SBIR Phase I: A Portable Electrochemical Based Pathogen Biosensor

Information

  • NSF Award
  • 0319676
Owner
  • Award Id
    0319676
  • Award Effective Date
    7/1/2003 - 21 years ago
  • Award Expiration Date
    3/31/2004 - 20 years ago
  • Award Amount
    $ 100,000.00
  • Award Instrument
    Standard Grant

SBIR Phase I: A Portable Electrochemical Based Pathogen Biosensor

This Small Business Innovation Research (SBIR) Phase I aims to develop an electrochemical DNA biosensor to simultaneously detect and identify multiple nucleic acid determinants of a variety of biological pathogens using a combination of dynamic hybridization, microfluidics, and electrochemical detection. The sensitivity of the detection method is high enough that polymerase chain reaction (PCR) amplification could be eliminated. The detection system would consist of a sampling device, sample lysis and hybridization chamber fluidically connected to an electrochemical cell for detection. With this method, specific target nucleic acid species captured by oligonucleotide probes on magnetic particles are released into neighboring working electrode where the nucleic acid targets are directly detected by electrochemical oxidation. This provides a method of rapid, highly sensitive, and specific DNA detection without the need for complicated sample purification procedures, exogenous labels, labile reagents, or expensive, heavy, power-hungry instrumentation. <br/><br/>The commercial use of this product will be in military applications and homeland defense for prompt detection of potential bioterrorist attacks. Development of such devices for DNA and RNA detection without the need for amplification steps would also find wide application in the detection of pathogens in medical diagnostics, point-of-care clinical testing, environmental monitoring, agriculture, food production, and various industrial settings.

  • Program Officer
    Om P. Sahai
  • Min Amd Letter Date
    6/23/2003 - 21 years ago
  • Max Amd Letter Date
    12/8/2003 - 21 years ago
  • ARRA Amount

Institutions

  • Name
    Lynntech, Inc
  • City
    COLLEGE STATION
  • State
    TX
  • Country
    United States
  • Address
    2501 Earl Rudder Freeway South
  • Postal Code
    778456023
  • Phone Number
    9797642200

Investigators

  • First Name
    Season
  • Last Name
    Wong
  • Email Address
    season.wong@lynntech.com
  • Start Date
    6/23/2003 12:00:00 AM

FOA Information

  • Name
    Industrial Technology
  • Code
    308000