCTAAGA

TGCTATTTCCCGTATAAAGCATGAGACCGTGACTTGCCAGCCCCACAGAG

CCCCGCCCTTGTCCATCACTGGCATCTGGACTCCAGCCTGGGTTGGGGCA

AAGAGGGAAATGAGATCATGTCCTAACCCTGATCCTCTTGTCCCACAGAT

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatATCCAGAACCCTGACCCTGCCGTGTACCAGCTGAGAGACTCTAA

ATCCAGTGACAAGTCTGTCTGCCTATTCACCGATTTTGATTCTCAAACAA

ATGTGTCACAAAGTAAGGATTCTGATGTGTATATCACAGACAAAACTGTG

CTAGACATGAGGTCTATGGACTTCAAGAGCAACAGTGCTGTGGCCTGGAG

CAACAAATCTGACTTTGCATGTGCAAACGCCTTCAACAACAGCATTATTC

CAGAAGACACCTTCTTCCCCAGCCCAGGTAAGGGCAGCTTTGGTGCCTTC

GCAGGCTGTTTCCTTGCTTCAGGAATGGCCAGGTTCTGCCCAGAGCTCTG

GTCAATGATGTCTAAAACTCCTCTGATTGGTGGTCTCGGCCTTATCCATT

GCCACCAAAACCCTCTTTTTACTAAGAAACAGTGAGCCTTGTTCTGGCAG

TCCAGA

(SEQ ID NO: 192)

pARBI-973:
GATTCCAAGATGTACAGTTTGCTTTGCTGGGCCTTTTTCCCATGCCTGCC
1806

TRAC_2_
TTTACTCTGCCAGAGTTATATTGCTGGGGTTTTGAAGAAGATCCTATTAA

Endogenous_80
ATAAAAGAATAAGCAGTATTATTAAGTAGCCCTGCATTTCAGGTTTCCTT

GAGTGGCAGGCCAGGCCTGGCCGTGAACGTTCACTGAAATCATGGCCTCT

TGGCCAAGATTGATAGCTTGTGCCTGTCCCTGAGTCCCAGTCCATCACGA

GCAGCTGGTTTCTAAGATGCTATTTCCCGTATAAAGCATGAGACCGTGAC

TTGCCAGCCCCACAGAGCCCCGCCCTTGTCCATCACTGGCATCTGGACTC

CAGCCTGGGTTGGGGCAAAGAGGGAAATGAGATCATGTCCTAACCCTGAT

CCTCTTGTCCCACAGATATCCAGAACCCTGACCCTGCCGTGTACCAGCTG

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatAGAGACTCTAAATCCAGTGACAAGTCTGTCTGCCTATTCACCGA

TTTTGATTCTCAAACAAATGTGTCACAAAGTAAGGATTCTGATGTGTATA

TCACAGACAAAACTGTGCTAGACATGAGGTCTATGGACTTCAAGAGCAAC

AGTGCTGTGGCCTGGAGCAACAAATCTGACTTTGCATGTGCAAACGCCTT

CAACAACAGCATTATTCCAGAAGACACCTTCTTCCCCAGCCCAGGTAAGG

GCAGCTTTGGTGCCTTCGCAGGCTGTTTCCTTGCTTCAGGAATGGCCAGG

TTCTGCCCAGAGCTCTGGTCAATGATGTCTAAAACTCCTCTGATTGGTGG

TCTCGGCCTTATCCATTGCCACCAAAACCCTCTTTTTACTAAGAAACAGT

GAGCCTTGTTCTGGCAGTCCAGAGAATGACACGGGAAAAAAGCAGATGAA

GAGAAG

(SEQ ID NO: 193)

pARBI-974:
TTCCTGTGGTAGCGGAACTCACTAAGGGGCCCATCTGGACCCGAGGTATT
1806

TRAC_3_
GTGATGATAAATTCTGAGCACCTACCCCATCCCCAGAAGGGCTCAGAAAT

Endogenous_81
AAAATAAGAGCCAAGTCTAGTCGGTGTTTCCTGTCTTGAAACACAATACT

GTTGGCCCTGGAAGAATGCACAGAATCTGTTTGTAAGGGGATATGCACAG

AAGCTGCAAGGGACAGGAGGTGCAGGAGCTGCAGGCCTCCCCCACCCAGC

CTGCTCTGCCTTGGGGAAAACCGTGGGTGTGTCCTGCAGGCCATGCAGGC

CTGGGACATGCAAGCCCATAACCGCTGTGGCCTCTTGGTTTTACAGATAC

GAACCTAAACTTTCAAAACCTGTCAGTGATTGGGTTCCGAATCCTCCTCC

TGAAAGTGGCCGGGTTTAATCTGCTCATGACGCTGCGGCTGTGGTCCAGC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatTGAGGTGAGGGGCCTTGAAGCTGGGAGTGGGGTTTAGGGACGCG

GGTCTCTGGGTGCATCCTAAGCTCTGAGAGCAAACCTCCCTGCAGGGTCT

TGCTTTTAAGTCCAAAGCCTGAGCCCACCAAACTCTCCTACTTCTTCCTG

TTACAAATTCCTCTTGTGCAATAATAATGGCCTGAAACGCTGTAAAATAT

CCTCATTTCAGCCGCCTCAGTTGCACTTCTCCCCTATGAGGTAGGAAGAA

CAGTTGTTTAGAAACGAAGAAACTGAGGCCCCACAGCTAATGAGTGGAGG

AAGAGAGACACTTGTGTACACCACATGCCTTGTGTTGTACTTCTCTCACC

GTGTAACCTCCTCATGTCCTCTCTCCCCAGTACGGCTCTCTTAGCTCAGT

AGAAAGAAGACATTACACTCATATTACACCCCAATCCTGGCTAGAGTCTC

CGCACC

(SEQ ID NO: 194)

pARBI-975:
ATTATTAAGTAGCCCTGCATTTCAGGTTTCCTTGAGTGGCAGGCCAGGCC
1806

TRAC_4_
TGGCCGTGAACGTTCACTGAAATCATGGCCTCTTGGCCAAGATTGATAGC

Endogenous_82
TTGTGCCTGTCCCTGAGTCCCAGTCCATCACGAGCAGCTGGTTTCTAAGA

TGCTATTTCCCGTATAAAGCATGAGACCGTGACTTGCCAGCCCCACAGAG

CCCCGCCCTTGTCCATCACTGGCATCTGGACTCCAGCCTGGGTTGGGGCA

AAGAGGGAAATGAGATCATGTCCTAACCCTGATCCTCTTGTCCCACAGAT

ATCCAGAACCCTGACCCTGCCGTGTACCAGCTGAGAGACTCTAAATCCAG

TGACAAGTCTGTCTGCCTATTCACCGATTTTGATTCTCAAACAAATGTGT

CACAAAGTAAGGATTCTGATGTGTATATCACAGACAAAACTGTGCTAGAC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatATGAGGTCTATGGACTTCAAGAGCAACAGTGCTGTGGCCTGGAG

CAACAAATCTGACTTTGCATGTGCAAACGCCTTCAACAACAGCATTATTC

CAGAAGACACCTTCTTCCCCAGCCCAGGTAAGGGCAGCTTTGGTGCCTTC

GCAGGCTGTTTCCTTGCTTCAGGAATGGCCAGGTTCTGCCCAGAGCTCTG

GTCAATGATGTCTAAAACTCCTCTGATTGGTGGTCTCGGCCTTATCCATT

GCCACCAAAACCCTCTTTTTACTAAGAAACAGTGAGCCTTGTTCTGGCAG

TCCAGAGAATGACACGGGAAAAAAGCAGATGAAGAGAAGGTGGCAGGAGA

GGGCACGTGGCCCAGCCTCAGTCTCTCCAACTGAGTTCCTGCCTGCCTGC

CTTTGCTCAGACTGTTTGCCCCTTACTGCTCTTCTAGGCCTCATTCTAAG

CCCCTT

(SEQ ID NO: 195)

pARBI-976:
TTCATTTCCATTTGAGTTGTTCTTATTGAGTCATCCTTCCTGTGGTAGCG
1806

TRAC_6_
GAACTCACTAAGGGGCCCATCTGGACCCGAGGTATTGTGATGATAAATTC

Endogenous_84
TGAGCACCTACCCCATCCCCAGAAGGGCTCAGAAATAAAATAAGAGCCAA

GTCTAGTCGGTGTTTCCTGTCTTGAAACACAATACTGTTGGCCCTGGAAG

AATGCACAGAATCTGTTTGTAAGGGGATATGCACAGAAGCTGCAAGGGAC

AGGAGGTGCAGGAGCTGCAGGCCTCCCCCACCCAGCCTGCTCTGCCTTGG

GGAAAACCGTGGGTGTGTCCTGCAGGCCATGCAGGCCTGGGACATGCAAG

CCCATAACCGCTGTGGCCTCTTGGTTTTACAGATACGAACCTAAACTTTC

AAAACCTGTCAGTGATTGGGTTCCGAATCCTCCTCCTGAAAGTGGCCGGG

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatTTTAATCTGCTCATGACGCTGCGGCTGTGGTCCAGCTGAGGTGA

GGGGCCTTGAAGCTGGGAGTGGGGTTTAGGGACGCGGGTCTCTGGGTGCA

TCCTAAGCTCTGAGAGCAAACCTCCCTGCAGGGTCTTGCTTTTAAGTCCA

AAGCCTGAGCCCACCAAACTCTCCTACTTCTTCCTGTTACAAATTCCTCT

TGTGCAATAATAATGGCCTGAAACGCTGTAAAATATCCTCATTTCAGCCG

CCTCAGTTGCACTTCTCCCCTATGAGGTAGGAAGAACAGTTGTTTAGAAA

CGAAGAAACTGAGGCCCCACAGCTAATGAGTGGAGGAAGAGAGACACTTG

TGTACACCACATGCCTTGTGTTGTACTTCTCTCACCGTGTAACCTCCTCA

TGTCCTCTCTCCCCAGTACGGCTCTCTTAGCTCAGTAGAAAGAAGACATT

ACACTC

(SEQ ID NO: 196)

pARBI-977:
CAGTCCATCACGAGCAGCTGGTTTCTAAGATGCTATTTCCCGTATAAAGC
1806

TRAC_
ATGAGACCGTGACTTGCCAGCCCCACAGAGCCCCGCCCTTGTCCATCACT

Endogenous_83
GGCATCTGGACTCCAGCCTGGGTTGGGGCAAAGAGGGAAATGAGATCATG

TCCTAACCCTGATCCTCTTGTCCCACAGATATCCAGAACCCTGACCCTGC

CGTGTACCAGCTGAGAGACTCTAAATCCAGTGACAAGTCTGTCTGCCTAT

TCACCGATTTTGATTCTCAAACAAATGTGTCACAAAGTAAGGATTCTGAT

GTGTATATCACAGACAAAACTGTGCTAGACATGAGGTCTATGGACTTCAA

GAGCAACAGTGCTGTGGCCTGGAGCAACAAATCTGACTTTGCATGTGCAA

ACGCCTTCAACAACAGCATTATTCCAGAAGACACCTTCTTCCCCAGCCCA

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatGGTAAGGGCAGCTTTGGTGCCTTCGCAGGCTGTTTCCTTGCTTC

AGGAATGGCCAGGTTCTGCCCAGAGCTCTGGTCAATGATGTCTAAAACTC

CTCTGATTGGTGGTCTCGGCCTTATCCATTGCCACCAAAACCCTCTTTTT

ACTAAGAAACAGTGAGCCTTGTTCTGGCAGTCCAGAGAATGACACGGGAA

AAAAGCAGATGAAGAGAAGGTGGCAGGAGAGGGCACGTGGCCCAGCCTCA

GTCTCTCCAACTGAGTTCCTGCCTGCCTGCCTTTGCTCAGACTGTTTGCC

CCTTACTGCTCTTCTAGGCCTCATTCTAAGCCCCTTCTCCAAGTTGCCTC

TCCTTATTTCTCCCTGTCTGCCAAAAAATCTTTCCCAGCTCACTAAGTCA

GTCTCACGCAGTCACTCATTAACCCACCAATCACTGATTGTGCCGGCACA

TGAATG

(SEQ ID NO: 197)

pARBI-978:
TGAGGAAGAAGCGCGGGCGGCGCCTTCGGGAGGCGAGCAGGCAGCAGTTG
1806

TRIM28_1_
GCCGTGCCGTAGCAGCGTCCCGCGCGCGGCGGGCAGCGGCCCAGGAGGCG

Endogenous_85
CGTGGCGGCGCTCGGCCTCGCGGCGGCGGCGGCGGCAGCGGCCCAGCAGT

TGGCGGCGAGCGCGTCTGCGCCTGCGCGGCGGGCCCCGCGCCCCTCCTCC

CCCCCTGGGCGCCCCCGGCGGCGTGTGAATGGCGGCCTCCGCGGCGGCAG

CCTCGGCAGCAGCGGCCTCGGCCGCCTCTGGCAGCCCGGGCCCGGGCGAG

GGCTCCGCTGGCGGCGAAAAGCGCTCCACCGCCCCTTCGGCCGCAGCCTC

GGCCTCTGCCTCAGCCGCGGCGTCGTCGCCCGCGGGGGGCGGCGCCGAGG

CGCTGGAGCTGCTGGAGCACTGCGGCGTGTGCAGAGAGCGCCTGCGACCC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatGAGAGGGAGCCCCGCCTGCTGCCCTGTTTGCACTCGGCCTGTAG

TGCCTGCTTAGGGCCCGCGGCCCCCGCCGCCGCCAACAGCTCGGGGGACG

GCGGGGCGGCGGGCGACGGCACCGGTAAGTACGAAGTGATCGGTGCCACC

CCTCCCCCTACTCTCTGCCTTTGATTCCGACTGGGTGCAGAGATGAGGAT

GCCACCTGGGCGAGAGGATGGGGGCCCGGACAGGGCACGGGAAATACTTT

CTGGGTCCTGCATACGAACGTGGGTTTGTGCTGGCCGCTGAGATGGGACA

TCTGACTAAAGTTGGAGAAAAGAAGGCTCGGGGAGGGGAGGGGCTGGTTC

GCTGCGGGATAATGGTCGGGGGCCCACCCAGCAGGGGAATGGTGGGGGCC

ATAACCTGGGTGGGAACTTGTAACAGTCTCCCACATCCCTGCTTCTCGAA

GTGGTG

(SEQ ID NO: 198)

pARBI-979:
TCGAAGTGGTGGACTGTCCCGTGTGCAAGCAACAGTGCTTCTCCAAAGAC
1806

TRIM28_2_
ATCGTGGAGAATTATTTCATGCGTGATAGTGGCAGCAAGGCTGCCACCGA

Endogenous_86
CGCCCAGGATGCGAACCAGGTGCGTCCTATCTCAGCAACCACAAGGAGGT

TTCTGGGGAGGGGGCATCTGCGCAGGAGGAGCTTGGCACCAGCTCCAGGC

TGTTACTCCACTTTCCCAAGGCTCTGGGTGGGCTGCCTAGGTTGGGTCAA

GGGACCAATCTTAAATCTCCGGTTGTATTTTCTGGGATGTAAACGTGGAT

CTATCAAGTIGTCTTGCCTTCTCTGACCCTGCCTTTGTCTGGCAGTGCTG

CACTAGCTGTGAGGATAATGCCCCAGCCACCAGCTACTGTGTGGAGTGCT

CGGAGCCTCTGTGTGAGACCTGTGTAGAGGCGCACCAGCGGGTGAAGTAC

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatACCAAGGACCATACTGTGCGCTCTACTGGTACATGAGGCTGAGG

GGGGCTGTTGGAGTTGTTCTCCCATGTGTGCCCTCAGTTGCTTTTATGAT

GTTGGTTGCATCTGGTGGATGGGTCCTAGAGTTCTCTAGGGGGTGCCGCC

CGAAGGGCCCGAGGGCAGAACTCCAGAAGCAGAAAAACTGGGGTTGTGGT

GTGTAGTCTCTAGGGCCTAGGTGGGAGAGGGTGGGAAGGGGAAATAAGGG

AGACCTTAATGTGCTGCAGGGAGGTACAAAGGGTTTGAGAAGGCTTATCA

GGGAGTTGTCAGACCTGGTGGTGAAGGGCTCAGCATATGCAAACAGGGAA

AGGCATGGTGTGAAGGGCTTTCTGGGTTTGTGGTTCCCTGGCACACATCT

GGTATAAGATGCTGCTAGGGAAAGTAGACTGTGGGTCCATGGATTATAAG

TGATGA

(SEQ ID NO: 199)

pARBI-980:
GGCGCCCAATGCGCGTGCGCGGCGGCGTCGGCGCCAGTTATTTCTGTCCC
1806

TRIM28_3_
GCCCCCCGGCCTCGGCTCTTTCTGCGAGCGGGCGCGCGGGCGAGCGGTTG

EndogenouS_87
TGCTTGTGCTTGTGGCGCGTGGTGCGGGTTTCGGCGGCGGCTGAGGAAGA

AGCGCGGGCGGCGCCTTCGGGAGGCGAGCAGGCAGCAGTTGGCCGTGCCG

TAGCAGCGTCCCGCGCGCGGCGGGCAGCGGCCCAGGAGGCGCGTGGCGGC

GCTCGGCCTCGCGGCGGCGGCGGCGGCAGCGGCCCAGCAGTTGGCGGCGA

GCGCGTCTGCGCCTGCGCGGCGGGCCCCGCGCCCCTCCTCCCCCCCTGGG

CGCCCCCGGCGGCGTGTGAATGGCGGCCTCCGCGGCGGCAGCCTCGGCAG

CAGCGGCCTCGGCCGCCTCTGGCAGCCCGGGCCCGGGCGAGGGCTCCGCT

tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga

ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG

TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC

AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT

GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG

TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatGGCGGCGAAAAGCGCTCCACCGCCCCTTCGGCCGCAGCCTCGGC

CTCTGCCTCAGCCGCGGCGTCGTCGCCCGCGGGGGGCGGCGCCGAGGCGC

TGGAGCTGCTGGAGCACTGCGGCGTGTGCAGAGAGCGCCTGCGACCCGAG

AGGGAGCCCCGCCTGCTGCCCTGTTTGCACTCGGCCTGTAGTGCCTGCTT

AGGGCCCGCGGCCCCCGCCGCCGCCAACAGCTCGGGGGACGGCGGGGCGG

CGGGCGACGGCACCGGTAAGTACGAAGTGATCGGTGCCACCCCTCCCCCT

ACTCTCTGCCTTTGATTCCGACTGGGTGCAGAGATGAGGATGCCACCTGG

GCGAGAGGATGGGGGCCCGGACAGGGCACGGGAAATACTTTCTGGGTCCT

GCATACGAACGTGGGTTTGTGCTGGCCGCTGAGATGGGACATCTGACTAA

AGTTGG

(SEQ ID NO: 200)

pARBI-596:
ATCTCGGCCAATAAAGGAGAAAGGGCGCGGCCCGTACGCGCGCCAGGTGC
2541

APRT_1_
GTGGGCGAGACCAGCTCACGCCCCTCCTCCAGCCGCCAAGGCCCCGGCCC

Exogenous_1
ACAGCTGCCTGGCTGCAGTCAGAAGCGTAGCCCGAGACAAGGAAGGGCGC

CTTGACTCGCACTTTTGTCCGGTTCGAACGTTCTGctcagtggtgcgtgg

aatgcgagcgcgtcttaaaatcgatggcgcctaggagtccatgaaatacg

gTACAGGCTTCCGGCGACGGATGCCCCGCCCCTCACCCACGCTCCGCCCT

CCGGGGATGCCCCACCCCTCGTGGCGGTCCCGCCCGTCCCCGCGCAGGCG

CGCTCGGGCTGCCGCTGGCTCTTCGCACGCGGCCATGGCCGACTCCGAGC

TGCAGCTGGTTGAGCAGCGGATCCGCAGCTTCCCCGACTTCCCCACCCCA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatGGCGTGGTAT

TCAGGTGCACGCACAGGCCGCCCTCGTGGCGCCCCGACCTGCGGGCCTAC

GGATGGGAGCGCGTGGCCCGCGACCTCCGGGGGGCGGGGCGGGAACCCTC

GTCTTTCGCCCCCGGGGCCCTGCCCTCCTTCGGCCCCGGCGTCACCAGGC

CTGTCCTTGGGTCCAGGGACATCTCGCCCGTCCTGAAGGACCCCGCCTCC

TTCCGCGCCGCCATCGGCCTCCTGGCGCGACACCTGAAGGCGACCCACGG

GGGCCGCATCGACTACATCGCAGGCGAGTGCCCAGTGGCCGCATCTAGGG

CGCTTCCGCCTCTGCGCGCGCCGAGGGCAGCACGTGGGCTCTGCGCGTCT

GCTTGGGGGAGGGCCTTTGGGGTGCTTCAGGGGGCGCCGGGACGGGCGCC

GTGCTTGGGTCGCCCGGGAAGGGTTGTGAGATTGAGCCC

(SEQ ID NO: 201)

pARBI-597:
TGCCCCGCCCCTCACCCACGCTCCGCCCTCCGGGGATGCCCCACCCCTCG
2541

APRT_2_
TGGCGGTCCCGCCCGTCCCCGCGCAGGCGCGCTCGGGCTGCCGCTGGCTC

Exogenous_2
TTCGCACGCGGCCATGGCCGACTCCGAGCTGCAGCTGGTTGAGCAGCGGA

TCCGCAGCTTCCCCGACTTCCCCACCCCAGGCGTGGTATTCAGGTGCACG

CACAGGCCGCCCTCGTGGCGCCCCGACCTGCGGGCCTACGGATGGGAGCG

CGTGGCCCGCGACCTCCGGGGGGGGGGGGCGGGAACCCTCGTCTTTCGCC

CCCGGGGCCCTGCCCTCCTTCGGCCCCGGCGTCACCAGGCCTGTCCTTGG

GTCCAGGGACATCTCGCCCGTCCTGAAGGACCCCGCCTCCTTCCGCGCCG

CCATCGGCCTCCTGGCGCGACACCTGAAGGCGACCCACGGGGGCCGCATC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatGACTACATC

GCAGGCGAGTGCCCAGTGGCCGCATCTAGGGCGCTTCCGCCTCTGCGCGC

GCCGAGGGCAGCACGTGGGCTCTGCGCGTCTGCTTGGGGGAGGGCCTTTG

GGGTGCTTCAGGGGGCGCCGGGACGGGCGCCGTGCTTGGGTCGCCCGGGA

AGGGTTGTGAGATTGAGCCCCCGAGGCCGCCGCGCTGTGCAGGCGTCCTT

CCCGCAGGTTCCGGGTCCCCAGCCCAGGACAGGCGTGACCGAGTTGCCGG

GTCAGTTGGTCTCCCTGGAGTGCCCAAGCTGAATCCACAGGGCCCAGCTG

CCTTGCTTCTTGTTCCTTCTGCGAGCTGGTATTGAGCGCCTGCCACGAGC

CAGGCCTTCCCTGGTGAAGATCACGGAATGCCCACCCAGGGAAGGGAGGC

CTGGAGGCCTCCGGGAGAGCCCAAGAGGTGGCCCAGGGAGA

(SEQ ID NO: 202)

pARBI-598:
CGTTCTGctcagtggtgcgtggaatgcgagcgcgtcttaaaatcgatggc
2541

APRT_3_
gcctaggagtccatgaaatacggTACAGGCTTCCGGCGACGGATGCCCCG

Exogenous_3
CCCCTCACCCACGCTCCGCCCTCCGGGGATGCCCCACCCCTCGTGGCGGT

CCCGCCCGTCCCCGCGCAGGCGCGCTCGGGCTGCCGCTGGCTCTTCGCAC

GCGGCCATGGCCGACTCCGAGCTGCAGCTGGTTGAGCAGCGGATCCGCAG

CTTCCCCGACTTCCCCACCCCAGGCGTGGTATTCAGGTGCACGCACAGGC

CGCCCTCGTGGCGCCCCGACCTGCGGGCCTACGGATGGGAGCGCGTGGCC

CGCGACCTCCGGGCGGGCGGGGGGGGAACCCTCGTCTTTCGCCCCCGGGG

CCCTGCCCTCCTTCGGCCCCGGCGTCACCAGGCCTGTCCTTGGGTCCAGG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatGACATCTCGC

CCGTCCTGAAGGACCCCGCCTCCTTCCGCGCCGCCATCGGCCTCCTGGCG

CGACACCTGAAGGCGACCCACGGGGGCCGCATCGACTACATCGCAGGCGA

GTGCCCAGTGGCCGCATCTAGGGCGCTTCCGCCTCTGCGCGCGCCGAGGG

CAGCACGTGGGCTCTGCGCGTCTGCTTGGGGGAGGGCCTTTGGGGTGCTT

CAGGGGGCGCCGGGACGGGCGCCGTGCTTGGGTCGCCCGGGAAGGGTTGT

GAGATTGAGCCCCCGAGGCCGCCGCGCTGTGCAGGCGTCCTTCCCGCAGG

TTCCGGGTCCCCAGCCCAGGACAGGCGTGACCGAGTTGCCGGGTCAGTTG

GTCTCCCTGGAGTGCCCAAGCTGAATCCACAGGGCCCAGCTGCCTTGCTT

CTTGTTCCTTCTGCGAGCTGGTATTGAGCGCCTGCCACGA

(SEQ ID NO: 203)

pARBI-599:
AGTAATTTGATGGGGGCTATTATGAACTGAGAAATGAACTTTGAAAAGTA
2541

B2M_1_
TCTTGGGGCCAAATCATGTAGACTCTTGAGTGATGTGTTAAGGAATGCTA

Exogenous_4
TGAGTGCTGAGAGGGCATCAGAAGTCCTTGAGAGCCTCCAGAGAAAGGCT

CTTAAAAATGCAGCGCAATCTCCAGTGACAGAAGATACTGCTAGAAATCT

GCTAGAAAAAAAACAAAAAAGGCATGTATAGAGGAATTATGAGGGAAAGA

TACCAAGTCACGGTTTATTCTTCAAAATGGAGGTGGCTTGTTGGGAAGGT

GGAAGCTCATTTGGCCAGAGTGGAAATGGAATTGGGAGAAATCGATGACC

AAATGTAAACACTTGGTGCCTGATATAGCTTGACACCAAGTTAGCCCCAA

GTGAAATACCCTGGCAATATTAATGTGTCTTTTCCCGATATTCCTCAGGT

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatACTCCAAAG

ATTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAGTCAAATTTCCT

GAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTTAC

TGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTC

AGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGAATTCACCCCCAC

TGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGC

CCAAGATAGTTAAGTGGGGTAAGTCTTACATTCTTTTGTAAGCTGCTGAA

AGTTGTGTATGAGTAGTCATATCATAAAGCTGCTTTGATATAAAAAAGGT

CTATGGCCATACTACCCTGAATGAGTCCCATCCCATCTGATATAAACAAT

CTGCATATTGGGATTGTCAGGGAATGTTCTTAAAGATCAGA

(SEQ ID NO: 204)

pARBI-600:
AAGATCTTAATCTTCTGGGTTTCCGTTTTCTCGAATGAAAAATGCAGGTC
2541

B2M_2_
CGAGCAGTTAACTGGCTGGGGCACCATTAGCAAGTCACTTAGCATCTCTG

Exogenous_5
GGGCCAGTCTGCAAAGCGAGGGGGCAGCCTTAATGTGCCTCCAGCCTGAA

GTCCTAGAATGAGCGCCCGGTGTCCCAAGCTGGGGCGCGCACCCCAGATC

GGAGGGCGCCGATGTACAGACAGCAAACTCACCCAGTCTAGTGCATGCCT

TCTTAAACATCACGAGACTCTAAGAAAAGGAAACTGAAAACGGGAAAGTC

CCTCTCTCTAACCTGGCACTGCGTCGCTGGCTTGGAGACAGGTGACGGTC

CCTGCGGGCCTTGTCCTGATTGGCTGGGCACGCGTTTAATATAAGTGGAG

GCGTCGCGCTGGCGGGCATTCCTGAAGCTGACAGCATTCGGGCCGAGATG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatTCTCGCTCCG

TGGCCTTAGCTGTGCTCGCGCTACTCTCTCTTTCTGGCCTGGAGGCTATC

CAGCGTGAGTCTCTCCTACCCTCCCGCTCTGGTCCTTCCTCTCCCGCTCT

GCACCCTCTGTGGCCCTCGCTGTGCTCTCTCGCTCCGTGACTTCCCTTCT

CCAAGTTCTCCTTGGTGGCCCGCCGTGGGGCTAGTCCAGGGCTGGATCTC

GGGGAAGCGGCGGGGTGGCCTGGGAGTGGGGAAGGGGGTGCGCACCCGGG

ACGCGCGCTACTTGCCCCTTTCGGCGGGGAGCAGGGGAGACCTTTGGCCT

ACGGCGACGGGAGGGTCGGGACAAAGTTTAGGGCGTCGATAAGCGTCAGA

GCGCCGAGGTTGGGGGAGGGTTTCTCTTCCGCTCTTTCGCGGGGCCTCTG

GCTCCCCCAGCGCAGCTGGAGTGGGGGACGGGTAGGCTCG

(SEQ ID NO: 205)

pARBI-601:
AGGAATGCTATGAGTGCTGAGAGGGCATCAGAAGTCCTTGAGAGCCTCCA
2541

B2M_3_
GAGAAAGGCTCTTAAAAATGCAGCGCAATCTCCAGTGACAGAAGATACTG

Exogenous_6
CTAGAAATCTGCTAGAAAAAAAACAAAAAAGGCATGTATAGAGGAATTAT

GAGGGAAAGATACCAAGTCACGGTTTATTCTTCAAAATGGAGGTGGCTTG

TTGGGAAGGTGGAAGCTCATTTGGCCAGAGTGGAAATGGAATTGGGAGAA

ATCGATGACCAAATGTAAACACTTGGTGCCTGATATAGCTTGACACCAAG

TTAGCCCCAAGTGAAATACCCTGGCAATATTAATGTGTCTTTTCCCGATA

TTCCTCAGGTACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGA

ATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatGACATTGAA

GTTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGA

CTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGAAT

TCACCCCCACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACT

TTGTCACAGCCCAAGATAGTTAAGTGGGGTAAGTCTTACATTCTTTTGTA

AGCTGCTGAAAGTTGTGTATGAGTAGTCATATCATAAAGCTGCTTTGATA

TAAAAAAGGTCTATGGCCATACTACCCTGAATGAGTCCCATCCCATCTGA

TATAAACAATCTGCATATTGGGATTGTCAGGGAATGTTCTTAAAGATCAG

ATTAGTGGCACCTGCTGAGATACTGATGCACAGCATGGTTTCTGAACCAG

TAGTTTCCCTGCAGTTGAGCAGGGAGCAGCAGCAGCACTTG

(SEQ ID NO: 206)

pARBI-602:
GATCTCACATTCTAGCGCCCAGACATGTCGGGAACGCCTTACGCCAACTT
2541

CAPNS1_1_
GGGGTCCCCACCAAGAGAACCCCCACCAGATCTGCACCCTCCCCTTCACG

Exogenous_7
CGTGCACCCAGTCCAGGCTCCCTCAAGCCCCACGGGTGCCTTTTAGACCT

GAGGAGGTTGCAAACCTGATCCCCCATACCTGCCCCACCCATCCGCGGAC

AACCCGCCCTCGCAAACTCAGACCCCCACCCGGAGGCTTCAGATTCCTCC

CAGGTCCAGCTGCCGGAAATGCGTGTTTGAAGGGAGGGTGTGGGCTCAGG

GGCGAAGCACCCACTGGTCCCCTTTTTTCCCCCCAGCAGTGAGTCGCAGC

CATGTTCCTGGTTAACTCGTTCTTGAAGGGCGGCGGCGGCGGCGGCGGGG

GAGGCGGGGGCCTGGGTGGGGGCCTGGGAAATGTGCTTGGAGGCCTGATC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatAGCGGGGCC

GGGGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGTGGTGGAGGCGGCGG

TGGCGGTGGAACGGCCATGCGCATCCTAGGCGGAGTCATCAGCGCCATCA

GGTAAGGCGGAGACTATCAGAGGGGCGGGGCCTGGGAATGGGAGGAGCCT

CAGTGAGGCGTGGTCTGGGAGGGGCGTGGTCTAAAAATAGAATAGGATTA

ACCTGGAGGCTAACCTGGGTACATGAATTAGGCCGGGGAGGCCTGGTTTG

AGAGTTCTGCTGTAAGGGGGTGGACCCCAGTGAGGCGGATATCAGTCATT

GGGGGCGGTGCTTGATATGGGAGTAGTCTGATTGTGTGGGACCAGGACAA

TGTGGTCCTGAGGGGACTGATGTGGAGTTTTGGCGGGTGGGGCTTATGGG

TCTGGGCTCAGCCTGCATTGGCTAACCTGGAGATGAACGTT

(SEQ ID NO: 207)

