Patent Application
20120177548
The present invention relates generally to sample preprocessing systems that automatically preprocess blood, urine, and other biological samples prior to analysis, and more particularly, to a sample preprocessing system equipped with a centrifuge unit for centrifuging samples.
Sample preprocessing systems are designed so that when supplied with blood, urine, or other biological samples previously taken from patients, the system automatically conducts centrifuging, decapping, dispensing, sorting, conveying, and other processes, upon the samples.
A scheme of carrying samples in such a sample preprocessing system commonly uses either carriers each loaded with a plurality of samples, or carriers each loaded with one sample container.
In the carrying scheme that uses carriers each loaded with a plurality of samples, the samples are loaded into the sample preprocessing system by means of the carriers. In this scheme, shapes of the sample containers on the same carrier, and the kinds of samples used have needed to be unified, which in turn has required processing with an apparatus represented by those described in Patent Document 1 or 2, as well as an operator's manual intervention.
On the other hand, in the carrying scheme that uses carriers each loaded with one sample container, upon samples being loaded in a tray-rested condition into the sample preprocessing system, the samples are each transferred from the tray to a carrier in fixed order automatically. This has eliminated the need to unify the shapes of the sample containers and the kinds of samples, because of the carrier being loaded with one sample only.
In the above scheme, however, a succession of samples different in the type of processing required may reach various processing units. If a group consisting of a plurality of samples includes samples different in the type of processing required, this does not enable collective, simultaneous processing of the samples, even by a unit capable of processing samples collectively as a group. A need arises, therefore, to subgroup the samples and repeat processing a plurality of times.
As a result, the sample preprocessing system decreases in throughput that is more or less affected by a manner of arranging the samples on the trays supplied.
Prior Art Literature
Patent Documents
Patent Document 1: JP-5-142232-A
Patent Document 1: JP-2007-40880-A
Provided is a sample preprocessing system of a carrier conveying scheme, neither requiring an operator's manual intervention nor suffering a decrease in throughput due to a manner of arranging samples on trays supplied.
Of a plurality of processing units included in the sample preprocessing system, a centrifuge unit positioned at an upstream process site to process a plurality of samples in a collective manner includes control means that changes transfer order for feeding out centrifuged samples from order for transferring the samples into the centrifuge unit. This change of the transfer order prevents a decrease in throughput of the processing units positioned at downstream process sites.
The present invention has a beneficial effect in that it prevents the decrease in the throughput of the sample preprocessing system without requiring an apparatus represented by those described in Patent Document 1 or 2, as well as an operator's manual intervention.
The present invention has another beneficial effect in that it prevents a decrease in throughput of analyzers connected via connection lines.
Hereunder, the present invention will be described in detail using an embodiment.
The carrier loaded with samples is carried from the loading unit 205 to a centrifuge unit 207 using a conveyance line 203.
Referring to
Next, a samples processing sequence in the centrifuge unit 207 is described below. A samples-loaded carrier that has been carried to the centrifuge unit 207 is further carried to the centrifugation-queued sample retaining unit 306 by the conveyance line 203. The sample handling mechanism 304 extracts the samples from the carrier in the sample retaining unit 306, and then the samples are transferred to the adapters 305 on the adapter retaining unit 302. The information that has been stored into the controller 201 in order to indicate which carrier is loaded with which samples is erased upon completion of the transfer. A historical record of which carrier has been loaded with which samples, however, is saved without being erased. The carrier from which the samples have been extracted is carried to the centrifuged sample retaining unit 307, whereby the carrier can then be loaded with other samples.
After that, samples that have been carried to the centrifuge unit 207 are likewise transferred to the adapters 305 on the adapter retaining unit 302. The transfer of the samples is repeated for a specified time or until four adapters 305 have become full of centrifugation-queued samples. Upon completion of the transfer, each adapter 305 is transferred to the centrifuging mechanism 303, in which, centrifugal separation is started.
After centrifugation, each sample becomes ready for carrier loading at the centrifuged sample retaining unit 307 via the adapter retaining unit 302.
In a conventional system, a carrier in a centrifuged sample retaining unit 307 has been loaded with carrier-loadable samples by a centrifuge unit 207 in the same order as that in which a sample handling mechanism 304 had extracted the samples from the carrier.
The carrier-loaded samples have been decapped in a decapping unit 208 and then carried to a dispensing unit 209.
In the present invention, however, order of carrier loading with samples is changed. The following describes a carrier-loading order changing sequence.
