The present disclosure relates to sanitary fittings or ports, typically for use with sealed chemical bags in the chemical/biochemical/pharmaceutical manufacturing industries.
Sterility is a large concern in certain fields, such as biopharmaceutical manufacturing. Many different chemicals, both dry and in solution, may be used during the manufacturing process. Often such chemicals are provided in hermetically sealed bags. Providing sealable sanitary fittings with ports allowing access to the interior portion of a sealed bag enables a sterile environment within the bag to be maintained while allowing the contents of the bag to be emptied.
Sanitary fittings are typically composed of a connector portion that defines a fluid flow path and provides a structure for attachment to fluid tubing of a connector and a flange portion that is hermetically sealed to the bag. Sanitary fittings may be joined to bags in several ways, most commonly through welding processes. The flange portion used to secure the port to the bag is first mated to the bag, and a heating element or RF welding fixture melts (welds) the bag to the flange. This weld is made to be impermeable, which maintains sterility within the bag. Once the bag is joined to the sanitary fitting, materials can be transferred through the port portion of the sanitary fitting into and out of the bag while maintaining this sterility.
The information included in this Background section of the specification, including any references cited herein and any description or discussion thereof, is included for technical reference purposes only and is not to be regarded subject matter by which the scope of the invention as defined in the claims is to be bound.
Sanitary fittings are disclosed herein that maintain sterility and allow contents to be drained as quickly as possible by providing sanitary fitting ports with port entrance features and/or geometries that encourage optimal flow of the bag contents.
In one implementation, a sanitary fitting may have a flange portion, a connector portion, and a parabolic entrance disposed therebetween. The flange portion may have a planar ring surface that defines a central opening. The connector portion may define a lumen extending from the central opening toward an outlet port. The parabolic entrance surface extends from the planar ring surface and transitions into the connector portion to define a portion of the lumen.
In another implementation, a sanitary fitting may have a flange portion, a connector portion, a parabolic entrance disposed therebetween, and a suction-relief rib. The flange portion may define a flat face and a central opening therein. The connector portion extends from the flange portion and defines an outlet port. The parabolic entrance to the outlet port may be formed by a continuous sidewall that defines the central opening extending from an inner perimeter edge of the flat face to the outlet port of the connector portion. The suction-relief rib may be arranged along the flat face of the flange portion and extend into the parabolic entrance. The suction-relief rib may have a twisting curvature for causing rotation of fluid flow through the sanitary fitting.
In a further implementation, a sanitary fitting may have a flange portion, a connector portion extending from the flange portion and defining a lumen therethrough, and a plurality of suction-relief ribs positioned on the flange portion around an entrance opening to the lumen and configured to cause a vortex in fluid flow through the lumen.
This Summary is provided to introduce a selection of concepts in a simplified form that are further described below in the Detailed Description. This Summary is not intended to identify key features or essential features of the claimed subject matter, nor is it intended to be used to limit the scope of the claimed subject matter. A more extensive presentation of features, details, utilities, and advantages of the present invention is provided in the following written description of various embodiments of the invention, illustrated in the accompanying drawings, and defined in the appended claims.
Sanitary fittings as disclosed may be used in the sterile transfer materials. The sanitary fittings may include a parabolic lead-in geometry between a flange portion and a port portion and vortex-forming suction-relief ribs on the flange portion, the connector portion, or both, and each may facilitate optimal material flow through the sanitary fitting. The sanitary fittings may be configured as ports for receptacles such as bags and containers in sterile settings such as in the pharmaceutical industry. In some implementations, the connector portions of the sanitary fittings may be configured as hose barbs, reducers, or as ferrules.
Parabolic Lead-In
The flange portion 4 of the sanitary fitting 2 maybe configured as a planar structure with a circular outer circumference 5 and may define planar ring 8 defining a central opening 9 extending through the flange portion 4 from a flat face 10 of the flange portion 4 to a connector mating side 12 of the flange portion 4.