pARBI-603:
CGGGCATTTAGGAAGCGGGCCATGGAGTAGGGTCTTGGGCAGATGGCACC
2541

CAPNS1_2_
TGAGGAGGATAAGGCCTTGGGAAGCTGGGGCAGAGCCTCTATGAAGTGAG

Exogenous_8
CCCTCCAAGGGGCGGGGTCTTTTGATTCTACGTGGGATTTTTTAGGTTTA

GGGTGGCCAAGATGACTGAAATCTGCCACTGGGTAGGTGTGCCTGGCAGG

AGGGGAGCCTCCCAGGGGACCGGTCTCTGGGTTTCCTCGAGGGTGGGGTT

GGCCTGAGGAAGGGAGAAGAGGGGCACGACCAGGGCAGTGTGGATTGGGA

CAGATGAGGACAAGAACAAATGAAAGGCACAGCAACCAAGTAAGGAAGAT

AACGGCTGGGGTCTGGAGCGTTGGGGCTGATGGTTCTGTAGTGCTGCCCG

TTGGAGGCCCCGCCCCTGGCACTAACCCCTCCCCCTTATCTCTTCGCAGC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACAT

CGCCCACAGTCCCCGAGAAGTTGGGGGGAGGGGTCGGCAATTGAACGGGT

GCCTAGAGAAGGTGGCGCGGGGTAAACTGGGAAAGTGATGTCGTGTACTG

GCTCCGCCTTTTTCCCGAGGGTGGGGGAGAACCGTATATAAGTGCAGTAG

TCGCCGTGAACGTTCTTTTTCGCAACGGGTTTGCCGCCAGAACACAGCTG

AAGCTTCGAGGGGCTCGCATCTCTCCTTCACGCGCCCGCCGCCCTACCTG

AGGCCGCCATCCACGCCGGTTGAGTCGCGTTCTGCCGCCTCCCGCCTGTG

GTGCCTCCTGAACTGCGTCCGCCGTCTAGGTAAGTTTAAAGCTCAGGTCG

AGACCGGGCCTTTGTCCGGCGCTCCCTTGGAGCCTACCTAGACTCAGCCG

GCTCTCCACGCTTTGCCTGACCCTGCTTGCTCAACTCTACGTCTTTGTTT

CGTTTTCTGTTCTGCGCCGTTACAGATCCAAGCTGTGACCGGCGCCTACT

CTAGAGCTAGCGAATTgccgccaccATGGTGAGCAAGGGCGAGGAGCTGT

TCACCGGGGTGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGC

CACAAGTTCAGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAA

GCTGACCCTGAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGC

CCACCCTCGTGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTAC

CCCGACCACATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGG

CTACGTCCAGGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGA

CCCGCGCCGAGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAG

CTGAAGGGCATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCT

GGAGTACAACTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGA

AGAACGGCATCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGC

AGCGTGCAGCTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGG

CCCCGTGCTGCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGA

GCAAAGACCCCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTG

ACCGCCGCCGGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtt

tattgcagcttataatggttacaaataaagcaatagcatcacaaatttca

caaataaagcatttttttcactgcattctagttgtggtttgtccaaactc

atcaatgtatcttatGAGGCGGCTGCGCAGTACAACCCGGAGCCCCCGGT

AAGCCCCCTCTGCAACCAGACCCCCTTCTCCTGCCAAGGCCTCTTCGAGG

TCCCATCCCTGTTCCTGTAGAGAAGCCCCACCTTCCTCCCCTTCTTGTGA

AATTCCTCTGCCAGTTCCTCCCATGCCGTGTCTGCAGCTTCGCCATGGGT

CTTAGCCATGCCCCACATACGTGCACCCCATTCACTACCACCCCTCATTC

TTTTCCTCATCAAGCTGCCCAGCCCACTCTGACTTCCCCACCCAGGGTAC

CTGGGTTTGGGGAGCCGTCCTGGCCGGGTTCCCCTCCCCCTGCTCTGAGC

TCTCCTCCCTTTGCAGCCCCCACGCACACATTACTCCAACATTGAGGCCA

ACGAGAGTGAGGAGGTCCGGCAGTTCCGGAGACTCTTTGCCCAGCTGGCT

GGAGATGTAAGTAAC

(SEQ ID NO: 208)

pARBI-604:
GCTGATGGTTCTGTAGTGCTGCCCGTTGGAGGCCCCGCCCCTGGCACTAA
2541

CAPNS1_3_
CCCCTCCCCCTTATCTCTTCGCAGCGAGGCGGCTGCGCAGTACAACCCGG

Exogenous_9
AGCCCCCGGTAAGCCCCCTCTGCAACCAGACCCCCTTCTCCTGCCAAGGC

CTCTTCGAGGTCCCATCCCTGTTCCTGTAGAGAAGCCCCACCTTCCTCCC

CTTCTTGTGAAATTCCTCTGCCAGTTCCTCCCATGCCGTGTCTGCAGCTT

CGCCATGGGTCTTAGCCATGCCCCACATACGTGCACCCCATTCACTACCA

CCCCTCATTCTTTTCCTCATCAAGCTGCCCAGCCCACTCTGACTTCCCCA

CCCAGGGTACCTGGGTTTGGGGAGCCGTCCTGGCCGGGTTCCCCTCCCCC

TGCTCTGAGCTCTCCTCCCTTTGCAGCCCCCACGCACACATTACTCCAAC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCC

GCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGTCGCGTTCTGCCGCCT

CCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGTCTAGGTAAGTTTAAA

GCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCCCTTGGAGCCTACCTA

GACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTGCTTGCTCAACTCTAC

GTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAGATCCAAGCTGTGACC

GGCGCCTACTCTAGAGCTAGCGAATTgccgccaccATGGTGAGCAAGGGC

GAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGTCGAGCTGGACGGCGA

CGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGGGCGAGGGCGATGCCA

CCTACGGCAAGCTGACCCTGAAGTTCATCTGCACCACCGGCAAGCTGCCC

GTGCCCTGGCCCACCCTCGTGACCACCCTGACCTACGGCGTGCAGTGCTT

CAGCCGCTACCCCGACCACATGAAGCAGCACGACTTCTTCAAGTCCGCCA

TGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTCTTCAAGGACGACGGC

AACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGGCGACACCCTGGTGAA

CCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGGACGGCAACATCCTGG

GGCACAAGCTGGAGTACAACTACAACAGCCACAACGTCTATATCATGGCC

GACAAGCAGAAGAACGGCATCAAGGTGAACTTCAAGATCCGCCACAACAT

CGAGGACGGCAGCGTGCAGCTCGCCGACCACTACCAGCAGAACACCCCCA

TCGGCGACGGCCCCGTGCTGCTGCCCGACAACCACTACCTGAGCACCCAG

TCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGATCACATGGTCCTGCT

GGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCATGGACGAGCTGTACA

Aatgattgtttattgcagcttataatggttacaaataaagcaatagcatc

acaaatttcacaaataaagcatttttttcactgcattctagttgtggttt

gtccaaactcatcaatgtatcttatATTGAGGCCAACGAGAGTGAGGAGG

TCCGGCAGTTCCGGAGACTCTTTGCCCAGCTGGCTGGAGATGTAAGTAAC

CTGGGGTCCCTGGCCCCGTCCTAACCGTTCCATCCCTTCCCTTGTGGCTG

CCCTTGCACACACACCCTTGACCATGACAATCCCAGTGTTCCCATTCTCC

ATGACATTCTCAGACCCCTTTCAGTCACCCCTGACCTGCCCCTAACTTCC

GCCCGCAGGACATGGAGGTCAGCGCCACAGAACTCATGAACATTCTCAAT

AAGGTTGTGACACGACGTAAGTGACCGGGGTTAAGGAATAGGGTAGATTC

AGAGGCAGAGGGGTCAGAGAGGATTTGACCTCTGGCCTCTGACTTTCAAC

CTGTTACCCACAGACCCTGATCTGAAGACTGATGGTTTTGGCATTGACAC

ATGTCGCAGCATGGTGGCCGTGATG

(SEQ ID NO: 209)

pARBI-605:
ggagagttatagcagatggagacaaaaaagggaactgctggggatcaaac
2541

CBLB_1_
cttgtaaagtccttctaagtgatatatgaggactttgacttttattcaaa

Exogenous_10
gttagaaggctttgaacaaaagaattatttcatttgtgttttacaatggt

cacaagtgccgtagcgagaataggctgTGTAGAGAAGAGATTTTGTGGTT

TTCTTTTTTGTTCTCTGTATTCTCTTCCTGAAAAATCTGTTTTCTGCCTA

ATCATATTTCTGTAAAGAACAATAGACTTGAACGTCTGCTGTTAAGTAAC

AAAGGTTGACCTAAACCACATAAGGTCAGATTAACTTTTAAAATATCCAA

GATAATGTTAAGTGTATTAAATATGGTTCAGTATGTAATCAAAATATTTG

ATATTCTCTAGATACTAATCTCttttaatttttttattttttAGCCTTGG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatGGCTCTATT

TTGCGGAATTGGAATTTCTTAGCTGTGACACATCCAGGTTACATGGCATT

TCTCACATATGATGAAGTTAAAGCACGACTACAGAAATATAGCACCAAAC

CCGGAAGGTAAGACTTTTTAGCAGTAATATTATGTGATATATCCAAAGAT

GAAAAATTCTCCATGGTTTGTTCCTAAGTAAGTCAGCAATACCCGCTGAT

GGCATGCTTGGGAGGGGGCTAGAAAAGGTAAAAGACCAAAATGGTGCTTC

TTAACATAATGTTTTAAATTGATACATTGTGCTTACTCTGAAACTTGGTA

TTCATAAAGTGAAAGGGGATATGGTCTCCTTTCTGTTTTCATGATATCCG

TGTTTATGTGCAAAATTGAATGTATATATTTGAATACTTGAATACTGTGC

TAAAGAACAAATAAATAGAACAGTCTTATGTTCATTACTTT

(SEQ ID NO: 210)

pARBI-606:
CATATTACTCATTTGTGCAATGAATAAAGGATTTCTATTATTATATGGAC
2541

CBLB_2_
CCATCATCTTATGACTGTTTTTAGAAAATGAGAATTAAATCTTGATTCAT

Exogenous_11
TATTAAATAACCTTGTATACACACATGAAGAGGTCATGACACATAAGACT

TTGACCTAATACCTTTTTTCAGATATGTTTCTATAGCTATCTTGATAGCC

TAGGACTGTTTGAGAGAAAATTAATTTAAATTTTTGTCATATTCTTAGCA

AATGCAAAATAATTGAGTTAAACAGAACCCACTACATTTGTTCTGAAATA

TGAACAATATTCTCAAATATTTGTCTGGTAGTACAAATACAATTATATTA

ATTTTATTATTGAATTTTGCTGCTTCAAAGGGAGGTATTTCTTAAATGAT

ACTTGATTCAATTATTTCCCTTTTTTTCCACCTTGCACAGAACTATCGTA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC

ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA

GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG

AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC

ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA

CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA

TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG

CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT

GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC

CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC

GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc

ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag

catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta

tcttatCCATGGAAAGTATTCAGACAGTGCCTTCATGAGGTCCACCAGAT

TAGCTCTGGCCTGGAAGCAATGGCTCTAAAATCAACAATTGATTTAACTT

GCAATGATTACATTTCAGTTTTTGAATTTGATATTTTTACCAGGCTGTTT

CAGGTAAGTTTATACTTGCTTAGTCTATCCATTCCCTtcttctctctccc

tgtcttttctctctgtttctctctctctctgtctctctctcacacacaca

cacaTAAACAAACATATGGAAAATAGTGTCATTCCTATTAGTCTGTAATT

TTATTGGTATGTTTGGTCATTGTTAAAAGTTTAGAGTGAGCCATTTGGCT

TAAGTTTGGAGTTATCAGATGCTGTGAGCCTGGTGGCTGCTTGTTAGCTT

TGAGAGGATCCATCCAAAAGAGCTTTGTTTTAAACTCTCTACTTAGTTTC

TTACTT

(SEQ ID NO: 211)

pARBI-607:
TTAAACTTTAGAGGTTCAAAATAAGGATATGATATAGAAAAGATTGAATG
2541

CBLB_3_
GTAGGAGAACAGAATAGGATTTATTTATATTATGACAAACGTGACTATCA

Exogenous_12
GTTAATAAATTGGAGATAGTAAGTTAAGATCATTATTTATATTATGGAAA

AATGAAGAAATAGGACATGGTTCTCTAACTTTTTAATTTTTCTGTGAAAT

AAAATATTATGACTTATTTTATTTTTATCTTTGTTTTTAGGTAAGACTGT

GCCAAAATCCCAAACTTCAGTTGAAAAATAGCCCACCATATATACTTGAT

ATTTTGCCTGATACATATCAGCATTTACGACTTATATTGAGTAAATATGA

TGACAACCAGAAACTTGCCCAACTCAGTGAGAATGAGTACTTTAAAATCT

ACATTGATAGCCTTATGAAAAAGTCAAAACGGGCAATAAGACTCTTTAAA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatGAAGGCAAG

GAGAGAATGTATGAAGAACAGTCACAGGACAGGTAAGAAGAATATTTCAG

ATGTTTTGGTGTAAAGGTCATTTATGTTGCTTTTTACTTAATAGTTAACC

TAAACGTCACCATGTAATTGTTTTGGGGTAAATGTGAGTCGCTTTGTATA

Tagtcatgtggtacttaacgatggggatactttacaagaaatgcattttt

agacaatttcattgttgtgtggacatgatagagtgtacttacacagagct

agatggtattacctaccgcacacctaggctgtatgatgtagcctattgct

cctaggctgcaaatctatacagtatgttactgtactgaatactgtgggca

gttgtaacacaatggtaagtatgtgtgtatctaaatatacctaaacatag

aaaaggtatggtaaaaatactgtataaaaggccgggcgtgg

(SEQ ID NO: 212)

pARBI-608:
AGATGAGAAAACCTATCCTTCCCAATTTTTTTGTGTGAGAATTAAAATGC
2541

CD2_1_
AGCAAGAAAACACACACTCATAAACACATCTGCTTTGGCAAAGGAGCACA

Exogenous_13_
TCAGAAGGGCTGGCTTGTGCGCGCTCTTGCTCTCTGTGTATGTGTATTAT

14_15
GTTTTATGTTACTGTAAAAGATGTAAAGAGAGGCACGTGGTTAAGCTCTC

GGGGTGTGGACTCCACCAGTCTCACTTCAGTTCCTTTTGCATGAAGAGCT

CAGAATCAAAAGAGGAAACCAACCCCTAAGATGAGCTTTCCATGTAAATT

TGTAGCCAGCTTCCTTCTGATTTTCAATGTTTCTTCCAAAGGTAAGCATA

AGAGTCAAAGAAGTCCCAACCCAGCTTTCCCTGAAAGTGACTCTCAGTAA

CTCTTTTGCTTTTTATAGGTGCAGTCTCCAAAGAGATTACGAATGCCTTG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatGAAACCTGG

GGTGCCTTGGGTCAGGACATCAACTTGGACATTCCTAGTTTTCAAATGAG

TGATGATATTGACGATATAAAATGGGAAAAAACTTCAGACAAGAAAAAGA

TTGCACAATTCAGAAAAGAGAAAGAGACTTTCAAGGAAAAAGATACATAT

AAGCTATTTAAAAATGGAACTCTGAAAATTAAGCATCTGAAGACCGATGA

TCAGGATATCTACAAGGTATCAATATATGATACAAAAGGAAAAAATGTGT

TGGAAAAAATATTTGATTTGAAGATTCAAGGTAAGTGTTCATTCCCTTAA

TTGCTTTATTTCAGTGTGGGTGCTATTTGGCAAGTTGGAAAATAGCATTT

CTAATATTCCCCAGCGCTGACCTCTGCCTCCAGGGGGGCTATACAGGAAA

CCAGATGCATGTCTCCTGCCCCAGTGGAGACTGTGGTCCAA

(SEQ ID NO: 213)

pARBI-609:
AGGATTGTTCTAGTTGATTGGTATGTGTGCACTCCTAGTTGTTAAATATT
2541

CD3_
TTCACTATCACACCTGGATATACTCAACAAATATTTGTTGAGCCAAATAC

E_1_
TCAACACCAGCCAAACACGTAGTATTTACTTTAGCTTAAGCGAATTATTT

Exogenous_16
AGCCCTGACAGAAGCCCTGGAATGTGGGTCTTTAAGTTCCTATTTTTGAG

ATGGGAAAGCTGAGGCTCACGGAAGGAGGTGACCAGCTCAAGTCTCCTAC

CGTCCATGCCAAATTAGAATTCCAGCCTGCCTCCTGACTTCAAGTCCAAA

GTTCTTCCCACGCACTAAAGCTAGCTCTTCAGTGTCCTTTCTTAGGAGGT

ACTTCCTCCCGCACCACTGACCGCCCCCTCTCTATTTCACCCCCAGCCCA

TCCGGAAAGGCCAGCGGGACCTGTATTCTGGCCTGAATCAGAGACGCATC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatTGACCCTCTG

GAGAACACTGCCTCCCGCTGGCCCAGGTCTCCTCTCCAGTCCCCCTGCGA

CTCCCTGTTTCCTGGGCTAGTCTTGGACCCCACGAGAGAGAATCGTTCCT

CAGCCTCATGGTGAACTCGCGCCCTCCAGCCTGATCCCCCGCTCCCTCCT

CCCTGCCTTCTCTGCTGGTACCCAGTCCTAAAATATTGCTGCTTCCTCTT

CCTTTGAAGCATCATCAGTAGTCACACCCTCACAGCTGGCCTGCCCTCTT

GCCAGGATATTTATTTGTGCTATTCACTCCCTTCCCTTTGGATGTAACTT

CTCCGTTCAGTTCCCTCCTTTTCTTGCATGTAAGTIGTCCCCCATCCCAA

AGTATTCCATCTACTTTTCTATCGCCGTCCCCTTTTGCAGCCCTCTCTGG

GGATGGACTGGGTAAATGTTGACAGAGGCCCTGCCCCGTT

(SEQ ID NO: 214)

pARBI-610:
AATAATAAAATAATAACAATACTTAACATTTATTGAGTGCTTATTAAGTC
2541

CD3_E_2_
TCAAGCACTGTCTGTACCCAACACTTATCAAGGATTCTTTTTCATGTAAT

Exogenous_17_18
CCTCTCAACAACTATATGGGTTAAGTATCATTTTATTCCCATGAGTAAAG

GGATGAGGAAACAGAGGGTTTGTGAGTTGAAAACACATTTCACGCTTCTC

ACAGCTAGTGAGTAATAAAGCTGGGACTCAAACCCAGGGCTGTTTGACTC

CAGTGCCTCTACCCACGGCCACCACTCTTTGCTTGTCAATGTTGTTCTAA

ACATATTGAAGGGGGGGCTCTGACCGTGGCAAGCGTGTGAGTAGTAAGGG

GAGAATGGCCTTCATGCACTCCCTCCTCACCTCCAGCGCCTTGTGTTTTC

CTTGCTTAGTGATTTCCCCTCTCCCCACCCCACCCCCCACAGTGTGTGAG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatAACTGCATGG

AGATGGATGTGATGTCGGTGGCCACAATTGTCATAGTGGACATCTGCATC

ACTGGGGGCTTGCTGCTGCTGGTTTACTACTGGAGCAAGAATAGAAAGGC

CAAGGCCAAGCCTGTGACACGAGGAGCGGGTGCTGGCGGCAGGCAAAGGG

GTAAGGCTGTGGAGTCCAGTCAGAGGAGATTCCTGCCAAGGGGGACGACC

AGCCTGGGCCAGGGTGGGTGGCAAGTCCACAGCTAGGTCAGAACAGCTTC

TCTAGAGCTTCTATGCACAGCTTCTATTACTGTGATGACAAGATCTCAAC

AGACGGTTTCAAATCTCACATCACTCCCCTCCTTCCCATCCTAGAAAAGT

GCAAAAAAGTTTATGAAAGTGATGGGCTTCCTCACATACCTGTCAATGCC

TGCAGTCATCCGATTCCGCCCCTAAGCTGTGGGAAGAGAG

(SEQ ID NO: 215)

pARBI-611:
ACTGTGACCCATGAACCAGTAGGTATTGGCGTCACCTGGGATCCTGACGT
2541

CD3G_1_
TAGTCTCTGTCAATCCTTCTCTTTAGTTCATCTATTCTACCCAAAGTGAT

Exogenous_19_20
CTCATCATCTGGTATGCTGTTAGCAGTTTCTTACCTGTATAGTATCTTCC

AAATAACATGCCCCAAAATCCCAAAGTTTTACCCCTACTAATTACAGCAA

TGTCTCTTTTATTCTTCACCCCCTGACGCAGATATTGGCGTCACCCGAGA

GCATGTTAGTAATGCAGAATCTCCCCTCCCCAGAACTACTAAATAGCACC

TGAAATTTTAACAAGATCCCCATGTGATTCATGTGCACATCAAAGTTTGA

GAAACACTACTCTAATGATCTCCTGGTATGCAGAAGCAGGGAGAATTTCA

GAGGCAAGATCCTTAATAGAACCACGGCTTTTCTCATTTCAGGAAACCAC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatTTGGTTAAGG

TGTATGACTATCAAGAAGATGGTTCGGTACTTCTGACTTGTGATGCAGAA

GCCAAAAATATCACATGGTTTAAAGATGGGAAGATGATCGGCTTCCTAAC

TGAAGATaaaaaaaaaTGGAATCTGGGAAGTAATGCCAAGGACCCTCGAG

GGATGTATCAGTGTAAAGGATCACAGAACAAGTCAAAACCACTCCAAGTG

TATTACAGAAGTATGTAATCCCCTTTGGTCTGTTTGTTGTGAAATTAATC

AGTATTTGCTGTTCTGGTGAGCTTTTTATCTGGGGTGAAAGTGGAAATAG

ATCCTCAACAGTAATATTATCGCCTGTTCTCTTAATTTCAGCTTGCCTCT

TTTAAAATACTGTAAGATACTTCCCTCACCCTATTGAAAAACTACAGCCA

GTCCTGTAAAATTTTGTTTACCTTTGGGTGGGCTCCATGG

(SEQ ID NO: 216)

pARBI-612:
TTCGAGACAAGCCTGGCCAACATGATGAAACTCTGTCTCTACTAAAAATA
2541

CD3G_3_
CAAAAAAAATTAACCAGGCGTGGAGGCGCGCGCCTGTAGTCCCAGCTACT

Exogenous_21
CAGGAGGCTGAGGCAGGAGGACCACTTGAACCCAGGAGGTCGAGGTTGCA

GTGAGCTGCGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGAAAGAC

TCCGTCTCAAAAAAAAAAAAGAGAGAGAGAGAAAAAGAAAAAAGACAGAG

CCTCCATCTCCTTGTCCTCTTTCCATCCTCAGGACCATGAAGTACCCACT

CCAAATTCTCACATATAAAAAACATTCAATAAACATGCATCAAATTAATT

AATAGAGGATGGAAAAAATGACTTATGACTGTGCTGTCCTTTCCAGCCCC

TCAAGGATCGAGAAGATGACCAGTACAGCCACCTTCAAGGAAACCAGTTG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatAGGAGGAAT

TGAACTCAGGACTCAGAGTAGGTGGGTTCTTCAATGCCAATTCTAATAAA

GGACCCTTGCATCAACTGCCCTCGCAATTGCTTCTAAGTCTAGCTCCCTT

CCCTAAGCGGCTATAAGCATCAGACTCTGGGGATCAGGGATTGGGACGTG

GTTTGGGGTACTCTTTTCTAAAAATTCTGGGGCCATACTGATTGTCTTGG

CCTAGGTAAATATGAATTTTATGTATCTGTAAATCCTGTCAGAGCAGGGC

CTCAAGCCATAGAGATGCTGAATATTAATCTTAACCTACATTTGAATTTC

TCATTATCTACACTATTAACATTTTGGGCTAATTAATTATTTGTGATGAG

GGGCTAGCCTGTGCATTGTAGGAGTTATGGAAGCATCCCTGGCCTCTCTC

CACCAGATGCTGGTAGATTGTCCAGTGTGACAATCAAAAAT

(SEQ ID NO: 217)

pARBI-613:
GACCTCAGGTGATCTGCCCGCCTCAGCTTCCCAAAGTGCTGGGATTACAG
2541

CD5_1_
GCATGAGCCACCACACCTGGCCTAAAATTAATTTTTAAAGATCTCTTAAA

Exogenous_22
AAGCAGACACCAGCCCCAATCTCAGACCCCTTGAGACAGAATTTCCAGGA

CAGGGGCCATCCTGCTGGACAGTGGGTGCCGAGAACACCTTGCCCATTTA

TCTGAGCTCCCTTCTGACTCTGAAATCTGGAGCCCCACCCTCCTGGGTCT

AGCTTCGGGGCTGCCTGGGTCAGGGTCCTCTGGGAAGCCCCTGCAGTGCC

CCAGAAGGGACGAAGCTCACAAGGGGCAAGGCAGGCAGCCCACGGGGCAG

GAGGGAGCTCAACTGGGCGTCCTAGGGAGAGGGCAGTGAGGGGTGCCAGT

GGGGAACCCCTCCCAGCCTGACCCCCACCACACCTTTCTGACCCCCAGAT

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatTTCCAGGCA

AGGCTCACCCGTTCCAACTCGAAGTGCCAGGGCCAGCTGGAGGTCTACCT

CAAGGACGGATGGCACATGGTTTGCAGCCAGAGCTGGGGCCGGAGCTCCA

AGCAGTGGGAGGACCCCAGTCAAGCGTCAAAAGTCTGCCAGCGGCTGAAC

TGTGGGGTGCCCTTAAGCCTTGGCCCCTTCCTTGTCACCTACACACCTCA

GAGCTCAATCATCTGCTACGGACAACTGGGCTCCTTCTCCAACTGCAGCC

ACAGCAGAAATGACATGTGTCACTCTCTGGGCCTGACCTGCTTAGGTGGG

TAACTAGCCAGCCACACGGGCACCCTGGGCCTGGGCGCCAGCCCCGAGGA

GACTGCCCGAGGCCTGTGATCTAGGGTCTGAGCAGGCTGGTGGAAGGGGT

GGGGGGACCCCAGTTTATAACCACTCCCCAAGACACATACC

(SEQ ID NO: 218)

pARBI-614:
GGACAGGGGCCATCCTGCTGGACAGTGGGTGCCGAGAACACCTTGCCCAT
2541

CD5_2_
TTATCTGAGCTCCCTTCTGACTCTGAAATCTGGAGCCCCACCCTCCTGGG

Exogenous_23
TCTAGCTTCGGGGCTGCCTGGGTCAGGGTCCTCTGGGAAGCCCCTGCAGT

GCCCCAGAAGGGACGAAGCTCACAAGGGGCAAGGCAGGCAGCCCACGGGG

CAGGAGGGAGCTCAACTGGGCGTCCTAGGGAGAGGGCAGTGAGGGGTGCC

AGTGGGGAACCCCTCCCAGCCTGACCCCCACCACACCTTTCTGACCCCCA

GATTTCCAGGCAAGGCTCACCCGTTCCAACTCGAAGTGCCAGGGCCAGCT

GGAGGTCTACCTCAAGGACGGATGGCACATGGTTTGCAGCCAGAGCTGGG

GCCGGAGCTCCAAGCAGTGGGAGGACCCCAGTCAAGCGTCAAAAGTCTGC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatCAGCGGCTG

AACTGTGGGGTGCCCTTAAGCCTTGGCCCCTTCCTTGTCACCTACACACC

TCAGAGCTCAATCATCTGCTACGGACAACTGGGCTCCTTCTCCAACTGCA

GCCACAGCAGAAATGACATGTGTCACTCTCTGGGCCTGACCTGCTTAGGT

GGGTAACTAGCCAGCCACACGGGCACCCTGGGCCTGGGCGCCAGCCCCGA

GGAGACTGCCCGAGGCCTGTGATCTAGGGTCTGAGCAGGCTGGTGGAAGG

GGTGGGGGGACCCCAGTTTATAACCACTCCCCAAGACACATACCCAGGAG

GGGGACTGGAAGGGGCCAGCACCCATCTGTAGGATGGCAATGGAGGACCT

AGTTCTGCCAATCACTGACTTCATCGTCGCCTCTGAACCTCCATTCTCCC

ATCTGTGAAGTGGGGTGGTACTTCCCGCCTCGCAGGAGGCT

(SEQ ID NO: 219)

pARBI-615:
tgctgggattacaggcatgagccaccacacctggcctaaaattaattttt
2541

CD5_3_
aaagaTCTCTTAAAAAGCAGACACCAGCCCCAATCTCAGACCCCTTGAGA

Exogenous_24
CAGAATTTCCAGGACAGGGGCCATCCTGCTGGACAGTGGGTGCCGAGAAC

ACCTTGCCCATTTATCTGAGCTCCCTTCTGACTCTGAAATCTGGAGCCCC

ACCCTCCTGGGTCTAGCTTCGGGGCTGCCTGGGTCAGGGTCCTCTGGGAA

GCCCCTGCAGTGCCCCAGAAGGGACGAAGCTCACAAGGGGCAAGGCAGGC

AGCCCACGGGGCAGGAGGGAGCTCAACTGGGCGTCCTAGGGAGAGGGCAG

TGAGGGGTGCCAGTGGGGAACCCCTCCCAGCCTGACCCCCACCACACCTT

TCTGACCCCCAGATTTCCAGGCAAGGCTCACCCGTTCCAACTCGAAGTGC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatCAGGGCCAGC

TGGAGGTCTACCTCAAGGACGGATGGCACATGGTTTGCAGCCAGAGCTGG

GGCCGGAGCTCCAAGCAGTGGGAGGACCCCAGTCAAGCGTCAAAAGTCTG

CCAGCGGCTGAACTGTGGGGTGCCCTTAAGCCTTGGCCCCTTCCTTGTCA

CCTACACACCTCAGAGCTCAATCATCTGCTACGGACAACTGGGCTCCTTC

TCCAACTGCAGCCACAGCAGAAATGACATGTGTCACTCTCTGGGCCTGAC

CTGCTTAGGTGGGTAACTAGCCAGCCACACGGGCACCCTGGGCCTGGGCG

CCAGCCCCGAGGAGACTGCCCGAGGCCTGTGATCTAGGGTCTGAGCAGGC

TGGTGGAAGGGGTGGGGGGACCCCAGTTTATAACCACTCCCCAAGACACA

TACCCAGGAGGGGGACTGGAAGGGGCCAGCACCCATCTGT

(SEQ ID NO: 220)

