This Small Business Innovation Research Phase II project is aimed at developing a novel digital x-ray detector for macromolecular crystallography. This detector is based on a new generation micro-pixelized scintillator optically coupled to a large area digital readout array. The micro-pixelized scintillator will provide a unique combination of very high sensitivity, spatial resolution, and signal to noise ratios resulting in excellent point spread function (PSF), thus improving the quality of the measured Bragg peak data.<br/><br/>When integrated with a large area digital optical detector it will allow a wide dynamic range and substantially enhanced throughput at relatively low costs. In addition to the structural biology application, the proposed detector would find widespread use in instrumentation wherever high-resolution x-ray imaging is used.