The connector portion 6 of the sanitary fitting 2 may be configured as a cylindrical wall 14 that defines a lumen 18. The connector portion 6 may join or be integrally formed with the flange portion 4 as the connector portion 6 transitions into the connector mating side 12 of the flange. An annular barb 7 may be formed on an outer wall of the connector portion 6. The cylindrical wall 14 of the connector portion 6 may taper and a thickness of the cylindrical wall 14 may decrease as the cylindrical wall 14 of the connector portion 6 terminates at an outlet port 17.
The flange portion 4 and the connector portion 6 of the sanitary fitting 2 may be formed so that both the central opening 9 of the planar ring 8 of the flange portion 4 and the lumen 18 of the connector portion 6 align along a central axis of the sanitary fitting 2. The planar ring 8 of the flange portion 4 may transition to a parabolic entrance 16 formed with a parabolic lead-in geometry. The parabolic entrance 16 may start from a nose 20 (a circular transition line) on the flat face 10 of the flange portion 4 and may extend to transition into the cylindrical wall 14 of the connector portion 6. As discussed below, the parabolic entrance 16 may improve flow characteristics of materials flowing through the sanitary fitting 2. The planar ring 8 of the flange portion 4, the parabolic entrance 16, and the cylindrical wall 14 of the connector portion 6 together may define the lumen 18 to provide continuous flow pathway allowing flow into or out of the sanitary fitting 2.
As shown in
The components of the sanitary fitting 2 may be integrally formed, for example, by injection molding and overmolding processes. While the sanitary fitting 2 is depicted with a flange portion 4 having a circular external circumference, the external circumference or perimeter of the flange portion 4 may define any shape or configuration useful for connecting the sanitary fitting to a bag B or other structure for holding contents needing transfer via the sanitary fitting 2, to a conduit. While the sanitary fitting 2 is shown as having a connector portion 6 with a barbed end 7 for connecting with a length of tubing, for example, the connector portion 6 may have any exterior configuration useful for mating with structures that facilitate the transport of the contents from the bag B. Moreover, while the sanitary fitting 2 is shown as defining an axially extending central opening 9 and lumen 18 having cylindrical cross sections, in other embodiments the central opening may comprise an oval shape or another shape useful for transferring contents via sanitary fitting 2.
Vortex-Forming Suction-Relief Ribs
With reference to
With reference to
As shown in
The use of a parabolic entrance geometry in sanitary fittings may provide measurable benefits. For example, a streamlined, parabolic may provide a relatively lower head loss coefficient of 0.04 compared to a typical bell-mouthed fillet with a head loss coefficient of 0.10, and further when compared to a slightly rounded entrance with a head loss coefficient of 0.25.
The benefits of providing a leading edge 32 for the suction-relief ribs 30 with a parabolic geometry versus other leading edge geometries may be appreciated in view of the graph illustrated in
The top surface 55 of the ribs 50 may follow a curve from the leading end portion 56 to a trailing edge portion 64. In some implementations, this curve may follow the same parabolic form as the parabolic entrance 16, a different parabolic form, or another curve altogether, for all or a portion of the top surface. The tapering sidewalls 53 of the ribs 50 may substantially converge at a trailing edge 64 of the ribs 50 and may terminate before reaching the cylindrical wall 14 of the connector portion 6. As shown in
In view of the embodiments presented in
Maintaining sterility within a sealed bag may require preventing contaminates from being introduced to the bag. As such material bags often cannot be vented, gasses may not be used to take the place of the draining media, and a vacuum may be pulled. As a result, the bag may collapse on itself as the contents drain and seal over the opening to the port in the sanitary fitting. Suction-relief may prevent the collapsing bag from blocking the flow. When the features of the vortex-forming, suction-relief ribs 30/50 (e.g., as shown in
Moreover, the ribs 30/50 with parabolic leading edges, parabolic and twisted sidewall shapes, rounded edges, contoured form following the parabolic entrance, and flared transitions to the flange portion and parabolic entrance avoid sharp corners and reduce the chance of the bag tearing. This may lead to reduced contamination risk from a collapsing bag tearing upon contacting standard sharp suction-relief ribs, i.e., squared-off ribs.