pARBI-616:
TGTCCAAAGTGTGTGTCACCTGCTCTGTGTTCACCCACTGGGTTCATCAG
2541

chr2_1_
AGGGGCACTTGAACAAAACAGGAATGTCACTGGAGAGGGGAACAAATGCT

Exogenous_106
GTCCCCAAGTCCTTCCCTGCCGTTTAGAGTAACGCAGCCCCTGTCCGCAC

ATCCTCACCCCCATCTGCCCTCTGCTTGCCAGAATTATCAGAATCTCTCA

ATTCTAATTTCAGCCATTCTCTGTGAAAATGAAAAGTTAGTGGCAGGCAA

TGGACACCCTATTGAAATAGAAATTGTTCTTCATATGTCAGAAAAGTCCC

AGAGTAATCTGGGAGTAATCTGAGCAAACTGATTCAAAGGATTATTACAA

TTTCTTAGTCTTCTACTGCTGCAAAAGTGGCACTCTTTGATTCTCATGTT

TGAGGTTCTAATTACTACCTCATGCAGGACTTACAAGAGATCAGCCATGC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatTGCTTACAT

TGTGTGTAGTGAATCAATGTTATTCTGAAGGGCCTCCTGGAAGCAGTAGG

GATTGGAGAATGTATGTCTTTTAACATGATCATTCCCATCCTATGGGGGT

TGGGCACTCTTAACTCATGTTGCAGATGAGTAAACTGAGGCTTTTGAGAG

TTTGAGGGTGCACAGCTTGAGGCAGAGGTGGAATTCCCAGCTTCATCCAA

GAAATCACGAATCTCCAATGGCTTGCACACATCCAGGTTTGCTGGATCCT

ATTTGTCAAGACCACATGCAGATTAGGAGCCTTCAAACAAATTATTTCCA

AGGGAGGGCATCTTTCTCTGTAACCCCTACCCTGGCAATTCTCCATGGCC

TCAGGGAGTCCAGCCGGAAGCTCTGCAATGAGTCCTGGGGAACTCTCATC

TGGAAAAAGGCGCTCATGACAGGTGGTGCCAACCTTCCACG

(SEQ ID NO: 221)

pARBI-617:
CTACAAGCATGCATCACCAGGCCTGGCTAATTTTTCTATTTTTTGTAGGG
2541

chr2_2_
ACAGGGTTTTGCTGTGTTGCCCAGGCTGGTCTCAATTTCCTGGACACAAG

Exogenous_107
CAATCTGCCTGCCTCAGCCTCATAATGTTTTTTTTTAATGTTAAACCCCT

TCTTGTGTTGAGAGGCCTGGCTTGTGTGTTTGAGCGCAGCTGCCTACCTT

TGCAGCTGTAAATGTCAGGGCTCCAGGAGGGCTGGCTGGGTCTCCCCTCC

TCCCCTGTTGGGTGGGTGGGGCCCTGAGCTTATCCAGGCATCCCTAGGTG

GATGGATGGGTGGATGGGTAGGCCCTGGCCTTCAGGGAATGCACTGTGTG

TGGTCTTCCAGCCCCAGCAAAGTCTCAGGGGGCCCGAGCGGGAAGTCGCC

ATCCTCAGGGGGTCCGAGTGGGGAGTCACCATCCTCACGGTCAGCCGTGG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatTTTCGAATT

GAGCTCCCAGGGGCGGAGACTCCATTCCCCCGGGGAACAATCTGATAGCC

AGAAATGAGAGCAGTGAGTGACTTGGACGCTGTGTGATTCAGGAGGGTCC

CAGTCCCTCAGAGTCGCCTGGACACCAGATTGTATTTACAAAACAGATGG

ATGAGGAAATGGAGATTGGGTCTTCAAAAGAATTAACCTCAGATTTTATT

TATTTATTTTAAAAATTTTAATTTTTCCCAAGGACCCTTTCCAAGTCAAG

AATTGTTTTAAAAAGAAGCCTGGTGAAGGCAAATGCTGTCTGTGGCCGAA

GGCACCGTGAGGAGCTGAGGCTGACTTATGTTTCTCCTCTGGGCTATGTG

CGCCTCTAAGGAGTTCACACACTTTAACCCCCTTAGGAACCCTACATGAT

CATCCTCGTTTCTTAAAGAGGAAGCAGAGCCAGCAAACAAG

(SEQ ID NO: 222)

pARBI-618:
TCTTGATGGATACCCATCCTTCTCTGCTGTTCTCTCTTTCCTCCATCCTC
2541

chr2_3_
AAGCACAGGGAGCTTTTGGCGAGGTTAGCTAACTTCGGGGCAGCTGTGAA

Exogenous_108
TTAGATACTGGCTGTAAGTTACCTCCAACATCCAGAGCATTTAAACGCTC

GGCTGTCAATGATTGTCATTTTCATTGTTTACATATAGTCACATCCTCAG

TTTGTGGGGTGGATGCATTTGATTCAATTCAGATATGCCTTTCAAGCTGG

CCCTGCTGAGCTGGGCCTGAAAGGCACATGGCTCATCTCATCTGCATGTG

ACAGTCTCTTTGAAGTCCCCAGAAGTGCCTGCTCAGAGTCATGCTCGGGA

GGGAAGAGGTAAGGCACAGAATGAGTACAGACTGCCACCCAGCCGCAGGA

AAGGTGACTGCACACCAGAGGTTCCTGGTAAGGAGGTGACTCACCCGCGA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatCTGTCTCAC

CTGTCCAAAGTGTGTGTCACCTGCTCTGTGTTCACCCACTGGGTTCATCA

GAGGGGCACTTGAACAAAACAGGAATGTCACTGGAGAGGGGAACAAATGC

TGTCCCCAAGTCCTTCCCTGCCGTTTAGAGTAACGCAGCCCCTGTCCGCA

CATCCTCACCCCCATCTGCCCTCTGCTTGCCAGAATTATCAGAATCTCTC

AATTCTAATTTCAGCCATTCTCTGTGAAAATGAAAAGTTAGTGGCAGGCA

ATGGACACCCTATTGAAATAGAAATTGTTCTTCATATGTCAGAAAAGTCC

CAGAGTAATCTGGGAGTAATCTGAGCAAACTGATTCAAAGGATTATTACA

ATTTCTTAGTCTTCTACTGCTGCAAAAGTGGCACTCTTTGATTCTCATGT

TTGAGGTTCTAATTACTACCTCATGCAGGACTTACAAGAGA

(SEQ ID NO: 223)

pARBI-619:
TGAGCAAATAGTTCTATCCTTTTTGACACATTTTCCACAGTTTGTATAAT
2541

chr3_1_
TTATTCATAGAATCCTTCTTAGACTACTAATAAATTCCTATGGGACATAG

Exogenous_112
TCCTTTTATATGCGGAGGAATCCACCACCATGAAATGTTCACAAGAAATG

ACTTTTAAAATTTTATTTGTGGCCATGCTGATTATGAATTTCTGAATTAT

GTCTGGGCTGCTCTTTTTCTCGGAATATGCAAAGTGGGATACTGGCATCT

CTGTATCTGGAGAGTTACAGCTTCTGAGTTAAAAGATGAATGGGAAGTAG

CAGGAGAGGGAGAGATCAGAAATCTCCACTCCCTGAAACACAGACACTTC

ACATACCCAGGAGGTAAATTCCTGGCATGAATTGTAACAAGTATACACAG

GCATTTGTACATTGTTTGCTTATGTGCTAGATGACATGGCAGTCTATGAA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatCAGGGGCCC

CACATCTGCAGGCAGGACATTCAGCCCTGTATCTTGCCACTACCATGAAA

TCTGAGGTTCTTTCATTTTTGTTTTTCTATTCTGATGAGATTGAGGTACA

CTGACTCACTGGTAAAGAAGACAATTTATTTGTGAACTTGTAGTCACTCC

ATTTGACGGCCTCCCTCTACTCACTGAGGCACAGCACGTGTGGAACAGGA

AAAAGGCCTCTGGAGAGCTTGTGTTCCACTGGTTTCTTTGACTTTTGCCA

ACCAACTTTGCAAATGTTCTCAAAAGGCATTCATTACCTCTGCAGGTGTG

AAATAACTCTGCAGTTCAAGGGTTTGTGAAATCACGTGAAACAGCTGAAA

GCTGTTCTGGCAAAGCGACCAGAGTCAGAGTTAGCTGTCACCAAGCCACA

TCCTGGCTTAAACGATGTTATTTATATCTAACTGCACTCGA

(SEQ ID NO: 224)

pARBI-620:
AGATGCCCATTGTACCACCTACCATTGCTTGACCCCCGCCCATGAGCTGT
2541

chr3_2_
TCCTTCATACTCATAACTAAAATGCCAAATGTGTGACTTGAGTAATTAAC

Exogenous_113
TAGAGACCTCCAGAAGGCTTTCCTTCTTATTCTGGGTACATTGATATTTA

CTTTAGTATTTGTTTTGCCTTTAAAGTCATGTTCCCTTTTGATTCTTTAA

TATCATATCCAAAACGAAGTCCTTTTAACCTATAACAATGCAAATCAAAA

GTGCTGTCTTTCAGCTACCTCAAGGATTTAGCAAGCGTTCCTGGAAATCT

AACCAACCTTTTAAAAAGTATTTCTATGGGAATGTATTTCTGAGCCCTAA

ATTATGGATTTTGAAACTAAAATAGAAGAATACTGTAAGTGCAAAACTTC

CAGTAGATAACAGAATTTGCAAAATCTCTAATCTCTTGTATGTGCCCCAA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatGTAGTACTCT

CTATAGGCCATTGGAACAGAACATCTGGCTTAAAATAATCTCAGCACCAA

AAACGGTCTAACTATGGTCTCCACAACATAACCCGATGGTTCTCATATTT

TAGATGCTTGATGCACAAGTTGAACTGGCTAACAATTCAGACTTCAGGAC

TTGACTCCCCTGGGAATCTGCAGTTGTTTCCCTCCCCTTGAGTGAGACTG

ACTGTTGGGAGTAGAATAACCGCATGCTCTGGGTCAGAATGCCTGGCCCT

TCAGAGTAACGGCAGCCATGATCGCTGAGCTCCTACTGTGAGGCACATAC

TTCGCCACACTAACACATGGAATCCTTGCAAGCTCCTTACATAATCAGTA

TTTTATGCACTTTGCAAATGAGAATACTAAGGCTCAGAAGAGGCAAGCTC

CTCTCCCACTGTTAAACAGCTAGTGATGAACAGAGCTGGG

(SEQ ID NO: 225)

pARBI-621:
ACTCCCCTGGGAATCTGCAGTTGTTTCCCTCCCCTTGAGTGAGACTGACT
2541

chr3_3_
GTTGGGAGTAGAATAACCGCATGCTCTGGGTCAGAATGCCTGGCCCTTCA

Exogenous_114
GAGTAACGGCAGCCATGATCGCTGAGCTCCTACTGTGAGGCACATACTTC

GCCACACTAACACATGGAATCCTTGCAAGCTCCTTACATAATCAGTATTT

TATGCACTTTGCAAATGAGAATACTAAGGCTCAGAAGAGGCAAGCTCCTC

TCCCACTGTTAAACAGCTAGTGATGAACAGAGCTGGGACCTAAACTTGTC

TGATTTCCCACACTGCTGCTCCATCAGATTGTTTGCCAGGTTAAGGATTC

ATGCCAGGACCTTAAATCCCTCTGAATCGACAGAGCTAACCTAAAGGGCA

CCTTGATTTCAGGTTTTGTTCCCAAACCTATGACTGTGGCCTGGCCACGT

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatAATGAAGAC

CCGGTTGGTTCTAGCTTCACAATGAGCTCATTGGCATTGTCCCCACAACC

ACCACCCCCTCTCCACCTCTGATCATCCACTATCATTTCTATATGGCCTT

TGCCAGGCTTGTCCTCATATCAAAGCTTCTGCCCTCTATGTTTAAATGCA

TAAGCTTGACAAATGTTTTCATTTGAGAAGGCAAGCTGCCTCCCCGTGCT

TGGTCTAATGTGAGCTTGGTAGAGTGACACTGCTGGATTCAGTTTTAGTC

ATCAACACTTCCAGCTGATGCTGATCTGAGTAATTGTCCTATTTAGACTC

TGACAGGTGAAAGTCATAGATTCAGGAAACGGAGACTCCCCTCACCCTGC

TATGAAGGGGAGTTTGAGAGGGTTGGGCAGCTCTTCCCGGCAGTGGCAGG

CAGTGTGGGGACACACGTATGGATAAATTGTTAATGCTCTT

(SEQ ID NO: 226)

pARBI-622:
CTGCAGGTGGCAGACTTACTCATTCTCATGCTTCAGCTCCAGGGGTTCCC
2541

chr3:
CTGTATGAGTCTTCTCTGCCCGCTCCCACACCCCAGGTAGCATTGCCCCT

1865_
GCTTGCTTTGTGCCCTCACTGTCTCCACATATATACACATCTCTTACAAT

Exogenous_109
AATATTAAATACCAGCCAACATTTATATAGTACTTCTTATGTACCAAGTA

CTGTTGTCTATCTATCTATCATCTATCTATCTATCTATGTACACACACAC

TCATATTATCTTCACAATGCTATGAAATAGGTATTATTGCTGTCCATTTT

ACAGATGGGGAAACCAATCTATAATTGGTTTAGTGAGATTTACTGAGCAT

ATCTACAGGTATTTGTCCTTGGTTATAGGAAACCAATCTGTCACTGGTTT

CCCCTTCTGTAAAATAAGTTAAATAATTTGCTTAAGCTCACTCAGATAGT

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatGTGTGGTTGA

GTCATAATCTGAGCTACTCTCTGGCCCAAACTGCTTATTGTAACCACCAC

ATCATATGGCCACTTCAGCACCAGTCACACCTCATTTTACTTGTTGATGT

CTCAGTTTTCCCCTCTATTCTGCGGGCTACTTGAGAAGACTTCTGTCTTC

TTCCTCTAGGTATCTCTGTGCTTGACTCAGTATCGAGACCATAGGTGTGT

GGGTGGGGTTAATCCACACTTGCTGAACACATGTGTCCGTGCCCAATGTC

CCTGTGCATAGTGGCTACTTCCCATGGTTCACACGCATCTTCATGGCTCT

TGTTTCTTCCATTCACCCATCCCATGTCCCTGGCCCTGTTCTCAGTGCTG

AGGATGGAACCTCATTGCTGCTGCTTCCAGCCCTGGCCCTGCCCCTGTTT

GGGGCTCAGTGCTTCATCCCGTGGAGCTCAAGGGGTGCTG

(SEQ ID NO: 227)

pARBI-623:
CTTCTCATCCTCACACCCATTCATTTCTTAGTTTCCCATACTCTGACTTC
2541

chr3:
TACTACCCCAAGTTCATAAAGACCTCATGAACACAACCTGGAGAACGCCC

1865_
TCAGCCTCATCTCACCTCCCTGCAACACATGGCTCACTTGTCTGCTTCTT

Exogenous_110
CCTTCTTAGAGTCCTCTCTCTGGTTGACCTGTCAAAGATGGGATTCTCCT

GTTAACGACCCTGACTCCTTTGTCTCCTTCTACAAAGATAATGCACTGAC

TTTCCAAATGTACTAACTAGTATGATCATCACTGTCTACTGTTGCATCGA

ACCACTACTAACCTCAATAGGGAAGGCACCAGGTTCAAGAGGCCAAAGAA

GAGACCCAGAGCCAGCAAATGAGACATGGGGTTTTATGAGGGGCTCACAT

AGAGGGGAGAGAGTCCAGTGGCAGTGGGCTGGGCAGGAGAACCACCTTAC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatACGTGGTCC

AGTGGTGGGAGGCTGGAAAAGAGATCTGTCTTGCCTACAGTTCAGTGGTG

GCGGGTTGGGCAGGAAAACCACAACTGCCTGCAAACATCATGCAGTTTAC

ATAACATTGTCACTTAGCAGCCTCCCCTAACGACCTCCACCTGGCAATCT

TCATTTAACCCAAAACTCAAGGCCTCAATCCCCTGTATGGACCATGTTTC

ATGGGACAGGCCAGGGGCTCAGAAGTTTATCATAGATAAGGAATGAATCT

CCGGGTTGGCCACTCCTGGATTCCCTAGCTTGGAACACACATTCAAGTGT

ATCTGCCATTCTGAGTGTATTCTTCAATTATTGCTGTCAGGTGTGTTGAC

CCTCTATCTACATAAGTATTTCTCAAACCAGGGCCCTACGATCAGCATCA

GCATCACCTGGGGTATATGTGAAAAATGCAGCTCCTGGACC

(SEQ ID NO: 228)

pARBI-624:
GGGCCAAGCAAGCTCTGAGACAAGCTGTCTCACCTCCTCATCTCCTGAGC
2541

chr3:
ACAACTCACCCACAGCTCTGCCCTCGCCTCCACCTACATCATGCCTTCCT

1865_
GCATGCCAACTTCCCTCTGAGGTTCCCTTCACCCACTTACAACCACAGCC

Exogenous_111
TCCTTCCGGACCTCCCCTACACGATGAACAGTCTGCCAGTTAATATACAT

CAAGCTGCCACCATGAAACAGCTCGGAAAGCCCCATTTGTTCTCAATAGC

ATTCCAGCTAGAAAGACCATCCACCACCCATGGCCACTGAAGAAGGTCCT

CCCCTGAGTGCCAGGCAGTGGGGCTCCTAACTCTGGGCCCCAATTAGCTT

AGCTTGGGGGAGCAAAGGACAGGAGCACTGTTCACCCAGTTGGACTAACA

GCTCCACACTGTGCCTAATAGGAACCTCCTTCTCACAGGTGGCACCTTTG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatTGAATCAGG

GTCTGTCCTGAGCCACCCTCCCTTGGAGAGATCTGAGCACTGAGAACCAC

AGAGCCTGGGACACCAGCACAGGGTTTGAAAAACTCCACTCCCAGTCAGC

TGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGT

GGATCACAAGGTCAGGAGTTCGAGACAGCTTGACCAGCATGGTAAAACCC

CATCTCTACTAAAAGTACAAAAATTAGCCAGGCATGGTGTTGGGCACCTA

TAATCCCAGCTACTCGGGAGGCTGAGGCAGGGGAATTGTTTGAACCTGGG

AGCTGGAGGTTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGCCTGGG

GGCTGAGCGAGATTCTGTCTCAAAAAAATGGGAAAAACATCATTCCCATG

TGTGTCCTGGTTGCTTGTCTCTTTCAAAGTACTGCATACT

(SEQ ID NO: 229)

pARBI-625:
CCACATCATGGACCAGAAGCCACTTGGTCTGGTTGTGAGGATGACGGAAC
2541

chr8_1_
CTTGCCCGAGGAAATGGGCAATGAACAGGAGCCTGTTTGTTTCTCCTTCC

Exogenous_115
AGCTCCTGACCTGTCTAGCTCCTGACCCTCTCAGTGTCATTCTTGCTCAC

CCCTGGCCCTGCTCCCTGGATATGCAGACAGGATGGGCTTCTTCCCTTTA

GACCTTCACTTTGCTCTTTTGGACTCCTCTTCTGGCCTTGCCTTCCCCTG

GTGTCATCTGCTGGCTCCCTGCCTGATACTGCCACACTGGTCATGCTGGC

CTCCTGGCCTTTGGTGACACCGCATCAGCAGGCTCCTGCTTCCCTGTCAA

GGGATACAAGCCAGCACCGGTCTTTCGCCACAAGGTATGTGTGTAAAGAT

TGCTTCCTGTACTTGGTGTCCACAGGATTTTAAAGAACTCCTGGCCCACT

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatCGGAACTCT

ACGCTTGAAACAGAAACATCTTCTCAAAACACCTCTGGTATTGGCCCATT

TCTCTATTACTGTTTCTTGTGGTTTCATACTGAGGTTTTTGGTGCATTGC

AATTGCCCTGGAGTTTATTTTTAGTAATAAAGACAGAGTTCAATTAATGT

CAAAACATGAGGGTAATTGCAGAGGAAGGATTAGTAAGTCTAGGGGAAAA

TGTGCCCAACTTTTTTTCTTCTGATAACATCTTTCACTGATCATACACCG

TCACACCCACAGACACGGAGCTTCCTCCGTGATGTCTGCAATGCACTAGG

CCCAGTCGGGGAGCAGTGGCTGCGCCACCACCTGAAAACGAAAGCATTTC

TGAGTCTCTTTCAGTCCAGCTCATCTAGCAGCCAGCCACACAGGTGACCA

CCCACCGTAGCTGTCACTATGGGTGATGATTATCATTATGG

(SEQ ID NO: 230)

pARBI-626:
AGGATCTTTCTCTCTACAGTGCCTCTTGTGGGACGGGTTCTGCTGATGGG
2541

chr8_2_
GGCTGTGTTTGGGATCTCGCCTGGAAACACGATCTCTCCAACTTTCCCTG

Exogenous_116
GGAGCAGAGCCTTGGGTCTCACTGAACCCACCTCCCCAGCACCTTGTGTG

GTGACTGGCAGGAGGTAGCCATTCCCTCCTGTCCTCTCTGCCCTTGTCCA

CTTTCCTGTTATGAGTCAGTTGCTGAGATAGGCTATGAGGAGTTAACAGA

GTGGATAAAAAAGAGCTTTGTCCTTCTTTAAAGCCTTCAAAATATACAGA

TGTATTAGTCAGGGCTTTCCAGAGAAACAGGACCAATAGAACATGAAGAT

AGATGCGTATCCATGTCTATATCAATATCTACCTTGATATTTATATCTAT

ATCTAGGAGATTTATTTATTATAAGGTATTGGCTCATGCAATTATGGACC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatCAGAGGGGT

CCTGTGATTTGCCACCTGCAGGCTGGAGACCTAGGAAACAGCTGTCGTGT

CACAAAGGGCAGAGGGCTGGAGAACCTGTAGTGTAGATTCCAGTCCAGAT

TCGAAGGCCTGAGGACCAGGAATGCCAAGGGCAGGAGAAGATCGATGTCC

CAGAACAAGCAATCAGGCAGAGATGAAATTCAACCTTCCTGTGCCTTTCT

GTTCTATTCAGGCCTTCAGTGGGTTGAATGAGGCCCAACCCACATTGAAG

AGGACCATCTGCTTTACTCAGTCTCCTGGTTGAAGTGATAATCTCATCTG

GACATACTCAGAAATGCTGTTTAACCAGCTCTCTGGAAATCCTGTGGCCC

AGTCAAGTTGACACACAAAATTAACCATCACACTGCAGAGACACAGTCTA

TCCCAATACCTGTATTTACTGGGTAACGTGCATCTCAGCTC

(SEQ ID NO: 231)

pARBI-627:
TAATAATGACTCTGCTGGTAATTTGTGTCCTTCTGCTTGGAACTGTTTCC
2541

chr8_3_
TTTTTAGTTTGGTCACCCTCCCAGAGCTGGTTTCAATGGGGGCATACCCA

Exogenous_117
TTATGGGATGCAGGGCATCCTGCATCCTGAGGAATTTTTTTTCCTCCAAA

AATGAAACCTTGAAATGAGGACATTGTCCTGTCCACGGACTGCACAACAA

CACTGAGCCTCAAGGACTCATACTGGCATTTTTCTTCTTTTGCAGAGTGT

GGGCACCCTGGCTTCAAGCTCACGAGAAACCAGGTCGGGATTTAAACAAT

GTTGGGTTAAAGCAAAGTTTCATAAAGACAGAATCAAGAAAAAAAGAAAG

AGAAACCAATCTAAGTGCCATCCTCCCTGAGTTGCATCTTACCTGAGTCT

TCAGCCGCCGCCCCCTGCTGCTGTGGGAGGAAACGGGAAAGTGACTGGCC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatATGGGGACA

GGGGTCGGGGGTGTGAGGGTTAGTGGTAGCAGGGAGGTAGCACTTCTGTG

AAGCCGGAAAGGAGACCTGAACCTGGCTCTCTGCTTTGCTGCTTGCCAGC

CCTCTGGCTGGGAAGAAGGCTCTTGGCTCTTGTGAGCCTCGGTTTCCTCT

GCAGAGTGGCCTGTTCTGAGGACAGGCTGACATTGCTGTCCATCAGTCTT

CCAGGACCCTGAGGATTTCAGCTCTACCCATGGGCACTGAACTGGAACAT

TCACTGGTCATTTGCTTTCGTTTTTTTTTTTTGTTTGTTTGTTTTTTGAT

ACAGAGTTTCACTCTTGTTGCCTAGGGTGGAGTACAATGGCGTGATCTCA

GCTCACCACAAGCTCTGCCTCCCGGGGTCAAGCGATTCTCCCCAGTAGCT

GAGATTACAGGCATGCGCCACCACGTCCGGCTAATTTTGTA

(SEQ ID NO: 232)

pARBI-628:
AAGTCAACAACAGGCTCCAGAAAAAAATGGAAATATAAATGGTCCCCAAT
2541

chr9_1_
TTGGCATTTTGGAATTTGAGGCTTATATAGTATGAGCAAAATAAACTCCT

Exogenous_118
CCTGCTTCTATGAATTCTTTGCACTTTTTCTCTATAATTCCTTATCAAGC

AATGGGTTTGTCTGTTAACCAAGACTATACATAAAATGTATTCCCGTAGT

TCCTTTTATTACATTTTTTCTTTGTTGTTACTAGTGGAGAAGCTAACAAG

AGCAGAATTTCCTGCCCAACCGTAGCAAATACAGAAAATCAAAAAGAGAA

GCTTTGATACAGCCAGTGTAGATACAGCTAGGACGTCATGAATCAGAGCT

CCCACACACGATGATAATGGAAACATCTTATCCATATCTGATTTGCTCAC

ATATAGTTATTTAGACAACAAATTTTACATTCCTGGATAGGGAGCCTCCG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatATTTGATTTC

AATCTCATAGTCCAGGTAGGTGTAAAATGACTGCCAAGCCAGCAGACATA

AATCTGTATTATCTCATTTTCATCACAGTCTCTGCATTGGGAAAAAAATG

TGAGTGAAAAGACATTTTCTCCCACCTTGTTAAGTACACAATTACATAGT

TTAAAGAAGATAAGAATTTCAAATTGTTAGAATGATATCATTATTCAAAT

GATTCCCTGAGAACTTCAAGTATTCCCCTTCCCCCAAATGTAGGCAGGGC

AAAATAGAACCAGTAGGAATGAAAAATGTTAATTGTTTCAGGTTCTGTAA

TTTTGGGTTTAATGACTCAGGCTATGTGCTACTGAGTAAAATACTCATCT

GGAGAAAAAGACTGTTGCATGACATATTTCTGATTAAGGACAATTTAAAC

TAATTCTAAGAAAACTCTTACATACTGCACATGCCATAAA

(SEQ ID NO: 233)

pARBI-629:
GATTAGGTCTGGAATAAGATTGCACCATGACTAAAATGACTTCTTTAGCC
2541

chr9_2_
AATGACATTCCTGAAGATTGGATCAGAGTAAAGTTAAACTAACCTACTCA

Exogenous_119
AGGAAGACTTTCCTAAATCAGCCCCTTTGCTGTATAATTTAGTATGGAGA

GCTGATTGTGGGTTTTTCTTGTTTCATTGTTTAATACATAGAGGTTTCAC

ATTTCATTTTGAAACAGAAAGAGGGACTGGAAGAGATAAGTTAGTATGAG

TGAGGAAAAGATTAGAAGGTAGAGATAGGATCGCAATGCTGTTATCACCT

TTGCTTTATTGATAATCTCAGGAAGGACTAGACTGCTAAGAAAGAGGAGC

CCAGATTGGAATAAAAGAGACGATGCCAGGATCAGCCTGTGAGAGGATGT

CTCACTTAGTACACCTCAAGGATCATGTCAGCTGAGCATCTATACCCCGC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCG

AGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGGGC

GAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACCAC

CGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTACG

GCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACTTC

TTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTCTT

CAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGGCG

ACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGGAC

GGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAACGT

CTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAAGA

TCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACCAG

CAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCACTA

CCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGATC

ACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCATG

GACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaata

aagcaatagcatcacaaatttcacaaataaagcatttttttcactgcatt

ctagttgtggtttgtccaaactcatcaatgtatcttatGTGATGAATATT

GCATACAGACTCTGCCTTCAAGTCATCCCCCATTCGACAAGCATTTATTT

AAGGTTCTTACATTCCAGGACTTGTACTAGATGCTAGAAACAAACAGATA

AGGAAAACGTAGGAAAATGCTTCTCTCAGGAAGCAATATTGTATATGAGT

GGTGAAGAGCTTCAAATCTGGGGCCAAACTGCTGGGTTTGAAATTTGGCT

TGGCCACCTACTGGCTGTGAAATCTTGGGCAACTTTCTTAATCACTCTGT

GCCTCAGTTTCTTCATCTGTAAAATGAAATAGCCATAGTACTTATTACAA

ATAGGTAATAATTAGTGAGAATTAATTTGAGTCAATACATAAAAATGACT

CAGAATAAAAGACCAGCTAAGAATATATACACACATACTTAGCTACTTAT

AATCTAGTAGGAAAGATGGGTATGTTATCAGAGGACTT

(SEQ ID NO:

234)

pARBI-630:
CAGATAAAAAAAGCTGAAGCTCAGGGATATTGTCATTTACCCATGAGCTC
2541

chr9_3_
ACAGGCAGGAAGTGGTGAAACTATCATTAAACTACGGTTGGCCTTGTTCT

Exogenous_120
TTTGTGGTTTCATTTCACTAAGCCTCTGACACCCTGACCTCAACTTCCTT

CTGTAGATATGTCACCTGGCCTCCTTCAGTCTAAGACACTACACACTGGC

CACACACTTTGTCATCCTCATAGACTGACAACCTGCTCTCACATACCCTG

CTTTCTTACTGTGTAGGCTCTCTTTTCTTGCTCAGAATGTCCTTCCCCAC

TTCTTCATGTGCCAACTCCTAGTCATCCTACAAGAACCACATTCACTTTA

AGTTTCTTTTGAAGCCTTTTCAGTGTCCCATACCCTGATCCCATTACCTC

TTCTATGTATGCAGGGCTTGCTTCATGCTTGTGTAACCCAAGGGCCCTGC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatATTTGATTTA

ACACATTTTAAAATTCTTAACAATTTATGAAAAAGGAAACCCATATGTTC

ATTCTGCCCTGGACCCTGCAAATTATGCAGCCAATCCTGTGTGTGTTTTT

TCATGTTGCGTAGACTCTATTACAGTCAGTAACATATTGAGAAAGAGTGT

GTGTCTCCTCTGATAGTCTATGAGCTCCTTGAAGCAAGAGGCTTGTCTTA

GTCATTGCTGTATCCTCACACCAGACTCTACGGGATGCTCAGGATTCACC

TGTTGATCTGTGAGGAAGCCCAAGGCTCAGTTAATGCCCCCCACCCTCCT

TCCATAACAGTCTCCTGATTAGGAAACAGTGCTTGACCTCTAGACAATCT

GAGTATCCACTCCAGGAAGTGGAACATTGCCTTCCCAATGTTGAAACTGT

TAGCACTCAATCATGTTTCAGGAACATATAGAAGGTATGT

(SEQ ID NO: 235)

pARBI-631:
TGGACCTTATGCAGGGTAATAAAAACCAACACGTGGGGCCTGTGCTGTAA
2541

chr10_1_
GGTGGCAGAGGGCGATGACTCACCCCACTCATGCAGGTTGAGTCATTTCA

Exogenous_90
AGGCAGAGTTGTGCCAGTTCAGTACCCAGTAATATTTTCCAGTCGACGAG

TATCAGTGAACAGGAGATAACCAGTCATTTCTAGATTCTGCTCAGAGTCC

CAGCTTAGAGGCTCCACCAGCTCAAAGAGACGGGATGGCAAAACAGCCAC

CTTAATTTCCAGATCATCTGCCAGCTCATCTGCCAGCTGACACACAGCCC

ATGGCTCCACTATTGCCAGTGCTGTAGCTGCACCAGACCAATCTGGTTCA

ACTTTTATGTAACAAAGTTGTGATTTGTTTTTCAGTTGCCCGGGACTCCC

AGGTTGAAGATCATGAGCATGCCCTGATGAGCCAAGGCATGCAACCACAG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatGGGAACCTA

AGTGCTTGGACTGAGGAGTGGGGACTGAAATAAGAAGCGGACACTGCAGG

GCAGGATCAGGATCCAATCAGATCGAGCCCTGGCATCACCTCATGGCAGG

ATCTAGTCAGATCGTGGCTTTTGACATCACTTCATTGTGAAATCCAATCA

GATCACACCTTATTACCCTATCCTTATAAAACCGGACCTAGCCCCCAGCT

CGAGGAGGCACTGCTTTGGGAGTTATCCCAGGTGTTCTTGTTACTAGTTG

CAAGGAATAAAATCCTCTTGCTAAATCCTCCTTGGTTGTGCAGATGTTGG

CATGGATGTGGAGAGAAGGGAACACTTACGCTTTGTTGGTGAGGATGTAA

ATTAGCTCAACTCTGTGATAAACAGTATGGAGAGTTTTCAAAGAACTAAA

AATAGAACTTCTACTCAACCCAGCAATCCTATGAGTGCATG

(SEQ ID NO: 236)

pARBI-632:
ACATCTAATCCCACACCATGACTAATAAACATGGCATGCTGCAATGGGCA
2541

chr10_2_
TTAATTTATGGGTAACAGAAGCAGATCCAAGCCTTTTAGCTAATTAAATA

Exogenous_88
AAAATGCACCATACAGCAACCATCCTGCCTGCTTGGGTGTAAAATAGAGA

GGAGAAAGATGGCATGCTGGTCATTGAGAGATAATTACCTGCAATTTCAG

AGCTGGAATCTAGTGACAACATAAGAAAAATAATAACCTCTCTGGCTGTT

AGGATTCTCAGTTCTAGCTGCGAGCAAGGAGCAAAGGCACCCACAGACTT

GCCAAACCTATGTCAGGAATGACGAATAGAAGGCAGAAATCCACATCCCC

AGGTGGTAAAATTGTTATCCACCTTCGTCACCTCTTTCCTAATGGAGGAA

GTGAGGACAGGCAGCCTTGGAGTCCTACTTGAATGAGGCCTGGACCTTAT

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatGCAGGGTAA

TAAAAACCAACACGTGGGGCCTGTGCTGTAAGGTGGCAGAGGGCGATGAC

TCACCCCACTCATGCAGGTTGAGTCATTTCAAGGCAGAGTTGTGCCAGTT

CAGTACCCAGTAATATTTTCCAGTCGACGAGTATCAGTGAACAGGAGATA

ACCAGTCATTTCTAGATTCTGCTCAGAGTCCCAGCTTAGAGGCTCCACCA

GCTCAAAGAGACGGGATGGCAAAACAGCCACCTTAATTTCCAGATCATCT

GCCAGCTCATCTGCCAGCTGACACACAGCCCATGGCTCCACTATTGCCAG

TGCTGTAGCTGCACCAGACCAATCTGGTTCAACTTTTATGTAACAAAGTT

GTGATTTGTTTTTCAGTTGCCCGGGACTCCCAGGTTGAAGATCATGAGCA

TGCCCTGATGAGCCAAGGCATGCAACCACAGGGGAACCTAA

(SEQ ID NO: 237)

pARBI-633:
TGAGGTCTTGGTATGTTGCCCAGGATGGTCTCAAACTCCTGGGCTCAAGC
2541

chr10_3_
AATCCTCCTGCCTCCACCTCCCAAAGCGCTGAGATTATAGGCATGAGACA

Exogenous_89
CAGAGCCCAGCCACTGTCCGCATTTCTTTCCTGGCTTCCTTACTGGGTTC

TCTACTTTCACTCTTGCCTTCTTCCTCTCTTCCACCAGCATAAGTTTTAG

AAACTGCACTTCTGATCATGCTGCTCTGCTGCTTAAAATCCTTCATGCAG

ATCATGTAAGACCTTCCTGATCCAGTGCTGCCTTGCCCTCTAGAACCCAG

GGTGCCTTTCTCCCCTCTGCAGTTCTACTGCGCCACCTGCAGTTTCTCTC

TCCTGTGTTCATGTGTCTACTCCCTCTGAATGGTAGGCTCACACCCTCCA

CCTGGCCAACTCTTACTAAATCTTGGGCTTCAACTCAAGGATCACCTTCA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatTGGTTCACTC

CACCAGGCTGGGCTGTGTGTCCTGCCCAGTTCCTATAGTGCCCTAACTCA

CTTTTTTAAAAAAATACTTTAAGTTCTGGGGTACATGTGCAGAACATGCA

GGTTTGTTACATAGGTATACACTTGCCATGGTGGTTTGCTGAAGCCATCA

ATGTCATCTACATTAGGCATTTCTCCTAATGCTGTCCCTCCCCTAGCCTC

CCACCCCCCAACAGGCCCCAGTGTGTGATGTTCCCCTTCCTGTGTCCATG

TGTTCTCGTTGTTCAGCTTCCACTTATGAGTGAGAACATGCGGTGTTTGG

TTTTCTGTTCCTGTGTTAGTTTGCTGAGAATGATGCTTTCCAGCTTCATC

CATGTCCCTGCAAAGGACATGAACTCATTCTTTTTTATGGCTGTCCATTA

TTCCATGGTGTATGTGTGCCACATTTTATTTATCCAGTCT

(SEQ ID NO: 238)

pARBI-634:
CCTTCCACCCCCTTCCTTAATAGTTTTCCTCCTCCGCCTCCTGCACGGCC
2541

chr10_1_
TCCGCCTCCGCCTGACCGTCCTCGGAAACCTCCCAGCCGCAGCCCGGCCC

Exogenous_92
TCCCCAGCGGCCTGAGTGGCCTCCTCCCGCGGCGCCCCCCAGCTCCGCAC

CTCCCCAGCCCCGCCCGAGGCGCGCCCAGCGAGCGTGACCCCGACCCAGG

GCCACGGCTGCGCCCGTAGGATCGCGGGCGCGCGGGTCTCCATGAGGGAC

TGGGAGAGATGCGTCACCCGCTAATCCCTCAACTGGGTCGCACCCGGTCT

GCCTTGGTTGGTCCCTTCTGATGGCGGAGGCGGGACCTCGACTTGGTGGC

CAATGAGGAGCCTCGTGGGGGTGCTCTCGGCTGCCATGGCAACGGAGGGG

CCGCCCGCTTCCCCGCGGGGCGAGGCCGGCTCTCCCAGGACTGGCCACAT

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatTGCAGTCAC

GCGCTGTGGCCCCAGTCCTGTTAGCATGAGGTGGGGGTCAGAAGTTGAGG

AACAACTCGGACCTAAAGCCTTGACAATTGCCAACAGTGTAGACAAGTCC

CAGCATGCCCAAAATTTATAAGAGAAGGCTGCCTGGAAGAGGGACACGAT

GAGGAGGGTCTGCTGAAACGGACAAAGAAACCCAGTTCAGTGCAGTGGAG

TGGACATGGCACGGGCAGGGCACGGAGTGGGGTCGGTGCTTAGTAAGCGG

ATTAGGGTTTCCAAGCCAAGACCCACCCAGGGCAGGATGGGGAACCAAGG

TGAGCAGGTGCGCTGAATTGTGGGTCTCACACTGTCCTTCAGTGTCCCGC

AGGAAGAGAGAGCTAAGGATCACCAGGGTCATTCCCCTGCCTCAGGCAGC

CTGCACTCCACCTTAGGTACAGTCATGTCCGGTCTTCAGCA

(SEQ ID NO: 239)

pARBI-635:
TGATCCTCCCACCTCAGTCTCCCAAAGAGCTGGGATTACAGGCATAAGCC
2541

chr10_2_
ACCTTGCCCCGCCAGTTTTTAGCCTGTCAGCTCTTTGAGGGACACTTGTT

Exogenous_91
ATGGTCATACCCACAGCTTTGACCCTTACCAGGTGGTCAGGTGGATGAAT

GAATGAGTAGAAAGAAGGAAGAGAAGGCAGGAGGGAGAAGAGGAAGAATG

AAGGAAGGGTTGAGTTTGTTCTGGAAGCTCCCAGCTTCCATCCGCACCAC

ACTCTCCCTCTGTCCCCAGGACACCAGGGAACTGACTCAAGGCTCTCCTC

TTACCAGGTGCTGTGTGGGGTCCAGGGAGAAGAGCCCATTTGAAATGGGG

CACTGGTCTAAACTCTGGACCTGCTGCTCACTATTGACTGAACTTAGCCA

CTTAAATATTCTCCTCTATAAAATGGGAGTGACCATAGCAACTACCTCGC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatTGAATTGTA

GGGAGACCCAAAAAATGTATATGAATACATTTGTCAACTAAAGAGTGTTA

GGGATTATCTCAGTGGAGGGATAGGCAGTGCAGGCTCTGGAACCAGACTT

CTTGTGTTCACATCCCTGCTCCACTGCTTGGAGACCTTTGGCAAGGTCCT

TAACTCCTCTGGACCTCAGTTTTCTCATCTGTAAAACAGGGATTATACTA

GTTCCTACCTCACAGAGTTGTGAAGATTAAATGAGATAATGCATGAAAGG

CTTTTCAATAAGAGCAGGGCACACATTAGGCATGATGTCCATGATCAAGT

GCCTAATATGTGCCTGCTCTCAGGAAGGATGCTGTGAACTACTTCACACT

AAAGTGTAAATGAATGATAAGATCTACTATGCTCCACTCATGCCTGTAAT

CCTAGCACTTTGGGAGGCCGAAGCAAGTGGATCACCTGAGG

(SEQ ID NO: 240)

pARBI-636:
GGTGAGGTCACCCTGGGTACCTGGAGTTACTCAGAGTGACACTAGTACAC
2541

chr10_3_
GCCTGGCAGGAGTGATGGATGAGCTAGGCTCCAGGAAAGCAGGTGGGGCT

Exogenous_93
GGAAACCACCCAAGACAAGGAAATTGTTGGGTTTGAAATTCCAGGTAAGC

AGAGTATGGCCTGAGAGCAGCGGCAGAGGCTGAAAGTGGGCTTGGTCTCG

GTATTTTTGAGGCTGAGGTAGCTCCAACTCTCTCCCTCTGAGTCAGCACC

CCACTTAAGACAGAAATACTGAGATCTGCGACCCCAGCCTCCCCCACAGC

AACTCCACAGTCCCCAAACCTTTGCTCCGCTGGGTCCTCCCAAGTATGGT

AGCTGACACAGCCCTGAGCAGCCCACTGTCCTCTGCCCTGCCAAGTCTTC

TCACTCTTGTCACTTTGTCCTACATCATTTCTTTGTCTGGCACCCCTCCT

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatAGAATTGGT

GCCCCAGAGGTGGGAAAAACCTACCCTGCTCACTGCTCTATCTCCTGGGC

TTAGCTCAGACTCTGGCATACGTGAGTGCTTAGTAGAAACTTGATGGGGT

ATTAAAATTGAGACCTGGGTGGGTTCTCACATTAAATTTCTAACACTCCT

TAGGTGGCTTGGGCCCACCCCTCTGAGCCCTGTTTCCACATCTGTAAAGT

AGCAAACCATCGCCATGAAGAACAGGGAAGAACCAGGTCAGCAGGCAGGG

CGGATGAAGCATCCAGCCAGTTCTAGGAAGTTTCCGATGGCTAATCCTTC

AGATGCAGCTTGTAAGCAGGTCAAATACAGAATAGGAAACTGAGGCGCAA

CGAAGTCATGCTTAGAAGTCTGTCCAGGGAGACCAGTCAAGGCCTCCCCC

ACACCCTGCAAGCCCTTCTAGGAGCTCTGGTTAAGTCACTC

(SEQ ID NO: 241)

pARBI-637:
ATCTTCAAATTGTAGTCTTTGTAACAACCAAATAACCTTTTGTGGTCACT
2541

chr11_1_
GTAAAATTAATATTTGGTAGACAGAATCCATGTACCTTTGCTAAGGTTAG

Exogenous_99
AATGAATAATTTATTGTATTTTTAATTTGAATGTTTGTGCTTTTTAAATG

AGCCAAGACTAGAGGGGAAACTATCACCTAAAATCAGTTTGGAAAACAAG

ACCTAAAAAGGGAAGGGGATGGGGATTGTGGGGAGAGAGTGGGCGAGGTG

CCTTTACTACATGTGTGATCTGAAAACCCTGCTTGGTTCTGAGCTGCGTC

TATTGAATTGGTAAAGTAATACCAATGGCTTTTTATCATTTCCTTCTTCC

CTTTAAGTTTCACTTGAAATTTTAAAAATCATGGTTATTTTTATCGTTGG

GATCTTTCTGTCTTCTGGGTTCCATTTTTTAAATGTTTAAAAATATGTTG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatACATGGTAG

TTCAGTTCTTAACCAATGACTTGGGGATGATGCAAACAATTACTGTCGTT

GGGATTTAGAGTGTATTAGTCACGCATGTATGGGGAAGTAGTCTCGGGTA

TGCTGTTGTGAAATTGAAACTGTAAAAGTAGATGGTTGAAAGTACTGGTA

TGTTGCTCTGTATGGTAAGAACTAATTCTGTTACGTCATGTACATAATTA

CTAATCACTTTTCTTCCCCTTTACAGCACAAATAAAGTTTGAGTTCTAAA

CTCATTAGAATTGTTGTATTGCTATGTTACATTTCTCGACCCCTATCACA

TTGCCTTCATAACGACTTTGGATGTATCTTCATATTGTAGATTTAGGTCT

AGATTTGCTAGCTCCAAGTAATTAAGGCCATGTAGGAGAGCATGGTAACC

ACAGATAGAACTGGTATTATCCCAAGTGGTCTGCAGACTGC

(SEQ ID NO: 242)

pARBI-638:
TTACAGCACAAATAAAGTTTGAGTTCTAAACTCATTAGAATTGTTGTATT
2541

chr11_2_
GCTATGTTACATTTCTCGACCCCTATCACATTGCCTTCATAACGACTTTG

Exogenous_97
GATGTATCTTCATATTGTAGATTTAGGTCTAGATTTGCTAGCTCCAAGTA

ATTAAGGCCATGTAGGAGAGCATGGTAACCACAGATAGAACTGGTATTAT

CCCAAGTGGTCTGCAGACTGCTGAGTGGGGATGGGATCTGCTCTCTGTTG

AGAGTTGGTAATCATTGGTTTGAAATGTGATGAAACCACTCAAGCCAATG

AAGGTGGGTGTGTAGGTGGGGAGTACTTTGCCATAATATTTTAAAACATT

ACCTGGTTAGAGTTCTAAGTGGTACTTATTTTTGTTTGGTTAGGGGAAAG

CCTGAATAAAAACAGAAATGGACACATAATATGCATATTCCATAGTCTTT

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatGGGAGGCTG

GAATGTGCCTGGGATTTGGGTCTAAGTGTATGCGTAATTCTTACCTCACT

AAAGAATTTGCCTTGTTTTTTTCCTTTTGGTGAGTGACTAAAACGTCTGG

GCTTCCCTGTGTGCGTGCTACAGTAAGCAAGCAGAGGCTGTGCAAAGGTG

TGAGCAGGATCACGTGGAATCTGGAGGATACATCTTGGCTTGCAAACTGC

CTCTGTCTCCTGGGTGGGACTGTTCTGTCCTTGCACTGCTGTTCTGTGTT

ACCTCTTGGGGTGTAAGGTTTTGCTTACAGGAGACAAACTTTGGGCGTAG

AATGGAAGCCACTGCCAGCCTCTGTGCTGAGAAGGAAGGTGCTTGTTTCA

AAGGGAGCAGCAAGGGAGGCTTGTTCTACTCACCTGGGCCTGTTTGCCTG

AGAAGGGGAGATAAGGGCTGAACTGGGACTAGCCAGGGGGA

(SEQ ID NO: 243)

pARBI-639:
TGGGGCTTTGGGGAATTTAGTGCGTGGGTGAGCCAAGAAAATACTAATTA
2541

chr11_3_
ATAATAGTAAGTTGTTAGTGTTGGTTAAGTTGTTGCTTGGAAGTGAGAAG

Exogenous_98
TTGCTTAGAAACTTTCCAAAGTGCTTAGAACTTTAAGTGCAAACAGACAA

ACTAACAAACAAAAATTGTTTTGCTTTGCTACAAGGTGGGGAAGACTGAA

GAAGTGTTAACTGAAAACAGGTGACACAGAGTCACCAGTTTTCCGAGAAC

CAAAGGGAGGGGTGTGTGATGCCATCTCACAGGCAGGGGAAATGTCTTTA

CCAGCTTCCTCCTGGTGGCCAAGACAGCCTGTTTCAGAGGGTTGTTTTGT

TTGGGGTGTGGGTGTTATCAAGTGAATTAGTCACTTGAAAGATGGGCGTC

AGACTTGCATACGCAGCAGATCAGCATCCTTCGCTGCCCCTTAGCAACTT

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatAGGTGGTTG

ATTTGAAACTGTGAAGGTGTGATTTTTTCAGGAGCTGGAAGTCTTAGAAA

AGCCTTGTAAATGCCTATATTGTGGGCTTTTAACGTATTTAAGGGACCAC

TTAAGACGAGATTAGATGGGCTCTTCTGGATTTGTTCCTCATTTGTCACA

GGTGTCTTGTGATTGAAAATCATGAGCGAAGTGAAATTGCATTGAATTTC

AAGGGAATTTAGTATGTAAATCGTGCCTTAGAAACACATCTGTTGTCTTT

TCTGTGTTTGGTCGATATTAATAATGGCAAAATTTTTGCCTATCTAGTAT

CTTCAAATTGTAGTCTTTGTAACAACCAAATAACCTTTTGTGGTCACTGT

AAAATTAATATTTGGTAGACAGAATCCATGTACCTTTGCTAAGGTTAGAA

TGAATAATTTATTGTATTTTTAATTTGAATGTTTGTGCTTT

(SEQ ID NO: 244)

pARBI-640:
CGACCAACCCATCAAACTCCCCGCCCCCAGCACTTTTATTTCTCCTCTTT
2541

chr11_1_
AGGAAGTACACTTCAGTATCTTTGGCACAGTGCATGAGCACGACTAAAGT

Exogenous_94
AAAACATCGCAGAAAACATAGCTTTAGTCTACCCTTCGTGTCCTAAAAGG

AAAACCAGTAGCTTCCCAGGCCACCGGAAGGGCAACACATGTCCTCTGCA

GTTTCTGCACACGGGAAGGTAAAGACAGAGAGAGGACCTACTCCTCAACA

CAGAAACATTTCAAAATCTTTCCTCGCCTGCAACCCAAGCTGAAGTCATT

CTCCCCAGAAATAACAAAAGTTGGAAGAGAAGCCGGAGACAGGATAGGTG

CAGGAAGCCCACACTTTGAGGGCAGCACTCAGACACCCTCTCCTGTGTGC

AGGACGTGCCGAATGTTCAGGTGCAATGAGAATGAGCCATGCTTGGCTTA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatCGAGGGCAA

TCTGGCCCATCAAGTGGCCTTCGCCTCTGGGAGTAACAAAAATGCACTTC

AAAATAGCTTCTGTAATCAAGCTGCATGGGTGGAGTACTCCCCAGCTGAC

TCCAGGAAGTTCTCTATCCAAAGCTATTCATTAGGCCAGAGCTGTGCAAA

TAATTAGTCACCCACTTGCTCCATAACCCTCCATGACAGCCCAGGCATTG

AGTCCAGGTGGGACCATCAAGCCATGCTCTGGTGGCTCATGCATTATCAT

AGAAATGGGAGGCTTTATTTATTTTACTAAAAAGAACAAAAACAACAGAC

TGCTGTCCTTTAGACAATAGGATCACGTCATCTGAGCCCTCTGTGCCCCA

GGTGACAAGCCCAGCCCCAAGTTCTCTTTCCTCAGCCTCCCCACACATGT

TCTGGAGGAGATGGGCCCAGCAGGCTGCTCTGAGGCCTGGC

(SEQ ID NO: 245)

pARBI-641:
TCACAGAATCTTGTTTGAGCTAACAACCAGTTATTCTACCCAAAGTAAAG
2541

chr11_2_
AGTAACTTAAATTTTCCCATTGTTCTTCCAGGCTGGAAGATGTAAGAAAC

Exogenous_96
ACACACAGTATAGTGTAGGTTTCCTCCATAGTTAAGTACCCCAGAGCTAG

GCTGAAATCCAGTGTTGGATTGTTTCCAACTTATAGTAGGGAACCGCCAA

TGACATGAAAGAGCATTACCTTACCGGACTGATTCATATTCTACTTCCAG

TCATAGTACAAATGATCACATGTCCACACCCACATGTGCTCTGATAAGTA

GTCAATTGAGAGGAGTGAGTCAGGGAGCCGTAACTTTGCAGCCAACCTGC

CAAGAAGAACTGATGCTTTTAGAAATTCAGCAGCTTTCATTGGCATAGAA

GTTTCAGCCTTATAGGCCCAGGGTTTCTCTGAGGCAGAGGCAAACCCTGT

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatTGTTATGTT

GTTATCTCAGGATTCTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTT

GCCCAGGCTGGAGTGCAGTGGCACAATCTCGGCTCACTGCAAGCTCCGCC

TCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACT

ACAGGCGCCCGCCACCACGCCTTTCTAAATTTTGTATTTTTAGTAGAGAC

GGGATTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGAT

CCGCCGCCCTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGC

GCCCAGCCTATCTCAGGATTCTTAATGTAAAAACAGTTCAGTATGGAAAG

CGTACTTATGACAGAGCTGTTGCAGAATGTGAAATCACCCATGTGCCTAA

GTGTCTCCCTACTACCTGGAACACTAGACCACATGCAGCAG

(SEQ ID NO: 246)

pARBI-642:
CAGCCCTGAACTCAGCCTTCACGGCCCTCCCTAAACACATGGGCCAGCCA
2541

chr11_3_
CAGGGAAGAAAAAAATGCCCTGTAGCACAGGAATCTAAAACATTGCTGTT

Exogenous_95
GTTCTAGTTAATAAAAGGACTTAGAGATTGAAAAGAAGTACCATCTGTAT

GGCTGGCAACAGACAGCATGATTTTGATGACTGACTCTGGGGAGATCTGA

GAAAACAGTACATAATATGTCCTTACCTCTGCTCCATCATTCATGACCCA

AGCTCCTGCCCTGTCTTCTCAGGAAGATTCTTACAGTAACTCCAGTTTGG

AATTCCCCTTTCATATTTGAAATAACAACAGTAATAGTGACCACTAATGC

TTACCGAGTGTCCACTCTGTGCCAAGCATCGTGTTTTTATCATCTTTTTT

GTTAGGCACTGTACATGGATTAATACAATTACAACCCACCACAACCCCAT

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatGAGATAAGT

ACTTGTACTATCCTCATTTTATGGGTGATGATACAAGAAACAGAAAGGTT

CAGCAACATGCCTAAAGCCACACAGCTACTATGAGGCAAAGTCTAGGTTT

GAACTCAGAAATTCTGACTTCAGACTCACTTATCTTATTATACTTCACTT

AGTATCTCCCATTAATTAATTCATTCATTCTTCCTTTTATTTGTTAATTC

ACCAAATATTCTGGGAAGCTACTTGTCTAGACACTGTATGAAAAATGAGA

ATGGATACAAAGCAACCTCAGACATGAACTCAAGGTCCTTACAAGCTTAA

ACGTATATGATACATTTCCAAATAGCAATACTATGAGGACAGCTGATACT

CACAACATAAGTCTTGGTGGTCACAGGAGATCTATCATAGGATTTCACGA

AGAACCTGACACTGAAAACCAGAACTTGAGGGAAATAAAAC

(SEQ ID NO: 247)

pARBI-643:
GTGTCCATCCTGCATGTCTCAAGTCACAATCCTCCAGATATTCAACCAAA
2541

chr15_1_
GTGCTTGATTCTGTTGGCACAAGGACCATGAAATCTTCAGTAGCTAAGGA

Exogenous_100
GACTCTTTGACAAATAGATTTATTGCATATGATGTAAAAGGGTCTCATTC

AGAGAACTACACATTTACTACACATTTACTAGCTGTTAGATGTGAGAAAT

TGAAGCTTTGAGAATTGTCATTTTGTAAGCACGCTGTAATAATTGTGTTC

TCTACAAAAATGGAGAAATACTTAATCTTTGCAGGTTTTTATTAGCTTCG

AAAAAGGGAATACAAATATTTTGATACCTGACTTTATTTTAAAGATACTG

GCAAGCAAGGAAAGATACTCAGTTTGCTAAATTATAGCATAGATTTGAAA

GACGGAAATTTTTTTTTGTTATTTTGATTCTTTCTGATTCAGAACCTGCG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatTGAGTTTCC

ATTCCTGGGATAGAGAGCCCTGCCAAAGCCAACTCAGTCTCCTGTTATTG

CAGAAATTTAAAGGTTACTTGAGCTGATTGATACCAATTAAAATAAAAGC

ATCTACTGCCATTTTATTAAACGCCCTATTTAATCTCCACATCCCAAGTT

CATTCTCTCTCTCTTTTAAGGCTATACATGGGCCTCAACATTCTCTCTTC

TTCAGTATCAGCTGTCCTCATCCCTATTCAAAGTCAGAATGACTTGGAAT

CTATTCAGGGCTGCTACTTAATTGGATGAAGAAAGTACTCTGTTGCATGC

TAACCTCCCAGATTTGAATTAGAACCAAGGTCCTGAATCTACACAAGACC

TTTTTCCCTTTCCTTTCTGCATTTATTTCTTTTTTTTCTACATCTTTCTT

TTTGAATTTTTTTTTTTTTTTTTTTCTGAGATAGAGTCTTG

(SEQ ID NO: 248)

pARBI-644:
ATCATCAAAATCTTCATTTATACAAATCACGGGTATTAGAAATAAAATCA
2541

chr15_2_
GGTATTGTGTACAGTCAGATCCCAGGTTTACACAAACTAGAGGTTTCAAT

Exogenous_101
TAAGTTTCCTTCATTTTATAAAACCATGACACAAGCTGTAAATAAAGGAG

CTCTGGCTTTAGGCCTTCTTCTGTTTATAGACAGTAAATTTTAATCCTCT

GTCCCTGCAGACCAACTCAAAGCAGTAACCTTGGCTACCGTTGCCGCAGA

AGAAACACACCCTGCAGATTTCCAGTTCTATATTCAGTCTTAGAAAATTG

GTCATGTTGAAAGGGAAAAAACAATTTTACTTTGCCTCAGTTATTGACAC

CAAGAAGCACTCCTCAGCCTGTTCAGAGGGGAAACAATGAGTCATTCATG

CTGTCAGCCCAGGTGGTGCATGAATTCCAGACAGAGGCCGCTGAATTAAC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatCCGTGGAGG

CGTCTCTCTGAGCAGAGCCCGCAATGCGCCTGCTTGGGGCTCCCTGCAGC

CTCTGGGGGAGGCAGGGCGGCCCAGAGCAGGCCTGTGCTGGAAAGGAACG

CGAAGCCCTGTAACCAAGCCTGTACCTCTGCAGTGCTAGTCCCAAGGGGC

CTCCGAGCTGTTTGTCACCATGTGATTGGCTCAGGAGAGGGGTGGAGAAA

TGAAAACACTCTGCCCAGGATATATTTAGTTGAAGTGCAGCTGGGGAAGT

GCTTAAACAAGGGAGCTTTTGTCCTTATGTTGAAGTGTTTTTCTTAACTC

CTCAAGGGTGAAAAACTTGAGCCACGTACTGATCCCATTCCCCCCCACCA

CCCCCAATATATTTTCTCTTCTTTAGGAAATGCTCTTATTCTGAAACTTT

AGAATTTTCTAGGGTTTGTTGCATAAGAGGAAACTGAATAA

(SEQ ID NO: 249)

pARBI-645:
CTTTCCTTTCTGCATTTATTTCTTTTTTTTCTACATCTTTCTTTTTGAAT
2541

chr15_3_
TTTTTTTTTTTTTTTTTTCTGAGATAGAGTCTTGCTCTGTCGCCAGGCTG

Exogenous_102
GAGTGCAGTGGTGTGATCTTGGCTCACTGCAGTCTCCAACTCTGGTTCAA

GCAATTCTCCTGCCTCAGCCTCCGGGTAGCTGGGACTACAGGCATACACC

ACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCAT

AGTGGCCAGGATGGTCTCCATCTCTTGACCTCGTGACCTGACCCCCTCGG

CCTCCCAAAGTGCTGAGATTACAGGCATGAGCCACCGCGCCCGGCCTCTT

TTTGAATTTTTTTAAAAAAACACCTAAAGTTTAGGAAAGTATAAGAGGCC

AAAGAAACAAGAGTTCAAAGAAACAAGAGTGTTATACACGCACACTTGCA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatGAAAGGTAGT

AAAATATCTGTATAGTTCTGGCTGTCAAGCTTTTGGACTGAGATATGCGT

AAGCAAGGCAAAAAGATCCCATAGTCCAGGAATATCAACCAGTCCAGTTT

CCCAAGGAAACTAAAAGTAACTGAAAATGAGAAGGGTGCCATATAGGAAA

ATTGAAGGTGGGGCATAATTATTAATACACTGCTTTGGAAATGCTGGTAT

GGAAGATTCATATATGGACTTCAAAGCATACATGTCTTATACTTAGCTAT

GGGAAAATTATCATCAAAATCTTCATTTATACAAATCACGGGTATTAGAA

ATAAAATCAGGTATTGTGTACAGTCAGATCCCAGGTTTACACAAACTAGA

GGTTTCAATTAAGTTTCCTTCATTTTATAAAACCATGACACAAGCTGTAA

ATAAAGGAGCTCTGGCTTTAGGCCTTCTTCTGTTTATAGA

(SEQ ID NO: 250)

pARBI-646:
TGTCTTCACGGCACGGCCCCCGCTTCACCAGCTGCACTGTTTGATGAGCT
2541

chr16_1_
TTGCAGGTCCCAGATCTTATAAGCTCATGGTGATTGATCCAAATGATGCA

Exogenous_103
GAGGTCGGCCTAAAGTTAGAAGTGGGCCCCTCTCTGCCCCAAGACAGCCC

TTCACCCCAATTCCATTCCCACAGTTTGGGCATCCACCCAGGCTGCCAAG

CCAAGCGGGGGCTGCCCGGGTTAGCAGGGACCTGGCCATGGGCCTCCTCA

GCTAGGGGCCGCCTCTCTGAGGAGTGGGTGCCCCGCCCCTCCGTGGGCCG

CCTGGTTTCTCTTATTGGCAGCGTCTGTAGTCCCCTGGCTCTGTCACCCG

CAGCTATTCTAGGCCTCTGGTTCCTTTCACTTTCTGCTCTGCGTCTTCCT

GCCTCGGTGGTTCCCCACCATCCAGCCTGAGACCTCCCCGTTGCCCGCCC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggggggggggcaggacagcaagggggaggattgggaagacaatagcag

gcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGTG

CCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGGG

GGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAAA

CTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGGG

GAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAAC

GGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTCC

TTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGTC

GCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGTC

TAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCCC

TTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTGC

TTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAGA

TCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccaccA

TGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGTC

GAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGGG

CGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACCA

CCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTAC

GGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACTT

CTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTCT

TCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGGC

GACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGGA

CGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAACG

TCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAAG

ATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACCA

GCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCACT

ACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGAT

CACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCAT

GGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaat

aaagcaatagcatcacaaatttcacaaataaagcatttttttcactgcat

tctagttgtggtttgtccaaactcatcaatgtatcttatTGGGTTTCTGT

CTGCTCCTCTCCGTGGTGGCCGGCCCTGGCTCTGCCCCAAAGCCATGGAG

AAGGCCAAATGCAGGCTGTAGAAAGGTCTGGGATCAGATCCCCCCATCCT

TCCATGGCCACGTGACCGGGCCCGCCTCTTCCCTCTGAGCCTCACATCCT

CATCTGAAGAGGGAATGCTGCTCATGCCCACCTTGCGGGGATGTGGGGAG

GGGGTGCTGCCAGTGGAGACTCCCAGGGGACCCTCCAGGAGTCTCATCCT

GACTCGAGACTGGGCACCTGGTGGGGGCACAGGCCCCCTCTCCCGCCATG

GGACCGCCACATCCAGGCTCTCGTGGGTTGAGATGCTGAGGAAAGGAAAG

AACAAAACCTGCTGGAGGAGCAGCGAACACGGCCCTCAGCTGGGTGACCT

TGGGCAAGTCACTTCCCCTCTCTGGGCCTCAGTTTCCAT

(SEQ ID

NO: 251)

