Claims
- 1. A polyvalent metal salt of a salicylic acid derivative represented by the formula (1): ##STR9## wherein X.sub.1 and X.sub.2 are a hydrogen atom, an alkyl group, an alkoxy group, an aralkyl group, an aryl group or a halogen atom, Y.sub.1 and Y.sub.2 are an oxygen atom or a sulfur atom, R.sub.1 is a hydrogen atom, an alkyl group, an aralkyl group or an aryl group, and R.sub.2 is an alkyl group, an alkenyl group, an aralkyl group or an aryl group: with the proviso that when X.sub.1, X.sub.2 and R.sub.1 each are a hydrogen atom, Y.sub.1 and Y.sub.2 both are an oxygen atom and R.sub.2 is ethyl, the metal salt is not the calcium salt.
- 2. The metal salt of claim 1 wherein X.sub.1 and X.sub.2 are a hydrogen atom and R.sub.1 is a hydrogen atom.
- 3. The metal salt of claim 1 wherein the metal salt is selected from the group consisting of a zinc, magnesium, calcium, barium, nickel, manganese, cobalt and aluminum salt.
- 4. The metal salt of claim 2 wherein the metal salt is selected from the group consisting of a zinc, magnesium, calcium, barium, nickel, manganese, cobalt and aluminum salt.
- 5. A process for preparing a salicylic acid derivative represented by the formula (1): ##STR10## wherein X.sub.1 and X.sub.2 are a hydrogen atom, an alkyl group, an alkoxy group, an aralkyl group, an aryl group or a halogen atom, Y.sub.1 and Y.sub.2 are an oxygen atom or a sulfur atom, R.sub.1 is a hydrogen atom, an alkyl group, an aralkyl group or an aryl group , and R.sub.2 is an alkyl group, an alkenyl group, an aralkyl group or an aryl group, comprising reacting a compound represented by the formula (2): ##STR11## wherein X, X.sub.2 and R.sub.1 are the same as above, with a compound represented by the formula (3): ##STR12## wherein Y.sub.1, Y.sub.2 and R.sub.2 are the same as above and Z is a halogen atom, in the presence of an alcohol-based solvent.
- 6. A process for preparing a polyvalent metal salt of a salicylic acid derivative represented by the formula (1): ##STR13## wherein X.sub.1 and X.sub.2 are a hydrogen atom, an alkyl group, an alkoxy group, an aralkyl group, an aryl group or a halogen atom, Y.sub.1 and Y.sub.2 are an oxygen atom or a sulfur atom, R.sub.1 is a hydrogen atom, an alkyl group, an aralkyl group or an aryl group , and R.sub.2 is an alkyl group, an alkenyl group, an aralkyl group or an aryl group, comprising reacting a compound represented by the formula (2): ##STR14## wherein X.sub.1, X.sub.2 and R.sub.1 are the same as above, with a compound represented by the formula (3): ##STR15## wherein Y.sub.1, Y.sub.2 and R.sub.2 are the same as above and Z is a halogen atom, in the presence of an alcohol-based solvent, treating the resultant salicylic acid derivative represented by the formula (1) with an alkali metal salt, and carrying out a double decomposition reaction of the resulting alkali metal salt of the salicylic acid derivative in an aqueous solution with a water soluble compound of a metal having from 2 to 4 valence.
- 7. The metal salt of claim 1 wherein X.sub.1, X.sub.2 and R.sub.1 each are a hydrogen atom, Y.sub.1 and Y.sub.2 each are an oxygen atom and the metal salt is the zinc salt.
- 8. The metal salt of claim 1 wherein R.sub.2 is alkyl having from 3 to 24 carbon atoms, nonsubstituted or substituted alkenyl having from 2 to 24 carbon atoms, nonsubstituted or substituted aralkyl having from 7 to 24 carbon atoms, or nonsubstituted aryl having from 6 to 24 carbon atoms.
- 9. The metal salt of claim 1 wherein R.sub.2 is n-octyl, n-decyl or phenyl.
- 10. The process of claim 5 wherein R.sub.2 is alkyl having from 3 to 24 carbon atoms, nonsubstituted or substituted alkenyl having from 2 to 24 carbon atoms, nonsubstituted or substituted aralkyl having from 7 to 24 carbon atoms, or nonsubstituted aryl having from 6 to 24 carbon atoms.
- 11. The process of claim 5 wherein X.sub.1, X.sub.2 and R.sub.1 each are a hydrogen atom, Y.sub.1 and Y.sub.2 each are an oxygen atom and the metal salt is the zinc salt.
- 12. The process of claim 5 wherein R.sub.2 is n-octyl, n-decyl or phenyl.
- 13. The process of claim 6 wherein R.sub.2 is alkyl having from 3 to 24 carbon atoms, nonsubstituted or substituted alkenyl having from 2 to 24 carbon atoms, nonsubstituted or substituted aralkyl having from 7 to 24 carbon atoms, or nonsubstituted aryl having from 6 to 24 carbon atoms.
- 14. The process of claim 6 wherein X.sub.1, X.sub.2 and R.sub.1 each are a hydrogen atom, Y.sub.1 and Y.sub.2 each are an oxygen atom and the metal salt is the zinc salt.
- 15. The process of claim 6 wherein R.sub.2 is n-octyl, n-decyl or phenyl.
Priority Claims (2)
| Number |
Date |
Country |
Kind |
| 3-243201 |
Sep 1991 |
JPX |
|
| 4-168744 |
Jun 1992 |
JPX |
|
CROSS-REFERENCE TO RELATED APPLICATION
This is a continuation of application Ser. No. 08/301,428, filed Sep. 9, 1994, now abandoned, filed as a continuation-in-part of application Ser. No. 08/108,500, now U.S. Pat. No. 5,346,878 filed Aug. 18, 1993, as a continuation-in-part of application Ser. No. 07/946,694, filed Sep. 18, 1992, now U.S. Pat. No. 5,306,688, whose disclosures are incorporated herein by reference.
US Referenced Citations (6)
Foreign Referenced Citations (3)
| Number |
Date |
Country |
| 0253666 |
Jan 1988 |
EPX |
| 0534257 |
Mar 1993 |
EPX |
| 0263037 |
Jan 1949 |
CHX |
Non-Patent Literature Citations (2)
| Entry |
| CRC Handbook of Chemistry and Physics, 63rd Ed., CRC Press pp. C-508 (1982-1983). |
| Baker et al., Journal of Pharmaceutical Sciences, vol. 52, No. 10, pp. 927-933 (1963). |
Continuations (1)
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Number |
Date |
Country |
| Parent |
301428 |
Sep 1994 |
|
Continuation in Parts (2)
|
Number |
Date |
Country |
| Parent |
108500 |
Aug 1993 |
|
| Parent |
946694 |
Sep 1992 |
|
Patent Grant
5476957
