SBIR Phase II: Detection and Identification Instrument for Single Molecule Analysis

Information

• NSF Award
• 0450539

Owner

• RADIATION MONITORING DEVICES, INC.

• Award Id

  0450539

• Award Effective Date

  3/1/2005 - 19 years ago

• Award Expiration Date

  2/29/2008 - 16 years ago

• Award Amount

  $ 500,000.00

• Award Instrument

  Standard Grant

This Small Business Innovation Research (SBIR) Phase II project proposes to develop a novel, low cost laboratory instrument for genetic analysis and single molecule studies. The technology is suitable for the detection and identification of DNA and RNA through fluorescent hybridization probes without the need for Polymerase Chain Reaction (PCR) amplification, or for proteins and small molecules through fluorescence immunoassays. The general scheme is based on single molecule detection (SMD) and utilizes the two-color cross-correlation spectroscopy (TC-FCCS) technique with coincident detection analysis scheme to simultaneously probe ten focal regions of a microfluidic assay. High efficiency single photon detectivity Geiger mode microavalanche photodiode (uAPD) arrays will function as detection elements.<br/><br/>The commercial application of this project will be on biological and medical research, and on the drug development process. Examples of potential applications range from the study of conformational dynamics and interactions of macromolecules to biochemical kinetics of single molecules.

• Program Officer

  Gregory T. Baxter

• Min Amd Letter Date

  2/1/2005 - 19 years ago

• Max Amd Letter Date

  2/6/2007 - 17 years ago

• ARRA Amount

• Name

  Radiation Monitoring Devices Inc

• City

  Watertown

• State

  MA

• Country

  United States

• Address

  44 Hunt Street

• Postal Code

  024724699

• Phone Number

  6176686801

• First Name

  Arieh

• Last Name

  Karger

• Email Address

  AKarger@RMDInc.com

• Start Date

  2/1/2005 12:00:00 AM

• End Date

  08/23/2006

• First Name

  Rajan

• Last Name

  Gurjar

• Email Address

  rgurjar@rmdinc.com

• Start Date

  8/23/2006 12:00:00 AM

• Name

  Industrial Technology

• Code

  308000