pARBI-647:
CTGAAGAGGGAATGCTGCTCATGCCCACCTTGCGGGGATGTGGGGAGGGG
2541

chr16_2_
GTGCTGCCAGTGGAGACTCCCAGGGGACCCTCCAGGAGTCTCATCCTGAC

Exogenous_104
TCGAGACTGGGCACCTGGTGGGGGCACAGGCCCCCTCTCCCGCCATGGGA

CCGCCACATCCAGGCTCTCGTGGGTTGAGATGCTGAGGAAAGGAAAGAAC

AAAACCTGCTGGAGGAGCAGCGAACACGGCCCTCAGCTGGGTGACCTTGG

GCAAGTCACTTCCCCTCTCTGGGCCTCAGTTTCCATATCTGTGAATGAGG

CAGCTGGACTGAAGAATAGAGAGTCACAAAGCAGAGTGACACAAACTGGG

CTACAGGAAACCCTGGAGGCCCTCGACCCAGGCTGGGGCCGGGGATGGTT

CTGCAAAGCCTCTTGGGAGAGGGTTGCCTGAGCTGAGTCTCCAAACAGAA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatCAGTGGCCT

TAAGTCACGGGAGATGAGCCAGAGCAGTCCAGAGGGCACGGTCAGCACAT

GCTAAGGTCCTGGGGCACAGAGTACAGGGCTTGAGAAGGGTTCCTCTTGC

TCCATGTGACTTTCATCATCCAACAGCCTGTGGTGGCACTTGCCTGTATC

CCAGCTATCTAGGAGGCTGAGGTGGGAGGATTGCTTGAGTCTGAGAGGTC

GGGCTTGTTCTCCCGGTGTTGGCAGAGTCCAGAGGGAGCAAGTGGAAGCC

ACAGGTGTCTTGAGGCCTAGGCTGAGATCTAGCACATCACCGCGTCACTT

CATCCCTTCATTTCATCCTATTGGCCAAAGCAGCCCAATTCTAGGGATGG

GGATCTAGACTCAACTTCTTGATGGGAGAAGTAGCAAAGTCACACTGCCA

AGGGCAGGGACACAGGGAGGGATGAAGAGTTAGGAATGGTT

(SEQ ID NO: 252)

pARBI-648:
AAGCCACCTCCCTGCTCTGTTGCTGGCTCTCCTTGAAGACAAGTGTTTTT
2541

chr16_3_
CAATTAACCAAAGCGGTGCATGGCAATGTGATAGGGGAATGAAACACAGC

Exogenous_105
AACAGAATCAATGCCCCACGCTGGGCAATAGCCGACTTTCTGTTCGCTCC

CATCCCTTCCTTCCCTCCCCGCCTCCTTCCCCTGCTCCTTCCATTCCACA

AACATTTATTGAGCACCCGCTGTGTGCCAGCCACTGTTCTAGGCCCTGAA

GACACAGAAGTGAACAAAAAAAAAGAGTCCCTGTGCACATCCTGGAGGGA

CTTTCCCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTATACAGTGTA

TGGAGACAGTGGATAATAAAAGCTGTTTATGAGGCACTTTCTCTGAGCTG

TTCCATGTGCTTCACTTATACTCATTCAGCTAATCCTCAGGACACCCCCG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatTGAAGTCAG

TGATATTAGTCACAGAGGCCCAGAGAAGTGAAGTGACTTGCCCAAGGTCA

CACAGCCAGCAAGAGGCCAAGCCCGGATTGAACCCCAGCCGCCTGGCTCT

GGAGCCTGCAGCATAACCACAGCAGGGAACTGCCACCGGAGACAGACATC

GACAGCCACTAGGAGATGTTAACCAACAGGCTTGTCTTCACGGCACGGCC

CCCGCTTCACCAGCTGCACTGTTTGATGAGCTTTGCAGGTCCCAGATCTT

ATAAGCTCATGGTGATTGATCCAAATGATGCAGAGGTCGGCCTAAAGTTA

GAAGTGGGCCCCTCTCTGCCCCAAGACAGCCCTTCACCCCAATTCCATTC

CCACAGTTTGGGCATCCACCCAGGCTGCCAAGCCAAGCGGGGGCTGCCCG

GGTTAGCAGGGACCTGGCCATGGGCCTCCTCAGCTAGGGGC

(SEQ ID NO: 253)

pARBI-649:
GGGGGCGGCCGCACGGCTAGAGCGGAGACCCCGCGCCCCCTCCGCCCGCG
2541

EDF1_1_
TGGCCCGGCCGGGGTGCGGGGCCCGGGGAGGCACGGGGGCTGCGCGTCGG

Exogenous_25
GGCGCAGCCGCCGCCCGCGTGTGCTCGGAGGCCGCGGGGCCCGGGCTCCG

GGGTCCTCCCGACCTGCAGCCCCAGCGGCTACCGCGCCTCGCCAGGCCAG

GCCAGGCCCCGACGTCGCCTTCCCTACGTCGCCGGCGCCCGGCCACGACG

TCCCTCAGACGAGCCGAACGCCGAATGGCCCCGAGCACGGGAAGTGCCCG

CCCCCCGCGTGCAGCCAGCCAATGGGACGCCGAAAGCGGGGAGGTGCCGA

GGGGACGTAGCGTCGCCGCGCCAGGTCTCTAGCAGCTGCCGCTGAGCCGC

CGGACGGACGCTCGTCTTCGCCCGCCATGGCCGAGAGCGACTGGGACACG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatGTGACGGTG

CTGCGCAAGAAGGGCCCTACGGCCGCCCAGGCCAAATCCAAGCAGGTGCT

TTGCTGACTGAGGAGCGGCCGGGCCGGGCGGGGCGGACGCTgggccgggg

ccacggaccgtggggcagggggctcggggaagggcaggcggggcctggga

cagggcgcaggggacggggacaaggctggGGTGCCGGGGGCAGGACGGGG

TTCGAAGGGCGGGGCGAATCGCAGGGGTAGGAGGACCGGGCCAGGACagg

ggtgggaaggtggggggcggacccaggaggggatggacggacccaggagg

cagggggCGGGCGACTGGAGGAGGAGAGGAGCAGGGAACCGGACGGGGCA

AGGGGCAGGCGATAGGGCCGGGACCAGTGCCAGGGTGGGGGGGGGAGGGG

ATAGGGGCAGGGACTGTTGGTGGGGACAGGTGTGAGGACAG

(SEQ ID NO: 254)

pARBI-650:
ACGGCTAGAGCGGAGACCCCGCGCCCCCTCCGCCCGCGTGGCCCGGCCGG
2541

EDF1_2_
GGTGCGGGGCCCGGGGAGGCACGGGGGCTGCGCGTCGGGGCGCAGCCGCC

Exogenous_26
GCCCGCGTGTGCTCGGAGGCCGCGGGGCCCGGGCTCCGGGGTCCTCCCGA

CCTGCAGCCCCAGCGGCTACCGCGCCTCGCCAGGCCAGGCCAGGCCCCGA

CGTCGCCTTCCCTACGTCGCCGGCGCCCGGCCACGACGTCCCTCAGACGA

GCCGAACGCCGAATGGCCCCGAGCACGGGAAGTGCCCGCCCCCCGCGTGC

AGCCAGCCAATGGGACGCCGAAAGCGGGGAGGTGCCGAGGGGACGTAGCG

TCGCCGCGCCAGGTCTCTAGCAGCTGCCGCTGAGCCGCCGGACGGACGCT

CGTCTTCGCCCGCCATGGCCGAGAGCGACTGGGACACGGTGACGGTGCTG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatCGCAAGAAGG

GCCCTACGGCCGCCCAGGCCAAATCCAAGCAGGTGCTTTGCTGACTGAGG

AGCGGCCGGGCCGGGCGGGGCGGACGCTgggccggggccacggaccgtgg

ggcagggggctcggggaagggcaggcggggcctgggacagggcgcagggg

acggggacaaggctggGGTGCCGGGGGCAGGACGGGGTTCGAAGGGCGGG

GCGAATCGCAGGGGTAGGAGGACCGGGCCAGGACaggggtgggaaggtgg

ggggcggacccaggaggggatggacggacccaggaggcagggggCGGGCG

ACTGGAGGAGGAGAGGAGCAGGGAACCGGACGGGGCAAGGGGCAGGCGAT

AGGGCCGGGACCAGTGCCAGGGTGGGGCGGGGAGGGGATAGGGGCAGGGA

CTGTTGGTGGGGACAGGTGTGAGGACAGAGGCAGGAGGTG

(SEQ ID NO: 255)

pARBI-651:
CCCTGGAGTCGGTGTGAGGCAAAAGCAGAGGAGAGGATTTGGAATTAACC
2541

EDF1_3_
TGAAGAAAAACCATTTCAAAGCGGTAACCAGACCCCAGAGGCTGCCTGAA

Exogenous_27
CTCAAGGGGACATGGGAACCCAGGCTGTCCCAAGTTCACACACCTCAGGT

CGTGGACTTCCAGAGTTTTCTCTCAGTTATGAGGACAGGCAGCTGTACTC

ATGCCAACCAGAGCTGCTCTGGGAAGATGGCTGCCTCCCAGGGCTCCGGC

CAGCACCGGTGCAGGCAGGCACTCAGCTGACAACGTCCCCGGGGGCGCCG

CACACACCACACCCACCAGCACATGGACCCCACAGCACAGCCTCATGTTG

CAAGCGGAAACACAAGTACCTACATTTCTTGGAAGTCTCCACATCTTCTC

CTCGTCTCTGTGCCGCTAAGATAGCCTAGAAAATTAGAAAACATCAGTGG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatTTTCTAAAG

AGAAGATGTGCTTTATACACATCAGCTCCACTAGGACTGCTGCAAAACCA

GGCGCGAAGCGTCGCCTGAGAACAGCAGCTTCTAGGGCCCCTGGGGTACG

CACCCACACGCAGCTGGGTTTTGTGCGAGAGGCAGTGAGAGCCGGGCTGA

CCTGGCTTCCCGAGGCATTCCCTGCAGGGGAACCAGGGGGGTGGAGCCCA

CCCTCCCCGTGCTATCTGAACACCGGCCATCCCCCTCCCCAAACCCACAA

CCCCAGGAGTGAGAGCCCCGGCGCAGCCTCACCGTGGCCAGGTCCTTCTG

CGTAAGCCCCTTGCTCTGCCGACCTTGCTGGATCACCTTGCCCACCTCCA

GGGTCACCCTGTCATGGTGCAGCTCCTCTGTCTCCCGGTCCAGCTTGGCC

GTGTTCTTGGTAATAGAATGTTGTTTGTTCTGGCCAGCAGC

(SEQ ID NO: 256)

pARBI-652:
CTCTTGCTTCAACAGTGTTTGGACGGAACAGATCCGGGGACTCTCTTCCA
2541

FTL_1_
GCCTCCGACCGCCCTCCGATTTCCTCTCCGCTTGCAACCTCCGGGACCAT

Exogenous_2830
CTTCTCGGCCATCTCCTGCTTCTGGGACCTGCCAGCACCGTTTTTGTGGT

TAGCTCCTTCTTGCCAACCAACCATGAGCTCCCAGATTCGTCAGAATTAT

TCCACCGACGTGGAGGCAGCCGTCAACAGCCTGGTCAATTTGTACCTGCA

GGCCTCCTACACCTACCTCTCTCTGGTGAGTCCCCAGGACGCCCCTGGCC

CTAATTTCCTCCAGCTGCGCACCTCCGGCCCTCACTGCACGCGCCAGCCT

TCTTTGTGCGGTCGGGTAAACAGAGGGCGGAGTCCCCTTGGCCTCGCCTC

CCGCTAACCATTGTTGCCTCCATCTCTTCCCGTAGGGCTTCTATTTCGAC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatCGCGATGATG

TGGCTCTGGAAGGCGTGAGCCACTTCTTCCGCGAATTGGCCGAGGAGAAG

CGCGAGGGCTACGAGCGTCTCCTGAAGATGCAAAACCAGCGTGGCGGCCG

CGCTCTCTTCCAGGACATCAAGGTAACTAGTGTGTGGGTAATGGACTACA

TCTCCCAGCAGGCCGTGCGCGCGAGGAGCCTTGATTTGAGGGCGTAGGTG

TCGCGTGGGCTTCTGGGAGATTGAGTTCGGTCTTGTGAGCCCTCTTAACC

GCTGGAAATAGAGGCGCACCTCGTGCAGTGCCCACAACACGCGGCAGTCC

ACACCGCTGCGTGGTCTTAGGGACGTATAGCTGTAAGAGCTAGGACAGGG

TGCGGAGAGTGATAAATACAAGCTGTCACATGTCTTTGTGGCCTGGGCCT

CTGACCCCCAACGACTCTTGGGAAATGTAGGTTTAGTTCT

(SEQ ID NO: 257)

pARBI-653:
TGGGGCGGGGGGCTGAGACTCCTATGTGCTCCGGATTGGTCAGGCACGGC
2541

FTL_2_
CTTCGGCCCCGCCTCCTGCCACCGCAGATTGGCCGCTAGCCCTCCCCGAG

Exogenous_29
CGCCCTGCCTCCGAGGGCCGGCGCACCATAAAAGAAGCCGCCCTAGCCAC

GTCCCCTCGCAGTTCGGCGGTCCCGCGGGTCTGTCTCTTGCTTCAACAGT

GTTTGGACGGAACAGATCCGGGGACTCTCTTCCAGCCTCCGACCGCCCTC

CGATTTCCTCTCCGCTTGCAACCTCCGGGACCATCTTCTCGGCCATCTCC

TGCTTCTGGGACCTGCCAGCACCGTTTTTGTGGTTAGCTCCTTCTTGCCA

ACCAACCATGAGCTCCCAGATTCGTCAGAATTATTCCACCGACGTGGAGG

CAGCCGTCAACAGCCTGGTCAATTTGTACCTGCAGGCCTCCTACACCTAC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatCTCTCTCTG

GTGAGTCCCCAGGACGCCCCTGGCCCTAATTTCCTCCAGCTGCGCACCTC

CGGCCCTCACTGCACGCGCCAGCCTTCTTTGTGCGGTCGGGTAAACAGAG

GGCGGAGTCCCCTTGGCCTCGCCTCCCGCTAACCATTGTTGCCTCCATCT

CTTCCCGTAGGGCTTCTATTTCGACCGCGATGATGTGGCTCTGGAAGGCG

TGAGCCACTTCTTCCGCGAATTGGCCGAGGAGAAGCGCGAGGGCTACGAG

CGTCTCCTGAAGATGCAAAACCAGCGTGGCGGCCGCGCTCTCTTCCAGGA

CATCAAGGTAACTAGTGTGTGGGTAATGGACTACATCTCCCAGCAGGCCG

TGCGCGCGAGGAGCCTTGATTTGAGGGCGTAGGTGTCGCGTGGGCTTCTG

GGAGATTGAGTTCGGTCTTGTGAGCCCTCTTAACCGCTGGA

(SEQ ID NO: 258)

pARBI-654:
CTTTGCATAGTTTATCCTATTAGTAATCTATTCTGTCTTTGGAATATGTT
2541

PTEN_1_
TTGTGATGATGAAATAAATACTATAAATAGTATTATTCCTTTTGCATTGA

Exogenous_31
GAGTCCTGACGAAATGTCCATGTGACAGTTCATTTTGGGTTTAGCTCTAC

CTCTAATATGTGACCTATGCTACCAGTCCGTATAGCGTAAATTCCCAGAA

TATATCCTCCTGAATAAAATGGGGGAAAATAATACCTGGCTTCCTTAATG

ATTATATTTAAGACTTATCAAGAGACTATTTTCTATTTAACAATTAGAAA

GTTAAGCAATACATTATTTTTCTCTGGAATCCAGTGTTTCTTTTAAATAC

CTGTTAAGTTTGTATGCAACATTTCTAAAGTTACCTACTTGTTAATTAAA

AATTCAAGAGTTTTTTTTTCTTATTCTGAGGTTATCTTTTTACCACAGTT

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCG

CACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGA

AGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGAC

TTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAA

CAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGG

TGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCC

GACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCC

CGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACG

AGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATC

ACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagcttataa

tggttacaaataaagcaatagcatcacaaatttcacaaataaagcatttt

tttcactgcattctagttgtggtttgtccaaactcatcaatgtatcttat

GCACAATATCCTTTTGAAGACCATAACCCACCACAGCTAGAACTTATCAA

ACCCTTTTGTGAAGATCTTGACCAATGGCTAAGTGAAGATGACAATCATG

TTGCAGCAATTCACTGTAAAGCTGGAAAGGGACGAACTGGTGTAATGATA

TGTGCATATTTATTACATCGGGGCAAATTTTTAAAGGCACAAGAGGCCCT

AGATTTCTATGGGGAAGTAAGGACCAGAGACAAAAAGGTAAGTTATTTTT

TGATGTTTTTCCTTTCCTCTTCCTGGATCTGAGAATTTATTGGAAAACAG

ATTTTGGGTTTCTTTTTTTCCTTCAGTTTTATTGAGGTGTAATTGACAAG

TAAAAATTATATATAAATACAATGTATAATATGATGTTTTGATGTATGTG

TATATACATTGTGAAATGATTACTACAGTCAAACTACTTAACATATTCAT

(SEQ ID NO: 259)

pARBI-655:
GCTACCAGTCCGTATAGCGTAAATTCCCAGAATATATCCTCCTGAATAAA
2541

PTEN_2_
ATGGGGGAAAATAATACCTGGCTTCCTTAATGATTATATTTAAGACTTAT

Exogenous_32
CAAGAGACTATTTTCTATTTAACAATTAGAAAGTTAAGCAATACATTATT

TTTCTCTGGAATCCAGTGTTTCTTTTAAATACCTGTTAAGTTTGTATGCA

ACATTTCTAAAGTTACCTACTTGTTAATTAAAAATTCAAGAGTTTTTTTT

TCTTATTCTGAGGTTATCTTTTTACCACAGTTGCACAATATCCTTTTGAA

GACCATAACCCACCACAGCTAGAACTTATCAAACCCTTTTGTGAAGATCT

TGACCAATGGCTAAGTGAAGATGACAATCATGTTGCAGCAATTCACTGTA

AAGCTGGAAAGGGACGAACTGGTGTAATGATATGTGCATATTTATTACAT

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatCGGGGCAAAT

TTTTAAAGGCACAAGAGGCCCTAGATTTCTATGGGGAAGTAAGGACCAGA

GACAAAAAGGTAAGTTATTTTTTGATGTTTTTCCTTTCCTCTTCCTGGAT

CTGAGAATTTATTGGAAAACAGATTTTGGGTTTCTTTTTTTCCTTCAGTT

TTATTGAGGTGTAATTGACAAGTAAAAATTATATATAAATACAATGTATA

ATATGATGTTTTGATGTATGTGTATATACATTGTGAAATGATTACTACAG

TCAAACTACTTAACATATTCATCACCTCACATAATTATTATTCTCCCCCC

AGGGTGAAAGCATTTAAGATCTACAAGCTACAATTTTCAATTATACAATG

TTATTATTAACTATAGTCACTATGCTGTCCAGTAGAGCTTCAGATCTTGT

TCATCTTGTGTTCCTCCCTCCCCACCCTCAGTCCCTGGAA

(SEQ ID NO: 260)

pARBI-656:
ATAAATAGTATTATTCCTTTTGCATTGAGAGTCCTGACGAAATGTCCATG
2541

PTEN_3_
TGACAGTTCATTTTGGGTTTAGCTCTACCTCTAATATGTGACCTATGCTA

Exogenous_33
CCAGTCCGTATAGCGTAAATTCCCAGAATATATCCTCCTGAATAAAATGG

GGGAAAATAATACCTGGCTTCCTTAATGATTATATTTAAGACTTATCAAG

AGACTATTTTCTATTTAACAATTAGAAAGTTAAGCAATACATTATTTTTC

TCTGGAATCCAGTGTTTCTTTTAAATACCTGTTAAGTTTGTATGCAACAT

TTCTAAAGTTACCTACTTGTTAATTAAAAATTCAAGAGTTTTTTTTTCTT

ATTCTGAGGTTATCTTTTTACCACAGTTGCACAATATCCTTTTGAAGACC

ATAACCCACCACAGCTAGAACTTATCAAACCCTTTTGTGAAGATCTTGAC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatCAATGGCTA

AGTGAAGATGACAATCATGTTGCAGCAATTCACTGTAAAGCTGGAAAGGG

ACGAACTGGTGTAATGATATGTGCATATTTATTACATCGGGGCAAATTTT

TAAAGGCACAAGAGGCCCTAGATTTCTATGGGGAAGTAAGGACCAGAGAC

AAAAAGGTAAGTTATTTTTTGATGTTTTTCCTTTCCTCTTCCTGGATCTG

AGAATTTATTGGAAAACAGATTTTGGGTTTCTTTTTTTCCTTCAGTTTTA

TTGAGGTGTAATTGACAAGTAAAAATTATATATAAATACAATGTATAATA

TGATGTTTTGATGTATGTGTATATACATTGTGAAATGATTACTACAGTCA

AACTACTTAACATATTCATCACCTCACATAATTATTATTCTCCCCCCAGG

GTGAAAGCATTTAAGATCTACAAGCTACAATTTTCAATTAT

(SEQ ID NO: 261)

pARBI-657:
TAGTGACGGTATCAAGAGCAGCATCCCAGGTTGACTTTCTTTGGGGCAGG
2541

PTPN2_1_
ACCTTGCTTGTGTCTTAACCCTTGGTTCCTACccaagtttgtctctctag

Exogenous_34
tcctcaactctgaaagccacttgatatcttacacaattccttttttgcct

gagaaaaaaaagtcagttttgatcatttacaaccaaaaatcctaactaac

acaGACCTGTTTTTGAAATCAGGTAGATTGGAAGTCTTGGTTTACTTCTT

ATAAGCCCGTCCGCTGTCTGTCTTGTAACATCCCAGGAGCAGACTTAACA

AGGCCTTCCTGGAGCCTTGCTCTTTCTGTCTGCTTCCCTCATCTGctctc

tctcctctctctTCACAGGGTCCACTTCCTAACACATGCTGCCATTTCTG

GCTTATGGTTTGGCAGCAGAAGACCAAAGCAGTTGTCATGCTGAACCGCt

gacgactgtgccttctagttgccagccatctgttgtttgcccctcccccg

tgccttccttgaccctggaaggtgccactcccactgtcctttcctaataa

aatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctggg

gggtggggtggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatATTGTGGAGA

AAGAATCGGTGAGTAATATTTAATATTTACAACTTAGTATACTGTATGTG

ATCATTAGCATATAAAGATTTTCATTTTGGGGCCAATATTCATTCCTTAG

TTTTGGCCTTTAATTGCTAAAGGCTAGCGGTCAAAGTGTTTCTGTCCGGA

AAAACTCATGTATCCTTTTCCTTTCTTAAGTATTTTTATAACAATTGCAG

ACCTTTCATCTCCAAGATAGAAATACAATGGAATAAATATGGACTAGCAG

TGACATATAGATCTTTGGAATCCCTAGGAATCCTTATTGACCTATTGTCA

ATAAGTCCTCTTCCAGCTTTAAGATCTTGTACTGTTCTACTTCAGATTTC

TTACTTTATTCTACATTTCATAATTGCTGGTTTTTAATGATGATGAAAAT

TTCCTAATCCACTTCTAATTAGATGTGGCAATGACATGCC

(SEQ ID NO: 262)

pARBI-658:
CAGAATTTGAATATGATGTGGCTGACCATAGATACCTCCATTGCATTAAT
2541

PTPN2_2_
TCTGCTTCATAAAGTGTTTGATGCTTGCTTGTAGGTGTTGAATAGAGCCT

Exogenous_35
AATTAGCAGTAAGTAAACAGATCTagagcacagactttggcatctgaagg

accttggttcaatgctgggactgccacttactagctatgggatctttggt

ggatttttaacctttgaaagcctttcatccctcacagatataatggggaa

gaaaatcgtttccattagtattgtgaggattaaatgattaattgatgtaa

acaatgtgctttccatagtacttggcatatcataagtgcttcatGTTATT

TTACGCTGGCTGGGAAGATAAGTTTTGCTGTGGAGAATTTAAGAGGGATA

TTAAAATATATTTTTGTTATTTTAAGGAAATTCGAAATGAGTCCCATGAC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatTATCCTCATA

GAGTGGCCAAGTTTCCAGAAAACAGAAATCGAAACAGATACAGAGATGTA

AGCCCATGTAAGTACTTGTGGGTTTGTGTGCATGTGTATTTTTTGGTTTG

TTTTAGGAGGCAGGATGTAGTGAAAAGGAGGGCTTGGGGTCAGTGTTGAT

AAATACAGTAATTTTTTTCCTATTTACGTAAGACACGTTCTTTAAGAATT

TAAAGGTGTAGAATAGTGGAAGGAAAAATAATTACCCATAATTATTTCAT

CCTTCAAACATAGGCACCATTATTTTGGTGTATTTCCCACAACCTGTTTT

TCTTATGCACAGTTTTCCTTTCTTTAAAATAATTGTAATTATAGATGTCT

ATATAATATCCATATGTATTTCCTTTTCATATCATTCCATCCCCTTTGTA

AGTTTTGCTTAAAATAGTTATTGGTGTAGTTTGGTTTTTT

(SEQ ID NO: 263)

pARBI-659:
ACCAGTTATCGTTTTGTAGGTAGACCAATCAATTCTTAGGTACCAAGAAT
2541

PTPN2_3_
CTGAATGATCCTTTTACTTTTAGGAAGGTAAGTACTTTATTCATTTAACT

Exogenous_36
ATGTTTACTCCTGGTCGATTTTTCAAGTCACAATGGCTAATGTGCTACAA

ACAGAAGTGCTTCCTTTCCAGCACTATAGTAATAAACAAGATTGCATTTT

ATACTCCTTACAAAAAAAGTAGAGAATAGTTTAGGATTTGTCTCAACTCT

ATTATGATGCTAATTCATTTTTCTTATTTCTTCTGTCTTTTTATAAATAC

CTAGAATATTAATATGAAGATAAAAACAGTAATTTTGAAATGACAGTTGT

GGTTTATCATTCTCTATTTTCAGATGATCACAGTCGTGTTAAACTGCAAA

ATGCTGAGAATGATTATATTAATGCCAGTTTAGTTGACATAGAAGAGGCA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatCAAAGGAGTT

ACATCTTAACACAGGCAAGTAATACGATACCACGCAAATGTCTGAAAATG

ATGTGTTTGTGCTTGTTCTGCTTTAAATCATAGGTAAAAGTATATCTTGA

CTTCTTTTGGAAATGAAATGGTATTTCAGTTTTTTTCTGACGATGTAATG

AATTATGGACATTATAAGGTTTTGAAGCTTTGAGTATTTAAGATAAAAGG

CAAGTTATTTTTGATATTACACGTTCTGTGAAGGAAAATTCTTAGGAAAT

GGCTTAGGCCAGTTCTTTGGCAGATTGTGTTCCTTACATTATATCTGACA

CAGAGTGCTGCTTATGCTTCTTAGTGTCTTCTTTTCTCTTCCCATACCCT

GTGGCAAAACCAGAGGCCCTGGACAGCTCTTCTGTAGCTCCCCCTGCCTC

GCATATATCTTCAGAGAGTACACCAAGCCCTGGATGGTGT

(SEQ ID NO: 264)

pARBI-660:
CCTGCTCAAGGGCCGAGGTGTCCACGGTAGCTTCCTGGCTCGGCCCAGTC
2541

PTPN6_1_
GCAAGAACCAGGGTGACTTCTCGCTCTCCGTCAGGTAGGTGGGCCCCCCG

Exogenous_37
CAACCCCGGGCATTTTGGCCACTCTCTTGTGCCATCCAGGCCCTGAACCA

CTCATTCCTGGTTCCCCGTGGCAGTGCTGACTCCCCGTCTGTTCCCTTGC

CCCCAACCCCCACACTCCCCATCCCTGTCTGTGCCCACCCATGCCCATGT

GTGCCCCCACCCAGGACCTCAGCCGATCCCTGCCCTCCTGCCTCTACTCC

TGCACCGACTGGCCTCACCGCCTGGTGCCCTGCAGGGTGGGGGATCAGGT

GACCCATATTCGGATCCAGAACTCAGGGGATTTCTATGACCTGTATGGAG

GGGAGAAGTTTGCGACTCTGACAGAGCTGGTGGAGTACTACACTCAGCAG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatCAGGGTGTC

CTGCAGGACCGCGACGGCACCATCATCCACCTCAAGTACCCGCTGAACTG

CTCCGATCCCACTAGTGAGAGGTGAGGGCTCCGCACCCCCGCCATTCCCA

AGCAGGGATGAGCCGGCTCCCACCCTGAACAGCCAGGGAGGCAGGGAGAC

TGGCAGCCGGCGCTGCCTACCCTCCATCCCCTCCCCTCCCTGCACCAGCT

GGGGCTCTCAATGTCCCTCCTCCCTGCTGTCCTGGGACCTGGTGTCTCAG

AGCCTAACCTACCACCCTTTCCACCTAACCCCGAGGAAGCCACAGAAAGC

TGCCTCGCCCTACTCCGGGAGCCCTGGCCGCTGCAACCCAGGTCCCACTG

GAGACAGGGAGGCCACTGCTGGTGGCCAGCATGTCGTGCAGGCCAGCTCT

GTTGTTAGAAAGCTCTTCTTCCTCTGGAATCGAGCCTGCCT

(SEQ ID NO: 265)

pARBI-661:
CTGGGTTCGAAGCCCGGTTAGAACTCTGGAGGCTAGGATGGCTTGAACCT
2541

PTPN6_2_
GGGAGGTCGAGGCTGCAGAGAGCTGTAACCGCGCCACTGCACTCCAGCCT

Exogenous_38
GGGCAACAGAGCTCTGGAAGCTTGCCCTAGAGTCAGTCAAGGGCCCTAGG

CCAGTGAGTAACAGCTCAGCGTCAGTTTCCTCATCTATAAAATGGGGGTA

ATATCATACCTAGCTCTCAGCATGTTTGTGAGAGACCTAAATGAGGTGGT

GGATTTGGAAGCATGTAGCGCAGTGCCTGGCACACAGTAGGTGCTTGATT

TCCGGCCCCTCTCTGTGAATGTCTCTGCTCAGCGCCTTCCCCTGTGGCCT

GGGTCTTACCTTCCCTGACGCTGCCTTCTCTAGGTGGTACCATGGCCACA

TGTCTGGCGGGCAGGCAGAGACGCTGCTGCAGGCCAAGGGCGAGCCCTGG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatACGTTTCTT

GTGCGTGAGAGCCTCAGCCAGCCTGGAGACTTCGTGCTTTCTGTGCTCAG

TGACCAGCCCAAGGCTGGCCCAGGCTCCCCGCTCAGGGTCACCCACATCA

AGGTCATGTGCGAGGTAAGGCAGCCAGGCGGCGGGGGAGCCTCTGCTGAG

GCTCCTGTCTGTGACCACAGTGTGGGTGGCAGGGAGGGTCTGCCTGGGCT

TGAATTCAAGGCTGGGGACCCAGGGAGGGAGACTCAAGTCCTGTGAATGG

CCTAATTTGGCTCCCCCCAGGGTGGACGCTACACAGTGGGTGGTTTGGAG

ACCTTCGACAGCCTCACGGACCTGGTGGAGCATTTCAAGAAGACGGGGAT

TGAGGAGGCCTCAGGCGCCTTTGTCTACCTGCGGCAGGTCAGGGGTGGGC

CCAGCTGCCTCCCCACTTCCCCTGAGCTGTCCCCCAGATGT

(SEQ ID NO: 266)

