SBIR Phase I: Comprehensive RNAi Technologies: Vector-Based Expression and Chemical Synthesis

Information

• NSF Award
• 0320480

Owner

• Dharmacon, Inc.

• Award Id

  0320480

• Award Effective Date

  7/1/2003 - 22 years ago

• Award Expiration Date

  12/31/2003 - 21 years ago

• Award Amount

  $ 100,000.00

• Award Instrument

  Standard Grant

This Small Business Innovation Research (SBIR) Phase I Project proposes to develop a broad-based technology platform for RNA interference (RNAi) gene silencing in mammalian cells. Sequence-specific RNAi is achieved by introducing homologous, short interfering RNA duplexes (siRNAs) into cells. siRNAs are generated by several methods of which the most popular are (1) chemically synthesized siRNA duplexes, and (2) short hairpin RNAs (shRNA) expressed from vectors. This project will attempt to bridge these silencing platforms. The follow on Phase II project will build on the integrated technologies to develop a genome-wide platform of siRNAs, shRNA vectors and stable cell lines. The combination of these powerful tools will have broad impacts for general biology, medical and pharmaceutical research and development.<br/><br/>The commercial application of this project will be to meet the needs of researchers involved in biological and medical research.

• Program Officer

  Om P. Sahai

• Min Amd Letter Date

  6/16/2003 - 22 years ago

• Max Amd Letter Date

  6/16/2003 - 22 years ago

• ARRA Amount

• Name

  DHARMACON INC

• City

  LAFAYETTE

• State

  CO

• Country

  United States

• Address

  2650 CRESCENT DR

• Postal Code

  800266337

• Phone Number

  3036049499

• First Name

  Anastasia

• Last Name

  Khvorova

• Email Address

  khvorova.a@dharmacon.com

• Start Date

  6/16/2003 12:00:00 AM

• Name

  Health

• Code

  203000

• Name

  Biomaterials-Short & Long Terms

• Code

  510402