SBIR Phase I: Detection and Identification Instrument for Single Molecule Analysis

Information

• NSF Award
• 0319204

Owner

• RADIATION MONITORING DEVICES, INC.

• Award Id

  0319204

• Award Effective Date

  7/1/2003 - 20 years ago

• Award Expiration Date

  6/30/2004 - 19 years ago

• Award Amount

  $ 100,000.00

• Award Instrument

  Standard Grant

This Small Business Innovative Research (SBIR) Phase I project proposes to develop a novel, low cost laboratory instrument for genetic analysis and single molecule studies. The technology is suitable for the detection and identification of DNA and RNA through fluorescent hybridization probes without the need for Polymerase Chain Reaction amplification, or for proteins and small molecules through fluorescence immunoassays. The general scheme is based on single molecule detection (SMD) and utilizes the two-color cross-correlation spectroscopy (TC-FCCS) technique with coincident detection analysis scheme to simultaneously probe ten focal regions of a microfluidic assay. High efficiency single photon detectivity Geiger mode microavalanche photodiode (uAPD) arrays will function as detection elements.<br/><br/>The commercial applications of the instrument will be in research, medical applications, and for drug development. Applications range from the study of conformational dynamics and interactions of macromolecules to biochemical kinetics of single molecules.

• Program Officer

  Om P. Sahai

• Min Amd Letter Date

  6/18/2003 - 20 years ago

• Max Amd Letter Date

  11/19/2003 - 20 years ago

• ARRA Amount

• Name

  Radiation Monitoring Devices Inc

• City

  Watertown

• State

  MA

• Country

  United States

• Address

  44 Hunt Street

• Postal Code

  024724699

• Phone Number

  6176686801

• First Name

  Arieh

• Last Name

  Karger

• Email Address

  AKarger@RMDInc.com

• Start Date

  6/18/2003 12:00:00 AM

• Name

  Industrial Technology

• Code

  308000