pARBI-662:
TGTCACATATGTGCAATGCCATGCTCCTGAGCCTTTGATTGCAGACGTGT
2541

PTPN6_3_
GGGAAGTGGGCCCCGTCCCCACCCCCAGTGCCACCCTGCTCTGCTTCTCT

Exogenous_39
TCCCTTGCTGTGCTCTAAAACGAGAAGTACAAGTGAGTTCCCCCAAGGGG

TCGGCCGCGCCTCTTCCTGTCCCCGCCCTGCCGGCTGCCCCAGGCCAGTG

GAGTGGCAGCCCCAGAACTGGGACCACCGGGGGTGGTGAGGCGGCCCGGC

ACTGGGAGCTGCATCTGAGGCTTAGTCCCTGAGCTCTCTGCCTGCCCAGA

CTAGCTGCACCTCCTCATTCCCTGCGCCCCCTTCCTCTCCGGAAGCCCCC

AGGATGGTGAGGTAAGGGCCTGCCACCCACGGTAGACAGGAGGCAAGGGT

GCCTGGTGCCCACGGGACCCCTCCTCACTGCCCTGCCTGGGCCGCCCAGG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatTGGTTTCAC

CGAGACCTCAGTGGGCTGGATGCAGAGACCCTGCTCAAGGGCCGAGGTGT

CCACGGTAGCTTCCTGGCTCGGCCCAGTCGCAAGAACCAGGGTGACTTCT

CGCTCTCCGTCAGGTAGGTGGGCCCCCCGCAACCCCGGGCATTTTGGCCA

CTCTCTTGTGCCATCCAGGCCCTGAACCACTCATTCCTGGTTCCCCGTGG

CAGTGCTGACTCCCCGTCTGTTCCCTTGCCCCCAACCCCCACACTCCCCA

TCCCTGTCTGTGCCCACCCATGCCCATGTGTGCCCCCACCCAGGACCTCA

GCCGATCCCTGCCCTCCTGCCTCTACTCCTGCACCGACTGGCCTCACCGC

CTGGTGCCCTGCAGGGTGGGGGATCAGGTGACCCATATTCGGATCCAGAA

CTCAGGGGATTTCTATGACCTGTATGGAGGGGAGAAGTTTG

(SEQ ID NO: 267)

pARBI-663:
TCTTTAGCTAATGTTCTGTAGCTTGTTTTAGATCTGTGTCTACATATTAT
2541

PTPRC_1_
ATGTATCTCTGTATGCATCAATATTTGTATATATGCATGCATATATGTGT

Exogenous_40
ATGTATATTTATGAATACATATACACACCATATACATACACTTATGTATG

GTGTGTGCATATGTATGTGTAGATATATGTACATACACACTATAGTGGAC

TGGGGAGTTAGTATACTGGGAGGAGCATACATTTAGGGTATGATTCACAT

ATTTATTTTGTCCTTCTCCCATTTTCCATTAATTAACAGGATTGACTACA

GCAAAGATGCCCAGTGTTCCACTTTCAAGTGACCCCTTACCTACTCACAC

CACTGCATTCTCACCCGCAAGCACCTTTGAAAGAGAAAATGACTTCTCAG

AGACCACAACTTCTCTTAGTCCAGACAATACTTCCACCCAAGTATCCCCG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatGACTCTTTG

GATAATGCTAGTGCTTTTAATACCACAGGTTGGCACACAAAAGTTGTTAA

CTTAAATATCAGGGAATGTCATTTAGAAAATTCTACAGTTATCAGTACAA

CTTGTCTTTAAATTATTTGCACAGTTTCTAAGTATGTGATTTTATTCAAG

TGCAGAAATTGCAGGAAATTAGTATCTGTGAAATATAGATCGACTGAAGT

AATTAATGCATGTTGTTAGGGAGTGGAGAGAGAAAAGAAGGGAAGCAAGA

TCTCCAAGGACAATCAGGAGGGGAAATTTGTTCTAGTATCCTCTGATCTA

TACACACTCGCCATGATTCTCCCGCTTGGCTTCCCGCCACCTGGACAGAT

GAGAATTTCCCTAGTTCAGAGATTATCAGTTCTACTCTCCTTGGAAGGTG

TCTTAAATGGGAGTCTTCCCATTTCTTTGTTTCACTCTAGA

(SEQ ID NO: 268)

pARBI-664:
AGGGAATTTTTATATGTTGGTCATATTATATCCCTAGCATGTGGCATAAT
2541

PTPRC_2_
GTCTAGCACAAAATAGGTGCTCAATTAATCATCATTATCTAAATAAATAA

Exogenous_41
TGCATTTGGGAAAAAAAAGTTTCAAAAGTTTTTCAAAAGTCTTTTGCAGG

CTTGAAATTAATCCCAATAGTGATCCTTTAGTCTGTTATGTTTCTGATTT

AGCCTGGGGATTCAAAAAATAAATAACATAATTTTGATATATTTGGGCTT

TGTAAACATGGTACTAAGAGAGGAAATATAGTTTCATTAGGGTAAAAGCT

ACTGAAAATTGCCACTTGGTGAATGTTCTATCATAGACTTGAGGTACATA

TAAAAATCTAATATATGTTTACATTAATATGAATGAAATTTGAAATTTTC

TAAGAGATTTTTGTTTCTTCTTTGCAGGGCAAAGCCCAACACCTTCCCCC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatACTGGTAAG

AATTAATATTTATATTTTTACTAATTTTATTTTCTTGTTGCAAAGTTTAT

ATATTTAACTACAATTTTCTATTATTAACACTGAAATTATTTTTAAGGAT

AAATTTTATAATCATGAGTGATTCTTGACATTCACTTGTTCTTAAACTTT

CTGCTTATACGTTATAGAGTTTAATAACTACCTAAACATGTTATTAAATT

TGTATATATATTTTGTGTATAAATAGTAACTTTTCCCAAACTTGACAGTA

AATCACACAACAGGTTTCTACTCTCTTTTAATATTTTAAGACTATAAAAA

AATGCATTTAAATTAGATAACAAAATTTTATAGTCTGAAAGCAGGTTAAC

AGCTGTCTATGTATGTTATAGATATGTAGATAACAGATTTGCATATGTCT

ATATTTCTTTAAGAGTATGTTGCTTTTTTCAATGGTATGCA

(SEQ ID NO: 269)

pARBI-665:
CCTTTAGCACCATAAAGAAACTAAATTATTTAGATGTTTTTATGAGAACA
2541

PTPRC_3_
TATCAAAAAGTACTTTTCTGTCATCCAATACTTCCACAAATAAATCATTA

Exogenous_42
GTTCTTGCTAATCTTCATCTGGCATAAAAATAATGACATCAACTTTCTTC

ATGTAATTTCCCACTTAATTCCTTTACTAGGAGCAATATCAATTCCTATA

TGACGTCATTGCCAGCACCTACCCTGCTCAGAATGGACAAGTAAAGAAAA

ACAACCATCAAGAAGATAAAATTGAATTTGATAATGAAGTGGACAAAGTA

AAGCAGGATGCTAATTGTGTTAATCCACTTGGTGCCCCAGAAAAGCTCCC

TGAAGCAAAGGAACAGGCTGAAGGTTCTGAACCCACGAGTGGCACTGAGG

GGCCAGAACATTCTGTCAATGGTCCTGCAAGTCCAGCTTTAAATCAAGGT

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatTCATAGGAA

AAGACATAAATGAGGAAACTCCAAACCTCCTGTTAGCTGTTATTTCTATT

TTTGTAGAAGTAGGAAGTGAAAATAGGTATACAGTGGATTAATTAAATGC

AGCGAACCAATATTTGTAGAAGGGTTATATTTTACTACTGTGGAAAAATA

TTTAAGATAGTTTTGCCAGAACAGTTTGTACAGACGTATGCTTATTTTAA

AATTTTATCTCTTATTCAGTAAAAAACAACTTCTTTGTAATCGTTATGTG

TGTATATGTATGTGTGTATGGGTGTGTGTTTGTGTGAGAGACAGAGAAAG

AGAGAGAATTCTTTCAAGTGAATCTAAAAGCTTTTGCTTTTCCTTTGTTT

TTATGAAGAAAAAATACATTTTATATTAGAAGTGTTAACTTAGCTTGAAG

GATCTGTTTTTAAAAATCATAAACTGTGTGCAGACTCAATA

(SEQ ID NO: 270)

pARBI-666:
aaggaaaaaggcactgagtgctggggggtgctggggtgggctgcagtgat

PTPRCAP_1_
agacatcagggtagaggttaaggtcaggttcagcctcactggggtgaagt

Exogenous_43
ttgagcacggtgagcaggccatgcagcccgggggaggggaggatgggagg

aggtggagctttccgggcagagggaacagccagtgcgaaggccccaggca

ggtggcttaatgcagctgttgggggaggtgagtggtagggaggaggctgg

agggatgggggctgatctcacagggccagagcctggttgaccaaataagg

ccttggccttttctGCTTGGCTGTCCCAAGAGGATCCCAAAGAGAAAAAA

ACGAAAGTGGTCTTGGTCACCCAGCCTGCCCCACACCAGGCCCCACCCCA

GGTGCTGAGCCCTCTGAGCCCCTGCCTGTCTCCCACAGGCTCTGCCCTGC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatACCTTAGGGC

TCGGGATGCTGCTGGCCCTGCCAGGGGCCTTGGGCTCGGGTGGCAGCGCG

GAGGACAGCGTGGGCTCCAGCTCTGTCACCGTTGTCctgctgctgctgct

gctcctactgctgGCCACTGGCCTAGCACTGGCCTGGCGCCGCCTCAGCC

GTGACTCAGGGGGCTACTACCACCCGGCCCGCCTAGGTGCCGCGCTGTGG

GGCCGCACGCGGCGCCTGCTCTGGGCCAGCCCCCCAGGTCGCTGGCTGCA

GGCCCGAGCTGAGCTGGGGTCCACAGACAATGACCTTGAGCGACAGGAGG

ATGAGCAGGACACAGACTATGACCACGTCGCGGATGGTGGCCTGCAGGCT

GACCCTGGGGAAGGCGAGCAGCAATGTGGAGAGGCGTCCAGCCCAGAGCA

GGTCCCCGTGCGGGCTGAGGAAGCCAGAGACAGTGACACG
2541

(SEQ ID NO: 271)

pARBI-667:
aaggtcaggttcagcctcactggggtgaagtttgagcacggtgagcaggc
2541

PTPRCAP_2_
catgcagcccgggggaggggaggatgggaggaggtggagctttccgggca

Exogenous_44
gagggaacagccagtgcgaaggccccaggcaggtggcttaatgcagctgt

tgggggaggtgagtggtagggaggaggctggagggatgggggctgatctc

acagggccagagcctggttgaccaaataaggccttggccttttctGCTTG

GCTGTCCCAAGAGGATCCCAAAGAGAAAAAAACGAAAGTGGTCTTGGTCA

CCCAGCCTGCCCCACACCAGGCCCCACCCCAGGTGCTGAGCCCTCTGAGC

CCCTGCCTGTCTCCCACAGGCTCTGCCCTGCACCTTAGGGCTCGGGATGC

TGCTGGCCCTGCCAGGGGCCTTGGGCTCGGGTGGCAGCGCGGAGGACAGC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatGTGGGCTCC

AGCTCTGTCACCGTTGTCctgctgctgctgctgctcctactgctgGCCAC

TGGCCTAGCACTGGCCTGGCGCCGCCTCAGCCGTGACTCAGGGGGCTACT

ACCACCCGGCCCGCCTAGGTGCCGCGCTGTGGGGCCGCACGCGGCGCCTG

CTCTGGGCCAGCCCCCCAGGTCGCTGGCTGCAGGCCCGAGCTGAGCTGGG

GTCCACAGACAATGACCTTGAGCGACAGGAGGATGAGCAGGACACAGACT

ATGACCACGTCGCGGATGGTGGCCTGCAGGCTGACCCTGGGGAAGGCGAG

CAGCAATGTGGAGAGGCGTCCAGCCCAGAGCAGGTCCCCGTGCGGGCTGA

GGAAGCCAGAGACAGTGACACGGAGGGCGACCTGGTCCTCGGCTCCCCAG

GACCAGCGAGCGCAGGGGGCAGTGCTGAGGCCCTGCTGAGT

(SEQ ID NO: 272)

pARBI-668:
cagtgcgaaggccccaggcaggtggcttaatgcagctgttgggggaggtg
2541

PTPRCAP_3_
agtggtagggaggaggctggagggatgggggctgatctcacagggccaga

Exogenous_45
gcctggttgaccaaataaggccttggccttttctGCTTGGCTGTCCCAAG

AGGATCCCAAAGAGAAAAAAACGAAAGTGGTCTTGGTCACCCAGCCTGCC

CCACACCAGGCCCCACCCCAGGTGCTGAGCCCTCTGAGCCCCTGCCTGTC

TCCCACAGGCTCTGCCCTGCACCTTAGGGCTCGGGATGCTGCTGGCCCTG

CCAGGGGCCTTGGGCTCGGGTGGCAGCGCGGAGGACAGCGTGGGCTCCAG

CTCTGTCACCGTTGTCctgctgctgctgctgctcctactgctgGCCACTG

GCCTAGCACTGGCCTGGCGCCGCCTCAGCCGTGACTCAGGGGGCTACTAC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatCACCCGGCC

CGCCTAGGTGCCGCGCTGTGGGGCCGCACGCGGCGCCTGCTCTGGGCCAG

CCCCCCAGGTCGCTGGCTGCAGGCCCGAGCTGAGCTGGGGTCCACAGACA

ATGACCTTGAGCGACAGGAGGATGAGCAGGACACAGACTATGACCACGTC

GCGGATGGTGGCCTGCAGGCTGACCCTGGGGAAGGCGAGCAGCAATGTGG

AGAGGCGTCCAGCCCAGAGCAGGTCCCCGTGCGGGCTGAGGAAGCCAGAG

ACAGTGACACGGAGGGCGACCTGGTCCTCGGCTCCCCAGGACCAGCGAGC

GCAGGGGGCAGTGCTGAGGCCCTGCTGAGTGACCTGCACGCCTTTGCTGG

CAGCGCAGCCTGGGATGACAGCGCCAGGGCAGCTGGGGGCCAGGGCCTCC

ATGTCACCGCACTGTAGAGGCCGGTCTTGGTGTCCCATCCC

(SEQ ID NO: 273)

pARBI-669:
ATAGAGTAGGGCGGGGGATGCCATGGAGAGGCTCCATGGGGGAGGGCCGG
2541

RPS23_1_
GGAAGCGCCGCTCCAGGAGGCACGTGGTCCGGCGCGGAAGGGGCCCATGA

Exogenous_46
GGCGTGGAGGCCGCCGAGGTCGGGGTACCGAGGGACGCAGGGAGGCCAGC

GCTTCCTCCCGGGCATTCGAGCGGGGCCTCGTCCTTCGGGAGAACACATT

CTCCGGAGCCCTCTTCGAACGTTTATTAGTCGGTTCAGGGCAACTTGAAG

GCCAAATGTTTGGCCCACAGGCCAATAAATAGTACGAGAGCCAATCGGCT

TAAGGGTTTATTCCAGGTGAGGCGAGTGTCTTAGAAGATGGGAAACACGT

AGATGGCGTGTTTTTACGGAAGAACTAAAATATTTAATTTTTAGGCAAGT

GTCGTGGACTTCGTACTGCTAGGAAGCTCCGTAGTCACCGACGAGACCAG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatAAGTGGCAT

GATAAACAGTATAAGAAAGCTCATTTGGGCACAGCCCTAAAGGCCAACCC

TTTTGGAGGTGCTTCTCATGCAAAAGGAATCGTGCTGGAAAAAGTGTAAG

TCCATTGCTCCCGTCAAGTTTTAGTTTATTATAGGAATTCGAGACATGAA

CTTACGAATTCTTGTTTTGAAAGTAATTGCAGGTTTTTGTGTAGTAGTAT

TCATTTGGGCATTGTGGGGTAAAATTGCAAAGCGTTTGTTCTATTTAAAA

GTTGGTAAAATTAGTTTTTGGGAATTAGGTAGTTAAGGTTTTAATTTAAC

GTTGGCCTGGAAGGAATTGGAGAAGATACTAGCAATGATGAAGTAAAGGA

CACAAACACCTTTACTGTGGGAGTTGTTATAAGTAAATGGCACGTGTCAG

CTATTGAACTTTATCGACTTGATAAAACTAAGGTGAAGAGA

(SEQ ID NO: 274)

pARBI-670:
CAAGCGGGACTTGGGGTCTTGGGGACGGGCGGGCGGATGCGAATAGAGTA
2541

RPS23_2_
GGGCGGGGGATGCCATGGAGAGGCTCCATGGGGGAGGGCCGGGGAAGCGC

Exogenous_
CGCTCCAGGAGGCACGTGGTCCGGCGCGGAAGGGGCCCATGAGGCGTGGA

47_48
GGCCGCCGAGGTCGGGGTACCGAGGGACGCAGGGAGGCCAGCGCTTCCTC

CCGGGCATTCGAGCGGGGCCTCGTCCTTCGGGAGAACACATTCTCCGGAG

CCCTCTTCGAACGTTTATTAGTCGGTTCAGGGCAACTTGAAGGCCAAATG

TTTGGCCCACAGGCCAATAAATAGTACGAGAGCCAATCGGCTTAAGGGTT

TATTCCAGGTGAGGCGAGTGTCTTAGAAGATGGGAAACACGTAGATGGCG

TGTTTTTACGGAAGAACTAAAATATTTAATTTTTAGGCAAGTGCCGCGGA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatCTTCGTACT

GCTAGGAAGCTCCGTAGTCACCGACGAGACCAGAAGTGGCATGATAAACA

GTATAAGAAAGCTCATTTGGGCACAGCCCTAAAGGCCAACCCTTTTGGAG

GTGCTTCTCATGCAAAAGGAATCGTGCTGGAAAAAGTGTAAGTCCATTGC

TCCCGTCAAGTTTTAGTTTATTATAGGAATTCGAGACATGAACTTACGAA

TTCTTGTTTTGAAAGTAATTGCAGGTTTTTGTGTAGTAGTATTCATTTGG

GCATTGTGGGGTAAAATTGCAAAGCGTTTGTTCTATTTAAAAGTTGGTAA

AATTAGTTTTTGGGAATTAGGTAGTTAAGGTTTTAATTTAACGTTGGCCT

GGAAGGAATTGGAGAAGATACTAGCAATGATGAAGTAAAGGACACAAACA

CCTTTACTGTGGGAGTTGTTATAAGTAAATGGCACGTGTCA

(SEQ ID NO: 275)

pARBI-671:
TTGTATATCCTTTTTAAAGTTATTCTTTTTAGTTAATTGCTCTATGTGTA
2541

RTRAF_1_
TTGAGACTAGGAATCAGAAAGCTTAGATTCTAGTCCCAGGTGTAAGTTGT

Exogenous_49
GTAACCCTTGGCAAGTGTCAATCTCTAGGCCTCAGCTTTCTCATCTATAA

AATGAGGAAGTTGTCGTATTCTATTTTTTTTCTTAAGATGATACACTTAA

ATGTTCCCTTCTGTTGGGTTATATAATTGCATCAAAAGTGTAGTAATGTT

ATTAAAAAATTGTTAGAGATCCAAACTAAGGTCTCTTTCAACTCTCCCAT

TCTTTTTTCTGTGACTTTATGGTAATAATGAAACTGGTGGTTTTCTTTTC

TTCCCCCTCACAGTATCTCAGAGATGTTAACTGTCCTTTCAAGATTCAAG

ATCGACAAGAAGCTATTGACTGGCTTCTTGGTTTAGCTGTTAGACTTGAA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatTATGGAGATA

ATGGTACGTTTTGTGGGGAATGTGTATTTTAAAGAGAGAGGAAAGATGGG

AAAGGGAGTGTGAAAATGTAGGGAACTTTGCAGTTTGTTTTGTCTAGTAC

TATTTTACCTTTGGTTTATTCTTATCACAAGTTAAAAGCACTTTTATTGT

CTTTCATTGGTGTTTATATATTTCTGTTAGAATTTGGAAATGGTGCCCTC

TGGAGAAGGCTAATTGACTGTCTTCTCACAGAGTAACACTACTTTGATAA

TATGGTCTGCACCTTAGCCTTTCAAATTAAATTGTTTTTAGTGTCCCAGA

ATTGATGGGACTTTGAAGTGTTGTTGCAGTAGGTAATTTCTCAAAAGACT

GAAACATGTCTAATGCCAATATACATTAATACTCTATAGGCCAGAATATA

TTACTTATGTTTACTGTCTTAGCACAGATACTTCTATGGT

(SEQ ID NO: 276)

pARBI-672:
GCACCTGTTATGTAGGAGGAGTAATAAAATGAATGAATGCACTCAAAACA
2541

RTRAF_2_
CTAAACAGTAATTCTGTAATCCAACGGGAGGTACAGCGAATACCAAAAGC

Exogenous_50
CTACATATACTATTCTCTGCATGCTATAGCAAGAAAGAAAGGAAAGTGGC

TTCCCGGTGGTTTTCTGCCTATTGTACAACCAGGAAGCTGACAATAAAGT

TTATTTGAGCGTCGACGTGCGCCGACGTGGCCCCGCCTCCCCAGCCGGAG

CCGCGATTGGTGGGCATTTGCCGGCGGCCACCGCTTTTAAGCCACGATTG

GCGAAGGCCGCCGTCATTTCGGAGCGACTCAGCGCCTGCCCGCCCTCTCG

CCGCGTCGCCGGTGCCTGCGCCTCCCGCTCCACCTCGCTTCTTCTCTCCC

GGCCGAGGCCCGGGGGACCAGAGCGAGAAGCGGGGACCATGTTCCGACGC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatAAGTTGACG

GCTCTCGACTACCACAACCCCGCCGGCTTCAACTGCAAAGGTGAGGCGGC

GGCCTCAGCCCGGCCGCGTGTCCCTGACCTGGGCGGAGGTCCCAGCCTCA

GTGCCCGCACCCCACCTCCCCGTCGGGACCCTCGGCGGCCTGGTTTCCGC

CGGCAGCCTCCGGGCCCCTCTCCTCTGGGTCGCCACGTACCTCGGCTCTT

CGCCGCCCCTTCCCGCCTTTAAAGCCCTCTCACCTACTCCTGTCTCGGCA

TGTTACTTTCTGCACTTGCTTAACTCCAAGCATCACGTAACTACCTTCTC

TGTACATAAAAGGGAGAGCATTCGTCTTTCTCACTCACTATTCAACTCCA

TGGTTCCCTGGGTAATTAGGCGATACCTTGAGCACCTGCTAATTATGGGC

CAGCGCGGTGCTGGATTCTGAGGAAGGTGCTGAGTAACTTG

(SEQ ID NO: 277)

pARBI-673:
CACTAAACAGTAATTCTGTAATCCAACGGGAGGTACAGCGAATACCAAAA
2541

RTRAF_3_
GCCTACATATACTATTCTCTGCATGCTATAGCAAGAAAGAAAGGAAAGTG

Exogenous_51
GCTTCCCGGTGGTTTTCTGCCTATTGTACAACCAGGAAGCTGACAATAAA

GTTTATTTGAGCGTCGACGTGCGCCGACGTGGCCCCGCCTCCCCAGCCGG

AGCCGCGATTGGTGGGCATTTGCCGGCGGCCACCGCTTTTAAGCCACGAT

TGGCGAAGGCCGCCGTCATTTCGGAGCGACTCAGCGCCTGCCCGCCCTCT

CGCCGCGTCGCCGGTGCCTGCGCCTCCCGCTCCACCTCGCTTCTTCTCTC

CCGGCCGAGGCCCGGGGGACCAGAGCGAGAAGCGGGGACCATGTTCCGAC

GCAAGTTGACGGCTCTCGACTACCACAACCCCGCCGGCTTCAACTGCAAA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatGGTGAGGCG

GCGGCCTCAGCCCGGCCGCGTGTCCCTGACCTGGGCGGAGGTCCCAGCCT

CAGTGCCCGCACCCCACCTCCCCGTCGGGACCCTCGGCGGCCTGGTTTCC

GCCGGCAGCCTCCGGGCCCCTCTCCTCTGGGTCGCCACGTACCTCGGCTC

TTCGCCGCCCCTTCCCGCCTTTAAAGCCCTCTCACCTACTCCTGTCTCGG

CATGTTACTTTCTGCACTTGCTTAACTCCAAGCATCACGTAACTACCTTC

TCTGTACATAAAAGGGAGAGCATTCGTCTTTCTCACTCACTATTCAACTC

CATGGTTCCCTGGGTAATTAGGCGATACCTTGAGCACCTGCTAATTATGG

GCCAGCGCGGTGCTGGATTCTGAGGAAGGTGCTGAGTAACTTGAAGACTA

GTTCACTGCCTGCCAGGAGCTAAAGGGACGAGGGGTGGAAG

(SEQ ID NO: 278)

pARBI-674:
CCGGGTTAGGCATAGGCCCTCCCGGATCTTCCGCGGTGTAAGGAGAAGGC
2541

SERF2_1_
CAGCGCCCCTGTGATAGGCCCAGAGCCCCCACTCCACAAGCCAGCCCATC

Exogenous_52
CCCCACGGAGACCCAAACCGTCCACACACACCTTGCCAGCTGTTTGGGCC

CCACGCCGCCCCAAAACACGCCTCCAGCTGGCCCCTTGGGACCTCCCTTC

TCTAGTCCGTATTTTGACCTGGCCCGTGGCAGATTCGCCACTCCCCCCTA

CCCCAAGCAGCCTGGGCCTCGATGGGCCGTTGTCGGGGCCCGGAGATTGA

AGTGGTGTTGGATCCTGCTGCTGGCCGCGCTGGGGTAGAAGGGTCGCCGG

TGTGTGGGCAGAGCGGCCCCCGCGTCTCACCTTTAATTTTCTTTCCTTAG

GCGGTAACCAGCGTGAGCTCGCCCGCCAGAAGAATATGAAAAAGCAGAGC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatGACTCGGTT

AAGGGAAAGCGCCGAGATGACGGGCTTTCTGCTGCCGCCCGCAAGCAGAG

GTAGCCCCAGGGAGGGGAGGGAAAGGGACGGTGGAGACCTGGGTTAGACC

AAGGGTTATAGAAGGAAAGAGAGCTACCTCAGGGCTTGAATGTGGACTAG

TCGTGAGGAGCAGAGTGCATTGCTTCCTCTAGGGTTTTATTTCCTCCCCA

CCCTCCAAATTGTTAGCTCACAGCCTTACAGGAAAGGACGGGGGCGGGCG

CCTGCCCTCAGTCTGATTTCTGAGCGTCCCTGGGTCTGACCTTAAGGGCA

AGGGCAGGGAGCTTCACATTTCAAATACAGTTGTGGTTACGGCAGCCCAG

TACTTTTGGCCCTCCTTGCTGTTCGGTTCTCCTCCCTTCTCCCAACCTCC

TCACTGGTGTTGCTGGGTGTGGTCCTCAATACAGAATAGAG

(SEQ ID NO: 279)