Fluid stagnation around suction-relief ridges can cause sediment to build up around such ridges. Fluid/particulate stagnation/sedimentation may cause blockage of the opening in a flange portion and impede flow. The parabolic leading edge of the ribs 30/50 may reduce drag and potential fluid/particulate trapping due to the reduction of flow separation and pressure drops from fluid flowing over the top surface 35/55 of the vertically extending sidewall 33/53. In addition, the parabolic-shaped leading edge of the ribs 30/50 may promote increased flow on either side of the ribs 30/50 as compared to a round radius or flat edge at the transition between the flange portion and the port portion defining the flow lumen.
Each of the ribs 30/50 may be formed with proximal tapered portions 40/60 extending along the parabolic entrances 16. The tapered portions 40/60 may be formed in a curve, which may cause flow rotation or a vortex in the contents flowing through the sanitary fitting. Inducing a vortex flow may aid in flow alignment and control of flow stability, which may contribute to optimizing the volumetric flow rate. Flow alignment may facilitate particulates flowing through the central opening 9 along the parabolic entrances 16, while flow stability may ensure laminar flow through the connector 6 to promote an increased volumetric flow rate. Causing a vortex flow by curving the proximal tapered portions 40/60 may additionally reduce the boundary layer to promote a higher volumetric flow rate. An increase in flow rate as well as the streamlined design of the ribs 30/50 may aid in the reduction of particulate build-up on or around the suction-relief ribs 30/50.
The angle of pitch of the proximal tapered portions 40/60 of the suction-relief ribs 30/50 may facilitate the formation of a vortex flow of the contents passing through the sanitary fitting. An angle of pitch between about 9 and about 12 degrees may be most advantageous, but a pitch of between about 9 and 30 degrees may facilitate vortex formation as well while reducing or preventing a turbulent flow that may create too much spin and thereby reduce the flow velocity or volume flow rate.
All directional references (e.g., proximal, distal, upper, lower, upward, downward, left, right, lateral, front, back, top, bottom, above, below, vertical, horizontal, clockwise, and counterclockwise) are only used for identification purposes to aid the reader's understanding of the present invention, and do not create limitations, particularly as to the position, orientation, or use of the invention. Connection references (e.g., attached, coupled, connected, and joined) are to be construed broadly and may include intermediate members between a collection of elements and relative movement between elements unless otherwise indicated. As such, connection references do not necessarily infer that two elements are directly connected and in fixed relation to each other. The exemplary drawings are for purposes of illustration only and the dimensions, positions, order and relative sizes reflected in the drawings attached hereto may vary.
The above specification, examples and data provide a complete description of the structure and use of exemplary embodiments of the invention as defined in the claims. Although various embodiments of the claimed invention have been described above with a certain degree of particularity, or with reference to one or more individual embodiments, those skilled in the art could make numerous alterations to the disclosed embodiments without departing from the spirit or scope of the claimed invention. Other embodiments are therefore contemplated. It is intended that all matter contained in the above description and shown in the accompanying drawings shall be interpreted as illustrative only of particular embodiments and not limiting. Changes in detail or structure may be made without departing from the basic elements of the invention as defined in the following claims.
This application claims the benefit of priority pursuant to 35 U.S.C. §119(e) of U.S. provisional patent application No. 61/450,083 filed 7 Mar. 2011, entitled “Bag Port with Parabolic Lead-In and Vortexing Suction Relief Ribs”, the contents of which are hereby incorporated by reference as if fully set forth herein.