Registered in the controller 201 are analytical item registration information that denotes analysis items which the analyzers 211, 212, and 213 can execute, analyzability attribute information that denotes whether the analysis items can each be executed from one child sample, priority level information on samples, and analysis request information. The child sample is a sample that the dispensing unit 209 generates by dispensing a supplied sample. If the analyzability attribute information differs between analytical items, a plurality of child samples are generated.
The controller 201 also provides a screen menu shown in
Data that is entered in the menu will be used during carrier-loading order determination based on a process flow of
Each time a sample is transferred to one adapter 305 on the adapter retaining unit 302, which sample has been transferred to which adapter 305 is stored in time series into the centrifuge unit 207.
First, presence/absence of a loading order change is determined in loading-order change existence determination step 501, and if the change is present and ineffective, loading order determination step 514 relating to all samples is executed in accordance with the order information 402, that is, in the order that the samples were transferred to the adapters 305.
If the change is effective, whether loading order of an urgent sample is to be preferentially set is determined in urgent-sample loading-order change existence determination step 502, and the determination is followed by loading-order determination step 511 for the urgent sample. In urgent-sample loading order determination step 511, the loading order of the urgent sample only is determined in accordance with the order information 402 denoting the order of transfer to an adapter 305.
Analyzability attribute information on samples whose carrier loading order has not been determined is viewed and how many analyzability attribute information patterns exist and how many samples corresponding to each pattern exist are compiled in analyzability attribute information compiling step 503. If the carrier loading order of the urgent sample has already been determined, this compiling step is executed only for non-urgent samples. If the carrier loading order of the urgent sample is undetermined, the compiling step is executed for all samples including the urgent sample.
Next, analyzability attribute information rearranging step 504 is executed to rearrange the obtained analyzability attribute information patterns in descending order of magnitude of the number of samples corresponding to the pattern. Analyzability attribute information updating step 505 for samples selection next follows to extract the patterns, one at a time, in order. In analyzability attribute information updating step 505, operational states of the analyzers connected via connection lines 210 may be considered during the extraction of each analyzability attribute information pattern.
In step 506 of selecting analyzability attribute information matching samples, samples with an analyzability attribute information pattern that matches the extracted pattern are selected. In order to complete the analyses corresponding to the samples analysis request information, the system executes samples grouping step 507 to sort out all selected samples into groups for each analyzer to which the sample is to be carried. The sorting is based on analysis item registration information.
In grouped-samples loading order determination step 508, loading order of the samples contained in the group is determined in accordance with the order information 402 denoting the order of transfer to the adapters 305.
If the loading order of all samples is not yet determined, the process returns from all-samples loading-order determination end checking step 509 to analyzability attribute information updating step 505, in which step, the analyzability attribute information pattern to be used for samples selection is then updated into the analyzability attribute information pattern that is next largest in the number of corresponding samples. Analyzability attribute information matching samples selection step 506 onward is repeated after that.
If the loading order of all samples is already determined, order of loading from adapters to a carrier is indicated to the centrifuge unit 207 in step 510 of indicating the adapter-to-carrier loading order to the centrifuge unit 207.
After this, upon completion of centrifugation, the samples are loaded onto the carrier in the centrifuged sample retaining unit 307 by the centrifuge unit 207 in the order specified from the controller 201. After the transfer of each sample to the carrier, the ID reading means reads the sample identification code assigned to the sample, and the carrier identification code assigned to the carrier. Thus, which carrier is loaded with which samples are registered in the controller 201 once again.
In this way, in the centrifuge unit 207 positioned at an upstream process site relative to the plurality of processing units included in the sample preprocessing system, the order for feeding out the samples from the centrifuge unit 207 upon completion of centrifugation is changed from the order in which the samples have been transferred into the centrifuge unit 207 prior to the centrifugation. Throughput of the processing units positioned at downstream process sites can therefore be prevented from decreasing.
In addition, since child samples that will be conveyed via the same path are continuously created in the dispensing unit 209, throughput of the analyzers connected via the connection lines 210 can also be prevented from decreasing.
Although this is not described in the present example, when carrier loading order of urgent samples is determined in urgent-sample loading order determination step 511 of
Description of Reference Numbers
| Number | Date | Country | Kind |
|---|---|---|---|
| 2009-225917 | Sep 2009 | JP | national |
| Filing Document | Filing Date | Country | Kind | 371c Date |
|---|---|---|---|---|
| PCT/JP10/05158 | 8/23/2010 | WO | 00 | 2/7/2012 |