DARBI-675:
AATCGAGCCCTTTGCCCACGGCTACTTCACGGGACCACCCTCCCGGGTTA
2541

SERF2_2_
GGCATAGGCCCTCCCGGATCTTCCGCGGTGTAAGGAGAAGGCCAGCGCCC

Exogenous_
CTGTGATAGGCCCAGAGCCCCCACTCCACAAGCCAGCCCATCCCCCACGG

53_54
AGACCCAAACCGTCCACACACACCTTGCCAGCTGTTTGGGCCCCACGCCG

CCCCAAAACACGCCTCCAGCTGGCCCCTTGGGACCTCCCTTCTCTAGTCC

GTATTTTGACCTGGCCCGTGGCAGATTCGCCACTCCCCCCTACCCCAAGC

AGCCTGGGCCTCGATGGGCCGTTGTCGGGGCCCGGAGATTGAAGTGGTGT

TGGATCCTGCTGCTGGCCGCGCTGGGGTAGAAGGGTCGCCGGTGTGTGGG

CAGAGCGGCCCCCGCGTCTCACCTTTAATTTTCTTTCCTTAGGCGGTAAC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatCAGCGCGAG

CTTGCCCGCCAGAAGAATATGAAAAAGCAGAGCGACTCGGTTAAGGGAAA

GCGCCGAGATGACGGGCTTTCTGCTGCCGCCCGCAAGCAGAGGTAGCCCC

AGGGAGGGGAGGGAAAGGGACGGTGGAGACCTGGGTTAGACCAAGGGTTA

TAGAAGGAAAGAGAGCTACCTCAGGGCTTGAATGTGGACTAGTCGTGAGG

AGCAGAGTGCATTGCTTCCTCTAGGGTTTTATTTCCTCCCCACCCTCCAA

ATTGTTAGCTCACAGCCTTACAGGAAAGGACGGGGGCGGGCGCCTGCCCT

CAGTCTGATTTCTGAGCGTCCCTGGGTCTGACCTTAAGGGCAAGGGCAGG

GAGCTTCACATTTCAAATACAGTTGTGGTTACGGCAGCCCAGTACTTTTG

GCCCTCCTTGCTGTTCGGTTCTCCTCCCTTCTCCCAACCTC

(SEQ ID NO: 280)

pARBI-676:
TTCAAAAGGAATCTTTTTGTTTCAACTATTAGGATCTTTTTAAATCAAAT
2541

SLC38A1_1_
ATGTATTTTAATGGTGTACACCAGACCTGAAGAAAAAGATCACAGAAGGA

Exogenous_55
ATTTCCCCTTTGTAAGATAGAGGTAGTTAAAAATAAGCCTTATGACCTAA

TAGGTTAATTGTAATGCTCTGGTAGCCAACTTGAAAAAGGAGAAATGATG

GTTGCATCTCACATTTTAAAATGTTAAGAATTTGTTTTGTAATGAGGATA

CCTTAACCCCTGAAGGCCAAAATGACTATTTGTGTGAGTTTGAGAAAGGC

ACATAGTAACTTGGGGAACAGTCAATAGAATGACAAAATCTTGACTATTT

TAACTTTCTGAACCCTGTCATTTCTTGTGTTCTCAAATTTGATTTTTAAA

TAGGCTGCATGGTGTATGAAAAGCTGGGGGAACAAGTCTTTGGCACCACA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatGGGAAGTTCG

TAATCTTTGGAGCCACCTCTCTACAGAACACTGGAGGTAAAAAGAACATG

CTTTTCTTTACATAACTTGAAACTAATTCTGGTGGATGAGCGGCCACATG

AATTTTAACATAATTCAAGCAGTTATCATCCTCATTGCTAAAATGGCACA

GGGAAAGTAAAGCAGAGACAGCAGTCACTTATTTAAAGCCACAAATCCTG

CTAGAGTAGCTGAAGTTGCCTTTGTGTCTTACTGACAGTTGGTCTAAGAA

CGGGCTGATAACTTTTTATGTAGCTTGCAACATAAGCCTTCGTATCTTCT

TTCTAAAAATGTTCTCATTTTCCTTCAGCAATGCTGAGCTACCTCTTCAT

CGTAAAAAATGAACTACCCTCTGCCATAAAGTTTCTAATGGGAAAGGAAG

AGACATTTTCGTAAGTTATAGACCATTITTTTATGATATA

(SEQ ID NO: 281)

pARBI-677:
TAAAGATGTCAAGCTTCAAATCATTATCATAAGGTTAAATATATTACGCA
2541

SLC38A1_2_
TGTCTTTACAGCAAGTTTATTTCTGATCGTGAAAGTAGAAGAAGTCTCAC

Exogenous_
AAACAGCCATTTGGAAAAAAAGAAGTGTGATGAGTATGTAAGTATCATTA

56_57
TAATGAAGTATGCTTATTTTTTTAATCATATAAATTGGGACAAATCTTTT

TAATTCAAGTAGCATAGTACCAAAAGCATAACTACCTGTATTCACCAGGA

TATTCCTCATACCTTATGTATTTTCTCTTGAAATCCATTCAAGGAAATAA

CTAGATAACTAAGAATGGATTTTCTTGAATTTTACTTCCATATTGGTTCC

TGAGAGTGCATTAAAGGCTTTGGCTTGATGAACTTTCTTGGGGATTATTT

TGCTTAGTGTCAATGTTTGTTTCTTTGTTCAGATTCCAGGTACAACCTCC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatTTAGGCATG

TCAGTTTTTAACCTAAGCAACGCCATTATGGGCAGTGGGATTTTGGGACT

CGCCTTTGCCCTGGCAAACACTGGAATCCTACTTTTTCTGTGAGTATTGA

CGTGCCGGTACTTTCCATTTTAAAACTGAACTTTTTGTATGTTTCTGTTA

TTACATAGAAGAAATGTGAAATATTTATAAATAGTTTTTTTATTAACTTG

GCTAAGTTACAAGTACATACTTTGATATTTATTGCTTGAGTGATTTTCCA

AACTGTACCTAATGCTTACAACAAAGAGGAAGGAGAAAATCTTTTTATTA

ATCAAAAATACTGAAATAAGCATTTGTGAAAAGGATTAAAACATTTGAAA

ATAACTTTTTTTGGTATTTTTGGAGTCTACCTGTGACTTTAAATCTCAGT

TAAAATATTAAGAGGTGTTTAACCCCAGCCAGTCACCACTT

(SEQ ID NO: 282)

pARBI-678:
ATCATTCTTCACACTAGTTCCTTTTCTGACTCTTCAGTCACCTCCAGAAT
2541

SMAD2_1_
TAATATCCTTAGAAGCATCTCTAAAATGAGTTTGATTTACTAAACATAGA

Exogenous_58
AGTTGACAAAGTTTTTCAAGTATAACTGCATAAACTCTCTTTTTTAAAAA

ATCAGTTTTTCCCAAGTTGTTAGCCTTTCATTGGCATTTGAGTCATTTAT

GTGACATATTTATAAGAAACATCTGCTAGTGCTGCTGCATACTTTTATCA

GATCCATTAAATAGTACATTTTTGTTCTTGATTCTCACTAAAACTAACTA

AATGGCTGTCATTCTTTTCTTTATGCTTTTATTGTACTAATTTAGCCCAT

TTGACTGCACttttttttttttttttttAAAGTTCCCTCCTTTCTTTTCC

CCTTGCTTCCCAACAGGTCTCTTGATGGTCGTCTCCAGGTATCCCATCGA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatAAAGGATTGC

CACATGTTATATATTGCCGATTATGGCGCTGGCCTGATCTTCACAGTCAT

CATGAACTCAAGGCAATTGAAAACTGCGAATATGCTTTTAATCTTAAAAA

GGATGAAGTATGTGTAAACCCTTACCACTATCAGAGAGTTGAGACACCAG

GTAGGAATATTGCAAGTTTTTTTCTTGGTTTTGAATTAAATGCCTGAACT

TCAGTATATTTAAGTACTCTTGTGACCCAGGAAAATTTTAGTGTAAATTC

TAATAAATTACCTTAAATTGTGCATATTATTTGGTGGTAATTAAAAtttt

tttatttttaaaaatttttAATGAGAAAACATATCTGTTTCTTGGAATAG

CATATGATTTGGCATGAAAGTGCATATCCAGGAAATCCTGTAGATTGGCA

GTCTGCTCAGCGCTATGCTGATGTGCTTCTACATGTCCCT

(SEQ ID NO: 283)

pARBI-679:
TTCTATATTAAAAATCAGTTGACATCTGTTTTTAGATAATTTTTTAAAAA
2541

SMAD2_2_
ACTGGATTATAAAATGAAGCACTTAGTAAAGCTGATGGCAGAGGTTTTAG

Exogenous_59
ATCTTTTGAATACAGGAAAGTGGTAAGGGCATTATAGGTATGATTCATTG

AGCTAGAGGGCGTTGGTGTTCACATTTTAAAAACATAATCATGACTTATC

TGGAGTCACATGTTCCATTTTATTGGCTTCCTTCATATAGAAAATATAGT

AACCAGCACTACATGCCTGTGAAAAAGTGAAGCAATTGTATATTTTCTGG

GTGAAGGAAGTATTCTGTACATTCTCCATGTTTTACATCATGGTATTTTG

AATAACCATGCTTCCATGTTCACATCAATTTTTTGTTTTTCAATTTATGC

ACAGCACTTGCTCTGAAATTTGGGGACTGAGTACACCAAATACGATAGAT

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatCAGTGGGAT

ACAACAGGCCTTTACAGCTTCTCTGAACAAACCAGGTGAATATTCTGCCC

TCTGTCGAATCTTAGAGATCTTGTGGGAGGGGGGTATATTTTGAAAGACC

TATATGGGGTTGCTTAGTATAATTTTGCCTAGGATGTTTCCTTAATGTAA

AATAAGGCATAGCATTTAAAATATCTGCTTGCCAGTATAAAAAATATATT

AAATGTTTCAGCTGATGTTTTAATCAATGCAATTCTAGTTTGAATCTTCT

TTAAATTACTGTATCCCCTAAAGAATAATAATTTTGATAACTATATATTT

ATTTTAGCTTGAGATCAGATTATAATCTGTTGTTGGCCTAATTTTTAAGT

AGATACATGATGAGTTTTGCTAAATTTCTTGTTATCAGAATCTCATCTTT

ATACTAATAAATACATACTTAATGAACCCCTTATATCACAA

(SEQ ID NO: 284)

pARBI-680:
TCAATGTATTTTTGTATAGTCTTTTGAGATTAGAGTGAAGTTCTAAAAAG
2541

SMAD2_3_
TAAGAGAACCTTTTGTGAAAATATTTTAATTGACACTACTAAGAGTTTAA

Exogenous_60
AATAGTATTGGTGGTGAAAAATCGTTAAAAGTATCTGATTTTACTTGCAA

AATTACTGTATTTTCCCACAAGAGGAGTCCTTACAACATTCTTGTTTTTA

GAAGGGTTTGTTTCCATCATTCATTTAAATTCATAAAGATAACGTTTTCA

TGGGTGGAGAAGTCTATTGGGAAAGTCATAATTCGAATTTCTATCTTGCT

TTGCAGTTTGCTTTCTATGATAAGTTGAAATTATTACTTGATGTTCAAGG

TAGTCTCTACATCATCCTTTCAATATTTCTGCTAGGTTCGATACAAGAGG

CTGTTTTCCTAGCGTGGCTTGCTGCCTTTGGTAAGAACATGTCGTCCATC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatTTGCCATTCA

CGCCGCCAGTIGTGAAGAGACTGCTGGGATGGAAGAAGTCAGCTGGTGGG

TCTGGAGGAGCAGGCGGAGGAGAGCAGAATGGGCAGGAAGAAAAGTGGTG

TGAGAAAGCAGTGAAAAGTCTGGTGAAGAAGCTAAAGAAAACAGGACGAT

TAGATGAGCTTGAGAAAGCCATCACCACTCAAAACTGTAATACTAAATGT

GTTACCATACCAAGGTAAGTTTTGTTAGATCCCAGGTTTGATCAAATTAT

GTCAAGGAATCTGAAGGAAAGTTACTGAATTTGTGTTCCTTTCAAGTTGC

CTGTAAAAAGTGATGATTGAAATATGACTGTTTTTAACCTTGTATAAATT

GTTTTTGCTAGCTGACTTGTTTTATAAATTATTTTCTTGAATAGTGAGGT

TTAATCAAGCTAAATAAGATACTTAGATTTATTATCTTCA

(SEQ ID NO: 285)

pARBI-681:
GGGCTCCCGCAGCACAGCCTTTCTCCGGCCCTAGCCCAAATCGCCCAGAC
2541

SOCS1_1_
CAGGCGCGGATCCCAGCCTGGCCAGCAGGCGGCGGGCGCGGGGCGGCGAG

Exogenous_61
CCGGGGCCGGACGGCTGGAGCCAGAACCGGCTGCTCTCCACGCCCCCCTC

TCGGTGCTGCCCGGAGGCCGGACTCCGCCTCCACCGAGCCCCCACCCGCC

GGGAAGAGCTCCGCGGAGTACAGAGCCCATTTTCTAGCTGTGTCCACTGA

GGCTGAACGGATCCGCGCGGACTTGGTGCTCCGTGCTCGCCCCCTAGGGC

CGGGTCCGCCGGGAGCGCCGCCCTCCGGAGTTGTCCGGCCGGCGCACACC

TGCCCGGCCCCGCAGCGCCCCAGCTCACCTCTTTGTCTCTCCCGCAGCGC

ACCCCCGGACGCTATGGCCCACCCCTCCGGCTGGCCCCTTCTGTAGGATG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatGTAGCACAC

AACCAGGTGGCAGCCGACAATGCAGTCTCCACAGCAGCAGAGCCCCGACG

GCGGCCAGAACCTTCCTCCTCTTCCTCCTCCTcgcccgcggcccccgcgc

gcccgcggccgtgccccgcggtcccggccccggCCCCCGGCGACACGCAC

TTCCGCACATTCCGTTCGCACGCCGATTACCGGCGCATCACGCGCGCCAG

CGCGCTCCTGGACGCCTGCGGATTCTACTGGGGGCCCCTGAGCGTGCACG

GGGCGCACGAGCGGCTGCGCGCCGAGCCCGTGGGCACCTTCCTGGTGCGC

GACAGCCGCCAGCGGAACTGCTTTTTCGCCCTTAGCGTGAAGATGGCCTC

GGGACCCACGAGCATCCGCGTGCACTTTCAGGCCGGCCGCTTTCACCTGG

ATGGCAGCCGCGAGAGCTTCGACTGCCTCTTCGAGCTGCTG

(SEQ ID NO: 286)

pARBI-682:
GGATCCCAGCCTGGCCAGCAGGCGGCGGGCGCGGGGCGGCGAGCCGGGGC
2541

SOCS1_2_
CGGACGGCTGGAGCCAGAACCGGCTGCTCTCCACGCCCCCCTCTCGGTGC

Exogenous_62
TGCCCGGAGGCCGGACTCCGCCTCCACCGAGCCCCCACCCGCCGGGAAGA

GCTCCGCGGAGTACAGAGCCCATTTTCTAGCTGTGTCCACTGAGGCTGAA

CGGATCCGCGCGGACTTGGTGCTCCGTGCTCGCCCCCTAGGGCCGGGTCC

GCCGGGAGCGCCGCCCTCCGGAGTTGTCCGGCCGGCGCACACCTGCCCGG

CCCCGCAGCGCCCCAGCTCACCTCTTTGTCTCTCCCGCAGCGCACCCCCG

GACGCTATGGCCCACCCCTCCGGCTGGCCCCTTCTGTAGGATGGTAGCAC

ACAACCAGGTGGCAGCCGACAATGCAGTCTCCACAGCAGCAGAGCCCCGA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatCGGCGGCCA

GAACCTTCCTCCTCTTCCTCCTCCTcgcccgcggcccccgcgcgcccgcg

gccgtgccccgcggtcccggccccggCCCCCGGCGACACGCACTTCCGCA

CATTCCGTTCGCACGCCGATTACCGGCGCATCACGCGCGCCAGCGCGCTC

CTGGACGCCTGCGGATTCTACTGGGGGCCCCTGAGCGTGCACGGGGCGCA

CGAGCGGCTGCGCGCCGAGCCCGTGGGCACCTTCCTGGTGCGCGACAGCC

GCCAGCGGAACTGCTTTTTCGCCCTTAGCGTGAAGATGGCCTCGGGACCC

ACGAGCATCCGCGTGCACTTTCAGGCCGGCCGCTTTCACCTGGATGGCAG

CCGCGAGAGCTTCGACTGCCTCTTCGAGCTGCTGGAGCACTACGTGGCGG

CGCCGCGCCGCATGCTGGGGGCCCCGCTGCGCCAGCGCCGC

(SEQ ID NO: 287)

pARBI-683:
CGGACTCCGCCTCCACCGAGCCCCCACCCGCCGGGAAGAGCTCCGCGGAG
2541

SOCS1_3_
TACAGAGCCCATTTTCTAGCTGTGTCCACTGAGGCTGAACGGATCCGCGC

Exogenous_63
GGACTTGGTGCTCCGTGCTCGCCCCCTAGGGCCGGGTCCGCCGGGAGCGC

CGCCCTCCGGAGTTGTCCGGCCGGCGCACACCTGCCCGGCCCCGCAGCGC

CCCAGCTCACCTCTTTGTCTCTCCCGCAGCGCACCCCCGGACGCTATGGC

CCACCCCTCCGGCTGGCCCCTTCTGTAGGATGGTAGCACACAACCAGGTG

GCAGCCGACAATGCAGTCTCCACAGCAGCAGAGCCCCGACGGCGGCCAGA

ACCTTCCTCCTCTTCCTCCTCCTcgcccgcggcccccgcgcgcccgcggc

cgtgccccgcggtcccggccccggCCCCCGGCGACACGCACTTCCGCACA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatTTCCGTTCG

CACGCCGATTACCGGCGCATCACGCGCGCCAGCGCGCTCCTGGACGCCTG

CGGATTCTACTGGGGGCCCCTGAGCGTGCACGGGGCGCACGAGCGGCTGC

GCGCCGAGCCCGTGGGCACCTTCCTGGTGCGCGACAGCCGCCAGCGGAAC

TGCTTTTTCGCCCTTAGCGTGAAGATGGCCTCGGGACCCACGAGCATCCG

CGTGCACTTTCAGGCCGGCCGCTTTCACCTGGATGGCAGCCGCGAGAGCT

TCGACTGCCTCTTCGAGCTGCTGGAGCACTACGTGGCGGCGCCGCGCCGC

ATGCTGGGGGCCCCGCTGCGCCAGCGCCGCGTGCGGCCGCTGCAGGAGCT

GTGCCGCCAGCGCATCGTGGCCACCGTGGGCCGCGAGAACCTGGCTCGCA

TCCCCCTCAACCCCGTCCTCCGCGACTACCTGAGCTCCTTC

(SEQ ID NO: 288)

pARBI-684:
GGCAGACAAACAGTTAAAACAGAGGAGTGGGGTAAGTGATGACCTAACCC
2541

SRP14_1_
AGCCCCGCTGCTCTAGTTTTGTTAAACACCTCATCTGCTATCACGGTCTG

Exogenous_64
GCGAAACCCTGGAGAAACTATTATTTCCACGACGGAAACATGTAATATCG

AAGCACGTTAAATTCCACTCAAAGTGGCGGCGTCTGGGATCCCTGACAAA

GAGCCCTGGGCTGCTTGGGGCCCATTGTTACCAGAAGCAACCTAGGCGGC

TCAGTGCTGGGGACTGAGCCAGCTACAATCCCTACTATTTTCCGGGCCCG

AAGCCCCGAATGTGCTCAGTACAGGGTGGGGAAAGGTAGAGGAAGGCGGC

GGTCCGCGGCAGACAGACTCCGGTGGCTCCCAGACACCGGGAACCCAGGG

AGCATCGCCCGGCTCCCCTCCCGCTGCTTACACTTCTTCAAGGTGATATA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatGACGCTGCC

CGACGTCCGGCACTTCTGGAAAAGTCTGGTCAGCTCCGTCAGGAACTGGA

AAACAACAGGCCCAGCCCCGTTAGCCAGCCCCAAATCCTCGTCCTGCCGC

GTCAAGGCCCTGGTCCTCCTGCAGGAGGCACAGGTCTCGAGTAACGCCTG

AGCCGCCCCCTTCCCTCGGCCGGCCAGGCCTAGCCATACCTGCTCGCTCT

CCAACAACACCATCGCGGCGACGCTGGCTCGACTCCCTCCGCTTAAGCCC

CTAGCAGTGAGAGCCGGAAGTTCGGCCTAGGCTGGGCGGGACTTCCGCTA

CTAGACTTCCATTGTCTTCCACCAATCTCTTCTCTTCCACCAATCCCGGC

CTGCGCCCTCCCCCCTCCCCGCCCGCCTAGCGCCCGCGCCCTGGGACGTC

CGGGGGCCTGTGACCCGGAGGCGCTGGGGCTGTCCTGGGTC

(SEQ ID NO: 289)

pARBI-685:
GTCTGTCTGCCGCGGACCGCCGCCTTCCTCTACCTTTCCCCACCCTGTAC
2541

SRP14_2_
TGAGCACATTCGGGGCTTCGGGCCCGGAAAATAGTAGGGATTGTAGCTGG

Exogenous_
CTCAGTCCCCAGCACTGAGCCGCCTAGGTTGCTTCTGGTAACAATGGGCC

65_66
CCAAGCAGCCCAGGGCTCTTTGTCAGGGATCCCAGACGCCGCCACTTTGA

GTGGAATTTAACGTGCTTCGATATTACATGTTTCCGTCGTGGAAATAATA

GTTTCTCCAGGGTTTCGCCAGACCGTGATAGCAGATGAGGTGTTTAACAA

AACTAGAGCAGCGGGGCTGGGTTAGGTCATCACTTACCCCACTCCTCTGT

TTTAACTGTTTGTCTGCCGCTCAGCCACGTACGCGGCCGTGTTCACCAGG

ATGCATTTTTTCCTTCAGATGACGGTCGAACCAAACCCATTCCAAAGAAG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatGGTACTGTG

GAGGGCTTTGAGCCCGCAGACAACAAGTGTCTGTTAAGAGCTACCGATGG

GAAGAAGAAGATCAGCACTGTGGTGAGCTTAATTTCTAAGGCTGTCTTTT

GAAATGTAAAGACTTGAACTTAACAGAGGATGGGGCGTTTCTGAACCAGG

CTTTTATTTGTTTTTCCCTTTTGCCCTGTGTGGCTATTTTTGAGACCAGG

ACCTTCCTATACTTTAGTAGTGGAAACCTCAAGAATAAAATAAGAAGGTA

GAGGTCAGACAGTCGTTAGTTCTGCTAAAGCTCTTGTGGAAATGAAAGTA

GCATATTGGTCCTTATTCGTAGTACTGTAAGGAGCAGCTGGCATAAATAT

TTGATTCCTTAGCCCCTTACTGTGCTGGGCCTTCAATAAGCAGTTTCTTG

GTACCAGGTGATGCTATTATTTCCTTATCTTTGTGGTTCAC

(SEQ ID NO: 290)

pARBI-686:
CCCACGTCAGTGAGTGCTCACAAGTCTGTGAGGTAGGCGGCGCCACAGAG
2541

SRSF9_1_
AGAAACTGAGGCGCGGGAGCCCAAGCCACTTGTCCAGCGCCTCAGCCGAG

Exogenous_67
CGCGAACCGCGCTCGGGGATGGCATCCACACGGCCCGGCCCCAGGCTCTC

CCTGTCAGCGCCCGAAGGCCCTTCGCACCTCCAGGGGGCGCCGGCCTGCG

CGCACGCGCAATGGTCGCAGCCGCGTTCTCTTTAAGAGGACTCCTTTTGC

CTCCGCCGACCCCTTCGCTTCCGCTCCGCGTTCCCACAATGCAGTGCGGC

TGAGCGCCTCGGAGCCCGCGGGGACGCTGCGGGGGGACCCGTGCTGAggc

ggcggcggcgacgtgggctgcggcgggcccgcggcgtcgggcggtgcgga

tgtcgggctgggcggacgagcgcggcggcgAGGGCGACGGGCGCATCTAC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatGTGGGGAACC

TTCCGACCGACGTGCGCGAGAAGGACTTGGAGGACCTGTTCTACAAGTAC

GGCCGCATCCGCGAGATCGAGCTCAAGAACCGGCACGGCCTCGTGCCCTT

CGCCTTCGTGCGCTTCGAGGACCCCCGGTGAGGcccccgcgcccctgccc

tctcctcctcggtgcctgaggcccccgccttccctgctgtcccctccccc

agggctcccctccccccggcctcccctccccccgcctccgcgcagacccc

tcaCGGCGCCCCCTCACGGGTGGAGGATGAGGCAGCCTCTCCTCGCAGGC

CCGGGCCGTCCTTCGCGCCGTCGTCACTTCCTTTATTTTTATTATTCCAA

TATTTTACTTAGAAACCCAAAAGCTGAGCCTTTGGAGGGCCCAAGCCCGC

CTGCACCGGCCTCGGGGGGTCCAAATGAGCCTTGTCCGCC

(SEQ ID NO: 291)

pARBI-687:
TGTGGTGTGCTTTTCGAGAAAATGCTCACGAAGATTAGAAAAACACTGAT
2541

SRSF9_2_
GGTTTATTGGCAAAATCAATAATCTGTCAGCAGTTGATTCttttttttCT

Exogenous_68
CTGAATTAGCCCTCTTATGAGTAATCTGTTTGCTCATTCATTATAATTTC

ATACCTCTAAAACTGCGTGTGACAGCTGTAAAGGTTAATTCCAGTATCAT

GAAACGTCTCCAAACCAAAGCAGAAGTGCTTCAGGATCCTGATTTGTGTG

TTTTTTTCTTCACTCTAGGTTTCCCTTTTATGCTTACTACTCATGCCCCT

CACTTGGAAAGTCACTTGGCCTCCTGAACAGCACTAACTCCAAACGtttt

ttttgttgttgttgttttttttAGAGATGCAGAGGATGCTATTTATGGAA

GAAATGGTTATGATTATGGCCAGTGTCGGCTTCGTGTGGAGTTCCCCAGG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatACTTATGGAG

GTCGGGGTGGGTGGCCCCGTGGTGGGAGGAATGGGCCTCCTACAAGAAGA

TCTGATTTCCGAGTTCTTGTTTCAGGTATGTTCCTTTCAAACAGaatgag

atgatacatgtaaaatacttaacacagagtctgtcttccaagaaatgata

gctgttattcttCAGTGCATGGGACACGGGGGCTTTCTTTTCAATAGCCT

GTGTGAAGCCTTGCCCTGGATTGCCAATGAGGAAAGTATCCTGCAAATGA

AATTGCGCTGGGAGTGCAGCCTTGGAAGAACATAACCATATTTCTTGTAA

AGGAGTTTTCTAGTGGTGAGAAGGAAAGATGATGGGAAAACTTGAGCTAC

AATTCTAAAGATGCTTCTTTTGGAATATACTTGGCATCAGACATGGTAGA

AAGGCATTCAAGGAGCCAGATTTGAACAACTTACCCAGCC

(SEQ ID NO: 292)

pARBI-688:
GATGGCATCCACACGGCCCGGCCCCAGGCTCTCCCTGTCAGCGCCCGAAG
2541

SRSF9_3_
GCCCTTCGCACCTCCAGGGGGCGCCGGCCTGCGCGCACGCGCAATGGTCG

Exogenous_69
CAGCCGCGTTCTCTTTAAGAGGACTCCTTTTGCCTCCGCCGACCCCTTCG

CTTCCGCTCCGCGTTCCCACAATGCAGTGCGGCTGAGCGCCTCGGAGCCC

GCGGGGACGCTGCGGGGGGACCCGTGCTGAggcggcggcggcgacgtggg

ctgcggcgggcccgcggcgtcgggcggtgcggatgtcgggctgggcggac

gagcgcggcggcgAGGGCGACGGGCGCATCTACGTGGGGAACCTTCCGAC

CGACGTGCGCGAGAAGGACTTGGAGGACCTGTTCTACAAGTACGGCCGCA

TCCGCGAGATCGAGCTCAAGAACCGGCACGGCCTCGTGCCCTTCGCCTTC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatGTGCGCTTC

GAGGACCCCCGGTGAGGcccccgcgcccctgccctctcctcctcggtgcc

tgaggcccccgccttccctgctgtcccctcccccagggctcccctccccc

cggcctcccctccccccgcctccgcgcagacccctcaCGGCGCCCCCTCA

CGGGTGGAGGATGAGGCAGCCTCTCCTCGCAGGCCCGGGCCGTCCTTCGC

GCCGTCGTCACTTCCTTTATTTTTATTATTCCAATATTTTACTTAGAAAC

CCAAAAGCTGAGCCTTTGGAGGGCCCAAGCCCGCCTGCACCGGCCTCGGG

GGGTCCAAATGAGCCTTGTCCGCCTCCTGCCTGGGGCAGCACCGTAGGGG

GAAGCGGCCGCGGGGCAGCGCGGGGGTCGCCGTTCGCCCTTCCCGCTCGC

CTCTCCCCCGGCCCGTGCTCGCCGTGGCTGGAGAGCAAGCT

(SEQ ID NO: 293)

pARBI-689:
GTAACTGACTAGCCTTAGTAGACTGTGGTTTCCAGGTTTATTCAGAAGTA
2541

SUB1_1_
GCAAGATCCCTCCAtttttttttCTACCAAAGAAATCGTATGTGGGATCC

Exogenous_70
CAAACCACAAAATAACCGTTCCTGTGGTTAATACTACTATAATGCCTGAA

GTGTCTTTTGGGATCCTGAGAACAGAGTTTGAAAACATTACTAGACAGAA

GGATTGGTTAGATTCATAGTTTTGTTGTTGAGTGAAACTTGCTTATGTAT

ATATTTATGATATTTTGGATGTAGTCTTTTGATTGTTTAAATCTTAAAAA

GTAATGGGATCTTTTGACACTGGGGTATGTTTTATTTTTATGTGTGCAAA

TTTTAACCATATTCTTTTCTAGTTAAAGAGGAAAAAGCAAGTTGCTCCAG

AAAAACCTGTAAAGAAACAAAAGACAGGTGAGACTTCGAGAGCCCTGTCA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatTCTTCTAAAC

AGAGCAGCAGCAGCAGAGATGATAACATGTTTCAGGTAAAGTTGGCTAtt

ttttttttttttttttttgacatggagtcatgctctgtcacccaggctgg

agtgcagtggcgccatctcggctcactgcaacctcagcctcctgagttca

agcagttctctgcctcagcctcccgagtagctaggattacaggcatccgc

caccagacctggctaatttttgtatttttagtagagatggggtttcacca

tcttggccaggctggtcttgaactcctgaccttgtgatccaactgcctca

gcctccaaaagtgctgggtttacaggtgtgagccaccatgccttgccAAA

GTTGGCTGTTTCTTTAGATTCAGAGGAATTATTATCTGGCTTGATCTGAA

GAATGTTAAAAGTACTATGATCTGATAATTGCCTAATATG

(SEQ ID NO: 294)

pARBI-690:
ATAAATAAACATATCCTGGAAATGGAATAAGTTGGTTATATTCTTTTTAA
2541

SUB1_2_
TTAGTATATCTGCTTCGTAAAATAAGTAACTGACTAGCCTTAGTAGACTG

Exogenous_71
TGGTTTCCAGGTTTATTCAGAAGTAGCAAGATCCCTCCATTTTTTTTTCT

ACCAAAGAAATCGTATGTGGGATCCCAAACCACAAAATAACCGTTCCTGT

GGTTAATACTACTATAATGCCTGAAGTGTCTTTTGGGATCCTGAGAACAG

AGTTTGAAAACATTACTAGACAGAAGGATTGGTTAGATTCATAGTTTTGT

TGTTGAGTGAAACTTGCTTATGTATATATTTATGATATTTTGGATGTAGT

CTTTTGATTGTTTAAATCTTAAAAAGTAATGGGATCTTTTGACACTGGGG

TATGTTTTATTTTTATGTGTGCAAATTTTAACCATATTCTTTTCTAGTTA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatAAGAGGAAA

AAGCAAGTTGCTCCAGAAAAACCTGTAAAGAAACAAAAGACAGGTGAGAC

TTCGAGAGCCCTGTCATCTTCTAAACAGAGCAGCAGCAGCAGAGATGATA

ACATGTTTCAGGTAAAGTTGGCTATTTTTTTTTTTTTTTTTTTTGACATG

GAGTCATGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCCATCTCGGCTC

ACTGCAACCTCAGCCTCCTGAGTTCAAGCAGTTCTCTGCCTCAGCCTCCC

GAGTAGCTAGGATTACAGGCATCCGCCACCAGACCTGGCTAATTTTTGTA

TTTTTAGTAGAGATGGGGTTTCACCATCTTGGCCAGGCTGGTCTTGAACT

CCTGACCTTGTGATCCAACTGCCTCAGCCTCCAAAAGTGCTGGGTTTACA

GGTGTGAGCCACCATGCCTTGCCAAAGTTGGCTGTTTCTTT

(SEQ ID NO: 295)

pARBI-691:
AATTAGTATATCTGCTTCGTAAAATAAGTAACTGACTAGCCTTAGTAGAC
2541

SUB1_3_
TGTGGTTTCCAGGTTTATTCAGAAGTAGCAAGATCCCTCCATTTTTTTTT

Exogenous_72
CTACCAAAGAAATCGTATGTGGGATCCCAAACCACAAAATAACCGTTCCT

GTGGTTAATACTACTATAATGCCTGAAGTGTCTTTTGGGATCCTGAGAAC

AGAGTTTGAAAACATTACTAGACAGAAGGATTGGTTAGATTCATAGTTTT

GTTGTTGAGTGAAACTTGCTTATGTATATATTTATGATATTTTGGATGTA

GTCTTTTGATTGTTTAAATCTTAAAAAGTAATGGGATCTTTTGACACTGG

GGTATGTTTTATTTTTATGTGTGCAAATTTTAACCATATTCTTTTCTAGT

TAAAGAGGAAAAAGCAAGTTGCTCCAGAAAAACCTGTAAAGAAACAAAAG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatACAGGTGAG

ACTTCGAGAGCCCTGTCATCTTCTAAACAGAGCAGCAGCAGCAGAGATGA

TAACATGTTTCAGGTAAAGTTGGCTATTTTTTTTTTTTTTTTTTTTGACA

TGGAGTCATGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCCATCTCGGC

TCACTGCAACCTCAGCCTCCTGAGTTCAAGCAGTTCTCTGCCTCAGCCTC

CCGAGTAGCTAGGATTACAGGCATCCGCCACCAGACCTGGCTAATTTTTG

TATTTTTAGTAGAGATGGGGTTTCACCATCTTGGCCAGGCTGGTCTTGAA

CTCCTGACCTTGTGATCCAACTGCCTCAGCCTCCAAAAGTGCTGGGTTTA

CAGGTGTGAGCCACCATGCCTTGCCAAAGTTGGCTGTTTCTTTAGATTCA

GAGGAATTATTATCTGGCTTGATCTGAAGAATGTTAAAAGT

(SEQ ID NO: 296)