Number | Name | Date | Kind |
---|---|---|---|
1312152 | Barrow | Aug 1919 | A |
3481632 | Suess | Dec 1969 | A |
3642018 | Egolf et al. | Feb 1972 | A |
D252703 | Cupit | Aug 1979 | S |
4581142 | Fladby et al. | Apr 1986 | A |
D287872 | Eriksson | Jan 1987 | S |
D318101 | Rodgers | Jul 1991 | S |
5070972 | Dourson et al. | Dec 1991 | A |
5188868 | Horii et al. | Feb 1993 | A |
5320389 | Dupont, Jr. | Jun 1994 | A |
5464039 | Bergamini | Nov 1995 | A |
5817113 | Gifford, III et al. | Oct 1998 | A |
5837180 | Linder et al. | Nov 1998 | A |
5971438 | Johnson | Oct 1999 | A |
D464409 | Nishio | Oct 2002 | S |
6679529 | Johnson et al. | Jan 2004 | B2 |
6696018 | Buchanan | Feb 2004 | B2 |
6764284 | Oehman, Jr. | Jul 2004 | B2 |
6782333 | Baker et al. | Aug 2004 | B2 |
6893428 | Willemstyn | May 2005 | B2 |
7284731 | Johnson et al. | Oct 2007 | B1 |
7481462 | Arning et al. | Jan 2009 | B2 |
20020148857 | Savage et al. | Oct 2002 | A1 |
20030226857 | Bibbo et al. | Dec 2003 | A1 |
20070044487 | Craig | Mar 2007 | A1 |
20070102450 | Stiers | May 2007 | A1 |
20080105313 | Gloor et al. | May 2008 | A1 |
20090119886 | Werth | May 2009 | A1 |
20090232595 | Willemstyn et al. | Sep 2009 | A1 |
20100133807 | Bilstad et al. | Jun 2010 | A1 |
20120222764 | Hermann et al. | Sep 2012 | A1 |
Number | Date | Country |
---|---|---|
7402178 | Nov 1975 | DE |
69800752 | Apr 2002 | DE |
202009015434 | May 2010 | DE |
0803273 | Oct 1997 | EP |
0841085 | May 1998 | EP |
2003926 | Dec 2008 | EP |
2437301 | Oct 2007 | GB |
2000170235 | Jun 2000 | JP |
WO 2010040779 | Apr 2010 | WO |
Entry |
---|
International Search Report and Written Opinion dated May 11, 2012, PCT/US2012/028142, 12 pages. |
Bioeaze San Tri-Clamp 3/8 BRB, http://www.safcglobal.com/etc/medialib/docs/Sigma/Product—Information—Sheet/1807p.PAR.0001.File.tmp/1807p.pdf, known at least as early as Sep. 28, 2010, 1 page. |
BioProcessing Fittings, Value Plastics, Inc., http://www.valueplastics.com/products/sanitary—fittings.aspx, known at least as early as Sep. 28, 2010, 3 pages. |
Mitos BioSystems, Mitos Technologies, Inc., http://www.mitostech.com/biooptions.html, known at least as early as Sep. 28, 2010, 12 pages. |
Port Plate—Media Bag and Bio-reactor Connector Plates, Eldon James Corp., http://www.bioresearchonline.com/product.mvc/Port-Plate-Media-ag-and-Bio-reactor-Connecto-0001?VNETCOOKIE=NO, known at least as early as Sep. 28, 2010, 2 pages. |
Rubber Fab Sanitary Tri-Clamp Reusable Hose Fittings, Rubber Fab Item # RF04HB08RTCSS, JME Ellsworth, https://www.jmesanitary.com/Rubber-Fab-Sanitary-Tri-Clamp-Reusable-Hose-Fittings-103528.aspx, known at least as early as Sep. 28, 2010, 2 pages. |
Sanitary Fittings, ThermoplasticBioLogic, http://www.thermoplasticbiologic.com/fittings—sanitary.html, known at least as early as Sep. 28, 2010, 3 pages. |
Number | Date | Country | |
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20120228873 A1 | Sep 2012 | US |
Number | Date | Country | |
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61450083 | Mar 2011 | US |