pARBI-692:
CACATTTTAATTTTTGTTTCCATGCTCTTTAGAATTCAACTAGAGGGCAG
2541

TET2_1_
CCTTGTGGATGGCCCCGAAGCAAGCCTGATGGAACAGGATAGAACCAACC

Exogenous_73
ATGTTGAGGGCAACAGACTAAGTCCATTCCTGATACCATCACCTCCCATT

TGCCAGACAGAACCTCTGGCTACAAAGCTCCAGAATGGAAGCCCACTGCC

TGAGAGAGCTCATCCAGAAGTAAATGGAGACACCAAGTGGCACTCTTTCA

AAAGTTATTATGGAATACCCTGTATGAAGGGAAGCCAGAATAGTCGTGTG

AGTCCTGACTTTACACAAGAAAGTAGAGGGTATTCCAAGTGTTTGCAAAA

TGGAGGAATAAAACGCACAGTTAGTGAACCTTCTCTCTCTGGGCTCCTTC

AGATCAAGAAATTGAAACAAGACCAAAAGGCTAATGGAGAAAGACGTAAC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatTTCGGGGTA

AGCCAAGAAAGAAATCCAGGTGAAAGCAGTCAACCAAATGTCTCCGATTT

GAGTGATAAGAAAGAATCTGTGAGTTCTGTAGCCCAAGAAAATGCAGTTA

AAGATTTCACCAGTTTTTCAACACATAACTGCAGTGGGCCTGAAAATCCA

GAGCTTCAGATTCTGAATGAGCAGGAGGGGAAAAGTGCTAATTACCATGA

CAAGAACATTGTATTACTTAAAAACAAGGCAGTGCTAATGCCTAATGGTG

CTACAGTTTCTGCCTCTTCCGTGGAACACACACATGGTGAACTCCTGGAA

AAAACACTGTCTCAATATTATCCAGATTGTGTTTCCATTGCGGTGCAGAA

AACCACATCTCACATAAATGCCATTAACAGTCAGGCTACTAATGAGTTGT

CCTGTGAGATCACTCACCCATCGCATACCTCAGGGCAGATC

(SEQ ID NO: 297)

pARBI-693:
AATGGAGAAAGACGTAACTTCGGGGTAAGCCAAGAAAGAAATCCAGGTGA
2541

TET2_2_
AAGCAGTCAACCAAATGTCTCCGATTTGAGTGATAAGAAAGAATCTGTGA

Exogenous_74
GTTCTGTAGCCCAAGAAAATGCAGTTAAAGATTTCACCAGTTTTTCAACA

CATAACTGCAGTGGGCCTGAAAATCCAGAGCTTCAGATTCTGAATGAGCA

GGAGGGGAAAAGTGCTAATTACCATGACAAGAACATTGTATTACTTAAAA

ACAAGGCAGTGCTAATGCCTAATGGTGCTACAGTTTCTGCCTCTTCCGTG

GAACACACACATGGTGAACTCCTGGAAAAAACACTGTCTCAATATTATCC

AGATTGTGTTTCCATTGCGGTGCAGAAAACCACATCTCACATAAATGCCA

TTAACAGTCAGGCTACTAATGAGTTGTCCTGTGAGATCACTCACCCATCG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatCATACCTCA

GGGCAGATCAATTCCGCACAGACCTCTAACTCTGAGCTGCCTCCAAAGCC

AGCTGCAGTGGTGAGTGAGGCCTGTGATGCTGATGATGCTGATAATGCCA

GTAAACTAGCTGCAATGCTAAATACCTGTTCCTTTCAGAAACCAGAACAA

CTACAACAACAAAAATCAGTTTTTGAGATATGCCCATCTCCTGCAGAAAA

TAACATCCAGGGAACCACAAAGCTAGCGTCTGGTGAAGAATTCTGTTCAG

GTTCCAGCAGCAATTTGCAAGCTCCTGGTGGCAGCTCTGAACGGTATTTA

AAACAAAATGAAATGAATGGTGCTTACTTCAAGCAAAGCTCAGTGTTCAC

TAAGGATTCCTTTTCTGCCACTACCACACCACCACCACCATCACAATTGC

TTCTTTCTCCCCCTCCTCCTCTTCCACAGGTTCCTCAGCTT

(SEQ ID NO: 298)

pARBI-694:
GGAAAAAGCACTCTGAATGGTGGAGTTTTAGAAGAACACCACCACTACCC
2541

TET2_3_
CAACCAAAGTAACACAACACTTTTAAGGGAAGTGAAAATAGAGGGTAAAC

Exogenous_75
CTGAGGCACCACCTTCCCAGAGTCCTAATCCATCTACACATGTATGCAGC

CCTTCTCCGATGCTTTCTGAAAGGCCTCAGAATAATTGTGTGAACAGGAA

TGACATACAGACTGCAGGGACAATGACTGTTCCATTGTGTTCTGAGAAAA

CAAGACCAATGTCAGAACACCTCAAGCATAACCCACCAATTTTTGGTAGC

AGTGGAGAGCTACAGGACAACTGCCAGCAGTTGATGAGAAACAAAGAGCA

AGAGATTCTGAAGGGTCGAGACAAGGAGCAAACACGAGATCTTGTGCCCC

CAACACAGCACTATCTGAAACCAGGATGGATTGAATTGAAGGCCCCTCGT

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatTTTCACCAAG

CGGAATCCCATCTAAAACGTAATGAGGCATCACTGCCATCAATTCTTCAG

TATCAACCCAATCTCTCCAATCAAATGACCTCCAAACAATACACTGGAAA

TTCCAACATGCCTGGGGGGCTCCCAAGGCAAGCTTACACCCAGAAAACAA

CACAGCTGGAGCACAAGTCACAAATGTACCAAGTTGAAATGAATCAAGGG

CAGTCCCAAGGTACAGTGGACCAACATCTCCAGTTCCAAAAACCCTCACA

CCAGGTGCACTTCTCCAAAACAGACCATTTACCAAAAGCTCATGTGCAGT

CACTGTGTGGCACTAGATTTCATTTTCAACAAAGAGCAGATTCCCAAACT

GAAAAACTTATGTCCCCAGTGTTGAAACAGCACTTGAATCAACAGGCTTC

AGAGACTGAGCCATTTTCAAACTCACACCTTTTGCAACAT

(SEQ ID NO: 299)

pARBI-695:
AAAGGGAGGTTGAGATGGGCTGAGGTCTTCTAGGAGGCGGGGAGGGAGTG
2541

TIGIT_1_
CAGCCTTGACAAGCCTCCCTGTGGGCGAGGTGTAAAGAGGGGCAGAAGTC

Exogenous_76
AGCTCTGGAAGCATAGGGCAGTGGGTGGGGAGGAGATGGGCTGGGCTGGG

CTGGAGTAGAGATGTGTGGAGAAGGGTGAGAAGACTGGAAAGACAACCTG

AATGGGGGACTGGGAGCCTTGAATAACAGGCATGGAGAGGAGCGTCTCTT

GAAATGGAAGAAACAGGAAATAATTACAGCCTCTATGGAGGAGCAACAGG

ATGGACTGGAGAAACTATCATTCCAAAATCCAGTTGGGGCCTCAAAGGCC

CTTAGAATTTTTCTAGGAAGGTTGAAGGCCAGCTGCTGACCCAGGACTCA

CATGTGCTTCGTCCTCTTCCCTAGGAATGATGACAGGCACAATAGAAACA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatACGGGGAAC

ATTTCTGCAGAGAAAGGTGGCTCTATCATCTTACAATGTCACCTCTCCTC

CACCACGGCACAAGTGACCCAGGTCAACTGGGAGCAGCAGGACCAGCTTC

TGGCCATTTGTAATGCTGACTTGGGGTGGCACATCTCCCCATCCTTCAAG

GATCGAGTGGCCCCAGGTCCCGGCCTGGGCCTCACCCTCCAGTCGCTGAC

CGTGAACGATACAGGGGAGTACTTCTGCATCTATCACACCTACCCTGATG

GGACGTACACTGGGAGAATCTTCCTGGAGGTCCTAGAAAGCTCAGGTATT

CCTGCTGGAGCAAGTTGGTGGATAAACCTCTCCCTCTAGCATAGAAAATG

CAATCCTGAAACACTGCACAGCAGGGCTTCTCAATTCGGGATCACATTTG

AATCACCTGAGGAGATTTTAAATCATACTGATGCCGAGGCC

(SEQ ID NO: 300)

pARBI-696:
GAGGAGATGGGCTGGGCTGGGCTGGAGTAGAGATGTGTGGAGAAGGGTGA
2541

TIGIT_2_
GAAGACTGGAAAGACAACCTGAATGGGGGACTGGGAGCCTTGAATAACAG

Exogenous_77
GCATGGAGAGGAGCGTCTCTTGAAATGGAAGAAACAGGAAATAATTACAG

CCTCTATGGAGGAGCAACAGGATGGACTGGAGAAACTATCATTCCAAAAT

CCAGTTGGGGCCTCAAAGGCCCTTAGAATTTTTCTAGGAAGGTTGAAGGC

CAGCTGCTGACCCAGGACTCACATGTGCTTCGTCCTCTTCCCTAGGAATG

ATGACAGGCACAATAGAAACAACGGGGAACATTTCTGCAGAGAAAGGTGG

CTCTATCATCTTACAATGTCACCTCTCCTCCACCACGGCACAAGTGACCC

AGGTCAACTGGGAGCAGCAGGACCAGCTTCTGGCCATTTGTAATGCTGAC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatTTGGGGTGG

CACATCTCCCCATCCTTCAAGGATCGAGTGGCCCCAGGTCCCGGCCTGGG

CCTCACCCTCCAGTCGCTGACCGTGAACGATACAGGGGAGTACTTCTGCA

TCTATCACACCTACCCTGATGGGACGTACACTGGGAGAATCTTCCTGGAG

GTCCTAGAAAGCTCAGGTATTCCTGCTGGAGCAAGTTGGTGGATAAACCT

CTCCCTCTAGCATAGAAAATGCAATCCTGAAACACTGCACAGCAGGGCTT

CTCAATTCGGGATCACATTTGAATCACCTGAGGAGATTTTAAATCATACT

GATGCCGAGGCCTCACCCAGACCAATTCAATCAGAATCCCTAATAGCAGA

GCTAAACAAGGGTAAGGTCTAAAAGCATTTCCAGGTGATTCTAATGGGCA

GCCAATACTGAGAACCACTGTTCTTATGTAAGAAGCACATC

(SEQ ID NO: 301)

pARBI-697:
CCTCCCTGTGGGCGAGGTGTAAAGAGGGGCAGAAGTCAGCTCTGGAAGCA
2541

TIGIT_3_
TAGGGCAGTGGGTGGGGAGGAGATGGGCTGGGCTGGGCTGGAGTAGAGAT

Exogenous_78
GTGTGGAGAAGGGTGAGAAGACTGGAAAGACAACCTGAATGGGGGACTGG

GAGCCTTGAATAACAGGCATGGAGAGGAGCGTCTCTTGAAATGGAAGAAA

CAGGAAATAATTACAGCCTCTATGGAGGAGCAACAGGATGGACTGGAGAA

ACTATCATTCCAAAATCCAGTTGGGGCCTCAAAGGCCCTTAGAATTTTTC

TAGGAAGGTTGAAGGCCAGCTGCTGACCCAGGACTCACATGTGCTTCGTC

CTCTTCCCTAGGAATGATGACAGGCACAATAGAAACAACGGGGAACATTT

CTGCAGAGAAAGGTGGCTCTATCATCTTACAATGTCACCTCTCCTCCACC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca

ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT

GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG

GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA

ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG

GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA

CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC

CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT

CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT

CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC

CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG

CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG

ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc

ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT

CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG

GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC

ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA

CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT

TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC

TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG

CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG

ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC

GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA

GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC

AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC

TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA

TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA

TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa

taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca

ttctagttgtggtttgtccaaactcatcaatgtatcttatACGGCACAAG

TGACCCAGGTCAACTGGGAGCAGCAGGACCAGCTTCTGGCCATTTGTAAT

GCTGACTTGGGGTGGCACATCTCCCCATCCTTCAAGGATCGAGTGGCCCC

AGGTCCCGGCCTGGGCCTCACCCTCCAGTCGCTGACCGTGAACGATACAG

GGGAGTACTTCTGCATCTATCACACCTACCCTGATGGGACGTACACTGGG

AGAATCTTCCTGGAGGTCCTAGAAAGCTCAGGTATTCCTGCTGGAGCAAG

TTGGTGGATAAACCTCTCCCTCTAGCATAGAAAATGCAATCCTGAAACAC

TGCACAGCAGGGCTTCTCAATTCGGGATCACATTTGAATCACCTGAGGAG

ATTTTAAATCATACTGATGCCGAGGCCTCACCCAGACCAATTCAATCAGA

ATCCCTAATAGCAGAGCTAAACAAGGGTAAGGTCTAAAAG

(SEQ ID NO: 302)

pARBI-698:
TAATGCCCAGCCTAAGTTGGGGAGACCACTCCAGATTCCAAGATGTACAG
2541

TRAC_1_
TTTGCTTTGCTGGGCCTTTTTCCCATGCCTGCCTTTACTCTGCCAGAGTT

Exogenous_79
ATATTGCTGGGGTTTTGAAGAAGATCCTATTAAATAAAAGAATAAGCAGT

ATTATTAAGTAGCCCTGCATTTCAGGTTTCCTTGAGTGGCAGGCCAGGCC

TGGCCGTGAACGTTCACTGAAATCATGGCCTCTTGGCCAAGATTGATAGC

TTGTGCCTGTCCCTGAGTCCCAGTCCATCACGAGCAGCTGGTTTCTAAGA

TGCTATTTCCCGTATAAAGCATGAGACCGTGACTTGCCAGCCCCACAGAG

CCCCGCCCTTGTCCATCACTGGCATCTGGACTCCAGCCTGGGTTGGGGCA

AAGAGGGAAATGAGATCATGTCCTAACCCTGATCCTCTTGTCCCACAGAT

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatATCCAGAAC

CCTGACCCTGCCGTGTACCAGCTGAGAGACTCTAAATCCAGTGACAAGTC

TGTCTGCCTATTCACCGATTTTGATTCTCAAACAAATGTGTCACAAAGTA

AGGATTCTGATGTGTATATCACAGACAAAACTGTGCTAGACATGAGGTCT

ATGGACTTCAAGAGCAACAGTGCTGTGGCCTGGAGCAACAAATCTGACTT

TGCATGTGCAAACGCCTTCAACAACAGCATTATTCCAGAAGACACCTTCT

TCCCCAGCCCAGGTAAGGGCAGCTTTGGTGCCTTCGCAGGCTGTTTCCTT

GCTTCAGGAATGGCCAGGTTCTGCCCAGAGCTCTGGTCAATGATGTCTAA

AACTCCTCTGATTGGTGGTCTCGGCCTTATCCATTGCCACCAAAACCCTC

TTTTTACTAAGAAACAGTGAGCCTTGTTCTGGCAGTCCAGA

(SEQ ID NO: 303)

pARBI-699:
GATTCCAAGATGTACAGTTTGCTTTGCTGGGCCTTTTTCCCATGCCTGCC
2541

TRAC_2_
TTTACTCTGCCAGAGTTATATTGCTGGGGTTTTGAAGAAGATCCTATTAA

Exogenous_80
ATAAAAGAATAAGCAGTATTATTAAGTAGCCCTGCATTTCAGGTTTCCTT

GAGTGGCAGGCCAGGCCTGGCCGTGAACGTTCACTGAAATCATGGCCTCT

TGGCCAAGATTGATAGCTTGTGCCTGTCCCTGAGTCCCAGTCCATCACGA

GCAGCTGGTTTCTAAGATGCTATTTCCCGTATAAAGCATGAGACCGTGAC

TTGCCAGCCCCACAGAGCCCCGCCCTTGTCCATCACTGGCATCTGGACTC

CAGCCTGGGTTGGGGCAAAGAGGGAAATGAGATCATGTCCTAACCCTGAT

CCTCTTGTCCCACAGATATCCAGAACCCTGACCCTGCCGTGTACCAGCTG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatAGAGACTCT

AAATCCAGTGACAAGTCTGTCTGCCTATTCACCGATTTTGATTCTCAAAC

AAATGTGTCACAAAGTAAGGATTCTGATGTGTATATCACAGACAAAACTG

TGCTAGACATGAGGTCTATGGACTTCAAGAGCAACAGTGCTGTGGCCTGG

AGCAACAAATCTGACTTTGCATGTGCAAACGCCTTCAACAACAGCATTAT

TCCAGAAGACACCTTCTTCCCCAGCCCAGGTAAGGGCAGCTTTGGTGCCT

TCGCAGGCTGTTTCCTTGCTTCAGGAATGGCCAGGTTCTGCCCAGAGCTC

TGGTCAATGATGTCTAAAACTCCTCTGATTGGTGGTCTCGGCCTTATCCA

TTGCCACCAAAACCCTCTTTTTACTAAGAAACAGTGAGCCTTGTTCTGGC

AGTCCAGAGAATGACACGGGAAAAAAGCAGATGAAGAGAAG

(SEQ ID NO: 304)

pARBI-700:
TTCCTGTGGTAGCGGAACTCACTAAGGGGCCCATCTGGACCCGAGGTATT
2541

TRAC_3_
GTGATGATAAATTCTGAGCACCTACCCCATCCCCAGAAGGGCTCAGAAAT

Exogenous_81
AAAATAAGAGCCAAGTCTAGTCGGTGTTTCCTGTCTTGAAACACAATACT

GTTGGCCCTGGAAGAATGCACAGAATCTGTTTGTAAGGGGATATGCACAG

AAGCTGCAAGGGACAGGAGGTGCAGGAGCTGCAGGCCTCCCCCACCCAGC

CTGCTCTGCCTTGGGGAAAACCGTGGGTGTGTCCTGCAGGCCATGCAGGC

CTGGGACATGCAAGCCCATAACCGCTGTGGCCTCTTGGTTTTACAGATAC

GAACCTAAACTTTCAAAACCTGTCAGTGATTGGGTTCCGAATCCTCCTCC

TGAAAGTGGCCGGGTTTAATCTGCTCATGACGCTGCGGCTGTGGTCCAGC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatTGAGGTGAG

GGGCCTTGAAGCTGGGAGTGGGGTTTAGGGACGCGGGTCTCTGGGTGCAT

CCTAAGCTCTGAGAGCAAACCTCCCTGCAGGGTCTTGCTTTTAAGTCCAA

AGCCTGAGCCCACCAAACTCTCCTACTTCTTCCTGTTACAAATTCCTCTT

GTGCAATAATAATGGCCTGAAACGCTGTAAAATATCCTCATTTCAGCCGC

CTCAGTTGCACTTCTCCCCTATGAGGTAGGAAGAACAGTTGTTTAGAAAC

GAAGAAACTGAGGCCCCACAGCTAATGAGTGGAGGAAGAGAGACACTTGT

GTACACCACATGCCTTGTGTTGTACTTCTCTCACCGTGTAACCTCCTCAT

GTCCTCTCTCCCCAGTACGGCTCTCTTAGCTCAGTAGAAAGAAGACATTA

CACTCATATTACACCCCAATCCTGGCTAGAGTCTCCGCACC

(SEQ ID NO: 305)

pARBI-701:
ATTATTAAGTAGCCCTGCATTTCAGGTTTCCTTGAGTGGCAGGCCAGGCC
2541

TRAC_4_
TGGCCGTGAACGTTCACTGAAATCATGGCCTCTTGGCCAAGATTGATAGC

Exogenous_82
TTGTGCCTGTCCCTGAGTCCCAGTCCATCACGAGCAGCTGGTTTCTAAGA

TGCTATTTCCCGTATAAAGCATGAGACCGTGACTTGCCAGCCCCACAGAG

CCCCGCCCTTGTCCATCACTGGCATCTGGACTCCAGCCTGGGTTGGGGCA

AAGAGGGAAATGAGATCATGTCCTAACCCTGATCCTCTTGTCCCACAGAT

ATCCAGAACCCTGACCCTGCCGTGTACCAGCTGAGAGACTCTAAATCCAG

TGACAAGTCTGTCTGCCTATTCACCGATTTTGATTCTCAAACAAATGTGT

CACAAAGTAAGGATTCTGATGTGTATATCACAGACAAAACTGTGCTAGAC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatATGAGGTCT

ATGGACTTCAAGAGCAACAGTGCTGTGGCCTGGAGCAACAAATCTGACTT

TGCATGTGCAAACGCCTTCAACAACAGCATTATTCCAGAAGACACCTTCT

TCCCCAGCCCAGGTAAGGGCAGCTTTGGTGCCTTCGCAGGCTGTTTCCTT

GCTTCAGGAATGGCCAGGTTCTGCCCAGAGCTCTGGTCAATGATGTCTAA

AACTCCTCTGATTGGTGGTCTCGGCCTTATCCATTGCCACCAAAACCCTC

TTTTTACTAAGAAACAGTGAGCCTTGTTCTGGCAGTCCAGAGAATGACAC

GGGAAAAAAGCAGATGAAGAGAAGGTGGCAGGAGAGGGCACGTGGCCCAG

CCTCAGTCTCTCCAACTGAGTTCCTGCCTGCCTGCCTTTGCTCAGACTGT

TTGCCCCTTACTGCTCTTCTAGGCCTCATTCTAAGCCCCTT

(SEQ ID NO: 306)

pARBI-702:
TTCATTTCCATTTGAGTTGTTCTTATTGAGTCATCCTTCCTGTGGTAGCG
2541

TRAC_6_
GAACTCACTAAGGGGCCCATCTGGACCCGAGGTATTGTGATGATAAATTC

Exogenous_84
TGAGCACCTACCCCATCCCCAGAAGGGCTCAGAAATAAAATAAGAGCCAA

GTCTAGTCGGTGTTTCCTGTCTTGAAACACAATACTGTTGGCCCTGGAAG

AATGCACAGAATCTGTTTGTAAGGGGATATGCACAGAAGCTGCAAGGGAC

AGGAGGTGCAGGAGCTGCAGGCCTCCCCCACCCAGCCTGCTCTGCCTTGG

GGAAAACCGTGGGTGTGTCCTGCAGGCCATGCAGGCCTGGGACATGCAAG

CCCATAACCGCTGTGGCCTCTTGGTTTTACAGATACGAACCTAAACTTTC

AAAACCTGTCAGTGATTGGGTTCCGAATCCTCCTCCTGAAAGTGGCCGGG

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatTTTAATCTG

CTCATGACGCTGCGGCTGTGGTCCAGCTGAGGTGAGGGGCCTTGAAGCTG

GGAGTGGGGTTTAGGGACGCGGGTCTCTGGGTGCATCCTAAGCTCTGAGA

GCAAACCTCCCTGCAGGGTCTTGCTTTTAAGTCCAAAGCCTGAGCCCACC

AAACTCTCCTACTTCTTCCTGTTACAAATTCCTCTTGTGCAATAATAATG

GCCTGAAACGCTGTAAAATATCCTCATTTCAGCCGCCTCAGTTGCACTTC

TCCCCTATGAGGTAGGAAGAACAGTTGTTTAGAAACGAAGAAACTGAGGC

CCCACAGCTAATGAGTGGAGGAAGAGAGACACTTGTGTACACCACATGCC

TTGTGTTGTACTTCTCTCACCGTGTAACCTCCTCATGTCCTCTCTCCCCA

GTACGGCTCTCTTAGCTCAGTAGAAAGAAGACATTACACTC

(SEQ ID NO: 307)

pARBI-703:
CAGTCCATCACGAGCAGCTGGTTTCTAAGATGCTATTTCCCGTATAAAGC
2541

TRAC_
ATGAGACCGTGACTTGCCAGCCCCACAGAGCCCCGCCCTTGTCCATCACT

Exogenous_83
GGCATCTGGACTCCAGCCTGGGTTGGGGCAAAGAGGGAAATGAGATCATG

TCCTAACCCTGATCCTCTTGTCCCACAGATATCCAGAACCCTGACCCTGC

CGTGTACCAGCTGAGAGACTCTAAATCCAGTGACAAGTCTGTCTGCCTAT

TCACCGATTTTGATTCTCAAACAAATGTGTCACAAAGTAAGGATTCTGAT

GTGTATATCACAGACAAAACTGTGCTAGACATGAGGTCTATGGACTTCAA

GAGCAACAGTGCTGTGGCCTGGAGCAACAAATCTGACTTTGCATGTGCAA

ACGCCTTCAACAACAGCATTATTCCAGAAGACACCTTCTTCCCCAGCCCA

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatGGTAAGGGC

AGCTTTGGTGCCTTCGCAGGCTGTTTCCTTGCTTCAGGAATGGCCAGGTT

CTGCCCAGAGCTCTGGTCAATGATGTCTAAAACTCCTCTGATTGGTGGTC

TCGGCCTTATCCATTGCCACCAAAACCCTCTTTTTACTAAGAAACAGTGA

GCCTTGTTCTGGCAGTCCAGAGAATGACACGGGAAAAAAGCAGATGAAGA

GAAGGTGGCAGGAGAGGGCACGTGGCCCAGCCTCAGTCTCTCCAACTGAG

TTCCTGCCTGCCTGCCTTTGCTCAGACTGTTTGCCCCTTACTGCTCTTCT

AGGCCTCATTCTAAGCCCCTTCTCCAAGTTGCCTCTCCTTATTTCTCCCT

GTCTGCCAAAAAATCTTTCCCAGCTCACTAAGTCAGTCTCACGCAGTCAC

TCATTAACCCACCAATCACTGATTGTGCCGGCACATGAATG

(SEQ ID NO: 308)

pARBI-704:
TGAGGAAGAAGCGCGGGCGGCGCCTTCGGGAGGCGAGCAGGCAGCAGTTG
2541

TRIM28_1_
GCCGTGCCGTAGCAGCGTCCCGCGCGCGGCGGGCAGCGGCCCAGGAGGCG

Exogenous_85
CGTGGCGGCGCTCGGCCTCGCGGCGGCGGCGGCGGCAGCGGCCCAGCAGT

TGGCGGCGAGCGCGTCTGCGCCTGCGCGGCGGGCCCCGCGCCCCTCCTCC

CCCCCTGGGCGCCCCCGGCGGCGTGTGAATGGCGGCCTCCGCGGCGGCAG

CCTCGGCAGCAGCGGCCTCGGCCGCCTCTGGCAGCCCGGGCCCGGGCGAG

GGCTCCGCTGGCGGCGAAAAGCGCTCCACCGCCCCTTCGGCCGCAGCCTC

GGCCTCTGCCTCAGCCGCGGCGTCGTCGCCCGCGGGGGGCGGCGCCGAGG

CGCTGGAGCTGCTGGAGCACTGCGGCGTGTGCAGAGAGCGCCTGCGACCC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatGAGAGGGAG

CCCCGCCTGCTGCCCTGTTTGCACTCGGCCTGTAGTGCCTGCTTAGGGCC

CGCGGCCCCCGCCGCCGCCAACAGCTCGGGGGACGGCGGGGCGGCGGGCG

ACGGCACCGGTAAGTACGAAGTGATCGGTGCCACCCCTCCCCCTACTCTC

TGCCTTTGATTCCGACTGGGTGCAGAGATGAGGATGCCACCTGGGCGAGA

GGATGGGGGCCCGGACAGGGCACGGGAAATACTTTCTGGGTCCTGCATAC

GAACGTGGGTTTGTGCTGGCCGCTGAGATGGGACATCTGACTAAAGTTGG

AGAAAAGAAGGCTCGGGGAGGGGAGGGGCTGGTTCGCTGCGGGATAATGG

TCGGGGGCCCACCCAGCAGGGGAATGGTGGGGGCCATAACCTGGGTGGGA

ACTTGTAACAGTCTCCCACATCCCTGCTTCTCGAAGTGGTG

(SEQ ID NO: 309)

pARBI-705:
TCGAAGTGGTGGACTGTCCCGTGTGCAAGCAACAGTGCTTCTCCAAAGAC
2541

TRIM28_2_
ATCGTGGAGAATTATTTCATGCGTGATAGTGGCAGCAAGGCTGCCACCGA

Exogenous_86
CGCCCAGGATGCGAACCAGGTGCGTCCTATCTCAGCAACCACAAGGAGGT

TTCTGGGGAGGGGGCATCTGCGCAGGAGGAGCTTGGCACCAGCTCCAGGC

TGTTACTCCACTTTCCCAAGGCTCTGGGTGGGCTGCCTAGGTTGGGTCAA

GGGACCAATCTTAAATCTCCGGTTGTATTTTCTGGGATGTAAACGTGGAT

CTATCAAGTIGTCTTGCCTTCTCTGACCCTGCCTTTGTCTGGCAGTGCTG

CACTAGCTGTGAGGATAATGCCCCAGCCACCAGCTACTGTGTGGAGTGCT

CGGAGCCTCTGTGTGAGACCTGTGTAGAGGCGCACCAGCGGGTGAAGTAC

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatACCAAGGAC

CATACTGTGCGCTCTACTGGTACATGAGGCTGAGGGGGGCTGTTGGAGTT

GTTCTCCCATGTGTGCCCTCAGTTGCTTTTATGATGTTGGTTGCATCTGG

TGGATGGGTCCTAGAGTTCTCTAGGGGGTGCCGCCCGAAGGGCCCGAGGG

CAGAACTCCAGAAGCAGAAAAACTGGGGTTGTGGTGTGTAGTCTCTAGGG

CCTAGGTGGGAGAGGGTGGGAAGGGGAAATAAGGGAGACCTTAATGTGCT

GCAGGGAGGTACAAAGGGTTTGAGAAGGCTTATCAGGGAGTTGTCAGACC

TGGTGGTGAAGGGCTCAGCATATGCAAACAGGGAAAGGCATGGTGTGAAG

GGCTTTCTGGGTTTGTGGTTCCCTGGCACACATCTGGTATAAGATGCTGC

TAGGGAAAGTAGACTGTGGGTCCATGGATTATAAGTGATGA

(SEQ ID NO: 310)

pARBI-706:
GGCGCCCAATGCGCGTGCGCGGCGGCGTCGGCGCCAGTTATTTCTGTCCC
2541

TRIM28_3_
GCCCCCCGGCCTCGGCTCTTTCTGCGAGCGGGCGCGCGGGCGAGCGGTTG

Exogenous_87
TGCTTGTGCTTGTGGCGCGTGGTGCGGGTTTCGGCGGCGGCTGAGGAAGA

AGCGCGGGCGGCGCCTTCGGGAGGCGAGCAGGCAGCAGTTGGCCGTGCCG

TAGCAGCGTCCCGCGCGCGGCGGGCAGCGGCCCAGGAGGCGCGTGGCGGC

GCTCGGCCTCGCGGCGGCGGCGGCGGCAGCGGCCCAGCAGTTGGCGGCGA

GCGCGTCTGCGCCTGCGCGGCGGGCCCCGCGCCCCTCCTCCCCCCCTGGG

CGCCCCCGGCGGCGTGTGAATGGCGGCCTCCGCGGCGGCAGCCTCGGCAG

CAGCGGCCTCGGCCGCCTCTGGCAGCCCGGGCCCGGGCGAGGGCTCCGCT

tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc

gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata

aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg

ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc

aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG

TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG

GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA

AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG

GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA

ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT

CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG

TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG

TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC

CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT

GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA

GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac

cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG

TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG

GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC

CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT

ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC

TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT

CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG

GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG

GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA

CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA

AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC

CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA

CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG

ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC

ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa

ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc

attctagttgtggtttgtccaaactcatcaatgtatcttatGGCGGCGAA

AAGCGCTCCACCGCCCCTTCGGCCGCAGCCTCGGCCTCTGCCTCAGCCGC

GGCGTCGTCGCCCGCGGGGGGCGGCGCCGAGGCGCTGGAGCTGCTGGAGC

ACTGCGGCGTGTGCAGAGAGCGCCTGCGACCCGAGAGGGAGCCCCGCCTG

CTGCCCTGTTTGCACTCGGCCTGTAGTGCCTGCTTAGGGCCCGCGGCCCC

CGCCGCCGCCAACAGCTCGGGGGACGGCGGGGCGGCGGGCGACGGCACCG

GTAAGTACGAAGTGATCGGTGCCACCCCTCCCCCTACTCTCTGCCTTTGA

TTCCGACTGGGTGCAGAGATGAGGATGCCACCTGGGCGAGAGGATGGGGG

CCCGGACAGGGCACGGGAAATACTTTCTGGGTCCTGCATACGAACGTGGG

TTTGTGCTGGCCGCTGAGATGGGACATCTGACTAAAGTTGG

(SEQ ID NO: 311)

	Number	Date	Country
	63141926	Jan 2021	US
	63105834	Oct 2020	US

	Number	Date	Country
Parent	17716816	Apr 2022	US
Child	18453801		US
Parent	17239484	Apr 2021	US
Child	17716816		US

SAFE HARBOR LOCI

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Date Filed

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CPC

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Abstract

Description

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CROSS REFERENCE TO RELATED APPLICATIONS

Provisional Applications (2)

Divisions (2)